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Aliases for TRIM37 Gene

Aliases for TRIM37 Gene

  • Tripartite Motif Containing 37 2 3 5
  • RING-B-Box-Coiled-Coil Protein 2 3
  • Mulibrey Nanism Protein 3 4
  • POB1 3 4
  • MUL 3 4
  • Tripartite Motif-Containing Protein 37 4
  • E3 Ubiquitin-Protein Ligase TRIM37 3
  • Tripartite Motif-Containing 37 2
  • EC 6.3.2.- 4
  • KIAA0898 4
  • TEF3 3

External Ids for TRIM37 Gene

Previous HGNC Symbols for TRIM37 Gene

  • MUL

Previous GeneCards Identifiers for TRIM37 Gene

  • GC17M056903
  • GC17M059637
  • GC17M057401
  • GC17M057549
  • GC17M054430
  • GC17M054414
  • GC17M057059
  • GC17M052420

Summaries for TRIM37 Gene

Entrez Gene Summary for TRIM37 Gene

  • This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. [provided by RefSeq, Mar 2016]

GeneCards Summary for TRIM37 Gene

TRIM37 (Tripartite Motif Containing 37) is a Protein Coding gene. Diseases associated with TRIM37 include Mulibrey Nanism and Acid-Labile Subunit, Deficiency Of. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include protein homodimerization activity and ligase activity.

UniProtKB/Swiss-Prot for TRIM37 Gene

  • E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of Lys-119 of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724).

Gene Wiki entry for TRIM37 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM37 Gene

Genomics for TRIM37 Gene

Regulatory Elements for TRIM37 Gene

Enhancers for TRIM37 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F058657 1.9 FANTOM5 Ensembl ENCODE 37.4 +448.0 448011 2.2 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 SRSF1 TRIM37 RAD51C VEZF1 SMG8 SETP3 OR4D1 SPDYE22P ENSG00000264914 CCDC182
GH17F058665 1.6 FANTOM5 Ensembl ENCODE 33 +439.7 439665 4.0 PKNOX1 ATF1 SIN3A ZNF121 FOS ZNF548 KDM4B ZNF263 GTF2B NCOA1 TRIM37 RAD51C SRSF1 SMG8 TEX14 SUPT4H1 RNU1-108P ENSG00000266561
GH17F058389 1.7 FANTOM5 Ensembl ENCODE 29.3 +715.8 715832 2.5 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 RNF43 TRIM37 SUPT4H1 HSF5
GH17F059105 1.1 ENCODE 44.5 +0.3 303 2.8 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 TRIM37 RAD51C RPS6KB1 ENSG00000224738
GH17F058785 1.3 Ensembl ENCODE 37.4 +320.2 320193 1.5 PKNOX1 ATF1 ARNT SIN3A FEZF1 GATA2 FOS JUNB ZHX2 NCOA1 TRIM37 TEX14 PPM1E ENSG00000276601 GC17P058810
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM37 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM37 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001350038 321 3201 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for TRIM37 Gene

Chromosome:
17
Start:
58,982,638 bp from pter
End:
59,106,921 bp from pter
Size:
124,284 bases
Orientation:
Minus strand

Genomic View for TRIM37 Gene

Genes around TRIM37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM37 Gene

Proteins for TRIM37 Gene

  • Protein details for TRIM37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94972-TRI37_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM37
    Protein Accession:
    O94972
    Secondary Accessions:
    • A8K0V9
    • A8K8U4
    • A8MZ79
    • B4DGZ3
    • F8WEE6
    • Q7Z3E6
    • Q8IYF7
    • Q8WYF7

    Protein attributes for TRIM37 Gene

    Size:
    964 amino acids
    Molecular mass:
    107906 Da
    Quaternary structure:
    • Associates with the PRC2/EED-EZH2 complex.
    Miscellaneous:
    • Acts as a proto-oncogene via its ability to monoubiquinate Lys-119 of histone H2A (H2AK119Ub): overexpressed in a number of breast cancers and promotes transformation of cells by mediating silencing of tumor suppressor genes (PubMed:25470042).
    SequenceCaution:
    • Sequence=BAA74921.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM37 Gene

    Alternative splice isoforms for TRIM37 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM37 Gene

Post-translational modifications for TRIM37 Gene

Antibody Products

  • Abcam antibodies for TRIM37

No data available for DME Specific Peptides for TRIM37 Gene

Domains & Families for TRIM37 Gene

Gene Families for TRIM37 Gene

Graphical View of Domain Structure for InterPro Entry

O94972

UniProtKB/Swiss-Prot:

TRI37_HUMAN :
  • Contains 1 MATH domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Domain:
  • Contains 1 MATH domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM37: view

Function for TRIM37 Gene

Molecular function for TRIM37 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of Lys-119 of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724).
UniProtKB/Swiss-Prot Induction:
Overexpressed in a number of breast cancer cell lines.

