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TRIM33 Gene

protein-coding   GIFtS: 64
GCID: GC01M114935

Tripartite Motif Containing 33

(Previous name: tripartite motif-containing 33)
  See TRIM33-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 331 2     ECTO2
RFG72 3 5     TF1G2
TIF1G2 3 5     TIF1GAMMA2
Tripartite Motif-Containing 331 2     TIFGAMMA2
Transcriptional Intermediary Factor 1 Gamma1 2     E3 Ubiquitin-Protein Ligase TRIM332
Ectodermin Homolog2 3     EC 6.3.2.-3
Protein Rfg72 3     KIAA11133
TIF1-gamma2 3     Transcription Intermediary Factor 1-Gamma3
RET-Fused Gene 7 Protein2 3     Tripartite Motif-Containing Protein 333
PTC72 5     EC 6.3.28
Ret-Fused Gene 71     

External Ids:    HGNC: 162901   Entrez Gene: 515922   Ensembl: ENSG000001973237   OMIM: 6057695   UniProtKB: Q9UPN93   

Export aliases for TRIM33 gene to outside databases

Previous GC identifers: GC01M115353 GC01M113822 GC01M114035 GC01M114238 GC01M114652 GC01M112793


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIM33 Gene:
The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact
with this protein have not yet been identified. The protein is a member of the tripartite motif family. This
motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.
Three alternatively spliced transcript variants for this gene have been described, however, the full-length
nature of one variant has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRIM33 Gene:
TRIM33 (tripartite motif containing 33) is a protein-coding gene. Diseases associated with TRIM33 include papillary thyroid carcinoma, and follicular thyroid carcinoma. GO annotations related to this gene include ubiquitin-protein ligase activity and co-SMAD binding. An important paralog of this gene is TRIM66.

UniProtKB/Swiss-Prot: TRI33_HUMAN, Q9UPN9
Function: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation
via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of
endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP
signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3
stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4
and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers
its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling
cascade)

Gene Wiki entry for TRIM33 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM33 gene promoter:
         CREB   E2F-1   E2F   GATA-3   COMP1   Evi-1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM33 promoter sequence
   Search Chromatin IP Primers for TRIM33

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.1

TRIM33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM33 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M114935:  view genomic region     (about GC identifiers)

Start:
114,935,399 bp from pter      End:
115,053,781 bp from pter
Size:
118,383 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRI33_HUMAN, Q9UPN9 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM33  
Size: 1127 amino acids; 122533 Da
Subunit: Homooligomer and heterooligomer with TRIM24 and TRIM28 family members. Interacts with SMAD4 in
unstimulated cells. Found in a complex with SMAD2 and SMAD3 upon addition of TGF-beta. Interacts with SMAD2 and
SMAD3. Interacts with SMAD4 under basal and induced conditions and, upon TGF-beta signaling, with activated
SMAD2. Forms a ternary complex with SMAD4 and SMAD2 upon TGF-beta signaling
Sequence caution: Sequence=AAD17259.1; Type=Frameshift; Positions=1114; Sequence=BAA83065.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened; Sequence=CAI13548.1; Type=Erroneous gene model prediction;
Sequence=CAI21895.1; Type=Erroneous gene model prediction;
4 PDB 3D structures from and Proteopedia for TRIM33:
3U5M (3D)        3U5N (3D)        3U5O (3D)        3U5P (3D)    
Secondary accessions: O95855 Q5TG72 Q5TG73 Q5TG74 Q9C017 Q9UJ79
Alternative splicing: 2 isoforms:  Q9UPN9-1   Q9UPN9-2   

Explore the universe of human proteins at neXtProt for TRIM33: NX_Q9UPN9

Explore proteomics data for TRIM33 at MOPED

Post-translational modifications: 

  • Sumoylated with SUMO1 (By similarity)1
  • Ubiquitination2 at Lys394
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TRIM33 (Q9UPN9) (see all 13)
     DGRRSACM  LKLFCETCD  STSSTGSRGS  QVCTSCEDNASA 


    See TRIM33 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_056990.3  NP_148980.2  

    ENSEMBL proteins: 
     ENSP00000351250   ENSP00000402333   ENSP00000358556   ENSP00000412077  
    Reactome Protein details: Q9UPN9

