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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM36 Gene

protein-coding   GIFtS: 53
GCID: GC05M114460

tripartite motif containing 36

(Previous name: tripartite motif-containing 36 )
 Explore 1 disease affiliated with
TRIM36 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRIM36    

Aliases
for TRIM36 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tripartite Motif Containing 361 2     Zinc-Binding Protein Rbcc7282 3
RBCC7281 2 3 5     RING Finger Protein 982 3
RNF981 2 3     E3 Ubiquitin-Protein Ligase TRIM362
HAPRIN1 2     Tripartite Motif Protein 362
Tripartite Motif-Containing 361 2     EC 6.3.2.-3
Tripartite Motif-Containing Protein 362 3     

External Ids:    HGNC: 162801   Entrez Gene: 555212   Ensembl: ENSG000001525037   OMIM: 6093175   UniProtKB: Q9NQ863   

Export aliases for TRIM36 gene to outside databases

Previous GC identifers: GC05M114064 GC05M114863 GC05M114491 GC05M114536 GC05M114488 GC05M109642


Summaries
for TRIM36 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TRIM36:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively
spliced transcript variants that encode different protein isoforms have been described for this gene. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TRI36_HUMAN, Q9NQ86
Function: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target
proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and
fertilization (By similarity)




Genomic Views
for TRIM36 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TRIM36
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRIM36 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM36

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q22.3   Ensembl cytogenetic band:  5q22.3   HGNC cytogenetic band: 5q22

TRIM36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM36 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M114460:  view genomic region     (about GC identifiers)

Start:
 114,460,459 bp from pter      End:
 114,516,243 bp from pter
Size:
 55,785 bases      Orientation:
 minus strand

Proteins
for TRIM36 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TRI36_HUMAN, Q9NQ86 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM36  
Size: 728 amino acids; 83013 Da
Subunit: Interacts with CENPH (By similarity)
Subcellular location: Cytoplasm (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity).
Cytoplasm, cytoskeleton (By similarity). Note=Found in the acrosomal region of elongated spermatids and mature sperm
(By similarity)
Secondary accessions: A1L3Z1 A6NDD0 Q0P5Z9
Alternative splicing: 3 isoforms:  Q9NQ86-1   Q9NQ86-2   Q9NQ86-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIM36: NX_Q9NQ86

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NQ86

    • TRIM36 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001017397.1  NP_001017398.1  NP_061170.2  

    ENSEMBL proteins: 
     ENSP00000282369   ENSP00000423934   ENSP00000424259   ENSP00000424743   ENSP00000368938  
     ENSP00000368937  
    Reactome Protein details: Q9NQ86
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: TRIM36
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    Novus Biologicals TRIM36 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TRIM36

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005622intracellular ----
    GO:0005856cytoskeleton IEA--


    TRIM36 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TRIM36

    Protein Domains /
    Families
    for TRIM36 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRIM36 for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR017903 COS_domain
     IPR003961 Fibronectin_type3

    Graphical View of Domain Structure for InterPro Entry Q9NQ86

    ProtoNet protein and cluster: Q9NQ86

    2 Blocks protein families:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: TRI36_HUMAN, Q9NQ86
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 2 B box-type zinc fingers
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 COS domain
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 1 RING-type zinc finger


    Function
    for TRIM36 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TRI36_HUMAN, Q9NQ86
    Function: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target
    proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and
    fertilization (By similarity)

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM36
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM36 (see all 42):
    hsa-miR-142-5p hsa-miR-3685 hsa-miR-302d hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-503 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: TRIM36 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM36 (see all 7)
    OriGene shRNA RFP: TRIM36
    OriGene siRNA: TRIM36
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM36 (see all 6)
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    Cell Line
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    Search LifeMap BioReagents cell lines for TRIM36

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--


    TRIM36 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for TRIM36:
     Increased cell death in HCC-19  Synthetic lethal with Ras 


