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Aliases for TRIM28 Gene

Aliases for TRIM28 Gene

  • Tripartite Motif Containing 28 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 157 2 3
  • E3 SUMO-Protein Ligase TRIM28 3 4
  • KRAB-Interacting Protein 1 3 4
  • Nuclear Corepressor KAP-1 3 4
  • RING Finger Protein 96 3 4
  • TIF1-Beta 3 4
  • KRIP-1 3 4
  • KAP-1 3 4
  • RNF96 3 4
  • TIF1B 3 4
  • KAP1 3 4
  • KRAB [Kruppel-Associated Box Domain]-Associated Protein 1 3
  • Transcriptional Intermediary Factor 1-Beta 3
  • Transcription Intermediary Factor 1-Beta 3
  • Tripartite Motif-Containing Protein 28 4
  • Tripartite Motif-Containing 28 2
  • KRAB-Associated Protein 1 4
  • EC 6.3.2.- 4
  • PPP1R157 3
  • TF1B 3

External Ids for TRIM28 Gene

Previous GeneCards Identifiers for TRIM28 Gene

  • GC19P059954
  • GC19P059509
  • GC19P063731
  • GC19P063747
  • GC19P063553
  • GC19P059055
  • GC19P055366

Summaries for TRIM28 Gene

Entrez Gene Summary for TRIM28 Gene

  • The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM28 Gene

TRIM28 (Tripartite Motif Containing 28) is a Protein Coding gene. Among its related pathways are Gene Expression and E2F transcription factor network. GO annotations related to this gene include poly(A) RNA binding and sequence-specific DNA binding. An important paralog of this gene is TRIM33.

UniProtKB/Swiss-Prot for TRIM28 Gene

  • Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at Lys-9 (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 Lys-9 and Lys-14 acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). Acts as a corepressor for ZFP568 (By similarity).

Gene Wiki entry for TRIM28 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM28 Gene

Genomics for TRIM28 Gene

Regulatory Elements for TRIM28 Gene

Enhancers for TRIM28 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F057809 1.2 FANTOM5 ENCODE 52.8 -730.9 -730874 7.2 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF134 ZNF805 ZNF264 TRIM28 ZNF256 ZNF543 ZNF417 ZNF773 ZNF17 ENSG00000269867
GH19F058379 0.2 ENCODE 33.7 -163.0 -163006 2.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 RPS5 TRIM28 ZNF584 ZNF548 ZNF134 ZNF324B ZNF132 ZNF587B ZNF837 ZNF417
GH19F058580 1.2 Ensembl ENCODE 30 +37.2 37174 1.5 ATF1 GTF3C2 ZNF143 REST MEF2D MAFF SMARCA4 PBX2 MYNN NBN TRIM28 ZNF587B ZNF324B ZNF134 ZNF587 CENPBD1P1 ZBTB45 UBE2M CHMP2A ZNF417
GH19F058517 0.9 FANTOM5 ENCODE 26.8 -24.4 -24383 4.9 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 ZNF324B CENPBD1P1 ZNF134 LOC105372483 TRIM28 ZNF549 MZF1 ZNF324 ZBTB45 ZNF584
GH19F058571 0.2 ENCODE 26.8 +30.0 30022 4.5 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 TRIM28 CENPBD1P1 ZNF584 ENSG00000268392 ZBTB45 RNU6-1337P ZNF446 RPS5 LOC100506634 MZF1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TRIM28 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001420271 410 3000 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 KLF13 ZNF263

Genomic Location for TRIM28 Gene

Chromosome:
19
Start:
58,544,091 bp from pter
End:
58,550,722 bp from pter
Size:
6,632 bases
Orientation:
Plus strand

Genomic View for TRIM28 Gene

Genes around TRIM28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM28 Gene

Proteins for TRIM28 Gene

  • Protein details for TRIM28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13263-TIF1B_HUMAN
    Recommended name:
    Transcription intermediary factor 1-beta
    Protein Accession:
    Q13263
    Secondary Accessions:
    • O00677
    • Q7Z632
    • Q93040
    • Q96IM1

