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TRIM39 Gene

protein-coding   GIFtS: 52
GCID: GC06P030294

Tripartite Motif Containing 39

(Previous names: ring finger protein 23, tripartite motif-containing 39)
(Previous symbol: RNF23)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 391 2     Testis-Abundant Finger Protein2 3
RNF231 2 3 5     Tripartite Motif-Containing Protein 392 3
RING Finger Protein 231 2 3     TRIM39B2
TFP2 3 5     E3 Ubiquitin-Protein Ligase TRIM392
Tripartite Motif-Containing 391 2     EC 6.3.2.-3

External Ids:    HGNC: 100651   Entrez Gene: 566582   Ensembl: ENSG000002045997   OMIM: 6057005   UniProtKB: Q9HCM93   

Export aliases for TRIM39 gene to outside databases

Previous GC identifers: GC06P030352 GC06P030065 GC06P030401 GC06P030403 GC06P030092


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIM39 Gene:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this
protein has not been identified. This gene lies within the major histocompatibility complex class I region on
chromosome 6. Alternate splicing results in two transcript variants encoding different isoforms. (provided by
RefSeq, Jul 2008)

GeneCards Summary for TRIM39 Gene:
TRIM39 (tripartite motif containing 39) is a protein-coding gene. Diseases associated with TRIM39 include tularemia, and gonorrhea. GO annotations related to this gene include identical protein binding and ligase activity. An important paralog of this gene is TRIM7.

UniProtKB/Swiss-Prot: TRI39_HUMAN, Q9HCM9
Function: E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated
poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  NT_113891.3  NT_167244.2  NT_167245.2  NT_167246.2  NT_167248.2  
NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM39 gene promoter:
         NRF-2   AML1a   Nkx2-2   Nkx2-5   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM39 promoter sequence
   Search Chromatin IP Primers for TRIM39

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM39


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

TRIM39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM39 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P030294:  view genomic region     (about GC identifiers)

Start:
30,294,256 bp from pter      End:
30,311,506 bp from pter
Size:
17,251 bases      Orientation:
plus strand

6 alternative locations:
Chr6+,NT_167245 1,588,269-1,605,160      Chr6+,NT_167246 1,642,689-1,659,580      Chr6+,NT_113891.2 1,806,627-1,823,516     
Chr6+,NT_167249 1,624,596-1,641,484      Chr6+,NT_167248 1,587,515-1,604,407      Chr6+,NT_167244 1,606,250-1,623,141     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TRI39_HUMAN, Q9HCM9 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM39  
Size: 518 amino acids; 59690 Da
Subunit: Interacts with MOAP1
3 PDB 3D structures from and Proteopedia for TRIM39:
2DID (3D)        2DIF (3D)        2ECJ (3D)    
Secondary accessions: Q5STG3 Q5STG4 Q76BL3 Q8IYT9 Q96IB6
Alternative splicing: 2 isoforms:  Q9HCM9-1   Q9HCM9-2   

Explore the universe of human proteins at neXtProt for TRIM39: NX_Q9HCM9

Explore proteomics data for TRIM39 at MOPED

Post-translational modifications: 

  • Autoubiquitinated1
  • Ubiquitination2 at Lys92
  • Modification sites at PhosphoSitePlus

  • See TRIM39 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_067076.2  NP_742013.1  

    ENSEMBL proteins: 
     ENSP00000405928   ENSP00000394768   ENSP00000379800   ENSP00000406019   ENSP00000379797  
     ENSP00000405498   ENSP00000365847   ENSP00000397952   ENSP00000379796   ENSP00000388224  
     ENSP00000365844   ENSP00000439400  

    TRIM39 Human Recombinant Protein Products:

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    Novus Biologicals TRIM39 Proteins
    Novus Biologicals TRIM39 Lysates
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    Cloud-Clone Corp. Proteins for TRIM39

    TRIM39 Antibody Products:

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    TRIM39 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 10):
     IPR006574 PRY
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q9HCM9