    Pathways & Interactions
    for TRIM36 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Polyubiquitination of substrate0.75
    		Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    		Immune System1.00
    		Adaptive Immune System0.59

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for TRIM36
        Antigen processing: Ubiquitination & Proteasome degradation
    Polyubiquitination of substrate
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System



    TRIM36 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM36

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TRIM36 (Q9NQ863 ENSP000002823694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2HP622563, ENSP000003478364I2D: score=2 STRING: ENSP00000347836
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007340acrosome reaction IEA--


    TRIM36 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRIM36 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRIM36 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM36
    1 Novoseek chemical compound relationship for TRIM36 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 44.7 1 15955891 (1)

    Search CenterWatch for drugs/clinical trials and news about TRIM36 / TRI36 

    Transcripts
    for TRIM36 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRIM36 gene (3 alternative transcripts): 
    NM_001017397.1  NM_001017398.1  NM_018700.3  

    Unigene Clusters for TRIM36:

    Tripartite motif containing 36
    Hs.519514  [show with all ESTs], Hs.638953
    Unigene Representative Sequences: NM_018700, BC017346
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282369(uc003kqs.3 uc003kqt.3) ENST00000513154(uc011cwc.2)
    ENST00000514154 ENST00000513485 ENST00000515104 ENST00000510222 ENST00000508894
    ENST00000379618(uc003kqu.2) ENST00000511701 ENST00000379617(uc003kqv.3)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM36
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM36 (see all 42):
    hsa-miR-142-5p hsa-miR-3685 hsa-miR-302d hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-503 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: TRIM36 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM36 (see all 7)
    OriGene shRNA RFP: TRIM36
    OriGene siRNA: TRIM36
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM36
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM36 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): TRIM36 (NM_001017397)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM36
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM36 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIM36
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM36
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM36

    Additional cDNA sequence: BC017346.2 

    10 DOTS entries:

    DT.208888  DT.208028  DT.120823272  DT.101965570  DT.75100116  DT.100752090  DT.120823270  DT.120823283 
    DT.95164514  DT.95164515 

    24/91 AceView cDNA sequences (see all 91):

    BC045164 AW662755 BC046096 AI815874 BI827379 CD243850 AI656257 Z39003 
    BU178369 AI199066 AK058179 AW182803 AI624894 BF727080 BI094427 C00402 
    Z45842 BF592910 NM_018700 AI655864 BF956733 BI460066 AI148450 AA725861 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM36 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
    SP1:              -     -     -     -     -           -     -     -                                                                           
    SP2:              -     -     -     -     -     -     -     -     -                                                                           
    SP3:                                                  -     -     -                                                                           
    SP4:                                      -           -     -     -                                                                           
    SP5:                                      -     -     -     -     -                                                                           


    ECgene alternative splicing isoforms for TRIM36

    Expression
    for TRIM36 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM36 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCGGCAGGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TRIM36 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    ES-J1 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Long-time differentiated EBs (Derivation of embryo...)
    Short-term differentiated embryoid bodies (Derivation of embryo...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TRIM36 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM36

    SOURCE GeneReport for Unigene clusters: Hs.519514 Hs.638953

    UniProtKB/Swiss-Prot: TRI36_HUMAN, Q9NQ86
    Tissue specificity: Highly expressed in testis, prostate and brain. Weakly expressed in kidney, lung and heart

        SABiosciences Expression via Pathway-Focused PCR Array including TRIM36: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for TRIM36 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM36 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Trim361 , 5 tripartite motif-containing 361, 5 86.58(n)1
    92.58(a)1    		   18 (24.41 cM)5
    281051  NM_178872.41  NP_849203.21 
     461653025 
    chicken
    (Gallus gallus)    		 Aves TRIM361 tripartite motif containing 36 72.98(n)
    74.01(a)    		   426811  XM_424421.3  XP_424421.3 
    lizard
    (Anolis carolinensis)    		 Reptilia TRIM366
    		 --
    		 77(a)
    		 1 ↔ 1
    		 GL343193.1(8049869-8079667)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.69262 Xenopus laevis transcribed sequence with weak similarity more 75.64(n)    CA985379.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.284462 Danio rerio cDNA clone MGC63476 IMAGE2600826, complete more 73.3(n)    BC056765.1 


