TRIM41 Gene

Aliases
for TRIM41 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC05M181702 GC05P180712 GC05P180759 GC05P180582 GC05P175377

Summaries
for TRIM41 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for TRIM41 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000005.9  NT_023133.14  NC_018916.2  

SwitchGear Promoter luciferase reporter plasmids (see all 2): TRIM41 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM41

TRIM41 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P180649:  view genomic region     (about GC identifiers)

Proteins
for TRIM41 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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1 PDB 3D structure from and Proteopedia for TRIM41:

2EGM (3D)    

Explore the universe of human proteins at neXtProt for TRIM41: NX_Q8WV44

Explore proteomics data for TRIM41 at MOPED

Post-translational modifications: 

TRIM41 Human Recombinant Protein Products:

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	antibodies-online peptides for TRIM41

TRIM41 Antibody Products:

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TRIM41 Assay Products:

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	antibodies-online kits for TRIM41 (4 products)

Domains /
Families
for TRIM41 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q8WV44

Find genes that share domains with TRIM41           About GenesLikeMe

Function
for TRIM41 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Enzyme Number (IUBMB): EC 6.3.2.-¹

     Gene Ontology (GO): 4 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for TRIM41

miRNA Products:		Block miRNA regulation of human, mouse, rat TRIM41 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TRIM41 (see all 32):
		hsa-miR-596 hsa-let-7d hsa-miR-766 hsa-miR-449a hsa-miR-4267 hsa-let-7g hsa-let-7a hsa-miR-330-3p
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TRIM41
		Predesigned siRNA for gene silencing in human, mouse, rat TRIM41

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TRIM41

Clone Products:		OriGene clones in human, mouse for TRIM41 (see all 13) OriGene ORF clones in mouse, rat for TRIM41 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TRIM41 (NM_033549)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM41
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM41

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TRIM41
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM41

Localization
for TRIM41 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	5
cytosol	2

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Gene Ontology (GO): 4 cellular component terms:    About this table

Pathways & Interactions
for TRIM41 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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    Pathway & Disease-focused RT² Profiler PCR Array including TRIM41: 

Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for TRIM41 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for TRIM41 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for TRIM41 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TRIM41 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTCTTTGGGA

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for TRIM41
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TRIM41
		QuantiTect SYBR Green Assays in human, mouse, rat TRIM41
		QuantiFast Probe-based Assays in human, mouse, rat TRIM41

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM41

Orthologs
for TRIM41 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for TRIM41 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for TRIM41 gene

TRIM31²  TRIM50²  TRIM10²  TRIM73²  TRIM69²  TRIM15²  TRIM26²  TRIM74²  

TRIM35²  TRIM52²  TRIM62²  TRIM72²  

Selected SIMAP similar genes for TRIM41 using alignment to 5 protein entries:     TRI41_HUMAN (see all proteins) (see all similar genes):

FLJ00123    DKFZp666N1710    DKFZp434N1710    TRIM52    TRIM64    TRIM64B

ERMAP    TRIM35    TRIM31    TRIM2    TRIM17    TRIM39

TRIM51    TRIM64C    TRIM49    TRIM49C    TRIM60    TRIM21

Find genes that share paralogs with TRIM41           About GenesLikeMe

Genomic Variants
for TRIM41 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TRIM41 (see all 502)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs113478481,2	C,F	--	175380986(+)	CCCCCT/-TTTTT	3	--	int1 trp3		2		NA	4
rs117414931,2	C,F,H	--	175382894(+)	aaaaaC/Aaaaaa	3	--	int1 trp3		1		NA	2
rs1121330061,2	C	--	180655844(+)	CAGGAA/GAATTG	3	--	int1		1		CSA	1
rs1408200061,2	C	--	180865493(+)	GCGCAC/TGGCCC	3	--	us2k1		0	--	--	--	--
rs1870733951,2		--	180865577(+)	CTCTTA/GAAGTC	3	--	us2k1		0	--	--	--	--
rs559095711,2	C,F	--	180865927(+)	CGCGGT/CGCTGG	3	--	us2k1		2		NA	122
rs1115652551,2	C,F	--	180865973(+)	TTCTTT/CCTTTG	3	--	us2k1		2		NA	122
rs1501476801,2		--	180866034(+)	CACACA/GGATCG	3	--	us2k1		0	--	--	--	--
rs1904283681,2		--	180866039(+)	GGATCA/GGAGAA	3	--	us2k1		0	--	--	--	--
rs1826719651,2		--	180866053(+)	CAGGTG/TAGTCC	3	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRIM41 (180649499 - 180662809 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for TRIM41:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv462591	CNV	Loss	19166990
nsv830567	CNV	Loss	17160897
nsv517697	CNV	Loss	19592680
dgv6408n71	CNV	Loss	21882294
dgv6409n71	CNV	Loss	21882294
nsv883305	CNV	Gain	21882294
nsv428133	CNV	Gain	18775914

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TRIM41

DNA2.0 Custom Variant and Variant Library Synthesis for TRIM41

Disorders / Diseases
for TRIM41 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for TRIM41 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Intracellular localization and domain organization of human TRIM41 proteins. (PubMed id 16022281)^{1, 2, 3} Tanaka M.... Hanai R. (Mol. Biol. Rep. 2005)
2. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. (PubMed id 17893151)^{1, 2} Chen D.... Newton A.C. (J. Biol. Chem. 2007)
3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)^{1, 2} Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
6. M phase-specific association of human topoisomerase IIIbeta with chromosomes. (PubMed id 11549288)^{1, 2} Kobayashi M. and Hanai R. (Biochem. Biophys. Res. Commun. 2001)
7. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)¹ Couzens A.L....Gingras A.C. (Sci Signal 2013)
8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)¹ Varjosalo M....Gstaiger M. (Cell Rep 2013)
9. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)¹ Woodsmith J....Sanderson C.M. (amp 2012)
10. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)¹ Taipale M....Lindquist S. (Cell 2012)

External Searches for TRIM41 gene

Genome Databases showing TRIM41 gene

Other Databases showing TRIM41 gene

Specialized Databases showing TRIM41 gene

Products
for TRIM41 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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