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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM27 Gene

protein-coding   GIFtS: 53
GCID: GC06M028870

Tripartite Motif Containing 27

(Previous names: ret finger protein, tripartite motif-containing 27)
(Previous symbol: RFP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tripartite Motif Containing 271 2     RING Finger Protein 762 3
RFP1 2 3 5     RFP Transforming Protein2
Ret Finger Protein1 2 3     Tripartite Motif Protein TRIM272
Tripartite Motif-Containing 271 2     Zinc Finger Protein RFP2
Tripartite Motif-Containing Protein 272 3     EC 6.3.2.-3
RNF762 3     

External Ids:    HGNC: 99751   Entrez Gene: 59872   Ensembl: ENSG000002047137   OMIM: 6021655   UniProtKB: P143733   

Export aliases for TRIM27 gene to outside databases

Previous GC identifers: GC06M028979 GC06M028678


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRIM27 Gene:
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding
domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the
nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also
thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with
the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming
protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRIM27 Gene: 
TRIM27 (tripartite motif containing 27) is a protein-coding gene. Diseases associated with TRIM27 include shigellosis, and familial mediterranean fever. GO annotations related to this gene include transmembrane receptor protein tyrosine kinase activity and nucleic acid binding. An important paralog of this gene is TRIM7.

UniProtKB/Swiss-Prot: TRI27_HUMAN, P14373
Function: Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun
N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial
events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to
double-stranded DNA (By similarity). E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and
inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4
T-cell activation

Gene Wiki entry for TRIM27 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NT_113891.2  NT_167244.1  NT_167248.1  NT_167249.1  NC_018917.2  NT_167246.1  
NT_167247.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM27 gene promoter:
         SRY   AP-1   MyoD   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM27 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22

TRIM27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM27 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M028870:  view genomic region     (about GC identifiers)

Start:
28,870,779 bp from pter      End:
28,891,768 bp from pter
Size:
20,990 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_113891.2 393,803-414,796      Chr6-,NT_167248 174,180-195,169      Chr6-,NT_167247 174,342-195,331     
Chr6-,NT_167244 174,180-195,170      Chr6-,NT_167249 211,702-232,682      Chr6-,NT_167246 191,190-195,170     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRI27_HUMAN, P14373 (See protein sequence)
Recommended Name: Zinc finger protein RFP  
Size: 513 amino acids; 58490 Da
Subunit: Homomultimerizes. Interacts with PML, EIF3S6, EPC1, CHD4 and EID1. Interacts with MAGED4, MAGEF1 and
MAGEL2
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Nucleus, PML body (By similarity).
Note=Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in
nuclear bodies
Secondary accessions: A2BE15 Q5RJA8 Q5ST26 Q6LA73 Q6NXR9 Q9BZY6 Q9UJL3
Alternative splicing: 2 isoforms:  P14373-1   P14373-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIM27: NX_P14373

Explore proteomics data for TRIM27 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P14373

  • TRIM27 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRIM27 Protein Expression
    REFSEQ proteins: NP_006501.1  
    ENSEMBL proteins: 
     ENSP00000400058   ENSP00000366399   ENSP00000366404  

    Human Recombinant Protein Products for TRIM27: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIM27 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA17156811
    GO:0005654nucleoplasm IDA10976108
    GO:0005737cytoplasm IDA17156811
    GO:0005887integral to plasma membrane TAS3078962

    TRIM27 for ontologies           About GeneDecksing



    TRIM27 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    5/12 InterPro protein domains (see all 12):
     IPR006574 PRY
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR020457 Znf_B-box_chordata

    Graphical View of Domain Structure for InterPro Entry P14373

    ProtoNet protein and cluster: P14373

    4 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: TRI27_HUMAN, P14373
    Domain: The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate
    interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain
    mediates interaction with EIF3S6
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    TRIM27 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI27_HUMAN, P14373
    Function: Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun
    N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial
    events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to
    double-stranded DNA (By similarity). E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and
    inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4
    T-cell activation

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding TAS3380101
    GO:0003677DNA binding IEA--
    GO:0004714transmembrane receptor protein tyrosine kinase activity TAS3078962
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding IPI10504338
         
    TRIM27 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Trim27):
     cellular  homeostasis/metabolism  immune system  no phenotypic analysis  tumorigenesis 

    TRIM27 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Trim27tm1Sis for TRIM27

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRIM27 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRIM27

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM27 
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    SwitchGear 3'UTR luciferase reporter plasmidTRIM27 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRIM27 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein Stability
    Protein Stability

