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Aliases for TRIM39-RPP21 Gene

Aliases for TRIM39-RPP21 Gene

  • TRIM39-RPP21 Readthrough 2 3 5
  • Rpp21 Domain-Containing TRIM Protein 3
  • TRIM39-RPP21 Read-Through Transcript 3
  • TRIM39-RPP21 Protein 3
  • TRIM39R 3

External Ids for TRIM39-RPP21 Gene

Previous GeneCards Identifiers for TRIM39-RPP21 Gene

  • GC06U902092
  • GC06P030296
  • GC06P030423
  • GC06P030337
  • GC06P030445
  • GC06P030460
  • GC06P030529
  • GC06P030746
  • GC06P030889

Summaries for TRIM39-RPP21 Gene

Entrez Gene Summary for TRIM39-RPP21 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring TRIM39 (tripartite motif-containing 39) and RPP21 (ribonuclease P/MRP 21kDa subunit) genes on chromosome 6. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Nov 2010]

GeneCards Summary for TRIM39-RPP21 Gene

TRIM39-RPP21 (TRIM39-RPP21 Readthrough) is a Protein Coding gene. Diseases associated with TRIM39-RPP21 include Behcet Syndrome. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. An important paralog of this gene is TRIM39.

Additional gene information for TRIM39-RPP21 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM39-RPP21 Gene

Genomics for TRIM39-RPP21 Gene

Regulatory Elements for TRIM39-RPP21 Gene

Enhancers for TRIM39-RPP21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H030507 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.1 +180.7 180703 3 HDGF PKNOX1 TBL1XR1 NFRKB ZBTB40 BATF TCF12 ZNF121 ZNF766 ELK1 TRIM39-RPP21 HLA-A ABCF1 PPP1R10 TRIM39 HLA-E TRIM26 PPP1R11 PRR3 FLOT1
GH06H030678 1.9 FANTOM5 ENCODE dbSUPER 9.7 +356.4 356419 13 MLX DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC MEF2D PPP1R10 MDC1 IER3 NRM TRIM39 RPL7P4 DHX16 ABCF1 HLA-E PPP1R18
GH06H030527 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.5 +200.1 200124 3 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ABCF1 TRIM39 IER3 DHX16 PRR3 MICD GNL1 MDC1 HCG18 ZNRD1
GH06H030258 1 ENCODE 11.1 -69.3 -69250 1 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS ATF7 ZNF202 MXD4 TRIM39 MDC1 HCG18 DHX16 PPP1R10 HLA-U ZNRD1 ENSG00000233892 HLA-L ETF1P1
GH06H030792 1.7 FANTOM5 Ensembl ENCODE dbSUPER 3.8 +464.9 464949 2 ELF3 TBL1XR1 ZBTB40 RARA RFX5 ZNF207 ATF7 RUNX3 IKZF2 SMARCA5 IER3 VARS2 FLOT1 LINC00243 DDR1 DDR1-AS1 GTF2H4 HCG20 DPCR1 HLA-E
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM39-RPP21 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM39-RPP21 Gene

Chromosome:
6
Start:
30,328,907 bp from pter
End:
30,346,858 bp from pter
Size:
17,952 bases
Orientation:
Plus strand

Genomic View for TRIM39-RPP21 Gene

Genes around TRIM39-RPP21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM39-RPP21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM39-RPP21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TRIM39-RPP21 Gene

  • Protein details for TRIM39-RPP21 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A096LP39
    Recommended name:
    Ribonuclease P protein subunit p21
    Protein Accession:
    A0A096LP39

    Protein attributes for TRIM39-RPP21 Gene

    Size:
    503 amino acids
    Molecular mass:
    57904 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM39-RPP21 Gene

Post-translational modifications for TRIM39-RPP21 Gene

No Post-translational modifications

Other Protein References for TRIM39-RPP21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM39-RPP21 Gene

Domains & Families for TRIM39-RPP21 Gene

Gene Families for TRIM39-RPP21 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TRIM39-RPP21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRIM39-RPP21: view

