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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM27 Gene

protein-coding   GIFtS: 50
GCID: GC06M028870

tripartite motif containing 27

(Previous names: ret finger protein, tripartite motif-containing 27 )
(Previous symbol: RFP)
 Explore 20 diseases affiliated with
TRIM27 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRIM27    

Aliases
for TRIM27 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tripartite Motif Containing 271 2     RING Finger Protein 762 3
RFP1 2 3 5     RFP Transforming Protein2
Ret Finger Protein1 2 3     Tripartite Motif Protein TRIM272
RNF761 2 3     Zinc Finger Protein RFP2
Tripartite Motif-Containing 271 2     EC 6.3.2.-3
Tripartite Motif-Containing Protein 272 3     

External Ids:    HGNC: 99751   Entrez Gene: 59872   Ensembl: ENSG000002047137   OMIM: 6021655   UniProtKB: P143733   

Export aliases for TRIM27 gene to outside databases

Previous GC identifers: GC06M028979 GC06M028678


Summaries
for TRIM27 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TRIM27:
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a
RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It
interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in
the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the
RET gene product has been shown to result in production of the ret transforming protein. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: TRI27_HUMAN, P14373
Function: Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun
N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May
function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA (By
similarity). E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates
the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation

Gene Wiki entry for TRIM27


Genomic Views
for TRIM27 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167244.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM27 gene promoter:
         SRY   AP-1   MyoD   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRIM27 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22

TRIM27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM27 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M028870:  view genomic region     (about GC identifiers)

Start:
 28,870,779 bp from pter      End:
 28,891,768 bp from pter
Size:
 20,990 bases      Orientation:
 minus strand

6 alternative locations:
Chr6-,ALT_REF_LOCI_4 28,810,849-28,814,829      Chr6-,ALT_REF_LOCI_6 28,870,783-28,927,353      Chr6-,ALT_REF_LOCI_2 28,871,599-28,931,780     
Chr6-,ALT_REF_LOCI_5 28,785,765-28,806,754      Chr6-,ALT_REF_LOCI_1 28,870,783-28,900,073      Chr6-,ALT_REF_LOCI_7 28,801,167-28,822,147     

Proteins
for TRIM27 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TRI27_HUMAN, P14373 (See protein sequence)
Recommended Name: Zinc finger protein RFP  
Size: 513 amino acids; 58490 Da
Subunit: Homomultimerizes. Interacts with PML, EIF3S6, EPC1, CHD4 and EID1. Interacts with MAGED4, MAGEF1 and MAGEL2
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Nucleus, PML body (By similarity).
Note=Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear
bodies
Secondary accessions: A2BE15 Q5RJA8 Q5ST26 Q6LA73 Q6NXR9 Q9BZY6 Q9UJL3
Alternative splicing: 2 isoforms:  P14373-1   P14373-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIM27: NX_P14373

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P14373

    • TRIM27 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006501.1  
    ENSEMBL proteins: 
     ENSP00000366404   ENSP00000366399   ENSP00000400058  

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    Uscn Proteins for TRIM27

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005634nucleus IDA17156811
    GO:0005654nucleoplasm IDA10976108
    GO:0005737cytoplasm IDA17156811
    GO:0005887integral to plasma membrane TAS3078962


    TRIM27 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TRIM27

    Protein Domains /
    Families
    for TRIM27 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRIM27 for domains           About GeneDecksing

    5/12 InterPro domains/families (see all 12):
     IPR006574 PRY
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR020457 Znf_B-box_chordata

    Graphical View of Domain Structure for InterPro Entry P14373

    ProtoNet protein and cluster: P14373

    4 Blocks protein families:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: TRI27_HUMAN, P14373
    Domain: The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate
    interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain
    mediates interaction with EIF3S6
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    Function
    for TRIM27 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TRI27_HUMAN, P14373
    Function: Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun
    N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May
    function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA (By
    similarity). E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates
    the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM27:
    hsa-miR-550a hsa-miR-1245 hsa-miR-29b-1* hsa-miR-455-3p hsa-miR-4257 hsa-miR-3159
    SwitchGear 3'UTR luciferase reporter plasmid: TRIM27 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: TRIM27
    OriGene siRNA: TRIM27
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding TAS3380101
    GO:0003677DNA binding IEA--
    GO:0004714transmembrane receptor protein tyrosine kinase activity TAS3078962
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding IPI--


