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Aliases for TRIM39 Gene

Aliases for TRIM39 Gene

  • Tripartite Motif Containing 39 2 3
  • RNF23 3 4 6
  • TFP 3 4 6
  • Tripartite Motif-Containing Protein 39 3 4
  • Tripartite Motif-Containing 39 2 3
  • Testis-Abundant Finger Protein 3 4
  • Ring Finger Protein 23 2 3
  • E3 Ubiquitin-Protein Ligase TRIM39 3
  • RING Finger Protein 23 4
  • EC 6.3.2.- 4
  • TRIM39B 3

External Ids for TRIM39 Gene

Previous HGNC Symbols for TRIM39 Gene

  • RNF23

Previous GeneCards Identifiers for TRIM39 Gene

  • GC06P030352
  • GC06P030065
  • GC06P030401
  • GC06P030403
  • GC06P030294
  • GC06P030092

Summaries for TRIM39 Gene

Entrez Gene Summary for TRIM39 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6. Alternate splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM39 Gene

TRIM39 (Tripartite Motif Containing 39) is a Protein Coding gene. Diseases associated with TRIM39 include dissociative disorder. GO annotations related to this gene include identical protein binding and ligase activity. An important paralog of this gene is TRIM58.

UniProtKB/Swiss-Prot for TRIM39 Gene

  • E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM39 Gene

Genomics for TRIM39 Gene

Regulatory Elements for TRIM39 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIM39 Gene

30,326,479 bp from pter
30,343,729 bp from pter
17,251 bases
Plus strand

Genomic View for TRIM39 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TRIM39 Gene

  • Protein details for TRIM39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase TRIM39
    Protein Accession:
    Secondary Accessions:
    • Q5STG3
    • Q5STG4
    • Q76BL3
    • Q8IYT9
    • Q96IB6

    Protein attributes for TRIM39 Gene

    518 amino acids
    Molecular mass:
    59690 Da
    Quaternary structure:
    • Interacts with MOAP1.

    Three dimensional structures from OCA and Proteopedia for TRIM39 Gene

    Alternative splice isoforms for TRIM39 Gene


neXtProt entry for TRIM39 Gene

Proteomics data for TRIM39 Gene at MOPED

Post-translational modifications for TRIM39 Gene

No data available for DME Specific Peptides for TRIM39 Gene

Domains for TRIM39 Gene

Gene Families for TRIM39 Gene

  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Graphical View of Domain Structure for InterPro Entry



  • Q9HCM9
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM39: view

Function for TRIM39 Gene

Molecular function for TRIM39 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1.

Enzyme Numbers (IUBMB) for TRIM39 Gene

Gene Ontology (GO) - Molecular Function for TRIM39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0042802 identical protein binding IPI 16189514
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM39: view

Phenotypes for TRIM39 Gene

GenomeRNAi human phenotypes for TRIM39:
genes like me logo Genes that share phenotypes with TRIM39: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM39

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRIM39 Gene

Localization for TRIM39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM39 Gene

Cytoplasm, cytosol. Mitochondrion. Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1.

Subcellular locations from

Jensen Localization Image for TRIM39 Gene COMPARTMENTS Subcellular localization image for TRIM39 gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 3

Gene Ontology (GO) - Cellular Components for TRIM39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion IDA 19100260
GO:0005829 cytosol IDA 19100260
genes like me logo Genes that share ontologies with TRIM39: view

Pathways for TRIM39 Gene

SuperPathways for TRIM39 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9HCM9-TRI39_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIM39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0016567 protein ubiquitination IEA --
GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA 19100260
GO:2001235 positive regulation of apoptotic signaling pathway IDA 19100260
genes like me logo Genes that share ontologies with TRIM39: view

No data available for Pathways by source for TRIM39 Gene

Transcripts for TRIM39 Gene

mRNA/cDNA for TRIM39 Gene

(7) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM39 Gene

Tripartite motif containing 39:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM39

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TRIM39

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM39 Gene

No ASD Table

Relevant External Links for TRIM39 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM39 Gene

mRNA expression in normal human tissues for TRIM39 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TRIM39 Gene

SOURCE GeneReport for Unigene cluster for TRIM39 Gene Hs.413493

mRNA Expression by UniProt/SwissProt for TRIM39 Gene

Tissue specificity: Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis.
genes like me logo Genes that share expressions with TRIM39: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TRIM39 Gene

Orthologs for TRIM39 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM39 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM39 35
  • 99.86 (n)
  • 100 (a)
TRIM39 36
  • 100 (a)
(Bos Taurus)
Mammalia TRIM39 35
  • 94.06 (n)
  • 99.39 (a)
(Canis familiaris)
Mammalia TRIM39 35
  • 94.33 (n)
  • 99.39 (a)
TRIM39 36
  • 99 (a)
(Mus musculus)
Mammalia Trim39 35
  • 90.44 (n)
  • 97.54 (a)
Trim39 16
Trim39 36
  • 98 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Trim39 35
  • 89.48 (n)
  • 97.54 (a)
(Gallus gallus)
Aves TRIM27.1 36
  • 36 (a)
TRIM39 35
  • 52.94 (n)
  • 42.07 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
(Danio rerio)
Actinopterygii LOC101883816 35
  • 49.49 (n)
  • 38.24 (a)
Species with no ortholog for TRIM39:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM39 Gene

Gene Tree for TRIM39 (if available)
Gene Tree for TRIM39 (if available)

Paralogs for TRIM39 Gene Pseudogenes for TRIM39 Gene

genes like me logo Genes that share paralogs with TRIM39: view

Variants for TRIM39 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIM39 Gene

Variant ID Type Subtype PubMed ID
nsv5241 CNV Insertion 18451855

Relevant External Links for TRIM39 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TRIM39 Gene

Disorders for TRIM39 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TRIM39 Gene including...

Search for TRIM39 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TRIM39 Gene

Relevant External Links for TRIM39

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TRIM39: view

No data available for UniProtKB/Swiss-Prot for TRIM39 Gene

Publications for TRIM39 Gene

  1. Molecular cloning of testis-abundant finger protein/ring finger protein 23 (RNF23), a novel RING-B box-coiled coil-B30.2 protein on the class I region of the human MHC. (PMID: 11006080) Orimo A. … Muramatsu M. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23
  2. TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process. (PMID: 19100260) Lee S.S. … Yu V.C. (Exp. Cell Res. 2009) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. (PMID: 22529100) Huang N.J. … Kornbluth S. (J. Cell Biol. 2012) 3 4
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 48

Products for TRIM39 Gene

Sources for TRIM39 Gene

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