Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIM43 Gene

Aliases for TRIM43 Gene

  • Tripartite Motif Containing 43 2 3 5
  • Tripartite Motif-Containing 43 2 3
  • TRIM43A 3

External Ids for TRIM43 Gene

Previous GeneCards Identifiers for TRIM43 Gene

  • GC02P094711
  • GC02P095725
  • GC02P095742
  • GC02P095683
  • GC02P095621
  • GC02P096257
  • GC02P090252

Summaries for TRIM43 Gene

GeneCards Summary for TRIM43 Gene

TRIM43 (Tripartite Motif Containing 43) is a Protein Coding gene. Diseases associated with TRIM43 include facioscapulohumeral muscular dystrophy 1. An important paralog of this gene is TRIM64C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM43 Gene

Genomics for TRIM43 Gene

Regulatory Elements for TRIM43 Gene

Transcription factor binding sites by QIAGEN in the TRIM43 gene promoter:

Genomic Location for TRIM43 Gene

95,592,018 bp from pter
95,599,778 bp from pter
7,761 bases
Plus strand

Genomic View for TRIM43 Gene

Genes around TRIM43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM43 Gene

Proteins for TRIM43 Gene

  • Protein details for TRIM43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 43
    Protein Accession:
    Secondary Accessions:
    • Q53TJ7

    Protein attributes for TRIM43 Gene

    446 amino acids
    Molecular mass:
    52265 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM43 Gene

Proteomics data for TRIM43 Gene at MOPED

Post-translational modifications for TRIM43 Gene

No Post-translational modifications

Other Protein References for TRIM43 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM43 Gene

Domains & Families for TRIM43 Gene

Gene Families for TRIM43 Gene

Suggested Antigen Peptide Sequences for TRIM43 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM43: view

Function for TRIM43 Gene

Gene Ontology (GO) - Molecular Function for TRIM43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TRIM43: view
genes like me logo Genes that share phenotypes with TRIM43: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM43 Gene

Localization for TRIM43 Gene

Subcellular locations from

Jensen Localization Image for TRIM43 Gene COMPARTMENTS Subcellular localization image for TRIM43 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIM43 Gene

Pathways & Interactions for TRIM43 Gene

SuperPathways for TRIM43 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM43 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRIM43 Gene

Drugs & Compounds for TRIM43 Gene

No Compound Related Data Available

Transcripts for TRIM43 Gene

mRNA/cDNA for TRIM43 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM43 Gene

Tripartite motif containing 43:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM43 Gene

No ASD Table

Relevant External Links for TRIM43 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM43 Gene

mRNA expression in normal human tissues for TRIM43 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM43 Gene

This gene is overexpressed in Testis (x17.3), Brain - Cerebellar Hemisphere (x7.2), Brain - Cerebellum (x6.2), Brain - Nucleus accumbens (basal ganglia) (x5.0), and Brain - Amygdala (x4.1).

Protein differential expression in normal tissues from HIPED for TRIM43 Gene

This gene is overexpressed in Monocytes (45.2), Fetal Brain (14.4), and Fetal heart (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM43 Gene

SOURCE GeneReport for Unigene cluster for TRIM43 Gene Hs.232026

genes like me logo Genes that share expression patterns with TRIM43: view

Protein tissue co-expression partners for TRIM43 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TRIM43 Gene

Orthologs for TRIM43 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM43 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC528629 35
  • 69.56 (n)
  • 52.05 (a)
TRIM43 36
  • 49 (a)
(Pan troglodytes)
Mammalia LOC739911 35
  • 98.88 (n)
  • 97.76 (a)
TRIM43 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Trim43a 35
  • 65.01 (n)
  • 47.74 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
-- 36
  • 27 (a)
-- 36
  • 27 (a)
-- 36
  • 30 (a)
-- 36
  • 22 (a)
-- 36
  • 29 (a)
-- 36
  • 30 (a)
-- 36
  • 30 (a)
-- 36
  • 30 (a)
-- 36
  • 29 (a)
-- 36
  • 24 (a)
-- 36
  • 32 (a)
-- 36
  • 32 (a)
-- 36
  • 29 (a)
(Mus musculus)
Mammalia Trim43a 36
  • 41 (a)
Trim43b 36
  • 41 (a)
Trim43c 36
  • 42 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 19 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
-- 36
  • 31 (a)
-- 36
  • 19 (a)
-- 36
  • 22 (a)
-- 36
  • 24 (a)
-- 36
  • 26 (a)
-- 36
  • 28 (a)
(Danio rerio)
Actinopterygii trim109 36
  • 20 (a)
Species with no ortholog for TRIM43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM43 Gene

Gene Tree for TRIM43 (if available)
Gene Tree for TRIM43 (if available)

Paralogs for TRIM43 Gene

genes like me logo Genes that share paralogs with TRIM43: view

Variants for TRIM43 Gene

Sequence variations from dbSNP and Humsavar for TRIM43 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1834137 -- 95,593,335(+) TTAAC(C/T)AGTAT intron-variant, upstream-variant-2KB
rs1834139 -- 95,593,412(+) CATAG(C/T)AGCCT intron-variant, upstream-variant-2KB
rs2551233 -- 95,592,571(+) tttca(C/T)tatgt intron-variant, upstream-variant-2KB
rs2551234 -- 95,592,623(+) acctc(C/G)gcctc intron-variant, upstream-variant-2KB
rs2707321 -- 95,595,594(-) CCTCA(C/T)GTTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM43 Gene

Variant ID Type Subtype PubMed ID
nsv7320 OTHER Inversion 18451855
nsv834300 CNV Gain 17160897
nsv874660 CNV Gain 21882294
nsv222 OTHER Inversion 15895083
nsv516044 CNV Gain+Loss 19592680

Variation tolerance for TRIM43 Gene

Gene Damage Index Score: 0.76; 16.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM43 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM43 Gene

Disorders for TRIM43 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM43 Gene - From: DISEASES

Disorder Aliases PubMed IDs
facioscapulohumeral muscular dystrophy 1
  • facioscapulohumeral muscular dystrophy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIM43

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRIM43: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM43 Gene

Publications for TRIM43 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J. … Sanderson C.M. (Mol. Cell Proteomics 2012) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PMID: 19549727) Markson G. … Sanderson C.M. (Genome Res. 2009) 3

Products for TRIM43 Gene

Sources for TRIM43 Gene

Back to Top