    ProtoNet protein and cluster: Q9HCM9

    4 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: TRI39_HUMAN, Q9HCM9
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    TRIM39 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI39_HUMAN, Q9HCM9
    Function: E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated
    poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI16189514
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0042802identical protein binding IPI16189514
         
    TRIM39 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRIM39:
     Increased cell death HMECs cel  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM39
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM39
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM39

    miRNA
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    Block miRNA regulation of human, mouse, rat TRIM39 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM39 (see all 33):
    hsa-miR-194* hsa-miR-1197 hsa-miR-3921 hsa-miR-548m hsa-miR-124 hsa-miR-3150b-3p hsa-miR-506 hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmidTRIM39 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRIM39
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM39

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRIM39

    Clone
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    OriGene clones in human, mouse for TRIM39 (see all 14)
    OriGene ORF clones in mouse, rat for TRIM39
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM39 (NM_172016)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM39
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM39

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TRIM39
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRIM39 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM39


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRI39_HUMAN, Q9HCM9: Cytoplasm, cytosol. Mitochondrion. Note=Found predominantly in the cytosol. Partial shift
    from the cytosol to the mitochondria when colocalized with MOAP1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion5
    nucleus3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular ----
    GO:0005739mitochondrion IDA19100260
    GO:0005829cytosol IDA19100260

    TRIM39 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: TRI39_HUMAN, Q9HCM9
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM39: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TRIM39

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for TRIM39 (Q9HCM91, 2, 3 ENSP000003658444) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM17Q9Y5771, 2, 3, ENSP000003477944EBI-739510,EBI-743894 MINT-66402 I2D: score=5 STRING: ENSP00000347794
    DCUN1D1Q96GG92, 3, ENSP000002927824MINT-66918 I2D: score=5 STRING: ENSP00000292782
    PLCD4Q9BRC72, 3, ENSP000003886314MINT-67359 I2D: score=5 STRING: ENSP00000388631
    UBE2D3P610772, 3, ENSP000003497224MINT-67915 I2D: score=5 STRING: ENSP00000349722
    ENSG00000224994Q9HCM91, 2, ENSP000004119494EBI-739510,EBI-739510 MINT-66024 STRING: ENSP00000411949
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0008150biological_process ND--
    GO:0016567protein ubiquitination IEA--
    GO:2000059negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA19100260
    GO:2001235positive regulation of apoptotic signaling pathway IDA19100260

    TRIM39 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM39 (TRI39)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRIM39 gene (2 alternative transcripts): 
    NM_021253.3  NM_172016.2  

    Unigene Cluster for TRIM39:

    Tripartite motif containing 39
    Hs.413493  [show with all ESTs]
    Unigene Representative Sequence: NM_172016
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000458516 ENST00000440271 ENST00000396551(uc003npz.3) ENST00000428728
    ENST00000396548 ENST00000428404 ENST00000376659(uc003nqb.3 uc003nqc.3)
    ENST00000428555 ENST00000396547 ENST00000420746 ENST00000376656(uc010jrz.3)
    ENST00000540416
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRIM39 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM39 (see all 33):
    hsa-miR-194* hsa-miR-1197 hsa-miR-3921 hsa-miR-548m hsa-miR-124 hsa-miR-3150b-3p hsa-miR-506 hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmidTRIM39 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRIM39
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM39
    Clone
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    OriGene ORF clones in mouse, rat for TRIM39
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM39 (NM_172016)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM39
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM39
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM39
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM39
      QuantiTect SYBR Green Assays in human, mouse, rat TRIM39
      QuantiFast Probe-based Assays in human, mouse, rat TRIM39

    Additional mRNA sequence: 

    AB046381.1 AK292512.1 BC007661.2 BC034985.1 BT007370.1 

    13 DOTS entries:

    DT.211152  DT.86846484  DT.97858723  DT.100814392  DT.100814396  DT.92423789  DT.97858724  DT.315448 
    DT.121346123  DT.75125593  DT.121345655  DT.75102321  DT.100814391 

