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Aliases for TRIM36 Gene

Aliases for TRIM36 Gene

  • Tripartite Motif Containing 36 2 3 5
  • Zinc-Binding Protein Rbcc728 2 3 4
  • RING Finger Protein 98 2 3 4
  • RING-Type E3 Ubiquitin Transferase TRIM36 3 4
  • Tripartite Motif-Containing Protein 36 3 4
  • Tripartite Motif Protein 36 2 3
  • RBCC728 3 4
  • RNF98 3 4
  • E3 Ubiquitin-Protein Ligase TRIM36 3
  • Tripartite Motif-Containing 36 2
  • EC 2.3.2.27 4
  • HAPRIN 3

External Ids for TRIM36 Gene

Previous GeneCards Identifiers for TRIM36 Gene

  • GC05M114064
  • GC05M114863
  • GC05M114491
  • GC05M114536
  • GC05M114488
  • GC05M114460
  • GC05M109642

Summaries for TRIM36 Gene

Entrez Gene Summary for TRIM36 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM36 Gene

TRIM36 (Tripartite Motif Containing 36) is a Protein Coding gene. Diseases associated with TRIM36 include Anencephaly. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is TRIM46.

UniProtKB/Swiss-Prot for TRIM36 Gene

  • E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM36 Gene

Genomics for TRIM36 Gene

Regulatory Elements for TRIM36 Gene

Enhancers for TRIM36 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G115208 1.1 Ensembl ENCODE 11.1 -28.9 -28855 1.2 PKNOX1 TBL1XR1 BACH1 SIN3A BMI1 RELA ARID3A EED ETV6 RELB TRIM36 PGGT1B GC05M115205 ENSG00000271797
GH05G115169 1.4 FANTOM5 ENCODE 5.3 +10.3 10262 2.4 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 TRIM36 CCDC112 TRIM36-IT1
GH05G115348 1.1 Ensembl ENCODE 5.4 -169.0 -169028 1.8 FOXA2 RAD21 YY1 FOS IKZF2 USF2 CEBPB RAD51 CEBPA IKZF1 TRIM36 LOC105379130 LOC105379129
GH05G115242 0.5 ENCODE 10.4 -62.8 -62764 1.6 JUND ARID3A JUNB HNF4A TBX21 TRIM36 LOC101927100 TICAM2 TMED7-TICAM2 ENSG00000271797 GC05M115205
GH05G115351 1 Ensembl ENCODE 4.4 -171.2 -171155 0.6 JUN MAFG EBF1 EP300 FOSL1 MAFF JUND ZNF316 ATF3 NFE2 TRIM36 LOC105379130 LOC105379129
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM36 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM36 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000185505 346 401 SUZ12 TEAD4 MAX RBBP5 BMI1 ZNF324 POLR2A PATZ1 ZNF600 ZBTB20

Genomic Location for TRIM36 Gene

Chromosome:
5
Start:
115,124,762 bp from pter
End:
115,180,546 bp from pter
Size:
55,785 bases
Orientation:
Minus strand

Genomic View for TRIM36 Gene

Genes around TRIM36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM36 Gene

Proteins for TRIM36 Gene

  • Protein details for TRIM36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ86-TRI36_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM36
    Protein Accession:
    Q9NQ86
    Secondary Accessions:
    • A1L3Z1
    • A6NDD0
    • B7Z3V4
    • B7ZAV7
    • E9PFI8
    • Q0P5Z9

    Protein attributes for TRIM36 Gene

    Size:
    728 amino acids
    Molecular mass:
    83013 Da
    Quaternary structure:
    • Interacts with CENPH.

    Alternative splice isoforms for TRIM36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM36 Gene

Post-translational modifications for TRIM36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM36 Gene

Domains & Families for TRIM36 Gene

Suggested Antigen Peptide Sequences for TRIM36 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQ86

UniProtKB/Swiss-Prot:

TRI36_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM36: view

Function for TRIM36 Gene

Molecular function for TRIM36 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization.

