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Aliases for TRIM35 Gene

Aliases for TRIM35 Gene

  • Tripartite Motif Containing 35 2 3 5
  • Hemopoietic Lineage Switch Protein 5 3 4
  • Tripartite Motif-Containing 35 2 3
  • HLS5 3 4
  • KIAA1098 4
  • MAIR 3

External Ids for TRIM35 Gene

Previous GeneCards Identifiers for TRIM35 Gene

  • GC08M026944
  • GC08M027647
  • GC08M027164
  • GC08M025687
  • GC08M027142

Summaries for TRIM35 Gene

Entrez Gene Summary for TRIM35 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM35 Gene

TRIM35 (Tripartite Motif Containing 35) is a Protein Coding gene. Among its related pathways are Immune System and Interferon gamma signaling. An important paralog of this gene is TRIM50.

UniProtKB/Swiss-Prot for TRIM35 Gene

  • May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM35 Gene

Genomics for TRIM35 Gene

Regulatory Elements for TRIM35 Gene

Promoters for TRIM35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM35 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM35 Gene

Chromosome:
8
Start:
27,284,886 bp from pter
End:
27,311,319 bp from pter
Size:
26,434 bases
Orientation:
Minus strand

Genomic View for TRIM35 Gene

Genes around TRIM35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM35 Gene

Proteins for TRIM35 Gene

  • Protein details for TRIM35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPQ4-TRI35_HUMAN
    Recommended name:
    Tripartite motif-containing protein 35
    Protein Accession:
    Q9UPQ4
    Secondary Accessions:
    • Q86XQ0
    • Q8WVA4

    Protein attributes for TRIM35 Gene

    Size:
    493 amino acids
    Molecular mass:
    56540 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA83050.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM35 Gene

Proteomics data for TRIM35 Gene at MOPED

Post-translational modifications for TRIM35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM35 Gene

Antibody Products

No data available for DME Specific Peptides for TRIM35 Gene

Domains & Families for TRIM35 Gene

Gene Families for TRIM35 Gene

Suggested Antigen Peptide Sequences for TRIM35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UPQ4

UniProtKB/Swiss-Prot:

TRI35_HUMAN :
  • The RING finger domain and the coiled-coil region are required for the apoptosis-inducing activity.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Domain:
  • The RING finger domain and the coiled-coil region are required for the apoptosis-inducing activity.
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM35: view

Function for TRIM35 Gene

Molecular function for TRIM35 Gene

UniProtKB/Swiss-Prot Function:
May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity).
genes like me logo Genes that share phenotypes with TRIM35: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TRIM35

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM35 Gene

Localization for TRIM35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM35 Gene

Cytoplasm. Nucleus. Note=Found predominantly in cytoplasm with a granular distribution. Found in punctuate nuclear bodies (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM35 Gene COMPARTMENTS Subcellular localization image for TRIM35 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for TRIM35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with TRIM35: view

Pathways & Interactions for TRIM35 Gene

genes like me logo Genes that share pathways with TRIM35: view

Pathways by source for TRIM35 Gene

Gene Ontology (GO) - Biological Process for TRIM35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045930 negative regulation of mitotic cell cycle IDA 14662771
genes like me logo Genes that share ontologies with TRIM35: view

No data available for SIGNOR curated interactions for TRIM35 Gene

Drugs & Compounds for TRIM35 Gene

No Compound Related Data Available

Transcripts for TRIM35 Gene

Unigene Clusters for TRIM35 Gene

Tripartite motif containing 35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM35 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2: -
SP3:
SP4:
SP5: - -

Relevant External Links for TRIM35 Gene

GeneLoc Exon Structure for
TRIM35
ECgene alternative splicing isoforms for
TRIM35

Expression for TRIM35 Gene

mRNA expression in normal human tissues for TRIM35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM35 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x4.3).

Protein differential expression in normal tissues from HIPED for TRIM35 Gene

This gene is overexpressed in Bone marrow stromal cell (42.1), Urinary Bladder (15.7), and Colon muscle (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM35 Gene



SOURCE GeneReport for Unigene cluster for TRIM35 Gene Hs.104223

genes like me logo Genes that share expression patterns with TRIM35: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRIM35 Gene

