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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM33 Gene

protein-coding   GIFtS: 62
GCID: GC01M114935

Tripartite Motif Containing 33

(Previous name: tripartite motif-containing 33)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tripartite Motif Containing 331 2     ECTO2
RFG72 3 5     TF1G2
TIF1G2 3 5     TIF1GAMMA2
Tripartite Motif-Containing 331 2     TIFGAMMA2
Transcriptional Intermediary Factor 1 Gamma1 2     E3 Ubiquitin-Protein Ligase TRIM332
Ectodermin Homolog2 3     EC 6.3.2.-3
Protein Rfg72 3     KIAA11133
TIF1-gamma2 3     Transcription Intermediary Factor 1-Gamma3
RET-Fused Gene 7 Protein2 3     Tripartite Motif-Containing Protein 333
PTC72 5     EC 6.3.28
Ret-Fused Gene 71     

External Ids:    HGNC: 162901   Entrez Gene: 515922   Ensembl: ENSG000001973237   OMIM: 6057695   UniProtKB: Q9UPN93   

Export aliases for TRIM33 gene to outside databases

Previous GC identifers: GC01M115353 GC01M113822 GC01M114035 GC01M114238 GC01M114652 GC01M112793


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRIM33 Gene:
The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact
with this protein have not yet been identified. The protein is a member of the tripartite motif family. This
motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.
Three alternatively spliced transcript variants for this gene have been described, however, the full-length
nature of one variant has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRIM33 Gene: 
TRIM33 (tripartite motif containing 33) is a protein-coding gene. Diseases associated with TRIM33 include chronic myelomonocytic leukemia, and papillary thyroid carcinoma, and among its related super-pathways are Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer and Gene Expression. GO annotations related to this gene include ubiquitin-protein ligase activity and co-SMAD binding. An important paralog of this gene is TRIM66.

UniProtKB/Swiss-Prot: TRI33_HUMAN, Q9UPN9
Function: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation
via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of
endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP
signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3
stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4
and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers
its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling
cascade)

Gene Wiki entry for TRIM33 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM33 gene promoter:
         CREB   E2F-1   E2F   GATA-3   COMP1   Evi-1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM33 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM33

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.1

TRIM33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM33 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M114935:  view genomic region     (about GC identifiers)

Start:
114,935,399 bp from pter      End:
115,053,781 bp from pter
Size:
118,383 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRI33_HUMAN, Q9UPN9 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM33  
Size: 1127 amino acids; 122533 Da
Subunit: Homooligomer and heterooligomer with TRIM24 and TRIM28 family members. Interacts with SMAD4 in
unstimulated cells. Found in a complex with SMAD2 and SMAD3 upon addition of TGF-beta. Interacts with SMAD2 and
SMAD3. Interacts with SMAD4 under basal and induced conditions and, upon TGF-beta signaling, with activated
SMAD2. Forms a ternary complex with SMAD4 and SMAD2 upon TGF-beta signaling
Subcellular location: Nucleus. Note=In discrete nuclear dots resembling nuclear bodies (By similarity)
Sequence caution: Sequence=AAD17259.1; Type=Frameshift; Positions=1114; Sequence=BAA83065.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened; Sequence=CAI13548.1; Type=Erroneous gene model prediction;
Sequence=CAI21895.1; Type=Erroneous gene model prediction;
4 PDB 3D structures from and Proteopedia for TRIM33:
3U5M (3D)        3U5N (3D)        3U5O (3D)        3U5P (3D)    
Secondary accessions: O95855 Q5TG72 Q5TG73 Q5TG74 Q9C017 Q9UJ79
Alternative splicing: 2 isoforms:  Q9UPN9-1   Q9UPN9-2   

Explore the universe of human proteins at neXtProt for TRIM33: NX_Q9UPN9

Explore proteomics data for TRIM33 at MOPED 

Post-translational modifications:

  • UniProtKB: Sumoylated with SUMO1 (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UPN9

  • 4/13 DME Specific Peptides for TRIM33 (Q9UPN9) (see all 13)
     DGRRSACM  LKLFCETCD  STSSTGSRGS  QVCTSCEDNASA 