    7 AceView cDNA sequences:

    NM_172016 NM_021253 BC034985 AX776007 BT007370 BC007661 AB046381 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM39 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAACCAAA
    TRIM39 Expression
    About this image


    TRIM39 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    TRIM39 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM39 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.413493

    UniProtKB/Swiss-Prot: TRI39_HUMAN, Q9HCM9
    Tissue specificity: Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and
    testis

        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM39: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM39
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM39

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM39 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim391 , 5 tripartite motif-containing 391, 5 90.44(n)1
    97.54(a)1
      17 (19.01 cM)5
    792631  NM_024468.21  NP_077788.21 
     362588735 
    chicken
    (Gallus gallus)
    Aves TRIM391 tripartite motif containing 39 52.94(n)
    42.07(a)
      417041  NM_001006196.2  NP_001006196.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    69(a)
    1 → many
    2(192582206-192599704)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018838161 zinc-binding protein A33-like 49.49(n)
    38.24(a)
      101883816  XM_005155428.1  XP_005155485.1 


    ENSEMBL Gene Tree for TRIM39 (if available)
    TreeFam Gene Tree for TRIM39 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM39 gene
    TRIM72  TRIM42  TRIM342  TRIML12  TRIM272  TRIM582  TRIM682  TRIM602  
    TRIM222  TRIM172  TRIM52  TRIM62  TRIM6-TRIM342  TRIM212  TRIM382  TRIM112  
    TRIM39-RPP212  
    Selected SIMAP similar genes for TRIM39 using alignment to 8 protein entries:     TRI39_HUMAN (see all proteins) (see all similar genes):
    TRIM39R    TRIM60    ERMAP    TRIM61    FLJ00123    TRIM41
    RNF112    TRIM5    BT3.3    RNF168    TRIM73    TRIM75
    TRIM17    TRIM26    TRIM22    PCGF3    RNF151    TRIM46

    TRIM39 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for TRIM39
    PGOHUM00000244510 PGOHUM00000246132 PGOHUM00000243134


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for TRIM39    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs283839821,2
    C--30206780(+) CACGC-/G/GC  
     CACACGC
    CACAC
    2 -- us2k1 cds10--------

    HapMap Linkage Disequilibrium report for TRIM39 (30294256 - 30311506 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TRIM39:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5241CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM39
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM39

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605700    OMIM disorders: --

    8 diseases for TRIM39:    
    About MalaCards
    tularemia    gonorrhea    acute monocytic leukemia    monocytic leukemia
    behcet's disease    systemic lupus erythematosus    lupus erythematosus    leukemia

    1 disease from the University of Copenhagen DISEASES database for TRIM39:
    Dissociative disorder

    TRIM39 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRIM39
    Human Genome Epidemiology (HuGE) Navigator: TRIM39 (2 documents)

    Export disorders for TRIM39 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM39 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with TRIM39)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of testis-abundant finger protein/ring finger protein 23 (RNF23), a novel RING-B box-coiled coil-B30.2 protein on the class I region of the human MHC. (PubMed id 11006080)1, 2, 3, 9 Orimo A.... Muramatsu M. (Biochem. Biophys. Res. Commun. 2000)
    2. The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. (PubMed id 22529100)1, 2 Huang N.J.... Kornbluth S. (J. Cell Biol. 2012)
    3. TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process. (PubMed id 19100260)1, 2 Lee S.S.... Yu V.C. (Exp. Cell Res. 2009)
    4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    8. TRIM39R, but not TRIM39B, regulates type I interferon response. (PubMed id 23707810)1 Kurata R....Inoko H. (Biochem. Biophys. Res. Commun. 2013)
    9. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    10. Ubiquitylation of p53 by the APC/C inhibitor Trim39. (PubMed id 23213260)1 Zhang L....Kornbluth S. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56658 HGNC: 10065 AceView: TRIM39 Ensembl:ENSG00000204599 euGenes: HUgn56658
    ECgene: TRIM39 H-InvDB: TRIM39

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRIM39 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM39 gene:
    Search GeneIP for patents involving TRIM39

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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