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for TRIM27
        Protein Stability



    TRIM27 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRIM27

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/85 Interacting proteins for TRIM27 (P143731, 2, 3 ENSP000003664044) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2862673 I2D: score=3 STRING: ENSP00000344782
    FBF1Q8TES72, 3, ENSP000003242924MINT-66471 I2D: score=1 STRING: ENSP00000324292
    DNMT1P263582, 3MINT-63610 I2D: score=5 
    MCOLN1Q9GZU12, 3MINT-65431 I2D: score=5 
    KCTD15Q96SI12, 3MINT-65370 I2D: score=4 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA10976108
    GO:0002820negative regulation of adaptive immune response IMP--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006469negative regulation of protein kinase activity IDA--
    GO:0007283spermatogenesis TAS3380101

    TRIM27 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRIM27 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM27 (TRI27)

    2 Novoseek inferred chemical compound relationships for TRIM27 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 30 5 10571821 (1), 10976108 (1), 12807881 (1), 12787916 (1)
    zinc 29.7 5 10571821 (1), 2112113 (1), 9247190 (1), 9023983 (1)

    Search CenterWatch for drugs/clinical trials and news about TRIM27 / TRI27

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRIM27 gene (2 alternative transcripts): 
    NM_006510.4  NM_030950.2  

    Unigene Cluster for TRIM27:

    Tripartite motif containing 27
    Hs.440382  [show with all ESTs]
    Unigene Representative Sequence: NM_006510
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000414543 ENST00000481474(uc003nlt.1) ENST00000377194 ENST00000377199(uc003nlr.3 uc003nls.3)
    ENST00000467742 ENST00000498117 ENST00000496091
    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM27:
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    SwitchGear 3'UTR luciferase reporter plasmidTRIM27 3' UTR sequence
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    Additional mRNA sequence: 

    AF230393.1 AF230394.1 AJ420519.1 BC013580.1 BC066924.1 J03407.1 

    11 DOTS entries:

    DT.65286447  DT.40123394  DT.97855071  DT.97855070  DT.100807109  DT.206399  DT.95280354  DT.100807098 
    DT.121317327  DT.40267798  DT.91975851 

    24/426 AceView cDNA sequences (see all 426):

    J03407 BQ056876 CB305776 AW613163 BU162559 CB267869 BQ054222 BQ186498 
    H79770 AA451843 CB143629 BM726999 AA157370 CA307523 BU621833 AA737429 
    AV707738 BU628408 T73286 AF230393 CA425394 BQ062362 BM465143 BE867506 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGTTCTCA
    TRIM27 Expression
    About this image


    See TRIM27 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM27

    SOURCE GeneReport for Unigene cluster: Hs.440382

    UniProtKB/Swiss-Prot: TRI27_HUMAN, P14373
    Tissue specificity: Expressed in testis namely within the seminiferous tubules

        SABiosciences Expression via Pathway-Focused PCR Arrays including TRIM27: 
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              Epigenetic Chromatin Remodeling Factors in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM27 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim271 , 5 tripartite motif-containing 271, 5 91.29(n)1
    98.83(a)1
      13 (7.67 cM)5
    197201  NM_009054.31  NP_033080.21 
     211794455 
    chicken
    (Gallus gallus)
    Aves TRIM271 tripartite motif containing 27 56.91(n)
    43.01(a)
      425772  NM_001099354.1  NP_001092824.1 


    ENSEMBL Gene Tree for TRIM27 (if available)
    TreeFam Gene Tree for TRIM27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM27 gene
    TRIM72  TRIM42  TRIM262  TRIM392  TRIM342  TRIM582  TRIM682  TRIM102  
    TRIM152  TRIM602  TRIM222  TRIM172  TRIM52  TRIM62  TRIM6-TRIM342  TRIM212  
    TRIM382  TRIM112  TRIM39-RPP212  
    18/53 SIMAP similar genes for TRIM27 using alignment to 4 protein entries:     TRI27_HUMAN (see all proteins) (see all similar genes):
    ERMAP    BTN1A1    BTN2A2    FLJ00123    BTNL3    TRIM39
    BTNL8    TRIM11    DKFZp666N1710    TRIM69    TRIM21    MEFV
    TRIM31    TRIM5    TRIM68    RFPL2    RFPL3    BT3.3

