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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM44 Gene

protein-coding   GIFtS: 48
GCID: GC11P035684

tripartite motif containing 44

(Previous name: tripartite motif-containing 44 )
 Explore 1 disease affiliated with
TRIM44 via our new
 Human Malady Compendium 
Biological research products
for TRIM44
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Tripartite Motif Containing 441 2     HSA2491282
DIPB1 2 3     Tripartite Motif-Containing Protein 442
MC71 2     Protein DIPB3
Tripartite Motif-Containing 441 2     

External Ids:    HGNC: 190161   Entrez Gene: 547652   Ensembl: ENSG000001663267   OMIM: 6122985   UniProtKB: Q96DX73   

Export aliases for TRIM44 gene to outside databases

Previous GC identifers: GC11P036362 GC11P035723 GC11P035648 GC11P035640 GC11P035382


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRIM44:
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains,
namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TRI44_HUMAN, Q96DX7
Function: May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May
regulate the activity of TRIM17




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM44 gene promoter:
         AML1a   AP-1   FOXL1   CREB   S8   PPAR-gamma1   deltaCREB   COMP1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM44 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM44

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM44


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

TRIM44 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM44 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P035684:  view genomic region     (about GC identifiers)

Start:
35,684,353 bp from pter      End:
35,830,930 bp from pter
Size:
146,578 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRI44_HUMAN, Q96DX7 (See protein sequence)
Recommended Name: Tripartite motif-containing protein 44  
Size: 344 amino acids; 38472 Da
Subunit: Interacts (via coiled coil) with TRIM17 (via coiled coil)
Secondary accessions: D3DR14 Q96QY2 Q9UGK0

Explore the universe of human proteins at neXtProt for TRIM44: NX_Q96DX7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96DX7

  • TRIM44 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060053.2  
    ENSEMBL proteins: 
     ENSP00000299413  

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    Uscn Proteins for TRIM44

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--


    TRIM44 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TRIM44 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000315 Znf_B-box

    Graphical View of Domain Structure for InterPro Entry Q96DX7

    ProtoNet protein and cluster: Q96DX7

    1 Blocks protein family: IPB000315 B-box zinc finger signature

    UniProtKB/Swiss-Prot: TRI44_HUMAN, Q96DX7
    Similarity: Contains 1 B box-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TRI44_HUMAN, Q96DX7
    Function: May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May
    regulate the activity of TRIM17

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19358823
    GO:0008270zinc ion binding IEA--


    TRIM44 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for TRIM44:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras  Synthetic lethal with c-Myc af 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM44

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TRIM44 (Q96DX73 ENSP000002994134) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM17Q9Y5773, ENSP000003477944I2D: score=1 STRING: ENSP00000347794
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM44
    Search CenterWatch for drugs/clinical trials and news about TRIM44 / TRI44 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRIM44 gene: 
    NM_017583.4  

    Unigene Cluster for TRIM44:

    Tripartite motif containing 44
    Hs.192103  [show with all ESTs]
    Unigene Representative Sequence: NM_017583
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299413(uc001mwi.2) ENST00000532066

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    hsa-miR-3678-3p hsa-miR-361-5p hsa-miR-520e hsa-miR-520f hsa-miR-631 hsa-miR-106a hsa-miR-93 hsa-miR-155*
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM44

    Additional cDNA sequence: 

    AJ249128.1 AK021823.1 AK074242.1 BC013166.1 BC024031.2 

    9 DOTS entries:

    DT.217852  DT.92450140  DT.100791364  DT.456095  DT.100791363  DT.100791365  DT.120760150  DT.95172453 
    DT.97809143 

    24/438 AceView cDNA sequences (see all 438):

    AA983816 BU856237 T09368 AA595025 CD674566 BE044542 AI205670 BQ005412 
    AA937303 AA461495 T07459 CA449622 AI915290 AI679772 AW772296 F10614 
    CA309606 AI269408 AA843388 AI206154 AI521898 BU189049 BM683417 AI377546 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM44 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTTCTGAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    TRIM44 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyCap MesenchymeCap Mesenchyme CellsKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TRIM44 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM44

    SOURCE GeneReport for Unigene cluster: Hs.192103

    UniProtKB/Swiss-Prot: TRI44_HUMAN, Q96DX7
    Tissue specificity: Highly expressed in testis

        SABiosciences Expression via Pathway-Focused PCR Array including TRIM44: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM44

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM44 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim441 , 5 tripartite motif-containing 441, 5 89.12(n)1
    92.42(a)1
      2 (54.13 cM)5
    809851  NM_020267.21  NP_064663.21 
     1023001195 
    zebrafish
    (Danio rerio)
    Actinopterygii trim441 tripartite motif-containing 44 52.09(n)
    37.65(a)
      793099  NM_001161749.2  NP_001155221.2 


    ENSEMBL Gene Tree for TRIM44 (if available)
    TreeFam Gene Tree for TRIM44 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2365 NCBI SNPs in TRIM44 are shown (see all 2365    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs6216821,2
    H,--35682458(+) cttggG/Caggac 1 -- us2k16Minor allele frequency- C:0.03NS EA WA NA 652
    rs1438785781,2
    --35682558(+) AAAAAA/TAAATA 1 -- us2k10--------
    rs37587391,2
    C,--35682567(-) TTTTTC/TATTTA 1 -- us2k10--------
    rs1920408251,2
    --35682570(+) ATAAAA/TAAAAT 1 -- us2k10--------
    rs1839260391,2
    --35682712(+) GGTATA/GTTAAC 1 -- us2k10--------
    rs1172331251,2
    F,--35682717(+) ATTAAC/TGTTGA 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs2017100421,2
    --35682745(+) TTGAA-/TTTTTT 1 -- us2k10--------
    rs1158920261,2
    F,--35682864(+) AACCTG/CATTTT 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs734389271,2
    C,--35683075(+) GAATCA/GATGTA 1 -- us2k12Minor allele frequency- G:0.13WA 120
    rs1155246321,2
    F,--35683115(+) CTTCTT/GAATAC 1 -- us2k11Minor allele frequency- G:0.07WA 118

    HapMap Linkage Disequilibrium report for TRIM44 (35684353 - 35830930 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TRIM44: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM44
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TRIM44 for disorders           About GeneDecksing

    OMIM gene information: 612298    OMIM disorders: --

    1 disease for TRIM44:    About MalaCards
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for TRIM44:
    Sarcoma
    Human Genome Epidemiology (HuGE) Navigator: TRIM44 (1 document)

    Export disorders for TRIM44 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM44 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with TRIM44)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase. (PubMed id 19358823)1, 2 Urano T.... Inoue S. (2009)
    2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. Genomewide association study of movement-related adve rse antipsychotic effects. (PubMed id 19875103)1 Aberg K....van den Oord E.J. (2010)
    10. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54765 HGNC: 19016 AceView: TRIM44 Ensembl:ENSG00000166326 euGenes: HUgn54765
    ECgene: TRIM44 H-InvDB: TRIM44

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM44 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRIM44 gene:
    Search GeneIP for patents involving TRIM44

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
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    von Willebrand factor
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