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Aliases for TRIM27 Gene

Aliases for TRIM27 Gene

  • Tripartite Motif Containing 27 2 3
  • Ret Finger Protein 2 3 4
  • RFP 3 4 6
  • Tripartite Motif-Containing Protein 27 3 4
  • Tripartite Motif-Containing 27 2 3
  • RING Finger Protein 76 3 4
  • RNF76 3 4
  • Tripartite Motif Protein TRIM27 3
  • RFP Transforming Protein 3
  • Zinc Finger Protein RFP 3
  • EC 6.3.2.- 4

External Ids for TRIM27 Gene

Previous Symbols for TRIM27 Gene

  • RFP

Summaries for TRIM27 Gene

Entrez Gene Summary for TRIM27 Gene

  • This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM27 Gene

TRIM27 (Tripartite Motif Containing 27) is a Protein Coding gene. Diseases associated with TRIM27 include thyroid carcinoma, papillary. Among its related pathways are Protein Stability. GO annotations related to this gene include ubiquitin-protein transferase activity and transmembrane receptor protein tyrosine kinase activity. An important paralog of this gene is TRIM58.

UniProtKB/Swiss-Prot for TRIM27 Gene

  • E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of Lys-48-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of Lys-63-linked polyubiquitin chains at Lys-220 of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.

Gene Wiki entry for TRIM27 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM27 Gene

Genomics for TRIM27 Gene

Genomic Location for TRIM27 Gene

Start:
28,903,002 bp from pter
End:
28,923,991 bp from pter
Size:
20,990 bases
Orientation:
Minus strand

Genomic View for TRIM27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for TRIM27 Gene

Transcription factor binding sites by QIAGEN in the TRIM27 gene promoter:

Proteins for TRIM27 Gene

  • Protein details for TRIM27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14373-TRI27_HUMAN
    Recommended name:
    Zinc finger protein RFP
    Protein Accession:
    P14373
    Secondary Accessions:
    • A2BE15
    • Q5RJA8
    • Q5ST26
    • Q6LA73
    • Q6NXR9
    • Q9BZY6
    • Q9UJL3

    Protein attributes for TRIM27 Gene

    Size:
    513 amino acids
    Molecular mass:
    58490 Da
    Quaternary structure:
    • Homomultimerizes. Interacts with PML, EIF3S6, EPC1, CHD4 and EID1. Interacts with MAGED4, MAGEF1 and MAGEL2. Interacts with herpes simplex virus protein ICP0.

    Alternative splice isoforms for TRIM27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM27 Gene

Proteomics data for TRIM27 Gene at MOPED

Post-translational modifications for TRIM27 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys79, Lys151, Lys283, Lys292, Lys304, Lys380, and Lys382

Other Protein References for TRIM27 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM27 Gene

Domains for TRIM27 Gene

Gene Families for TRIM27 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

UniProtKB/Swiss-Prot:

TRI27_HUMAN
Domain:
  • The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain mediates interaction with EIF3S6:
    • P14373
  • Contains 1 B30.2/SPRY domain.:
    • P14373
Family:
  • Belongs to the TRIM/RBCC family.:
    • P14373
Similarity:
  • Contains 1 B box-type zinc finger.:
    • P14373
  • Contains 1 RING-type zinc finger.:
    • P14373
genes like me logo Genes that share domains with TRIM27: view

Function for TRIM27 Gene

Molecular function for TRIM27 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of Lys-48-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of Lys-63-linked polyubiquitin chains at Lys-220 of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.

Enzyme Numbers (IUBMB) for TRIM27 Gene

Gene Ontology (GO) - Molecular Function for TRIM27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding TAS 3380101
GO:0003677 DNA binding IEA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity TAS 3078962
GO:0004842 ubiquitin-protein transferase activity IMP 23452853
GO:0005515 protein binding IPI 10504338
genes like me logo Genes that share ontologies with TRIM27: view
genes like me logo Genes that share phenotypes with TRIM27: view

Animal Models for TRIM27 Gene

MGI Knock Outs for TRIM27:

miRNA for TRIM27 Gene

miRTarBase miRNAs that target TRIM27

No data available for Transcription Factor Targeting and HOMER Transcription for TRIM27 Gene

Localization for TRIM27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM27 Gene

Nucleus. Cytoplasm. Nucleus, PML body. Early endosome. Note=Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies. Recruited to retromer-containing endosomes via interaction with MAGEL2 (PubMed:23452853). {ECO:0000250, ECO:0000269 PubMed:23452853}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM27 Gene COMPARTMENTS Subcellular localization image for TRIM27 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TRIM27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 17156811
GO:0005654 nucleoplasm IDA 10976108
GO:0005737 cytoplasm IDA 17156811
GO:0005768 endosome IDA 23452853
genes like me logo Genes that share ontologies with TRIM27: view

Pathways for TRIM27 Gene

SuperPathways for TRIM27 Gene

Superpath Contained pathways
1 Protein Stability
genes like me logo Genes that share pathways with TRIM27: view

