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Aliases for TRIM39 Gene

Aliases for TRIM39 Gene

  • Tripartite Motif Containing 39 2 3
  • RNF23 3 4 6
  • TFP 3 4 6
  • Tripartite Motif-Containing Protein 39 3 4
  • Tripartite Motif-Containing 39 2 3
  • Testis-Abundant Finger Protein 3 4
  • Ring Finger Protein 23 2 3
  • E3 Ubiquitin-Protein Ligase TRIM39 3
  • RING Finger Protein 23 4
  • EC 6.3.2.- 4
  • TRIM39B 3

External Ids for TRIM39 Gene

Previous Symbols for TRIM39 Gene

  • RNF23

Summaries for TRIM39 Gene

Entrez Gene Summary for TRIM39 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6. Alternate splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM39 Gene

TRIM39 (Tripartite Motif Containing 39) is a Protein Coding gene. Diseases associated with TRIM39 include dissociative disorder. GO annotations related to this gene include identical protein binding and ligase activity. An important paralog of this gene is TRIM58.

UniProtKB/Swiss-Prot for TRIM39 Gene

  • E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM39 Gene

Genomics for TRIM39 Gene

Genomic Location for TRIM39 Gene

Start:
30,326,479 bp from pter
End:
30,343,729 bp from pter
Size:
17,251 bases
Orientation:
Plus strand

Genomic View for TRIM39 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for TRIM39 Gene

Proteins for TRIM39 Gene

  • Protein details for TRIM39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCM9-TRI39_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM39
    Protein Accession:
    Q9HCM9
    Secondary Accessions:
    • Q5STG3
    • Q5STG4
    • Q76BL3
    • Q8IYT9
    • Q96IB6

    Protein attributes for TRIM39 Gene

    Size:
    518 amino acids
    Molecular mass:
    59690 Da
    Quaternary structure:
    • Interacts with MOAP1.

    Three dimensional structures from OCA and Proteopedia for TRIM39 Gene

    Alternative splice isoforms for TRIM39 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM39 Gene

Proteomics data for TRIM39 Gene at MOPED

Post-translational modifications for TRIM39 Gene

No data available for DME Specific Peptides for TRIM39 Gene

Domains for TRIM39 Gene

Gene Families for TRIM39 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

UniProtKB/Swiss-Prot:

TRI39_HUMAN
Domain:
  • Contains 1 B30.2/SPRY domain.:
    • Q9HCM9
Family:
  • Belongs to the TRIM/RBCC family.:
    • Q9HCM9
Similarity:
  • Contains 1 B box-type zinc finger.:
    • Q9HCM9
  • Contains 1 RING-type zinc finger.:
    • Q9HCM9
genes like me logo Genes that share domains with TRIM39: view

Function for TRIM39 Gene

Molecular function for TRIM39 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1.

Enzyme Numbers (IUBMB) for TRIM39 Gene

Gene Ontology (GO) - Molecular Function for TRIM39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0042802 identical protein binding IPI 16189514
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM39: view

Phenotypes for TRIM39 Gene

GenomeRNAi human phenotypes for TRIM39:
genes like me logo Genes that share phenotypes with TRIM39: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRIM39 Gene

Localization for TRIM39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM39 Gene

Cytoplasm, cytosol. Mitochondrion. Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM39 Gene COMPARTMENTS Subcellular localization image for TRIM39 gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 3

Gene Ontology (GO) - Cellular Components for TRIM39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion IDA 19100260
GO:0005829 cytosol IDA 19100260
genes like me logo Genes that share ontologies with TRIM39: view

Pathways for TRIM39 Gene

SuperPathways for TRIM39 Gene

No Data Available

UniProtKB/Swiss-Prot Q9HCM9-TRI39_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIM39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0016567 protein ubiquitination IEA --
GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA 19100260
GO:2001235 positive regulation of apoptotic signaling pathway IDA 19100260
genes like me logo Genes that share ontologies with TRIM39: view

No data available for Pathways by source for TRIM39 Gene

Transcripts for TRIM39 Gene

mRNA/cDNA for TRIM39 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM39 Gene

Tripartite motif containing 39:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM39 Gene

No ASD Table

Relevant External Links for TRIM39 Gene

GeneLoc Exon Structure for
TRIM39
ECgene alternative splicing isoforms for
TRIM39

Expression for TRIM39 Gene

mRNA expression in normal human tissues for TRIM39 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TRIM39 Gene

SOURCE GeneReport for Unigene cluster for TRIM39 Gene Hs.413493

mRNA Expression by UniProt/SwissProt for TRIM39 Gene

Q9HCM9-TRI39_HUMAN
Tissue specificity: Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis.
genes like me logo Genes that share expressions with TRIM39: view

Orthologs for TRIM39 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM39 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM39 36
  • 99.86 (n)
  • 100 (a)
TRIM39 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM39 36
  • 94.06 (n)
  • 99.39 (a)
dog
(Canis familiaris)
Mammalia TRIM39 36
  • 94.33 (n)
  • 99.39 (a)
TRIM39 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim39 36
  • 90.44 (n)
  • 97.54 (a)
Trim39 16
Trim39 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Trim39 36
  • 89.48 (n)
  • 97.54 (a)
chicken
(Gallus gallus)
Aves TRIM27.1 37
  • 36 (a)
ManyToMany
TRIM39 36
  • 52.94 (n)
  • 42.07 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 69 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii LOC101883816 36
  • 49.49 (n)
  • 38.24 (a)
Species with no ortholog for TRIM39:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM39 Gene

ENSEMBL:
Gene Tree for TRIM39 (if available)
TreeFam:
Gene Tree for TRIM39 (if available)

Paralogs for TRIM39 Gene

Pseudogenes.org Pseudogenes for TRIM39 Gene

genes like me logo Genes that share paralogs with TRIM39: view

Variants for TRIM39 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIM39 Gene

Variant ID Type Subtype PubMed ID
nsv5241 CNV Insertion 18451855

Relevant External Links for TRIM39 Gene

HapMap Linkage Disequilibrium report
TRIM39

No data available for Sequence variations from dbSNP and Humsavar for TRIM39 Gene

Disorders for TRIM39 Gene

(1) MalaCards Diseases for TRIM39 Gene

Search for TRIM39 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TRIM39 Gene

Relevant External Links for TRIM39

Genetic Association Database (GAD)
TRIM39
Human Genome Epidemiology (HuGE) Navigator
TRIM39
genes like me logo Genes that share disorders with TRIM39: view

No data available for UniProtKB/Swiss-Prot for TRIM39 Gene

Publications for TRIM39 Gene

  1. Molecular cloning of testis-abundant finger protein/ring finger protein 23 (RNF23), a novel RING-B box-coiled coil-B30.2 protein on the class I region of the human MHC. (PMID: 11006080) Orimo A. … Muramatsu M. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23
  2. TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process. (PMID: 19100260) Lee S.S. … Yu V.C. (Exp. Cell Res. 2009) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. (PMID: 22529100) Huang N.J. … Kornbluth S. (J. Cell Biol. 2012) 3 4
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 49

Products for TRIM39 Gene

Sources for TRIM39 Gene

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