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Aliases for TRIM35 Gene

Aliases for TRIM35 Gene

  • Tripartite Motif Containing 35 2 3 5
  • Hemopoietic Lineage Switch Protein 5 3 4
  • HLS5 3 4
  • Tripartite Motif-Containing Protein 35 3
  • Tripartite Motif-Containing 35 2
  • KIAA1098 4
  • MAIR 3

External Ids for TRIM35 Gene

Previous GeneCards Identifiers for TRIM35 Gene

  • GC08M026944
  • GC08M027647
  • GC08M027164
  • GC08M025687
  • GC08M027142

Summaries for TRIM35 Gene

Entrez Gene Summary for TRIM35 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM35 Gene

TRIM35 (Tripartite Motif Containing 35) is a Protein Coding gene. Among its related pathways are Interactome of polycomb repressive complex 2 (PRC2) and Interferon gamma signaling. An important paralog of this gene is TRIM69.

UniProtKB/Swiss-Prot for TRIM35 Gene

  • Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439). Involved in the cell death mechanism (By similarity).

Additional gene information for TRIM35 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM35 Gene

Genomics for TRIM35 Gene

Regulatory Elements for TRIM35 Gene

Enhancers for TRIM35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H027330 1.9 FANTOM5 Ensembl ENCODE dbSUPER 21.6 -22.4 -22381 6 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 YY1 FOS PTK2B TRIM35 EPHX2 CLU CHRNA2 MIR6842
GH08H027314 1.5 Ensembl ENCODE dbSUPER 10.1 -4.2 -4220 1 HDGF PKNOX1 FOXA2 ATF1 ARNT ARID4B BRCA1 ZNF2 TCF12 ZNF766 TRIM35 CHRNA2 PTK2B MIR6842
GH08H027308 1.4 ENCODE dbSUPER 10.1 +0.6 632 4 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 FOS TRIM35 ELP3 CHRNA2 EPHX2 PIR41134
GH08H027273 1.5 Ensembl ENCODE dbSUPER 9.3 +36.7 36747 1 PKNOX1 ATF1 ZNF2 YY1 ZNF766 FOS ATF7 SP3 GTF2B NFYC TRIM35 PIR41134 STMN4
GH08H027280 1.4 FANTOM5 ENCODE dbSUPER 9.3 +29.6 29621 2 BCOR FOXA2 JUN ZMYM3 MAX NFXL1 FOSL1 ZNF664 HIC1 GATA3 STMN4 TRIM35 PTK2B PIR41134
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM35 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000222586 419 2201 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 FOS

Genomic Location for TRIM35 Gene

Chromosome:
8
Start:
27,284,886 bp from pter
End:
27,311,319 bp from pter
Size:
26,434 bases
Orientation:
Minus strand

Genomic View for TRIM35 Gene

Genes around TRIM35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM35 Gene

Proteins for TRIM35 Gene

  • Protein details for TRIM35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPQ4-TRI35_HUMAN
    Recommended name:
    Tripartite motif-containing protein 35
    Protein Accession:
    Q9UPQ4
    Secondary Accessions:
    • Q86XQ0
    • Q8WVA4

    Protein attributes for TRIM35 Gene

    Size:
    493 amino acids
    Molecular mass:
    56540 Da
    Quaternary structure:
    • Interacts with PKM isoform M2, but not isoform M1; this interaction may compete with that between PKM and FGFR1, and hence reduces FGFR1-dependent tyrosine phosphorylation of PKM.
    SequenceCaution:
    • Sequence=BAA83050.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM35 Gene

Post-translational modifications for TRIM35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM35 Gene

No data available for DME Specific Peptides for TRIM35 Gene

Domains & Families for TRIM35 Gene

Gene Families for TRIM35 Gene

Suggested Antigen Peptide Sequences for TRIM35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UPQ4

UniProtKB/Swiss-Prot:

TRI35_HUMAN :
  • The RING finger domain and the coiled-coil region are required for the apoptosis-inducing activity.
  • Belongs to the TRIM/RBCC family.
Domain:
  • The RING finger domain and the coiled-coil region are required for the apoptosis-inducing activity.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM35: view

Function for TRIM35 Gene

Molecular function for TRIM35 Gene

UniProtKB/Swiss-Prot Function:
Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439). Involved in the cell death mechanism (By similarity).