Orthologs for TRIM35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM35 36
  • 100 (a)
OneToOne
TRIM35 35
  • 99.53 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia TRIM35 35
  • 88.08 (n)
  • 88.62 (a)
TRIM35 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM35 36
  • 91 (a)
OneToOne
TRIM35 35
  • 89.45 (n)
  • 91.28 (a)
mouse
(Mus musculus)
Mammalia Trim35 16
Trim35 36
  • 78 (a)
OneToOne
Trim35 35
  • 81.78 (n)
  • 81.91 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIM35 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM35 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim35 35
  • 82.25 (n)
  • 81.71 (a)
chicken
(Gallus gallus)
Aves TRIM35 35
  • 66.88 (n)
  • 57.51 (a)
TRIM35 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 43 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TRIM35 (14 of 43) 36
  • 31 (a)
OneToMany
TRIM35 (15 of 43) 36
  • 33 (a)
OneToMany
TRIM35 (18 of 43) 36
  • 33 (a)
OneToMany
TRIM35 (2 of 43) 36
  • 29 (a)
OneToMany
TRIM35 (22 of 43) 36
  • 30 (a)
OneToMany
TRIM35 (34 of 43) 36
  • 35 (a)
OneToMany
TRIM35 (36 of 43) 36
  • 27 (a)
OneToMany
TRIM35 (38 of 43) 36
  • 31 (a)
OneToMany
TRIM35 (39 of 43) 36
  • 34 (a)
OneToMany
TRIM35 (40 of 43) 36
  • 34 (a)
OneToMany
TRIM35 (41 of 43) 36
  • 33 (a)
OneToMany
TRIM35 (42 of 43) 36
  • 35 (a)
OneToMany
TRIM35 (43 of 43) 36
  • 25 (a)
OneToMany
TRIM35 (6 of 43) 36
  • 29 (a)
OneToMany
TRIM35 (7 of 43) 36
  • 28 (a)
OneToMany
TRIM35 (8 of 43) 36
  • 31 (a)
OneToMany
trim35-1 36
  • 27 (a)
OneToMany
trim35-10 36
  • 33 (a)
OneToMany
trim35-12 36
  • 28 (a)
OneToMany
trim35-13 36
  • 31 (a)
OneToMany
trim35-19 36
  • 34 (a)
OneToMany
trim35-20 36
  • 34 (a)
OneToMany
trim35-21 36
  • 33 (a)
OneToMany
trim35-22 36
  • 34 (a)
OneToMany
trim35-23 36
  • 34 (a)
OneToMany
trim35-24 36
  • 35 (a)
OneToMany
trim35-25 36
  • 34 (a)
OneToMany
trim35-27 36
  • 25 (a)
OneToMany
trim35-28 36
  • 29 (a)
OneToMany
trim35-29 36
  • 31 (a)
OneToMany
trim35-3 36
  • 33 (a)
OneToMany
trim35-3 36
  • 33 (a)
OneToMany
trim35-30 36
  • 29 (a)
OneToMany
trim35-31 36
  • 32 (a)
OneToMany
trim35-33 36
  • 34 (a)
OneToMany
trim35-34 36
  • 32 (a)
OneToMany
trim35-35 36
  • 35 (a)
OneToMany
trim35-36 36
  • 35 (a)
OneToMany
trim35-37 36
  • 35 (a)
OneToMany
trim35-38 36
  • 34 (a)
OneToMany
trim35-39 36
  • 33 (a)
OneToMany
trim35-40 36
  • 28 (a)
OneToMany
trim35-7 36
  • 32 (a)
OneToMany
Species with no ortholog for TRIM35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM35 Gene

ENSEMBL:
Gene Tree for TRIM35 (if available)
TreeFam:
Gene Tree for TRIM35 (if available)

Paralogs for TRIM35 Gene

Paralogs for TRIM35 Gene

(8) SIMAP similar genes for TRIM35 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM35: view

Variants for TRIM35 Gene

Sequence variations from dbSNP and Humsavar for TRIM35 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs939268 -- 27,297,169(+) AGCCA(A/G)ATGTT intron-variant
rs2322602 -- 27,299,790(+) gagag(C/T)ttggg intron-variant
rs4054956 -- 27,303,725(+) TCTCA(C/T)TCTTC intron-variant
rs4733047 -- 27,284,640(+) AGAGA(A/G)CTGCT downstream-variant-500B
rs7813625 -- 27,301,942(+) actgc(C/T)cactg intron-variant

Variation tolerance for TRIM35 Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM35 Gene

HapMap Linkage Disequilibrium report
TRIM35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TRIM35 Gene

Disorders for TRIM35 Gene

Relevant External Links for TRIM35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM35

No disorders were found for TRIM35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM35 Gene

Publications for TRIM35 Gene

  1. HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member isolated from a hemopoietic lineage switch, is a candidate tumor suppressor. (PMID: 14662771) Lalonde J.-P. … Klinken S.P. (J. Biol. Chem. 2004) 2 3 4 67
  2. Cloning and characterization of a novel RING-B-box-coiled-coil protein with apoptotic function. (PMID: 12692137) Kimura F. … Motoyoshi K. (J. Biol. Chem. 2003) 2 3
  3. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3
  4. TRIM35 Interacts with pyruvate kinase isoform M2 to suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma. (PMID: 25263439) Chen Z. … He X. (Oncogene 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for TRIM35 Gene

Sources for TRIM35 Gene

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