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Aliases for TRIM3 Gene

Aliases for TRIM3 Gene

  • Tripartite Motif Containing 3 2 3 5
  • Brain-Expressed RING Finger Protein 3 4
  • Tripartite Motif Protein TRIM3 2 3
  • Tripartite Motif-Containing 3 2 3
  • Brain Expressed Ring Finger 2 3
  • Ring Finger Protein 22 2 3
  • RING Finger Protein 97 3 4
  • RNF22 3 4
  • RNF97 3 4
  • BERP 3 4
  • RING Finger Protein 22 4
  • HAC1 3

External Ids for TRIM3 Gene

Previous HGNC Symbols for TRIM3 Gene

  • RNF22

Previous GeneCards Identifiers for TRIM3 Gene

  • GC11M007213
  • GC11M006930
  • GC11M006428
  • GC11M006434
  • GC11M006426
  • GC11M006128

Summaries for TRIM3 Gene

Entrez Gene Summary for TRIM3 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM3 Gene

TRIM3 (Tripartite Motif Containing 3) is a Protein Coding gene. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include ubiquitin-protein transferase activity and protein C-terminus binding. An important paralog of this gene is NHLRC4.

UniProtKB/Swiss-Prot for TRIM3 Gene

  • Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation.

Gene Wiki entry for TRIM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM3 Gene

Genomics for TRIM3 Gene

Regulatory Elements for TRIM3 Gene

Promoters for TRIM3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM3 Gene

Chromosome:
11
Start:
6,448,613 bp from pter
End:
6,474,459 bp from pter
Size:
25,847 bases
Orientation:
Minus strand

Genomic View for TRIM3 Gene

Genes around TRIM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM3 Gene

Proteins for TRIM3 Gene

  • Protein details for TRIM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75382-TRIM3_HUMAN
    Recommended name:
    Tripartite motif-containing protein 3
    Protein Accession:
    O75382
    Secondary Accessions:
    • B7Z5E6
    • F5H2Q8
    • Q4V9L4
    • Q9C038
    • Q9C039

    Protein attributes for TRIM3 Gene

    Size:
    744 amino acids
    Molecular mass:
    80830 Da
    Quaternary structure:
    • Associates with myosin-Vb (MYO5B) and alpha-actinin-4 (ACTN4) (By similarity). Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts with ZFYVE28/LST2.

    Alternative splice isoforms for TRIM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM3 Gene

Proteomics data for TRIM3 Gene at MOPED

Post-translational modifications for TRIM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for TRIM3 Gene

Domains & Families for TRIM3 Gene

Gene Families for TRIM3 Gene

Graphical View of Domain Structure for InterPro Entry

O75382

UniProtKB/Swiss-Prot:

TRIM3_HUMAN :
  • The interaction with MYO5B is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Domain:
  • The interaction with MYO5B is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 filamin repeat.
  • Contains 6 NHL repeats.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM3: view

Function for TRIM3 Gene

Molecular function for TRIM3 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation.

Gene Ontology (GO) - Molecular Function for TRIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 19460345
GO:0008022 protein C-terminus binding TAS 10391919
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM3: view
genes like me logo Genes that share phenotypes with TRIM3: view

Animal Models for TRIM3 Gene

MGI Knock Outs for TRIM3:

Animal Model Products

miRNA for TRIM3 Gene

miRTarBase miRNAs that target TRIM3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM3 Gene

Localization for TRIM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM3 Gene

Cytoplasm. Early endosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM3 Gene COMPARTMENTS Subcellular localization image for TRIM3 gene
Compartment Confidence
nucleus 4
endosome 3
mitochondrion 3
cytosol 2
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for TRIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
genes like me logo Genes that share ontologies with TRIM3: view

Pathways & Interactions for TRIM3 Gene

genes like me logo Genes that share pathways with TRIM3: view

Pathways by source for TRIM3 Gene

Gene Ontology (GO) - Biological Process for TRIM3 Gene

None

No data available for SIGNOR curated interactions for TRIM3 Gene

Drugs & Compounds for TRIM3 Gene

No Compound Related Data Available

Transcripts for TRIM3 Gene

Unigene Clusters for TRIM3 Gene

Tripartite motif containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a ·
SP1: - - - - - - - -
SP2:
SP3: - - - -
SP4: - -
SP5: - - - - -
SP6:
SP7: - - - - -
SP8: - - - - - - -
SP9: - - -
SP10:
SP11: -
SP12:
SP13:

ExUns: 14b ^ 15a · 15b ^ 16
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for TRIM3 Gene

GeneLoc Exon Structure for
TRIM3
ECgene alternative splicing isoforms for
TRIM3

Expression for TRIM3 Gene

mRNA expression in normal human tissues for TRIM3 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM3 Gene

This gene is overexpressed in Brain - Cerebellum (x4.7) and Brain - Cerebellar Hemisphere (x4.6).