    ENSEMBL Gene Tree for TRIM36 (if available)
    TreeFam Gene Tree for TRIM36 (if available) 

    Paralogs
    for TRIM36 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM36 gene
    TRIM132  FSD1L2  TRIM462  TRIM632  TRIM592  TRIM672  TRIM92  MID22  
    MID12  TRIM552  TRIM542  FSD12  
    4 SIMAP similar genes for TRIM36 using alignment to 5 protein entries:     TRI36_HUMAN (see all proteins):
    TRIM46    TRIM5    TRIM59    MID2

    TRIM36 for paralogs           About GeneDecksing



    Genomic Variants
    for TRIM36 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1087 NCBI SNPs in TRIM36 are shown (see all 1087)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1491144571,2
    		--114460037(+) ATAACA/GTTTGG 1 -- ds50010--------
    rs1431137341,2
    		--114460125(+) TAGTCA/CAGATA 1 -- ds50010--------
    rs1847201641,2
    		--114460186(+) TTATTA/GTTAGC 1 -- ds50010--------
    rs1871862251,2
    		--114460232(+) ATATTA/TAAAAA 1 -- ds50010--------
    rs1418247051,2
    		--114460308(+) AAGCT-/AATA  
                AATAA     		1 -- ds50010--------
    rs119546671,2
    		H--114460314(+) ATAAAA/TAAATG 1 -- ds50010--------
    rs728117801,2
    		C,--114460326(+) TCAAAA/GTGATT 1 -- ds50010--------
    rs1845994391,2
    		--114460373(+) CTAATA/CATCTT 1 -- ds50010--------
    rs1388541061,2
    		--114460388(+) TAATCA/GGTTTG 1 -- ds50010--------
    rs38055961,2
    		C,F,H,--114460539(-) ATAGGA/GTAGCT 1 -- ut3114Minor allele frequency- G:0.15NS EA NA 2216

    HapMap Linkage Disequilibrium report for TRIM36 (114460459 - 114516243 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TRIM36
         1 CNV: 4473

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    Disorders / Diseases
    for TRIM36 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRIM36 for disorders           About GeneDecksing

    OMIM gene information: 609317    OMIM disorders: --

    1 disease for TRIM36:    About MalaCards
    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: TRIM36 (1 document)

    Export disorders for TRIM36 gene to outside databases

    Publications
    for TRIM36 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM36 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with TRIM36)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterisation of the RBCC728/TRIM36 zinc-binding protein from the tumor suppressor gene region at chromosome 5q22.3. (PubMed id 15145053)1, 2, 9 Balint I.... Kovacs G. (2004)
    2. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 3 Reymond A.... Ballabio A. (2001)
    3. Identification of human HAPRIN potentially involved in the acrosome reaction. (PubMed id 15955891)1, 9 Kitamura K....Tanaka H. (2005)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
    6. TRIM36 interacts with the kinetochore protein CENP-H and delays cell cycle progression. (PubMed id 19232519)1 Miyajima N....Hatakeyama S. (2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Haprin, a novel haploid germ cell-specific RING finger protein involved in the acrosome reaction. (PubMed id 12917430)9 Kitamura K....Nishimune Y. (2003)

    External Searches for TRIM36 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TRIM36 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55521 HGNC: 16280 AceView: TRIM36 Ensembl:ENSG00000152503 euGenes: HUgn55521
    ECgene: TRIM36 H-InvDB: TRIM36

    Other Databases showing TRIM36 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TRIM36 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM36 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TRIM36 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TRIM36 gene:
    Search GeneIP for patents involving TRIM36

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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