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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM37 Gene

protein-coding   GIFtS: 62
GCID: GC17M057059

Tripartite Motif Containing 37

(Previous name: tripartite motif-containing 37)
(Previous symbol: MUL)
Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tripartite Motif Containing 371 2     KIAA08983 5
MUL1 2 3 5     Tripartite Motif-Containing 371
RING-B-Box-Coiled-Coil Protein1 2     TEF32
Mulibrey Nanism Protein2 3     E3 Ubiquitin-Protein Ligase TRIM372
Tripartite Motif-Containing Protein 372 3     EC 6.3.2.-3
POB12 3     

External Ids:    HGNC: 75231   Entrez Gene: 45912   Ensembl: ENSG000001083957   OMIM: 6050735   UniProtKB: O949723   

Export aliases for TRIM37 gene to outside databases

Previous GC identifers: GC17M056903 GC17M059637 GC17M057401 GC17M057549 GC17M054430 GC17M054414 GC17M052420


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRIM37 Gene:
This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular
functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING
finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might
be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with
mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of
mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TRIM37 Gene: 
TRIM37 (tripartite motif containing 37) is a protein-coding gene. Diseases associated with TRIM37 include mulibrey nanism, and ovarian fibrothecoma, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Immune System. GO annotations related to this gene include protein homodimerization activity and ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot: TRI37_HUMAN, O94972
Function: E3 ubiquitin-protein ligase

Gene Wiki entry for TRIM37 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM37 gene promoter:
         Tal-1   p53   SREBP-1c   CUTL1   E47   SREBP-1b   SREBP-1a   Cart-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM37 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM37

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q

TRIM37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM37 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M057059:  view genomic region     (about GC identifiers)

Start:
57,059,999 bp from pter      End:
57,184,282 bp from pter
Size:
124,284 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRI37_HUMAN, O94972 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM37  
Size: 964 amino acids; 107906 Da
Subcellular location: Cytoplasm, perinuclear region. Peroxisome. Note=Found in vesicles of the peroxisome.
Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for
proteasomal degradation
Sequence caution: Sequence=BAA74921.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for TRIM37:
3LRQ (3D)    
Secondary accessions: Q7Z3E6 Q8IYF7 Q8WYF7
Alternative splicing: 2 isoforms:  O94972-1   O94972-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIM37: NX_O94972

Explore proteomics data for TRIM37 at MOPED 

Post-translational modifications:

  • UniProtKB: Auto-ubiquitinated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O94972

  • TRIM37 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRIM37 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001005207.1  NP_056109.1  

    ENSEMBL proteins: 
     ENSP00000464666   ENSP00000462778   ENSP00000376785   ENSP00000462340   ENSP00000262294  
     ENSP00000376784   ENSP00000462863   ENSP00000464590   ENSP00000464688   ENSP00000464263  
     ENSP00000365319  
    Reactome Protein details: O94972
    Human Recombinant Protein Products for TRIM37: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIM37 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0005777peroxisome IDA11938494
    GO:0005829cytosol IDA11279055
    GO:0016235aggresome IDA15885686

    TRIM37 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TRIM: Tripartite motif containing / Tripartite motif containing

    5/6 InterPro protein domains (see all 6):
     IPR003649 Bbox_C
     IPR008974 TRAF-like
     IPR002083 MATH
     IPR001841 Znf_RING
     IPR000315 Znf_B-box

    Graphical View of Domain Structure for InterPro Entry O94972

    ProtoNet protein and cluster: O94972

    4 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB002083 Meprin/TRAF-like MATH
    IPB003649 B-box


    UniProtKB/Swiss-Prot: TRI37_HUMAN, O94972
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 MATH domain
    Similarity: Contains 1 RING-type zinc finger


    TRIM37 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI37_HUMAN, O94972
    Function: E3 ubiquitin-protein ligase

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA15885686
    GO:0005164tumor necrosis factor receptor binding IPI11279055
    GO:0005515protein binding IPI11279055
    GO:0008270zinc ion binding IEA--
    GO:0031625ubiquitin protein ligase binding IPI11279055
         
    TRIM37 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRIM37:
     Increased S DNA content  S arrest 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRIM37 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM37 
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    SwitchGear 3'UTR luciferase reporter plasmidTRIM37 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRIM37 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for TRIM37
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    1         Kegg Pathway  (Kegg details for TRIM37):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: TRI37_HUMAN, O94972
    Pathway: Protein modification; protein ubiquitination


