Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM41 Gene

protein-coding   GIFtS: 49
GCID: GC05P180649

Tripartite Motif Containing 41

(Previous name: tripartite motif-containing 41)
  Search for TRIM41
at
MalaCards
 

Aliases
for TRIM41 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Tripartite Motif Containing 411 2     Tripartite Motif-Containing 411
RING-Finger Protein That Interacts With C Kinase1 2     E3 Ubiquitin-Protein Ligase TRIM412
RINCK2 3     EC 6.3.2.-3
RING Finger-Interacting Protein With C Kinase2 3     Tripartite Motif-Containing Protein 413

External Ids:    HGNC: 190131   Entrez Gene: 909332   Ensembl: ENSG000001460637   OMIM: 6105305   UniProtKB: Q8WV443   

Export aliases for TRIM41 gene to outside databases

Previous GC identifers: GC05M181702 GC05P180712 GC05P180759 GC05P180582 GC05P175377


Summaries
for TRIM41 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TRIM41 Gene:
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM family is characterized by a signature
motif composed of a RING finger, one or more B-box domains, and a coiled-coil region. This encoded protein may
play a role in protein kinase C signaling. Multiple transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for TRIM41 Gene: 
TRIM41 (tripartite motif containing 41) is a protein-coding gene. GO annotations related to this gene include zinc ion binding and ligase activity. An important paralog of this gene is TRIM31.

UniProtKB/Swiss-Prot: TRI41_HUMAN, Q8WV44
Function: Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C

Gene Wiki entry for TRIM41 Gene


Genomic Views
for TRIM41 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM41 gene promoter:
         HEN1   AREB6   FAC1   Tal-1   Sp1   MyoD   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TRIM41 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM41

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM41


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

TRIM41 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM41 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P180649:  view genomic region     (about GC identifiers)

Start:
 180,649,499 bp from pter      End:
 180,662,809 bp from pter
Size:
 13,311 bases      Orientation:
 plus strand

Proteins
for TRIM41 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: TRI41_HUMAN, Q8WV44 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM41  
Size: 630 amino acids; 71670 Da
Subunit: Interacts with PRKCA
Subcellular location: Cytoplasm. Nucleus
1 PDB 3D structure from and Proteopedia for TRIM41:
2EGM (3D)    
Secondary accessions: B3KNJ6 D3DWR9 Q5BKT0 Q7L484 Q96Q10 Q9BSL8
Alternative splicing: 4 isoforms:  Q8WV44-1   Q8WV44-2   Q8WV44-3   Q8WV44-4   

Explore the universe of human proteins at neXtProt for TRIM41: NX_Q8WV44

Explore proteomics data for TRIM41 at MOPED 

Post-translational modifications:

  • UniProtKB: Auto-ubiquitinated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WV44

    • TRIM41 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRIM41 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_291027.3  NP_963921.1  

    ENSEMBL proteins: 
     ENSP00000426803   ENSP00000336749   ENSP00000320869   ENSP00000424979   ENSP00000426790  

    Human Recombinant Protein Products for TRIM41: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TRIM41
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TRIM41
    GenScript Custom Purified and Recombinant Proteins Services for TRIM41
    Novus Biologicals TRIM41 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIM41 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    TRIM41 for ontologies           About GeneDecksing



    TRIM41 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TRIM41
    GenScript Custom Superior Antibodies Services for TRIM41
    Novus Biologicals TRIM41 Antibodies
    Abcam antibodies for TRIM41
    Cloud-Clone Corp. Antibodies for TRIM41 
    ThermoFisher Antibodies for TRIM41
    LSBio Antibodies in human, mouse, rat for TRIM41 

    Assay Products for TRIM41: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRIM41
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRIM41
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRIM41 
    Cloud-Clone Corp. CLIAs for TRIM41

    Protein Domains /
    Families
    for TRIM41 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    5/10 InterPro protein domains (see all 10):
     IPR006574 PRY
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q8WV44

    ProtoNet protein and cluster: Q8WV44

    4 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: TRI41_HUMAN, Q8WV44
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    TRIM41 for domains           About GeneDecksing


    Function
    for TRIM41 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI41_HUMAN, Q8WV44
    Function: Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17893151
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    TRIM41 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRIM41:
     Cell cycle / mitosis defect  Decreased TP53 protein express 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRIM41 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRIM41

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM41 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM41 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM41
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM41 (see all 32):
    hsa-miR-596 hsa-let-7d hsa-miR-766 hsa-miR-449a hsa-miR-4267 hsa-let-7g hsa-let-7a hsa-miR-330-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRIM41
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM41

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TRIM41
    Sirion Biotech Customized adenovirus for overexpression of TRIM41

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TRIM41 (see all 12)
    OriGene ORF clones in mouse, rat for TRIM41
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM41 (NM_033549)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM41
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM41
    Sirion Biotech Customized lentivirus for stable overexpression of TRIM41 
                         Customized lentivirus expression plasmids for stable overexpression of TRIM41 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TRIM41
    Search LifeMap BioReagents cell lines for TRIM41
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM41


