Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TRIM27 Gene

protein-coding   GIFtS: 53
GCID: GC06M028870

Tripartite Motif Containing 27

(Previous names: ret finger protein, tripartite motif-containing 27)
(Previous symbol: RFP)
  See TRIM27-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Tripartite Motif Containing 271 2     RING Finger Protein 762 3
RFP1 2 3 5     RFP Transforming Protein2
Ret Finger Protein1 2 3     Tripartite Motif Protein TRIM272
Tripartite Motif-Containing 271 2     Zinc Finger Protein RFP2
Tripartite Motif-Containing Protein 272 3     EC 6.3.2.-3
RNF762 3     

External Ids:    HGNC: 99751   Entrez Gene: 59872   Ensembl: ENSG000002047137   OMIM: 6021655   UniProtKB: P143733   

Export aliases for TRIM27 gene to outside databases

Previous GC identifers: GC06M028979 GC06M028678


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TRIM27 Gene:
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding
domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the
nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also
thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with
the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming
protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRIM27 Gene:
TRIM27 (tripartite motif containing 27) is a protein-coding gene. Diseases associated with TRIM27 include follicular thyroid carcinoma. GO annotations related to this gene include ubiquitin-protein ligase activity and transmembrane receptor protein tyrosine kinase activity. An important paralog of this gene is TRIM7.

UniProtKB/Swiss-Prot: TRI27_HUMAN, P14373
Function: Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun
N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial
events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to
double-stranded DNA (By similarity). E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and
inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4
T-cell activation

Gene Wiki entry for TRIM27 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167244.2  NT_167246.2  NT_167247.2  NT_167248.2  
NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM27 gene promoter:
         SRY   AP-1   MyoD   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM27 promoter sequence
   Search Chromatin IP Primers for TRIM27

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22

TRIM27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM27 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M028870:  view genomic region     (about GC identifiers)

Start:
28,870,779 bp from pter      End:
28,891,768 bp from pter
Size:
20,990 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_167244 174,180-195,170      Chr6-,NT_167247 174,342-195,331      Chr6-,NT_167246 191,190-195,170     
Chr6-,NT_167249 211,702-232,682      Chr6-,NT_113891.2 393,803-414,796      Chr6-,NT_167248 174,180-195,169     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TRI27_HUMAN, P14373 (See protein sequence)
Recommended Name: Zinc finger protein RFP  
Size: 513 amino acids; 58490 Da
Subunit: Homomultimerizes. Interacts with PML, EIF3S6, EPC1, CHD4 and EID1. Interacts with MAGED4, MAGEF1 and
MAGEL2
Secondary accessions: A2BE15 Q5RJA8 Q5ST26 Q6LA73 Q6NXR9 Q9BZY6 Q9UJL3
Alternative splicing: 2 isoforms:  P14373-1   P14373-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIM27: NX_P14373

Explore proteomics data for TRIM27 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys79, Lys151, Lys283, Lys292, Lys304, Lys380, Lys382
  • Modification sites at PhosphoSitePlus

  • See TRIM27 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006501.1  
    ENSEMBL proteins: 
     ENSP00000400058   ENSP00000366399   ENSP00000366404  

    TRIM27 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TRIM27
    OriGene Protein Over-expression Lysate for TRIM27
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TRIM27
    GenScript Custom Purified and Recombinant Proteins Services for TRIM27
    Novus Biologicals TRIM27 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIM27

     
    Search eBioscience for Proteins for TRIM27 

    TRIM27 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for TRIM27 
    OriGene Antibodies for TRIM27
    OriGene Custom Antibody Services for TRIM27
    Novus Biologicals TRIM27 Antibodies
    Abcam antibodies for TRIM27
    Cloud-Clone Corp. Antibodies for TRIM27
    ThermoFisher Antibody for TRIM27
    LSBio Antibodies in human, mouse, rat for TRIM27

    TRIM27 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRIM27
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRIM27
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRIM27
    Cloud-Clone Corp. CLIAs for TRIM27
    Search eBioscience for ELISAs for TRIM27 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 12):
     IPR006574 PRY
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR020457 Znf_B-box_chordata

    Graphical View of Domain Structure for InterPro Entry P14373

    ProtoNet protein and cluster: P14373

    4 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: TRI27_HUMAN, P14373
    Domain: The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate
    interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain
    mediates interaction with EIF3S6
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with TRIM27           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI27_HUMAN, P14373
    Function: Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun
    N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial
    events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to
    double-stranded DNA (By similarity). E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and
    inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4
    T-cell activation

