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Aliases for TRIM36 Gene

Aliases for TRIM36 Gene

  • Tripartite Motif Containing 36 2 3
  • Zinc-Binding Protein Rbcc728 2 3 4
  • RING Finger Protein 98 2 3 4
  • Tripartite Motif-Containing Protein 36 3 4
  • Tripartite Motif-Containing 36 2 3
  • Tripartite Motif Protein 36 2 3
  • RBCC728 3 4
  • RNF98 3 4
  • EC 6.3.2.- 4
  • HAPRIN 3

External Ids for TRIM36 Gene

Previous GeneCards Identifiers for TRIM36 Gene

  • GC05M114064
  • GC05M114863
  • GC05M114491
  • GC05M114536
  • GC05M114488
  • GC05M114460
  • GC05M109642

Summaries for TRIM36 Gene

Entrez Gene Summary for TRIM36 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM36 Gene

TRIM36 (Tripartite Motif Containing 36) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is MID1.

UniProtKB/Swiss-Prot for TRIM36 Gene

  • E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM36 Gene

Genomics for TRIM36 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIM36 Gene

Chromosome:
5
Start:
115,124,762 bp from pter
End:
115,180,546 bp from pter
Size:
55,785 bases
Orientation:
Minus strand

Genomic View for TRIM36 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM36 Gene

No data available for Regulatory Elements for TRIM36 Gene

Proteins for TRIM36 Gene

  • Protein details for TRIM36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ86-TRI36_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM36
    Protein Accession:
    Q9NQ86
    Secondary Accessions:
    • A1L3Z1
    • A6NDD0
    • B7Z3V4
    • B7ZAV7
    • E9PFI8
    • Q0P5Z9

    Protein attributes for TRIM36 Gene

    Size:
    728 amino acids
    Molecular mass:
    83013 Da
    Quaternary structure:
    • Interacts with CENPH.

    Alternative splice isoforms for TRIM36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM36 Gene

Proteomics data for TRIM36 Gene at MOPED

Post-translational modifications for TRIM36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for TRIM36 Gene

Domains & Families for TRIM36 Gene

Suggested Antigen Peptide Sequences for TRIM36 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQ86

UniProtKB/Swiss-Prot:

TRI36_HUMAN :
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 2 B box-type zinc fingers.
Domain:
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 COS domain.
  • Contains 1 fibronectin type-III domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 2 B box-type zinc fingers.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM36: view

Function for TRIM36 Gene

Molecular function for TRIM36 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization (By similarity).

Enzyme Numbers (IUBMB) for TRIM36 Gene

Gene Ontology (GO) - Molecular Function for TRIM36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM36: view
genes like me logo Genes that share phenotypes with TRIM36: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM36

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM36 Gene

Localization for TRIM36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM36 Gene

Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton. Note=Found in the acrosomal region of elongated spermatids and mature sperm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM36 Gene COMPARTMENTS Subcellular localization image for TRIM36 gene
Compartment Confidence
extracellular 5
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for TRIM36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005622 intracellular --
GO:0005856 cytoskeleton IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TRIM36: view

Pathways & Interactions for TRIM36 Gene

genes like me logo Genes that share pathways with TRIM36: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TRIM36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007340 acrosome reaction IEA --
GO:0016567 protein ubiquitination IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with TRIM36: view

No data available for SIGNOR curated interactions for TRIM36 Gene

Drugs & Compounds for TRIM36 Gene

(1) Drugs for TRIM36 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
genes like me logo Genes that share compounds with TRIM36: view

Transcripts for TRIM36 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM36

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM36 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: -
SP7: -
SP8:
SP9: -
SP10:

Relevant External Links for TRIM36 Gene

GeneLoc Exon Structure for
TRIM36
ECgene alternative splicing isoforms for
TRIM36

Expression for TRIM36 Gene

mRNA expression in normal human tissues for TRIM36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM36 Gene

This gene is overexpressed in Testis (x15.8).

Protein differential expression in normal tissues from HIPED for TRIM36 Gene

This gene is overexpressed in Testis (30.8) and Ovary (21.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TRIM36 Gene



SOURCE GeneReport for Unigene cluster for TRIM36 Gene Hs.519514

mRNA Expression by UniProt/SwissProt for TRIM36 Gene

Q9NQ86-TRI36_HUMAN
Tissue specificity: Highly expressed in testis, prostate and brain. Weakly expressed in kidney, lung and heart.
genes like me logo Genes that share expression patterns with TRIM36: view

Protein tissue co-expression partners for TRIM36 Gene

Primer Products

In Situ Assay Products

Orthologs for TRIM36 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM36 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIM36 35
  • 89.38 (n)
  • 94.92 (a)
TRIM36 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM36 35
  • 89.65 (n)
  • 95.47 (a)
TRIM36 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim36 35
  • 86.58 (n)
  • 92.58 (a)
Trim36 16
Trim36 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIM36 35
  • 99.31 (n)
  • 99.18 (a)
TRIM36 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim36 35
  • 87.32 (n)
  • 92.86 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIM36 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM36 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM36 35
  • 73.02 (n)
  • 74.01 (a)
TRIM36 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM36 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16710 35
trim36 35
  • 69.24 (n)
  • 69.66 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6926 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28446 35
trim36 35
  • 60.93 (n)
  • 64.56 (a)
trim36 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Trim9 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trim-9 36
  • 19 (a)
OneToMany
Species with no ortholog for TRIM36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM36 Gene

ENSEMBL:
Gene Tree for TRIM36 (if available)
TreeFam:
Gene Tree for TRIM36 (if available)

Paralogs for TRIM36 Gene

(3) SIMAP similar genes for TRIM36 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM36: view

Variants for TRIM36 Gene

Sequence variations from dbSNP and Humsavar for TRIM36 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_020490 -
VAR_023197 -
VAR_023198 -
VAR_057221 -

Structural Variations from Database of Genomic Variants (DGV) for TRIM36 Gene

Variant ID Type Subtype PubMed ID
nsv882729 CNV Gain 21882294
nsv830453 CNV Gain 17160897
nsv462398 CNV Loss 19166990
nsv830454 CNV Gain+Loss 17160897
esv272655 CNV Insertion 20981092

Variation tolerance for TRIM36 Gene

Residual Variation Intolerance Score: 33.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM36 Gene

HapMap Linkage Disequilibrium report
TRIM36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM36 Gene

Disorders for TRIM36 Gene

Relevant External Links for TRIM36

Genetic Association Database (GAD)
TRIM36
Human Genome Epidemiology (HuGE) Navigator
TRIM36
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM36
genes like me logo Genes that share disorders with TRIM36: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM36 Gene

Publications for TRIM36 Gene

  1. Identification of human HAPRIN potentially involved in the acrosome reaction. (PMID: 15955891) Kitamura K. … Tanaka H. (J. Androl. 2005) 23 67
  2. The RING-finger protein haprin: domains and function in the acrosome reaction. (PMID: 16381605) Kitamura K. … Nishimune Y. (Curr. Protein Pept. Sci. 2005) 23 67
  3. Cloning and characterisation of the RBCC728/TRIM36 zinc-binding protein from the tumor suppressor gene region at chromosome 5q22.3. (PMID: 15145053) Balint I. … Kovacs G. (Gene 2004) 23 67
  4. Haprin, a novel haploid germ cell-specific RING finger protein involved in the acrosome reaction. (PMID: 12917430) Kitamura K. … Nishimune Y. (J. Biol. Chem. 2003) 23 67
  5. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 67

Products for TRIM36 Gene

Sources for TRIM36 Gene

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