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Aliases for TRIM32 Gene

Aliases for TRIM32 Gene

  • Tripartite Motif Containing 32 2 3 5
  • Tripartite Motif-Containing Protein 32 3 4
  • Tripartite Motif-Containing 32 2 3
  • 72 KDa Tat-Interacting Protein 3 4
  • Zinc Finger Protein HT2A 3 4
  • HT2A 3 4
  • Limb Girdle Muscular Dystrophy 2H (Autosomal Recessive) 2
  • TAT-Interactive Protein, 72-KD 3
  • Zinc-Finger Protein HT2A 3
  • EC 6.3.2.- 4
  • LGMD2H 3
  • BBS11 3
  • TATIP 3

External Ids for TRIM32 Gene

Previous HGNC Symbols for TRIM32 Gene

  • LGMD2H

Previous GeneCards Identifiers for TRIM32 Gene

  • GC09P110277
  • GC09P111098
  • GC09P112903
  • GC09P114825
  • GC09P116529
  • GC09P118489
  • GC09P119449
  • GC09P089054

Summaries for TRIM32 Gene

Entrez Gene Summary for TRIM32 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM32 Gene

TRIM32 (Tripartite Motif Containing 32) is a Protein Coding gene. Diseases associated with TRIM32 include muscular dystrophy, limb-girdle, type 2h and bardet-biedl syndrome 11. Among its related pathways are Immune System and Cytosolic sensors of pathogen-associated DNA. GO annotations related to this gene include RNA binding and ubiquitin-protein transferase activity. An important paralog of this gene is NHLRC4.

UniProtKB/Swiss-Prot for TRIM32 Gene

  • Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.

Gene Wiki entry for TRIM32 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM32 Gene

Genomics for TRIM32 Gene

Regulatory Elements for TRIM32 Gene

Promoters for TRIM32 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM32 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM32 Gene

Chromosome:
9
Start:
116,687,302 bp from pter
End:
116,701,300 bp from pter
Size:
13,999 bases
Orientation:
Plus strand

Genomic View for TRIM32 Gene

Genes around TRIM32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM32 Gene

Proteins for TRIM32 Gene

  • Protein details for TRIM32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13049-TRI32_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM32
    Protein Accession:
    Q13049
    Secondary Accessions:
    • Q9NQP8

    Protein attributes for TRIM32 Gene

    Size:
    653 amino acids
    Molecular mass:
    71989 Da
    Quaternary structure:
    • Interacts with DTNBP1. It self-associates.

    Three dimensional structures from OCA and Proteopedia for TRIM32 Gene

neXtProt entry for TRIM32 Gene

Proteomics data for TRIM32 Gene at MOPED

Post-translational modifications for TRIM32 Gene

  • Ubiquitinated.
  • Ubiquitination at Lys 175, Lys 204, Lys 215, Lys 282, Lys 471, Lys 506, and Lys 627
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM32 Gene

Antibody Products

No data available for DME Specific Peptides for TRIM32 Gene

Domains & Families for TRIM32 Gene

Suggested Antigen Peptide Sequences for TRIM32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13049

UniProtKB/Swiss-Prot:

TRI32_HUMAN :
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 5 NHL repeats.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM32: view

Function for TRIM32 Gene

Molecular function for TRIM32 Gene

UniProtKB/Swiss-Prot Function:
Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.

Enzyme Numbers (IUBMB) for TRIM32 Gene

Gene Ontology (GO) - Molecular Function for TRIM32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
GO:0030957 Tat protein binding TAS 16175175
GO:0043621 protein self-association IDA 19349376
genes like me logo Genes that share ontologies with TRIM32: view
genes like me logo Genes that share phenotypes with TRIM32: view

Human Phenotype Ontology for TRIM32 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TRIM32 Gene

MGI Knock Outs for TRIM32:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRIM32

No data available for Transcription Factor Targets and HOMER Transcription for TRIM32 Gene

Localization for TRIM32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM32 Gene

Cytoplasm. Note=Localized in cytoplasmic bodies, often located around the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM32 Gene COMPARTMENTS Subcellular localization image for TRIM32 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 4
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for TRIM32 Gene

Pathways & Interactions for TRIM32 Gene

genes like me logo Genes that share pathways with TRIM32: view

UniProtKB/Swiss-Prot Q13049-TRI32_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001894 tissue homeostasis IEA --
GO:0007014 actin ubiquitination IEA --
GO:0009411 response to UV IEA,ISS --
GO:0016567 protein ubiquitination IEA,IDA 16816390
GO:0030307 positive regulation of cell growth IDA 18632609
genes like me logo Genes that share ontologies with TRIM32: view

No data available for SIGNOR curated interactions for TRIM32 Gene

Drugs & Compounds for TRIM32 Gene

(3) Drugs for TRIM32 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for TRIM32 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with TRIM32: view

Transcripts for TRIM32 Gene

Unigene Clusters for TRIM32 Gene

Tripartite motif containing 32:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM32 Gene

No ASD Table

Relevant External Links for TRIM32 Gene

GeneLoc Exon Structure for
TRIM32
ECgene alternative splicing isoforms for
TRIM32

