TRIM44 Gene
protein-coding GIFtS : 48
GCID: GC11 P035684
tripartite motif containing 44 (Previous name: tripartite motif-containing 44 )
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Aliasesfor TRIM44 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Tripartite Motif Containing 44 1 2 HSA2491282 DIPB1 2 3 Tripartite Motif-Containing Protein 442 MC71 2 Protein DIPB3 Tripartite Motif-Containing 441 2
Export aliases for TRIM44 gene to outside databases Previous GC identifers: GC11P036362 GC11P035723 GC11P035648 GC11P035640 GC11P035382
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Summariesfor TRIM44 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for TRIM44 : This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: TRI44_HUMAN, Q96DX7 Function : May play a role in the process of differentiation and maturation of neuronal cells (By similarity). Mayregulate the activity of TRIM17
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Genomic Viewsfor TRIM44 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_009237.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TRIM44 gene promoter: AML1a AP-1 FOXL1 CREB S8 PPAR-gamma1 deltaCREB COMP1 PPAR-gamma2 Other transcription factors Search SABiosciences Chromatin IP Primers for TRIM44 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TRIM44
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11p13 Ensembl cytogenetic band: 11p13 HGNC cytogenetic band: 11p13 TRIM44 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P035684: view genomic region
(about GC identifiers )
Start:
35,684,353 bp from pter
End:
35,830,930 bp from pter
Size:
146,578 bases
Orientation:
plus strand
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Proteinsfor TRIM44 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TRI44_HUMAN, Q96DX7 (See
protein sequence )Recommended Name: Tripartite motif-containing protein 44 Size : 344 amino acids; 38472 Da
Subunit : Interacts (via coiled coil) with TRIM17 (via coiled coil)
Secondary accessions : D3DR14 Q96QY2 Q9UGK0Explore the universe of human proteins at neXtProt for TRIM44: NX_Q96DX7 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96DX7 TRIM44 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_060053.2 ENSEMBL proteins: ENSP00000299413 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005622 intracellular
IEA --
TRIM44 for ontologies About GeneDecksing TRIM44 Antibody Products: Assay Products for TRIM44:
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Protein
Domains / Familiesfor TRIM44 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TRIM44 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q96DX7 ProtoNet protein and cluster: Q96DX7
1 Blocks protein family : IPB000315 B-box zinc finger signature UniProtKB/Swiss-Prot: TRI44_HUMAN, Q96DX7 Similarity : Contains 1 B box-type zinc finger
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Functionfor TRIM44 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: TRI44_HUMAN, Q96DX7 Function : May play a role in the process of differentiation and maturation of neuronal cells (By similarity). Mayregulate the activity of TRIM17
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TRIM44 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TRIM44OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TRIM44 (NM_017583 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM44 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TRIM44
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM44
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
TRIM44 for ontologies About GeneDecksing 3 GenomeRNAi human phenotypes for TRIM44 :
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Pathways & Interactionsfor TRIM44 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM44 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)2 Interacting proteins for TRIM44 (Q96DX7 3 ENSP00000299413 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor TRIM44 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TRIM44 Search CenterWatch for drugs/clinical trials and news about TRIM44 / TRI44
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Transcriptsfor TRIM44 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TRIM44 gene: NM_017583.4 Unigene Cluster for TRIM44:
Tripartite motif containing 44 Hs.192103 [show with all ESTs ] Unigene Representative Sequence: NM_017583 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000299413 (uc001mwi.2 ) ENST00000532066 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TRIM44 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TRIM44OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TRIM44 (NM_017583 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM44 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TRIM44
Additional cDNA sequence: AJ249128.1 AK021823.1 AK074242.1 BC013166.1 BC024031.2
9 DOTS entries : DT.217852 DT.92450140
DT.100791364 DT.456095 DT.100791363 DT.100791365 DT.120760150 DT.95172453 DT.97809143 24/438 AceView cDNA sequences (see all 438 ):
AA983816 BU856237 T09368 AA595025 CD674566 BE044542 AI205670 BQ005412 AA937303 AA461495 T07459 CA449622 AI915290 AI679772 AW772296 F10614 CA309606 AI269408 AA843388 AI206154 AI521898 BU189049 BM683417 AI377546 GeneLoc Exon Structure
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Expression for TRIM44 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TRIM44 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGTTCTGAAT
About this image TRIM44 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Kidney Cap Mesenchyme Cap Mesenchyme Cells Kidney Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See TRIM44 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TRIM44 SOURCE GeneReport for Unigene cluster: Hs.192103 UniProtKB/Swiss-Prot: TRI44_HUMAN, Q96DX7 Tissue specificity : Highly expressed in testis SABiosciences Expression via Pathway-Focused PCR Array including TRIM44 : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TRIM44Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TRIM44 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TRIM44 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TRIM44 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM44
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Orthologsfor TRIM44 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for TRIM44 gene from 2/8 species (see all 8 ) About this table
ENSEMBL Gene Tree for TRIM44 (if available)TreeFam Gene Tree for TRIM44 (if available)
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Paralogsfor TRIM44 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor TRIM44 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TRIM44 (35684353 - 35830930 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TRIM44: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TRIM44
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Disorders
/ Diseasesfor TRIM44 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TRIM44 for disorders About GeneDecksing
OMIM gene information: 612298
OMIM disorders : --1 disease for TRIM44 : About MalaCards neuronitis 1 disease from the University of Copenhagen DISEASES database for TRIM44 :Sarcoma Human Genome Epidemiology (HuGE) Navigator: TRIM44 (1 document)Export disorders for TRIM44 gene to outside databases
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Publicationsfor TRIM44 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TRIM44 gene, integrated from 9 sources (see all 22 ): (articles sorted by number of sources associating them with TRIM44) Utopia : connect your pdf to the dynamic world of online information
TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase. (PubMed id 19358823) 1 , 2 Urano T.... Inoue S. (2009) Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811) 1 , 2 Taylor T.D....Sakaki Y. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094) 1 Emanuele M.J....Elledge S.J. (2011) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Genomewide association study of movement-related adve rse antipsychotic effects. (PubMed id 19875103) 1 Aberg K....van den Oord E.J. (2010) Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461) 1 Bennett E.J....Harper J.W. (2010)
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External Searches for TRIM44 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TRIM44 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TRIM44 gene
(According to HUGE )
About This Section --
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Specialized Databases showing TRIM44 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TRIM44 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TRIM44 gene: Search GeneIP for patents involving TRIM44 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TRIM44 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for TRIM44 OriGene shRNA RFP for TRIM44 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TRIM44 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TRIM44 OriGene Protein Over-expression Lysate for TRIM44 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TRIM44 OriGene 3'-UTR Clone for TRIM44 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TRIM44 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TRIM44 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for TRIM44 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TRIM44 OriGene Custom Protein Services for TRIM44 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIM44 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TRIM44 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TRIM44 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TRIM44 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TRIM44 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TRIM44
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TRIM44 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM44
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TRIM44
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