    TRIM37 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM37

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/59 Interacting proteins for TRIM37 (O949721, 2, 3 ENSP000002622944) via UniProtKB, MINT, STRING, and/or I2D (see all 59)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRC1O436631, 2, 3, ENSP000003777934EBI-741602,EBI-741137 MINT-67438 I2D: score=6 STRING: ENSP00000377793
    APTXQ7Z2E32, 3, ENSP000004008064MINT-2860941 MINT-2860960 I2D: score=3 STRING: ENSP00000400806
    APEX2Q9UBZ42, 3, ENSP000003641264MINT-66277 I2D: score=5 STRING: ENSP00000364126
    BYSLQ138952, 3, ENSP000002303404MINT-66930 I2D: score=5 STRING: ENSP00000230340
    FAM107AO959902, 3, ENSP000003542704MINT-66452 I2D: score=5 STRING: ENSP00000354270
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032088negative regulation of NF-kappaB transcription factor activity IDA11279055
    GO:0046600negative regulation of centriole replication IMP--
    GO:0051865protein autoubiquitination IDA15885686
    GO:0070842aggresome assembly IDA15885686

    TRIM37 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM37 (TRI37)

    Search CenterWatch for drugs/clinical trials and news about TRIM37 / TRI37

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRIM37 gene (2 alternative transcripts): 
    NM_001005207.2  NM_015294.3  

    Unigene Cluster for TRIM37:

    Tripartite motif containing 37
    Hs.579079  [show with all ESTs]
    Unigene Representative Sequence: NM_015294
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585287 ENST00000583945 ENST00000393066(uc002iwy.4) ENST00000577554
    ENST00000262294 ENST00000393065 ENST00000581468 ENST00000582852 ENST00000580973
    ENST00000580122 ENST00000580620 ENST00000583387 ENST00000584889 ENST00000376149(uc002iwz.4 uc002ixa.4 uc010woc.2)


    miRNA
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    Additional mRNA sequence: 

    AB020705.1 AF213365.1 AK022701.1 AK025648.1 AK289674.1 AK292459.1 AK294850.1 BC036012.1 
    BX537955.1 

    18 DOTS entries:

    DT.456338  DT.97843497  DT.91723801  DT.95252077  DT.120930631  DT.314049  DT.91723799  DT.100693863 
    DT.100794522  DT.91723787  DT.97843499  DT.120930369  DT.120930495  DT.86846390  DT.91723786  DT.91723788 
    DT.314344  DT.75106535 

    24/145 AceView cDNA sequences (see all 145):

    BM471820 CB163050 AL135214 NM_015294 AV715627 BI827062 AI699757 AI080375 
    AA411819 AL560678 AA875957 AI885776 CB135536 CR606792 BX537955 AI382965 
    AA099340 AI360278 AK025648 AI339566 BQ008995 BF511737 BX492275 CR621658 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM37 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
    SP1:                                      -           -     -                                               -                                                   
    SP2:                                                  -     -                                               -                                                   
    SP3:                          -           -           -     -                                                                                                   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
    SP1:                                      -                     
    SP2:                                      -     -               
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for TRIM37

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM37 expression in normal human tissues (normalized intensities)      TRIM37 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGAGACAT
    TRIM37 Expression
    About this image


    TRIM37 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord

    See TRIM37 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM37

    SOURCE GeneReport for Unigene cluster: Hs.579079

    UniProtKB/Swiss-Prot: TRI37_HUMAN, O94972
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including TRIM37: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TRIM37 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim371 , 5 tripartite motif-containing 371, 5 88.75(n)1
    92.92(a)1
      11 (51.93 cM)5
    687291  NM_197987.11  NP_932104.11 
     871270775 
    chicken
    (Gallus gallus)
    Aves TRIM371 tripartite motif containing 37 75.45(n)
    81.77(a)
      417628  NM_001006224.1  NP_001006224.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRIM376
    Uncharacterized protein
    76(a)
    1 ↔ 1
    GL343684.1(269862-322481)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.35372 Transcribed sequence with strong similarity to protein more 78.76(n)    AL853018.2 
    zebrafish
    (Danio rerio)
    Actinopterygii trim371 tripartite motif containing 37 64.29(n)
    69.84(a)
      324237  XM_003199359.1  XP_003199407.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0015441 AGAP001544-PA 42.63(n)
    31.46(a)
      4576818  XM_001238506.1  XP_001238507.1 


    ENSEMBL Gene Tree for TRIM37 (if available)
    TreeFam Gene Tree for TRIM37 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM37 gene
    1 SIMAP similar gene for TRIM37 using alignment to 10 protein entries:     TRI37_HUMAN (see all proteins):
    RAD18