No data available for UniProtKB/Swiss-Prot for TRIM39-RPP21 Gene

Function for TRIM39-RPP21 Gene

Phenotypes From GWAS Catalog for TRIM39-RPP21 Gene

Gene Ontology (GO) - Molecular Function for TRIM39-RPP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM39-RPP21: view

Phenotypes for TRIM39-RPP21 Gene

genes like me logo Genes that share phenotypes with TRIM39-RPP21: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for TRIM39-RPP21
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM39-RPP21 Gene

Localization for TRIM39-RPP21 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRIM39-RPP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with TRIM39-RPP21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TRIM39-RPP21 Gene

Pathways & Interactions for TRIM39-RPP21 Gene

genes like me logo Genes that share pathways with TRIM39-RPP21: view

Interacting Proteins for TRIM39-RPP21 Gene

Gene Ontology (GO) - Biological Process for TRIM39-RPP21 Gene

None

No data available for SIGNOR curated interactions for TRIM39-RPP21 Gene

Drugs & Compounds for TRIM39-RPP21 Gene

No Compound Related Data Available

Transcripts for TRIM39-RPP21 Gene

mRNA/cDNA for TRIM39-RPP21 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for TRIM39-RPP21
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM39-RPP21 Gene

No ASD Table

Relevant External Links for TRIM39-RPP21 Gene

GeneLoc Exon Structure for
TRIM39-RPP21
ECgene alternative splicing isoforms for
TRIM39-RPP21

Expression for TRIM39-RPP21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM39-RPP21 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for TRIM39-RPP21 Gene



genes like me logo Genes that share expression patterns with TRIM39-RPP21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM39-RPP21 Gene

Orthologs for TRIM39-RPP21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM39-RPP21 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIM39-RPP21 34
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 54 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Trim75 34
  • 22 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
OneToMany
Species where no ortholog for TRIM39-RPP21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM39-RPP21 Gene

ENSEMBL:
Gene Tree for TRIM39-RPP21 (if available)
TreeFam:
Gene Tree for TRIM39-RPP21 (if available)

Paralogs for TRIM39-RPP21 Gene

genes like me logo Genes that share paralogs with TRIM39-RPP21: view

Variants for TRIM39-RPP21 Gene

Sequence variations from dbSNP and Humsavar for TRIM39-RPP21 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000247515 -- 30,327,440(+) CTCTC(A/G)GGAGA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000849666 -- 30,343,376(+) TTGCT(G/T)GTTTG intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1001032100 -- 30,335,575(+) CCCTC(A/G)GCCTC intron-variant
rs1001134805 -- 30,333,465(+) CCATT(C/G)TCCTG intron-variant
rs1001255204 -- 30,329,056(+) AAGAT(A/G)GATCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIM39-RPP21 Gene

Variant ID Type Subtype PubMed ID
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv5241 CNV insertion 18451855
nsv601264 CNV loss 21841781

Variation tolerance for TRIM39-RPP21 Gene

Gene Damage Index Score: 12.64; 94.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM39-RPP21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM39-RPP21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM39-RPP21 Gene

Disorders for TRIM39-RPP21 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM39-RPP21 Gene - From: DISEASES

Disorder Aliases PubMed IDs
behcet syndrome
  • behcet's disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIM39-RPP21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM39-RPP21
genes like me logo Genes that share disorders with TRIM39-RPP21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM39-RPP21 Gene

Publications for TRIM39-RPP21 Gene

  1. TRIM39R, but not TRIM39B, regulates type I interferon response. (PMID: 23707810) Kurata R … Inoko H (Biochemical and biophysical research communications 2013) 3 60
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 60
  3. cGMP-dependent protein kinase I interacts with TRIM39R, a novel Rpp21 domain-containing TRIM protein. (PMID: 17601797) Roberts JD … Bloch KD (American journal of physiology. Lung cellular and molecular physiology 2007) 3 60

Products for TRIM39-RPP21 Gene

Sources for TRIM39-RPP21 Gene

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