Expression for TRIM32 Gene

mRNA expression in normal human tissues for TRIM32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRIM32 Gene

This gene is overexpressed in Breast (23.8), Lung (9.6), and Bone (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM32 Gene



SOURCE GeneReport for Unigene cluster for TRIM32 Gene Hs.591910

mRNA Expression by UniProt/SwissProt for TRIM32 Gene

Q13049-TRI32_HUMAN
Tissue specificity: Spleen, thymus, prostate, testis, ovary, intestine, colon and skeletal muscle.
genes like me logo Genes that share expression patterns with TRIM32: view

Protein tissue co-expression partners for TRIM32 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TRIM32 Gene

Orthologs for TRIM32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM32 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIM32 35
  • 85.96 (n)
  • 93.26 (a)
TRIM32 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM32 35
  • 91.04 (n)
  • 97.84 (a)
TRIM32 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim32 35
  • 87.99 (n)
  • 96.32 (a)
Trim32 16
Trim32 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIM32 35
  • 99.69 (n)
  • 99.85 (a)
TRIM32 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim32 35
  • 88.45 (n)
  • 96.93 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM32 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM32 35
  • 74.77 (n)
  • 83.72 (a)
lizard
(Anolis carolinensis)
Reptilia TRIM32 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim32 35
  • 66.72 (n)
  • 72.71 (a)
zebrafish
(Danio rerio)
Actinopterygii trim32 35
  • 63.89 (n)
  • 64.71 (a)
trim32 36
  • 63 (a)
OneToOne
Species with no ortholog for TRIM32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM32 Gene

ENSEMBL:
Gene Tree for TRIM32 (if available)
TreeFam:
Gene Tree for TRIM32 (if available)

Paralogs for TRIM32 Gene

Paralogs for TRIM32 Gene

(1) SIMAP similar genes for TRIM32 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TRIM32: view

Variants for TRIM32 Gene

Sequence variations from dbSNP and Humsavar for TRIM32 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_018725 Limb-girdle muscular dystrophy 2H (LGMD2H)
VAR_038807 Bardet-Biedl syndrome 11 (BBS11)
VAR_038808 -
VAR_038809 -
VAR_042939 Limb-girdle muscular dystrophy 2H (LGMD2H)

Structural Variations from Database of Genomic Variants (DGV) for TRIM32 Gene

Variant ID Type Subtype PubMed ID
nsv7434 OTHER Inversion 18451855
nsv831702 CNV Gain 17160897
nsv893776 CNV Loss 21882294
nsv893777 CNV Loss 21882294

Variation tolerance for TRIM32 Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM32 Gene

HapMap Linkage Disequilibrium report
TRIM32
Human Gene Mutation Database (HGMD)
TRIM32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM32 Gene

Disorders for TRIM32 Gene

MalaCards: The human disease database

(14) MalaCards diseases for TRIM32 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
muscular dystrophy, limb-girdle, type 2h
  • limb-girdle muscular dystrophy type 2h
bardet-biedl syndrome 11
  • bbs11
autosomal recessive limb-girdle muscular dystrophy type 2h
  • limb-girdle muscular dystrophy type 2h
bardet-biedl syndrome
  • laurence-moon syndrome
trim32-related bardet-biedl syndrome
  • bardet-biedl syndrome 11
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TRI32_HUMAN
  • Bardet-Biedl syndrome 11 (BBS11) [MIM:615988]: A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease. {ECO:0000269 PubMed:16606853}. Note=The disease is caused by mutations affecting the gene represented in this entry. It has been suggested that TRIM32 might be the E3 ubiquitin ligase for BBS2, a component of the BBSome complex involved in ciliogenesis, that is ubiquitinated and degraded by the proteasome (PubMed:22500027). {ECO:0000269 PubMed:22500027}.
  • Limb-girdle muscular dystrophy 2H (LGMD2H) [MIM:254110]: An autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life. {ECO:0000269 PubMed:11822024, ECO:0000269 PubMed:17994549}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TRIM32

Genetic Association Database (GAD)
TRIM32
Human Genome Epidemiology (HuGE) Navigator
TRIM32
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM32
genes like me logo Genes that share disorders with TRIM32: view

No data available for Genatlas for TRIM32 Gene

Publications for TRIM32 Gene

  1. Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins. (PMID: 7778269) Fridell R.A. … Cullen B.R. (Virology 1995) 2 3 4 23 67
  2. Use of SNP array analysis to identify a novel TRIM32 mutation in limb-girdle muscular dystrophy type 2H. (PMID: 19303295) CossAce M. … Mandel J.L. (Neuromuscul. Disord. 2009) 3 23
  3. Mutations that impair interaction properties of TRIM32 associated with limb-girdle muscular dystrophy 2H. (PMID: 17994549) Saccone V. … Nigro V. (Hum. Mutat. 2008) 3 23
  4. Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2. (PMID: 18632609) Kano S. … Hatakeyama S. (Cancer Res. 2008) 3 23
  5. Homozygosity mapping with SNP arrays identifies TRIM32, an E3 ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11). (PMID: 16606853) Chiang A.P. … Sheffield V.C. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3

Products for TRIM32 Gene

Sources for TRIM32 Gene

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