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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRIM4 Gene

protein-coding GIFtS: 45
GCID: GC07M099474

tripartite motif containing 4

(Previous name: tripartite motif-containing 4 )

Explore 2 diseases affiliated with
TRIM4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tripartite Motif Containing 4¹ ²
RNF87¹ ² ³
Tripartite Motif-Containing 4¹ ²
RING Finger Protein 87² ³
Tripartite Motif Protein 4²
Tripartite Motif-Containing Protein 4²

External Ids:	HGNC: 16275¹	Entrez Gene: 89122²	Ensembl: ENSG00000146833⁷	UniProtKB: Q9C037³

Export aliases for TRIM4 gene to outside databases

Previous GC identifers: GC07M098022 GC07M099085 GC07M099099 GC07M099133 GC07M099134 GC07M099325 GC07M094123

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRIM4:

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three

zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to

cytoplasmic bodies. Its function has not been identified. Alternatively spliced transcript variants that encode

different isoforms have been described.(provided by RefSeq, Jul 2010)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRIM4 gene promoter:
HFH-3 SRF Max1 Spz1 SRF (504 AA) GATA-1 FOXI1 CP2 FOXJ2 (long isoform) FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRIM4 promoter sequence

Search SABiosciences Chromatin IP Primers for TRIM4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22-q31.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22-q31.1

TRIM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM4 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M099474: view genomic region (about GC identifiers)

Start:	99,474,581 bp from pter	End:	99,517,223 bp from pter
Size:	42,643 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 98,848,146-98,877,343

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRIM4_HUMAN, Q9C037 (See protein sequence)

Recommended Name: Tripartite motif-containing protein 4

Size: 500 amino acids; 57461 Da

Secondary accessions: A4D298 Q75MK1 Q96F06 Q9C036

Alternative splicing: 3 isoforms: Q9C037-1 Q9C037-2 Q9C037-3

Explore the universe of human proteins at neXtProt for TRIM4: NX_Q9C037

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9C037

TRIM4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_148977.2 NP_149082.1

ENSEMBL proteins:

ENSP00000396229 ENSP00000348216 ENSP00000275736 ENSP00000346186

Human Recombinant Protein Products:

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	OriGene Purified Protein: TRIM4 OriGene Protein Over-expression Lysate: TRIM4 OriGene Custom Protein Services for TRIM4
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	Novus Biologicals TRIM4 Protein Novus Biologicals TRIM4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TRIM4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005886	plasma membrane	IDA	--

TRIM4 for ontologies About GeneDecksing

TRIM4 Antibody Products:

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	Novus Biologicals TRIM4 Antibodies
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	Uscn Antibodies for TRIM4
	ThermoFisher Antibodies for TRIM4

Assay Products for TRIM4:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for TRIM4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TRIM4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TRIM4 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR017907 Znf_RING_CS

IPR001841 Znf_RING

IPR001870 B30.2/SPRY

IPR003877 SPRY_rcpt

IPR000315 Znf_B-box

Graphical View of Domain Structure for InterPro Entry Q9C037

ProtoNet protein and cluster: Q9C037

3 Blocks protein families:

IPB000315 B-box zinc finger signature

IPB001841 Zn-finger

IPB003879 Butyrophylin C-terminal DUF signature

UniProtKB/Swiss-Prot: TRIM4_HUMAN, Q9C037

Similarity: Belongs to the TRIM/RBCC family

Similarity: Contains 1 B box-type zinc finger

Similarity: Contains 1 B30.2/SPRY domain

Similarity: Contains 1 RING-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TRIM4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM4
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TRIM4
		SwitchGear 3'UTR luciferase reporter plasmid: TRIM4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM4 OriGene shRNA RFP: TRIM4 OriGene siRNA: TRIM4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TRIM4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM4 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM4 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TRIM4 (NM_017583)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TRIM4
		Search LifeMap BioReagents cell lines for TRIM4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM4

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--

TRIM4 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for TRIM4:

Decreased Salmonella enterica

Decreased Wnt reporter activit

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TRIM4

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for TRIM4 (ENSP00000348216⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MDM2	ENSP00000417281⁴	STRING: ENSP00000417281
TRIM41	ENSP00000320869⁴	STRING: ENSP00000320869
SUMO1	ENSP00000376076⁴	STRING: ENSP00000376076
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0070206	protein trimerization	IDA	17156811

TRIM4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRIM4
Search CenterWatch for drugs/clinical trials and news about TRIM4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRIM4 gene (2 alternative transcripts):

NM_033017.3 NM_033091.2

Unigene Cluster for TRIM4:

Tripartite motif containing 4

Hs.50749 [show with all ESTs]

Unigene Representative Sequence: NM_033017

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000447480 ENST00000355947(uc003usd.3) ENST00000349062(uc003use.3 uc011kjc.2)