    TRIM27 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/539 SNPs in TRIM27 are shown (see all 539)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1131744791,2
    C--28870340(+) GTCAGG/AAGTTC 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs2091271,2
    C,F--28870391(-) TTTTTG/ATTTTT 1 -- ds50014Minor allele frequency- A:0.25WA NA 8
    rs1414367641,2
    --28870496(+) GAGCCA/GAGATC 1 -- ds50010--------
    rs1917074241,2
    --28870519(+) TCTAGA/GCTGGG 1 -- ds50010--------
    rs1835382461,2
    --28870566(+) TGTAGC/GCTATG 1 -- ds50010--------
    rs1451848091,2
    --28870656(+) AGTAAA/GCTATT 1 -- ds50010--------
    rs1378804021,2
    --28870802(+) TTATTA/TTTAAA 1 -- ut310--------
    rs10560651,2
    C--28870843(-) TGGTTC/TTCAGT 1 -- ut31 ese31Minor allele frequency- T:0.00NA 2
    rs412706041,2
    C--28870847(+) AGAACC/TATCAT 1 -- ut312Minor allele frequency- T:0.07NA WA 120
    rs10560321,2
    C,F,A,H--28870975(-) TTGGGG/AGAAGG 1 -- ut31 trp317Minor allele frequency- A:0.11MN NS EA CSA WA NA 2521

    HapMap Linkage Disequilibrium report for TRIM27 (28870779 - 28891768 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TRIM27:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv5238CNV Insertion18451855
    nsv883518CNV Loss21882294
    nsv883519CNV Gain21882294
    nsv830622CNV Gain17160897
    nsv462667CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602165    OMIM disorders: --

    UniProtKB/Swiss-Prot: TRI27_HUMAN, P14373
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an
    irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm
    characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered
    with a surface layer of neoplastic epithelial cells. Note=The disease is caused by mutations affecting the gene
    represented in this entry. A chromosomal aberration involving TRIM27/RFP is found in thyroid papillary
    carcinomas. Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates TRIM27/RET and delta
    TRIM27/RET oncogenes

  • 16 diseases for TRIM27:    About MalaCards
    shigellosis    familial mediterranean fever    hemochromatosis    papillary thyroid carcinoma
    germ cell tumors    b-cell chronic lymphocytic leukemia    papillary carcinoma    macular degeneration
    retinoblastoma    chronic lymphocytic leukemia    thyroiditis    ataxia
    systemic lupus erythematosus    lupus erythematosus    leukemia    squamous cell carcinoma


    TRIM27 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TRIM27 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    promyelocytic leukemia 50 1 9023983 (1)
    leukemia 2.7 2 2112113 (1)

    Genetic Association Database (GAD): TRIM27
    Human Genome Epidemiology (HuGE) Navigator: TRIM27 (2 documents)

    Export disorders for TRIM27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM27 gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with TRIM27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Ret finger protein induces apoptosis via its RING finger-B box- coiled-coil motif. (PubMed id 12807881)1, 2, 9 Dho S.H. and Kwon K.S. (2003)
    2. RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions. (PubMed id 10976108)1, 2, 9 Shimono Y.... Takahashi M. (2000)
    3. Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML. (PubMed id 9570750)1, 2, 9 Cao T.... Etkin L.D. (1998)
    4. Involvement of the rfp tripartite motif in protein-protein interactions and subcellular distribution. (PubMed id 9247190)1, 2, 9 Cao T.... Etkin L.D. (1997)
    5. Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities. (PubMed id 14530259)1, 2, 9 Shimono Y....Takahashi M. (2003)
    6. Selective ablation of retinoblastoma protein function by the RET finger protein. (PubMed id 15837424)1, 2, 9 Krutzfeldt M.... Mittnacht S. (2005)
    7. Novel tumorigenic rearrangement, Delta rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient. (PubMed id 12787916)1, 2, 9 Saenko V.... Yamashita S. (2003)
    8. Differential expression of RET finger protein in testicular germ cell tumors. (PubMed id 12445133)1, 2, 9 Tezel G.... Takahashi M. (2002)
    9. Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies. (PubMed id 10504338)1, 2, 9 Morris-Desbois C.... Jalinot P. (1999)
    10. Tripartite motif containing protein 27 negatively reg ulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2I^. (PubMed id 22128329)1, 2 Cai X....Skolnik E.Y. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5987 HGNC: 9975 AceView: RFP Ensembl:ENSG00000204713 euGenes: HUgn5987
    ECgene: TRIM27 H-InvDB: TRIM27

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM27 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRIM27 gene:
    Search GeneIP for patents involving TRIM27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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