    Protein attributes for TRIM28 Gene

    Size:
    835 amino acids
    Molecular mass:
    88550 Da
    Quaternary structure:
    • Interacts with SETX (PubMed:23149945). Oligomer; the RBCC domain homotrimerizes and interacts with one molecule of KRAB to form the KRAB-KAP1 corepressor complex. Binding to a KRAB domain is an absolute requirement for silencing gene expression. Interacts with CEBPB and NR3C1. Interacts with a number of KRAB-ZFP proteins including ZNF10, ZFP53, ZFP68, ZNF382 and ZNF256. Interacts with NCOR1, NR3C1 and CHD3. Interacts with CEBPB (via the RING-type and PHD-type zinc fingers). Component of a ternary complex that includes TRIM28, a HP1 protein (CBX1, CBX3 OR CBX5), a KRAB domain-containing protein, and DNA. Interacts with CBX5 (via the PxVxL motif); the interaction occurs in interphase nuclei and competes for binding POGZ. Interacts with POGZ; the interaction competes for interaction with CBX5. Interacts with SETDB1; the interaction is enhanced by KAP1 sumoylation, stimulates SETB1 histone methyltransferase activity and gene silencing. Interacts (via the PHD-type zinc finger) with UBE2I; the interaction is required for sumoylation and repressor activity. Component of the TRIM28/KAP1-ERBB4-MDM2 complex involved in connecting growth factor and DNA damage responses. Interacts directly with ERBB4; the interaction represses ERBB4-mediated transcription activity. Interacts with MDM2; the interaction contributes to p53/TP53 inactivation. Component of the TRIM28/KAP1-MDM2-p53/TP53; involved in regulating p53/TP53 stabilization and activity. Interacts (via the leucine zipper alpha helical coiled-coil) with E2F1 (central region); the interaction inhibits E2F1 acetylation and transcriptional activity. Interacts with PPP1CA; the interaction dephosphorylates TRIM28 at Ser-824 and forms a complex at the p21 promoter site. Interacts with PPP1CB; the interaction is weak but is increased on dephosphorylation at Ser-824. Interacts with FES/FPS. Interacts with SMARCAD1. Interacts with, and sumoylates IRF7. Interacts with MAGEC2. Part of a complex composed of TRIM28, HDAC1, HDAC2 and EHMT2. Interacts with AICDA (By similarity). Interacts (via the RBCC domain) with KOX1 (via the KRAB domain), ZNF268 (via the KRAB domain) and ZNF300 (via the KRAB domain); the interactions increase KOX1, ZNF268 and ZNF300 nuclear localization activities. The large PER complex involved in the histone methylation is composed of at least PER2, CBX3, TRIM28, SUV39H1 and/or SUV39H2; CBX3 mediates the formation of the complex. Interacts with isoform 2 of ZFP90. Forms a complex with FOXP3 in the presence of isoform 2 of ZFP90. Interacts with NR4A3; the interactions potentiates NR4A3 activity on NurRE promoter (By similarity). Interacts (unphosphorylated or phosphorylated form) with ZBTB1 (via BTB domain) (PubMed:24657165). Probably part of a corepressor complex containing ZNF304, TRIM28, SETDB1 and DNMT1 (PubMed:24623306). Interacts with ATRX. Forms a complex with ATRX, SETDB1 and ZNF274 (PubMed:27029610). Interacts with ZFP568; the interaction mediates ZFP568 transcriptional repression activity (By similarity).

    Three dimensional structures from OCA and Proteopedia for TRIM28 Gene

    Alternative splice isoforms for TRIM28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM28 Gene

