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Aliases for TRIM37 Gene

Aliases for TRIM37 Gene

  • Tripartite Motif Containing 37 2 3
  • MUL 3 4 6
  • Tripartite Motif-Containing Protein 37 3 4
  • RING-B-Box-Coiled-Coil Protein 2 3
  • Mulibrey Nanism Protein 3 4
  • KIAA0898 4 6
  • POB1 3 4
  • E3 Ubiquitin-Protein Ligase TRIM37 3
  • Tripartite Motif-Containing 37 2
  • EC 6.3.2.- 4
  • TEF3 3

External Ids for TRIM37 Gene

Previous Symbols for TRIM37 Gene

  • MUL

Summaries for TRIM37 Gene

Entrez Gene Summary for TRIM37 Gene

  • This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM37 Gene

TRIM37 (Tripartite Motif Containing 37) is a Protein Coding gene. Diseases associated with TRIM37 include mulibrey nanism and ovarian fibrothecoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include protein homodimerization activity and ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot for TRIM37 Gene

  • E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of Lys-119 of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724).

Gene Wiki entry for TRIM37 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM37 Gene

Genomics for TRIM37 Gene

Genomic Location for TRIM37 Gene

Start:
58,982,638 bp from pter
End:
59,106,921 bp from pter
Size:
124,284 bases
Orientation:
Minus strand

Genomic View for TRIM37 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM37 Gene

Regulatory Elements for TRIM37 Gene

Proteins for TRIM37 Gene

  • Protein details for TRIM37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94972-TRI37_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM37
    Protein Accession:
    O94972
    Secondary Accessions:
    • A8K0V9
    • A8K8U4
    • A8MZ79
    • B4DGZ3
    • F8WEE6
    • Q7Z3E6
    • Q8IYF7
    • Q8WYF7

    Protein attributes for TRIM37 Gene

    Size:
    964 amino acids
    Molecular mass:
    107906 Da
    Quaternary structure:
    • Associates with the PRC2/EED-EZH2 complex.
    Miscellaneous:
    • Acts as a proto-oncogene via its ability to monoubiquinate Lys-119 of histone H2A (H2AK119Ub): overexpressed in a number of breast cancers and promotes transformation of cells by mediating silencing of tumor suppressor genes (PubMed:25470042).
    SequenceCaution:
    • Sequence=BAA74921.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM37 Gene

    Alternative splice isoforms for TRIM37 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM37 Gene

Proteomics data for TRIM37 Gene at MOPED

Post-translational modifications for TRIM37 Gene

No data available for DME Specific Peptides for TRIM37 Gene

Domains for TRIM37 Gene

Gene Families for TRIM37 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Graphical View of Domain Structure for InterPro Entry

O94972

UniProtKB/Swiss-Prot:

TRI37_HUMAN
Domain:
  • Contains 1 MATH domain.:
    • O94972
Family:
  • Belongs to the TRIM/RBCC family.:
    • O94972
Similarity:
  • Contains 1 B box-type zinc finger.:
    • O94972
  • Contains 1 RING-type zinc finger.:
    • O94972
genes like me logo Genes that share domains with TRIM37: view

Function for TRIM37 Gene

Molecular function for TRIM37 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of Lys-119 of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724).
UniProtKB/Swiss-Prot Induction: Overexpressed in a number of breast cancer cell lines.

Enzyme Numbers (IUBMB) for TRIM37 Gene

Gene Ontology (GO) - Molecular Function for TRIM37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0004842 ubiquitin-protein transferase activity IDA 15885686
GO:0005164 tumor necrosis factor receptor binding IPI 11279055
GO:0005515 protein binding IPI 11279055
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM37: view

Phenotypes for TRIM37 Gene

GenomeRNAi human phenotypes for TRIM37:
genes like me logo Genes that share phenotypes with TRIM37: view

miRNA for TRIM37 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIM37 Gene

Localization for TRIM37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM37 Gene

Cytoplasm, perinuclear region. Peroxisome. Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. {ECO:0000269 PubMed:15885686}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM37 Gene COMPARTMENTS Subcellular localization image for TRIM37 gene
Compartment Confidence
cytosol 5
peroxisome 5
nucleus 3
extracellular 2

Gene Ontology (GO) - Cellular Components for TRIM37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA 23769972
GO:0005777 peroxisome IDA 11938494
GO:0005829 cytosol IDA 11279055
GO:0016235 aggresome IDA 15885686
genes like me logo Genes that share ontologies with TRIM37: view

Pathways for TRIM37 Gene

genes like me logo Genes that share pathways with TRIM37: view

UniProtKB/Swiss-Prot O94972-TRI37_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 25470042
GO:0006351 transcription, DNA-templated IEA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 11279055
GO:0035518 histone H2A monoubiquitination IDA 25470042
GO:0036353 histone H2A-K119 monoubiquitination IDA 25470042
genes like me logo Genes that share ontologies with TRIM37: view

Transcripts for TRIM37 Gene

Unigene Clusters for TRIM37 Gene

Tripartite motif containing 37:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM37 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4:
SP5:
SP6:
SP7: - - - - - -
SP8: -
SP9:

ExUns: 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
SP1: -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -

Relevant External Links for TRIM37 Gene

GeneLoc Exon Structure for
TRIM37
ECgene alternative splicing isoforms for
TRIM37

Expression for TRIM37 Gene

mRNA expression in normal human tissues for TRIM37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM37 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM37 Gene