ENST00000354241(uc003usf.3) ENST00000496896

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TRIM4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM4
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TRIM4
		SwitchGear 3'UTR luciferase reporter plasmid: TRIM4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM4 OriGene shRNA RFP: TRIM4 OriGene siRNA: TRIM4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM4 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM4 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TRIM4 (NM_017583)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat TRIM4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM4

Additional cDNA sequence:

AF220023.1 AF220024.1 AK092892.1 AK293565.1 BC011763.2 BC025949.1

8 DOTS entries:

DT.210668 DT.100814118 DT.95367251 DT.100701833 DT.121107628 DT.91656001 DT.91728902 DT.100674425

24/144 AceView cDNA sequences (see all 144):

CR609720 AA722712 AA732360 AW003996 BQ186783 AI004200 AW614857 BU741082

AW629620 CA489456 CB154036 BU608172 BM683487 BC025949 BM726767 BQ632397

AA913795 BI966807 AA370143 BC011763 N38858 BE503987 BF109577 AA382736

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRIM4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

TRIM4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

HyStem+BMP4-induced E15 cells (HyStem+BMP4 inductio...)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TRIM4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIM4

SOURCE GeneReport for Unigene cluster: Hs.50749

SABiosciences Expression via Pathway-Focused PCR Array including TRIM4:

Ubiquitin Ligases in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat TRIM4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TRIM4 gene from 4 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chimpanzee (Pan troglodytes)	Mammalia	TRIM4¹	tripartite motif containing 4	99.51(n) 99.79(a)		463583 XM_003318628.1 XP_003318676.1
dog (Canis familiaris)	Mammalia	TRIM4¹	tripartite motif containing 4	85.3(n) 78.27(a)		608654 XM_845745.1 XP_850838.1
platypus (Ornithorhynchus anatinus)	Mammalia	--	Uncharacterized protein	22(a)	possible ortholog	Contig23756(5884-8575)
zebrafish (Danio rerio)	Actinopterygii	trim47⁶	tripartite motif containing 47	26(a)	possible ortholog	10(26752552-26762609)

Species with no ortholog for TRIM4

ENSEMBL Gene Tree for TRIM4 (if available)
TreeFam Gene Tree for TRIM4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TRIM4 gene

TRIM7² TRIM26² TRIM39² TRIM34² TRIML1² TRIM27² TRIM58² TRIM68²

TRIM10² TRIM15² TRIM60² TRIM22² TRIM17² TRIM5² TRIM6² TRIM6-TRIM34²

TRIM21² TRIM38² TRIM39-RPP21² TRIM11²

8 SIMAP similar genes for TRIM4 using alignment to 2 protein entries: TRIM4_HUMAN (see all proteins):

TRIM41 TRIM17 TRIM6 TRIM58 TRIM11 TRIM21

TRIM39 TRIM75

TRIM4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114572556^1,2		--	99487544(+)	`CAATCC/TAATCT`	2	--	ds500¹		1		WA	118
rs183929896^1,2		--	99487711(+)	`GTTTAA/CATCTG`	2	--	ds500¹		0	--	--	--	--
rs138636663^1,2		--	99487766(+)	`TCAACA/GTATGT`	2	--	ds500¹		0	--	--	--	--
rs201183043^1,2		--	99487812(+)	`ATCCT-/GGGAAG`	2	--	ds500¹		0	--	--	--	--
rs187136992^1,2		--	99487837(+)	`GAAACC/TGTTGA`	2	--	ds500¹		0	--	--	--	--
rs116526345^1,2	F,	--	99487986(+)	`CCATTA/GTTCGG`	2	--	ds500¹		1		WA	118
rs191864705^1,2		--	99488238(+)	`AACACA/GTGAAC`	2	--	ut3¹		0	--	--	--	--
rs185217391^1,2		--	99488270(+)	`TCTCAC/GGTATA`	2	--	ut3¹		0	--	--	--	--
rs189847370^1,2		--	99488279(+)	`TAAGGC/GAGAGC`	2	--	ut3¹		0	--	--	--	--
rs202245014^1,2		--	99488303(+)	`CCCAT-/GGACA CAAAAAAGGGAA`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRIM4 (99474581 - 99517223 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TRIM4: --

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM4

DNA2.0 Custom Variant and Variant Library Synthesis for TRIM4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRIM4 for disorders About GeneDecksing

2 diseases for TRIM4: About MalaCards

dermatophytosis myeloproliferative disorder

1 disease from the University of Copenhagen DISEASES database for TRIM4:

Dermatophytosis

Export disorders for TRIM4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TRIM4 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with TRIM4)

