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TRIM37 Gene

protein-coding GIFtS: 64
GCID: GC17M057059

Tripartite Motif Containing 37

(Previous name: tripartite motif-containing 37)
(Previous symbol: MUL)

See TRIM37-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Tripartite Motif Containing 37¹ ²		KIAA0898³ ⁵
MUL¹ ² ³ ⁵		Tripartite Motif-Containing 37¹
RING-B-Box-Coiled-Coil Protein¹ ²		TEF3²
Mulibrey Nanism Protein² ³		E3 Ubiquitin-Protein Ligase TRIM37²
Tripartite Motif-Containing Protein 37² ³		EC 6.3.2.-³
POB1² ³

External Ids:	HGNC: 7523¹	Entrez Gene: 4591²	Ensembl: ENSG00000108395⁷	OMIM: 605073⁵	UniProtKB: O94972³

Export aliases for TRIM37 gene to outside databases

Previous GC identifers: GC17M056903 GC17M059637 GC17M057401 GC17M057549 GC17M054430 GC17M054414 GC17M052420

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIM37 Gene:

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular

functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING

finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might

be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with

mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of

mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified.

(provided by RefSeq, Jul 2008)

GeneCards Summary for TRIM37 Gene:

TRIM37 (tripartite motif containing 37) is a protein-coding gene. Diseases associated with TRIM37 include mulibrey nanism, and ovarian fibrothecoma. GO annotations related to this gene include protein homodimerization activity and ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot: TRI37_HUMAN, O94972

Function: E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating

positive regulators of centriole reduplication

Gene Wiki entry for TRIM37 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000017.10 NT_010783.16 NC_018928.2

Regulatory elements:

Regulatory transcription factor binding sites in the TRIM37 gene promoter:
Tal-1 p53 SREBP-1c CUTL1 E47 SREBP-1b SREBP-1a Cart-1 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRIM37 promoter sequence

Search Chromatin IP Primers for TRIM37

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM37

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2 Ensembl cytogenetic band: 17q22 HGNC cytogenetic band: 17q

TRIM37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM37 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M057059: view genomic region (about GC identifiers)

Start:	57,059,999 bp from pter	End:	57,184,282 bp from pter
Size:	124,284 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TRI37_HUMAN, O94972 (See protein sequence)

Recommended Name: E3 ubiquitin-protein ligase TRIM37

Size: 964 amino acids; 107906 Da

Sequence caution: Sequence=BAA74921.1; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for TRIM37:

3LRQ (3D)

Secondary accessions: Q7Z3E6 Q8IYF7 Q8WYF7

Alternative splicing: 2 isoforms: O94972-1 O94972-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIM37: NX_O94972

Explore proteomics data for TRIM37 at MOPED

Post-translational modifications:

Auto-ubiquitinated¹

Ubiquitination² at Lys742

Modification sites at PhosphoSitePlus

See TRIM37 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001005207.1 NP_056109.1

ENSEMBL proteins:

ENSP00000464666 ENSP00000462778 ENSP00000376785 ENSP00000462340 ENSP00000262294

ENSP00000376784 ENSP00000462863 ENSP00000464590 ENSP00000464688 ENSP00000464263

ENSP00000365319

Reactome Protein details: O94972

TRIM37 Human Recombinant Protein Products:

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	Novus Biologicals TRIM37 Protein Novus Biologicals TRIM37 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for TRIM37
	Search eBioscience for Proteins for TRIM37
	antibodies-online proteins for TRIM37 (2 products)
	antibodies-online peptides for TRIM37

TRIM37 Antibody Products:

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	antibodies-online antibodies for TRIM37 (31 products)

TRIM37 Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for TRIM37
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for TRIM37 Cloud-Clone Corp. CLIAs for TRIM37
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	antibodies-online kits for TRIM37 (4 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

TRIM: Tripartite motif containing / Tripartite motif containing

RNF: RING-type (C3HC4) zinc fingers

Selected InterPro protein domains (see all 6):

