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TRIM37 Gene

protein-coding   GIFtS: 64
GCID: GC17M057059

Tripartite Motif Containing 37

(Previous name: tripartite motif-containing 37)
(Previous symbol: MUL)
  See TRIM37-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 371 2     KIAA08983 5
MUL1 2 3 5     Tripartite Motif-Containing 371
RING-B-Box-Coiled-Coil Protein1 2     TEF32
Mulibrey Nanism Protein2 3     E3 Ubiquitin-Protein Ligase TRIM372
Tripartite Motif-Containing Protein 372 3     EC 6.3.2.-3
POB12 3     

External Ids:    HGNC: 75231   Entrez Gene: 45912   Ensembl: ENSG000001083957   OMIM: 6050735   UniProtKB: O949723   

Export aliases for TRIM37 gene to outside databases

Previous GC identifers: GC17M056903 GC17M059637 GC17M057401 GC17M057549 GC17M054430 GC17M054414 GC17M052420


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIM37 Gene:
This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular
functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING
finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might
be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with
mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of
mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TRIM37 Gene:
TRIM37 (tripartite motif containing 37) is a protein-coding gene. Diseases associated with TRIM37 include mulibrey nanism, and ovarian fibrothecoma. GO annotations related to this gene include protein homodimerization activity and ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot: TRI37_HUMAN, O94972
Function: E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating
positive regulators of centriole reduplication

Gene Wiki entry for TRIM37 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM37 gene promoter:
         Tal-1   p53   SREBP-1c   CUTL1   E47   SREBP-1b   SREBP-1a   Cart-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM37 promoter sequence
   Search Chromatin IP Primers for TRIM37

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q

TRIM37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM37 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M057059:  view genomic region     (about GC identifiers)

Start:
57,059,999 bp from pter      End:
57,184,282 bp from pter
Size:
124,284 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRI37_HUMAN, O94972 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM37  
Size: 964 amino acids; 107906 Da
Sequence caution: Sequence=BAA74921.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for TRIM37:
3LRQ (3D)    
Secondary accessions: Q7Z3E6 Q8IYF7 Q8WYF7
Alternative splicing: 2 isoforms:  O94972-1   O94972-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIM37: NX_O94972

Explore proteomics data for TRIM37 at MOPED

Post-translational modifications: 

  • Auto-ubiquitinated1
  • Ubiquitination2 at Lys742
  • Modification sites at PhosphoSitePlus

  • See TRIM37 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001005207.1  NP_056109.1  

    ENSEMBL proteins: 
     ENSP00000464666   ENSP00000462778   ENSP00000376785   ENSP00000462340   ENSP00000262294  
     ENSP00000376784   ENSP00000462863   ENSP00000464590   ENSP00000464688   ENSP00000464263  
     ENSP00000365319  
    Reactome Protein details: O94972

    TRIM37 Human Recombinant Protein Products:

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    Novus Biologicals TRIM37 Protein
    Novus Biologicals TRIM37 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for TRIM37

     
    Search eBioscience for Proteins for TRIM37 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 6):
     IPR003649 Bbox_C
     IPR008974 TRAF-like
     IPR002083 MATH
     IPR001841 Znf_RING
     IPR000315 Znf_B-box

    Graphical View of Domain Structure for InterPro Entry O94972

    ProtoNet protein and cluster: O94972

    4 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB002083 Meprin/TRAF-like MATH
    IPB003649 B-box


    UniProtKB/Swiss-Prot: TRI37_HUMAN, O94972
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 MATH domain
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with TRIM37           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI37_HUMAN, O94972
    Function: E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating
    positive regulators of centriole reduplication

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA15885686
    GO:0005164tumor necrosis factor receptor binding IPI11279055
    GO:0005515protein binding IPI11279055
    GO:0008270zinc ion binding IEA--
    GO:0031625ubiquitin protein ligase binding IPI11279055
         
    Find genes that share ontologies with TRIM37           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRIM37:
     Increased S DNA content  S arrest 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM37
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM37
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM37

    miRNA
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    miRTarBase miRNAs that target TRIM37:
    hsa-mir-183-5p (MIRT047093), hsa-mir-769-3p (MIRT039127), hsa-mir-124-3p (MIRT022999), hsa-mir-30e-3p (MIRT044117)

    Block miRNA regulation of human, mouse, rat TRIM37 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM37 (see all 42):
    hsa-miR-106a hsa-miR-15a hsa-miR-503 hsa-miR-29a hsa-miR-301a hsa-miR-519a hsa-miR-424 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidTRIM37 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRIM37

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    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM37 (NM_015294)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM37
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM37

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM37


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRI37_HUMAN, O94972: Cytoplasm, perinuclear region. Peroxisome. Note=Found in vesicles of the peroxisome.
    Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for
    proteasomal degradation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    peroxisome5
    nucleus3
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0005777peroxisome IDA11938494
    GO:0005829cytosol IDA11279055
    GO:0016235aggresome IDA15885686

    Find genes that share ontologies with TRIM37           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRIM37 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35


    Find genes that share SuperPaths with TRIM37           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for TRIM37
        Antigen processing: Ubiquitination & Proteasome degradation


