Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIM43 Gene

Aliases for TRIM43 Gene

  • Tripartite Motif Containing 43 2 3 5
  • Tripartite Motif-Containing Protein 43 3
  • Tripartite Motif-Containing 43 2
  • TRIM43A 3

External Ids for TRIM43 Gene

Previous GeneCards Identifiers for TRIM43 Gene

  • GC02P094711
  • GC02P095725
  • GC02P095742
  • GC02P095683
  • GC02P095621
  • GC02P096257
  • GC02P090252

Summaries for TRIM43 Gene

GeneCards Summary for TRIM43 Gene

TRIM43 (Tripartite Motif Containing 43) is a Protein Coding gene. Diseases associated with TRIM43 include Facioscapulohumeral Muscular Dystrophy 1. An important paralog of this gene is TRIM49C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM43 Gene

Genomics for TRIM43 Gene

Regulatory Elements for TRIM43 Gene

Enhancers for TRIM43 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TRIM43 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TRIM43 gene promoter:

Genomic Location for TRIM43 Gene

Chromosome:
2
Start:
95,592,018 bp from pter
End:
95,599,778 bp from pter
Size:
7,761 bases
Orientation:
Plus strand

Genomic View for TRIM43 Gene

Genes around TRIM43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM43 Gene

Proteins for TRIM43 Gene

  • Protein details for TRIM43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BQ3-TRI43_HUMAN
    Recommended name:
    Tripartite motif-containing protein 43
    Protein Accession:
    Q96BQ3
    Secondary Accessions:
    • Q53TJ7

    Protein attributes for TRIM43 Gene

    Size:
    446 amino acids
    Molecular mass:
    52265 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM43 Gene

Post-translational modifications for TRIM43 Gene

No Post-translational modifications

Other Protein References for TRIM43 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM43 Gene

Domains & Families for TRIM43 Gene

Gene Families for TRIM43 Gene

Suggested Antigen Peptide Sequences for TRIM43 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BQ3

UniProtKB/Swiss-Prot:

TRI43_HUMAN :
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Domain:
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM43: view

Function for TRIM43 Gene

Gene Ontology (GO) - Molecular Function for TRIM43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM43: view
genes like me logo Genes that share phenotypes with TRIM43: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM43 Gene

Localization for TRIM43 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM43 Gene COMPARTMENTS Subcellular localization image for TRIM43 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM43: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM43 Gene

Pathways & Interactions for TRIM43 Gene

SuperPathways for TRIM43 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM43 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRIM43 Gene

Drugs & Compounds for TRIM43 Gene

No Compound Related Data Available

Transcripts for TRIM43 Gene

mRNA/cDNA for TRIM43 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM43 Gene

Tripartite motif containing 43:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM43 Gene

No ASD Table

Relevant External Links for TRIM43 Gene

GeneLoc Exon Structure for
TRIM43
ECgene alternative splicing isoforms for
TRIM43

Expression for TRIM43 Gene

mRNA expression in normal human tissues for TRIM43 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM43 Gene

This gene is overexpressed in Testis (x17.3), Brain - Cerebellar Hemisphere (x7.2), Brain - Cerebellum (x6.2), Brain - Nucleus accumbens (basal ganglia) (x5.0), and Brain - Amygdala (x4.1).

Protein differential expression in normal tissues from HIPED for TRIM43 Gene

This gene is overexpressed in Monocytes (45.2), Fetal Brain (14.4), and Fetal heart (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM43 Gene



Protein tissue co-expression partners for TRIM43 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM43 Gene:

TRIM43

SOURCE GeneReport for Unigene cluster for TRIM43 Gene:

Hs.232026
genes like me logo Genes that share expression patterns with TRIM43: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TRIM43 Gene

Orthologs for TRIM43 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM43 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC528629 34
  • 69.56 (n)
  • 52.05 (a)
TRIM43 35
  • 49 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC739911 34
  • 98.88 (n)
  • 97.76 (a)
TRIM43 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim43a 34
  • 65.01 (n)
  • 47.74 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 36 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Trim43a 35
  • 41 (a)
OneToMany
Trim43b 35
  • 41 (a)
OneToMany
Trim43c 35
  • 42 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 19 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 29 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 19 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii trim109 35
  • 20 (a)
ManyToMany
Species where no ortholog for TRIM43 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM43 Gene

ENSEMBL:
Gene Tree for TRIM43 (if available)
TreeFam:
Gene Tree for TRIM43 (if available)

Paralogs for TRIM43 Gene

genes like me logo Genes that share paralogs with TRIM43: view

Variants for TRIM43 Gene

Sequence variations from dbSNP and Humsavar for TRIM43 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs4299372 -- 95,590,513(+) ACACC(A/C)CTGGC upstream-variant-2KB
rs6713198 -- 95,594,488(+) AAAGA(G/T)ATTAG intron-variant
rs1834137 -- 95,593,335(+) TTAAC(C/T)AGTAT intron-variant, upstream-variant-2KB
rs1834139 -- 95,593,412(+) CATAG(C/T)AGCCT intron-variant, upstream-variant-2KB
rs2463901 -- 95,595,546(-) TGCTA(C/T)CAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM43 Gene

Variant ID Type Subtype PubMed ID
dgv4008n100 CNV gain 25217958
esv3575267 CNV gain 25503493
esv3591652 OTHER inversion 21293372
nsv1008461 CNV gain 25217958
nsv222 OTHER inversion 15895083
nsv516044 CNV gain+loss 19592680
nsv7320 OTHER inversion 18451855
nsv834300 CNV gain 17160897
nsv961830 CNV duplication 23825009
nsv998014 CNV gain 25217958
nsv998587 CNV gain 25217958

Variation tolerance for TRIM43 Gene

Gene Damage Index Score: 0.76; 16.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM43 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM43 Gene

Disorders for TRIM43 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM43 Gene - From: DISEASES

Disorder Aliases PubMed IDs
facioscapulohumeral muscular dystrophy 1
  • facioscapulohumeral muscular dystrophy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIM43

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM43
genes like me logo Genes that share disorders with TRIM43: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM43 Gene

Publications for TRIM43 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 65
  3. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J. … Sanderson C.M. (Mol. Cell Proteomics 2012) 3 65
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 65
  5. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PMID: 19549727) Markson G. … Sanderson C.M. (Genome Res. 2009) 3 65

Products for TRIM43 Gene

Sources for TRIM43 Gene

Content