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TRIM4 Gene

protein-coding   GIFtS: 49
GCID: GC07M099474

Tripartite Motif Containing 4

(Previous name: tripartite motif-containing 4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 41 2     Tripartite Motif Protein TRIM41
Tripartite Motif-Containing 41 2     Tripartite Motif-Containing Protein 42
Tripartite Motif Protein 41 2     GOA5
RNF872 3     TRIM475
RING Finger Protein 872 3     

External Ids:    HGNC: 162751   Entrez Gene: 891222   Ensembl: ENSG000001468337   OMIM: 6110415   UniProtKB: Q9C0373   

Export aliases for TRIM4 gene to outside databases

Previous GC identifers: GC07M098022 GC07M099085 GC07M099099 GC07M099133 GC07M099134 GC07M099325 GC07M094123


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIM4 Gene:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes
to cytoplasmic bodies. Its function has not been identified. Alternatively spliced transcript variants that
encode different isoforms have been described.(provided by RefSeq, Jul 2010)

GeneCards Summary for TRIM4 Gene:
TRIM4 (tripartite motif containing 4) is a protein-coding gene. Diseases associated with TRIM4 include dermatophytosis, and myeloproliferative disorder. An important paralog of this gene is TRIM7.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM4 gene promoter:
         HFH-3   SRF   Max1   Spz1   SRF (504 AA)   GATA-1   FOXI1   CP2   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM4 promoter sequence
   Search Chromatin IP Primers for TRIM4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22-q31.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22-q31.1

TRIM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M099474:  view genomic region     (about GC identifiers)

Start:
99,474,581 bp from pter      End:
99,517,223 bp from pter
Size:
42,643 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 98,848,146-98,877,343     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRIM4_HUMAN, Q9C037 (See protein sequence)
Recommended Name: Tripartite motif-containing protein 4  
Size: 500 amino acids; 57461 Da
Secondary accessions: A4D298 Q75MK1 Q96F06 Q9C036
Alternative splicing: 3 isoforms:  Q9C037-1   Q9C037-2   Q9C037-3   

Explore the universe of human proteins at neXtProt for TRIM4: NX_Q9C037

Explore proteomics data for TRIM4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRIM4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_148977.2  NP_149082.1  

    ENSEMBL proteins: 
     ENSP00000396229   ENSP00000348216   ENSP00000275736   ENSP00000346186  

    TRIM4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for TRIM4
    OriGene Protein Over-expression Lysate for TRIM4
    OriGene MassSpec for TRIM4
    OriGene Custom Protein Services for TRIM4
    GenScript Custom Purified and Recombinant Proteins Services for TRIM4
    Novus Biologicals TRIM4 Protein
    Novus Biologicals TRIM4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIM4

    TRIM4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
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    Novus Biologicals TRIM4 Antibodies
    Abcam antibodies for TRIM4
    Cloud-Clone Corp. Antibodies for TRIM4
    ThermoFisher Antibodies for TRIM4
    LSBio Antibodies in human, mouse, rat for TRIM4

    TRIM4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRIM4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRIM4
    Cloud-Clone Corp. CLIAs for TRIM4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 8):
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt
     IPR000315 Znf_B-box

    Graphical View of Domain Structure for InterPro Entry Q9C037

    ProtoNet protein and cluster: Q9C037

    3 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature


    UniProtKB/Swiss-Prot: TRIM4_HUMAN, Q9C037
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    TRIM4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    TRIM4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRIM4:
     Decreased Salmonella enterica   Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRIM4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM4

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRIM4:
    hsa-mir-16-5p (MIRT051223), hsa-mir-96-5p (MIRT027884), hsa-mir-124-3p (MIRT022481)

    Block miRNA regulation of human, mouse, rat TRIM4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TRIM4
    SwitchGear 3'UTR luciferase reporter plasmidTRIM4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRIM4
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRIM4

    Clone
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    OriGene clones in human, mouse for TRIM4 (see all 11)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIM4 (NM_017583)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRIM4
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRIM4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane4
    nucleus3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    TRIM4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM4: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TRIM4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for TRIM4 (ENSP000003482164) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2ENSP000004172814STRING: ENSP00000417281
    TRIM41ENSP000003208694STRING: ENSP00000320869
    SUMO1ENSP000003760764STRING: ENSP00000376076
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070206protein trimerization IDA17156811

    TRIM4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRIM4 gene (2 alternative transcripts): 
    NM_033017.3  NM_033091.2  

    Unigene Cluster for TRIM4:

    Tripartite motif containing 4
    Hs.50749  [show with all ESTs]
    Unigene Representative Sequence: NM_033017
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447480 ENST00000355947(uc003usd.3) ENST00000349062(uc003use.3 uc011kjc.2)
    ENST00000354241(uc003usf.3) ENST00000496896
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRIM4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TRIM4
    SwitchGear 3'UTR luciferase reporter plasmidTRIM4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRIM4
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM4
    Clone
    Products:
         
