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Aliases for TRIM3 Gene

Aliases for TRIM3 Gene

  • Tripartite Motif Containing 3 2 3
  • RNF22 3 4 6
  • BERP 3 4 6
  • Brain-Expressed RING Finger Protein 3 4
  • Tripartite Motif Protein TRIM3 2 3
  • Tripartite Motif-Containing 3 2 3
  • Brain Expressed Ring Finger 2 3
  • Ring Finger Protein 22 2 3
  • RING Finger Protein 97 3 4
  • RNF97 3 4
  • Tripartite Motif-Containing Protein 3 3
  • RING Finger Protein 22 4
  • HAC1 3

External Ids for TRIM3 Gene

Previous HGNC Symbols for TRIM3 Gene

  • RNF22

Previous GeneCards Identifiers for TRIM3 Gene

  • GC11M007213
  • GC11M006930
  • GC11M006428
  • GC11M006434
  • GC11M006426
  • GC11M006128

Summaries for TRIM3 Gene

Entrez Gene Summary for TRIM3 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM3 Gene

TRIM3 (Tripartite Motif Containing 3) is a Protein Coding gene. GO annotations related to this gene include protein C-terminus binding. An important paralog of this gene is TRIM71.

UniProtKB/Swiss-Prot for TRIM3 Gene

  • Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation

Gene Wiki entry for TRIM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM3 Gene

Genomics for TRIM3 Gene

Regulatory Elements for TRIM3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIM3 Gene

6,448,613 bp from pter
6,474,459 bp from pter
25,847 bases
Minus strand

Genomic View for TRIM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM3 Gene

Proteins for TRIM3 Gene

  • Protein details for TRIM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • B7Z5E6
    • F5H2Q8
    • Q4V9L4
    • Q9C038
    • Q9C039

    Protein attributes for TRIM3 Gene

    744 amino acids
    Molecular mass:
    80830 Da
    Quaternary structure:
    • Associates with myosin-Vb (MYO5B) and alpha-actinin-4 (ACTN4) (By similarity). Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts with ZFYVE28/LST2.

    Alternative splice isoforms for TRIM3 Gene


neXtProt entry for TRIM3 Gene

Proteomics data for TRIM3 Gene at MOPED

Post-translational modifications for TRIM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM3 Gene

Domains for TRIM3 Gene

Gene Families for TRIM3 Gene

  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Graphical View of Domain Structure for InterPro Entry



  • O75382
  • The interaction with MYO5B is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 filamin repeat.
  • Contains 6 NHL repeats.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM3: view

Function for TRIM3 Gene

Molecular function for TRIM3 Gene

UniProtKB/Swiss-Prot Function: Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation

Gene Ontology (GO) - Molecular Function for TRIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IPI 19460345
GO:0008022 protein C-terminus binding TAS 10391919
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM3: view
genes like me logo Genes that share phenotypes with TRIM3: view

Animal Models for TRIM3 Gene

MGI Knock Outs for TRIM3:

Animal Model Products

CRISPR Products

miRNA for TRIM3 Gene

miRTarBase miRNAs that target TRIM3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TRIM3 Gene

Localization for TRIM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM3 Gene

Cytoplasm. Early endosome.

Subcellular locations from

Jensen Localization Image for TRIM3 Gene COMPARTMENTS Subcellular localization image for TRIM3 gene
Compartment Confidence
endosome 5
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm TAS 10391919
GO:0005768 endosome --
GO:0005769 early endosome IEA --
genes like me logo Genes that share ontologies with TRIM3: view

Pathways for TRIM3 Gene

SuperPathways for TRIM3 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TRIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development TAS 10391919
GO:0015031 protein transport IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with TRIM3: view

No data available for Pathways by source for TRIM3 Gene

Transcripts for TRIM3 Gene

Unigene Clusters for TRIM3 Gene

Tripartite motif containing 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a ·
SP1: - - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: - - -
SP11: -

ExUns: 14b ^ 15a · 15b ^ 16
SP1: - -
SP2: - -

Relevant External Links for TRIM3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM3 Gene

mRNA expression in normal human tissues for TRIM3 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM3 Gene

