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Aliases for TRIM42 Gene

Aliases for TRIM42 Gene

  • Tripartite Motif Containing 42 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 40 2 3
  • Tripartite Motif-Containing Protein 42 3
  • Tripartite Motif-Containing 42 2
  • PPP1R40 3
  • T4A1 3

External Ids for TRIM42 Gene

Previous GeneCards Identifiers for TRIM42 Gene

  • GC03M141225
  • GC03P141678
  • GC03P141717
  • GC03P141879
  • GC03P140396
  • GC03P137770

Summaries for TRIM42 Gene

Entrez Gene Summary for TRIM42 Gene

  • This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM42 Gene

TRIM42 (Tripartite Motif Containing 42) is a Protein Coding gene.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM42 Gene

Genomics for TRIM42 Gene

Regulatory Elements for TRIM42 Gene

Enhancers for TRIM42 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G140628 0.9 Ensembl ENCODE 18.9 -48.4 -48438 3.1 JUN CEBPB USF2 CTBP1 JUND RAD51 GATA2 CEBPA FOS TRIM42 LOC102724068 GC03P140571
GH03G140719 0.5 ENCODE 15.5 +42.0 42020 1.5 SMARCA4 ZSCAN4 MNT NR2F2 TRIM42 CLSTN2-AS1 GC03P140715 ENSG00000261826
GH03G140595 0.7 ENCODE 10.2 -82.6 -82571 0.2 HDAC1 ESRRA TAL1 ZBTB40 FOSL1 TCF12 NCOR1 NFE2 SMARCE1 MTA2 TRIM42 GC03P140571 LOC102724068
GH03G140725 0.6 FANTOM5 10.9 +47.4 47449 0.4 PKNOX1 POLR2A BHLHE40 IKZF1 FOS DPF2 RELA TRIM42 GC03P140715 ENSG00000261826
GH03G140588 0.4 ENCODE 9.7 -89.3 -89262 0.6 TEAD4 EZH2 TRIM42 ENSG00000249290 GC03P140571 LOC102724068
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM42 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM42 Gene

140,678,024 bp from pter
140,701,150 bp from pter
23,127 bases
Plus strand

Genomic View for TRIM42 Gene

Genes around TRIM42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM42 Gene

Proteins for TRIM42 Gene

  • Protein details for TRIM42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 42
    Protein Accession:
    Secondary Accessions:
    • A1L4B4
    • Q8N832
    • Q8NDL3

    Protein attributes for TRIM42 Gene

    723 amino acids
    Molecular mass:
    82745 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05042.1; Type=Erroneous termination; Positions=709; Note=Translated as Trp.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM42 Gene


neXtProt entry for TRIM42 Gene

Post-translational modifications for TRIM42 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM42 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM42 Gene

Domains & Families for TRIM42 Gene

Suggested Antigen Peptide Sequences for TRIM42 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM42: view

Function for TRIM42 Gene

Gene Ontology (GO) - Molecular Function for TRIM42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM42: view
genes like me logo Genes that share phenotypes with TRIM42: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM42 Gene

Localization for TRIM42 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM42 gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 3

Gene Ontology (GO) - Cellular Components for TRIM42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM42: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM42 Gene

Pathways & Interactions for TRIM42 Gene

SuperPathways for TRIM42 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM42 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRIM42 Gene

Transcripts for TRIM42 Gene

mRNA/cDNA for TRIM42 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM42 Gene

Tripartite motif containing 42:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM42 Gene

No ASD Table

Relevant External Links for TRIM42 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM42 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM42 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM42 Gene

This gene is overexpressed in Testis (x51.7).

Protein differential expression in normal tissues from HIPED for TRIM42 Gene

This gene is overexpressed in Cervix (48.8) and Plasma (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM42 Gene

Protein tissue co-expression partners for TRIM42 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM42 Gene:


SOURCE GeneReport for Unigene cluster for TRIM42 Gene:

genes like me logo Genes that share expression patterns with TRIM42: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM42 Gene

Orthologs for TRIM42 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM42 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM42 34 35
  • 99.26 (n)
(Canis familiaris)
Mammalia TRIM42 34 35
  • 89.53 (n)
(Bos Taurus)
Mammalia TRIM42 34 35
  • 88.93 (n)
(Rattus norvegicus)
Mammalia Trim42 34
  • 85.71 (n)
(Mus musculus)
Mammalia Trim42 34 16 35
  • 85.62 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 58 (a)
-- 35
  • 54 (a)
(Monodelphis domestica)
Mammalia TRIM42 35
  • 54 (a)
(Gallus gallus)
Aves TRIM42 34 35
  • 55.9 (n)
(Anolis carolinensis)
Reptilia TRIM42 35
  • 47 (a)
Species where no ortholog for TRIM42 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM42 Gene

Gene Tree for TRIM42 (if available)
Gene Tree for TRIM42 (if available)

Paralogs for TRIM42 Gene

No data available for Paralogs for TRIM42 Gene

Variants for TRIM42 Gene

Sequence variations from dbSNP and Humsavar for TRIM42 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000153426 -- 140,678,929(+) ATGAG(A/G)AAACT intron-variant, upstream-variant-2KB
rs1000432369 -- 140,690,140(+) GTGCT(C/T)AGCAA intron-variant
rs1000615070 -- 140,683,414(+) CACTG(C/G)GTTGC intron-variant
rs1000670243 -- 140,676,717(+) TGGTG(A/G)GAGTT intron-variant, upstream-variant-2KB
rs1001056448 -- 140,697,070(+) TTTTG(C/T)TAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM42 Gene

Variant ID Type Subtype PubMed ID
dgv4911n100 CNV gain 25217958
esv2759181 CNV gain+loss 17122850
esv34489 CNV gain 17911159
esv3597954 CNV gain 21293372
esv3597961 CNV gain 21293372
nsv460869 CNV gain 19166990
nsv527831 CNV gain 19592680
nsv591864 CNV gain 21841781
nsv591865 CNV loss 21841781
nsv818170 CNV gain 17921354
nsv829743 CNV loss 17160897

Variation tolerance for TRIM42 Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.65; 94.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM42 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM42 Gene

Disorders for TRIM42 Gene

Relevant External Links for TRIM42

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRIM42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM42 Gene

Publications for TRIM42 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PMID: 19010793) Baranzini S.E. … Oksenberg J.R. (Hum. Mol. Genet. 2009) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N. … Vidal M. (Cell 2015) 3 64
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3 64

Products for TRIM42 Gene

Sources for TRIM42 Gene

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