TRIM34 Gene
protein-coding GIFtS: 41
GCID: GC11P005619
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|
tripartite motif containing 34(Previous name: tripartite motif-containing 34 )
(Previous symbol: RNF21)
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Aliases
for TRIM34 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tripartite Motif Containing 341 2 | | Ring Finger Protein 21, Interferon-Responsive2 | | RNF211 2 3 5 | | Tripartite Motif-Containing Protein 342 | | IFP12 3 5 | | RING Finger Protein 213 | | Tripartite Motif-Containing 341 2 | | EC 6.3.28 | | Interferon-Responsive Finger Protein 12 3 | | |
Export aliases for TRIM34 gene to outside databasesPrevious GC identifers: GC11P006372 GC11P005920 GC11P005583 GC11P005582 GC11P005584 GC11P005574 GC11P005602 GC11P005300 |
Summaries
for TRIM34 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TRIM34:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this geneis up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster.Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 genehas also been observed, which results in a fusion product from these neighboring family members. (provided by RefSeq,Oct 2010)
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Genomic Views
for TRIM34 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRIM34 gene promoter:
MEF-2A CREB deltaCREB MEF-2 aMEF-2 STAT5A
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIM34
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM34 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15TRIM34 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P005619: view genomic region
(about GC identifiers)
Start:
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5,617,946 bp from pter |
End:
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5,665,628 bp from pter |
Size:
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47,683 bases |
Orientation:
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plus strand |
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Proteins
for TRIM34 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRI34_HUMAN, Q9BYJ4 (See
protein sequence)Recommended Name: Tripartite motif-containing protein 34 Size: 488 amino acids; 56864 Da
Sequence caution: Sequence=AAG53517.1; Type=Erroneous initiation; Sequence=BAB17050.1; Type=Miscellaneous discrepancy;Note=The biological existence and relevance of this transcript that contains the product of both TRIM6 (AC Q9C030) andTRIM34 genes creating a chimeric protein of 842 residues is uncertain;
1 PDB 3D structure from  and Proteopedia  for TRIM34:2EGP (3D)
Secondary accessions: D3DQS7 Q9C016 Q9HCR0 Q9HCR1 Q9HCR2Alternative splicing: 2 isoforms: Q9BYJ4-1 Q9BYJ4-2 Explore the universe of human proteins at neXtProt for TRIM34: NX_Q9BYJ4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BYJ4
4/5 DME Specific Peptides for TRIM34 (Q9BYJ4) (see all 5)
TRIM34 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001003827.1 NP_067629.2 NP_569074.2
ENSEMBL proteins: ENSP00000422947 ENSP00000402595 ENSP00000338711 ENSP00000395982
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
TRIM34 for ontologies About GeneDecksing
TRIM34 Antibody Products:
Assay Products for TRIM34: |
Protein
Domains /
Families
for TRIM34 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIM34 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry Q9BYJ4ProtoNet protein and cluster: Q9BYJ4 2 Blocks protein families: IPB000315 B-box zinc finger signature IPB001841 Zn-finger
UniProtKB/Swiss-Prot: TRI34_HUMAN, Q9BYJ4Similarity: Belongs to the TRIM/RBCC familySimilarity: Contains 1 B box-type zinc fingerSimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 RING-type zinc finger |
Function
for TRIM34 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TRI34_HUMAN, Q9BYJ4Induction: Isoform 1 is up-regulated by interferonsEnzyme Number (IUBMB): EC 6.3.22
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM34 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM34 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
TRIM34 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TRIM34:
|
Pathways & Interactions
for TRIM34 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM34
3 Interacting proteins for TRIM34 (Q9BYJ43) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
TRIM34 for ontologies About GeneDecksing
|
Drugs & Compounds
for TRIM34 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRIM34
Search CenterWatch for drugs/clinical trials and news about TRIM34 / TRI34
|
Transcripts
for TRIM34 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRIM34 gene (4 alternative transcripts): NM_001003827.1 NM_021616.5 NM_130390.2 NM_130389.3 6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000514226(uc001mbh.3) ENST00000429814(uc001mbi.3) ENST00000491385(uc001mbj.3)
ENST00000495668 ENST00000337072 ENST00000457787