Pathways by source for TRIM27 Gene

1 Cell Signaling Technology pathway for TRIM27 Gene

Gene Ontology (GO) - Biological Process for TRIM27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 10976108
GO:0002820 negative regulation of adaptive immune response IMP 22128329
GO:0006351 transcription, DNA-templated IEA --
GO:0006469 negative regulation of protein kinase activity IDA 22128329
GO:0007283 spermatogenesis TAS 3380101
genes like me logo Genes that share ontologies with TRIM27: view

Compounds for TRIM27 Gene

(2) Novoseek inferred chemical compound relationships for TRIM27 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 30 4
zinc 29.7 4
genes like me logo Genes that share compounds with TRIM27: view

Transcripts for TRIM27 Gene

Unigene Clusters for TRIM27 Gene

Tripartite motif containing 27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM27 Gene

No ASD Table

Relevant External Links for TRIM27 Gene

GeneLoc Exon Structure for
TRIM27
ECgene alternative splicing isoforms for
TRIM27

Expression for TRIM27 Gene

mRNA expression in normal human tissues for TRIM27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM27 Gene

This gene is overexpressed in Whole Blood (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM27 Gene

SOURCE GeneReport for Unigene cluster for TRIM27 Gene Hs.440382

mRNA Expression by UniProt/SwissProt for TRIM27 Gene

P14373-TRI27_HUMAN
Tissue specificity: Expressed in testis namely within the seminiferous tubules.
genes like me logo Genes that share expressions with TRIM27: view

Orthologs for TRIM27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM27 36
  • 99.55 (n)
  • 100 (a)
TRIM27 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM27 36
  • 94.41 (n)
  • 99.42 (a)
TRIM27 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM27 36
  • 93.36 (n)
  • 99.18 (a)
TRIM27 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim27 36
  • 91.29 (n)
  • 98.83 (a)
Trim27 16
Trim27 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 30 (a)
ManyToMany
-- 37
  • 38 (a)
ManyToMany
-- 37
  • 42 (a)
ManyToMany
-- 37
  • 35 (a)
ManyToMany
-- 37
  • 31 (a)
ManyToMany
-- 37
  • 36 (a)
ManyToMany
-- 37
  • 35 (a)
ManyToMany
-- 37
  • 36 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Trim27 36
  • 91.68 (n)
  • 98.44 (a)
chicken
(Gallus gallus)
Aves TRIM27 36
  • 57.05 (n)
  • 42.95 (a)
Species with no ortholog for TRIM27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM27 Gene

ENSEMBL:
Gene Tree for TRIM27 (if available)
TreeFam:
Gene Tree for TRIM27 (if available)

Paralogs for TRIM27 Gene

genes like me logo Genes that share paralogs with TRIM27: view

Variants for TRIM27 Gene

Sequence variations from dbSNP and Humsavar for TRIM27 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs172325 -- 28,913,216(-) gtaca(A/G)tggca intron-variant
rs209121 -- 28,913,883(-) AGTCA(A/G)AAGAT intron-variant
rs209122 -- 28,907,725(-) TGTGA(A/G)AAATT intron-variant
rs209123 -- 28,905,283(-) attct(A/G)tgaaa intron-variant
rs209124 -- 28,904,965(-) actgc(A/G)ctcca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM27 Gene

Variant ID Type Subtype PubMed ID
nsv883518 CNV Loss 21882294
nsv883519 CNV Gain 21882294
nsv462667 CNV Gain 19166990
nsv830622 CNV Gain 17160897
nsv5238 CNV Insertion 18451855

Relevant External Links for TRIM27 Gene

HapMap Linkage Disequilibrium report
TRIM27

Disorders for TRIM27 Gene

UniProtKB/Swiss-Prot

TRI27_HUMAN
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving TRIM27/RFP is found in thyroid papillary carcinomas. Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates TRIM27/RET and delta TRIM27/RET oncogenes.

(2) Novoseek inferred disease relationships for TRIM27 Gene

Disease -log(P) Hits PubMed IDs
promyelocytic leukemia 50 1
leukemia 2.7 1

Relevant External Links for TRIM27

Genetic Association Database (GAD)
TRIM27
Human Genome Epidemiology (HuGE) Navigator
TRIM27
genes like me logo Genes that share disorders with TRIM27: view

Publications for TRIM27 Gene

  1. Involvement of the rfp tripartite motif in protein-protein interactions and subcellular distribution. (PMID: 9247190) Cao T. … Etkin L.D. (J. Cell Sci. 1997) 3 4 23
  2. Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML. (PMID: 9570750) Cao T. … Etkin L.D. (J. Cell Sci. 1998) 3 4 23
  3. Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies. (PMID: 10504338) Morris-Desbois C. … Jalinot P. (J. Cell Sci. 1999) 3 4 23
  4. Differential expression of RET finger protein in testicular germ cell tumors. (PMID: 12445133) Tezel G. … Takahashi M. (Pathol. Int. 2002) 3 4 23
  5. Novel tumorigenic rearrangement, Delta rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient. (PMID: 12787916) Saenko V. … Yamashita S. (Mutat. Res. 2003) 3 4 23

Products for TRIM27 Gene

Sources for TRIM27 Gene

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