    1 Kegg Pathway  (Kegg details for TRIM37):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: TRI37_HUMAN, O94972
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM37: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TRIM37

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRIM37 (O949721, 2, 3 ENSP000002622944) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRC1O436631, 2, 3, ENSP000003777934EBI-741602,EBI-741137 MINT-67438 I2D: score=6 STRING: ENSP00000377793
    APTXQ7Z2E32, 3, ENSP000004008064MINT-2860941 MINT-2860960 I2D: score=3 STRING: ENSP00000400806
    APEX2Q9UBZ42, 3, ENSP000003641264MINT-66277 I2D: score=5 STRING: ENSP00000364126
    BYSLQ138952, 3, ENSP000002303404MINT-66930 I2D: score=5 STRING: ENSP00000230340
    FAM107AO959902, 3, ENSP000003542704MINT-66452 I2D: score=5 STRING: ENSP00000354270
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032088negative regulation of NF-kappaB transcription factor activity IDA11279055
    GO:0046600negative regulation of centriole replication IMP--
    GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity IDA--
    GO:0051092positive regulation of NF-kappaB transcription factor activity IDA--
    GO:0051865protein autoubiquitination IDA15885686

    Find genes that share ontologies with TRIM37           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM37 (TRI37)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRIM37 gene (2 alternative transcripts): 
    NM_001005207.2  NM_015294.3  

    Unigene Cluster for TRIM37:

    Tripartite motif containing 37
    Hs.579079  [show with all ESTs]
    Unigene Representative Sequence: NM_015294
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585287 ENST00000583945 ENST00000393066(uc002iwy.4) ENST00000577554
    ENST00000262294 ENST00000393065 ENST00000581468 ENST00000582852 ENST00000580973
    ENST00000580122 ENST00000580620 ENST00000583387 ENST00000584889 ENST00000376149(uc002iwz.4 uc002ixa.4 uc010woc.2)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TRIM37 (see all 42):
    hsa-miR-106a hsa-miR-15a hsa-miR-503 hsa-miR-29a hsa-miR-301a hsa-miR-519a hsa-miR-424 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidTRIM37 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM37 (NM_015294)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM37
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM37
      QuantiTect SYBR Green Assays in human, mouse, rat TRIM37
      QuantiFast Probe-based Assays in human, mouse, rat TRIM37

    Additional mRNA sequence: 

    AB020705.1 AF213365.1 AK022701.1 AK025648.1 AK289674.1 AK292459.1 AK294850.1 BC036012.1 
    BX537955.1 

    18 DOTS entries:

    DT.456338  DT.97843497  DT.91723801  DT.95252077  DT.120930631  DT.314049  DT.91723799  DT.100693863 
    DT.100794522  DT.91723787  DT.97843499  DT.120930369  DT.120930495  DT.86846390  DT.91723786  DT.91723788 
    DT.314344  DT.75106535 

    Selected AceView cDNA sequences (see all 145):

    AU125638 AB020705 NM_001005207 AL560678 BU634524 CR621658 AW103703 BU678156 
    AI699757 AI382965 BG681041 AW118387 CB163050 Z38860 BM471820 BF511737 
    AV715627 AL135214 AA411819 AI080375 BQ278933 AI339566 BX492275 CB135536 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRIM37 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
    SP1:                                      -           -     -                                               -                                                   
    SP2:                                                  -     -                                               -                                                   
    SP3:                          -           -           -     -                                                                                                   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
    SP1:                                      -                     
    SP2:                                      -     -               
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for TRIM37

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM37 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGAGACAT
    TRIM37 Expression
    About this image


    TRIM37 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord
    TRIM37 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM37 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.579079

    UniProtKB/Swiss-Prot: TRI37_HUMAN, O94972
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM37: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM37

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM37 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim371 , 5 tripartite motif-containing 371, 5 88.75(n)1
    92.92(a)1
      11 (51.93 cM)5
    687291  NM_197987.21  NP_932104.11 
     871270775 
    chicken
    (Gallus gallus)
    Aves TRIM371 tripartite motif containing 37 75.28(n)
    81.56(a)
      417628  NM_001006224.1  NP_001006224.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRIM376
    tripartite motif containing 37
    77(a)
    1 ↔ 1
    GL343684.1(269862-322481)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.35372 Transcribed sequence with strong similarity to protein refNP_056109.1 (H.sapiens) tripartite motif-containing 37; RING-B-box-coiled-coil protein; MUL protein; Mulibrey nanism [Homo sapiens] less 78.76(n)    AL853018.2 
    zebrafish
    (Danio rerio)
    Actinopterygii trim371 tripartite motif containing 37 63.24(n)
    68(a)
      324237  XM_003199359.2  XP_003199407.2 


    ENSEMBL Gene Tree for TRIM37 (if available)
    TreeFam Gene Tree for TRIM37 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM37 gene
    1 SIMAP similar gene for TRIM37 using alignment to 10 protein entries:     TRI37_HUMAN (see all proteins):
    RAD18