This gene is overexpressed in Brain - Cerebellum (4.7) and Brain - Cerebellar Hemisphere (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRIM3 Gene

SOURCE GeneReport for Unigene cluster for TRIM3 Gene Hs.591992

mRNA Expression by UniProt/SwissProt for TRIM3 Gene

Tissue specificity: Expressed in brain, heart, uterus and testis
genes like me logo Genes that share expressions with TRIM3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TRIM3 Gene

Orthologs for TRIM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM3 35
  • 99.87 (n)
  • 100 (a)
TRIM3 36
  • 100 (a)
(Bos Taurus)
Mammalia TRIM3 35
  • 93.06 (n)
  • 99.19 (a)
TRIM3 36
  • 99 (a)
(Canis familiaris)
Mammalia TRIM3 35
  • 92.65 (n)
  • 99.06 (a)
TRIM3 36
  • 99 (a)
(Mus musculus)
Mammalia Trim3 35
  • 90.41 (n)
  • 98.66 (a)
Trim3 16
Trim3 36
  • 99 (a)
(Monodelphis domestica)
Mammalia TRIM3 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia TRIM3 36
  • 85 (a)
(Rattus norvegicus)
Mammalia Trim3 35
  • 90.59 (n)
  • 98.12 (a)
(Gallus gallus)
Aves TRIM3 35
  • 76.02 (n)
  • 79.62 (a)
TRIM3 36
  • 76 (a)
(Anolis carolinensis)
Reptilia TRIM3 36
  • 82 (a)
(Danio rerio)
Actinopterygii trim3a 36
  • 72 (a)
trim3b 35
  • 70.17 (n)
  • 76.55 (a)
trim3b 36
  • 73 (a)
fruit fly
(Drosophila melanogaster)
Insecta brat 36
  • 17 (a)
brat 37
  • 36 (a)
(Caenorhabditis elegans)
Secernentea ncl-1 36
  • 20 (a)
nhl-3 36
  • 23 (a)
ncl-1 37
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for TRIM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRIM3 Gene

Gene Tree for TRIM3 (if available)
Gene Tree for TRIM3 (if available)

Paralogs for TRIM3 Gene

Paralogs for TRIM3 Gene

genes like me logo Genes that share paralogs with TRIM3: view

Variants for TRIM3 Gene

Sequence variations from dbSNP and Humsavar for TRIM3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs10606 -- 6,456,601(-) CTTCC(A/G)GTGCC synonymous-codon, reference
rs1057364 -- 6,471,558(-) TGGCC(C/T)ACAGT intron-variant
rs1060067 -- 6,458,091(-) GCCCT(C/T)TCTCC reference, missense, utr-variant-5-prime
rs1060069 -- 6,456,787(-) CTGGG(C/G/T)GCACT reference, synonymous-codon
rs1060070 -- 6,456,687(-) TCACT(A/G)CCAAA reference, missense

Relevant External Links for TRIM3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TRIM3 Gene

Disorders for TRIM3 Gene

No disorders were found for TRIM3 Gene.

No data available for UniProtKB/Swiss-Prot for TRIM3 Gene

Publications for TRIM3 Gene

  1. Cloning and characterization of a gene (RNF22) encoding a novel brain expressed ring finger protein (BERP) that maps to human chromosome 11p15.5. (PMID: 11170753) El-Husseini A.E.-D. … Vincent S.R. (Genomics 2001) 3 4 23
  2. CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling. (PMID: 15772161) Yan Q. … Bean A.J. (Mol. Biol. Cell 2005) 3 4 23
  3. Loss of heterozygosity of TRIM3 in malignant gliomas. (PMID: 19250537) Boulay J.L. … Hirth F. (BMC Cancer 2009) 3 23
  4. Cloning and characterization of a novel RING finger protein that interacts with class V myosins. (PMID: 10391919) El-Husseini A.E. … Vincent S.R. (J. Biol. Chem. 1999) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for TRIM3 Gene

Sources for TRIM3 Gene

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