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Aliases for TRIM44 Gene

Aliases for TRIM44 Gene

  • Tripartite Motif Containing 44 2 3 5
  • Tripartite Motif-Containing 44 2 3
  • DIPB 3 4
  • Protein DIPB 4
  • HSA249128 3
  • MC7 3

External Ids for TRIM44 Gene

Previous GeneCards Identifiers for TRIM44 Gene

  • GC11P036362
  • GC11P035723
  • GC11P035648
  • GC11P035640
  • GC11P035382

Summaries for TRIM44 Gene

Entrez Gene Summary for TRIM44 Gene

  • This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM44 Gene

TRIM44 (Tripartite Motif Containing 44) is a Protein Coding gene. Diseases associated with TRIM44 include Isolated Aniridia.

UniProtKB/Swiss-Prot for TRIM44 Gene

  • May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM44 Gene

Genomics for TRIM44 Gene

Regulatory Elements for TRIM44 Gene

Enhancers for TRIM44 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM44 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM44 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM44 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM44 Gene

35,662,692 bp from pter
35,818,007 bp from pter
155,316 bases
Plus strand

Genomic View for TRIM44 Gene

Genes around TRIM44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM44 Gene

Proteins for TRIM44 Gene

  • Protein details for TRIM44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 44
    Protein Accession:
    Secondary Accessions:
    • D3DR14
    • Q96QY2
    • Q9UGK0

    Protein attributes for TRIM44 Gene

    344 amino acids
    Molecular mass:
    38472 Da
    Quaternary structure:
    • Interacts (via coiled coil) with TRIM17 (via coiled coil).

neXtProt entry for TRIM44 Gene

Proteomics data for TRIM44 Gene at MOPED

Post-translational modifications for TRIM44 Gene

  • Ubiquitination at Lys 231, Lys 256, Lys 268, and Lys 314
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM44 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM44 Gene

Domains & Families for TRIM44 Gene

Gene Families for TRIM44 Gene

Protein Domains for TRIM44 Gene


Suggested Antigen Peptide Sequences for TRIM44 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B box-type zinc finger.
  • Contains 1 B box-type zinc finger.
genes like me logo Genes that share domains with TRIM44: view

Function for TRIM44 Gene

Molecular function for TRIM44 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17.

Gene Ontology (GO) - Molecular Function for TRIM44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17577209
genes like me logo Genes that share ontologies with TRIM44: view
genes like me logo Genes that share phenotypes with TRIM44: view

Animal Model Products

miRNA for TRIM44 Gene

miRTarBase miRNAs that target TRIM44

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM44 Gene

Localization for TRIM44 Gene

Subcellular locations from

Jensen Localization Image for TRIM44 Gene COMPARTMENTS Subcellular localization image for TRIM44 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 2
extracellular 1
lysosome 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIM44 Gene

Pathways & Interactions for TRIM44 Gene

SuperPathways for TRIM44 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM44 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRIM44 Gene

Drugs & Compounds for TRIM44 Gene

No Compound Related Data Available

Transcripts for TRIM44 Gene

mRNA/cDNA for TRIM44 Gene

Unigene Clusters for TRIM44 Gene

Tripartite motif containing 44:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM44 Gene

No ASD Table

Relevant External Links for TRIM44 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM44 Gene

mRNA expression in normal human tissues for TRIM44 Gene

Protein differential expression in normal tissues from HIPED for TRIM44 Gene

This gene is overexpressed in Stomach (33.8) and Adrenal (27.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM44 Gene

SOURCE GeneReport for Unigene cluster for TRIM44 Gene Hs.192103

mRNA Expression by UniProt/SwissProt for TRIM44 Gene

Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expression patterns with TRIM44: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for TRIM44 Gene

Orthologs for TRIM44 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM44 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIM44 35
  • 89.22 (n)
  • 89.02 (a)
TRIM44 36
  • 90 (a)
(Canis familiaris)
Mammalia TRIM44 35
  • 82.78 (n)
  • 82.98 (a)
TRIM44 36
  • 84 (a)
(Mus musculus)
Mammalia Trim44 35
  • 86.39 (n)
  • 88.76 (a)
Trim44 16
Trim44 36
  • 92 (a)
(Pan troglodytes)
Mammalia TRIM44 35
  • 99.52 (n)
  • 100 (a)
TRIM44 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Trim44 35
  • 81.78 (n)
  • 82.27 (a)
(Monodelphis domestica)
Mammalia TRIM44 36
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia TRIM44 36
  • 51 (a)
(Anolis carolinensis)
Reptilia TRIM44 36
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trim44 35
  • 59.51 (n)
  • 46.58 (a)
(Danio rerio)
Actinopterygii trim44 35
  • 53.7 (n)
  • 40.91 (a)
trim44 36
  • 31 (a)
Species with no ortholog for TRIM44:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM44 Gene

Gene Tree for TRIM44 (if available)
Gene Tree for TRIM44 (if available)

Paralogs for TRIM44 Gene

No data available for Paralogs for TRIM44 Gene

Variants for TRIM44 Gene

Sequence variations from dbSNP and Humsavar for TRIM44 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs531239 -- 35,681,743(+) TTCTG(C/T)TCCAC intron-variant
rs545562 -- 35,669,979(+) accac(A/G)cccgc intron-variant
rs561462 -- 35,682,768(+) TTTTA(C/T)GAAAG intron-variant
rs589100 -- 35,799,853(-) AGTTC(G/T)GGTTC intron-variant
rs591101 -- 35,794,222(-) GAGGT(A/G)AGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM44 Gene

Variant ID Type Subtype PubMed ID
nsv832121 CNV Gain 17160897

Variation tolerance for TRIM44 Gene

Residual Variation Intolerance Score: 23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM44 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM44 Gene

Disorders for TRIM44 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM44 Gene - From: Orphanet

Disorder Aliases PubMed IDs
isolated aniridia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIM44

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRIM44: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM44 Gene

Publications for TRIM44 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Trim44 facilitates the migration and invasion of human lung cancer cells via the NF-I_B signaling pathway. (PMID: 25345539) Luo Q. … Xu L. (Int. J. Clin. Oncol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Novel function of Trim44 promotes an antiviral response by stabilizing VISA. (PMID: 23460740) Yang B. … Sun B. (J. Immunol. 2013) 3

Products for TRIM44 Gene

Sources for TRIM44 Gene