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Aliases for TRIM27 Gene

Aliases for TRIM27 Gene

  • Tripartite Motif Containing 27 2 3
  • Ret Finger Protein 2 3 4
  • Tripartite Motif-Containing Protein 27 3 4
  • Tripartite Motif-Containing 27 2 3
  • RING Finger Protein 76 3 4
  • RNF76 3 4
  • RFP 3 4
  • Tripartite Motif Protein TRIM27 3
  • RFP Transforming Protein 3
  • EC 6.3.2.- 4

External Ids for TRIM27 Gene

Previous HGNC Symbols for TRIM27 Gene

  • RFP

Previous GeneCards Identifiers for TRIM27 Gene

  • GC06M028979
  • GC06M028870
  • GC06M028678

Summaries for TRIM27 Gene

Entrez Gene Summary for TRIM27 Gene

  • This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM27 Gene

TRIM27 (Tripartite Motif Containing 27) is a Protein Coding gene. Diseases associated with TRIM27 include differentiated thyroid carcinoma. GO annotations related to this gene include nucleic acid binding and ubiquitin-protein transferase activity. An important paralog of this gene is TRIM58.

UniProtKB/Swiss-Prot for TRIM27 Gene

  • E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of Lys-48-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of Lys-63-linked polyubiquitin chains at Lys-220 of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.

Gene Wiki entry for TRIM27 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM27 Gene

Genomics for TRIM27 Gene

Regulatory Elements for TRIM27 Gene

Transcription factor binding sites by QIAGEN in the TRIM27 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIM27 Gene

Chromosome:
6
Start:
28,903,002 bp from pter
End:
28,923,991 bp from pter
Size:
20,990 bases
Orientation:
Minus strand

Genomic View for TRIM27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TRIM27 Gene

  • Protein details for TRIM27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14373-TRI27_HUMAN
    Recommended name:
    Zinc finger protein RFP
    Protein Accession:
    P14373
    Secondary Accessions:
    • A2BE15
    • Q5RJA8
    • Q5ST26
    • Q6LA73
    • Q6NXR9
    • Q9BZY6
    • Q9UJL3

    Protein attributes for TRIM27 Gene

    Size:
    513 amino acids
    Molecular mass:
    58490 Da
    Quaternary structure:
    • Homomultimerizes. Interacts with PML, EIF3S6, EPC1, CHD4 and EID1. Interacts with MAGED4, MAGEF1 and MAGEL2. Interacts with herpes simplex virus protein ICP0.

    Alternative splice isoforms for TRIM27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM27 Gene

Proteomics data for TRIM27 Gene at MOPED

Post-translational modifications for TRIM27 Gene

  • Ubiquitination at Lys 79, Lys 151, Lys 283, Lys 292, Lys 304, Lys 380, and Lys 382
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM27 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TRIM27 (TRIM27)
  • Santa Cruz Biotechnology (SCBT) Antibodies for TRIM27

No data available for DME Specific Peptides for TRIM27 Gene

Domains & Families for TRIM27 Gene

Graphical View of Domain Structure for InterPro Entry

P14373

UniProtKB/Swiss-Prot:

TRI27_HUMAN :
  • The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain mediates interaction with EIF3S6
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Domain:
  • The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain mediates interaction with EIF3S6
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM27: view

Function for TRIM27 Gene

Molecular function for TRIM27 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of Lys-48-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of Lys-63-linked polyubiquitin chains at Lys-220 of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.

Enzyme Numbers (IUBMB) for TRIM27 Gene

Gene Ontology (GO) - Molecular Function for TRIM27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding TAS 3380101
GO:0003677 DNA binding IEA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity TAS 3078962
GO:0004842 ubiquitin-protein transferase activity IMP 23452853
GO:0005515 protein binding IPI 9570750
genes like me logo Genes that share ontologies with TRIM27: view
genes like me logo Genes that share phenotypes with TRIM27: view

Animal Models for TRIM27 Gene

MGI Knock Outs for TRIM27:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM27

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for TRIM27 Gene

Localization for TRIM27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM27 Gene

Nucleus. Cytoplasm. Nucleus, PML body. Early endosome. Note=Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies. Recruited to retromer-containing endosomes via interaction with MAGEL2 (PubMed:23452853). {ECO:0000250, ECO:0000269 PubMed:23452853}.

