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Aliases for TRIM34 Gene

Aliases for TRIM34 Gene

  • Tripartite Motif Containing 34 2 3
  • RNF21 3 4 6
  • IFP1 3 4 6
  • Interferon-Responsive Finger Protein 1 3 4
  • Tripartite Motif-Containing 34 2 3
  • Ring Finger Protein 21, Interferon-Responsive 3
  • Tripartite Motif-Containing Protein 34 3
  • RING Finger Protein 21 4
  • EC 6.3.2 63

External Ids for TRIM34 Gene

Previous HGNC Symbols for TRIM34 Gene

  • RNF21

Previous GeneCards Identifiers for TRIM34 Gene

  • GC11P006372
  • GC11P005920
  • GC11P005583
  • GC11P005582
  • GC11P005584
  • GC11P005574
  • GC11P005602
  • GC11P005300
  • GC11P005619

Summaries for TRIM34 Gene

Entrez Gene Summary for TRIM34 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]

GeneCards Summary for TRIM34 Gene

TRIM34 (Tripartite Motif Containing 34) is a Protein Coding gene. An important paralog of this gene is TRIM58.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM34 Gene

Genomics for TRIM34 Gene

Regulatory Elements for TRIM34 Gene

Genomic Location for TRIM34 Gene

5,619,764 bp from pter
5,644,398 bp from pter
24,635 bases
Plus strand

Genomic View for TRIM34 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM34 Gene

Proteins for TRIM34 Gene

  • Protein details for TRIM34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 34
    Protein Accession:
    Secondary Accessions:
    • D3DQS7
    • Q9C016
    • Q9HCR0
    • Q9HCR1
    • Q9HCR2

    Protein attributes for TRIM34 Gene

    488 amino acids
    Molecular mass:
    56864 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG53517.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB17050.1; Type=Miscellaneous discrepancy; Note=The in vivo relevance of this transcript of the TRIM6 (AC Q9C030) and TRIM34 genes creating a chimeric protein of 842 residues is uncertain.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM34 Gene

    Alternative splice isoforms for TRIM34 Gene


neXtProt entry for TRIM34 Gene

Proteomics data for TRIM34 Gene at MOPED

Selected DME Specific Peptides for TRIM34 Gene

Post-translational modifications for TRIM34 Gene

  • Ubiquitination at Lys173
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM34 Gene

Antibody Products

Domains for TRIM34 Gene

Suggested Antigen Peptide Sequences for TRIM34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM34: view

Function for TRIM34 Gene

Molecular function for TRIM34 Gene

UniProtKB/Swiss-Prot Induction:
Isoform 1 is up-regulated by interferons.

Enzyme Numbers (IUBMB) for TRIM34 Gene

Gene Ontology (GO) - Molecular Function for TRIM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM34: view

Phenotypes for TRIM34 Gene

GenomeRNAi human phenotypes for TRIM34:
genes like me logo Genes that share phenotypes with TRIM34: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM34

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM34 Gene

Localization for TRIM34 Gene

Subcellular locations from

Jensen Localization Image for TRIM34 Gene COMPARTMENTS Subcellular localization image for TRIM34 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA 17156811
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRIM34: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM34 Gene

Pathways for TRIM34 Gene

SuperPathways for TRIM34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IDA 23077300
GO:0060333 interferon-gamma-mediated signaling pathway TAS --
GO:0070206 protein trimerization IDA 17156811
genes like me logo Genes that share ontologies with TRIM34: view

No data available for Pathways by source for TRIM34 Gene

Transcripts for TRIM34 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM34

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM34 Gene

No ASD Table

Relevant External Links for TRIM34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM34 Gene

mRNA expression in normal human tissues for TRIM34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TRIM34 Gene

This gene is overexpressed in Fetal testis (36.4) and Fetal heart (21.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TRIM34 Gene

mRNA Expression by UniProt/SwissProt for TRIM34 Gene

Tissue specificity: Isoform 1 is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes.
genes like me logo Genes that share expressions with TRIM34: view

Expression partners for TRIM34 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TRIM34 Gene

Orthologs for TRIM34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM34 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM34 35
  • 99.52 (n)
  • 99.18 (a)
TRIM34 36
  • 99 (a)
(Mus musculus)
Mammalia Trim34a 16
Trim34a 36
  • 28 (a)
(Bos Taurus)
Mammalia -- 36
  • 42 (a)
(Gallus gallus)
Aves -- 36
  • 14 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 14 (a)
Species with no ortholog for TRIM34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM34 Gene

Gene Tree for TRIM34 (if available)
Gene Tree for TRIM34 (if available)

Paralogs for TRIM34 Gene

(18) SIMAP similar genes for TRIM34 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM34: view

Variants for TRIM34 Gene

Sequence variations from dbSNP and Humsavar for TRIM34 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_052141 -
VAR_019826 -
VAR_019825 -

Structural Variations from Database of Genomic Variants (DGV) for TRIM34 Gene

Variant ID Type Subtype PubMed ID
nsv896939 CNV Loss 21882294
nsv896947 CNV Loss 21882294

Relevant External Links for TRIM34 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM34 Gene

Disorders for TRIM34 Gene

No disorders were found for TRIM34 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TRIM34 Gene

Publications for TRIM34 Gene

  1. Molecular cloning of ring finger protein 21 (RNF21)/interferon- responsive finger protein (ifp1), which possesses two RING-B box- coiled coil domains in tandem. (PMID: 11013086) Orimo A. … Muramatsu M. (Genomics 2000) 3 4 23
  2. Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. (PMID: 16775307) Li X. … Sodroski J. (J. Virol. 2006) 3 23
  3. Unique features of TRIM5alpha among closely related human TRIM family members. (PMID: 17156811) Li X. … Sodroski J. (Virology 2007) 3 23
  4. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for TRIM34 Gene

Sources for TRIM34 Gene

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