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Aliases for TRIM29 Gene

Aliases for TRIM29 Gene

  • Tripartite Motif Containing 29 2 3 5
  • Ataxia-Telangiectasia Group D-Associated Protein 2 3
  • Tripartite Motif Protein TRIM29 2 3
  • ATDC 3 4
  • Ataxia Telangiectasia Group D-Associated Protein 4
  • Tripartite Motif-Containing Protein 29 3
  • Tripartite Motif-Containing 29 2

External Ids for TRIM29 Gene

Previous GeneCards Identifiers for TRIM29 Gene

  • GC11M121981
  • GC11M121493
  • GC11M120015
  • GC11M119520
  • GC11M119521
  • GC11M119487
  • GC11M115921
  • GC11M119981

Summaries for TRIM29 Gene

Entrez Gene Summary for TRIM29 Gene

  • The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM29 Gene

TRIM29 (Tripartite Motif Containing 29) is a Protein Coding gene. Diseases associated with TRIM29 include Ataxia-Telangiectasia. Among its related pathways are Interferon gamma signaling and Immune System. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and p53 binding. An important paralog of this gene is TRIM16.

UniProtKB/Swiss-Prot for TRIM29 Gene

  • It is able to complement the radiosensitivity defect of an ataxia telangiectasia (AT) fibroblast cell line.

Gene Wiki entry for TRIM29 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM29 Gene

Genomics for TRIM29 Gene

Regulatory Elements for TRIM29 Gene

Enhancers for TRIM29 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F120131 1.1 Ensembl ENCODE 38.3 +50.2 50245 7.8 CTCF PKNOX1 SCRT2 REST KDM6A TRIM29 RNU6-1123P ENSG00000255216 OAF LOC105369529 LOC729173
GH11F120128 1.2 Ensembl ENCODE 38.2 +56.4 56443 3.2 GTF2F1 TBP CTCF MXI1 JUN MAX RAD21 BRCA1 RFX5 ZBTB48 TRIM29 OAF LOC105369529 LOC729173
GH11F120207 0.9 FANTOM5 ENCODE 20.2 -25.6 -25640 6.9 CREB3L1 SIN3A ARID4B DMAP1 YY1 GLIS2 SP3 SP5 MIER2 REST POU2F3 TRIM29 LOC729173 OAF ARHGEF12 GRIK4
GH11F120217 0.6 Ensembl ENCODE 16.6 -34.4 -34392 4.8 SOX13 ELF3 SAP130 ARID4B RAD21 ZIC2 RARA YY1 ZNF664 NR2F6 POU2F3 TRIM29 LOC729173 TMEM136 OAF
GH11F120119 0.9 Ensembl ENCODE 14.4 +62.6 62574 6.3 ELF3 CBX3 PKNOX1 KLF17 RAD21 RCOR1 FOS EGR2 SMARCC1 CEBPB TRIM29 OAF GRIK4 LOC105369529 LOC105378956
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TRIM29 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM29 Gene

Chromosome:
11
Start:
120,111,275 bp from pter
End:
120,185,529 bp from pter
Size:
74,255 bases
Orientation:
Minus strand

Genomic View for TRIM29 Gene

Genes around TRIM29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM29 Gene

Proteins for TRIM29 Gene

  • Protein details for TRIM29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14134-TRI29_HUMAN
    Recommended name:
    Tripartite motif-containing protein 29
    Protein Accession:
    Q14134
    Secondary Accessions:
    • Q96AA9
    • Q9BZY7

    Protein attributes for TRIM29 Gene

    Size:
    588 amino acids
    Molecular mass:
    65835 Da
    Quaternary structure:
    • Interacts with VIM and HINT1.

    Three dimensional structures from OCA and Proteopedia for TRIM29 Gene

    Alternative splice isoforms for TRIM29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM29 Gene

Post-translational modifications for TRIM29 Gene

  • Constitutively phosphorylated by PKC on serine/threonine in A431 cells.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TRIM29 (TRIM29)

No data available for DME Specific Peptides for TRIM29 Gene

Domains & Families for TRIM29 Gene

Gene Families for TRIM29 Gene

Protein Domains for TRIM29 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q14134

UniProtKB/Swiss-Prot:

TRI29_HUMAN :
  • Contains 1 B box-type zinc finger.
Similarity:
  • Contains 1 B box-type zinc finger.
genes like me logo Genes that share domains with TRIM29: view

Function for TRIM29 Gene

Molecular function for TRIM29 Gene

UniProtKB/Swiss-Prot Function:
It is able to complement the radiosensitivity defect of an ataxia telangiectasia (AT) fibroblast cell line.

