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Aliases for TRIM4 Gene

Aliases for TRIM4 Gene

  • Tripartite Motif Containing 4 2 3
  • Tripartite Motif-Containing 4 2 3
  • Tripartite Motif Protein 4 2 3
  • RING Finger Protein 87 3 4
  • RNF87 3 4
  • Tripartite Motif-Containing Protein 4 4
  • E3 Ubiquitin-Protein Ligase TRIM4 3
  • Tripartite Motif Protein TRIM4 2
  • EC 6.3.2.- 4
  • TRIM47 6
  • GOA 6

External Ids for TRIM4 Gene

Previous GeneCards Identifiers for TRIM4 Gene

  • GC07M098022
  • GC07M099085
  • GC07M099099
  • GC07M099133
  • GC07M099134
  • GC07M099325
  • GC07M099474
  • GC07M094123

Summaries for TRIM4 Gene

Entrez Gene Summary for TRIM4 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternatively spliced transcript variants that encode different isoforms have been described.[provided by RefSeq, Jul 2010]

GeneCards Summary for TRIM4 Gene

TRIM4 (Tripartite Motif Containing 4) is a Protein Coding gene. Diseases associated with TRIM4 include dermatophytosis. An important paralog of this gene is TRIM58.

UniProtKB/Swiss-Prot for TRIM4 Gene

  • E3 ubiquitin-protein ligase. Mediates Lys-63-linked polyubiquitination of the innate immune receptor DDX58, this linkage doesnt lead to proteasomal degradation but seems to enhance IFN induction.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM4 Gene

Genomics for TRIM4 Gene

Regulatory Elements for TRIM4 Gene

Genomic Location for TRIM4 Gene

99,876,958 bp from pter
99,919,600 bp from pter
42,643 bases
Minus strand

Genomic View for TRIM4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM4 Gene

Proteins for TRIM4 Gene

  • Protein details for TRIM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase TRIM4
    Protein Accession:
    Secondary Accessions:
    • A4D298
    • Q75MK1
    • Q96F06
    • Q9C036

    Protein attributes for TRIM4 Gene

    500 amino acids
    Molecular mass:
    57461 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIM4 Gene


neXtProt entry for TRIM4 Gene

Proteomics data for TRIM4 Gene at MOPED

Post-translational modifications for TRIM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM4 Gene

No data available for DME Specific Peptides for TRIM4 Gene

Domains for TRIM4 Gene

Gene Families for TRIM4 Gene

  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Suggested Antigen Peptide Sequences for TRIM4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9C037
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM4: view

Function for TRIM4 Gene

Molecular function for TRIM4 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase. Mediates Lys-63-linked polyubiquitination of the innate immune receptor DDX58, this linkage doesnt lead to proteasomal degradation but seems to enhance IFN induction.

Enzyme Numbers (IUBMB) for TRIM4 Gene

Gene Ontology (GO) - Molecular Function for TRIM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM4: view

Phenotypes for TRIM4 Gene

genes like me logo Genes that share phenotypes with TRIM4: view

miRNA for TRIM4 Gene

miRTarBase miRNAs that target TRIM4

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIM4 Gene

Localization for TRIM4 Gene

Subcellular locations from

Jensen Localization Image for TRIM4 Gene COMPARTMENTS Subcellular localization image for TRIM4 gene
Compartment Confidence
cytosol 4
plasma membrane 4
nucleus 3

Gene Ontology (GO) - Cellular Components for TRIM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with TRIM4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM4 Gene

Pathways for TRIM4 Gene

SuperPathways for TRIM4 Gene

No Data Available

UniProtKB/Swiss-Prot Q9C037-TRIM4_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0045087 innate immune response IEA --
GO:0070206 protein trimerization IDA 17156811
genes like me logo Genes that share ontologies with TRIM4: view

No data available for Pathways by source for TRIM4 Gene

Transcripts for TRIM4 Gene

Unigene Clusters for TRIM4 Gene

Tripartite motif containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM4 Gene

No ASD Table

Relevant External Links for TRIM4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM4 Gene

mRNA expression in normal human tissues for TRIM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRIM4 Gene

SOURCE GeneReport for Unigene cluster for TRIM4 Gene Hs.50749

genes like me logo Genes that share expressions with TRIM4: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIM4 Gene

Orthologs for TRIM4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM4 35
  • 99.51 (n)
  • 99.79 (a)
(Canis familiaris)
Mammalia TRIM4 35
  • 85.3 (n)
  • 78.27 (a)
TRIM4 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
-- 36
  • 34 (a)
-- 36
  • 36 (a)
-- 36
  • 32 (a)
-- 36
  • 34 (a)
Species with no ortholog for TRIM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM4 Gene

Gene Tree for TRIM4 (if available)
Gene Tree for TRIM4 (if available)

Paralogs for TRIM4 Gene

Selected SIMAP similar genes for TRIM4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TRIM4: view

Variants for TRIM4 Gene

Sequence variations from dbSNP and Humsavar for TRIM4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs892752 -- 99,899,044(-) cccca(C/T)attct intron-variant
rs1048705 -- 99,891,317(-) GAAAG(A/T)CAAAT utr-variant-3-prime
rs1138665 -- 99,896,239(-) gtcat(A/T)gttag intron-variant
rs1865472 -- 99,913,940(-) tatag(A/T)taagg intron-variant
rs2247761 -- 99,903,288(-) TATTC(C/T)CTTGA synonymous-codon, reference

Relevant External Links for TRIM4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TRIM4 Gene

Disorders for TRIM4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TRIM4 Gene including...

Search for TRIM4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TRIM4 Gene

Relevant External Links for TRIM4

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with TRIM4: view

No data available for UniProtKB/Swiss-Prot for TRIM4 Gene

Publications for TRIM4 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3 4
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Human metabolic individuality in biomedical and pharmaceutical research. (PMID: 21886157) Suhre K. … Gieger C. (Nature 2011) 3 48

Products for TRIM4 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TRIM4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM4
    • Block miRNA regulation of TRIM4 using miScript Target Protectors

    Sources for TRIM4 Gene

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