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Aliases for TRIM31 Gene

Aliases for TRIM31 Gene

  • Tripartite Motif Containing 31 2 3
  • Tripartite Motif-Containing Protein 31 3 4
  • C6orf13 3 4
  • RNF 3 4
  • Tripartite Motif-Containing 31 Gamma 3
  • Tripartite Motif-Containing 31 2
  • Ring Finger Protein 3
  • EC 6.3.2.- 4
  • HCG1 3
  • HCGI 3

External Ids for TRIM31 Gene

Previous GeneCards Identifiers for TRIM31 Gene

  • GC06M030155
  • GC06M029841
  • GC06M030176
  • GC06M030178
  • GC06M030073
  • GC06M029887
  • GC06M030129

Summaries for TRIM31 Gene

Entrez Gene Summary for TRIM31 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to both the cytoplasm and the nucleus. Its function has not been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM31 Gene

TRIM31 (Tripartite Motif Containing 31) is a Protein Coding gene. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include ligase activity. An important paralog of this gene is TRIM50.

UniProtKB/Swiss-Prot for TRIM31 Gene

  • Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity.

Gene Wiki entry for TRIM31 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM31 Gene

Genomics for TRIM31 Gene

Regulatory Elements for TRIM31 Gene

Genomic Location for TRIM31 Gene

Chromosome:
6
Start:
30,102,892 bp from pter
End:
30,113,106 bp from pter
Size:
10,215 bases
Orientation:
Minus strand

Genomic View for TRIM31 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TRIM31 Gene

  • Protein details for TRIM31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZY9-TRI31_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM31
    Protein Accession:
    Q9BZY9
    Secondary Accessions:
    • A6NLX6
    • A9R9Q4
    • Q53H52
    • Q5RI37
    • Q5SRJ7
    • Q5SRJ8
    • Q5SS28
    • Q96AK4
    • Q96AP8
    • Q99579
    • Q9BZY8

    Protein attributes for TRIM31 Gene

    Size:
    425 amino acids
    Molecular mass:
    48244 Da
    Quaternary structure:
    • Interacts with isoform p52shc of SHC1 (By similarity). May form oligomers.
    SequenceCaution:
    • Sequence=AAH16866.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM31 Gene

    Alternative splice isoforms for TRIM31 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM31 Gene

Proteomics data for TRIM31 Gene at MOPED

Post-translational modifications for TRIM31 Gene

Other Protein References for TRIM31 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM31 Gene

Domains & Families for TRIM31 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZY9

UniProtKB/Swiss-Prot:

TRI31_HUMAN :
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM31: view

Function for TRIM31 Gene

Molecular function for TRIM31 Gene

UniProtKB/Swiss-Prot Function:
Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity.

Enzyme Numbers (IUBMB) for TRIM31 Gene

Gene Ontology (GO) - Molecular Function for TRIM31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRIM31: view

Phenotypes for TRIM31 Gene

GenomeRNAi human phenotypes for TRIM31:
genes like me logo Genes that share phenotypes with TRIM31: view

Animal Model Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM31 Gene

Localization for TRIM31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM31 Gene

Cytoplasm. Mitochondrion. Note=Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria.

Gene Ontology (GO) - Cellular Components for TRIM31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRIM31: view

No data available for Subcellular locations from COMPARTMENTS for TRIM31 Gene

Pathways & Interactions for TRIM31 Gene

genes like me logo Genes that share pathways with TRIM31: view

Pathways by source for TRIM31 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9BZY9-TRI31_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIM31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0032897 negative regulation of viral transcription IDA 18248090
GO:0045087 innate immune response IMP 18248090
GO:0046597 negative regulation of viral entry into host cell IMP 18248090
genes like me logo Genes that share ontologies with TRIM31: view

No data available for SIGNOR curated interactions for TRIM31 Gene

Drugs & Compounds for TRIM31 Gene

No Compound Related Data Available

Transcripts for TRIM31 Gene

Unigene Clusters for TRIM31 Gene

Tripartite motif containing 31:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM31 Gene

No ASD Table

Relevant External Links for TRIM31 Gene

GeneLoc Exon Structure for
TRIM31
ECgene alternative splicing isoforms for
TRIM31

Expression for TRIM31 Gene

mRNA expression in normal human tissues for TRIM31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM31 Gene

This gene is overexpressed in Colon - Transverse (x23.0), Bladder (x9.6), Small Intestine - Terminal Ileum (x5.6), and Stomach (x4.3).