Gene Ontology (GO) - Molecular Function for TRIM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 8188213
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM29: view
genes like me logo Genes that share phenotypes with TRIM29: view

Animal Models for TRIM29 Gene

MGI Knock Outs for TRIM29:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM29 Gene

Localization for TRIM29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM29 Gene

Cytoplasm. Note=Colocalizes with intermediate filaments.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM29 Gene COMPARTMENTS Subcellular localization image for TRIM29 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for TRIM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with TRIM29: view

Pathways & Interactions for TRIM29 Gene

genes like me logo Genes that share pathways with TRIM29: view

Pathways by source for TRIM29 Gene

1 Cell Signaling Technology pathway for TRIM29 Gene

Gene Ontology (GO) - Biological Process for TRIM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 8188213
GO:0098609 cell-cell adhesion IEA --
GO:1900181 negative regulation of protein localization to nucleus IEA --
genes like me logo Genes that share ontologies with TRIM29: view

No data available for SIGNOR curated interactions for TRIM29 Gene

Transcripts for TRIM29 Gene

Unigene Clusters for TRIM29 Gene

Tripartite motif containing 29:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM29 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: -
SP9: - - -
SP10: - -
SP11: - - -
SP12: - -
SP13: - -
SP14:
SP15: -

ExUns: 18c · 18d · 18e · 18f · 18g ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - - -
SP14:
SP15:

Relevant External Links for TRIM29 Gene

GeneLoc Exon Structure for
TRIM29
ECgene alternative splicing isoforms for
TRIM29

Expression for TRIM29 Gene

mRNA expression in normal human tissues for TRIM29 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM29 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x13.2), Esophagus - Mucosa (x12.8), Skin - Not Sun Exposed (Suprapubic) (x11.4), and Vagina (x5.5).

Protein differential expression in normal tissues from HIPED for TRIM29 Gene

This gene is overexpressed in Cervix (30.0), Hair follicle (21.7), and Nasal epithelium (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM29 Gene



NURSA nuclear receptor signaling pathways regulating expression of TRIM29 Gene:

TRIM29

SOURCE GeneReport for Unigene cluster for TRIM29 Gene:

Hs.504115

mRNA Expression by UniProt/SwissProt for TRIM29 Gene:

Q14134-TRI29_HUMAN
Tissue specificity: Expressed in placenta, prostate and thymus.
genes like me logo Genes that share expression patterns with TRIM29: view

Primer Products

No data available for Protein tissue co-expression partners for TRIM29 Gene

Orthologs for TRIM29 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM29 34 35
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia TRIM29 34 35
  • 89.61 (n)
cow
(Bos Taurus)
Mammalia TRIM29 34 35
  • 88.93 (n)
mouse
(Mus musculus)
Mammalia Trim29 34 16 35
  • 86.71 (n)
rat
(Rattus norvegicus)
Mammalia Trim29 34
  • 86.43 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIM29 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM29 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM29 34 35
  • 67.73 (n)
lizard
(Anolis carolinensis)
Reptilia TRIM29 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim29 34
  • 59.13 (n)
Str.3257 34
African clawed frog
(Xenopus laevis)
Amphibia MGC53484 34
zebrafish
(Danio rerio)
Actinopterygii TRIM29 (38 of 87) 35
  • 30 (a)
OneToMany
CABZ01034858.1 35
  • 29 (a)
OneToMany
ftr19 35 35
  • 29 (a)
OneToMany
TRIM29 (55 of 87) 35
  • 29 (a)
OneToMany
CABZ01034857.1 35
  • 28 (a)
OneToMany
ftr10 35
  • 28 (a)
OneToMany
ftr05 35
  • 27 (a)
OneToMany
ftr27 35
  • 27 (a)
OneToMany
TRIM29 (71 of 87) 35
  • 27 (a)
OneToMany
ftr03 35
  • 26 (a)
OneToMany
ftr08 35
  • 26 (a)
OneToMany
ftr09 35
  • 26 (a)
OneToMany
ftr26 35 35
  • 26 (a)
OneToMany
ftr04 35
  • 25 (a)
OneToMany
ftr28l 35
  • 25 (a)
OneToMany
ftr46 35
  • 25 (a)
OneToMany
ftr69 35
  • 25 (a)
OneToMany
ftr06 35
  • 24 (a)
OneToMany
ftr15 35
  • 24 (a)
OneToMany
ftr67 35
  • 24 (a)
OneToMany
TRIM29 (36 of 87) 35
  • 24 (a)
OneToMany
TRIM29 (50 of 87) 35
  • 24 (a)
OneToMany
TRIM29 (61 of 87) 35
  • 24 (a)
OneToMany
TRIM29 (86 of 87) 35
  • 24 (a)
OneToMany
ftr13 35
  • 23 (a)
OneToMany
ftr50 35
  • 23 (a)
OneToMany
ftr01 35
  • 22 (a)
OneToMany
ftr14l 35
  • 22 (a)
OneToMany
ftr22 35
  • 22 (a)
OneToMany
ftr35 35
  • 22 (a)
OneToMany
ftr38 35
  • 22 (a)
OneToMany
ftr61 35
  • 22 (a)
OneToMany
ftr64 35
  • 22 (a)
OneToMany
TRIM29 (20 of 87) 35
  • 22 (a)
OneToMany
TRIM29 (84 of 87) 35
  • 22 (a)
OneToMany
CR352329.1 35
  • 21 (a)
OneToMany
ftr02 35
  • 21 (a)
OneToMany
ftr07 35
  • 21 (a)
OneToMany
ftr12 35
  • 21 (a)
OneToMany
ftr14 35
  • 21 (a)
OneToMany
ftr23 35
  • 21 (a)
OneToMany
ftr24 35
  • 21 (a)
OneToMany
ftr29 35
  • 21 (a)
OneToMany
ftr30 35
  • 21 (a)
OneToMany
ftr33 35
  • 21 (a)
OneToMany
ftr34 35
  • 21 (a)
OneToMany
ftr36 35
  • 21 (a)
OneToMany
ftr51 35
  • 21 (a)
OneToMany
ftr65 35
  • 21 (a)
OneToMany
ftr72 35
  • 21 (a)
OneToMany
ftr82 35
  • 21 (a)
OneToMany
TRIM29 (44 of 87) 35
  • 21 (a)
OneToMany
TRIM29 (87 of 87) 35
  • 21 (a)
OneToMany
ftr11 35
  • 20 (a)
OneToMany
ftr16 35
  • 20 (a)
OneToMany
ftr37 35
  • 20 (a)
OneToMany
ftr41 35
  • 20 (a)
OneToMany
ftr42 35
  • 20 (a)
OneToMany
ftr43 35
  • 20 (a)
OneToMany
ftr53 35
  • 20 (a)
OneToMany
ftr56 35
  • 20 (a)
OneToMany
ftr58 35
  • 20 (a)
OneToMany
ftr66 35
  • 20 (a)
OneToMany
ftr73 35
  • 20 (a)
OneToMany
ftr83 35
  • 20 (a)
OneToMany
TRIM29 (16 of 87) 35
  • 20 (a)
OneToMany
TRIM29 (42 of 87) 35
  • 20 (a)
OneToMany
TRIM29 (85 of 87) 35
  • 20 (a)
OneToMany
ftr57 35
  • 19 (a)
OneToMany
ftr59 35
  • 19 (a)
OneToMany
ftr76 35
  • 19 (a)
OneToMany
TRIM29 (18 of 87) 35
  • 19 (a)
OneToMany
TRIM29 (19 of 87) 35
  • 19 (a)
OneToMany
ftr55 35
  • 18 (a)
OneToMany
TRIM29 (15 of 87) 35
  • 18 (a)
OneToMany
TRIM29 (41 of 87) 35
  • 18 (a)
OneToMany
TRIM29 (63 of 87) 35
  • 18 (a)
OneToMany
ftr54 35
  • 17 (a)
OneToMany
ftr79 35
  • 17 (a)
OneToMany
TRIM29 (35 of 87) 35
  • 17 (a)
OneToMany
TRIM29 (5 of 87) 35
  • 17 (a)
OneToMany
ftr32 35
  • 16 (a)
OneToMany
TRIM29 (14 of 87) 35
  • 14 (a)
OneToMany
TRIM29 (31 of 87) 35
  • 14 (a)
OneToMany
TRIM29 (82 of 87) 35
  • 13 (a)
OneToMany
Species where no ortholog for TRIM29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM29 Gene

