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Aliases for TRIM38 Gene

Aliases for TRIM38 Gene

  • Tripartite Motif Containing 38 2 3
  • Tripartite Motif-Containing Protein 38 3 4
  • Zinc Finger Protein RoRet 3 4
  • Ring Finger Protein 15 2 3
  • RNF15 3 4
  • RORET 3 4
  • E3 Ubiquitin-Protein Ligase TRIM38 3
  • Ro/SSA Ribonucleoprotein Homolog 3
  • Tripartite Motif-Containing 38 2
  • RING Finger Protein 15 4
  • EC 6.3.2.- 4

External Ids for TRIM38 Gene

Previous Symbols for TRIM38 Gene

  • RNF15

Summaries for TRIM38 Gene

Entrez Gene Summary for TRIM38 Gene

  • This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012]

GeneCards Summary for TRIM38 Gene

TRIM38 (Tripartite Motif Containing 38) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is TRIM58.

UniProtKB/Swiss-Prot for TRIM38 Gene

  • E3 ubiquitin-protein ligase. Mediates Lys-48-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM38 Gene

Genomics for TRIM38 Gene

Genomic Location for TRIM38 Gene

Start:
25,962,689 bp from pter
End:
25,987,329 bp from pter
Size:
24,641 bases
Orientation:
Plus strand

Genomic View for TRIM38 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM38 Gene

Regulatory Elements for TRIM38 Gene

Proteins for TRIM38 Gene

  • Protein details for TRIM38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00635-TRI38_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM38
    Protein Accession:
    O00635
    Secondary Accessions:
    • B2R862

    Protein attributes for TRIM38 Gene

    Size:
    465 amino acids
    Molecular mass:
    53416 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM38 Gene

Proteomics data for TRIM38 Gene at MOPED

Post-translational modifications for TRIM38 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys122, Lys137, and Lys227

Other Protein References for TRIM38 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM38 Gene

Domains for TRIM38 Gene

Gene Families for TRIM38 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

UniProtKB/Swiss-Prot:

TRI38_HUMAN
Domain:
  • Contains 1 B30.2/SPRY domain.:
    • O00635
Similarity:
  • Contains 1 B box-type zinc finger.:
    • O00635
  • Contains 1 RING-type zinc finger.:
    • O00635
genes like me logo Genes that share domains with TRIM38: view

Function for TRIM38 Gene

Molecular function for TRIM38 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase. Mediates Lys-48-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling.

Enzyme Numbers (IUBMB) for TRIM38 Gene

Gene Ontology (GO) - Molecular Function for TRIM38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRIM38: view

Phenotypes for TRIM38 Gene

GenomeRNAi human phenotypes for TRIM38:
genes like me logo Genes that share phenotypes with TRIM38: view

miRNA for TRIM38 Gene

miRTarBase miRNAs that target TRIM38

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIM38 Gene

Localization for TRIM38 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM38 Gene COMPARTMENTS Subcellular localization image for TRIM38 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TRIM38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRIM38: view

Pathways for TRIM38 Gene

SuperPathways for TRIM38 Gene

No Data Available

UniProtKB/Swiss-Prot O00635-TRI38_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIM38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0032648 regulation of interferon-beta production IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with TRIM38: view

No data available for Pathways by source for TRIM38 Gene

Transcripts for TRIM38 Gene

mRNA/cDNA for TRIM38 Gene

Unigene Clusters for TRIM38 Gene

Tripartite motif containing 38:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM38 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - -
SP2: -
SP3:
SP4: - -
SP5: - - -
SP6: -
SP7: - -
SP8:

Relevant External Links for TRIM38 Gene

GeneLoc Exon Structure for
TRIM38
ECgene alternative splicing isoforms for
TRIM38

Expression for TRIM38 Gene

mRNA expression in normal human tissues for TRIM38 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM38 Gene

This gene is overexpressed in Whole Blood (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRIM38 Gene

SOURCE GeneReport for Unigene cluster for TRIM38 Gene Hs.584851

mRNA Expression by UniProt/SwissProt for TRIM38 Gene

O00635-TRI38_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with TRIM38: view

Orthologs for TRIM38 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM38 36
  • 99.14 (n)
  • 98.92 (a)
TRIM38 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM38 36
  • 84.24 (n)
  • 76.47 (a)
TRIM38 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM38 36
  • 81.15 (n)
  • 71.49 (a)
TRIM38 37
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim38 36
  • 69.86 (n)
  • 57.17 (a)
Trim38 16
Trim38 37
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC680019 36
  • 64.04 (n)
  • 50.88 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 35 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 35 (a)
OneToMany
Species with no ortholog for TRIM38:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM38 Gene

ENSEMBL:
Gene Tree for TRIM38 (if available)
TreeFam:
Gene Tree for TRIM38 (if available)

Paralogs for TRIM38 Gene

Pseudogenes.org Pseudogenes for TRIM38 Gene

genes like me logo Genes that share paralogs with TRIM38: view

Variants for TRIM38 Gene

Sequence variations from dbSNP and Humsavar for TRIM38 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs10317 - 25,983,550(+) AGGCC(A/G)GAGTT missense, reference, nc-transcript-variant
rs115810 -- 25,975,655(-) GGAGA(C/G)GGGTG intron-variant, nc-transcript-variant
rs129129 -- 25,960,801(-) tcctt(C/T)ctata upstream-variant-2KB
rs169222 -- 25,986,693(-) ggaga(G/T)aaata utr-variant-3-prime
rs183879 -- 25,987,213(-) GCGGG(C/G)GGGGG utr-variant-3-prime

Relevant External Links for TRIM38 Gene

HapMap Linkage Disequilibrium report
TRIM38

No data available for Structural Variations from Database of Genomic Variants (DGV) for TRIM38 Gene

Disorders for TRIM38 Gene

Relevant External Links for TRIM38

Genetic Association Database (GAD)
TRIM38
Human Genome Epidemiology (HuGE) Navigator
TRIM38
genes like me logo Genes that share disorders with TRIM38: view

No data available for UniProtKB/Swiss-Prot for TRIM38 Gene

Publications for TRIM38 Gene

  1. A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PMID: 9149941) Ruddy D.A. … Feder J.N. (Genome Res. 1997) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (PMID: 19084217) Benyamin B. … Visscher P.M. (Am. J. Hum. Genet. 2009) 3 49
  4. TRIM38 negatively regulates TLR3-mediated IFN-I^ signaling by targeting TRIF for degradation. (PMID: 23056470) Xue Q. … Hung T. (PLoS ONE 2012) 3 4
  5. TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. (PMID: 23077300) Uchil P.D. … Mothes W. (J. Virol. 2013) 3

Products for TRIM38 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TRIM38
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM38
    • Block miRNA regulation of TRIM38 using miScript Target Protectors

    Sources for TRIM38 Gene

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