IPR003649 Bbox_C

IPR008974 TRAF-like

IPR002083 MATH

IPR001841 Znf_RING

IPR000315 Znf_B-box

Graphical View of Domain Structure for InterPro Entry O94972

ProtoNet protein and cluster: O94972

4 Blocks protein domains:

IPB000315 B-box zinc finger signature

IPB001841 Zn-finger

IPB002083 Meprin/TRAF-like MATH

IPB003649 B-box

UniProtKB/Swiss-Prot: TRI37_HUMAN, O94972

Similarity: Belongs to the TRIM/RBCC family

Similarity: Contains 1 B box-type zinc finger

Similarity: Contains 1 MATH domain

Similarity: Contains 1 RING-type zinc finger

Find genes that share domains with TRIM37 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: TRI37_HUMAN, O94972

Function: E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating

positive regulators of centriole reduplication

Enzyme Number (IUBMB): EC 6.3.2.-¹

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IDA	15885686
GO:0005164	tumor necrosis factor receptor binding	IPI	11279055
GO:0005515	protein binding	IPI	11279055
GO:0008270	zinc ion binding	IEA	--
GO:0031625	ubiquitin protein ligase binding	IPI	11279055

Find genes that share ontologies with TRIM37 About GenesLikeMe

Phenotypes:
2 GenomeRNAi human phenotypes for TRIM37:

Increased S DNA content

S arrest

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for TRIM37

miRNA Products:		miRTarBase miRNAs that target TRIM37: hsa-mir-183-5p (MIRT047093), hsa-mir-769-3p (MIRT039127), hsa-mir-124-3p (MIRT022999), hsa-mir-30e-3p (MIRT044117)

		Block miRNA regulation of human, mouse, rat TRIM37 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TRIM37 (see all 42):
		hsa-miR-106a hsa-miR-15a hsa-miR-503 hsa-miR-29a hsa-miR-301a hsa-miR-519a hsa-miR-424 hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: TRIM37 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TRIM37
		Predesigned siRNA for gene silencing in human, mouse, rat TRIM37

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TRIM37

Clone Products:		OriGene clones in human, mouse for TRIM37 (see all 11) OriGene ORF clones in mouse, rat for TRIM37 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TRIM37 (NM_015294)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM37
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM37

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TRIM37
		Browse ESI BIO Cell Lines and PureStem Progenitors for TRIM37

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM37

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

TRI37_HUMAN, O94972: Cytoplasm, perinuclear region. Peroxisome. Note=Found in vesicles of the peroxisome.

Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for

proteasomal degradation

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	5
peroxisome	5
nucleus	3
extracellular	2

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Gene Ontology (GO): Selected cellular component terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	IDA	--
GO:0005777	peroxisome	IDA	11938494
GO:0005829	cytosol	IDA	11279055
GO:0016235	aggresome	IDA	15885686

Find genes that share ontologies with TRIM37 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TRIM37 About

See pathways by source

Powered
by

SuperPath

Contained pathways About

Class I MHC mediated antigen processing and presentation

	Class I MHC mediated antigen processing and presentation	0.84			Adaptive Immune System	0.41
	Antigen processing- Ubiquitination and Proteasome degradation	0.84			Ubiquitin mediated proteolysis	0.35

Find genes that share SuperPaths with TRIM37 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 Reactome Pathway for TRIM37

Antigen processing: Ubiquitination & Proteasome degradation

1 Kegg Pathway (Kegg details for TRIM37):

Ubiquitin mediated proteolysis

UniProtKB/Swiss-Prot: TRI37_HUMAN, O94972

Pathway: Protein modification; protein ubiquitination

Pathway & Disease-focused RT² Profiler PCR Array including TRIM37:

Ubiquitin Ligases in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for TRIM37