Phenotypes From GWAS Catalog for TRIM35 Gene

Gene Ontology (GO) - Molecular Function for TRIM35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM35: view
genes like me logo Genes that share phenotypes with TRIM35: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TRIM35
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM35 Gene

Localization for TRIM35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM35 Gene

Cytoplasm. Nucleus. Note=Found predominantly in cytoplasm with a granular distribution. Found in punctuate nuclear bodies (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM35 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRIM35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with TRIM35: view

Pathways & Interactions for TRIM35 Gene

genes like me logo Genes that share pathways with TRIM35: view

Pathways by source for TRIM35 Gene

Gene Ontology (GO) - Biological Process for TRIM35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process ISS --
GO:0043065 positive regulation of apoptotic process IDA 14662771
GO:0045087 innate immune response IDA 18248090
GO:0045930 negative regulation of mitotic cell cycle IDA 14662771
GO:1902187 negative regulation of viral release from host cell IDA 18248090
genes like me logo Genes that share ontologies with TRIM35: view

No data available for SIGNOR curated interactions for TRIM35 Gene

Drugs & Compounds for TRIM35 Gene

No Compound Related Data Available

Transcripts for TRIM35 Gene

Unigene Clusters for TRIM35 Gene

Tripartite motif containing 35:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TRIM35
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM35 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2: -
SP3:
SP4:
SP5: - -

Relevant External Links for TRIM35 Gene

GeneLoc Exon Structure for
TRIM35
ECgene alternative splicing isoforms for
TRIM35

Expression for TRIM35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM35 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x4.3).

Protein differential expression in normal tissues from HIPED for TRIM35 Gene

This gene is overexpressed in Bone marrow stromal cell (42.1), Urinary Bladder (15.7), and Colon muscle (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM35 Gene



NURSA nuclear receptor signaling pathways regulating expression of TRIM35 Gene:

TRIM35

SOURCE GeneReport for Unigene cluster for TRIM35 Gene:

Hs.104223

Evidence on tissue expression from TISSUES for TRIM35 Gene

  • Lung(4.2)
  • Nervous system(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with TRIM35: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM35 Gene