Enzyme Numbers (IUBMB) for TRIM36 Gene

Gene Ontology (GO) - Molecular Function for TRIM36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM36: view
genes like me logo Genes that share phenotypes with TRIM36: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM36 Gene

Localization for TRIM36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM36 Gene

Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton. Note=Found in the acrosomal region of elongated spermatids and mature sperm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM36 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 4
nucleus 3

Gene Ontology (GO) - Cellular Components for TRIM36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TRIM36: view

Pathways & Interactions for TRIM36 Gene

genes like me logo Genes that share pathways with TRIM36: view

Gene Ontology (GO) - Biological Process for TRIM36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0007340 acrosome reaction IEA --
GO:0016567 protein ubiquitination IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with TRIM36: view

No data available for SIGNOR curated interactions for TRIM36 Gene

Drugs & Compounds for TRIM36 Gene

(1) Drugs for TRIM36 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TRIM36: view

Transcripts for TRIM36 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM36 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: -
SP7: -
SP8:
SP9: -
SP10:

Relevant External Links for TRIM36 Gene

GeneLoc Exon Structure for
TRIM36
ECgene alternative splicing isoforms for
TRIM36

Expression for TRIM36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM36 Gene

This gene is overexpressed in Testis (x15.8).

Protein differential expression in normal tissues from HIPED for TRIM36 Gene

This gene is overexpressed in Testis (30.8) and Ovary (21.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM36 Gene



Protein tissue co-expression partners for TRIM36 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM36 Gene:

TRIM36

SOURCE GeneReport for Unigene cluster for TRIM36 Gene:

Hs.519514

mRNA Expression by UniProt/SwissProt for TRIM36 Gene:

Q9NQ86-TRI36_HUMAN
Tissue specificity: Highly expressed in testis, prostate and brain. Weakly expressed in kidney, lung and heart.

Evidence on tissue expression from TISSUES for TRIM36 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with TRIM36: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM36 Gene

Orthologs for TRIM36 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM36 34 35
  • 99.31 (n)
dog
(Canis familiaris)
Mammalia TRIM36 34 35
  • 89.65 (n)
cow
(Bos Taurus)
Mammalia TRIM36 34 35
  • 89.38 (n)
rat
(Rattus norvegicus)
Mammalia Trim36 34
  • 87.32 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIM36 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim36 34 16 35
  • 86.58 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM36 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM36 34 35
  • 73.02 (n)
lizard
(Anolis carolinensis)
Reptilia TRIM36 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim36 34
  • 69.24 (n)
Str.16710 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6926 34
zebrafish
(Danio rerio)
Actinopterygii trim36 34 35
  • 60.93 (n)
Dr.28446 34
fruit fly
(Drosophila melanogaster)
Insecta Trim9 35
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trim-9 35
  • 19 (a)
OneToMany
Species where no ortholog for TRIM36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM36 Gene

ENSEMBL:
Gene Tree for TRIM36 (if available)
TreeFam:
Gene Tree for TRIM36 (if available)

Paralogs for TRIM36 Gene

(3) SIMAP similar genes for TRIM36 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM36: view

Variants for TRIM36 Gene

Sequence variations from dbSNP and Humsavar for TRIM36 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000010725 -- 115,138,146(+) ACAGA(C/G)TGGAG intron-variant
rs1000028017 -- 115,171,772(+) AAACA(C/T)GATGT intron-variant, upstream-variant-2KB
rs1000099275 -- 115,181,845(+) GAACA(-/T)TTTTT upstream-variant-2KB
rs1000132458 -- 115,166,740(+) CTGGA(C/T)TTAGG intron-variant
rs1000209308 -- 115,162,750(+) ATGCT(C/G)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM36 Gene

Variant ID Type Subtype PubMed ID
nsv462398 CNV loss 19166990
nsv471994 CNV novel sequence insertion 20440878
nsv599476 CNV loss 21841781
nsv599477 CNV gain 21841781
nsv830453 CNV gain 17160897
nsv830454 CNV gain+loss 17160897

Variation tolerance for TRIM36 Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM36 Gene

Disorders for TRIM36 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM36 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
anencephaly
  • absence of a large part of the brain and the skull
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIM36

Genetic Association Database (GAD)
TRIM36
Human Genome Epidemiology (HuGE) Navigator
TRIM36
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM36
genes like me logo Genes that share disorders with TRIM36: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM36 Gene

Publications for TRIM36 Gene

  1. Cloning and characterisation of the RBCC728/TRIM36 zinc-binding protein from the tumor suppressor gene region at chromosome 5q22.3. (PMID: 15145053) Balint I. … Kovacs G. (Gene 2004) 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Identification of human HAPRIN potentially involved in the acrosome reaction. (PMID: 15955891) Kitamura K. … Tanaka H. (J. Androl. 2005) 3 22 64
  4. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3 64
  5. A homozygous mutation in TRIM36 causes autosomal recessive anencephaly in an Indian family. (PMID: 28087737) Singh N. … Kumar A. (Hum. Mol. Genet. 2017) 3 64

Products for TRIM36 Gene

Sources for TRIM36 Gene

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