TRIM33 Gene
protein-coding GIFtS: 59
GCID: GC01M114935
|
|
tripartite motif containing 33(Previous name: tripartite motif-containing 33 )
| |
Aliases
for TRIM33 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tripartite Motif Containing 331 2 | | TIF1-Gamma1 | | RFG71 2 3 5 | | RET-Fused Gene 7 Protein2 3 | | TIF1G1 2 3 5 | | FLJ114291 | | PTC71 2 5 | | ECTO2 | | TF1G1 2 | | E3 Ubiquitin-Protein Ligase TRIM332 | | TIF1GAMMA1 2 | | Transcriptional Intermediary Factor 1 Gamma2 | | TIFGAMMA1 2 | | EC 6.3.2.-3 | | Tripartite Motif-Containing 331 2 | | Transcription Intermediary Factor 1-Gamma3 | | KIAA11131 3 | | Tripartite Motif-Containing Protein 333 | | Ectodermin Homolog2 3 | | EC 6.3.28 | | Protein Rfg72 3 | | |
Export aliases for TRIM33 gene to outside databasesPrevious GC identifers: GC01M115353 GC01M113822 GC01M114035 GC01M114238 GC01M114652 GC01M112793 |
Summaries
for TRIM33 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TRIM33:
The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact withthis protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includesthree zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternativelyspliced transcript variants for this gene have been described, however, the full-length nature of one variant has notbeen determined. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TRI33_HUMAN, Q9UPN9Function: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation viathe ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenousSMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signalingcascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroiddifferentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor ofSMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stablecomplex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade)
Gene Wiki entry for TRIM33
|
Genomic Views
for TRIM33 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRIM33 gene promoter:
CREB E2F-1 E2F GATA-3 COMP1 Evi-1 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIM33
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM33 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13.1 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.1TRIM33 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M114935: view genomic region
(about GC identifiers)
Start:
|
114,935,399 bp from pter |
End:
|
115,053,781 bp from pter |
Size:
|
118,383 bases |
Orientation:
|
minus strand |
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Proteins
for TRIM33 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRI33_HUMAN, Q9UPN9 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase TRIM33 Size: 1127 amino acids; 122533 Da
Subunit: Homooligomer and heterooligomer with TRIM24 and TRIM28 family members. Interacts with SMAD4 in unstimulatedcells. Found in a complex with SMAD2 and SMAD3 upon addition of TGF-beta. Interacts with SMAD2 and SMAD3. Interactswith SMAD4 under basal and induced conditions and, upon TGF-beta signaling, with activated SMAD2. Forms a ternarycomplex with SMAD4 and SMAD2 upon TGF-beta signaling
Subcellular location: Nucleus. Note=In discrete nuclear dots resembling nuclear bodies (By similarity)
Sequence caution: Sequence=AAD17259.1; Type=Frameshift; Positions=1114; Sequence=BAA83065.1; Type=Erroneous initiation;Note=Translation N-terminally shortened; Sequence=CAI13548.1; Type=Erroneous gene model prediction;Sequence=CAI21895.1; Type=Erroneous gene model prediction;
4 PDB 3D structures from  and Proteopedia  for TRIM33:3U5M (3D)
3U5N (3D)
3U5O (3D)
3U5P (3D)
Secondary accessions: O95855 Q5TG72 Q5TG73 Q5TG74 Q9C017 Q9UJ79Alternative splicing: 2 isoforms: Q9UPN9-1 Q9UPN9-2 Explore the universe of human proteins at neXtProt for TRIM33: NX_Q9UPN9
Post-translational modifications:
Sumoylated with SUMO1 (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UPN9
4/13 DME Specific Peptides for TRIM33 (Q9UPN9) (see all 13)
TRIM33 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_056990.3 NP_148980.2
ENSEMBL proteins: ENSP00000351250 ENSP00000358556 ENSP00000402333 ENSP00000412077 Reactome Protein details: Q9UPN9
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
TRIM33 for ontologies About GeneDecksing
TRIM33 Antibody Products:
Assay Products for TRIM33: |
Protein
Domains /
Families
for TRIM33 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIM33 for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry Q9UPN9ProtoNet protein and cluster: Q9UPN9 5 Blocks protein families: IPB000315 B-box zinc finger signature IPB001487 Bromodomain signature IPB001841 Zn-finger IPB001965 Zn-finger-like IPB003649 B-box
UniProtKB/Swiss-Prot: TRI33_HUMAN, Q9UPN9Similarity: Belongs to the TRIM/RBCC familySimilarity: Contains 2 B box-type zinc fingersSimilarity: Contains 1 bromo domainSimilarity: Contains 1 PHD-type zinc fingerSimilarity: Contains 1 RING-type zinc finger |
Function