    TRIM37 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2244 SNPs in TRIM37 are shown (see all 2244)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0602174
    Mulibrey nanism (MUL)4--see VAR_0602172 L P mis40--------
    VAR_0602204
    Mulibrey nanism (MUL)4--see VAR_0602202 G V mis40--------
    VAR_0602194
    Mulibrey nanism (MUL)4--see VAR_0602192 C S mis40--------
    rs607699051,2
    C--57063253(+) GAAAG-/AAGGACAT 1 -- int10--------
    rs711455101,2
    C--57068537(+) AAAAAA/-GAAAA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs588826311,2
    C--57069621(+) ATATA-/TAAATAT 1 -- int11Minor allele frequency- TA:0.00NA 2
    rs352220791,2
    C--57069684(+) TGTAA-/ATATATA 1 -- int10--------
    rs1128529541,2
    C,F--57070535(+) AGATGT/GGCCTT 1 -- int12Minor allele frequency- G:0.11CSA WA 119
    rs600938121,2
    C--57071160(+) AGGAT-/ATGTGGG 1 -- int10--------
    rs346270441,2
    C--57074169(+) TGTGT-/GTGTGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TRIM37 (57059999 - 57184282 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for TRIM37 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2421884CNV Deletion20811451
    esv2675820CNV Deletion23128226
    nsv507849CNV Insertion20534489
    nsv510719CNV Loss20534489
    nsv908644CNV Loss21882294
    nsv828069CNV Loss20364138
    dgv3237n71CNV Loss21882294
    nsv833499CNV Loss17160897
    dgv3236n71CNV Loss21882294
    nsv514855CNV Loss21397061


    Human Gene Mutation Database (HGMD): TRIM37
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM37
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM37

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605073   
    OMIM disorders: 253250  
    UniProtKB/Swiss-Prot: TRI37_HUMAN, O94972
  • Mulibrey nanism (MUL) [MIM:253250]: Autosomal recessive disorder that involves several tissues of
    mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth
    failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle
    hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia
    of various endocrine glands causing hormonal deficiency are common. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 9 diseases for TRIM37:    About MalaCards
    mulibrey nanism    ovarian fibrothecoma    growth disorders    peroxisome disorders
    human immunodeficiency virus infectious disease    neutropenia    hypotonia    wilms tumor
    insulin resistance

    3 diseases from the University of Copenhagen DISEASES database for TRIM37:
    Mulibrey nanism     Acquired immunodeficiency syndrome     Malaria

    TRIM37 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    8 Novoseek inferred disease relationships for TRIM37 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nanism mulibrey 99.3 26 15108285 (3), 11938494 (3), 19329943 (3), 16514549 (2) (see all 10)
    growth disorders 85.1 2 11938494 (1), 19329943 (1)
    growth failure 82.7 2 16514549 (1), 16310976 (1)
    peroxisomal disorders 81.7 3 11938494 (2), 15108285 (1)
    hepatomegaly 61.2 1 16310976 (1)
    heart diseases 41.9 1 16514549 (1)
    necrosis 0 1 17100991 (1)
    tumors 0 7 19329943 (2), 17100991 (1)


    Export disorders for TRIM37 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM37 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with TRIM37)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene encoding a new RING-B-box-coiled-coil protein is mutated in mulibrey nanism. (PubMed id 10888877)1, 2, 3 Avela K.... Lehesjoki A.E. (2000)
    2. The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder. (PubMed id 11938494)1, 2, 9 Kallijarvi J....Lehesjoki A.E. (2002)
    3. Novel mutations in the TRIM37 gene in Mulibrey Nanism. (PubMed id 15108285)1, 2, 9 Hamalainen R.H....Lehesjoki A.E. (2004)
    4. Wilms' tumor and novel TRIM37 mutations in an Australian patient with mulibrey nanism. (PubMed id 17100991)1, 2, 9 Haemaelaeinen R.H.... Lehesjoki A.-E. (2006)
    5. A novel splice site mutation in the TRIM37 gene causes mulibrey nanism in a Turkish family with phenotypic heterogeneity. (PubMed id 12754710)1, 2, 9 Jagiello P.... Gencik M. (2003)
    6. TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase. (PubMed id 15885686)1, 2 Kallijarvi J....Lehesjoki A.E. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
    9. Assignment of the mulibrey nanism gene to 17q by linkage and linkage-disequilibrium analysis. (PubMed id 9106536)1, 3 Avela K....Lehesjoki A.E. (1997)
    10. Gynecological tumors in Mulibrey nanism and role for RING finger protein TRIM37 in the pathogenesis of ovarian fibrothecomas. (PubMed id 19329943)1, 9 Karlberg S....Butzow R. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4591 HGNC: 7523 AceView: TRIM37 Ensembl:ENSG00000108395 euGenes: HUgn4591
    ECgene: TRIM37 Kegg: 4591 H-InvDB: TRIM37

    (According to HUGE)
    About This Section
    HUGE: KIAA0898

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM37 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRIM37 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TRIM37

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRIM37 gene:
    Search GeneIP for patents involving TRIM37

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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