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for TRIM37 (O94972^{1, 2, 3} ENSP00000262294⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 62)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRC1	O43663¹^,²^,³, ENSP00000377793⁴	EBI-741602,EBI-741137 MINT-67438 I2D: score=6 STRING: ENSP00000377793
APTX	Q7Z2E3²^,³, ENSP00000400806⁴	MINT-2860941 MINT-2860960 I2D: score=3 STRING: ENSP00000400806
APEX2	Q9UBZ4²^,³, ENSP00000364126⁴	MINT-66277 I2D: score=5 STRING: ENSP00000364126
BYSL	Q13895²^,³, ENSP00000230340⁴	MINT-66930 I2D: score=5 STRING: ENSP00000230340
FAM107A	O95990²^,³, ENSP00000354270⁴	MINT-66452 I2D: score=5 STRING: ENSP00000354270

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Gene Ontology (GO): Selected biological process terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0032088	negative regulation of NF-kappaB transcription factor activity	IDA	11279055
GO:0046600	negative regulation of centriole replication	IMP	--
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	IDA	--
GO:0051092	positive regulation of NF-kappaB transcription factor activity	IDA	--
GO:0051865	protein autoubiquitination	IDA	15885686

Find genes that share ontologies with TRIM37 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for TRIM37 (TRI37)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TRIM37 gene (2 alternative transcripts):

NM_001005207.2 NM_015294.3

Unigene Cluster for TRIM37:

Tripartite motif containing 37

Hs.579079 [show with all ESTs]

Unigene Representative Sequence: NM_015294

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000585287 ENST00000583945 ENST00000393066(uc002iwy.4) ENST00000577554

ENST00000262294 ENST00000393065 ENST00000581468 ENST00000582852 ENST00000580973

ENST00000580122 ENST00000580620 ENST00000583387 ENST00000584889 ENST00000376149(uc002iwz.4 uc002ixa.4 uc010woc.2)

miRNA Products:		Block miRNA regulation of human, mouse, rat TRIM37 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TRIM37 (see all 42):
		hsa-miR-106a hsa-miR-15a hsa-miR-503 hsa-miR-29a hsa-miR-301a hsa-miR-519a hsa-miR-424 hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: TRIM37 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TRIM37
		Predesigned siRNA for gene silencing in human, mouse, rat TRIM37

Clone Products:		OriGene clones in human, mouse for TRIM37 (see all 11) OriGene ORF clones in mouse, rat for TRIM37 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TRIM37 (NM_015294)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM37
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM37

Primer Products:		OriGene qPCR primer pairs and template standards for TRIM37 OriGene qSTAR qPCR primer pairs in human, mouse for TRIM37
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat TRIM37
		QuantiTect SYBR Green Assays in human, mouse, rat TRIM37
		QuantiFast Probe-based Assays in human, mouse, rat TRIM37

Additional mRNA sequence:

AB020705.1 AF213365.1 AK022701.1 AK025648.1 AK289674.1 AK292459.1 AK294850.1 BC036012.1

BX537955.1

18 DOTS entries:

DT.456338 DT.97843497 DT.91723801 DT.95252077 DT.120930631 DT.314049 DT.91723799 DT.100693863

DT.100794522 DT.91723787 DT.97843499 DT.120930369 DT.120930495 DT.86846390 DT.91723786 DT.91723788

DT.314344 DT.75106535

Selected AceView cDNA sequences (see all 145):

AU125638 AB020705 NM_001005207 AL560678 BU634524 CR621658 AW103703 BU678156

AI699757 AI382965 BG681041 AW118387 CB163050 Z38860 BM471820 BF511737

AV715627 AL135214 AA411819 AI080375 BQ278933 AI339566 BX492275 CB135536

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRIM37 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19a	·
SP1:													-				-		-																-
SP2:																	-		-																-
SP3:									-				-				-		-
SP4:
SP5:

ExUns:	19b	^	20a	·	20b	^	21	^	22	^	23	^	24	^	25	^	26a	·	26b
SP1:													-
SP2:													-		-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for TRIM37

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TRIM37 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGAGAGACAT