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM34 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM34 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): TRIM34 (NM_130390) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM34 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM34 |
24/143 AceView cDNA sequences (see all 143): AI650258 CD242511 AA769791 AA588100 AK027664 BE873135 AA625445 AA227117 BE503226 AI650537 BE220093 BM989990 BE669989 AV661318 CR624250 NM_001003827 AK023210 NM_058166 BX503815 NM_021616 AW612116 BE501740 AB039902 NM_130389
GeneLoc Exon Structure
|
Expression
for TRIM34 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRIM34 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TRIM34 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIM34
UniProtKB/Swiss-Prot: TRI34_HUMAN, Q9BYJ4Tissue specificity: Isoform 1 is the most abundant form. It is highly expressed in the placenta, spleen, colon andperipheral blood leukocytes
SABiosciences Custom PCR Arrays for TRIM34
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM34
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TRIM34 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM34 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM34 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM34 |
Orthologs
for TRIM34 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TRIM34 gene from 2/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
TRIM586 |
-- |
33(a) |
1 → many |
GL343252.1(1250786-1269672) |
zebrafish
(Danio rerio) |
Actinopterygii |
trim476 |
tripartite motif containing 47 |
22(a) |
possible ortholog |
10(26752552-26762609) |
ENSEMBL Gene Tree for TRIM34 (if available)
TreeFam Gene Tree for TRIM34 (if available) |
Paralogs
for TRIM34 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRIM34 gene
- TRIM42 TRIM72 TRIM262 TRIM392 TRIML12 TRIM272 TRIM582 TRIM682
- TRIM102 TRIM152 TRIM602 TRIM222 TRIM172 TRIM52 TRIM62 TRIM6-TRIM342
- TRIM212 TRIM382 TRIM39-RPP212 TRIM112
18/21 SIMAP similar genes for TRIM34 using alignment to 1 protein entry: TRI34_HUMAN(see all similar genes):TRIM6-TRIM34 TRIM5 TRIM22 TRIM6 DKFZp781D1977 TRIM21
TRIM68 TRIM58 TRIM38 TRIM11 TRIM48 TRIM60
TRIM17 TRIM43 TRIML1 TRIM27 TRIM64C TRIM39
TRIM34 for paralogs About GeneDecksing
|
Genomic Variants
for TRIM34 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRIM34 (5617946 - 5665628 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TRIM34
1 CNV: 34458 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TRIM34 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRIM34 for disorders About GeneDecksing
OMIM gene information: 605684
OMIM disorders: --
1  disease for TRIM34: About MalaCardssevere acute respiratory syndrome
1 disease from the University of Copenhagen DISEASES database for TRIM34:Severe acute respiratory syndrome Export disorders for TRIM34 gene to outside databases
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Publications
for TRIM34 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRIM34 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with TRIM34) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of ring finger protein 21 (RNF21)/interferon- responsive finger protein (ifp1), which possesses two RING-B box- coiled coil domains in tandem. (PubMed id 11013086)1, 2, 9 Orimo A.... Muramatsu M. (2000)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2 Reymond A.... Ballabio A. (2001)
- Unique features of TRIM5alpha among closely related human TRIM family members. (PubMed id 17156811)1, 9 Li X....Sodroski J. (2007)
- Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. (PubMed id 16775307)1, 9 Li X....Sodroski J. (2006)
- Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Determinants of the higher order association of the re striction factor TRIM5alpha and other tripartite motif (TRIM) proteins. (PubMed id 21680743)1 Li X....Sodroski J. (2011)
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External Searches for TRIM34 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TRIM34 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRIM34 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRIM34 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TRIM34 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TRIM34 gene:
Search GeneIP for patents involving TRIM34
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRIM34 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIM34 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM34 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM34 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM34 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM34 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM34 |
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| |  |  |  |  | | | | |
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 | | | TRIM34 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM34 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM34 |
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