Protein differential expression in normal tissues from HIPED for TRIM31 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRIM31 Gene



SOURCE GeneReport for Unigene cluster for TRIM31 Gene Hs.493275

mRNA Expression by UniProt/SwissProt for TRIM31 Gene

Q9BZY9-TRI31_HUMAN
Tissue specificity: Up-regulated in gastric adenocarcinomas.
genes like me logo Genes that share expression patterns with TRIM31: view

Protein tissue co-expression partners for TRIM31 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for TRIM31 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM31 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIM31 35
  • 73.51 (n)
  • 62.72 (a)
TRIM31 36
  • 43 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim31 35
  • 70.04 (n)
  • 54.6 (a)
Trim31 16
Trim31 36
  • 38 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIM31 35
  • 99.14 (n)
  • 98.59 (a)
TRIM31 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim31 35
  • 67.37 (n)
  • 52.69 (a)
Species with no ortholog for TRIM31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM31 Gene

ENSEMBL:
Gene Tree for TRIM31 (if available)
TreeFam:
Gene Tree for TRIM31 (if available)

Paralogs for TRIM31 Gene

(11) SIMAP similar genes for TRIM31 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM31: view

Variants for TRIM31 Gene

Sequence variations from dbSNP and Humsavar for TRIM31 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1110446 -- 30,103,160(-) AATCC(A/G)GAGAG utr-variant-3-prime, nc-transcript-variant
rs2072109 -- 30,102,498(-) GCATC(C/G)AGCGG downstream-variant-500B
rs2072110 -- 30,102,401(-) CACAC(A/G)GCCCC downstream-variant-500B
rs2240071 -- 30,103,155(-) GGAGA(C/G)GAGCA utr-variant-3-prime, nc-transcript-variant
rs2523994 -- 30,102,569(-) GGCGG(G/T)GCCGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TRIM31 Gene

Variant ID Type Subtype PubMed ID
esv2731777 CNV Deletion 23290073
dgv6518n71 CNV Gain 21882294
nsv884055 CNV Loss 21882294

Variation tolerance for TRIM31 Gene

Residual Variation Intolerance Score: 92.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.41; 81.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM31 Gene

HapMap Linkage Disequilibrium report
TRIM31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM31 Gene

Disorders for TRIM31 Gene

Relevant External Links for TRIM31

Genetic Association Database (GAD)
TRIM31
Human Genome Epidemiology (HuGE) Navigator
TRIM31
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM31
genes like me logo Genes that share disorders with TRIM31: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM31 Gene

Publications for TRIM31 Gene

  1. Dimerization of hSiah proteins regulates their stability. (PMID: 16899216) Depaux A. … Varin-Blank N. (Biochem. Biophys. Res. Commun. 2006) 23 67
  2. Molecular characterization of ring finger protein 11. (PMID: 16123141) Connor M.K. … Seth A.K. (Mol. Cancer Res. 2005) 23 67
  3. DJ-1 restores p53 transcription activity inhibited by Topors/p53BP3. (PMID: 15703819) Shinbo Y. … Ariga H. (Int. J. Oncol. 2005) 23 67
  4. Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis. (PMID: 12947006) Davies F.E. … Anderson K.C. (Blood 2003) 23 67
  5. Molecular genetic analysis of cold-regulated gene transcription. (PMID: 12171651) Viswanathan C. … Zhu J.K. (Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2002) 23 67

Products for TRIM31 Gene

Sources for TRIM31 Gene

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