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Aliases for TRIM36 Gene

Aliases for TRIM36 Gene

  • Tripartite Motif Containing 36 2 3 5
  • Zinc-Binding Protein Rbcc728 2 3 4
  • RING Finger Protein 98 2 3 4
  • RING-Type E3 Ubiquitin Transferase TRIM36 3 4
  • Tripartite Motif-Containing Protein 36 3 4
  • Tripartite Motif Protein 36 2 3
  • RBCC728 3 4
  • RNF98 3 4
  • E3 Ubiquitin-Protein Ligase TRIM36 3
  • Tripartite Motif-Containing 36 2
  • EC 4
  • HAPRIN 3
  • ANPH 3

External Ids for TRIM36 Gene

Previous GeneCards Identifiers for TRIM36 Gene

  • GC05M114064
  • GC05M114863
  • GC05M114491
  • GC05M114536
  • GC05M114488
  • GC05M114460
  • GC05M109642

Summaries for TRIM36 Gene

Entrez Gene Summary for TRIM36 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM36 Gene

TRIM36 (Tripartite Motif Containing 36) is a Protein Coding gene. Diseases associated with TRIM36 include Anencephaly and Endometriosis Of Ovary. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is TRIM46.

UniProtKB/Swiss-Prot for TRIM36 Gene

  • E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization.

Additional gene information for TRIM36 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM36 Gene

Genomics for TRIM36 Gene

GeneHancer (GH) Regulatory Elements for TRIM36 Gene

Promoters and enhancers for TRIM36 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I115169 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 555.3 +10.3 10302 2.5 PKNOX1 CLOCK ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF213 TRIM36 CCDC112 TRIM36-IT1
GH05I115180 Promoter 1.6 EPDnew Ensembl 550.8 +0.3 345 0.4 SUZ12 MAX BMI1 ZNF324 ZNF335 ZNF213 POLR2A PATZ1 ZNF600 ZBTB20 TRIM36 TRIM36-IT1
GH05I115181 Promoter 1.1 EPDnew 557.4 0.0 -47 0.1 SUZ12 ZNF449 MAX BMI1 ZNF324 ZNF335 POLR2A PATZ1 ZNF600 ZBTB20 TRIM36 ENSG00000249791
GH05I115149 Promoter 0.5 EPDnew 550.3 +30.9 30922 0.1 TRIM36-IT1 TRIM36 ENSG00000250242
GH05I115208 Enhancer 0.9 Ensembl ENCODE 11.1 -28.9 -28854 1.2 PKNOX1 BACH1 BMI1 IRF4 RELA POLR2A ATF7 ETV6 BCLAF1 IKZF2 TRIM36 PGGT1B GC05M115205 ENSG00000271797
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIM36 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRIM36 Gene

Genomic Locations for TRIM36 Gene
55,785 bases
Minus strand

Genomic View for TRIM36 Gene

Genes around TRIM36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM36 Gene

Proteins for TRIM36 Gene

  • Protein details for TRIM36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase TRIM36
    Protein Accession:
    Secondary Accessions:
    • A1L3Z1
    • A6NDD0
    • B7Z3V4
    • B7ZAV7
    • E9PFI8
    • Q0P5Z9

    Protein attributes for TRIM36 Gene

    728 amino acids
    Molecular mass:
    83013 Da
    Quaternary structure:
    • Interacts with CENPH.

    Alternative splice isoforms for TRIM36 Gene


neXtProt entry for TRIM36 Gene

Post-translational modifications for TRIM36 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRIM36 Gene

Domains & Families for TRIM36 Gene

Suggested Antigen Peptide Sequences for TRIM36 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM36: view

Function for TRIM36 Gene

Molecular function for TRIM36 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization.

Enzyme Numbers (IUBMB) for TRIM36 Gene

Phenotypes From GWAS Catalog for TRIM36 Gene

Gene Ontology (GO) - Molecular Function for TRIM36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0043014 alpha-tubulin binding ISS --
genes like me logo Genes that share ontologies with TRIM36: view
genes like me logo Genes that share phenotypes with TRIM36: view

Human Phenotype Ontology for TRIM36 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM36 Gene

Localization for TRIM36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM36 Gene

Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton. Note=Found in the acrosomal region of elongated spermatids and mature sperm. {ECO:0000250 UniProtKB:Q80WG7}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM36 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 4
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IDA,IEA 28087737
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TRIM36: view

Pathways & Interactions for TRIM36 Gene

genes like me logo Genes that share pathways with TRIM36: view

Gene Ontology (GO) - Biological Process for TRIM36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0000281 mitotic cytokinesis IMP 28087737
GO:0007051 spindle organization IMP 28087737
GO:0007340 acrosome reaction IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with TRIM36: view

No data available for SIGNOR curated interactions for TRIM36 Gene

Drugs & Compounds for TRIM36 Gene

(1) Drugs for TRIM36 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TRIM36: view

Transcripts for TRIM36 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM36 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: -
SP7: -
SP9: -

Relevant External Links for TRIM36 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM36 Gene

This gene is overexpressed in Testis (x15.8).