    TRIM33 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TRIM33
    OriGene Protein Over-expression Lysate for TRIM33
    OriGene MassSpec for TRIM33
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    GenScript Custom Purified and Recombinant Proteins Services for TRIM33
    Novus Biologicals TRIM33 Protein
    Novus Biologicals TRIM33 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TRIM33
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TRIM33 

    TRIM33 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for TRIM33  (TIF1G)
    OriGene Antibodies for TRIM33
    OriGene Custom Antibody Services for TRIM33
    Novus Biologicals TRIM33 Antibodies
    Search for Antibodies for TRIM33 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for TRIM33
    LSBio Antibodies in human, mouse, rat for TRIM33

    TRIM33 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TRIM33
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for TRIM33 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers
    PHF: Zinc fingers, PHD-type

    IUPHAR Guide to PHARMACOLOGY protein family classification: tripartite motif containing 33
    TIF1 family

    Selected InterPro protein domains (see all 10):
     IPR003649 Bbox_C
     IPR017907 Znf_RING_CS
     IPR019786 Zinc_finger_PHD-type_CS
     IPR001841 Znf_RING
     IPR001965 Znf_PHD

    Graphical View of Domain Structure for InterPro Entry Q9UPN9

    ProtoNet protein and cluster: Q9UPN9

    5 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001487 Bromodomain signature
    IPB001841 Zn-finger
    IPB001965 Zn-finger-like
    IPB003649 B-box


    UniProtKB/Swiss-Prot: TRI33_HUMAN, Q9UPN9
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 2 B box-type zinc fingers
    Similarity: Contains 1 bromo domain
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with TRIM33           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI33_HUMAN, Q9UPN9
    Function: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation
    via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of
    endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP
    signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3
    stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4
    and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers
    its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling
    cascade)

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004842ubiquitin-protein ligase activity TAS--
    GO:0005515protein binding IPI19135894
    GO:0008270zinc ion binding IEA--
    GO:0070410co-SMAD binding IPI19135894
         
    Find genes that share ontologies with TRIM33           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for TRIM33:
     Big cells  Decreased substrate adherent c  Increased S DNA content  Wnt reporter upregulated 

         9 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Trim33):
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body  immune system 
     mortality/aging  nervous system  normal  tumorigenesis 

    Find genes that share phenotypes with TRIM33           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TRIM33: Trim33tm1.2Los Trim33tm1.1Vk

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM33
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRIM33

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM33
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM33

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRIM33:
    hsa-mir-21-5p (MIRT030846), hsa-mir-19b-3p (MIRT031198), hsa-let-7a-3p (MIRT039002), hsa-mir-744-5p (MIRT037486)

    Block miRNA regulation of human, mouse, rat TRIM33 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM33 (see all 48):
    hsa-miR-429 hsa-miR-548k hsa-miR-371-5p hsa-miR-34b hsa-miR-520g hsa-miR-200b hsa-miR-192* hsa-miR-4273
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRIM33
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM33

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRIM33

    Clone
    Products:
         
    OriGene clones in human, mouse for TRIM33 (see all 13)
    OriGene ORF clones in mouse, rat for TRIM33
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM33 (NM_015906)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM33
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRIM33
    Addgene plasmids for TRIM33 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TRIM33
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRIM33 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM33


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRI33_HUMAN, Q9UPN9: Nucleus. Note=In discrete nuclear dots resembling nuclear bodies (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with TRIM33           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRIM33 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Loss of Function of SMAD2/3 in Cancer
    Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD2/3 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3Signaling by GPCR
    Signal Transduction0.58
    4TGF-beta/Smad Signaling
    TGF-beta/Smad Signaling
    5Disease
    Disease


    Find genes that share SuperPaths with TRIM33           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for TRIM33
        Chromatin Regulation / Acetylation
    TGF-beta/Smad Signaling

    1 Reactome Pathway for TRIM33
        Downregulation of SMAD2/3:SMAD4 transcriptional activity


    UniProtKB/Swiss-Prot: TRI33_HUMAN, Q9UPN9
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM33: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRIM33

