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Aliases for TRIM36 Gene

Aliases for TRIM36 Gene

  • Tripartite Motif Containing 36 2 3
  • Zinc-Binding Protein Rbcc728 2 3 4
  • RING Finger Protein 98 2 3 4
  • RBCC728 3 4 6
  • Tripartite Motif-Containing Protein 36 3 4
  • Tripartite Motif-Containing 36 2 3
  • Tripartite Motif Protein 36 2 3
  • RNF98 3 4
  • E3 Ubiquitin-Protein Ligase TRIM36 3
  • EC 6.3.2.- 4
  • HAPRIN 3

External Ids for TRIM36 Gene

Previous GeneCards Identifiers for TRIM36 Gene

  • GC05M114064
  • GC05M114863
  • GC05M114491
  • GC05M114536
  • GC05M114488
  • GC05M114460
  • GC05M109642

Summaries for TRIM36 Gene

Entrez Gene Summary for TRIM36 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM36 Gene

TRIM36 (Tripartite Motif Containing 36) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is MID1.

UniProtKB/Swiss-Prot for TRIM36 Gene

  • E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM36 Gene

Genomics for TRIM36 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIM36 Gene

Start:
115,124,762 bp from pter
End:
115,180,546 bp from pter
Size:
55,785 bases
Orientation:
Minus strand

Genomic View for TRIM36 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM36 Gene

No data available for Regulatory Elements for TRIM36 Gene

Proteins for TRIM36 Gene

  • Protein details for TRIM36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ86-TRI36_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM36
    Protein Accession:
    Q9NQ86
    Secondary Accessions:
    • A1L3Z1
    • A6NDD0
    • B7Z3V4
    • B7ZAV7
    • E9PFI8
    • Q0P5Z9

    Protein attributes for TRIM36 Gene

    Size:
    728 amino acids
    Molecular mass:
    83013 Da
    Quaternary structure:
    • Interacts with CENPH.

    Alternative splice isoforms for TRIM36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM36 Gene

Proteomics data for TRIM36 Gene at MOPED

Post-translational modifications for TRIM36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM36 Gene

Antibody Products

No data available for DME Specific Peptides for TRIM36 Gene

Domains for TRIM36 Gene

Gene Families for TRIM36 Gene

HGNC:
  • FN3 :Fibronectin type III domain containing
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Suggested Antigen Peptide Sequences for TRIM36 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQ86

UniProtKB/Swiss-Prot:

TRI36_HUMAN :
  • Q9NQ86
Domain:
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 COS domain.
  • Contains 1 fibronectin type-III domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 2 B box-type zinc fingers.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM36: view

Function for TRIM36 Gene

Molecular function for TRIM36 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization (By similarity).

Enzyme Numbers (IUBMB) for TRIM36 Gene

Gene Ontology (GO) - Molecular Function for TRIM36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM36: view

Phenotypes for TRIM36 Gene

GenomeRNAi human phenotypes for TRIM36:
genes like me logo Genes that share phenotypes with TRIM36: view

Animal Model Products

miRNA for TRIM36 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM36

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIM36 Gene

Localization for TRIM36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM36 Gene

Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton. Note=Found in the acrosomal region of elongated spermatids and mature sperm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM36 Gene COMPARTMENTS Subcellular localization image for TRIM36 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005622 intracellular --
GO:0005856 cytoskeleton IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TRIM36: view

Pathways for TRIM36 Gene

genes like me logo Genes that share pathways with TRIM36: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TRIM36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007340 acrosome reaction IEA --
GO:0016567 protein ubiquitination IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with TRIM36: view

Compounds for TRIM36 Gene

(1) Novoseek inferred chemical compound relationships for TRIM36 Gene

Compound -log(P) Hits PubMed IDs
zinc 44.7 1
genes like me logo Genes that share compounds with TRIM36: view

Transcripts for TRIM36 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM36

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM36 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: -
SP7: -
SP8:
SP9: -
SP10:

Relevant External Links for TRIM36 Gene

GeneLoc Exon Structure for
TRIM36
ECgene alternative splicing isoforms for
TRIM36

Expression for TRIM36 Gene

mRNA expression in normal human tissues for TRIM36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM36 Gene

This gene is overexpressed in Testis (15.8).

Protein differential expression in normal tissues for TRIM36 Gene

This gene is overexpressed in Testis (30.8) and Ovary (21.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRIM36 Gene

SOURCE GeneReport for Unigene cluster for TRIM36 Gene Hs.519514

mRNA Expression by UniProt/SwissProt for TRIM36 Gene

Q9NQ86-TRI36_HUMAN
Tissue specificity: Highly expressed in testis, prostate and brain. Weakly expressed in kidney, lung and heart.
genes like me logo Genes that share expressions with TRIM36: view

Expression partners for TRIM36 Gene

In Situ Assay Products

Orthologs for TRIM36 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM36 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIM36 35
  • 89.38 (n)
  • 94.92 (a)
TRIM36 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM36 35
  • 89.65 (n)
  • 95.47 (a)
TRIM36 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim36 35
  • 86.58 (n)
  • 92.58 (a)
Trim36 16
Trim36 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIM36 35
  • 99.31 (n)
  • 99.18 (a)
TRIM36 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim36 35
  • 87.32 (n)
  • 92.86 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIM36 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM36 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM36 35
  • 73.02 (n)
  • 74.01 (a)
TRIM36 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM36 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16710 35
trim36 35
  • 69.24 (n)
  • 69.66 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6926 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28446 35
trim36 35
  • 60.93 (n)
  • 64.56 (a)
trim36 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Trim9 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trim-9 36
  • 19 (a)
OneToMany
Species with no ortholog for TRIM36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM36 Gene

ENSEMBL:
Gene Tree for TRIM36 (if available)
TreeFam:
Gene Tree for TRIM36 (if available)

Paralogs for TRIM36 Gene

Selected SIMAP similar genes for TRIM36 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM36: view

Variants for TRIM36 Gene

Sequence variations from dbSNP and Humsavar for TRIM36 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs973 -- 115,168,892(-) TGGAA(A/G)TGATT intron-variant
rs192362 -- 115,158,345(+) AAAAA(A/T)TTTCA intron-variant
rs265403 -- 115,154,622(-) agcta(A/T)gaagg intron-variant
rs265404 -- 115,162,696(+) TGAAG(A/T)TCTAC intron-variant
rs265405 -- 115,175,788(+) ACATA(C/T)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM36 Gene

Variant ID Type Subtype PubMed ID
nsv882729 CNV Gain 21882294
nsv830453 CNV Gain 17160897
nsv462398 CNV Loss 19166990
nsv830454 CNV Gain+Loss 17160897
esv272655 CNV Insertion 20981092

Relevant External Links for TRIM36 Gene

HapMap Linkage Disequilibrium report
TRIM36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM36 Gene

Disorders for TRIM36 Gene

Relevant External Links for TRIM36

Genetic Association Database (GAD)
TRIM36
Human Genome Epidemiology (HuGE) Navigator
TRIM36

No disorders were found for TRIM36 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TRIM36 Gene

Publications for TRIM36 Gene

  1. Cloning and characterisation of the RBCC728/TRIM36 zinc-binding protein from the tumor suppressor gene region at chromosome 5q22.3. (PMID: 15145053) Balint I. … Kovacs G. (Gene 2004) 3 4 23
  2. Identification of human HAPRIN potentially involved in the acrosome reaction. (PMID: 15955891) Kitamura K. … Tanaka H. (J. Androl. 2005) 3 23
  3. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for TRIM36 Gene

Sources for TRIM36 Gene

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