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Aliases for TRIM32 Gene

Aliases for TRIM32 Gene

  • Tripartite Motif Containing 32 2 3
  • HT2A 3 4 6
  • Tripartite Motif-Containing Protein 32 3 4
  • Tripartite Motif-Containing 32 2 3
  • 72 KDa Tat-Interacting Protein 3 4
  • Zinc Finger Protein HT2A 3 4
  • LGMD2H 3 6
  • BBS11 3 6
  • Limb Girdle Muscular Dystrophy 2H (Autosomal Recessive) 2
  • E3 Ubiquitin-Protein Ligase TRIM32 3
  • TAT-Interactive Protein, 72-KD 3
  • Zinc-Finger Protein HT2A 3
  • EC 6.3.2.- 4
  • TATIP 3

External Ids for TRIM32 Gene

Previous HGNC Symbols for TRIM32 Gene

  • LGMD2H

Previous GeneCards Identifiers for TRIM32 Gene

  • GC09P110277
  • GC09P111098
  • GC09P112903
  • GC09P114825
  • GC09P116529
  • GC09P118489
  • GC09P119449
  • GC09P089054

Summaries for TRIM32 Gene

Entrez Gene Summary for TRIM32 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM32 Gene

TRIM32 (Tripartite Motif Containing 32) is a Protein Coding gene. Diseases associated with TRIM32 include muscular dystrophy, limb-girdle, type 2h and bardet-biedl syndrome 11. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include RNA binding and transcription coactivator activity. An important paralog of this gene is NHLRC4.

UniProtKB/Swiss-Prot for TRIM32 Gene

  • Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.

Gene Wiki entry for TRIM32 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM32 Gene

Genomics for TRIM32 Gene

Regulatory Elements for TRIM32 Gene

Genomic Location for TRIM32 Gene

Start:
116,687,302 bp from pter
End:
116,701,300 bp from pter
Size:
13,999 bases
Orientation:
Plus strand

Genomic View for TRIM32 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM32 Gene

Proteins for TRIM32 Gene

  • Protein details for TRIM32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13049-TRI32_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM32
    Protein Accession:
    Q13049
    Secondary Accessions:
    • Q9NQP8

    Protein attributes for TRIM32 Gene

    Size:
    653 amino acids
    Molecular mass:
    71989 Da
    Quaternary structure:
    • Interacts with DTNBP1. It self-associates.

    Three dimensional structures from OCA and Proteopedia for TRIM32 Gene

neXtProt entry for TRIM32 Gene

Proteomics data for TRIM32 Gene at MOPED

Post-translational modifications for TRIM32 Gene

  • Ubiquitinated.
  • Ubiquitination at Lys175, Lys204, Lys215, Lys282, Lys471, Lys506, and Lys627
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM32 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TRIM32 Gene

Domains for TRIM32 Gene

Gene Families for TRIM32 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Suggested Antigen Peptide Sequences for TRIM32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13049

UniProtKB/Swiss-Prot:

TRI32_HUMAN :
  • Q13049
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 5 NHL repeats.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM32: view

Function for TRIM32 Gene

Molecular function for TRIM32 Gene

UniProtKB/Swiss-Prot Function: Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.

Enzyme Numbers (IUBMB) for TRIM32 Gene

Gene Ontology (GO) - Molecular Function for TRIM32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 7778269
GO:0003723 RNA binding ISS --
GO:0004842 ubiquitin-protein transferase activity IDA 19349376
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM32: view
genes like me logo Genes that share phenotypes with TRIM32: view

Animal Model Products

CRISPR Products

miRNA for TRIM32 Gene

miRTarBase miRNAs that target TRIM32

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIM32 Gene

Localization for TRIM32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM32 Gene

Cytoplasm. Note=Localized in cytoplasmic bodies, often located around the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM32 Gene COMPARTMENTS Subcellular localization image for TRIM32 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IDA 19349376
GO:0005829 cytosol TAS --
GO:0005863 colocalizes_with striated muscle myosin thick filament ISS --
genes like me logo Genes that share ontologies with TRIM32: view

Pathways for TRIM32 Gene

genes like me logo Genes that share pathways with TRIM32: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q13049-TRI32_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIM32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 18632609
GO:0009411 response to UV ISS --
GO:0016567 protein ubiquitination IDA 16816390
GO:0030307 positive regulation of cell growth IDA 18632609
GO:0030335 positive regulation of cell migration IDA 18632609
genes like me logo Genes that share ontologies with TRIM32: view

Compounds for TRIM32 Gene

(4) HMDB Compounds for TRIM32 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with TRIM32: view

Transcripts for TRIM32 Gene

Unigene Clusters for TRIM32 Gene

Tripartite motif containing 32:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM32

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM32 Gene

No ASD Table

Relevant External Links for TRIM32 Gene

GeneLoc Exon Structure for
TRIM32
ECgene alternative splicing isoforms for
TRIM32

Expression for TRIM32 Gene

mRNA expression in normal human tissues for TRIM32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM32 Gene

