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TRIM36 Gene

protein-coding   GIFtS: 56
GCID: GC05M114460

Tripartite Motif Containing 36

(Previous name: tripartite motif-containing 36)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 361 2     Tripartite Motif-Containing Protein 362 3
RING Finger Protein 981 2 3     RNF982 3
Zinc-Binding Protein Rbcc7281 2 3     HAPRIN2
RBCC7282 3 5     E3 Ubiquitin-Protein Ligase TRIM362
Tripartite Motif-Containing 361 2     EC 6.3.2.-3
Tripartite Motif Protein 361 2     

External Ids:    HGNC: 162801   Entrez Gene: 555212   Ensembl: ENSG000001525037   OMIM: 6093175   UniProtKB: Q9NQ863   

Export aliases for TRIM36 gene to outside databases

Previous GC identifers: GC05M114064 GC05M114863 GC05M114491 GC05M114536 GC05M114488 GC05M109642


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIM36 Gene:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively
spliced transcript variants that encode different protein isoforms have been described for this gene. (provided
by RefSeq, Jul 2008)

GeneCards Summary for TRIM36 Gene:
TRIM36 (tripartite motif containing 36) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is TRIM13.

UniProtKB/Swiss-Prot: TRI36_HUMAN, Q9NQ86
Function: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of
target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome
reaction and fertilization (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TRIM36
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM36 promoter sequence
   Search Chromatin IP Primers for TRIM36

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q22.3   Ensembl cytogenetic band:  5q22.3   HGNC cytogenetic band: 5q22

TRIM36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM36 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M114460:  view genomic region     (about GC identifiers)

Start:
114,460,459 bp from pter      End:
114,516,243 bp from pter
Size:
55,785 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TRI36_HUMAN, Q9NQ86 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM36  
Size: 728 amino acids; 83013 Da
Subunit: Interacts with CENPH (By similarity)
Secondary accessions: A1L3Z1 A6NDD0 B7Z3V4 B7ZAV7 E9PFI8 Q0P5Z9
Alternative splicing: 4 isoforms:  Q9NQ86-1   Q9NQ86-2   Q9NQ86-3   Q9NQ86-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIM36: NX_Q9NQ86

Explore proteomics data for TRIM36 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRIM36 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001017397.1  NP_001017398.1  NP_061170.2  

    ENSEMBL proteins: 
     ENSP00000282369   ENSP00000423934   ENSP00000424259   ENSP00000424743   ENSP00000368938  
     ENSP00000368937  
    Reactome Protein details: Q9NQ86

    TRIM36 Human Recombinant Protein Products:

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    Novus Biologicals TRIM36 Proteins
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIM36

     
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    antibodies-online proteins for TRIM36 (5 products) 

     
    antibodies-online peptides for TRIM36

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 13):
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR017903 COS_domain
     IPR003961 Fibronectin_type3

    Graphical View of Domain Structure for InterPro Entry Q9NQ86

    ProtoNet protein and cluster: Q9NQ86

    2 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: TRI36_HUMAN, Q9NQ86
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 2 B box-type zinc fingers
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 COS domain
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with TRIM36           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI36_HUMAN, Q9NQ86
    Function: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of
    target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome
    reaction and fertilization (By similarity)

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with TRIM36           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRIM36:
     Increased cell death in HCC-19  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TRIM36

    miRNA
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    miRTarBase miRNAs that target TRIM36:
    hsa-mir-142-3p (MIRT021589), hsa-mir-26b-5p (MIRT050046), hsa-mir-32-5p (MIRT028267), hsa-mir-132-3p (MIRT021747), hsa-mir-128-3p (MIRT021969)

    Block miRNA regulation of human, mouse, rat TRIM36 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM36 (see all 42):
    hsa-miR-142-5p hsa-miR-3685 hsa-miR-302d hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-503 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidTRIM36 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRIM36

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    GenScript: all cDNA clones in your preferred vector (see all 3): TRIM36 (NM_001017397)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM36