Protein differential expression in normal tissues from HIPED for TRIM36 Gene

This gene is overexpressed in Testis (30.8) and Ovary (21.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM36 Gene

Protein tissue co-expression partners for TRIM36 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM36 Gene:


SOURCE GeneReport for Unigene cluster for TRIM36 Gene:


mRNA Expression by UniProt/SwissProt for TRIM36 Gene:

Tissue specificity: Highly expressed in testis, prostate and brain (PubMed:15145053). Weakly expressed in kidney, lung and heart (PubMed:15145053). Expressed in fetal tissues (PubMed:28087737).

Evidence on tissue expression from TISSUES for TRIM36 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with TRIM36: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM36 Gene

Orthologs for TRIM36 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM36 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM36 33 34
  • 99.31 (n)
(Canis familiaris)
Mammalia TRIM36 33 34
  • 89.65 (n)
(Bos Taurus)
Mammalia TRIM36 33 34
  • 89.38 (n)
(Rattus norvegicus)
Mammalia Trim36 33
  • 87.32 (n)
(Monodelphis domestica)
Mammalia TRIM36 34
  • 87 (a)
(Mus musculus)
Mammalia Trim36 33 16 34
  • 86.58 (n)
(Ornithorhynchus anatinus)
Mammalia TRIM36 34
  • 72 (a)
(Gallus gallus)
Aves TRIM36 33 34
  • 73.02 (n)
(Anolis carolinensis)
Reptilia TRIM36 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trim36 33
  • 69.24 (n)
Str.16710 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6926 33
(Danio rerio)
Actinopterygii trim36 33 34
  • 60.93 (n)
Dr.28446 33
fruit fly
(Drosophila melanogaster)
Insecta Trim9 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea trim-9 34
  • 19 (a)
Species where no ortholog for TRIM36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM36 Gene

Gene Tree for TRIM36 (if available)
Gene Tree for TRIM36 (if available)

Paralogs for TRIM36 Gene

Paralogs for TRIM36 Gene

(3) SIMAP similar genes for TRIM36 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM36: view

Variants for TRIM36 Gene

Sequence variations from dbSNP and Humsavar for TRIM36 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs773607884 pathogenic, Anencephalus 115,133,872(-) G/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
VAR_079581 Anencephaly (ANPH) [MIM:206500] p.Asp518Asn
rs1000010725 -- 115,138,146(-) C/G genic_downstream_transcript_variant, intron_variant
rs1000028017 -- 115,171,772(-) T/C genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000099275 -- 115,181,846(-) TTTTTT/TTTTTTT upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM36 Gene

Variant ID Type Subtype PubMed ID
nsv462398 CNV loss 19166990
nsv471994 CNV novel sequence insertion 20440878
nsv599476 CNV loss 21841781
nsv599477 CNV gain 21841781
nsv830453 CNV gain 17160897
nsv830454 CNV gain+loss 17160897

Variation tolerance for TRIM36 Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM36 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM36 Gene

Disorders for TRIM36 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRIM36 Gene - From: HGMD, OMIM, ClinVar, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • anph
endometriosis of ovary
  • ovarian endometriosis
- elite association - COSMIC cancer census association via MalaCards


  • Anencephaly (ANPH) [MIM:206500]: An extreme form of neural tube defect resulting in the absence of brain tissues, and death in utero or perinatally. Infants are born with intact spinal cords, cerebellums, and brainstems, but lack formation of neural structures above this level. The skull is only partially formed. ANPH inheritance is autosomal recessive. {ECO:0000269 PubMed:28087737}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TRIM36

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TRIM36: view

No data available for Genatlas for TRIM36 Gene

Publications for TRIM36 Gene

  1. Cloning and characterisation of the RBCC728/TRIM36 zinc-binding protein from the tumor suppressor gene region at chromosome 5q22.3. (PMID: 15145053) Balint I … Kovacs G (Gene 2004) 3 4 22 58
  2. A homozygous mutation in TRIM36 causes autosomal recessive anencephaly in an Indian family. (PMID: 28087737) Singh N … Kumar A (Human molecular genetics 2017) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Identification of human HAPRIN potentially involved in the acrosome reaction. (PMID: 15955891) Kitamura K … Tanaka H (Journal of andrology 2005) 3 22 58
  5. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A … Ballabio A (The EMBO journal 2001) 2 3 58

Products for TRIM36 Gene

Sources for TRIM36 Gene

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