    TRIM33 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRIM33 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_056990.3  NP_148980.2  

    ENSEMBL proteins: 
     ENSP00000351250   ENSP00000402333   ENSP00000358556   ENSP00000412077  
    Reactome Protein details: Q9UPN9
    Human Recombinant Protein Products for TRIM33: 
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    OriGene Protein Over-expression Lysate for TRIM33
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    GenScript Custom Purified and Recombinant Proteins Services for TRIM33
    Novus Biologicals TRIM33 Protein
    Novus Biologicals TRIM33 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    TRIM33 for ontologies           About GeneDecksing



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    Abcam antibodies for TRIM33
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TRIM: Tripartite motif containing / Tripartite motif containing
    PHF: Zinc fingers, PHD-type

    IUPHAR Guide to PHARMACOLOGY protein family classification: tripartite motif containing 33 
    TIF1 family

    5/10 InterPro protein domains (see all 10):
     IPR003649 Bbox_C
     IPR017907 Znf_RING_CS
     IPR019786 Zinc_finger_PHD-type_CS
     IPR001841 Znf_RING
     IPR001965 Znf_PHD

    Graphical View of Domain Structure for InterPro Entry Q9UPN9

    ProtoNet protein and cluster: Q9UPN9

    5 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001487 Bromodomain signature
    IPB001841 Zn-finger
    IPB001965 Zn-finger-like
    IPB003649 B-box


    UniProtKB/Swiss-Prot: TRI33_HUMAN, Q9UPN9
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 2 B box-type zinc fingers
    Similarity: Contains 1 bromo domain
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    TRIM33 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI33_HUMAN, Q9UPN9
    Function: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation
    via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of
    endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP
    signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3
    stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4
    and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers
    its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling
    cascade)

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004842ubiquitin-protein ligase activity TAS--
    GO:0005515protein binding IPI19135894
    GO:0008270zinc ion binding NAS--
    GO:0070410co-SMAD binding IPI19135894
         
    TRIM33 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for TRIM33:
     Big cells  Decreased substrate adherent c  Increased S DNA content  Wnt reporter upregulated 

         9 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Trim33):
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size  immune system 
     mortality/aging  nervous system  normal  tumorigenesis 

    TRIM33 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TRIM33: Trim33tm1.2Los Trim33tm1.1Vk

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRIM33 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRIM33

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM33 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM33 

    miRNA
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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM33 (see all 48):
    hsa-miR-429 hsa-miR-548k hsa-miR-371-5p hsa-miR-34b hsa-miR-520g hsa-miR-200b hsa-miR-192* hsa-miR-4273
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of TRIM33 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM33


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRIM33 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer0.63
    Downregulation of SMAD2/3:SMAD4 transcriptional activity0.56
    Signaling by TGF-beta Receptor Complex0.61
    2Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    3Signaling by GPCR
    Signal Transduction0.55
    4TGF-beta/Smad Signaling
    TGF-beta/Smad Signaling
    5Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for TRIM33
        Chromatin Regulation / Acetylation
    TGF-beta/Smad Signaling

    5/6        Reactome Pathways for TRIM33 (see all 6)
        Signaling by TGF-beta Receptor Complex
    Downregulation of SMAD2/3:SMAD4 transcriptional activity
    Generic Transcription Pathway
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Signal Transduction


    UniProtKB/Swiss-Prot: TRI33_HUMAN, Q9UPN9
    Pathway: Protein modification; protein ubiquitination


    TRIM33 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRIM33

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/63 Interacting proteins for TRIM33 (Q9UPN91, 2, 3 ENSP000003512504) via UniProtKB, MINT, STRING, and/or I2D (see all 63)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157961, 3, ENSP000002621604EBI-2214398,EBI-1040141 I2D: score=2 STRING: ENSP00000262160
    SMAD3P840222, 3, ENSP000003329734MINT-8200333 I2D: score=1 STRING: ENSP00000332973
    ENSG00000206454Q018603I2D: score=2 
    ENSG00000229094Q018603I2D: score=2 
    ENSG00000230336Q018603I2D: score=2 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS--
    GO:0006351transcription, DNA-dependent TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--
    GO:0010467gene expression TAS--