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRI36_HUMAN, Q9NQ86: Cytoplasm (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity).
    Cytoplasm, cytoskeleton (By similarity). Note=Found in the acrosomal region of elongated spermatids and mature
    sperm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton2
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005622intracellular ----
    GO:0005856cytoskeleton IEA--

    Find genes that share ontologies with TRIM36           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRIM36 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84


    Find genes that share SuperPaths with TRIM36           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for TRIM36
        Antigen processing: Ubiquitination & Proteasome degradation


        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM36: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TRIM36

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TRIM36 (Q9NQ863 ENSP000002823694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2HP622563, ENSP000003478364I2D: score=2 STRING: ENSP00000347836
    DCCENSP000003891404STRING: ENSP00000389140
    NEO1ENSP000002619084STRING: ENSP00000261908
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007340acrosome reaction IEA--
    GO:0051726regulation of cell cycle IEA--

    Find genes that share ontologies with TRIM36           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM36 (TRI36)

    1 Novoseek inferred chemical compound relationship for TRIM36 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 44.7 1 15955891 (1)



    Find genes that share compounds with TRIM36           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRIM36 gene (3 alternative transcripts): 
    NM_001017397.1  NM_001017398.1  NM_018700.3  

    Unigene Clusters for TRIM36:

    Tripartite motif containing 36
    Hs.519514  [show with all ESTs], Hs.638953
    Unigene Representative Sequences: NM_018700, BC017346
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282369(uc003kqs.3 uc003kqt.3) ENST00000513154(uc011cwc.2)
    ENST00000514154 ENST00000513485 ENST00000515104 ENST00000510222 ENST00000508894
    ENST00000379618(uc003kqu.2) ENST00000511701 ENST00000379617(uc003kqv.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TRIM36 (see all 42):
    hsa-miR-142-5p hsa-miR-3685 hsa-miR-302d hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-503 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidTRIM36 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TRIM36
      QuantiFast Probe-based Assays in human, mouse, rat TRIM36

    Additional mRNA sequence: BC017346.2 

    10 DOTS entries:

    DT.208888  DT.208028  DT.120823272  DT.101965570  DT.75100116  DT.100752090  DT.120823270  DT.120823283 
    DT.95164514  DT.95164515 

    Selected AceView cDNA sequences (see all 91):

    Z39003 BF727080 BI094427 AI815874 BC046096 AI199066 AK058179 AW182803 
    BF592910 AI624894 AI656257 Z45842 C00402 BI827379 BC045164 BU178369 
    CD243850 AI655864 NM_018700 AW662755 AI990713 BI460066 BE048231 AA725836 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRIM36 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
    SP1:              -     -     -     -     -           -     -     -                                                                           
    SP2:              -     -     -     -     -     -     -     -     -                                                                           
    SP3:                                                  -     -     -                                                                           
    SP4:                                      -           -     -     -                                                                           
    SP5:                                      -     -     -     -     -                                                                           


    ECgene alternative splicing isoforms for TRIM36

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM36 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGGCAGGTT
    TRIM36 Expression
    About this image


    TRIM36 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Long-time differentiated EBs
             sperm   
     
     NULL (Uncategorized)
             Short-term differentiated embryoid bodies
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Inner Cell Mass (Early Embryonic Tissues)
             ES-J1
    TRIM36 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM36 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.519514 Hs.638953

    UniProtKB/Swiss-Prot: TRI36_HUMAN, Q9NQ86
    Tissue specificity: Highly expressed in testis, prostate and brain. Weakly expressed in kidney, lung and heart

        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM36: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM36