    OriGene clones in human, mouse for TRIM4 (see all 11)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIM4 (NM_017583)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRIM4
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM4
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TRIM4
      QuantiTect SYBR Green Assays in human, mouse, rat TRIM4
      QuantiFast Probe-based Assays in human, mouse, rat TRIM4

    Additional mRNA sequence: 

    AF220023.1 AF220024.1 AK092892.1 AK293565.1 BC011763.2 BC025949.1 

    8 DOTS entries:

    DT.210668  DT.100814118  DT.95367251  DT.100701833  DT.121107628  DT.91656001  DT.91728902  DT.100674425 

    Selected AceView cDNA sequences (see all 144):

    BM726767 BC011763 CB154036 AW003996 BM683487 AI004200 CA489456 CR609720 
    AA913795 BE503987 AW614857 BQ632397 BC025949 AW629620 AA370143 BQ186783 
    BI966807 AA722712 N38858 BU741082 AA732360 BU608172 AX747794 BU633314 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TRIM4 Expression
    About this image


    TRIM4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
             HyStem+TGFbeta3+GDF5-induced E15 cells
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced E15 cells
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    TRIM4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.50749
        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM4: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TRIM4
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM4
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TRIM4
    QuantiTect SYBR Green Assays in human, mouse, rat TRIM4
    QuantiFast Probe-based Assays in human, mouse, rat TRIM4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for TRIM4 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia TRIM41 tripartite motif containing 4 85.3(n)
    78.27(a)
      608654  XM_845745.2  XP_850838.1 


    ENSEMBL Gene Tree for TRIM4 (if available)
    TreeFam Gene Tree for TRIM4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM4 gene
    TRIM72  TRIM392  TRIM342  TRIML12  TRIM272  TRIM582  TRIM682  TRIM602  
    TRIM222  TRIM172  TRIM52  TRIM62  TRIM6-TRIM342  TRIM212  TRIM382  TRIM112  
    TRIM39-RPP212  
    7 SIMAP similar genes for TRIM4 using alignment to 2 protein entries:     TRIM4_HUMAN (see all proteins):
    TRIM41    TRIM17    TRIM11    TRIM6    TRIM58    TRIM39
    TRIM21

    TRIM4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM4 (see all 609)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1145725561,2
    F--99487544(+) CAATCC/TAATCT 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1839298961,2
    --99487711(+) GTTTAA/CATCTG 2 -- ds50010--------
    rs1386366631,2
    --99487766(+) TCAACA/GTATGT 2 -- ds50010--------
    rs2011830431,2
    C--99487812(+) ATCCT-/GGGAAG 2 -- ds50010--------
    rs1871369921,2
    --99487837(+) GAAACC/TGTTGA 2 -- ds50010--------
    rs1165263451,2
    F--99487986(+) CCATTA/GTTCGG 2 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1918647051,2
    --99488238(+) AACACA/GTGAAC 2 -- ut310--------
    rs1852173911,2
    --99488270(+) TCTCAC/GGTATA 2 -- ut310--------
    rs1898473701,2
    --99488279(+) TAAGGC/GAGAGC 2 -- ut310--------
    rs2022450141,2
    C--99488303(+) CCCAT-/GGACA 
     CAAAAAA
    GGGAA
    2 -- cds10--------

    HapMap Linkage Disequilibrium report for TRIM4 (99474581 - 99517223 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TRIM4: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TRIM4
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611041    OMIM disorders: --

    8 diseases for TRIM4:    
    About MalaCards
    dermatophytosis    myeloproliferative disorder    tonsillitis    neuroblastoma
    cerebritis    thyroiditis    endotheliitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for TRIM4:
    Dermatophytosis

    TRIM4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRIM4

    Export disorders for TRIM4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM4 gene, integrated from 10 sources (see all 21) (see top 10):
    (articles sorted by number of sources associating them with TRIM4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2, 3 Reymond A.... Ballabio A. (EMBO J. 2001)
    2. Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. (PubMed id 21533175)1, 4 Zhai G....Wallaschofski H. (PLoS Genet. 2011)
    3. Human metabolic individuality in biomedical and pharmaceutical research. (PubMed id 21886157)1, 4 Suhre K....Gieger C. (Nature 2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    7. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    8. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    9. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    11. Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins. (PubMed id 21680743)1 Li X....Sodroski J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 89122 HGNC: 16275 AceView: TRIM4 Ensembl:ENSG00000146833 euGenes: HUgn89122
    ECgene: TRIM4 H-InvDB: TRIM4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TRIM4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM4 gene:
    Search GeneIP for patents involving TRIM4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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