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding TAS3380101
    GO:0003677DNA binding IEA--
    GO:0004714transmembrane receptor protein tyrosine kinase activity TAS3078962
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding IPI10504338
         
    Find genes that share ontologies with TRIM27           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Trim27):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  no phenotypic analysis 
     tumorigenesis 

    Find genes that share phenotypes with TRIM27           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Trim27tm1Sis for TRIM27

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM27
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRIM27

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM27
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM27

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRIM27:
    hsa-mir-1260b (MIRT052686), hsa-mir-421 (MIRT039436)

    Block miRNA regulation of human, mouse, rat TRIM27 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate TRIM27:
    hsa-miR-550a hsa-miR-1245 hsa-miR-29b-1* hsa-miR-455-3p hsa-miR-4257 hsa-miR-3159
    SwitchGear 3'UTR luciferase reporter plasmidTRIM27 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRIM27
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM27

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRIM27

    Clone
    Products:
         
    OriGene clones in human, mouse for TRIM27 (see all 7)
    OriGene ORF clones in mouse, rat for TRIM27
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIM27 (NM_006510)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM27
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM27
    Addgene plasmids for TRIM27 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRIM27
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRIM27 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM27


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TRI27_HUMAN, P14373: Nucleus (By similarity). Cytoplasm (By similarity). Nucleus, PML body (By similarity).
    Note=Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in
    nuclear bodies
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane4
    cytosol2
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA17156811
    GO:0005654nucleoplasm IDA10976108
    GO:0005737cytoplasm IDA17156811
    GO:0005887integral component of plasma membrane TAS3078962

    Find genes that share ontologies with TRIM27           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TRIM27 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein Stability
    Protein Stability


    Find genes that share SuperPaths with TRIM27           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for TRIM27
        Protein Stability


        Pathway & Disease-focused RT2 Profiler PCR Arrays including TRIM27: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRIM27

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for TRIM27 (P143731, 2, 3 ENSP000003664044) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2862673 I2D: score=3 STRING: ENSP00000344782
    FBF1Q8TES72, 3, ENSP000003242924MINT-66471 I2D: score=1 STRING: ENSP00000324292
    DNMT1P263582, 3MINT-63610 I2D: score=5 
    MCOLN1Q9GZU12, 3MINT-65431 I2D: score=5 
    KCTD15Q96SI12, 3MINT-65370 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA10976108
    GO:0002820negative regulation of adaptive immune response IMP--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006469negative regulation of protein kinase activity IDA--
    GO:0007283spermatogenesis TAS3380101

    Find genes that share ontologies with TRIM27           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM27 (TRI27)

    2 Novoseek inferred chemical compound relationships for TRIM27 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 30 5 10571821 (1), 10976108 (1), 12807881 (1), 12787916 (1)
    zinc 29.7 5 10571821 (1), 2112113 (1), 9247190 (1), 9023983 (1)



    Find genes that share compounds with TRIM27           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TRIM27 gene (2 alternative transcripts): 
    NM_006510.4  NM_030950.2  

    Unigene Cluster for TRIM27:

    Tripartite motif containing 27
    Hs.440382  [show with all ESTs]
    Unigene Representative Sequence: NM_006510
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000414543 ENST00000481474(uc003nlt.1) ENST00000377194 ENST00000377199(uc003nlr.3 uc003nls.3)
    ENST00000467742 ENST00000498117 ENST00000496091
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRIM27 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate TRIM27:
    hsa-miR-550a hsa-miR-1245 hsa-miR-29b-1* hsa-miR-455-3p hsa-miR-4257 hsa-miR-3159
    SwitchGear 3'UTR luciferase reporter plasmidTRIM27 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRIM27
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM27
    Clone
    Products:
         
    OriGene clones in human, mouse for TRIM27 (see all 7)
    OriGene ORF clones in mouse, rat for TRIM27
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIM27 (NM_006510)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM27
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM27
    Addgene plasmids for TRIM27 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRIM27
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM27
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM27
      QuantiTect SYBR Green Assays in human, mouse, rat TRIM27
      QuantiFast Probe-based Assays in human, mouse, rat TRIM27

    Additional mRNA sequence: 

    AF230393.1 AF230394.1 AJ420519.1 BC013580.1 BC066924.1 J03407.1 

    11 DOTS entries:

    DT.65286447  DT.40123394  DT.97855071  DT.97855070  DT.100807109  DT.206399  DT.95280354  DT.100807098 
    DT.121317327  DT.40267798  DT.91975851 