    TRIM33 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM33 (TRI33)

    4 HMDB Compounds for TRIM33    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about TRIM33 / TRI33

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRIM33 gene (2 alternative transcripts): 
    NM_015906.3  NM_033020.2  

    Unigene Cluster for TRIM33:

    Tripartite motif containing 33
    Hs.26837  [show with all ESTs]
    Unigene Representative Sequence: NM_015906
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358465(uc010owr.2 uc010ows.2 uc001eew.3 uc001eex.3)
    ENST00000492227 ENST00000478032 ENST00000448034 ENST00000369543 ENST00000476908(uc001eey.1)
    ENST00000450349
    miRNA
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    Additional mRNA sequence: 

    AB029036.1 AB075517.1 AF119043.1 AF220136.1 AF220137.1 AJ132948.1 AK021491.1 AK023434.1 
    AK057487.1 AK301997.1 AL080216.1 

    22 DOTS entries:

    DT.115377  DT.440693  DT.100785184  DT.95275141  DT.85104409  DT.308745  DT.75102142  DT.423395 
    DT.95214939  DT.100785185  DT.40215810  DT.75197738  DT.314623  DT.95275138  DT.121389951  DT.85102592 
    DT.92437326  DT.95141057  DT.95165893  DT.95165904  DT.100660161  DT.100783399 

    24/365 AceView cDNA sequences (see all 365):

    AI199435 AI887680 N66161 AW150339 BM561856 AI810306 AL119641 BQ216999 
    BX090534 AA888070 BX501635 H23670 AA504332 AA630768 AI214870 BU902983 
    CA449409 N25024 AA262763 BF224413 AA481548 AW589233 AA262843 BG674542 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM33    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:        -                                                                                   -     -                 -                                       
    SP2:                                                                                                                                                        -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21a · 21b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for TRIM33

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM33 expression in normal human tissues (normalized intensities)      TRIM33 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTATTTAAT
    TRIM33 Expression
    About this image


    TRIM33 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             cmps   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             superior temporal gyrus   
     
     Breast (Uncategorized)
             breast epithelium   
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord

    See TRIM33 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM33

    SOURCE GeneReport for Unigene cluster: Hs.26837

    UniProtKB/Swiss-Prot: TRI33_HUMAN, Q9UPN9
    Tissue specificity: Expressed in stem cells at the bottom of the crypts of the colon (at protein level). Expressed
    in colon adenomas and adenocarcinomas (at protein level). Expressed in brain, lung, liver, spleen, thymus,
    prostate, kidney, testis, heart, placenta, pancreas, small intestine, ovary, colon, skeletal muscle and
    hematopoietic progenitors

        SABiosciences Expression via Pathway-Focused PCR Array including TRIM33: 
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TRIM33 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim331 , 5 tripartite motif-containing 331, 5 91.68(n)1
    96.18(a)1
      3 (45.25 cM)5
    940931  NM_053170.21  NP_444400.21 
     1032792935 
    chicken
    (Gallus gallus)
    Aves TRIM331 tripartite motif containing 33 83.21(n)
    93.99(a)
      419883  XM_418009.3  XP_418009.3 
    lizard
    (Anolis carolinensis)
    Reptilia TRIM336
    Uncharacterized protein
    93(a)
    1 ↔ 1
    4(130169301-130211392)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.328852 Xenopus laevis transcribed sequence with moderate similarity more 78.01(n)    BJ625867.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trim331 tripartite motif-containing 33 62.33(n)
    62(a)
      324053  NM_001002871.1  NP_001002871.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bon1 , 3 peripheral nervous system development
    transcription more3
    bonus1
    30(a)3
    40.23(n)1
    30.73(a)1
      442351  NM_001170194.11  NP_001163665.11 


    ENSEMBL Gene Tree for TRIM33 (if available)
    TreeFam Gene Tree for TRIM33 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM33 gene
    TRIM662  TRIM242  AIRE2  TRIM282  
    4 SIMAP similar genes for TRIM33 using alignment to 3 protein entries:     TRI33_HUMAN (see all proteins):
    AIRE    SP110    TRIM24    BRDT