    Pathways & Interactions
    for TRIM41 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: TRI41_HUMAN, Q8WV44
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM41

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/28 Interacting proteins for TRIM41 (Q8WV441, 2, 3 ENSP000003208694) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    LINC00921O149782, 3MINT-67444 I2D: score=5 
    ZBTB8AQ96BR92, 3, ENSP000003626094MINT-66365 I2D: score=3 STRING: ENSP00000362609
    MPP3Q133682, 3MINT-64793 I2D: score=4 
    ZNF263O149782, 3, ENSP000002190694MINT-67444 I2D: score=5 STRING: ENSP00000219069
    ZNF473Q8WTR72, 3, ENSP000002706174MINT-68105 I2D: score=5 STRING: ENSP00000270617
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    TRIM41 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRIM41 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM41 (TRI41)

    Search CenterWatch for drugs/clinical trials and news about TRIM41 / TRI41

    Transcripts
    for TRIM41 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRIM41 gene (2 alternative transcripts): 
    NM_033549.4  NM_201627.2  

    Unigene Clusters for TRIM41:

    Tripartite motif containing 41
    Hs.441488  [show with all ESTs], Hs.700303  [show with all ESTs]
    Unigene Representative Sequences: AK074052, AK093624
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000515499 ENST00000508930(uc003mng.1) ENST00000351937(uc003mnd.2 uc003mnf.2)
    ENST00000315073(uc003mne.2) ENST00000503114 ENST00000515223(uc003mnc.2)
    ENST00000515834(uc010jlq.1) ENST00000514219 ENST00000510072
    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM41
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM41 (see all 32):
    hsa-miR-596 hsa-let-7d hsa-miR-766 hsa-miR-449a hsa-miR-4267 hsa-let-7g hsa-let-7a hsa-miR-330-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRIM41
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM41
    Clone
    Products:             		 OriGene clones in human, mouse for TRIM41 (see all 12)
    OriGene ORF clones in mouse, rat for TRIM41
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM41 (NM_033549)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM41
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM41
    Sirion Biotech Customized lentivirus for stable overexpression of TRIM41 
                         Customized lentivirus expression plasmids for stable overexpression of TRIM41 
    Primer
    Products:            		OriGene qSTAR qPCR primer pairs in human, mouse for TRIM41
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TRIM41
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM41
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM41

    Additional mRNA sequence: 

    AK093624.1 BC127195.1 

    10 DOTS entries:

    DT.95168968  DT.100788355  DT.100788354  DT.95231893  DT.100788352  DT.100788353  DT.120838296  DT.100788350 
    DT.100718926  DT.85104364 

    24/177 AceView cDNA sequences (see all 177):

    CA444939 BU070531 AX775801 AX775799 BU616379 AI949564 BU622606 AL137593 
    CD676139 BM703995 AB100367 BM676964 BU070299 CD366889 AK074052 AL046617 
    BC004956 AI479463 BU729895 AX775803 BC071887 BE550632 BM563451 AX775797 

    GeneLoc Exon Structure


    Expression
    for TRIM41 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM41 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTTTGGGA
    TRIM41 Expression
    About this image


    See TRIM41 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM41

    SOURCE GeneReport for Unigene clusters: Hs.441488 Hs.700303

    UniProtKB/Swiss-Prot: TRI41_HUMAN, Q8WV44
    Tissue specificity: Expressed in multiple tissues with the highest levels in heart and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including TRIM41: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:    		OriGene qSTAR qPCR primer pairs in human, mouse for TRIM41
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TRIM41
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM41
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM41
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM41

    Orthologs
    for TRIM41 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM41 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Trim411 , 5 tripartite motif-containing 411, 5 89.05(n)1
    94.26(a)1    		   11 (28.78 cM)5
    2110071  NM_145377.21  NP_663352.21 
     488064045 
    chicken
    (Gallus gallus)    		 Aves TRIM411 tripartite motif containing 41 65.57(n)
    60.4(a)    		   417043  NM_001030672.2  NP_001025843.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 Uncharacterized protein
    		 53(a)
    		 1 → many
    		 2(188794430-188807675)
    zebrafish
    (Danio rerio)    		 Actinopterygii trim471 tripartite motif containing 47 45.92(n)
    32.89(a)    		   393254  NM_200284.1  NP_956578.1 


    ENSEMBL Gene Tree for TRIM41 (if available)
    TreeFam Gene Tree for TRIM41 (if available)

    Paralogs
    for TRIM41 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM41 gene
    TRIM312  TRIM502  TRIM522  TRIM732  TRIM612  TRIM352  TRIM692  TRIM742  
    TRIM622  TRIM722  
    18/34 SIMAP similar genes for TRIM41 using alignment to 5 protein entries:     TRI41_HUMAN (see all proteins) (see all similar genes):
    FLJ00123    DKFZp666N1710    DKFZp434N1710    TRIM52    TRIM64    TRIM64B
    ERMAP    TRIM35    TRIM2    TRIM17    TRIM39    TRIM51
    TRIM64C    TRIM49    TRIM49C    TRIM60    TRIM21    TRIM39R