Enzyme Numbers (IUBMB) for TRIM37 Gene

Gene Ontology (GO) - Molecular Function for TRIM37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0004842 ubiquitin-protein transferase activity IDA 15885686
GO:0005164 tumor necrosis factor receptor binding IPI 11279055
GO:0005515 protein binding IPI 11279055
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM37: view
genes like me logo Genes that share phenotypes with TRIM37: view

Human Phenotype Ontology for TRIM37 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for TRIM37 Gene

miRTarBase miRNAs that target TRIM37

Inhibitory RNA Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM37 Gene

Localization for TRIM37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM37 Gene

Cytoplasm, perinuclear region. Peroxisome. Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. {ECO:0000269 PubMed:15885686}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM37 gene
Compartment Confidence
peroxisome 5
cytosol 5
nucleus 4
extracellular 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRIM37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA,IDA 23769972
GO:0005777 peroxisome IEA,IDA 11938494
GO:0005829 cytosol IDA 11279055
GO:0016235 aggresome IDA 15885686
genes like me logo Genes that share ontologies with TRIM37: view

Pathways & Interactions for TRIM37 Gene

genes like me logo Genes that share pathways with TRIM37: view

UniProtKB/Swiss-Prot O94972-TRI37_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 25470042
GO:0006351 transcription, DNA-templated IEA --
GO:0016567 protein ubiquitination IEA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 11279055
GO:0035518 histone H2A monoubiquitination IDA 25470042
genes like me logo Genes that share ontologies with TRIM37: view

No data available for SIGNOR curated interactions for TRIM37 Gene

Transcripts for TRIM37 Gene

Unigene Clusters for TRIM37 Gene

Tripartite motif containing 37:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM37 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4:
SP5:
SP6:
SP7: - - - - - -
SP8: -
SP9:

ExUns: 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
SP1: -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -

Relevant External Links for TRIM37 Gene

GeneLoc Exon Structure for
TRIM37
ECgene alternative splicing isoforms for
TRIM37

Expression for TRIM37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM37 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.6).

Protein differential expression in normal tissues from HIPED for TRIM37 Gene

This gene is overexpressed in Adipocyte (38.6) and Testis (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM37 Gene



Protein tissue co-expression partners for TRIM37 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM37 Gene:

TRIM37

SOURCE GeneReport for Unigene cluster for TRIM37 Gene:

Hs.579079

mRNA Expression by UniProt/SwissProt for TRIM37 Gene:

O94972-TRI37_HUMAN
Tissue specificity: Ubiquitous (PubMed:10888877). Highly expressed in testis, while it is weakly expressed in other tissues (PubMed:16310976).
genes like me logo Genes that share expression patterns with TRIM37: view

Orthologs for TRIM37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM37 34 35
  • 99.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 97 (a)
OneToMany
-- 35
  • 77 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TRIM37 34 35
  • 92.72 (n)
cow
(Bos Taurus)
Mammalia TRIM37 34 35
  • 91.22 (n)
mouse
(Mus musculus)
Mammalia Trim37 34 16 35
  • 88.75 (n)
rat
(Rattus norvegicus)
Mammalia Trim37 34
  • 88.54 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIM37 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM37 34 35
  • 75.28 (n)
lizard
(Anolis carolinensis)
Reptilia TRIM37 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim37 34
  • 70.37 (n)
Str.3537 34
zebrafish
(Danio rerio)
Actinopterygii trim37 34 35
  • 63.24 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7142 35
  • 63 (a)
OneToOne
Species where no ortholog for TRIM37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM37 Gene

ENSEMBL:
Gene Tree for TRIM37 (if available)
TreeFam:
Gene Tree for TRIM37 (if available)

Paralogs for TRIM37 Gene

(1) SIMAP similar genes for TRIM37 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with TRIM37: view

