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Aliases for TRIM29 Gene

Aliases for TRIM29 Gene

  • Tripartite Motif Containing 29 2 3
  • Ataxia-Telangiectasia Group D-Associated Protein 2 3
  • Ataxia Telangiectasia Group D-Associated Protein 3 4
  • Tripartite Motif Protein TRIM29 2 3
  • Tripartite Motif-Containing 29 2 3
  • ATDC 3 4
  • Tripartite Motif-Containing Protein 29 3

External Ids for TRIM29 Gene

Summaries for TRIM29 Gene

Entrez Gene Summary for TRIM29 Gene

  • The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM29 Gene

TRIM29 (Tripartite Motif Containing 29) is a Protein Coding gene. Diseases associated with TRIM29 include ataxia. Among its related pathways are Cell Cycle / Checkpoint Control. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and p53 binding. An important paralog of this gene is TRIM16L.

UniProtKB/Swiss-Prot for TRIM29 Gene

  • It is able to complement the radiosensitivity defect of an ataxia telangiectasia (AT) fibroblast cell line

Gene Wiki entry for TRIM29 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM29 Gene

Genomics for TRIM29 Gene

Genomic Location for TRIM29 Gene

Start:
120,111,275 bp from pter
End:
120,185,529 bp from pter
Size:
74,255 bases
Orientation:
Minus strand

Genomic View for TRIM29 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM29 Gene

Regulatory Elements for TRIM29 Gene

Proteins for TRIM29 Gene

  • Protein details for TRIM29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14134-TRI29_HUMAN
    Recommended name:
    Tripartite motif-containing protein 29
    Protein Accession:
    Q14134
    Secondary Accessions:
    • Q96AA9
    • Q9BZY7

    Protein attributes for TRIM29 Gene

    Size:
    588 amino acids
    Molecular mass:
    65835 Da
    Quaternary structure:
    • Interacts with VIM and HINT1.

    Three dimensional structures from OCA and Proteopedia for TRIM29 Gene

    Alternative splice isoforms for TRIM29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM29 Gene

Proteomics data for TRIM29 Gene at MOPED

Post-translational modifications for TRIM29 Gene

  • Constitutively phosphorylated by PKC on serine/threonine in A431 cells.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM29 Gene

Domains for TRIM29 Gene

Gene Families for TRIM29 Gene

HGNC:
  • TRIM :Tripartite motif containing / Tripartite motif containing

Protein Domains for TRIM29 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TRI29_HUMAN
Similarity:
  • Contains 1 B box-type zinc finger.:
    • Q14134
genes like me logo Genes that share domains with TRIM29: view

Function for TRIM29 Gene

Molecular function for TRIM29 Gene

UniProtKB/Swiss-Prot Function: It is able to complement the radiosensitivity defect of an ataxia telangiectasia (AT) fibroblast cell line

Gene Ontology (GO) - Molecular Function for TRIM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 8188213
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM29: view

miRNA for TRIM29 Gene

miRTarBase miRNAs that target TRIM29

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIM29 Gene

Localization for TRIM29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM29 Gene

Cytoplasm. Note=Colocalizes with intermediate filaments.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM29 Gene COMPARTMENTS Subcellular localization image for TRIM29 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TRIM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with TRIM29: view

Pathways for TRIM29 Gene

SuperPathways for TRIM29 Gene

Superpath Contained pathways
1 Cell Cycle / Checkpoint Control
genes like me logo Genes that share pathways with TRIM29: view

Pathways by source for TRIM29 Gene

1 Cell Signaling Technology pathway for TRIM29 Gene

Gene Ontology (GO) - Biological Process for TRIM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 8188213
GO:1900181 negative regulation of protein localization to nucleus IEA --
genes like me logo Genes that share ontologies with TRIM29: view

Transcripts for TRIM29 Gene

Unigene Clusters for TRIM29 Gene

Tripartite motif containing 29:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM29 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: -
SP9: - - -
SP10: - -
SP11: - - -
SP12: - -
SP13: - -
SP14:
SP15: -

ExUns: 18c · 18d · 18e · 18f · 18g ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - - -
SP14:
SP15:

Relevant External Links for TRIM29 Gene

GeneLoc Exon Structure for
TRIM29
ECgene alternative splicing isoforms for
TRIM29

Expression for TRIM29 Gene

mRNA expression in normal human tissues for TRIM29 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM29 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (13.2), Esophagus - Mucosa (12.8), Skin - Not Sun Exposed (Suprapubic) (11.4), and Vagina (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM29 Gene

