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Aliases for TRIM27 Gene

Aliases for TRIM27 Gene

  • Tripartite Motif Containing 27 2 3 5
  • Ret Finger Protein 2 3 4
  • RING-Type E3 Ubiquitin Transferase TRIM27 3 4
  • Tripartite Motif-Containing Protein 27 3 4
  • RING Finger Protein 76 3 4
  • RNF76 3 4
  • RFP 3 4
  • Tripartite Motif Protein TRIM27 3
  • Tripartite Motif-Containing 27 2
  • RFP Transforming Protein 3
  • Zinc Finger Protein RFP 3
  • EC 2.3.2.27 4

External Ids for TRIM27 Gene

Previous HGNC Symbols for TRIM27 Gene

  • RFP

Previous GeneCards Identifiers for TRIM27 Gene

  • GC06M028979
  • GC06M028870
  • GC06M028678

Summaries for TRIM27 Gene

Entrez Gene Summary for TRIM27 Gene

  • This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM27 Gene

TRIM27 (Tripartite Motif Containing 27) is a Protein Coding gene. Diseases associated with TRIM27 include Differentiated Thyroid Carcinoma. GO annotations related to this gene include nucleic acid binding and ubiquitin-protein transferase activity. An important paralog of this gene is TRIM7.

UniProtKB/Swiss-Prot for TRIM27 Gene

  • E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of Lys-48-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of Lys-63-linked polyubiquitin chains at Lys-220 of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.

Gene Wiki entry for TRIM27 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM27 Gene

Genomics for TRIM27 Gene

Regulatory Elements for TRIM27 Gene

Enhancers for TRIM27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G028865 1.9 FANTOM5 Ensembl ENCODE dbSUPER 39.4 +57.4 57419 2.1 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF766 TRIM27 ZKSCAN4 ZKSCAN3 ZFP57 ZKSCAN8 ZSCAN9 ZNF603P ZNF602P LINC01556 ZSCAN31
GH06G028977 1.7 Ensembl ENCODE dbSUPER 36.5 -56.4 -56384 6.5 CREB3L1 MLX DMAP1 FEZF1 YBX1 YY1 ZNF143 SP3 NFYC MEF2D ZKSCAN3 TRIM27 ZKSCAN4 ZKSCAN8 ZNF311 HLA-K ZFP57 HCG4B ZNF602P ZNF603P
GH06G028838 1.2 ENCODE 50.8 +85.5 85512 2.2 CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC GLIS1 RCOR2 NBN TRIM27 ZKSCAN3 ZKSCAN4 LINC01556 RPL23AP1 IFITM4P ZFP57 HCG14 ZKSCAN8 HLA-F-AS1
GH06G028947 1.2 ENCODE dbSUPER 48.4 -24.4 -24371 1.7 FOXA2 ARID4B ZNF48 YY1 FOS GTF2B PPARG KAT8 SREBF1 MIER3 TRIM27 ZFP57 HCG15 ENSG00000244349 ZKSCAN3 ZKSCAN4 HCG14 HLA-K HLA-A ZNF602P
GH06G028894 1.5 ENCODE dbSUPER 37.5 +27.1 27102 3.9 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF416 ZKSCAN3 TRIM27 ZKSCAN4 ZKSCAN8 ZSCAN9 SUMO2P1 ZSCAN26 ZNF603P ZFP57 ENSG00000244349
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM27 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195288 391 2401 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D SSRP1

Transcription factor binding sites by QIAGEN in the TRIM27 gene promoter:

Genomic Location for TRIM27 Gene

Chromosome:
6
Start:
28,903,002 bp from pter
End:
28,923,991 bp from pter
Size:
20,990 bases
Orientation:
Minus strand

Genomic View for TRIM27 Gene

Genes around TRIM27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TRIM27 Gene

  • Protein details for TRIM27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14373-TRI27_HUMAN
    Recommended name:
    Zinc finger protein RFP
    Protein Accession:
    P14373
    Secondary Accessions:
    • A2BE15
    • Q5RJA8
    • Q5ST26
    • Q6LA73
    • Q6NXR9
    • Q9BZY6
    • Q9UJL3

    Protein attributes for TRIM27 Gene

    Size:
    513 amino acids
    Molecular mass:
    58490 Da
    Quaternary structure:
    • Homomultimerizes. Interacts with PML, EIF3S6, EPC1, CHD4 and EID1. Interacts with MAGED4, MAGEF1 and MAGEL2. Interacts with herpes simplex virus protein ICP0.

    Alternative splice isoforms for TRIM27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM27 Gene

Post-translational modifications for TRIM27 Gene

  • Ubiquitination at Lys79, isoforms=2151, posLast=283283, posLast=292292, isoforms=2304, Lys380, and Lys382
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM27 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM27 Gene

Domains & Families for TRIM27 Gene

Gene Families for TRIM27 Gene

Graphical View of Domain Structure for InterPro Entry

P14373

UniProtKB/Swiss-Prot:

TRI27_HUMAN :
  • The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain mediates interaction with EIF3S6.
  • Belongs to the TRIM/RBCC family.
Domain:
  • The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain mediates interaction with EIF3S6.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM27: view

Function for TRIM27 Gene

Molecular function for TRIM27 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of Lys-48-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of Lys-63-linked polyubiquitin chains at Lys-220 of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.