Post-translational modifications for TRIM28 Gene

  • ATM-induced phosphorylation on Ser-824 represses sumoylation leading to the de-repression of expression of a subset of genes involved in cell cycle control and apoptosis in response to genotoxic stress. Dephosphorylation by the phosphatases, PPP1CA and PP1CB forms, allows sumoylation and expression of TRIM28 target genes.
  • Auto-ubiquitinated; enhanced by MAGEA2 and MAGEC2.
  • Citrullinated by PADI4.
  • Sumoylation/desumoylation events regulate TRIM28-mediated transcriptional repression. Sumoylation is required for interaction with CHD3 and SETDB1 and the corepressor activity. Represses and is repressed by Ser-824 phosphorylation. Enhances the TRIM28 corepressor activity, inhibiting transcriptional activity of a number of genes including GADD45A and CDKN1A/p21. Lys-554, Lys-779 and Lys-804 are the major sites of sumoylation. In response to Dox-induced DNA damage, enhanced phosphorylation on Ser-824 prevents sumoylation and allows de-repression of CDKN1A/p21.
  • Ubiquitination at Lys 31, Lys 127, Lys 213, Lys 238, Lys 254, Lys 261, Lys 272, Lys 304, Lys 319, Lys 337, Lys 340, Lys 366, Lys 377, Lys 400, Lys 407, Lys 434, Lys 469, Lys 750, Lys 770, and Lys 774
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM28 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TRIM28 (TIF1B)

No data available for DME Specific Peptides for TRIM28 Gene

Domains & Families for TRIM28 Gene

Suggested Antigen Peptide Sequences for TRIM28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13263

UniProtKB/Swiss-Prot:

TIF1B_HUMAN :
  • The HP1 box is both necessary and sufficient for HP1 binding.
  • Belongs to the TRIM/RBCC family.
  • Contains 2 B box-type zinc fingers.
Domain:
  • The HP1 box is both necessary and sufficient for HP1 binding.
  • The PHD-type zinc finger enhances CEBPB transcriptional activity. The PHD-type zinc finger, the HP1 box and the bromo domain, function together to assemble the machinery required for repression of KRAB domain-containing proteins. Acts as an intramolecular SUMO E3 ligase for autosumoylation of bromodomain.
  • The RING-finger-B Box-coiled-coil/tripartite motif (RBCC/TRIM motif) is required for interaction with the KRAB domain of KRAB-zinc finger proteins. Binds four zinc ions per molecule. The RING finger and the N-terminal of the leucine zipper alpha helical coiled-coil region of RBCC are required for oligomerization.
  • Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
  • Contains 1 bromo domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 2 B box-type zinc fingers.
  • Contains 1 PHD-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM28: view

Function for TRIM28 Gene

Molecular function for TRIM28 Gene

UniProtKB/Swiss-Prot Function:
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at Lys-9 (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 Lys-9 and Lys-14 acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). Acts as a corepressor for ZFP568 (By similarity).

Enzyme Numbers (IUBMB) for TRIM28 Gene

Gene Ontology (GO) - Molecular Function for TRIM28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001105 RNA polymerase II transcription coactivator activity ISS --
GO:0003677 DNA binding IDA 9016654
GO:0003682 chromatin binding IDA 27029610
GO:0003700 contributes_to transcription factor activity, sequence-specific DNA binding ISS --
GO:0003713 transcription coactivator activity IEA --
genes like me logo Genes that share ontologies with TRIM28: view
genes like me logo Genes that share phenotypes with TRIM28: view

Animal Models for TRIM28 Gene

MGI Knock Outs for TRIM28:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM28 Gene

Localization for TRIM28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM28 Gene

Nucleus. Note=Associated with centromeric heterochromatin during cell differentiation through CBX1. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM28 Gene COMPARTMENTS Subcellular localization image for TRIM28 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TRIM28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,ISS --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005719 nuclear euchromatin IEA --
genes like me logo Genes that share ontologies with TRIM28: view

Pathways & Interactions for TRIM28 Gene

genes like me logo Genes that share pathways with TRIM28: view

Pathways by source for TRIM28 Gene

2 Reactome pathways for TRIM28 Gene

UniProtKB/Swiss-Prot Q13263-TIF1B_HUMAN

  • Pathway: Protein modification; protein sumoylation.