    Selected AceView cDNA sequences (see all 426):

    AI093523 AL523815 BQ054222 AA987771 W94615 BQ898328 BU633079 BM465143 
    CB305776 BX102132 BE327539 BX420634 BE784347 BM994606 BM854440 CA425394 
    BM843074 H79765 AV652958 AW498777 N54660 CB242815 CB267869 BU839646 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TRIM27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGTTCTCA
    TRIM27 Expression
    About this image


    TRIM27 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Long-time differentiated EBs
     
     NULL (Uncategorized)
             Short-term differentiated embryoid bodies
    TRIM27 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM27 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.440382

    UniProtKB/Swiss-Prot: TRI27_HUMAN, P14373
    Tissue specificity: Expressed in testis namely within the seminiferous tubules

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TRIM27: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TRIM27
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM27
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM27
    QuantiTect SYBR Green Assays in human, mouse, rat TRIM27
    QuantiFast Probe-based Assays in human, mouse, rat TRIM27
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM27 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim271 , 5 tripartite motif-containing 271, 5 91.29(n)1
    98.83(a)1
      13 (7.67 cM)5
    197201  NM_009054.31  NP_033080.21 
     211794455 
    chicken
    (Gallus gallus)
    Aves TRIM271 tripartite motif containing 27 57.05(n)
    42.95(a)
      425772  NM_001099354.1  NP_001092824.1 


    ENSEMBL Gene Tree for TRIM27 (if available)
    TreeFam Gene Tree for TRIM27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TRIM27 gene
    TRIM72  TRIM42  TRIM392  TRIM342  TRIML12  TRIM582  TRIM682  TRIM602  
    TRIM222  TRIM172  TRIM52  TRIM62  TRIM6-TRIM342  TRIM212  TRIM382  TRIM112  
    TRIM39-RPP212  
    Selected SIMAP similar genes for TRIM27 using alignment to 2 protein entries:     TRI27_HUMAN (see all proteins) (see all similar genes):
    ERMAP    BTN2A2    MEFV    BTNL8    TRIM11    TRIM39
    TRIM69    RFPL2    RFPL3    BT3.3    RFPL1    RFPL4A
    TRIM39R    TRIM21    RFPL4AL1    TRIM68    TRIM7    BTNL9

    Find genes that share paralogs with TRIM27           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TRIM27 (see all 539)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1131744791,2
    C--28870340(+) GTCAGG/AAGTTC 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs2091271,2
    C,F--28870391(-) TTTTTG/ATTTTT 1 -- ds50014Minor allele frequency- A:0.25WA NA 8
    rs1414367641,2
    --28870496(+) GAGCCA/GAGATC 1 -- ds50010--------
    rs1917074241,2
    --28870519(+) TCTAGA/GCTGGG 1 -- ds50010--------
    rs1835382461,2
    --28870566(+) TGTAGC/GCTATG 1 -- ds50010--------
    rs1451848091,2
    --28870656(+) AGTAAA/GCTATT 1 -- ds50010--------
    rs1378804021,2
    --28870802(+) TTATTA/TTTAAA 1 -- ut310--------
    rs10560651,2
    C--28870843(-) TGGTTC/TTCAGT 1 -- ut31 ese31Minor allele frequency- T:0.00NA 2
    rs412706041,2
    C--28870847(+) AGAACC/TATCAT 1 -- ut312Minor allele frequency- T:0.07NA WA 120
    rs10560321,2
    C,F,A,H--28870975(-) TTGGGG/AGAAGG 1 -- ut31 trp317Minor allele frequency- A:0.11MN NS EA CSA WA NA 2521

    HapMap Linkage Disequilibrium report for TRIM27 (28870779 - 28891768 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TRIM27:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5238CNV Insertion18451855
    nsv883518CNV Loss21882294
    nsv883519CNV Gain21882294
    nsv830622CNV Gain17160897
    nsv462667CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM27
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM27

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602165    OMIM disorders: --

    UniProtKB/Swiss-Prot: TRI27_HUMAN, P14373
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an
    irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm
    characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered
    with a surface layer of neoplastic epithelial cells. Note=The disease is caused by mutations affecting the gene
    represented in this entry. A chromosomal aberration involving TRIM27/RFP is found in thyroid papillary
    carcinomas. Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates TRIM27/RET and delta
    TRIM27/RET oncogenes

  • 1 disease for TRIM27:    
    About MalaCards
    follicular thyroid carcinoma


    Find genes that share disorders with TRIM27           About GenesLikeMe

    2 Novoseek inferred disease relationships for TRIM27 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    promyelocytic leukemia 50 1 9023983 (1)
    leukemia 2.7 2 2112113 (1)