ENSEMBL:
Gene Tree for TRIM29 (if available)
TreeFam:
Gene Tree for TRIM29 (if available)

Paralogs for TRIM29 Gene

Paralogs for TRIM29 Gene

genes like me logo Genes that share paralogs with TRIM29: view

Variants for TRIM29 Gene

Sequence variations from dbSNP and Humsavar for TRIM29 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs112973609 A breast cancer sample 120,118,309(+) CCCGG(A/G)AGGTG reference, missense
rs10466595 -- 120,118,399(+) CAGGT(C/G)TATGA intron-variant
rs10466596 -- 120,118,415(+) TAGCC(G/T)CTGGC intron-variant
rs10736502 -- 120,111,077(+) AAGGC(C/G)TGCCT downstream-variant-500B
rs1075790 -- 120,113,211(+) TCTTC(A/C)CCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM29 Gene

Variant ID Type Subtype PubMed ID
esv2673699 CNV deletion 23128226
esv2745143 CNV deletion 23290073
esv3548424 CNV deletion 23714750
esv3627899 CNV loss 21293372
nsv1050132 CNV gain 25217958
nsv472657 CNV novel sequence insertion 20440878

Variation tolerance for TRIM29 Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM29 Gene

Disorders for TRIM29 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM29 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ataxia-telangiectasia
  • ataxia telangiectasia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIM29

Genetic Association Database (GAD)
TRIM29
Human Genome Epidemiology (HuGE) Navigator
TRIM29
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM29
genes like me logo Genes that share disorders with TRIM29: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM29 Gene

Publications for TRIM29 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3 4 64
  2. Expression of the ATDC (ataxia telangiectasia group D-complementing) gene in A431 human squamous carcinoma cells. (PMID: 8647648) Laderoute K.R. … Kapp L.N. (Int. J. Cancer 1996) 3 4 22 64
  3. The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions. (PMID: 20368352) Yuan Z. … Seto E. (Mol. Cell. Biol. 2010) 3 22 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization. (PMID: 19249679) Wang L. … Simeone D.M. (Cancer Cell 2009) 3 22 64

Products for TRIM29 Gene

Sources for TRIM29 Gene

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