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Aliases for TRIM43B Gene

Aliases for TRIM43B Gene

  • Tripartite Motif Containing 43B 2 3 5
  • Tripartite Motif-Containing 43B 2

External Ids for TRIM43B Gene

Previous GeneCards Identifiers for TRIM43B Gene

  • GC02M095508
  • GC02M096143
  • GC02M090143
  • GC02M095517
  • GC02M095553
  • GC02M095571
  • GC02M095579

Summaries for TRIM43B Gene

Entrez Gene Summary for TRIM43B Gene

  • This gene encodes a member of a family of proteins containing RING-finger, SPRY, and BBC domains. There is no definitive support for transcription of this locus, and the transcript structure is inferred from other family members. [provided by RefSeq, Oct 2009]

GeneCards Summary for TRIM43B Gene

TRIM43B (Tripartite Motif Containing 43B) is a Protein Coding gene. An important paralog of this gene is TRIM43.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM43B Gene

Genomics for TRIM43B Gene

Regulatory Elements for TRIM43B Gene

Enhancers for TRIM43B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F095314 1.1 FANTOM5 Ensembl ENCODE 2.8 +168.1 168091 3.4 CTCF KLF1 ZFP64 ZNF140 ZIC2 ZNF2 RAD21 ZNF101 ZFHX2 ZNF143 KCNIP3 ZNF514 TRIM43B PROM2 PIR58224
GH02F095024 0.3 FANTOM5 1.6 +460.3 460305 0.3 KCNIP3 MAL TRIM43B RN7SL575P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TRIM43B on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM43B Gene

Chromosome:
2
Start:
95,476,967 bp from pter
End:
95,484,731 bp from pter
Size:
7,765 bases
Orientation:
Minus strand

Genomic View for TRIM43B Gene

Genes around TRIM43B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM43B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM43B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM43B Gene

Proteins for TRIM43B Gene

  • Protein details for TRIM43B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NCK2-TR43B_HUMAN
    Recommended name:
    Tripartite motif-containing protein 43B
    Protein Accession:
    A6NCK2

    Protein attributes for TRIM43B Gene

    Size:
    446 amino acids
    Molecular mass:
    52310 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM43B Gene

Post-translational modifications for TRIM43B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM43B Gene

REFSEQ proteins:

No data available for DME Specific Peptides for TRIM43B Gene

Domains & Families for TRIM43B Gene

Gene Families for TRIM43B Gene

Suggested Antigen Peptide Sequences for TRIM43B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NCK2

UniProtKB/Swiss-Prot:

TR43B_HUMAN :
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Domain:
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM43B: view

Function for TRIM43B Gene

Gene Ontology (GO) - Molecular Function for TRIM43B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM43B: view
genes like me logo Genes that share phenotypes with TRIM43B: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM43B Gene

Localization for TRIM43B Gene

Gene Ontology (GO) - Cellular Components for TRIM43B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM43B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TRIM43B Gene

Pathways & Interactions for TRIM43B Gene

SuperPathways for TRIM43B Gene

No Data Available

Interacting Proteins for TRIM43B Gene

Gene Ontology (GO) - Biological Process for TRIM43B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRIM43B Gene

Transcripts for TRIM43B Gene

mRNA/cDNA for TRIM43B Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM43B Gene

No ASD Table

Relevant External Links for TRIM43B Gene

GeneLoc Exon Structure for
TRIM43B
ECgene alternative splicing isoforms for
TRIM43B

Expression for TRIM43B Gene

mRNA expression in normal human tissues for TRIM43B Gene

mRNA differential expression in normal tissues according to GTEx for TRIM43B Gene

This gene is overexpressed in Testis (x19.3), Brain - Cerebellum (x10.7), and Brain - Cerebellar Hemisphere (x7.5).

NURSA nuclear receptor signaling pathways regulating expression of TRIM43B Gene:

TRIM43B

SOURCE GeneReport for Unigene cluster for TRIM43B Gene:

Hs.723811
genes like me logo Genes that share expression patterns with TRIM43B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRIM43B Gene

Orthologs for TRIM43B Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM43B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC739911 34
  • 98.8 (n)
cow
(Bos Taurus)
Mammalia LOC528629 34
  • 69.41 (n)
rat
(Rattus norvegicus)
Mammalia Trim43a 34
  • 64.86 (n)
Species where no ortholog for TRIM43B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM43B Gene

ENSEMBL:
Gene Tree for TRIM43B (if available)
TreeFam:
Gene Tree for TRIM43B (if available)

Paralogs for TRIM43B Gene

Paralogs for TRIM43B Gene

genes like me logo Genes that share paralogs with TRIM43B: view

Variants for TRIM43B Gene

Sequence variations from dbSNP and Humsavar for TRIM43B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10201845 -- 95,485,211(+) AATCA(A/G)TCTGC upstream-variant-2KB
rs112580510 -- 95,486,535(+) TTTCC(C/T)GGAGC upstream-variant-2KB
rs113094321 -- 95,482,092(+) ATAAT(A/G)ATGAC intron-variant
rs11372234 -- 95,484,475(+) GAGCC(-/G)TTTTT intron-variant, upstream-variant-2KB
rs114549087 -- 95,482,305(+) TTACC(C/T)GGTCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TRIM43B Gene

Variant ID Type Subtype PubMed ID
esv2759076 CNV loss 17122850
esv3575267 CNV gain 25503493
esv3583925 CNV loss 25503493
esv3591652 OTHER inversion 21293372
nsv222 OTHER inversion 15895083
nsv7320 OTHER inversion 18451855
nsv834300 CNV gain 17160897
nsv961450 CNV duplication 23825009
nsv998014 CNV gain 25217958

Relevant External Links for TRIM43B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM43B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TRIM43B Gene

Disorders for TRIM43B Gene

Relevant External Links for TRIM43B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM43B

No disorders were found for TRIM43B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM43B Gene

Publications for TRIM43B Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64

Products for TRIM43B Gene

Sources for TRIM43B Gene

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