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRIM33 (Q9UPN91, 2, 3 ENSP000003512504) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157961, 3, ENSP000002621604EBI-2214398,EBI-1040141 I2D: score=2 STRING: ENSP00000262160
    SMAD3P840222, 3, ENSP000003329734MINT-8200333 I2D: score=1 STRING: ENSP00000332973
    ENSG00000235068Q018603, ENSP000004050414I2D: score=2 STRING: ENSP00000405041
    ENSG00000206454Q018603I2D: score=2 
    ENSG00000229094Q018603I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS--
    GO:0006351transcription, DNA-templated TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with TRIM33           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM33 (TRI33)

    4 HMDB Compounds for TRIM33    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRIM33 gene (2 alternative transcripts): 
    NM_015906.3  NM_033020.2  

    Unigene Cluster for TRIM33:

    Tripartite motif containing 33
    Hs.26837  [show with all ESTs]
    Unigene Representative Sequence: NM_015906
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358465(uc010owr.2 uc010ows.2 uc001eew.3 uc001eex.3)
    ENST00000492227 ENST00000478032 ENST00000448034 ENST00000369543 ENST00000476908(uc001eey.1)
    ENST00000450349
    miRNA
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    Block miRNA regulation of human, mouse, rat TRIM33 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM33 (see all 48):
    hsa-miR-429 hsa-miR-548k hsa-miR-371-5p hsa-miR-34b hsa-miR-520g hsa-miR-200b hsa-miR-192* hsa-miR-4273
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRIM33
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM33 (NM_015906)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM33
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    Addgene plasmids for TRIM33 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM33
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM33
      QuantiTect SYBR Green Assays in human, mouse, rat TRIM33
      QuantiFast Probe-based Assays in human, mouse, rat TRIM33

    Additional mRNA sequence: 

    AB029036.1 AB075517.1 AF119043.1 AF220136.1 AF220137.1 AJ132948.1 AK021491.1 AK023434.1 
    AK057487.1 AK301997.1 AL080216.1 

    22 DOTS entries:

    DT.115377  DT.440693  DT.100785184  DT.95275141  DT.85104409  DT.308745  DT.75102142  DT.423395 
    DT.95214939  DT.100785185  DT.40215810  DT.75197738  DT.314623  DT.95275138  DT.121389951  DT.85102592 
    DT.92437326  DT.95141057  DT.95165893  DT.95165904  DT.100660161  DT.100783399 

    Selected AceView cDNA sequences (see all 365):

    AU143484 AI214870 BU902983 BQ216999 BX090534 AA888070 BX501635 H23670 
    AA504332 AA630768 AB029036 AL080216 AL119641 AA633387 AA860281 CA441244 
    CA449409 AI244719 F05165 Z45140 AA653693 AA262843 AA827148 AL041260 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM33    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:        -                                                                                   -     -                 -                                       
    SP2:                                                                                                                                                        -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21a · 21b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for TRIM33

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM33 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTATTTAAT
    TRIM33 Expression
    About this image


    TRIM33 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord
    TRIM33 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM33 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.26837

    UniProtKB/Swiss-Prot: TRI33_HUMAN, Q9UPN9
    Tissue specificity: Expressed in stem cells at the bottom of the crypts of the colon (at protein level). Expressed
    in colon adenomas and adenocarcinomas (at protein level). Expressed in brain, lung, liver, spleen, thymus,
    prostate, kidney, testis, heart, placenta, pancreas, small intestine, ovary, colon, skeletal muscle and
    hematopoietic progenitors

        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM33: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRIM33 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim331 , 5 tripartite motif-containing 331, 5 91.25(n)1
    95.67(a)1
      3 (45.25 cM)5
    940931  NM_053170.31  NP_444400.21 
     1032792935 
    chicken
    (Gallus gallus)
    Aves TRIM331 tripartite motif containing 33 83.26(n)
    94.59(a)
      419883  XM_418009.4  XP_418009.4 
    lizard
    (Anolis carolinensis)
    Reptilia TRIM336
    tripartite motif containing 33
    93(a)
    1 ↔ 1
    4(130169301-130211392)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.328852 Xenopus laevis transcribed sequence with moderate similarity more 78.01(n)    BJ625867.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trim331 tripartite motif-containing 33 64.46(n)
    66.32(a)
      324053  NM_001002871.2  NP_001002871.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta bon3 peripheral nervous system development
    transcription more
    30(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea nhl-26
    Protein NHL-2 (nhl-2) mRNA, complete cds
    14(a)
    1 → many
    III(4894647-4899085) WBGene00003598