Protein differential expression in normal tissues from HIPED for TRIM3 Gene

This gene is overexpressed in Fetal Brain (20.5), Lung (14.6), and Spinal cord (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM3 Gene



SOURCE GeneReport for Unigene cluster for TRIM3 Gene Hs.591992

mRNA Expression by UniProt/SwissProt for TRIM3 Gene

O75382-TRIM3_HUMAN
Tissue specificity: Expressed in brain, heart, uterus and testis.
genes like me logo Genes that share expression patterns with TRIM3: view

Protein tissue co-expression partners for TRIM3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TRIM3 Gene

Orthologs for TRIM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIM3 35
  • 93.06 (n)
  • 99.19 (a)
TRIM3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM3 35
  • 92.65 (n)
  • 99.06 (a)
TRIM3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim3 35
  • 90.41 (n)
  • 98.66 (a)
Trim3 16
Trim3 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIM3 35
  • 99.87 (n)
  • 100 (a)
TRIM3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim3 35
  • 90.59 (n)
  • 98.12 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIM3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM3 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM3 35
  • 76.02 (n)
  • 79.62 (a)
TRIM3 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM3 36
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii trim3b 35
  • 70.17 (n)
  • 76.55 (a)
trim3a 36
  • 72 (a)
OneToMany
trim3b 36
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta brat 37
  • 36 (a)
brat 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ncl-1 37
  • 36 (a)
ncl-1 36
  • 20 (a)
ManyToMany
nhl-3 36
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for TRIM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRIM3 Gene

ENSEMBL:
Gene Tree for TRIM3 (if available)
TreeFam:
Gene Tree for TRIM3 (if available)

Paralogs for TRIM3 Gene

Paralogs for TRIM3 Gene

genes like me logo Genes that share paralogs with TRIM3: view

Variants for TRIM3 Gene

Sequence variations from dbSNP and Humsavar for TRIM3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10128723 - 6,456,833(+) GGACC(A/C)GTTCC reference, missense
rs10606 -- 6,456,601(-) CTTCC(A/G)GTGCC reference, synonymous-codon
rs1137113 -- 6,465,638(-) AGTTC(C/T)TGGTA intron-variant, reference, synonymous-codon, utr-variant-5-prime
rs1137114 -- 6,457,019(-) GCAAA(C/G)CCAGC reference, missense
rs1057364 -- 6,471,558(-) TGGCC(C/T)ACAGT intron-variant

Variation tolerance for TRIM3 Gene

Residual Variation Intolerance Score: 7.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM3 Gene

HapMap Linkage Disequilibrium report
TRIM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TRIM3 Gene

Disorders for TRIM3 Gene

Relevant External Links for TRIM3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM3

No disorders were found for TRIM3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM3 Gene

Publications for TRIM3 Gene

  1. Cloning and characterization of a gene (RNF22) encoding a novel brain expressed ring finger protein (BERP) that maps to human chromosome 11p15.5. (PMID: 11170753) El-Husseini A.E.-D. … Vincent S.R. (Genomics 2001) 3 4 23 67
  2. Loss of heterozygosity of TRIM3 in malignant gliomas. (PMID: 19250537) Boulay J.L. … Hirth F. (BMC Cancer 2009) 3 23
  3. CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling. (PMID: 15772161) Yan Q. … Bean A.J. (Mol. Biol. Cell 2005) 3 23
  4. Cloning and characterization of a novel RING finger protein that interacts with class V myosins. (PMID: 10391919) El-Husseini A.E. … Vincent S.R. (J. Biol. Chem. 1999) 2 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for TRIM3 Gene

Sources for TRIM3 Gene

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