    Genetic Association Database (GAD): TRIM27
    Human Genome Epidemiology (HuGE) Navigator: TRIM27 (2 documents)

    Export disorders for TRIM27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TRIM27 gene, integrated from 10 sources (see all 79):
    (articles sorted by number of sources associating them with TRIM27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Ret finger protein induces apoptosis via its RING finger-B box- coiled-coil motif. (PubMed id 12807881)1, 2, 9 Dho S.H. and Kwon K.S. (J. Biol. Chem. 2003)
    2. RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions. (PubMed id 10976108)1, 2, 9 Shimono Y.... Takahashi M. (J. Biol. Chem. 2000)
    3. Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML. (PubMed id 9570750)1, 2, 9 Cao T.... Etkin L.D. (J. Cell Sci. 1998)
    4. Involvement of the rfp tripartite motif in protein-protein interactions and subcellular distribution. (PubMed id 9247190)1, 2, 9 Cao T.... Etkin L.D. (J. Cell Sci. 1997)
    5. Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities. (PubMed id 14530259)1, 2, 9 Shimono Y....Takahashi M. (J. Biol. Chem. 2003)
    6. Selective ablation of retinoblastoma protein function by the RET finger protein. (PubMed id 15837424)1, 2, 9 Krutzfeldt M.... Mittnacht S. (Mol. Cell 2005)
    7. Novel tumorigenic rearrangement, Delta rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient. (PubMed id 12787916)1, 2, 9 Saenko V.... Yamashita S. (Mutat. Res. 2003)
    8. Differential expression of RET finger protein in testicular germ cell tumors. (PubMed id 12445133)1, 2, 9 Tezel G.... Takahashi M. (Pathol. Int. 2002)
    9. Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies. (PubMed id 10504338)1, 2, 9 Morris-Desbois C.... Jalinot P. (J. Cell Sci. 1999)
    10. Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2beta. (PubMed id 22128329)1, 2 Cai X.... Skolnik E.Y. (Proc. Natl. Acad. Sci. U.S.A. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5987 HGNC: 9975 AceView: RFP Ensembl:ENSG00000204713 euGenes: HUgn5987
    ECgene: TRIM27 H-InvDB: TRIM27

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TRIM27 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TRIM27 gene:
    Search GeneIP for patents involving TRIM27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TRIM27   OriGene RNAi products in human, mouse, rat for TRIM27  
     OriGene qPCR primer pairs and template standards for TRIM27   OriGene Protein Over-expression Lysate for TRIM27  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TRIM27  
     OriGene qSTAR qPCR primer pairs in human, mouse for TRIM27   OriGene Purified Protein for TRIM27  
     OriGene ORF clones in mouse, rat for TRIM27   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRIM27   OriGene Custom Protein Services for TRIM27  

     
     
     Block miRNA regulation of human, mouse, rat TRIM27 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TRIM27
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM27 Predesigned siRNA for gene silencing in human, mouse, rat TRIM27
     QuantiFast Probe-based Assays in human, mouse, rat TRIM27 QuantiTect SYBR Green Assays in human, mouse, rat TRIM27
     PCR Arrays including human, mouse, rat TRIM27 Search Chromatin IP Primers for TRIM27
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM27  GeneGlobe Interaction Network for TRIM27
     Regulatory tfbs in TRIM27 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TRIM27 GenScript cDNA clones with any tag delivered in your preferred vector for TRIM27
     GenScript Custom Assay Services for TRIM27 GenScript Custom overexpressing Cell Line Services for TRIM27
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for TRIM27 

     Search Tocris compounds for TRIM27 (TRI27)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TRIM27 antibodies
     TRIM27 lysates
     Antibodies for TRIM27
     See all of Abcam's Antibodies, Kits and Proteins for TRIM27
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TRIM27
     Antibodies for TRIM27
     ELISAs for TRIM27
     CLIAs for TRIM27



     Browse ESI BIO Cell Lines and PureStem Progenitors for TRIM27
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM27
     SwitchGear 3'UTR luciferase reporter plasmids for TRIM27
     SwitchGear Promoter luciferase reporter plasmids for TRIM27
     ThermoFisher Antibody for TRIM27
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM27
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM27
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRIM27
     LSBio Antibodies in human, mouse, rat for TRIM27
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for TRIM27
      Search eBioscience for proteins for TRIM27
      Search eBioscience for elisas for TRIM27
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TRIM27 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4