    ENSEMBL Gene Tree for TRIM33 (if available)
    TreeFam Gene Tree for TRIM33 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM33 gene
    TRIM662  TRIM242  AIRE2  TRIM282  
    4 SIMAP similar genes for TRIM33 using alignment to 3 protein entries:     TRI33_HUMAN (see all proteins):
    AIRE    SP110    TRIM24    BRDT

    Find genes that share paralogs with TRIM33           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM33 (see all 2297)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0423784
    A lung adenocarcinoma sample4--see VAR_0423782 E K mis40--------
    VAR_0423794
    A glioblastoma multiforme sample4--see VAR_0423792 P S mis40--------
    VAR_0423764
    A glioblastoma multiforme sample4--see VAR_0423762 M I mis40--------
    rs587641751,2
    C--112798776(+) TGTGT-/T/TT  
            
    TTTTT
    4 -- ut311NA 2
    rs1477178591,2
    C--112798779(+) GTTTT-/GTTTTT 2 -- ut310--------
    rs792842811,2
    C--112799210(+) AAAGGA/GAAATT 2 -- int10--------
    rs680702101,2
    C--112813246(+) ACCAA-/TCAA  
            
    AGAAA
    2 -- int11Minor allele frequency- TCAA:0.00NA 2
    rs2011028031,2
    C--112814746(+) AAAAA-/AGAAAGA 2 -- int10--------
    rs716648391,2
    C,F--112814750(+) AAAAAG/AAAAAG 2 -- int13Minor allele frequency- A:0.50NA WA 6
    rs768908561,2
    C--112814776(+) TTTCTG/CAAAAG 2 -- int11Minor allele frequency- C:0.50WA 2

    HapMap Linkage Disequilibrium report for TRIM33 (114935399 - 115053781 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TRIM33:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2474891CNV Deletion19546169
    esv2716485CNV Deletion23290073
    esv2102268CNV Deletion18987734
    esv28734CNV Loss19812545
    nsv831104CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605769   
    OMIM disorders: 188550  
    UniProtKB/Swiss-Prot: TRI33_HUMAN, Q9UPN9
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an
    irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm
    characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered
    with a surface layer of neoplastic epithelial cells. Note=The disease is caused by mutations affecting the gene
    represented in this entry. A chromosomal aberration involving TRIM33 is found in thyroid papillary carcinomas.
    Translocation t(1;10)(p13;q11) with RET. The translocation generates the TRIM33/RET (PTC7) oncogene

  • 2 diseases for TRIM33:    
    About MalaCards
    papillary thyroid carcinoma    follicular thyroid carcinoma


    Find genes that share disorders with TRIM33           About GenesLikeMe

    1 Novoseek inferred disease relationship for TRIM33 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 1.28 1 10741739 (1)

    Genetic Association Database (GAD): TRIM33

    Export disorders for TRIM33 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM33 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with TRIM33)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TIF1gamma, a novel member of the transcriptional intermediary factor 1 family. (PubMed id 10022127)1, 2, 3, 9 Venturini L....De The H. (Oncogene 1999)
    2. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2, 3 Reymond A.... Ballabio A. (EMBO J. 2001)
    3. FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. (PubMed id 19135894)1, 2 Dupont S.... Piccolo S. (Cell 2009)
    4. Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. (PubMed id 16751102)1, 2 He W....Massague J. (Cell 2006)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. (PubMed id 15820681)1, 2 Dupont S.... Piccolo S. (Cell 2005)
    7. Hetero-oligomerization among the TIF family of RBCC/TRIM domain- containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression. (PubMed id 12096914)1, 2 Peng H.... Rauscher F.J. III (J. Mol. Biol. 2002)
    8. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    9. The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas. (PubMed id 10439047)1, 2 Klugbauer S. and Rabes H.M. (Oncogene 1999)
    10. Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas. (PubMed id 19629168)1, 9 Vincent D.F....Bartholin L. (PLoS Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51592 HGNC: 16290 AceView: TRIM33 Ensembl:ENSG00000197323 euGenes: HUgn51592
    ECgene: TRIM33 H-InvDB: TRIM33

    (According to HUGE)
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    HUGE: KIAA1113

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRIM33 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRIM33 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM33 gene:
    Search GeneIP for patents involving TRIM33

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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