About this image

TRIM37 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 2) fully expand


Testis (Reproductive System)
XY Germ Cells Testis Cord

Gonad
XY Germ Cells Testis Cord

TRIM37 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TRIM37 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.579079

UniProtKB/Swiss-Prot: TRI37_HUMAN, O94972

Tissue specificity: Ubiquitous

Pathway & Disease-focused RT² Profiler PCR Array including TRIM37:

Ubiquitin Ligases in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for TRIM37 OriGene qSTAR qPCR primer pairs in human, mouse for TRIM37
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat TRIM37
		QuantiTect SYBR Green Assays in human, mouse, rat TRIM37
		QuantiFast Probe-based Assays in human, mouse, rat TRIM37

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM37

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TRIM37 gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Trim37^{1 , 5}	tripartite motif-containing 37^{1, 5}	88.75(n)¹ 92.92(a)¹		11 (51.93 cM)⁵ 68729¹ NM_197987.2¹ NP_932104.1¹ 87127077⁵
chicken (Gallus gallus)	Aves	TRIM37¹	tripartite motif containing 37	75.28(n) 81.56(a)		417628 NM_001006224.1 NP_001006224.1
lizard (Anolis carolinensis)	Reptilia	TRIM37⁶	tripartite motif containing 37	77(a)	1 ↔ 1	GL343684.1(269862-322481)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.3537²	Transcribed sequence with strong similarity to protein refNP_056109.1 (H.sapiens) tripartite motif-containing 37; RING-B-box-coiled-coil protein; MUL protein; Mulibrey nanism [Homo sapiens] less	78.76(n)		AL853018.2
zebrafish (Danio rerio)	Actinopterygii	trim37¹	tripartite motif containing 37	63.24(n) 68(a)		324237 XM_003199359.2 XP_003199407.2

ENSEMBL Gene Tree for TRIM37 (if available)
TreeFam Gene Tree for TRIM37 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for TRIM37 gene

1 SIMAP similar gene for TRIM37 using alignment to 10 protein entries: TRI37_HUMAN (see all proteins):

RAD18

Find genes that share paralogs with TRIM37 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_060217⁴		Mulibrey nanism (MUL)⁴	--	see VAR_060217	2	L P	mis⁴		0	--	--	--	--
VAR_060220⁴		Mulibrey nanism (MUL)⁴	--	see VAR_060220	2	G V	mis⁴		0	--	--	--	--
VAR_060219⁴		Mulibrey nanism (MUL)⁴	--	see VAR_060219	2	C S	mis⁴		0	--	--	--	--
rs60769905^1,2	C	--	57063253(+)	`GAAAG-/AAGGACAT`	1	--	int¹		0	--	--	--	--
rs71145510^1,2	C	--	57068537(+)	`AAAAAA/-GAAAA`	1	--	int¹		1		NA	2
rs58882631^1,2	C	--	57069621(+)	`ATATA-/TAAATAT`	1	--	int¹		1		NA	2
rs35222079^1,2	C	--	57069684(+)	`TGTAA-/ATATATA`	1	--	int¹		0	--	--	--	--
rs112852954^1,2	C,F	--	57070535(+)	`AGATGT/GGCCTT`	1	--	int¹		2		CSA WA	119
rs60093812^1,2	C	--	57071160(+)	`AGGAT-/ATGTGGG`	1	--	int¹		0	--	--	--	--
rs34627044^1,2	C	--	57074169(+)	`TGTGT-/GTGTGT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRIM37 (57059999 - 57184282 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for TRIM37 (see all 14): About this table

Variant ID	Type	Subtype	PubMed ID
esv2421884	CNV	Deletion	20811451
esv2675820	CNV	Deletion	23128226
nsv507849	CNV	Insertion	20534489
nsv510719	CNV	Loss	20534489
nsv908644	CNV	Loss	21882294
nsv828069	CNV	Loss	20364138
dgv3237n71	CNV	Loss	21882294
nsv833499	CNV	Loss	17160897
dgv3236n71	CNV	Loss	21882294
nsv514855	CNV	Loss	21397061

