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TRIM35 Gene

protein-coding   GIFtS: 44
GCID: GC08M027142

Tripartite Motif Containing 35

(Previous name: tripartite motif-containing 35)
  Search for TRIM35
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 351 2     MAIR2
Tripartite Motif-Containing 351 2     Tripartite Motif-Containing Protein 352
Hemopoietic Lineage Switch Protein 52 3     KIAA10983
HLS52 3     

External Ids:    HGNC: 162851   Entrez Gene: 230872   Ensembl: ENSG000001042287   UniProtKB: Q9UPQ43   

Export aliases for TRIM35 gene to outside databases

Previous GC identifers: GC08M026944 GC08M027647 GC08M027164 GC08M027198 GC08M025687


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIM35 Gene:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this
protein has not been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRIM35 Gene:
TRIM35 (tripartite motif containing 35) is a protein-coding gene. An important paralog of this gene is TRIM31.

UniProtKB/Swiss-Prot: TRI35_HUMAN, Q9UPQ4
Function: May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM35 gene promoter:
         STAT1   NRSF form 1   STAT3   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM35 promoter sequence
   Search Chromatin IP Primers for TRIM35

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM35


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.2   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p21.2

TRIM35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM35 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M027142:  view genomic region     (about GC identifiers)

Start:
27,142,404 bp from pter      End:
27,168,836 bp from pter
Size:
26,433 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRI35_HUMAN, Q9UPQ4 (See protein sequence)
Recommended Name: Tripartite motif-containing protein 35  
Size: 493 amino acids; 56540 Da
Sequence caution: Sequence=BAA83050.1; Type=Erroneous initiation;
Secondary accessions: Q86XQ0 Q8WVA4
Alternative splicing: 2 isoforms:  Q9UPQ4-1   Q9UPQ4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIM35: NX_Q9UPQ4

Explore proteomics data for TRIM35 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRIM35 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_741983.2  
    ENSEMBL proteins: 
     ENSP00000301924   ENSP00000429356   ENSP00000428770  

    TRIM35 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TRIM35

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    Cloud-Clone Corp. CLIAs for TRIM35


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 9):
     IPR006574 PRY
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q9UPQ4

    ProtoNet protein and cluster: Q9UPQ4

    4 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: TRI35_HUMAN, Q9UPQ4
    Domain: The RING finger domain and the coiled-coil region are required for the apoptosis-inducing activity (By
    similarity)
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    TRIM35 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI35_HUMAN, Q9UPQ4
    Function: May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    TRIM35 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM35
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM35
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    Selected qRT-PCR Assays for microRNAs that regulate TRIM35 (see all 9):
    hsa-miR-424 hsa-miR-187* hsa-miR-15a hsa-miR-561 hsa-miR-205* hsa-miR-16 hsa-miR-195 hsa-miR-497
    SwitchGear 3'UTR luciferase reporter plasmidTRIM35 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TRIM35 (NM_171982)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM35
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM35

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM35


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRI35_HUMAN, Q9UPQ4: Cytoplasm (By similarity). Nucleus (By similarity). Note=Found predominantly in cytoplasm
    with a granular distribution. Found in punctuate nuclear bodies (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ISS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ISS--

    TRIM35 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRIM35
    Interactions:

        Search GeneGlobe Interaction Network for TRIM35

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for TRIM35 (Q9UPQ43 ENSP000003019244) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSG101Q998163, ENSP000002519684I2D: score=2 STRING: ENSP00000251968
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process ISS--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0043065positive regulation of apoptotic process IDA14662771
    GO:0045087innate immune response IDA18248090
    GO:0045930negative regulation of mitotic cell cycle IDA14662771

    TRIM35 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM35 (TRI35)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRIM35 gene: 
    NM_171982.3  

    Unigene Cluster for TRIM35:

    Tripartite motif containing 35
    Hs.104223  [show with all ESTs]
    Unigene Representative Sequence: NM_171982
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305364(uc003xfl.1 uc010lup.1 uc003xfm.1) ENST00000521283
    ENST00000521253 ENST00000519219
    miRNA
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    Block miRNA regulation of human, mouse, rat TRIM35 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM35 (see all 9):
    hsa-miR-424 hsa-miR-187* hsa-miR-15a hsa-miR-561 hsa-miR-205* hsa-miR-16 hsa-miR-195 hsa-miR-497
    SwitchGear 3'UTR luciferase reporter plasmidTRIM35 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TRIM35
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM35
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIM35 (NM_171982)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM35
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM35
    Primer
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    OriGene qPCR primer pairs and template standards for TRIM35
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM35
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM35
      QuantiTect SYBR Green Assays in human, mouse, rat TRIM35
      QuantiFast Probe-based Assays in human, mouse, rat TRIM35

    Additional mRNA sequence: 