Utopia: connect your pdf to the dynamic
world of online information

The tripartite motif family identifies cell compartments. (PubMed id 11331580)^{1, 2, 3} Reymond A.... Ballabio A. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)¹ Woodsmith J....Sanderson C.M. (2012)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Determinants of the higher order association of the re striction factor TRIM5alpha and other tripartite motif (TRIM) proteins. (PubMed id 21680743)¹ Li X....Sodroski J. (2011)
Eight common genetic variants associated with serum D HEAS levels suggest a key role in ageing mechanisms. (PubMed id 21533175)¹ Zhai G....Wallaschofski H. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 89122	HGNC: 16275	AceView: TRIM4	Ensembl:ENSG00000146833	euGenes: HUgn89122
ECgene: TRIM4	H-InvDB: TRIM4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TRIM4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TRIM4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TRIM4 gene:
Search GeneIP for patents involving TRIM4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	OriGene Antibodies for TRIM4		OriGene shRNA RFP for TRIM4
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM4		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM4
	OriGene Protein Over-expression Lysate for TRIM4		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TRIM4		OriGene 3'-UTR Clone for TRIM4
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM4		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM4
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for TRIM4		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TRIM4		OriGene Custom Protein Services for TRIM4
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIM4
	Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM4
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM4
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM4
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM4

	GenScript Custom Purified and Recombinant Proteins Services for TRIM4		GenScript cDNA clones with any tag delivered in your preferred vector for TRIM4
	GenScript Custom Assay Services for TRIM4		GenScript Custom Superior Antibodies Services for TRIM4
	GenScript Custom overexpressing Cell Line Services for TRIM4		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in TRIM4 promoter
	Search Chromatin IP Primers for TRIM4
	RT² qPCR Primer Assay in human, mouse / rat TRIM4
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TRIM4 antibodies
	TRIM4 proteins
	TRIM4 lysates

	Search for Antibodies for TRIM4 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for TRIM4
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Browse ProSpec Recombinant Proteins

TRIM4 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TRIM4

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM4

	SwitchGear 3'UTR luciferase reporter plasmids for TRIM4
	SwitchGear Promoter luciferase reporter plasmids for TRIM4

ThermoFisher Antibodies for TRIM4

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM4

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TRIM4 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

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Export list of displayed genes

TRIM4 Gene

tripartite motif containing 4

Aliases
for TRIM4 gene

Summaries
for TRIM4 gene

Genomic Views
for TRIM4 gene

Proteins
for TRIM4 gene

Protein Domains /
Families
for TRIM4 gene

Function
for TRIM4 gene

Pathways & Interactions
for TRIM4 gene

Drugs & Compounds
for TRIM4 gene

Transcripts
for TRIM4 gene

Expression
for TRIM4 gene

Orthologs
for TRIM4 gene

Paralogs
for TRIM4 gene

Genomic Variants
for TRIM4 gene

Disorders / Diseases
for TRIM4 gene

Publications
for TRIM4 gene

External Searches for TRIM4 gene

Genome Databases showing TRIM4 gene

Other Databases showing TRIM4 gene

Specialized Databases showing TRIM4 gene

Intellectual Property
for TRIM4 gene

Products
for TRIM4 gene

View Random Gene

Advanced Search

Export list of displayed genes

TRIM4 Gene

tripartite motif containing 4

Aliasesfor TRIM4 gene

Summariesfor TRIM4 gene

Genomic Viewsfor TRIM4 gene

Proteinsfor TRIM4 gene

Protein Domains /Familiesfor TRIM4 gene

Functionfor TRIM4 gene

Pathways & Interactionsfor TRIM4 gene

Drugs & Compoundsfor TRIM4 gene

Transcriptsfor TRIM4 gene

Expression for TRIM4 gene

Orthologsfor TRIM4 gene

Paralogsfor TRIM4 gene

Genomic Variantsfor TRIM4 gene

Disorders / Diseasesfor TRIM4 gene

Publicationsfor TRIM4 gene

External Searches for TRIM4 gene

Genome Databases showing TRIM4 gene

Other Databases showing TRIM4 gene

Specialized Databases showing TRIM4 gene

Intellectual Propertyfor TRIM4 gene

Productsfor TRIM4 gene

View Random Gene

Aliases
for TRIM4 gene

Summaries
for TRIM4 gene

Genomic Views
for TRIM4 gene

Proteins
for TRIM4 gene

Protein Domains /
Families
for TRIM4 gene

Function
for TRIM4 gene

Pathways & Interactions
for TRIM4 gene

Drugs & Compounds
for TRIM4 gene

Transcripts
for TRIM4 gene

Expression
for TRIM4 gene

Orthologs
for TRIM4 gene

Paralogs
for TRIM4 gene

Genomic Variants
for TRIM4 gene

Disorders / Diseases
for TRIM4 gene

Publications
for TRIM4 gene

Intellectual Property
for TRIM4 gene

Products
for TRIM4 gene