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Aliases for TRIM31 Gene

Aliases for TRIM31 Gene

  • Tripartite Motif Containing 31 2 3 5
  • Tripartite Motif-Containing Protein 31 3 4
  • Tripartite Motif-Containing 31 2 3
  • C6orf13 3 4
  • RNF 3 4
  • EC 6.3.2.- 4
  • HCG1 3
  • HCGI 3

External Ids for TRIM31 Gene

Previous GeneCards Identifiers for TRIM31 Gene

  • GC06M030155
  • GC06M029841
  • GC06M030176
  • GC06M030178
  • GC06M030073
  • GC06M029887
  • GC06M030129
  • GC06M030103

Summaries for TRIM31 Gene

Entrez Gene Summary for TRIM31 Gene

  • This gene encodes a protein that functions as an E3 ubiquitin-protein ligase. This gene shows altered expression in certain tumors and may be a negative regulator of cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for TRIM31 Gene

TRIM31 (Tripartite Motif Containing 31) is a Protein Coding gene. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include ligase activity. An important paralog of this gene is TRIM58.

UniProtKB/Swiss-Prot for TRIM31 Gene

  • Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity.

Gene Wiki entry for TRIM31 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM31 Gene

Genomics for TRIM31 Gene

Regulatory Elements for TRIM31 Gene

Enhancers for TRIM31 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM31 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM31 Gene

30,102,892 bp from pter
30,113,106 bp from pter
10,215 bases
Minus strand

Genomic View for TRIM31 Gene

Genes around TRIM31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TRIM31 Gene

  • Protein details for TRIM31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase TRIM31
    Protein Accession:
    Secondary Accessions:
    • A6NLX6
    • A9R9Q4
    • Q53H52
    • Q5RI37
    • Q5SRJ7
    • Q5SRJ8
    • Q5SS28
    • Q96AK4
    • Q96AP8
    • Q99579
    • Q9BZY8

    Protein attributes for TRIM31 Gene

    425 amino acids
    Molecular mass:
    48244 Da
    Quaternary structure:
    • Interacts with isoform p52shc of SHC1 (By similarity). May form oligomers.
    • Sequence=AAH16866.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM31 Gene

    Alternative splice isoforms for TRIM31 Gene


neXtProt entry for TRIM31 Gene

Proteomics data for TRIM31 Gene at MOPED

Post-translational modifications for TRIM31 Gene

Other Protein References for TRIM31 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM31 Gene

Domains & Families for TRIM31 Gene

Gene Families for TRIM31 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM31: view

Function for TRIM31 Gene

Molecular function for TRIM31 Gene

UniProtKB/Swiss-Prot Function:
Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity.

Enzyme Numbers (IUBMB) for TRIM31 Gene

Gene Ontology (GO) - Molecular Function for TRIM31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRIM31: view
genes like me logo Genes that share phenotypes with TRIM31: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TRIM31

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM31 Gene

Localization for TRIM31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM31 Gene

Cytoplasm. Mitochondrion. Note=Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria.

Subcellular locations from

Jensen Localization Image for TRIM31 Gene COMPARTMENTS Subcellular localization image for TRIM31 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for TRIM31 Gene

Pathways & Interactions for TRIM31 Gene

genes like me logo Genes that share pathways with TRIM31: view

Pathways by source for TRIM31 Gene

UniProtKB/Swiss-Prot Q9BZY9-TRI31_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response IEA,IMP 18248090
GO:0060333 interferon-gamma-mediated signaling pathway TAS --
GO:1902186 regulation of viral release from host cell IMP 18248090
genes like me logo Genes that share ontologies with TRIM31: view

No data available for SIGNOR curated interactions for TRIM31 Gene

Drugs & Compounds for TRIM31 Gene

No Compound Related Data Available

Transcripts for TRIM31 Gene

Unigene Clusters for TRIM31 Gene

Tripartite motif containing 31:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM31 Gene

No ASD Table

Relevant External Links for TRIM31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM31 Gene

mRNA expression in normal human tissues for TRIM31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM31 Gene

This gene is overexpressed in Colon - Transverse (x23.0), Bladder (x9.6), Small Intestine - Terminal Ileum (x5.6), and Stomach (x4.3).

Protein differential expression in normal tissues from HIPED for TRIM31 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM31 Gene

SOURCE GeneReport for Unigene cluster for TRIM31 Gene Hs.493275

mRNA Expression by UniProt/SwissProt for TRIM31 Gene

Tissue specificity: Up-regulated in gastric adenocarcinomas.
genes like me logo Genes that share expression patterns with TRIM31: view

Protein tissue co-expression partners for TRIM31 Gene

Primer Products

Orthologs for TRIM31 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM31 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIM31 35
  • 73.51 (n)
  • 62.72 (a)
TRIM31 36
  • 43 (a)
(Mus musculus)
Mammalia Trim31 35
  • 70.04 (n)
  • 54.6 (a)
Trim31 16
Trim31 36
  • 38 (a)
(Pan troglodytes)
Mammalia TRIM31 35
  • 99.14 (n)
  • 98.59 (a)
TRIM31 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Trim31 35
  • 67.37 (n)
  • 52.69 (a)
Species with no ortholog for TRIM31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM31 Gene

Gene Tree for TRIM31 (if available)
Gene Tree for TRIM31 (if available)

Paralogs for TRIM31 Gene

(11) SIMAP similar genes for TRIM31 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM31: view

Variants for TRIM31 Gene

Sequence variations from dbSNP and Humsavar for TRIM31 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_019962 -
VAR_022728 -
VAR_022729 -
VAR_052139 -
VAR_052140 -

Structural Variations from Database of Genomic Variants (DGV) for TRIM31 Gene

Variant ID Type Subtype PubMed ID
esv2731777 CNV Deletion 23290073
dgv6518n71 CNV Gain 21882294
nsv884055 CNV Loss 21882294

Variation tolerance for TRIM31 Gene

Residual Variation Intolerance Score: 92.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.41; 81.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRIM31 Gene

Disorders for TRIM31 Gene

Relevant External Links for TRIM31

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRIM31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM31 Gene

Publications for TRIM31 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3 4 67
  2. The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex. (PMID: 25590999) Kozakova L. … Palecek J.J. (Cell Cycle 2015) 3
  3. Genome-wide association study of proneness to anger. (PMID: 24489884) Mick E. … Goldberg R.J. (PLoS ONE 2014) 3
  4. TRIM31 is downregulated in non-small cell lung cancer and serves as a potential tumor suppressor. (PMID: 24566900) Li H. … He P. (Tumour Biol. 2014) 3
  5. A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. (PMID: 25217961) Al Olama A.A. … Haiman C.A. (Nat. Genet. 2014) 3

Products for TRIM31 Gene

Sources for TRIM31 Gene