SOURCE GeneReport for Unigene cluster for TRIM37 Gene Hs.579079

mRNA Expression by UniProt/SwissProt for TRIM37 Gene

O94972-TRI37_HUMAN
Tissue specificity: Ubiquitous (PubMed:10888877). Highly expressed in testis, while it is weakly expressed in other tissues (PubMed:16310976).
genes like me logo Genes that share expressions with TRIM37: view

Orthologs for TRIM37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM37 35
  • 99.65 (n)
  • 99.69 (a)
TRIM37 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM37 35
  • 91.22 (n)
  • 93.75 (a)
TRIM37 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM37 35
  • 92.72 (n)
  • 95.11 (a)
TRIM37 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim37 35
  • 88.75 (n)
  • 92.92 (a)
Trim37 16
Trim37 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM37 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Trim37 35
  • 88.54 (n)
  • 92.81 (a)
chicken
(Gallus gallus)
Aves TRIM37 35
  • 75.28 (n)
  • 81.56 (a)
TRIM37 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM37 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3537 35
trim37 35
  • 70.37 (n)
  • 75.64 (a)
zebrafish
(Danio rerio)
Actinopterygii trim37 35
  • 63.24 (n)
  • 68 (a)
trim37 36
  • 66 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7142 36
  • 63 (a)
OneToOne
Species with no ortholog for TRIM37:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM37 Gene

ENSEMBL:
Gene Tree for TRIM37 (if available)
TreeFam:
Gene Tree for TRIM37 (if available)

Paralogs for TRIM37 Gene

Selected SIMAP similar genes for TRIM37 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with TRIM37: view

No data available for Paralogs for TRIM37 Gene

Variants for TRIM37 Gene

Sequence variations from dbSNP and Humsavar for TRIM37 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs914 -- 58,998,352(+) ATGTA(C/T)ATTTA intron-variant, utr-variant-3-prime
rs972849 -- 59,062,943(-) ATTAA(A/T)TTTGG intron-variant
rs1182112 -- 58,992,456(+) gttca(C/T)ggcaa intron-variant
rs1509345 -- 59,003,261(+) TGTTT(C/T)TACTG intron-variant
rs1509346 -- 59,003,444(+) AGGTT(C/T)TAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM37 Gene

Variant ID Type Subtype PubMed ID
dgv3236n71 CNV Loss 21882294
nsv908644 CNV Loss 21882294
nsv510719 CNV Loss 20534489
nsv908646 CNV Loss 21882294
nsv833499 CNV Loss 17160897
dgv995e1 CNV Complex 17122850
nsv9574 CNV Loss 18304495
esv2675820 CNV Deletion 23128226
nsv828068 CNV Loss 20364138
nsv514855 CNV Loss 21397061
esv2421884 CNV Deletion 20811451
nsv507849 CNV Insertion 20534489
dgv3237n71 CNV Loss 21882294
nsv828069 CNV Loss 20364138

Relevant External Links for TRIM37 Gene

HapMap Linkage Disequilibrium report
TRIM37
Human Gene Mutation Database (HGMD)
TRIM37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM37 Gene

Disorders for TRIM37 Gene

(1) OMIM Diseases for TRIM37 Gene (605073)

UniProtKB/Swiss-Prot

TRI37_HUMAN
  • Mulibrey nanism (MUL) [MIM:253250]: An autosomal recessive growth disorder characterized by severe growth failure of prenatal onset, constrictive pericardium and progressive cardiomyopathy, facial dysmorphism, and failure of sexual maturation. Additional clinical features include hepatomegaly, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, hypoplasia of various endocrine glands, insulin resistance with type 2 diabetes, and an increased risk for Wilms tumor. {ECO:0000269 PubMed:10888877, ECO:0000269 PubMed:12754710, ECO:0000269 PubMed:15108285, ECO:0000269 PubMed:15885686, ECO:0000269 PubMed:17100991, ECO:0000269 PubMed:17551331, ECO:0000269 PubMed:21865362, ECO:0000269 PubMed:23385855}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for TRIM37 Gene

(8) Novoseek inferred disease relationships for TRIM37 Gene

Disease -log(P) Hits PubMed IDs
nanism mulibrey 99.3 18
growth disorders 85.1 2
growth failure 82.7 2
peroxisomal disorders 81.7 3
hepatomegaly 61.2 1
genes like me logo Genes that share disorders with TRIM37: view

Publications for TRIM37 Gene

  1. The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder. (PMID: 11938494) Kallijarvi J. … Lehesjoki A.E. (Am. J. Hum. Genet. 2002) 3 4 23
  2. A novel splice site mutation in the TRIM37 gene causes mulibrey nanism in a Turkish family with phenotypic heterogeneity. (PMID: 12754710) Jagiello P. … Gencik M. (Hum. Mutat. 2003) 3 4 23
  3. Novel mutations in the TRIM37 gene in Mulibrey Nanism. (PMID: 15108285) Haemaelaeinen R.H. … Lehesjoki A.E. (Hum. Mutat. 2004) 3 4 23
  4. Wilms' tumor and novel TRIM37 mutations in an Australian patient with mulibrey nanism. (PMID: 17100991) Haemaelaeinen R.H. … Lehesjoki A.-E. (Clin. Genet. 2006) 3 4 23
  5. A novel mutation in TRIM37 is associated with mulibrey nanism in a Turkish boy. (PMID: 17551331) DoA9anc T. … Tekin M. (Clin. Dysmorphol. 2007) 3 4 23

Products for TRIM37 Gene

Sources for TRIM37 Gene

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