SOURCE GeneReport for Unigene cluster for TRIM32 Gene Hs.591910

mRNA Expression by UniProt/SwissProt for TRIM32 Gene

Q13049-TRI32_HUMAN
Tissue specificity: Spleen, thymus, prostate, testis, ovary, intestine, colon and skeletal muscle.
genes like me logo Genes that share expressions with TRIM32: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TRIM32 Gene

Orthologs for TRIM32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM32 35
  • 99.69 (n)
  • 99.85 (a)
TRIM32 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM32 35
  • 85.96 (n)
  • 93.26 (a)
TRIM32 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM32 35
  • 91.04 (n)
  • 97.84 (a)
TRIM32 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim32 35
  • 87.99 (n)
  • 96.32 (a)
Trim32 16
Trim32 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM32 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim32 35
  • 88.45 (n)
  • 96.93 (a)
chicken
(Gallus gallus)
Aves TRIM32 35
  • 74.77 (n)
  • 83.72 (a)
lizard
(Anolis carolinensis)
Reptilia TRIM32 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim32 35
  • 66.72 (n)
  • 72.71 (a)
zebrafish
(Danio rerio)
Actinopterygii trim32 35
  • 63.89 (n)
  • 64.71 (a)
trim32 36
  • 63 (a)
OneToOne
Species with no ortholog for TRIM32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM32 Gene

ENSEMBL:
Gene Tree for TRIM32 (if available)
TreeFam:
Gene Tree for TRIM32 (if available)

Paralogs for TRIM32 Gene

Paralogs for TRIM32 Gene

Selected SIMAP similar genes for TRIM32 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TRIM32: view

Variants for TRIM32 Gene

Sequence variations from dbSNP and Humsavar for TRIM32 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
VAR_018725 Limb-girdle muscular dystrophy 2H (LGMD2H)
VAR_038807 Bardet-Biedl syndrome 11 (BBS11)
VAR_038808 -
VAR_038809 -
VAR_042939 Limb-girdle muscular dystrophy 2H (LGMD2H)

Structural Variations from Database of Genomic Variants (DGV) for TRIM32 Gene

Variant ID Type Subtype PubMed ID
nsv7434 OTHER Inversion 18451855
nsv831702 CNV Gain 17160897
nsv893776 CNV Loss 21882294
nsv893777 CNV Loss 21882294

Relevant External Links for TRIM32 Gene

HapMap Linkage Disequilibrium report
TRIM32
Human Gene Mutation Database (HGMD)
TRIM32
Locus Specific Mutation Databases (LSDB)
TRIM32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM32 Gene

Disorders for TRIM32 Gene

(2) OMIM Diseases for TRIM32 Gene (602290)

UniProtKB/Swiss-Prot

TRI32_HUMAN
  • Limb-girdle muscular dystrophy 2H (LGMD2H) [MIM:254110]: An autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life. {ECO:0000269 PubMed:11822024, ECO:0000269 PubMed:17994549}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Bardet-Biedl syndrome 11 (BBS11) [MIM:615988]: A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease. {ECO:0000269 PubMed:16606853}. Note=The disease is caused by mutations affecting the gene represented in this entry. It has been suggested that TRIM32 might be the E3 ubiquitin ligase for BBS2, a component of the BBSome complex involved in ciliogenesis, that is ubiquitinated and degraded by the proteasome (PubMed:22500027). {ECO:0000269 PubMed:22500027}.

(2) University of Copenhagen DISEASES for TRIM32 Gene

(12) Novoseek inferred disease relationships for TRIM32 Gene

Disease -log(P) Hits PubMed IDs
lgmd2h 99.3 11
lgmd2g 97.3 3
lgmd2f 93.5 2
lgmd2i 93.4 2
lgmd2e 93.1 2

Relevant External Links for TRIM32

GeneTests
TRIM32
GeneReviews
TRIM32
Genetic Association Database (GAD)
TRIM32
Human Genome Epidemiology (HuGE) Navigator
TRIM32
genes like me logo Genes that share disorders with TRIM32: view

Publications for TRIM32 Gene

  1. Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins. (PMID: 7778269) Fridell R.A. … Cullen B.R. (Virology 1995) 2 3 4 23
  2. Limb-girdle muscular dystrophy type 2H associated with mutation in TRIM32, a putative E3-ubiquitin-ligase gene. (PMID: 11822024) Frosk P. … Wrogemann K. (Am. J. Hum. Genet. 2002) 3 4 23
  3. Mutations that impair interaction properties of TRIM32 associated with limb-girdle muscular dystrophy 2H. (PMID: 17994549) Saccone V. … Nigro V. (Hum. Mutat. 2008) 3 4 23
  4. Homozygosity mapping with SNP arrays identifies TRIM32, an E3 ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11). (PMID: 16606853) Chiang A.P. … Sheffield V.C. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3 4
  5. The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB. (PMID: 16816390) Albor A. … Kulesz-Martin M. (J. Biol. Chem. 2006) 3 23

Products for TRIM32 Gene

Sources for TRIM32 Gene

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