    Find genes that share paralogs with TRIM37           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM37 (see all 2244)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0602174
    Mulibrey nanism (MUL)4--see VAR_0602172 L P mis40--------
    VAR_0602204
    Mulibrey nanism (MUL)4--see VAR_0602202 G V mis40--------
    VAR_0602194
    Mulibrey nanism (MUL)4--see VAR_0602192 C S mis40--------
    rs607699051,2
    C--57063253(+) GAAAG-/AAGGACAT 1 -- int10--------
    rs711455101,2
    C--57068537(+) AAAAAA/-GAAAA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs588826311,2
    C--57069621(+) ATATA-/TAAATAT 1 -- int11Minor allele frequency- TA:0.00NA 2
    rs352220791,2
    C--57069684(+) TGTAA-/ATATATA 1 -- int10--------
    rs1128529541,2
    C,F--57070535(+) AGATGT/GGCCTT 1 -- int12Minor allele frequency- G:0.11CSA WA 119
    rs600938121,2
    C--57071160(+) AGGAT-/ATGTGGG 1 -- int10--------
    rs346270441,2
    C--57074169(+) TGTGT-/GTGTGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TRIM37 (57059999 - 57184282 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TRIM37 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2421884CNV Deletion20811451
    esv2675820CNV Deletion23128226
    nsv507849CNV Insertion20534489
    nsv510719CNV Loss20534489
    nsv908644CNV Loss21882294
    nsv828069CNV Loss20364138
    dgv3237n71CNV Loss21882294
    nsv833499CNV Loss17160897
    dgv3236n71CNV Loss21882294
    nsv514855CNV Loss21397061

    Human Gene Mutation Database (HGMD): TRIM37
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM37
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM37

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605073   
    OMIM disorders: 253250  
    UniProtKB/Swiss-Prot: TRI37_HUMAN, O94972
  • Mulibrey nanism (MUL) [MIM:253250]: Autosomal recessive disorder that involves several tissues of
    mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth
    failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle
    hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia
    of various endocrine glands causing hormonal deficiency are common. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 2 diseases for TRIM37:    
    About MalaCards
    mulibrey nanism    ovarian fibrothecoma

    3 diseases from the University of Copenhagen DISEASES database for TRIM37:
    Mulibrey nanism     Acquired immunodeficiency syndrome     Malaria

    Find genes that share disorders with TRIM37           About GenesLikeMe

    8 Novoseek inferred disease relationships for TRIM37 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nanism mulibrey 99.3 26 15108285 (3), 11938494 (3), 19329943 (3), 16514549 (2) (see all 10)
    growth disorders 85.1 2 11938494 (1), 19329943 (1)
    growth failure 82.7 2 16514549 (1), 16310976 (1)
    peroxisomal disorders 81.7 3 11938494 (2), 15108285 (1)
    hepatomegaly 61.2 1 16310976 (1)
    heart diseases 41.9 1 16514549 (1)
    necrosis 0 1 17100991 (1)
    tumors 0 7 19329943 (2), 17100991 (1)


    Export disorders for TRIM37 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM37 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with TRIM37)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene encoding a new RING-B-box-coiled-coil protein is mutated in mulibrey nanism. (PubMed id 10888877)1, 2, 3 Avela K.... Lehesjoki A.E. (Nat. Genet. 2000)
    2. The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder. (PubMed id 11938494)1, 2, 9 Kallijarvi J....Lehesjoki A.E. (Am. J. Hum. Genet. 2002)
    3. Novel mutations in the TRIM37 gene in Mulibrey Nanism. (PubMed id 15108285)1, 2, 9 Haemaelaeinen R.H....Lehesjoki A.E. (Hum. Mutat. 2004)
    4. Wilms' tumor and novel TRIM37 mutations in an Australian patient with mulibrey nanism. (PubMed id 17100991)1, 2, 9 Haemaelaeinen R.H.... Lehesjoki A.-E. (Clin. Genet. 2006)
    5. A novel splice site mutation in the TRIM37 gene causes mulibrey nanism in a Turkish family with phenotypic heterogeneity. (PubMed id 12754710)1, 2, 9 Jagiello P.... Gencik M. (Hum. Mutat. 2003)
    6. TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase. (PubMed id 15885686)1, 2 Kallijaervi J.... Lehesjoki A.-E. (Exp. Cell Res. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    9. Assignment of the mulibrey nanism gene to 17q by linkage and linkage-disequilibrium analysis. (PubMed id 9106536)1, 3 Avela K....Lehesjoki A.E. (Am. J. Hum. Genet. 1997)
    10. Gynecological tumors in Mulibrey nanism and role for RING finger protein TRIM37 in the pathogenesis of ovarian fibrothecomas. (PubMed id 19329943)1, 9 Karlberg S....Butzow R. (Mod. Pathol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4591 HGNC: 7523 AceView: TRIM37 Ensembl:ENSG00000108395 euGenes: HUgn4591
    ECgene: TRIM37 Kegg: 4591 H-InvDB: TRIM37

    (According to HUGE)
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    HUGE: KIAA0898

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRIM37 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRIM37 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=TRIM37[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM37 gene:
    Search GeneIP for patents involving TRIM37

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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