SOURCE GeneReport for Unigene cluster for TRIM29 Gene Hs.504115

mRNA Expression by UniProt/SwissProt for TRIM29 Gene

Q14134-TRI29_HUMAN
Tissue specificity: Expressed in placenta, prostate and thymus.
genes like me logo Genes that share expressions with TRIM29: view

Orthologs for TRIM29 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM29 36
  • 99.49 (n)
  • 99.32 (a)
TRIM29 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM29 36
  • 88.93 (n)
  • 88.87 (a)
TRIM29 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM29 36
  • 89.61 (n)
  • 89.95 (a)
TRIM29 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim29 36
  • 86.71 (n)
  • 89.61 (a)
Trim29 16
Trim29 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM29 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM29 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim29 36
  • 86.43 (n)
  • 90.8 (a)
chicken
(Gallus gallus)
Aves TRIM29 36
  • 67.73 (n)
  • 64.77 (a)
TRIM29 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM29 37
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53484 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3257 36
trim29 36
  • 59.13 (n)
  • 49.88 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01034857.1 37
  • 28 (a)
OneToMany
CABZ01034858.1 37
  • 29 (a)
OneToMany
CR352329.1 37
  • 21 (a)
OneToMany
ftr01 37
  • 22 (a)
OneToMany
ftr02 37
  • 21 (a)
OneToMany
ftr03 37
  • 26 (a)
OneToMany
ftr04 37
  • 25 (a)
OneToMany
ftr05 37
  • 27 (a)
OneToMany
ftr06 37
  • 24 (a)
OneToMany
ftr07 37
  • 21 (a)
OneToMany
ftr08 37
  • 26 (a)
OneToMany
ftr09 37
  • 26 (a)
OneToMany
ftr10 37
  • 28 (a)
OneToMany
ftr11 37
  • 20 (a)
OneToMany
ftr12 37
  • 21 (a)
OneToMany
ftr13 37
  • 23 (a)
OneToMany
ftr14 37
  • 21 (a)
OneToMany
ftr14l 37
  • 22 (a)
OneToMany
ftr15 37
  • 24 (a)
OneToMany
ftr16 37
  • 20 (a)
OneToMany
ftr19 37
  • 29 (a)
OneToMany
ftr19 37
  • 29 (a)
OneToMany
ftr22 37
  • 22 (a)
OneToMany
ftr23 37
  • 21 (a)
OneToMany
ftr24 37
  • 21 (a)
OneToMany
ftr26 37
  • 26 (a)
OneToMany
ftr26 37
  • 24 (a)
OneToMany
ftr27 37
  • 27 (a)
OneToMany
ftr28l 37
  • 25 (a)
OneToMany
ftr29 37
  • 21 (a)
OneToMany
ftr30 37
  • 21 (a)
OneToMany
ftr32 37
  • 16 (a)
OneToMany
ftr33 37
  • 21 (a)
OneToMany
ftr34 37
  • 21 (a)
OneToMany
ftr35 37
  • 22 (a)
OneToMany
ftr36 37
  • 21 (a)
OneToMany
ftr37 37
  • 20 (a)
OneToMany
ftr38 37
  • 22 (a)
OneToMany
ftr41 37
  • 20 (a)
OneToMany
ftr42 37
  • 20 (a)
OneToMany
ftr43 37
  • 20 (a)
OneToMany
ftr46 37
  • 25 (a)
OneToMany
ftr50 37
  • 23 (a)
OneToMany
ftr51 37
  • 21 (a)
OneToMany
ftr53 37
  • 20 (a)
OneToMany
ftr54 37
  • 17 (a)
OneToMany
ftr55 37
  • 18 (a)
OneToMany
ftr56 37
  • 20 (a)
OneToMany
ftr57 37
  • 19 (a)
OneToMany
ftr58 37
  • 20 (a)
OneToMany
ftr59 37
  • 19 (a)
OneToMany
ftr61 37
  • 22 (a)
OneToMany
ftr64 37
  • 22 (a)
OneToMany
ftr65 37
  • 21 (a)
OneToMany
ftr66 37
  • 20 (a)
OneToMany
ftr67 37
  • 24 (a)
OneToMany
ftr69 37
  • 25 (a)
OneToMany
ftr72 37
  • 21 (a)
OneToMany
ftr73 37
  • 20 (a)
OneToMany
ftr76 37
  • 19 (a)
OneToMany
ftr79 37
  • 17 (a)
OneToMany
ftr82 37
  • 21 (a)
OneToMany
ftr83 37
  • 20 (a)
OneToMany
TRIM29 (14 of 87) 37
  • 14 (a)
OneToMany
TRIM29 (15 of 87) 37
  • 18 (a)
OneToMany
TRIM29 (16 of 87) 37
  • 20 (a)
OneToMany
TRIM29 (18 of 87) 37
  • 19 (a)
OneToMany
TRIM29 (19 of 87) 37
  • 19 (a)
OneToMany
TRIM29 (20 of 87) 37
  • 22 (a)
OneToMany
TRIM29 (31 of 87) 37
  • 14 (a)
OneToMany
TRIM29 (35 of 87) 37
  • 17 (a)
OneToMany
TRIM29 (36 of 87) 37
  • 24 (a)
OneToMany
TRIM29 (38 of 87) 37
  • 30 (a)
OneToMany
TRIM29 (41 of 87) 37
  • 18 (a)
OneToMany
TRIM29 (42 of 87) 37
  • 20 (a)
OneToMany
TRIM29 (44 of 87) 37
  • 21 (a)
OneToMany
TRIM29 (5 of 87) 37
  • 17 (a)
OneToMany
TRIM29 (50 of 87) 37
  • 24 (a)
OneToMany
TRIM29 (55 of 87) 37
  • 29 (a)
OneToMany
TRIM29 (61 of 87) 37
  • 24 (a)
OneToMany
TRIM29 (63 of 87) 37
  • 18 (a)
OneToMany
TRIM29 (71 of 87) 37
  • 27 (a)
OneToMany
TRIM29 (82 of 87) 37
  • 13 (a)
OneToMany
TRIM29 (84 of 87) 37
  • 22 (a)
OneToMany
TRIM29 (85 of 87) 37
  • 20 (a)
OneToMany
TRIM29 (86 of 87) 37
  • 24 (a)
OneToMany
TRIM29 (87 of 87) 37
  • 21 (a)
OneToMany
Species with no ortholog for TRIM29:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM29 Gene