Enzyme Numbers (IUBMB) for TRIM27 Gene

Gene Ontology (GO) - Molecular Function for TRIM27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding TAS 3380101
GO:0003677 DNA binding IEA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity TAS 3078962
GO:0004842 ubiquitin-protein transferase activity IMP 23452853
GO:0005515 protein binding IPI 9570750
genes like me logo Genes that share ontologies with TRIM27: view
genes like me logo Genes that share phenotypes with TRIM27: view

Animal Models for TRIM27 Gene

MGI Knock Outs for TRIM27:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRIM27

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM27 Gene

Localization for TRIM27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM27 Gene

Nucleus. Cytoplasm. Nucleus, PML body. Early endosome. Note=Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies. Recruited to retromer-containing endosomes via interaction with MAGEL2 (PubMed:23452853). {ECO:0000250, ECO:0000269 PubMed:23452853}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM27 gene
Compartment Confidence
nucleus 5
endosome 5
plasma membrane 4
cytosol 3

Gene Ontology (GO) - Cellular Components for TRIM27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 17156811
GO:0005654 nucleoplasm IDA 10976108
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with TRIM27: view

Pathways & Interactions for TRIM27 Gene

SuperPathways for TRIM27 Gene

No Data Available

SIGNOR curated interactions for TRIM27 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for TRIM27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 10976108
GO:0002820 negative regulation of adaptive immune response IMP 22128329
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006469 negative regulation of protein kinase activity IDA 22128329
genes like me logo Genes that share ontologies with TRIM27: view

No data available for Pathways by source for TRIM27 Gene

Drugs & Compounds for TRIM27 Gene

(2) Drugs for TRIM27 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TRIM27: view

Transcripts for TRIM27 Gene

Unigene Clusters for TRIM27 Gene

Tripartite motif containing 27:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM27 Gene

No ASD Table

Relevant External Links for TRIM27 Gene

GeneLoc Exon Structure for
TRIM27
ECgene alternative splicing isoforms for
TRIM27

Expression for TRIM27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM27 Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for TRIM27 Gene

This gene is overexpressed in Testis (16.2), Fetal ovary (14.2), Placenta (11.4), and Pancreas (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM27 Gene



Protein tissue co-expression partners for TRIM27 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM27 Gene:

TRIM27

SOURCE GeneReport for Unigene cluster for TRIM27 Gene:

Hs.440382

mRNA Expression by UniProt/SwissProt for TRIM27 Gene:

P14373-TRI27_HUMAN
Tissue specificity: Expressed in testis namely within the seminiferous tubules.

Evidence on tissue expression from TISSUES for TRIM27 Gene

  • Nervous system(3.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM27 Gene

Germ Layers:
  • endoderm
Systems:
  • endocrine
Organs:
Head and neck:
  • neck
  • thyroid
genes like me logo Genes that share expression patterns with TRIM27: view

Primer Products

Orthologs for TRIM27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM27 34 35
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia TRIM27 34 35
  • 94.41 (n)
dog
(Canis familiaris)
Mammalia TRIM27 34 35
  • 93.36 (n)
rat
(Rattus norvegicus)
Mammalia Trim27 34
  • 91.68 (n)
mouse
(Mus musculus)
Mammalia Trim27 34 16 35
  • 91.29 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TRIM27 34
  • 57.05 (n)
Species where no ortholog for TRIM27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM27 Gene

ENSEMBL:
Gene Tree for TRIM27 (if available)
TreeFam:
Gene Tree for TRIM27 (if available)

Paralogs for TRIM27 Gene

Variants for TRIM27 Gene

Sequence variations from dbSNP and Humsavar for TRIM27 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000001217 -- 28,906,740(+) GTTAA(A/T)TTTAC intron-variant
rs1000093868 -- 28,922,861(+) TGTCT(G/T)AGAGC intron-variant
rs1000185611 -- 28,912,830(+) TTTGG(C/G)GGTGC intron-variant
rs1000392625 -- 28,924,119(+) TCCGC(C/T)ACTCT upstream-variant-2KB
rs1000945893 -- 28,919,865(+) TTCCT(C/T)CCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM27 Gene

Variant ID Type Subtype PubMed ID
esv3608464 CNV gain 21293372
nsv1074388 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259
nsv462667 CNV gain 19166990
nsv5238 CNV insertion 18451855
nsv601212 CNV gain 21841781
nsv830622 CNV gain 17160897

Variation tolerance for TRIM27 Gene

Residual Variation Intolerance Score: 22.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM27 Gene

Disorders for TRIM27 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM27 Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TRI27_HUMAN
  • Note=A chromosomal aberration involving TRIM27/RFP is found in papillary thyroid carcinomas (PTCs). Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates TRIM27/RET and delta TRIM27/RET oncogenes. {ECO:0000269 PubMed:12787916, ECO:0000269 PubMed:3037315}.

Relevant External Links for TRIM27

Genetic Association Database (GAD)
TRIM27
Human Genome Epidemiology (HuGE) Navigator
TRIM27
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM27
genes like me logo Genes that share disorders with TRIM27: view

No data available for Genatlas for TRIM27 Gene

Publications for TRIM27 Gene

  1. Selective ablation of retinoblastoma protein function by the RET finger protein. (PMID: 15837424) Krutzfeldt M. … Mittnacht S. (Mol. Cell 2005) 3 4 22 64
  2. Novel tumorigenic rearrangement, Delta rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient. (PMID: 12787916) Saenko V. … Yamashita S. (Mutat. Res. 2003) 3 4 22 64
  3. The Ret finger protein induces apoptosis via its RING finger-B box- coiled-coil motif. (PMID: 12807881) Dho S.H. … Kwon K.S. (J. Biol. Chem. 2003) 3 4 22 64
  4. Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities. (PMID: 14530259) Shimono Y. … Takahashi M. (J. Biol. Chem. 2003) 3 4 22 64
  5. Differential expression of RET finger protein in testicular germ cell tumors. (PMID: 12445133) Tezel G. … Takahashi M. (Pathol. Int. 2002) 3 4 22 64

Products for TRIM27 Gene

Sources for TRIM27 Gene

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