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Aliases for TRIM31 Gene

Aliases for TRIM31 Gene

  • Tripartite Motif Containing 31 2 3
  • Tripartite Motif-Containing Protein 31 3 4
  • C6orf13 3 4
  • HCGI 3 6
  • RNF 3 4
  • Tripartite Motif-Containing 31 Gamma 3
  • E3 Ubiquitin-Protein Ligase TRIM31 3
  • Tripartite Motif-Containing 31 2
  • Ring Finger Protein 3
  • EC 6.3.2.- 4
  • HCG1 3

External Ids for TRIM31 Gene

Previous GeneCards Identifiers for TRIM31 Gene

  • GC06M030155
  • GC06M029841
  • GC06M030176
  • GC06M030178
  • GC06M030073
  • GC06M029887
  • GC06M030129

Summaries for TRIM31 Gene

Entrez Gene Summary for TRIM31 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to both the cytoplasm and the nucleus. Its function has not been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM31 Gene

TRIM31 (Tripartite Motif Containing 31) is a Protein Coding gene. Diseases associated with TRIM31 include lymphocytic choriomeningitis. GO annotations related to this gene include ligase activity. An important paralog of this gene is TRIM50.

UniProtKB/Swiss-Prot for TRIM31 Gene

  • Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity.

Gene Wiki entry for TRIM31 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM31 Gene

Genomics for TRIM31 Gene

Regulatory Elements for TRIM31 Gene

Genomic Location for TRIM31 Gene

30,102,897 bp from pter
30,113,106 bp from pter
10,210 bases
Minus strand

Genomic View for TRIM31 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TRIM31 Gene

  • Protein details for TRIM31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase TRIM31
    Protein Accession:
    Secondary Accessions:
    • A6NLX6
    • A9R9Q4
    • Q53H52
    • Q5RI37
    • Q5SRJ7
    • Q5SRJ8
    • Q5SS28
    • Q96AK4
    • Q96AP8
    • Q99579
    • Q9BZY8

    Protein attributes for TRIM31 Gene

    425 amino acids
    Molecular mass:
    48244 Da
    Quaternary structure:
    • Interacts with isoform p52shc of SHC1 (By similarity). May form oligomers.
    • Sequence=AAH16866.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM31 Gene

    Alternative splice isoforms for TRIM31 Gene


neXtProt entry for TRIM31 Gene

Proteomics data for TRIM31 Gene at MOPED

Post-translational modifications for TRIM31 Gene

Other Protein References for TRIM31 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TRIM31 Gene

Domains for TRIM31 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM31: view

Function for TRIM31 Gene

Molecular function for TRIM31 Gene

UniProtKB/Swiss-Prot Function:
Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity.

Enzyme Numbers (IUBMB) for TRIM31 Gene

Gene Ontology (GO) - Molecular Function for TRIM31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM31: view

Animal Model Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM31 Gene

Localization for TRIM31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM31 Gene

Cytoplasm. Mitochondrion. Note=Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria.

Subcellular locations from

Jensen Localization Image for TRIM31 Gene COMPARTMENTS Subcellular localization image for TRIM31 gene
Compartment Confidence
mitochondrion 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRIM31: view

Pathways for TRIM31 Gene

SuperPathways for TRIM31 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9BZY9-TRI31_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIM31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0032897 negative regulation of viral transcription IDA 18248090
GO:0045087 innate immune response IMP 18248090
GO:0046597 negative regulation of viral entry into host cell IMP 18248090
genes like me logo Genes that share ontologies with TRIM31: view

No data available for Pathways by source for TRIM31 Gene

Transcripts for TRIM31 Gene

Unigene Clusters for TRIM31 Gene

Tripartite motif containing 31:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM31 Gene

No ASD Table

Relevant External Links for TRIM31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM31 Gene

mRNA expression in normal human tissues for TRIM31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM31 Gene

This gene is overexpressed in Colon - Transverse (23.0), Bladder (9.6), Small Intestine - Terminal Ileum (5.6), and Stomach (4.3).

Protein differential expression in normal tissues for TRIM31 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TRIM31 Gene

SOURCE GeneReport for Unigene cluster for TRIM31 Gene Hs.493275

mRNA Expression by UniProt/SwissProt for TRIM31 Gene

Tissue specificity: Up-regulated in gastric adenocarcinomas.
genes like me logo Genes that share expressions with TRIM31: view

Expression partners for TRIM31 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for TRIM31 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM31 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIM31 35
  • 73.51 (n)
  • 62.72 (a)
TRIM31 36
  • 43 (a)
(Mus musculus)
Mammalia Trim31 35
  • 70.04 (n)
  • 54.6 (a)
Trim31 16
Trim31 36
  • 38 (a)
(Pan troglodytes)
Mammalia TRIM31 35
  • 99.14 (n)
  • 98.59 (a)
TRIM31 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Trim31 35
  • 67.37 (n)
  • 52.69 (a)
Species with no ortholog for TRIM31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM31 Gene

Gene Tree for TRIM31 (if available)
Gene Tree for TRIM31 (if available)

Paralogs for TRIM31 Gene

(11) SIMAP similar genes for TRIM31 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM31: view

Variants for TRIM31 Gene

Sequence variations from dbSNP and Humsavar for TRIM31 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1116222 -- 30,103,502(-) GTGCT(A/C)CACGG utr-variant-3-prime, nc-transcript-variant
rs2023472 -- 30,108,087(-) AGACA(C/T)GACTC synonymous-codon, reference, downstream-variant-500B, nc-transcript-variant
rs2239529 -- 30,110,553(+) TTCCC(C/T)GCTTC synonymous-codon, reference, nc-transcript-variant, upstream-variant-2KB
rs2248752 -- 30,108,329(+) tgagg(C/T)gggtg intron-variant
rs2517664 -- 30,105,482(-) CATTC(A/G)TGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM31 Gene

Variant ID Type Subtype PubMed ID
esv2731777 CNV Deletion 23290073
dgv6518n71 CNV Gain 21882294
nsv884055 CNV Loss 21882294

Relevant External Links for TRIM31 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM31 Gene

Disorders for TRIM31 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TRIM31 Gene in MalaCards »

(1) Disease for TRIM31 Gene

Relevant External Links for TRIM31

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TRIM31: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TRIM31 Gene

Publications for TRIM31 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 48

Products for TRIM31 Gene

Sources for TRIM31 Gene

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