    TRIM41 for paralogs           About GeneDecksing



    Genomic Variants
    for TRIM41 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/502 SNPs in TRIM41 are shown (see all 502)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs113478481,2
    		C,F--175380986(+) CCCCCT/-TTTTT 3 -- int1 trp32Minor allele frequency- -:0.50NA 4
    rs117414931,2
    		C,F,H--175382894(+) aaaaaC/Aaaaaa 3 -- int1 trp31Minor allele frequency- A:0.50NA 2
    rs1121330061,2
    		C--180655844(+) CAGGAA/GAATTG 3 -- int11Minor allele frequency- G:0.00CSA 1
    rs1408200061,2
    		C--180865493(+) GCGCAC/TGGCCC 3 -- us2k10--------
    rs1870733951,2
    		--180865577(+) CTCTTA/GAAGTC 3 -- us2k10--------
    rs559095711,2
    		C,F--180865927(+) CGCGGT/CGCTGG 3 -- us2k12Minor allele frequency- C:0.09NA 122
    rs1115652551,2
    		C,F--180865973(+) TTCTTT/CCTTTG 3 -- us2k12Minor allele frequency- C:0.04NA 122
    rs1501476801,2
    		--180866034(+) CACACA/GGATCG 3 -- us2k10--------
    rs1904283681,2
    		--180866039(+) GGATCA/GGAGAA 3 -- us2k10--------
    rs1826719651,2
    		--180866053(+) CAGGTG/TAGTCC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRIM41 (180649499 - 180662809 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TRIM41:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv462591CNV Loss19166990
    nsv830567CNV Loss17160897
    nsv517697CNV Loss19592680
    dgv6408n71CNV Loss21882294
    dgv6409n71CNV Loss21882294
    nsv883305CNV Gain21882294
    nsv428133CNV Gain18775914

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM41
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM41

    Disorders / Diseases
    for TRIM41 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRIM41 for disorders           About MalaCards
    OMIM gene information: 610530    OMIM disorders: --


    TRIM41 for disorders           About GeneDecksing


    Export disorders for TRIM41 gene to outside databases

    Publications
    for TRIM41 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM41 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with TRIM41)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Intracellular localization and domain organization of human TRIM41 proteins. (PubMed id 16022281)1, 2, 3 Tanaka M.... Hanai R. (2005)
    2. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. (PubMed id 17893151)1, 2 Chen D.... Newton A.C. (2007)
    3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. M phase-specific association of human topoisomerase IIIbeta with chromosomes. (PubMed id 11549288)1, 2 Kobayashi M. and Hanai R. (2001)
    7. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    8. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    External Searches for TRIM41 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TRIM41 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90933 HGNC: 19013 AceView: TRIM41 Ensembl:ENSG00000146063 euGenes: HUgn90933
    ECgene: TRIM41 H-InvDB: TRIM41

    Other Databases showing TRIM41 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TRIM41 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM41 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TRIM41 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TRIM41 gene:
    Search GeneIP for patents involving TRIM41

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TRIM41 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TRIM41  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TRIM41  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TRIM41  
     OriGene qSTAR qPCR primer pairs in human, mouse for TRIM41   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TRIM41   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRIM41   OriGene Custom Protein Services for TRIM41  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIM41
     QIAGEN SeqTarget long-range PCR primers for resequencing TRIM41
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM41
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM41
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM41
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM41
     GenScript Custom Purified and Recombinant Proteins Services for TRIM41 GenScript cDNA clones with any tag delivered in your preferred vector for TRIM41
     GenScript Custom Assay Services for TRIM41 GenScript Custom Superior Antibodies Services for TRIM41
     GenScript Custom overexpressing Cell Line Services for TRIM41 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TRIM41 promoter
     Search Chromatin IP Primers for TRIM41
     RT2 qPCR Primer Assay in human, mouse / rat TRIM41
     Search GNC Networks for TRIM41
     SABiosciences PCR Arrays including human, mouse, rat TRIM41
     Search Tocris compounds for TRIM41 (TRI41)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TRIM41 antibodies
     TRIM41 lysates
     Antibodies for TRIM41
     See all of Abcam's Antibodies, Kits and Proteins for TRIM41
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TRIM41
     Antibodies for TRIM41
     ELISAs for TRIM41
     CLIAs for TRIM41
     Search LifeMap BioReagents cell lines for TRIM41
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM41
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TRIM41
     SwitchGear Promoter luciferase reporter plasmids for TRIM41
     ThermoFisher Antibodies for TRIM41
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM41
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TRIM41
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRIM41
    Customized:
     lentivirus for stable overexpression of TRIM41
     lentivirus expression plasmids for stable overexpression of TRIM41
     adenovirus for overexpression of TRIM41
     LSBio Antibodies in human, mouse, rat for TRIM41
    		Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      TRIM41 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4