Gene Ontology (GO) - Cellular Components for TRIM27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 17156811
GO:0005654 nucleoplasm IDA 10976108
GO:0005737 cytoplasm IDA 17156811
GO:0005768 endosome IDA 23452853
genes like me logo Genes that share ontologies with TRIM27: view

No data available for Subcellular locations from COMPARTMENTS for TRIM27 Gene

Pathways & Interactions for TRIM27 Gene

SuperPathways for TRIM27 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for TRIM27 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for TRIM27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 10976108
GO:0002820 negative regulation of adaptive immune response IMP 22128329
GO:0006351 transcription, DNA-templated IEA --
GO:0006469 negative regulation of protein kinase activity IDA 22128329
GO:0007283 spermatogenesis TAS 3380101
genes like me logo Genes that share ontologies with TRIM27: view

No data available for Pathways by source for TRIM27 Gene

Drugs & Compounds for TRIM27 Gene

(2) Drugs for TRIM27 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
tyrosine Nutra 547
genes like me logo Genes that share compounds with TRIM27: view

Transcripts for TRIM27 Gene

Unigene Clusters for TRIM27 Gene

Tripartite motif containing 27:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM27

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM27 Gene

No ASD Table

Relevant External Links for TRIM27 Gene

GeneLoc Exon Structure for
TRIM27
ECgene alternative splicing isoforms for
TRIM27

Expression for TRIM27 Gene

mRNA expression in normal human tissues for TRIM27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM27 Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for TRIM27 Gene

This gene is overexpressed in Testis (16.2), Fetal ovary (14.2), Placenta (11.4), and Pancreas (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM27 Gene



SOURCE GeneReport for Unigene cluster for TRIM27 Gene Hs.440382

mRNA Expression by UniProt/SwissProt for TRIM27 Gene

P14373-TRI27_HUMAN
Tissue specificity: Expressed in testis namely within the seminiferous tubules.
genes like me logo Genes that share expression patterns with TRIM27: view

Protein tissue co-expression partners for TRIM27 Gene

Primer Products

In Situ Assay Products

Orthologs for TRIM27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM27 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIM27 35
  • 94.41 (n)
  • 99.42 (a)
TRIM27 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM27 35
  • 93.36 (n)
  • 99.18 (a)
TRIM27 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim27 35
  • 91.29 (n)
  • 98.83 (a)
Trim27 16
Trim27 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIM27 35
  • 99.55 (n)
  • 100 (a)
TRIM27 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim27 35
  • 91.68 (n)
  • 98.44 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 30 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TRIM27 35
  • 57.05 (n)
  • 42.95 (a)
Species with no ortholog for TRIM27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM27 Gene

ENSEMBL:
Gene Tree for TRIM27 (if available)
TreeFam:
Gene Tree for TRIM27 (if available)

Paralogs for TRIM27 Gene

genes like me logo Genes that share paralogs with TRIM27: view

Variants for TRIM27 Gene

Sequence variations from dbSNP and Humsavar for TRIM27 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs4361641 -- 28,904,728(+) CCCAG(A/C/T)GCCTT intron-variant
rs28381620 -- 28,929,791(+) CGATT(-/A/AA)AAAAA upstream-variant-2KB
rs80176860 -- 28,921,394(+) AAAAA(-/A/AAA)TTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM27 Gene

Variant ID Type Subtype PubMed ID
nsv883518 CNV Loss 21882294
nsv883519 CNV Gain 21882294
nsv462667 CNV Gain 19166990
nsv830622 CNV Gain 17160897
nsv5238 CNV Insertion 18451855

Variation tolerance for TRIM27 Gene

Residual Variation Intolerance Score: 22.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM27 Gene

HapMap Linkage Disequilibrium report
TRIM27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM27 Gene

Disorders for TRIM27 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM27 Gene - From: Orphanet

Disorder Aliases PubMed IDs
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
- elite association

UniProtKB/Swiss-Prot

TRI27_HUMAN
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving TRIM27/RFP is found in thyroid papillary carcinomas. Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates TRIM27/RET and delta TRIM27/RET oncogenes.

Relevant External Links for TRIM27

Genetic Association Database (GAD)
TRIM27
Human Genome Epidemiology (HuGE) Navigator
TRIM27
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM27
genes like me logo Genes that share disorders with TRIM27: view

No data available for Genatlas for TRIM27 Gene

Publications for TRIM27 Gene

  1. Expression of Ret finger protein correlates with outcomes in endometrial cancer. (PMID: 19650860) Tsukamoto H. … Takahashi M. (Cancer Sci. 2009) 23 67
  2. Ret Finger Protein: An E3 Ubiquitin Ligase Juxtaposed to the XY Body in Meiosis. (PMID: 20145714) Gillot I. … Lopez P. (Int J Cell Biol 2009) 23 67
  3. RET finger protein expression in invasive breast carcinoma: relationship between RFP and ErbB2 expression. (PMID: 19232840) Tezel G.G. … Takahashi M. (Pathol. Res. Pract. 2009) 23 67
  4. Characterization of the HDAC1 complex that regulates the sensitivity of cancer cells to oxidative stress. (PMID: 19351825) Kato T. … Takahashi M. (Cancer Res. 2009) 23 67
  5. The RET finger protein interacts with the hinge region of SMC3. (PMID: 15781269) Patel C.A. … Ghiselli G. (Biochem. Biophys. Res. Commun. 2005) 23 67

Products for TRIM27 Gene

Sources for TRIM27 Gene

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