for TRIM33 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TRI33_HUMAN, Q9UPN9Function: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation viathe ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenousSMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signalingcascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroiddifferentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor ofSMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stablecomplex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade)Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM33 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM33 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TRIM33 (NM_015906) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM33 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRIM33 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM33 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
TRIM33 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for TRIM33:
Animal Models:
Mouse knock-outs for TRIM33: Trim33tm1.2Los Trim33tm1.1Vk
9 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Trim33):
TRIM33 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TRIM33 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | | | 2 | Generic Transcription Pathway | | | 3 | TGF-beta/Smad Signaling | | | 4 | Chromatin Regulation / Acetylation | | | 5 | Signaling by GPCR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Cell Signaling Technology (CST) Pathways for TRIM33
5/6 
Reactome Pathways for TRIM33 (see all 6)
UniProtKB/Swiss-Prot: TRI33_HUMAN, Q9UPN9Pathway: Protein modification; protein ubiquitination
TRIM33 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRIM33
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/57 Interacting proteins for TRIM33 (Q9UPN91, 2, 3 ENSP000003512504) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| SMAD2 | Q157961, 3, ENSP000002621604 | EBI-2214398,EBI-1040141 I2D:
score=2 STRING: ENSP00000262160 | | SMAD3 | P840222, 3, ENSP000003329734 | MINT-8200333 I2D:
score=1 STRING: ENSP00000332973 | | SMAD4 | Q134851, 2, 3, ENSP000003415514 | EBI-2214398,EBI-347263 MINT-8200333 MINT-8200350 I2D:
score=4 STRING: ENSP00000341551 | | RUNX1 | Q011963, ENSP000003003054 | I2D:
score=3 STRING: ENSP00000300305 | | CBFA2T3 | O750813, ENSP000002686794 | I2D:
score=2 STRING: ENSP00000268679 |
About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
TAS | -- | | GO:0006351 | transcription, DNA-dependent |
TAS | -- | | GO:0006367 | transcription initiation from RNA polymerase II promoter |
TAS | -- | | GO:0007179 | transforming growth factor beta receptor signaling pathway |
TAS | -- | | GO:0010467 | gene expression |
TAS | -- |
TRIM33 for ontologies About GeneDecksing
|
Drugs & Compounds
for TRIM33 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRIM33
4 HMDB Compounds for TRIM33 About this table
Search CenterWatch for drugs/clinical trials and news about TRIM33 / TRI33
|
Transcripts
for TRIM33 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRIM33 gene (2 alternative transcripts): NM_015906.3 NM_033020.2 Unigene Cluster for TRIM33: Tripartite motif containing 33 Hs.26837 [show with all ESTs]Unigene Representative Sequence: NM_0159067 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000358465(uc010owr.2 uc010ows.2 uc001eew.3 uc001eex.3)
ENST00000492227 ENST00000369543 ENST00000448034 ENST00000478032 ENST00000476908(uc001eey.1)
ENST00000450349
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM33 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM33 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TRIM33 (NM_015906) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM33 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRIM33 |
Additional cDNA sequence: AB029036.1 AB075517.1 AF119043.1 AF220136.1 AF220137.1 AJ132948.1 AK021491.1 AK023434.1 AK057487.1 AK301997.1 AL080216.1 22 DOTS entries: DT.115377 DT.440693 DT.100785184 DT.95275141 DT.85104409 DT.308745 DT.75102142 DT.423395 DT.95214939 DT.100785185 DT.40215810 DT.75197738 DT.314623 DT.95275138 DT.121389951 DT.85102592 DT.92437326 DT.95141057 DT.95165893 DT.95165904 DT.100660161 DT.100783399 24/365 AceView cDNA sequences (see all 365): BM551415 AI214870 AB029036 AL080216 AL119641 AI610712 BM550799 AA806112 AA630768 AI887680 BF224413 AA860281 AA504332 AA888070 BX501635 AA827148 BU156624 AL041260 BQ632682 AA653693 AA262843 AI244719 BM464384 F05165
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM33 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21a | · | 21b |
|---|
|
| SP1: | | | | | |
| SP2: | | | | | |
| SP3: | | | | | |
| SP4: | | | | | |
| SP5: | | | | |
ECgene alternative splicing isoforms for TRIM33
|
Expression
for TRIM33 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRIM33 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTATTTAAT
About this image
See TRIM33 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIM33
SOURCE GeneReport for Unigene cluster: Hs.26837
UniProtKB/Swiss-Prot: TRI33_HUMAN, Q9UPN9Tissue specificity: Expressed in stem cells at the bottom of the crypts of the colon (at protein level). Expressed incolon adenomas and adenocarcinomas (at protein level). Expressed in brain, lung, liver, spleen, thymus, prostate,kidney, testis, heart, placenta, pancreas, small intestine, ovary, colon, skeletal muscle and hematopoieticprogenitors
SABiosciences Expression via Pathway-Focused PCR Array including TRIM33:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM33
