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Aliases for TRIM40 Gene

Aliases for TRIM40 Gene

  • Tripartite Motif Containing 40 2 3 5
  • Probable E3 NEDD8-Protein Ligase 3 4
  • RING Finger Protein 35 3 4
  • RNF35 3 4
  • Tripartite Motif-Containing 40 2
  • Ring Finger RNF35 3

External Ids for TRIM40 Gene

Previous GeneCards Identifiers for TRIM40 Gene

  • GC06P030189
  • GC06P029875
  • GC06P030210
  • GC06P030212
  • GC06P030103
  • GC06P029920
  • GC06P030281
  • GC06P030317

Summaries for TRIM40 Gene

Entrez Gene Summary for TRIM40 Gene

  • This gene encodes a member of the tripartite motif (TRIM) protein family. The encoded protein may play a role as a negative regulator against inflammation and carcinogenesis in the gastrointestinal tract. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Feb 2014]

GeneCards Summary for TRIM40 Gene

TRIM40 (Tripartite Motif Containing 40) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding.

UniProtKB/Swiss-Prot for TRIM40 Gene

  • May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM40 Gene

Genomics for TRIM40 Gene

Regulatory Elements for TRIM40 Gene

Enhancers for TRIM40 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM40 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM40 Gene

30,134,510 bp from pter
30,148,773 bp from pter
14,264 bases
Plus strand

Genomic View for TRIM40 Gene

Genes around TRIM40 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM40 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TRIM40 Gene

  • Protein details for TRIM40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 40
    Protein Accession:
    Secondary Accessions:
    • Q5SRJ6
    • Q5SS36
    • Q8TD96

    Protein attributes for TRIM40 Gene

    258 amino acids
    Molecular mass:
    29336 Da
    Quaternary structure:
    • Interacts with NEDD8.

    Alternative splice isoforms for TRIM40 Gene


neXtProt entry for TRIM40 Gene

Proteomics data for TRIM40 Gene at MOPED

Post-translational modifications for TRIM40 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM40 Gene

No data available for DME Specific Peptides for TRIM40 Gene

Domains & Families for TRIM40 Gene

Gene Families for TRIM40 Gene

Suggested Antigen Peptide Sequences for TRIM40 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM40: view

Function for TRIM40 Gene

Molecular function for TRIM40 Gene

UniProtKB/Swiss-Prot Function:
May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity.
genes like me logo Genes that share phenotypes with TRIM40: view

Animal Model Products

miRNA for TRIM40 Gene

miRTarBase miRNAs that target TRIM40

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM40 Gene

Localization for TRIM40 Gene

Subcellular locations from

Jensen Localization Image for TRIM40 Gene COMPARTMENTS Subcellular localization image for TRIM40 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIM40 Gene

Pathways & Interactions for TRIM40 Gene

SuperPathways for TRIM40 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030308 negative regulation of cell growth IEA --
GO:0045116 protein neddylation IDA 21474709
genes like me logo Genes that share ontologies with TRIM40: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM40 Gene

Drugs & Compounds for TRIM40 Gene

No Compound Related Data Available

Transcripts for TRIM40 Gene

mRNA/cDNA for TRIM40 Gene

(24) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM40 Gene

Tripartite motif containing 40:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM40 Gene

No ASD Table

Relevant External Links for TRIM40 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM40 Gene

mRNA expression in normal human tissues for TRIM40 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM40 Gene

This gene is overexpressed in Liver (x18.0), Small Intestine - Terminal Ileum (x13.9), Colon - Transverse (x13.0), and Testis (x4.7).

Protein differential expression in normal tissues from HIPED for TRIM40 Gene

This gene is overexpressed in Heart (60.4) and Platelet (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM40 Gene

SOURCE GeneReport for Unigene cluster for TRIM40 Gene Hs.509439

mRNA Expression by UniProt/SwissProt for TRIM40 Gene

Tissue specificity: Highly expressed in normal gastrointestinal epithelia but that is down-regulated in gastrointestinal carcinomas and chronic inflammatory lesions of the gastrointestinal tract.
genes like me logo Genes that share expression patterns with TRIM40: view

Protein tissue co-expression partners for TRIM40 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TRIM40 Gene

Orthologs for TRIM40 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM40 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIM40 35
  • 80.99 (n)
  • 68.86 (a)
TRIM40 36
  • 51 (a)
(Mus musculus)
Mammalia Trim40 35
  • 77.01 (n)
  • 67.67 (a)
Trim40 16
Trim40 36
  • 58 (a)
(Pan troglodytes)
Mammalia TRIM40 35
  • 99.42 (n)
  • 99.13 (a)
TRIM40 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Trim40 35
  • 74.25 (n)
  • 64.23 (a)
(Monodelphis domestica)
Mammalia TRIM40 36
  • 39 (a)
Species with no ortholog for TRIM40:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM40 Gene

Gene Tree for TRIM40 (if available)
Gene Tree for TRIM40 (if available)

Paralogs for TRIM40 Gene

(1) SIMAP similar genes for TRIM40 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM40: view

No data available for Paralogs for TRIM40 Gene

Variants for TRIM40 Gene

Sequence variations from dbSNP and Humsavar for TRIM40 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs12528473 - 30,146,072(+) AGAAG(A/C)AACTG reference, missense
rs757259 -, - 30,147,765(-) TTTCT(C/T)CAACT downstream-variant-500B, reference, missense
rs4959011 -- 30,146,846(+) TCTGC(A/T)ATACC intron-variant
rs4959012 -- 30,147,068(+) CTCCC(C/G/T)CAGCA intron-variant, reference, synonymous-codon
rs4959044 -- 30,146,889(+) GAGGA(C/T)TGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM40 Gene

Variant ID Type Subtype PubMed ID
esv2731777 CNV Deletion 23290073

Variation tolerance for TRIM40 Gene

Residual Variation Intolerance Score: 83.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.21; 76.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRIM40 Gene

Disorders for TRIM40 Gene

Relevant External Links for TRIM40

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRIM40 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM40 Gene

Publications for TRIM40 Gene

  1. TRIM40 promotes neddylation of IKKgamma and is downregulated in gastrointestinal cancers. (PMID: 21474709) Noguchi K. … Hatakeyama S. (Carcinogenesis 2011) 3 4 67
  2. Genome-wide association study of proneness to anger. (PMID: 24489884) Mick E. … Goldberg R.J. (PLoS ONE 2014) 3
  3. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon K.S. … Liu Q. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. (PMID: 20593013) Cree B.A. … . (PLoS ONE 2010) 3

Products for TRIM40 Gene

Sources for TRIM40 Gene