TRIM41 Gene
protein-coding GIFtS: 46
GCID: GC05P180649
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tripartite motif containing 41(Previous name: tripartite motif-containing 41 )
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Aliases for TRIM41 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Tripartite Motif Containing 411 2 | | E3 Ubiquitin-Protein Ligase TRIM412 | | RINCK1 2 3 | | RING-Finger Protein That Interacts With C Kinase2 | | RING Finger-Interacting Protein With C Kinase2 3 | | EC 6.3.2.-3 | | MGC11271 | | Tripartite Motif-Containing Protein 413 | | Tripartite Motif-Containing 411 | | |
Export aliases for TRIM41 gene to outside databasesPrevious GC identifers: GC05M181702 GC05P180712 GC05P180759 GC05P180582 GC05P175377 |
Summaries for TRIM41 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for TRIM41: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM family is characterized by a signature motifcomposed of a RING finger, one or more B-box domains, and a coiled-coil region. This encoded protein may play a rolein protein kinase C signaling. Multiple transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Oct 2011) UniProtKB/Swiss-Prot: TRI41_HUMAN, Q8WV44Function: Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C Gene Wiki entry for TRIM41
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Genomic Views for TRIM41 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TRIM41 gene promoter: HEN1 AREB6 FAC1 Tal-1 Sp1 MyoD E47 Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIM41
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM41 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35.3 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35.3TRIM41 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P180649: view genomic region
(about GC identifiers)
Start:
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180,649,499 bp from pter |
End:
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180,662,809 bp from pter |
Size:
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13,311 bases |
Orientation:
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plus strand |
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Proteins for TRIM41 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: TRI41_HUMAN, Q8WV44 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase TRIM41 Size: 630 amino acids; 71670 Da
Subunit: Interacts with PRKCA
Subcellular location: Cytoplasm. Nucleus
1 PDB 3D structure from and Proteopedia for TRIM41:2EGM (3D)
 
Secondary accessions: B3KNJ6 D3DWR9 Q5BKT0 Q7L484 Q96Q10 Q9BSL8Alternative splicing: 4 isoforms: Q8WV44-1 Q8WV44-2 Q8WV44-3 Q8WV44-4 Explore the universe of human proteins at neXtProt for TRIM41: NX_Q8WV44
Post-translational modifications:
Auto-ubiquitinated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WV44 TRIM41 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins (2 alternative transcripts):
NP_291027.3 NP_963921.1 ENSEMBL proteins: ENSP00000426803 ENSP00000336749 ENSP00000320869 ENSP00000424979 ENSP00000426790 Human Recombinant Protein Products for TRIM41:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TRIM41 for ontologies About GeneDecksing
TRIM41 Antibody Products: Assay Products for TRIM41: |
Protein
Domains / Families for TRIM41 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIM41 for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry Q8WV44ProtoNet protein and cluster: Q8WV44 4 Blocks protein families: IPB000315 B-box zinc finger signature IPB001841 Zn-finger IPB003879 Butyrophylin C-terminal DUF signature IPB006574 SPRY-associated domain
UniProtKB/Swiss-Prot: TRI41_HUMAN, Q8WV44Similarity: Belongs to the TRIM/RBCC familySimilarity: Contains 1 B box-type zinc fingerSimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 RING-type zinc finger |
Function for TRIM41 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: TRI41_HUMAN, Q8WV44Function: Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C Enzyme Number (IUBMB): EC 6.3.2.-1
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TRIM41 for ontologies About GeneDecksing
Phenotypes: 2 GenomeRNAi human phenotypes for TRIM41: Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM41 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM41 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TRIM41 (NM_033549) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM41 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM41  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM41 |
|
Pathways & Interactions for TRIM41 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: TRI41_HUMAN, Q8WV44Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM41
STRING Interaction
Network Preview (showing 5 interactants - click image to see 21)
 5/27 Interacting proteins for TRIM41 (Q8WV441, 2, 3 ENSP000003208694) via UniProtKB, MINT, STRING, and/or I2D (see all 27) About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016567 | protein ubiquitination |
IEA | -- |
TRIM41 for ontologies About GeneDecksing
|
Drugs & Compounds for TRIM41 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for TRIM41 Search CenterWatch for drugs/clinical trials and news about TRIM41 / TRI41 
|