Human Gene Mutation Database (HGMD): TRIM37

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605073
OMIM disorders: 253250
UniProtKB/Swiss-Prot: TRI37_HUMAN, O94972

Mulibrey nanism (MUL) [MIM:253250]: Autosomal recessive disorder that involves several tissues of

mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth

failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle

hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia

of various endocrine glands causing hormonal deficiency are common. Note=The disease is caused by mutations

affecting the gene represented in this entry

2 diseases for TRIM37:
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mulibrey nanism ovarian fibrothecoma

3 inferred disease relationships from the University of Copenhagen DISEASES database for TRIM37:

Mulibrey nanism Acquired immunodeficiency syndrome Malaria

Find genes that share disorders with TRIM37 About GenesLikeMe

8 Novoseek inferred disease relationships for TRIM37 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nanism mulibrey	99.3	26	15108285 (3), 11938494 (3), 19329943 (3), 16514549 (2) (see all 10)
growth disorders	85.1	2	11938494 (1), 19329943 (1)
growth failure	82.7	2	16514549 (1), 16310976 (1)
peroxisomal disorders	81.7	3	11938494 (2), 15108285 (1)
hepatomegaly	61.2	1	16310976 (1)
heart diseases	41.9	1	16514549 (1)
necrosis	0	1	17100991 (1)
tumors	0	7	19329943 (2), 17100991 (1)

Export disorders for TRIM37 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TRIM37 gene, integrated from 10 sources (see all 41):
(articles sorted by number of sources associating them with TRIM37)

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world of online information

Gene encoding a new RING-B-box-coiled-coil protein is mutated in mulibrey nanism. (PubMed id 10888877)^{1, 2, 3} Avela K.... Lehesjoki A.E. (Nat. Genet. 2000)
The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder. (PubMed id 11938494)^{1, 2, 9} Kallijarvi J....Lehesjoki A.E. (Am. J. Hum. Genet. 2002)
Novel mutations in the TRIM37 gene in Mulibrey Nanism. (PubMed id 15108285)^{1, 2, 9} Haemaelaeinen R.H....Lehesjoki A.E. (Hum. Mutat. 2004)
Wilms' tumor and novel TRIM37 mutations in an Australian patient with mulibrey nanism. (PubMed id 17100991)^{1, 2, 9} Haemaelaeinen R.H.... Lehesjoki A.-E. (Clin. Genet. 2006)
A novel splice site mutation in the TRIM37 gene causes mulibrey nanism in a Turkish family with phenotypic heterogeneity. (PubMed id 12754710)^{1, 2, 9} Jagiello P.... Gencik M. (Hum. Mutat. 2003)
TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase. (PubMed id 15885686)^{1, 2} Kallijaervi J.... Lehesjoki A.-E. (Exp. Cell Res. 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)^{1, 2} Nagase T.... Ohara O. (DNA Res. 1998)
Assignment of the mulibrey nanism gene to 17q by linkage and linkage-disequilibrium analysis. (PubMed id 9106536)^{1, 3} Avela K....Lehesjoki A.E. (Am. J. Hum. Genet. 1997)
Gynecological tumors in Mulibrey nanism and role for RING finger protein TRIM37 in the pathogenesis of ovarian fibrothecomas. (PubMed id 19329943)^{1, 9} Karlberg S....Butzow R. (Mod. Pathol. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4591	HGNC: 7523	AceView: TRIM37	Ensembl:ENSG00000108395	euGenes: HUgn4591
ECgene: TRIM37	Kegg: 4591	H-InvDB: TRIM37

(According to HUGE)
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HUGE: KIAA0898

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TRIM37	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TRIM37	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.ncbi.nlm.nih.gov/books/NBK1116/?term=TRIM37[genesymbol]

Intellectual Property for TRIM37 gene
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Patent Information for TRIM37 gene:
Search GeneIP for patents involving TRIM37

GeneCards and IP:
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TRIM37 Gene

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Tripartite Motif Containing 37

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