ENSEMBL:
Gene Tree for TRIM29 (if available)
TreeFam:
Gene Tree for TRIM29 (if available)

Paralogs for TRIM29 Gene

Paralogs for TRIM29 Gene

genes like me logo Genes that share paralogs with TRIM29: view

Variants for TRIM29 Gene

Sequence variations from dbSNP and Humsavar for TRIM29 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs470392 -- 120,123,713(-) AAGAC(A/G)GGGAA intron-variant
rs470645 -- 120,137,181(-) TCTCA(A/C)CCCAC intron-variant
rs470725 -- 120,126,891(-) ACTCT(A/G)TTAGG intron-variant
rs470941 -- 120,129,047(-) AGAAT(A/G)CCTTC intron-variant, upstream-variant-2KB
rs477337 -- 120,130,177(-) GCCAA(A/G)TCCAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIM29 Gene

Variant ID Type Subtype PubMed ID
esv2673699 CNV Deletion 23128226
esv2745143 CNV Deletion 23290073

Relevant External Links for TRIM29 Gene

HapMap Linkage Disequilibrium report
TRIM29

Disorders for TRIM29 Gene

(1) MalaCards Diseases for TRIM29 Gene

Search for TRIM29 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TRIM29 Gene

Relevant External Links for TRIM29

Genetic Association Database (GAD)
TRIM29
Human Genome Epidemiology (HuGE) Navigator
TRIM29
genes like me logo Genes that share disorders with TRIM29: view

No data available for UniProtKB/Swiss-Prot for TRIM29 Gene

Publications for TRIM29 Gene

  1. Expression of the ATDC (ataxia telangiectasia group D-complementing) gene in A431 human squamous carcinoma cells. (PMID: 8647648) Laderoute K.R. … Kapp L.N. (Int. J. Cancer 1996) 3 4 23
  2. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3 4
  3. Nucleotide sequence analysis of a candidate gene for ataxia- telangiectasia group D (ATDC). (PMID: 8188213) Leonhardt E.A. … Murnane J.P. (Genomics 1994) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC. (PMID: 16890201) Hosoi Y. … Miyagawa K. (Biochem. Biophys. Res. Commun. 2006) 3 23

Products for TRIM29 Gene

Sources for TRIM29 Gene

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