Transcripts for TRIM41 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for TRIM41 gene (2 alternative transcripts): NM_033549.4 NM_201627.2 Unigene Clusters for TRIM41: Tripartite motif containing 41 Hs.441488 [show with all ESTs], Hs.700303 [show with all ESTs]Unigene Representative Sequences: AK074052, AK0936249 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000515499 ENST00000508930(uc003mng.1) ENST00000351937(uc003mnd.2 uc003mnf.2) ENST00000315073(uc003mne.2) ENST00000503114 ENST00000515223(uc003mnc.2) ENST00000515834(uc010jlq.1) ENST00000514219 ENST00000510072
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM41 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM41 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TRIM41 (NM_033549) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM41 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM41  |
Additional cDNA sequence: AK093624.1 BC127195.1 10 DOTS entries: DT.95168968 DT.100788355 DT.100788354 DT.95231893 DT.100788352 DT.100788353 DT.120838296 DT.100788350 DT.100718926 DT.85104364 24/177 AceView cDNA sequences (see all 177): AI949564 BU622606 AX775799 AI914383 BI793213 AB100367 AX775801 AX775791 AX775803 BU729895 BQ574680 BC018765 CA397745 BC009762 CA444939 CD366889 AK074052 AL046617 BM676964 AX775797 AL137593 BU070299 BM510770 NM_033549 GeneLoc Exon Structure
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Expression for TRIM41 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRIM41 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TTCTTTGGGA
 About this image See TRIM41 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TRIM41
SOURCE GeneReport for Unigene clusters: Hs.441488 Hs.700303
UniProtKB/Swiss-Prot: TRI41_HUMAN, Q8WV44Tissue specificity: Expressed in multiple tissues with the highest levels in heart and skeletal muscle SABiosciences Expression via Pathway-Focused PCR Array including TRIM41:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM41 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TRIM41 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM41 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM41 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM41 |
Orthologs for TRIM41 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TRIM41 gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for TRIM41 (if available) TreeFam Gene Tree for TRIM41 (if available)  |
Paralogs for TRIM41 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for TRIM41 gene
- TRIM502 TRIM312 TRIM352 TRIM522 TRIM732 TRIM692 TRIM742 TRIM622
- TRIM722
18/36 SIMAP similar genes for TRIM41 using alignment to 5 protein entries: TRI41_HUMAN (see all proteins)
(see all similar genes):FLJ00123 DKFZp666N1710 DKFZp434N1710 TRIM52 TRIM64 TRIM64B ERMAP TRIM35 TRIM2 TRIM17 TRIM51 TRIM64C TRIM39 TRIM31 TRIM49 TRIM49C TRIM60 TRIM21
TRIM41 for paralogs About GeneDecksing
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Genomic Variants for TRIM41 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 5 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for TRIM41 (180649499 - 180662809 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TRIM41: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM41 |
|
Disorders
/ Diseases for TRIM41 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRIM41 for disorders About MalaCards
TRIM41 for disorders About GeneDecksing
OMIM gene information: 610530
OMIM disorders: --
Export disorders for TRIM41 gene to outside databases
|
Publications for TRIM41 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRIM41 gene, integrated from 9 sources (see all 19): (articles sorted by number of sources associating them with TRIM41) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Intracellular localization and domain organization of human TRIM41 proteins. (PubMed id 16022281)1, 2, 3 Tanaka M.... Hanai R. (2005)
- Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. (PubMed id 17893151)1, 2 Chen D.... Newton A.C. (2007)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- M phase-specific association of human topoisomerase IIIbeta with chromosomes. (PubMed id 11549288)1, 2 Kobayashi M. and Hanai R. (2001)
- Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
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External Searches for TRIM41 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TRIM41 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRIM41 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRIM41 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for TRIM41 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TRIM41 gene: Search GeneIP for patents involving TRIM41
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for TRIM41 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
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 | |
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for TRIM41 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM41 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM41 | | OriGene Protein Over-expression Lysate for TRIM41 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for TRIM41 | | OriGene 3'-UTR Clone for TRIM41 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM41 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM41 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | TRIM41 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM41 |
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| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM41 |
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