    AB029021.1 AF492463.1 AK308236.1 BC018337.1 BC069226.1 

    5 DOTS entries:

    DT.443640  DT.100021843  DT.205310  DT.95369680  DT.40263284 

    Selected AceView cDNA sequences (see all 98):

    AB029021 BU622420 AA861940 BQ060736 BE674344 NM_171982 CB178062 BM090689 
    BC069226 BG757187 BQ877812 BQ931984 AA700074 AF492463 CF125208 BM466284 
    AI075822 BU607501 AA115933 BM931950 AI272949 AA614569 NM_015066 CA307081 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM35    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
    SP1:                                                        -         
    SP2:                    -                                             
    SP3:                                                                  
    SP4:                                                                  
    SP5:                    -     -                                       


    ECgene alternative splicing isoforms for TRIM35

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM35 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCTGGTTG
    TRIM35 Expression
    About this image


    TRIM35 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Mesonephros
    TRIM35 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM35 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.104223
        Custom PCR Arrays for TRIM35
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM35

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM35 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim351 , 5 tripartite motif-containing 351, 5 81.78(n)1
    81.91(a)1
      14 (34.44 cM)5
    668541  NM_029979.31  NP_084255.21 
     662970315 
    chicken
    (Gallus gallus)
    Aves TRIM351 tripartite motif containing 35 66.88(n)
    57.51(a)
      771180  XM_001234475.3  XP_001234476.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    43(a)
    43(a)
    1 ↔ many
    1 ↔ many
    5(63148378-63149698)
    GL343547.1(451227-489688)
    zebrafish
    (Danio rerio)
    Actinopterygii trim35-246
    trim35-356
    (see all 43)
    tripartite motif containing 35-35
    (see all 43)
    35(a)
    35(a)
    (see all 43)
    1 ↔ many
    1 ↔ many
    (see all 43)
    3(8142643-8148240) ENSDARG00000080004
    22(39914870-39918084) ENSDARG00000052310


    ENSEMBL Gene Tree for TRIM35 (if available)
    TreeFam Gene Tree for TRIM35 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM35 gene
    TRIM312  TRIM502  TRIM102  TRIM732  TRIM692  TRIM152  TRIM262  TRIM742  
    TRIM522  TRIM622  TRIM412  TRIM722  
    8 SIMAP similar genes for TRIM35 using alignment to 3 protein entries:     TRI35_HUMAN (see all proteins):
    TRIM41    TRIM39    BMI1    RAD18    TRIM26    TRIM5
    TRIM22    TRIM60

    TRIM35 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM35 (see all 537)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1921133741,2
    --27141919(+) CAGGTA/GGCCTA 1 -- ds50010--------
    rs558377921,2
    C--27141970(+) TGTGAC/TGGGAC 1 -- ds50013Minor allele frequency- T:0.07NA EA 242
    rs736815121,2
    C,F--27141987(+) GACTCC/TGGGTA 1 -- ds50012Minor allele frequency- T:0.05WA 120
    rs1834388911,2
    --27142009(+) TGCAGC/TGACAA 1 -- ds50010--------
    rs1869547981,2
    --27142049(+) CACTGC/TAGCGG 1 -- ds50010--------
    rs47330471,2
    C,F,A,H--27142157(+) AGAGAG/ACTGCT 1 -- ds500125Minor allele frequency- A:0.39NA NS EA WA 2670
    rs1442629261,2
    --27142271(+) CGCTTC/TCTGCC 1 -- ds50010--------
    rs101042511,2
    C,F,H--27142300(+) TCCCTG/AAGCCA 1 -- ds50014Minor allele frequency- A:0.00NS EA 412
    rs1177499141,2
    C,F--27142319(+) AACTTA/CCATGG 1 -- ds50011Minor allele frequency- C:0.02NA 120
    rs1396336141,2
    --27142356(+) TTTCTA/GGGATA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TRIM35 (27142404 - 27168836 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TRIM35: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM35
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM35

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM35 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with TRIM35)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member isolated from a hemopoietic lineage switch, is a candidate tumor suppressor. (PubMed id 14662771)1, 2, 3 Lalonde J.-P.... Klinken S.P. (J. Biol. Chem. 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Cloning and characterization of a novel RING-B-box-coiled-coil protein with apoptotic function. (PubMed id 12692137)1, 3 Kimura F....Motoyoshi K. (J. Biol. Chem. 2003)
    4. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 3 Reymond A.... Ballabio A. (EMBO J. 2001)
    5. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    6. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    7. Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. (PubMed id 23105109)1 Hayes S.D....UrbAc S. (J. Biol. Chem. 2012)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    9. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (Genome Res. 2009)
    10. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (Mol. Syst. Biol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23087 HGNC: 16285 AceView: TRIM35 Ensembl:ENSG00000104228 euGenes: HUgn23087
    ECgene: TRIM35 H-InvDB: TRIM35

    (According to HUGE)
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    HUGE: KIAA1098

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TRIM35 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM35 gene:
    Search GeneIP for patents involving TRIM35

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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