Orthologs for TRIM35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM35 33 34
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia TRIM35 33 34
  • 89.45 (n)
cow
(Bos Taurus)
Mammalia TRIM35 33 34
  • 88.08 (n)
rat
(Rattus norvegicus)
Mammalia Trim35 33
  • 82.25 (n)
mouse
(Mus musculus)
Mammalia Trim35 33 16 34
  • 81.78 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIM35 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM35 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM35 33 34
  • 66.88 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 43 (a)
OneToMany
-- 34
  • 43 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TRIM35 (34 of 43) 34
  • 35 (a)
OneToMany
TRIM35 (42 of 43) 34
  • 35 (a)
OneToMany
trim35-24 34
  • 35 (a)
OneToMany
trim35-35 34
  • 35 (a)
OneToMany
trim35-36 34
  • 35 (a)
OneToMany
trim35-37 34
  • 35 (a)
OneToMany
TRIM35 (39 of 43) 34
  • 34 (a)
OneToMany
TRIM35 (40 of 43) 34
  • 34 (a)
OneToMany
trim35-19 34
  • 34 (a)
OneToMany
trim35-20 34
  • 34 (a)
OneToMany
trim35-22 34
  • 34 (a)
OneToMany
trim35-23 34
  • 34 (a)
OneToMany
trim35-25 34
  • 34 (a)
OneToMany
trim35-33 34
  • 34 (a)
OneToMany
trim35-38 34
  • 34 (a)
OneToMany
TRIM35 (15 of 43) 34
  • 33 (a)
OneToMany
TRIM35 (18 of 43) 34
  • 33 (a)
OneToMany
TRIM35 (41 of 43) 34
  • 33 (a)
OneToMany
trim35-10 34
  • 33 (a)
OneToMany
trim35-21 34
  • 33 (a)
OneToMany
trim35-3 34 34
  • 33 (a)
OneToMany
trim35-39 34
  • 33 (a)
OneToMany
trim35-31 34
  • 32 (a)
OneToMany
trim35-34 34
  • 32 (a)
OneToMany
trim35-7 34
  • 32 (a)
OneToMany
TRIM35 (14 of 43) 34
  • 31 (a)
OneToMany
TRIM35 (38 of 43) 34
  • 31 (a)
OneToMany
TRIM35 (8 of 43) 34
  • 31 (a)
OneToMany
trim35-13 34
  • 31 (a)
OneToMany
trim35-29 34
  • 31 (a)
OneToMany
TRIM35 (22 of 43) 34
  • 30 (a)
OneToMany
TRIM35 (2 of 43) 34
  • 29 (a)
OneToMany
TRIM35 (6 of 43) 34
  • 29 (a)
OneToMany
trim35-28 34
  • 29 (a)
OneToMany
trim35-30 34
  • 29 (a)
OneToMany
TRIM35 (7 of 43) 34
  • 28 (a)
OneToMany
trim35-12 34
  • 28 (a)
OneToMany
trim35-40 34
  • 28 (a)
OneToMany
TRIM35 (36 of 43) 34
  • 27 (a)
OneToMany
trim35-1 34
  • 27 (a)
OneToMany
TRIM35 (43 of 43) 34
  • 25 (a)
OneToMany
trim35-27 34
  • 25 (a)
OneToMany
Species where no ortholog for TRIM35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM35 Gene

ENSEMBL:
Gene Tree for TRIM35 (if available)
TreeFam:
Gene Tree for TRIM35 (if available)

Paralogs for TRIM35 Gene

(8) SIMAP similar genes for TRIM35 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM35: view

Variants for TRIM35 Gene

Sequence variations from dbSNP and Humsavar for TRIM35 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000016605 -- 27,298,383(+) CAAAG(C/T)CACGG intron-variant
rs1000072560 -- 27,292,381(+) AACTG(A/C)CTAAT intron-variant
rs1000123031 -- 27,292,683(+) TAGCA(G/T)TTTTT intron-variant
rs1000130425 -- 27,299,243(+) ACCAC(C/T)AGAGT intron-variant
rs1000135689 -- 27,311,637(+) AACCT(A/C)AGGCC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TRIM35 Gene

Variant ID Type Subtype PubMed ID
dgv1390e214 CNV gain 21293372
esv3616717 CNV gain 21293372
esv3616719 CNV loss 21293372

Variation tolerance for TRIM35 Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM35 Gene

Disorders for TRIM35 Gene

Relevant External Links for TRIM35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM35

No disorders were found for TRIM35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM35 Gene

Publications for TRIM35 Gene

  1. HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member isolated from a hemopoietic lineage switch, is a candidate tumor suppressor. (PMID: 14662771) Lalonde JP … Klinken SP (The Journal of biological chemistry 2004) 2 3 4 60
  2. TRIM35 Interacts with pyruvate kinase isoform M2 to suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma. (PMID: 25263439) Chen Z … He X (Oncogene 2015) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Cloning and characterization of a novel RING-B-box-coiled-coil protein with apoptotic function. (PMID: 12692137) Kimura F … Motoyoshi K (The Journal of biological chemistry 2003) 2 3 60
  5. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A … Ballabio A (The EMBO journal 2001) 2 3 60

Products for TRIM35 Gene

Sources for TRIM35 Gene

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