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIM33 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM33 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM33 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM33 |
Orthologs
for TRIM33 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TRIM33 gene from 5/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TRIM331 |
tripartite motif containing 33 |
83.21(n)
93.99(a) |
|
419883 XM_418009.3 XP_418009.3 |
lizard
(Anolis carolinensis) |
Reptilia |
TRIM336 |
-- |
93(a) |
1 ↔ 1 |
4(130169301-130211392) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.328852 |
Xenopus laevis transcribed sequence with moderate similarity more |
78.01(n) |
|
BJ625867.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
trim331 |
tripartite motif-containing 33 |
62.33(n)
62(a) |
|
324053 NM_001002871.1 NP_001002871.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
bon1 , 3 |
peripheral nervous system development
transcription more3
bonus1 |
30(a)3
40.23(n)1
30.73(a)1 |
|
442351 NM_001170194.11 NP_001163665.11 |
ENSEMBL Gene Tree for TRIM33 (if available)
TreeFam Gene Tree for TRIM33 (if available) |
Paralogs
for TRIM33 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRIM33 gene
- TRIM662 TRIM242 TRIM282
5 SIMAP similar genes for TRIM33 using alignment to 3 protein entries: TRI33_HUMAN (see all proteins):AIRE TRIM24 SP110 BRDT ZMYND8
TRIM33 for paralogs About GeneDecksing
|
Genomic Variants
for TRIM33 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRIM33 (114935399 - 115053781 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for TRIM33
5 CNVs: 2322 3306 97474 84482 64651
1 Indel: 44434 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM33 |
|
Disorders
/ Diseases
for TRIM33 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRIM33 for disorders About GeneDecksing
OMIM gene information: 605769
OMIM disorders: 188550
UniProtKB/Swiss-Prot: TRI33_HUMAN, Q9UPN9
Defects in TRIM33 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of thethyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillarycarcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections offibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberrationinvolving TRIM33 is found in thyroid papillary carcinomas. Translocation t(1;10)(p13;q11) with RET. The translocationgenerates the TRIM33/RET (PTC7) oncogene
11  diseases for TRIM33: About MalaCardsmyelomonocytic leukemia chronic myelomonocytic leukemia papillary thyroid carcinoma thyroid carcinoma
thyroiditis hematopoiesis carcinoma leukemia
adenoma adenocarcinoma prostatitis
1 Novoseek disease relationship for TRIM33 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
1.28 |
1 |
10741739 (1) |
Export disorders for TRIM33 gene to outside databases
|
Publications
for TRIM33 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for TRIM33 gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with TRIM33) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TIF1gamma, a novel member of the transcriptional intermediary factor 1 family. (PubMed id 10022127)1, 2, 3, 9 Venturini L....De The H. (1999)
- The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2, 3 Reymond A.... Ballabio A. (2001)
- FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. (PubMed id 19135894)1, 2 Dupont S.... Piccolo S. (2009)
- Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. (PubMed id 16751102)1, 2 He W....Massague J. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. (PubMed id 15820681)1, 2 Dupont S.... Piccolo S. (2005)
- Hetero-oligomerization among the TIF family of RBCC/TRIM domain- containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression. (PubMed id 12096914)1, 2 Peng H.... Rauscher F.J. III (2002)
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
- The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas. (PubMed id 10439047)1, 2 Klugbauer S. and Rabes H.M. (1999)
- Inactivation of TIF1gamma cooperates with Kras to ind uce cystic tumors of the pancreas. (PubMed id 19629168)1, 9 Vincent D.F....Bartholin L. (2009)
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External Searches for TRIM33 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing TRIM33 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing TRIM33 gene
(According to HUGE)
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Specialized Databases showing TRIM33 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for TRIM33 gene:
Search GeneIP for patents involving TRIM33
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TRIM33 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for TRIM33 | | OriGene shRNA RFP for TRIM33 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM33 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM33 | | | OriGene Protein Over-expression Lysate for TRIM33 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRIM33 | | OriGene 3'-UTR Clone for TRIM33 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM33 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM33 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TRIM33 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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