No data available for Paralogs for TRIM37 Gene

Variants for TRIM37 Gene

Sequence variations from dbSNP and Humsavar for TRIM37 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs121908391 Mulibrey nanism (MUL) [MIM:253250], Pathogenic 59,084,045(-) GACTT(C/G)TAAGA intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs386834004 Mulibrey nanism (MUL) [MIM:253250], Likely pathogenic 59,088,345(-) ACAGC(C/T)TGATA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs386834009 Mulibrey nanism (MUL) [MIM:253250], Likely pathogenic 59,061,086(-) GCGAG(G/T)TTACT nc-transcript-variant, reference, missense
rs386833416 Pathogenic 59,028,460(-) GAATG(-/G)AACTC nc-transcript-variant, reference, frameshift-variant
rs386833999 Likely pathogenic 59,057,033(-) GAGAT(-/AGAT)GGTTC nc-transcript-variant, reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM37 Gene

Variant ID Type Subtype PubMed ID
nsv510719 CNV deletion 20534489
nsv514855 CNV loss 21397061
nsv828068 CNV loss 20364138
nsv828069 CNV loss 20364138
nsv833499 CNV loss 17160897
nsv9574 CNV loss 18304495
nsv962452 CNV deletion 23825009
nsv507849 OTHER sequence alteration 20534489
nsv1134660 CNV deletion 24896259
nsv1127585 CNV deletion 24896259
nsv1065063 CNV gain 25217958
esv3640901 CNV loss 21293372
esv3640900 CNV loss 21293372
esv3554606 CNV deletion 23714750
esv2758699 CNV gain 17122850
esv2675820 CNV deletion 23128226
esv2421884 CNV deletion 20811451
dgv3270n100 CNV gain 25217958

Variation tolerance for TRIM37 Gene

Residual Variation Intolerance Score: 6.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM37 Gene

Human Gene Mutation Database (HGMD)
TRIM37
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM37 Gene

Disorders for TRIM37 Gene

MalaCards: The human disease database

(10) MalaCards diseases for TRIM37 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mulibrey nanism
  • muscle-liver-brain-eye nanism
acid-labile subunit, deficiency of
  • acid-labile subunit deficiency
emphysematous cholecystitis
  • gaseous pericholecystitis
pontiac fever
purulent labyrinthitis
  • acute suppurative labyrinthitis
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TRI37_HUMAN
  • Mulibrey nanism (MUL) [MIM:253250]: An autosomal recessive growth disorder characterized by severe growth failure of prenatal onset, constrictive pericardium and progressive cardiomyopathy, facial dysmorphism, and failure of sexual maturation. Additional clinical features include hepatomegaly, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, hypoplasia of various endocrine glands, insulin resistance with type 2 diabetes, and an increased risk for Wilms tumor. {ECO:0000269 PubMed:10888877, ECO:0000269 PubMed:12754710, ECO:0000269 PubMed:15108285, ECO:0000269 PubMed:15885686, ECO:0000269 PubMed:17100991, ECO:0000269 PubMed:17551331, ECO:0000269 PubMed:21865362, ECO:0000269 PubMed:23385855}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TRIM37

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM37
genes like me logo Genes that share disorders with TRIM37: view

No data available for Genatlas for TRIM37 Gene

Publications for TRIM37 Gene

  1. A novel mutation in TRIM37 is associated with mulibrey nanism in a Turkish boy. (PMID: 17551331) DoA9anc T. … Tekin M. (Clin. Dysmorphol. 2007) 3 4 22 64
  2. Characterisation of the mulibrey nanism-associated TRIM37 gene: transcription initiation, promoter region and alternative splicing. (PMID: 16310976) HAomAolAoinen R.H. … Lehesjoki A.E. (Gene 2006) 3 4 22 64
  3. Wilms' tumor and novel TRIM37 mutations in an Australian patient with mulibrey nanism. (PMID: 17100991) Haemaelaeinen R.H. … Lehesjoki A.-E. (Clin. Genet. 2006) 3 4 22 64
  4. Novel mutations in the TRIM37 gene in Mulibrey Nanism. (PMID: 15108285) Haemaelaeinen R.H. … Lehesjoki A.E. (Hum. Mutat. 2004) 3 4 22 64
  5. A novel splice site mutation in the TRIM37 gene causes mulibrey nanism in a Turkish family with phenotypic heterogeneity. (PMID: 12754710) Jagiello P. … Gencik M. (Hum. Mutat. 2003) 3 4 22 64

Products for TRIM37 Gene

Sources for TRIM37 Gene

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