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRIM36 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim361 , 5 tripartite motif-containing 361, 5 86.58(n)1
    92.58(a)1
      18 (24.41 cM)5
    281051  NM_178872.41  NP_849203.21 
     461653025 
    chicken
    (Gallus gallus)
    Aves TRIM361 tripartite motif containing 36 73.02(n)
    74.01(a)
      426811  XM_004949685.1  XP_004949742.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRIM366
    tripartite motif containing 36
    77(a)
    1 ↔ 1
    GL343193.1(8047857-8089026)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.69262 Xenopus laevis transcribed sequence with weak similarity more 75.64(n)    CA985379.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.284462 Danio rerio cDNA clone MGC63476 IMAGE2600826, complete more 73.3(n)    BC056765.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Trim96
    Trim9
    19(a)
    1 → many
    2L(10544881-10627374)
    worm
    (Caenorhabditis elegans)
    Secernentea trim-96
    Protein TRIM-9, isoform b (trim-9) mRNA, complete ...
    19(a)
    1 → many
    V(1223897-1235445) WBGene00016539


    ENSEMBL Gene Tree for TRIM36 (if available)
    TreeFam Gene Tree for TRIM36 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM36 gene
    TRIM132  FSD1L2  TRIM462  TRIM632  TRIM592  TRIM92  TRIM672  TRIM552  
    MID12  MID22  TRIM542  FSD12  
    3 SIMAP similar genes for TRIM36 using alignment to 3 protein entries:     TRI36_HUMAN (see all proteins):
    TRIM46    TRIM5    TRIM59

    Find genes that share paralogs with TRIM36           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM36 (see all 1346)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1491144571,2
    --114460037(+) ATAACA/GTTTGG 1 -- ds50010--------
    rs1431137341,2
    --114460125(+) TAGTCA/CAGATA 1 -- ds50010--------
    rs1847201641,2
    --114460186(+) TTATTA/GTTAGC 1 -- ds50010--------
    rs1871862251,2
    --114460232(+) ATATTA/TAAAAA 1 -- ds50010--------
    rs1418247051,2
    C--114460308(+) AAGCT-/AATA  
            
    AATAA
    1 -- ds50010--------
    rs119546671,2
    H--114460314(+) ATAAAA/TAAATG 1 -- ds50010--------
    rs728117801,2
    C--114460326(+) TCAAAA/GTGATT 1 -- ds50010--------
    rs1845994391,2
    --114460373(+) CTAATA/CATCTT 1 -- ds50010--------
    rs1388541061,2
    --114460388(+) TAATCA/GGTTTG 1 -- ds50010--------
    rs38055961,2
    C,F,H--114460539(-) ATAGGA/GTAGCT 1 -- ut3114Minor allele frequency- G:0.15NS EA NA 2216

    HapMap Linkage Disequilibrium report for TRIM36 (114460459 - 114516243 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TRIM36:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv272655CNV Insertion20981092
    nsv462398CNV Loss19166990
    nsv830453CNV Gain17160897
    nsv882729CNV Gain21882294
    nsv830454CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM36
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM36

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609317    OMIM disorders: --


    Find genes that share disorders with TRIM36           About GenesLikeMe

    Genetic Association Database (GAD): TRIM36
    Human Genome Epidemiology (HuGE) Navigator: TRIM36 (1 document)

    Export disorders for TRIM36 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM36 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with TRIM36)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterisation of the RBCC728/TRIM36 zinc-binding protein from the tumor suppressor gene region at chromosome 5q22.3. (PubMed id 15145053)1, 2, 9 Balint I.... Kovacs G. (Gene 2004)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 3 Reymond A.... Ballabio A. (EMBO J. 2001)
    4. Identification of human HAPRIN potentially involved in the acrosome reaction. (PubMed id 15955891)1, 9 Kitamura K....Tanaka H. (J. Androl. 2005)
    5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    6. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (Genome Res. 2009)
    7. TRIM36 interacts with the kinetochore protein CENP-H and delays cell cycle progression. (PubMed id 19232519)1 Miyajima N....Hatakeyama S. (Biochem. Biophys. Res. Commun. 2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55521 HGNC: 16280 AceView: TRIM36 Ensembl:ENSG00000152503 euGenes: HUgn55521
    ECgene: TRIM36 H-InvDB: TRIM36

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRIM36 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM36 gene:
    Search GeneIP for patents involving TRIM36

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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