    TRIM33 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2297 SNPs in TRIM33 are shown (see all 2297)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0423784
    A lung adenocarcinoma sample4--see VAR_0423782 E K mis40--------
    VAR_0423794
    A glioblastoma multiforme sample4--see VAR_0423792 P S mis40--------
    VAR_0423764
    A glioblastoma multiforme sample4--see VAR_0423762 M I mis40--------
    rs587641751,2
    C--112798776(+) TGTGT-/T/TT  
            
    TTTTT
    4 -- ut311NA 2
    rs1477178591,2
    C--112798779(+) GTTTT-/GTTTTT 2 -- ut310--------
    rs792842811,2
    C--112799210(+) AAAGGA/GAAATT 2 -- int10--------
    rs680702101,2
    C--112813246(+) ACCAA-/TCAA  
            
    AGAAA
    2 -- int11Minor allele frequency- TCAA:0.00NA 2
    rs2011028031,2
    C--112814746(+) AAAAA-/AGAAAGA 2 -- int10--------
    rs716648391,2
    C,F--112814750(+) AAAAAG/AAAAAG 2 -- int13Minor allele frequency- A:0.50NA WA 6
    rs768908561,2
    C--112814776(+) TTTCTG/CAAAAG 2 -- int11Minor allele frequency- C:0.50WA 2

    HapMap Linkage Disequilibrium report for TRIM33 (114935399 - 115053781 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TRIM33:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2474891CNV Deletion19546169
    esv2716485CNV Deletion23290073
    esv2102268CNV Deletion18987734
    esv28734CNV Loss19812545
    nsv831104CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605769   
    OMIM disorders: 188550  
    UniProtKB/Swiss-Prot: TRI33_HUMAN, Q9UPN9
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an
    irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm
    characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered
    with a surface layer of neoplastic epithelial cells. Note=The disease is caused by mutations affecting the gene
    represented in this entry. A chromosomal aberration involving TRIM33 is found in thyroid papillary carcinomas.
    Translocation t(1;10)(p13;q11) with RET. The translocation generates the TRIM33/RET (PTC7) oncogene

  • 8 diseases for TRIM33:    About MalaCards
    chronic myelomonocytic leukemia    papillary thyroid carcinoma    papillary carcinoma    thyroiditis
    adenoma    adenocarcinoma    leukemia    prostatitis


    TRIM33 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TRIM33 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 1.28 1 10741739 (1)

    Genetic Association Database (GAD): TRIM33

    Export disorders for TRIM33 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM33 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with TRIM33)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TIF1gamma, a novel member of the transcriptional intermediary factor 1 family. (PubMed id 10022127)1, 2, 3, 9 Venturini L....De The H. (1999)
    2. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2, 3 Reymond A.... Ballabio A. (2001)
    3. FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. (PubMed id 19135894)1, 2 Dupont S.... Piccolo S. (2009)
    4. Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. (PubMed id 16751102)1, 2 He W....Massague J. (2006)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. (PubMed id 15820681)1, 2 Dupont S.... Piccolo S. (2005)
    7. Hetero-oligomerization among the TIF family of RBCC/TRIM domain- containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression. (PubMed id 12096914)1, 2 Peng H.... Rauscher F.J. III (2002)
    8. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
    9. The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas. (PubMed id 10439047)1, 2 Klugbauer S. and Rabes H.M. (1999)
    10. Inactivation of TIF1gamma cooperates with Kras to ind uce cystic tumors of the pancreas. (PubMed id 19629168)1, 9 Vincent D.F....Bartholin L. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51592 HGNC: 16290 AceView: TRIM33 Ensembl:ENSG00000197323 euGenes: HUgn51592
    ECgene: TRIM33 H-InvDB: TRIM33

    (According to HUGE)
    About This Section
    HUGE: KIAA1113

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM33 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRIM33 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRIM33 gene:
    Search GeneIP for patents involving TRIM33

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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