SIGNOR curated interactions for TRIM28 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for TRIM28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001837 epithelial to mesenchymal transition ISS --
GO:0006281 DNA repair IDA 17178852
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TRIM28: view

Drugs & Compounds for TRIM28 Gene

(1) Drugs for TRIM28 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TRIM28 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRIM28: view

Transcripts for TRIM28 Gene

Unigene Clusters for TRIM28 Gene

Tripartite motif containing 28:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM28 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^
SP1: - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - - - -
SP5:
SP6: - - - - - - -
SP7: - - - -
SP8: -
SP9:
SP10: - - - - - - - - - - - - - - - -
SP11: - - -
SP12: - -
SP13:
SP14:
SP15:

ExUns: 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - - - - - - -
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for TRIM28 Gene

GeneLoc Exon Structure for
TRIM28
ECgene alternative splicing isoforms for
TRIM28

Expression for TRIM28 Gene

mRNA expression in normal human tissues for TRIM28 Gene

Protein differential expression in normal tissues from HIPED for TRIM28 Gene

This gene is overexpressed in Lymph node (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM28 Gene



Protein tissue co-expression partners for TRIM28 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM28 Gene:

TRIM28

SOURCE GeneReport for Unigene cluster for TRIM28 Gene:

Hs.467408

mRNA Expression by UniProt/SwissProt for TRIM28 Gene:

Q13263-TIF1B_HUMAN
Tissue specificity: Expressed in all tissues tested including spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with TRIM28: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRIM28 Gene

Orthologs for TRIM28 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM28 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM28 34 35
  • 89.08 (n)
cow
(Bos Taurus)
Mammalia TRIM28 34 35
  • 88.3 (n)
rat
(Rattus norvegicus)
Mammalia Trim28 34
  • 85.98 (n)
mouse
(Mus musculus)
Mammalia Trim28 34 16 35
  • 85.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM28 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 58 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia TRIM28 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489687 34
  • 59.94 (n)
Str.3172 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.18843 34
zebrafish
(Danio rerio)
Actinopterygii trim33l 35
  • 13 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bon 36
  • 28 (a)
mei-P26 35
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nhl-2 35
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9380 35
  • 25 (a)
OneToMany
Species where no ortholog for TRIM28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM28 Gene

ENSEMBL:
Gene Tree for TRIM28 (if available)
TreeFam:
Gene Tree for TRIM28 (if available)

Paralogs for TRIM28 Gene

Paralogs for TRIM28 Gene

Pseudogenes.org Pseudogenes for TRIM28 Gene

genes like me logo Genes that share paralogs with TRIM28: view

Variants for TRIM28 Gene

Sequence variations from dbSNP and Humsavar for TRIM28 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs193921106 Uncertain significance 58,550,038(+) CTGGT(G/T)AGTCC intron-variant, upstream-variant-2KB
rs398122526 untested 58,548,431(+) CCTCA(C/G/T)TCTGT intron-variant, upstream-variant-2KB
rs1049540 -- 58,550,592(+) CTGTT(C/T)TCTGT downstream-variant-500B, utr-variant-3-prime
rs10534787 -- 58,543,075(+) ATGTG(-/TA)TATAT upstream-variant-2KB
rs1065354 -- 58,550,418(+) CGCTT(C/T)TTCGA downstream-variant-500B, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TRIM28 Gene

Variant ID Type Subtype PubMed ID
dgv3687n100 CNV gain 25217958
dgv3688n100 CNV gain 25217958
nsv1057077 CNV gain 25217958
nsv1057206 CNV gain 25217958
nsv1144885 CNV deletion 24896259
nsv1160670 CNV deletion 26073780
nsv515731 CNV gain+loss 19592680
nsv828657 CNV gain 20364138
nsv952156 CNV deletion 24416366

Variation tolerance for TRIM28 Gene

Residual Variation Intolerance Score: 4.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM28 Gene

Disorders for TRIM28 Gene

Relevant External Links for TRIM28

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM28

No disorders were found for TRIM28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM28 Gene

Publications for TRIM28 Gene

  1. Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains. (PMID: 11226167) Capili A.D. … Borden K.L. (EMBO J. 2001) 2 3 4 22 64
  2. SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1. (PMID: 20424263) Li X. … Ann D.K. (Sci. Signal. 2010) 3 4 22 64
  3. A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1. (PMID: 18060868) Suzuki C. … Takahashi M. (Biochem. Biophys. Res. Commun. 2008) 3 4 22 64
  4. Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing. (PMID: 18488044) Zeng L. … Zhou M.M. (Nat. Struct. Mol. Biol. 2008) 3 4 22 64
  5. Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells. (PMID: 17079232) Lee Y.K. … Ann D.K. (J. Biol. Chem. 2007) 3 4 22 64

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