    TRIM27 for ontologies           About GeneDecksing


    Animal Models:
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Trim27):
     cellular  homeostasis/metabolism  immune system  tumorigenesis 

    TRIM27 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TRIM27 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRIM27

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/79 Interacting proteins for TRIM27 (P143731, 2, 3 ENSP000003664044) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2862673 I2D: score=3 STRING: ENSP00000344782
    FBF1Q8TES72, 3, ENSP000003242924MINT-66471 I2D: score=1 STRING: ENSP00000324292
    DNMT1P263582, 3MINT-63610 I2D: score=5 
    MCOLN1Q9GZU12, 3MINT-65431 I2D: score=5 
    KCTD15Q96SI12, 3MINT-65370 I2D: score=4 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA10976108
    GO:0002820negative regulation of adaptive immune response IMP--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006469negative regulation of protein kinase activity IDA--
    GO:0007283spermatogenesis TAS3380101


    TRIM27 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRIM27 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRIM27 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM27
    2 Novoseek chemical compound relationships for TRIM27 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 30 5 10571821 (1), 10976108 (1), 12807881 (1), 12787916 (1)
    zinc 29.7 5 10571821 (1), 2112113 (1), 9247190 (1), 9023983 (1)

    Search CenterWatch for drugs/clinical trials and news about TRIM27 / TRI27 

    Transcripts
    for TRIM27 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRIM27 gene (2 alternative transcripts): 
    NM_006510.4  NM_030950.2  

    Unigene Cluster for TRIM27:

    Tripartite motif containing 27
    Hs.440382  [show with all ESTs]
    Unigene Representative Sequence: NM_006510
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377199(uc003nlr.3 uc003nls.3) ENST00000377194 ENST00000414543
    ENST00000481474(uc003nlt.1) ENST00000467742 ENST00000498117 ENST00000496091


    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM27:
    hsa-miR-550a hsa-miR-1245 hsa-miR-29b-1* hsa-miR-455-3p hsa-miR-4257 hsa-miR-3159
    SwitchGear 3'UTR luciferase reporter plasmid: TRIM27 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM27 (see all 7)
    OriGene shRNA RFP: TRIM27
    OriGene siRNA: TRIM27
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM27

    Additional cDNA sequence: 

    AF230393.1 AF230394.1 AJ420519.1 BC013580.1 BC066924.1 J03407.1 

    11 DOTS entries:

    DT.65286447  DT.40123394  DT.97855071  DT.97855070  DT.100807109  DT.206399  DT.95280354  DT.100807098 
    DT.121317327  DT.40267798  DT.91975851 

    24/426 AceView cDNA sequences (see all 426):

    BE327539 AL562616 AA583069 AW157678 BQ065292 AA496558 BQ063801 BI771020 
    AA583188 BQ186498 CA310946 BQ064504 BQ420343 AA737429 CA307523 F09030 
    BM717914 AA451843 BE394000 BM854440 BQ062362 BQ054222 H79765 AA987771 

    GeneLoc Exon Structure


    Expression
    for TRIM27 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGGTTCTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TRIM27 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Long-time differentiated EBs (Derivation of embryo...)
    Short-term differentiated embryoid bodies (Derivation of embryo...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TRIM27 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM27

    SOURCE GeneReport for Unigene cluster: Hs.440382

    UniProtKB/Swiss-Prot: TRI27_HUMAN, P14373
    Tissue specificity: Expressed in testis namely within the seminiferous tubules

        SABiosciences Expression via Pathway-Focused PCR Arrays including TRIM27: 
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              Epigenetic Chromatin Remodeling Factors in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for TRIM27 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM27 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TRIM271 tripartite motif containing 27 56.91(n)
    43.01(a)    		   425772  NM_001099354.1  NP_001092824.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 33)    		 --
    		 40(a)
    38(a)
    (see all 33)    		 possible ortholog
    possible ortholog
    (see all 33)    		 2(188851296-188862893)
    2(195875107-195885372)
    zebrafish
    (Danio rerio)    		 Actinopterygii trim476
    		 tripartite motif containing 47
    		 27(a)
    		 possible ortholog
    		 10(26752552-26762609)


    ENSEMBL Gene Tree for TRIM27 (if available)
    TreeFam Gene Tree for TRIM27 (if available) 

    Paralogs
    for TRIM27 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM27 gene
    TRIM42  TRIM72  TRIM262  TRIM392  TRIM342  TRIML12  TRIM582  TRIM682  
    TRIM102  TRIM152  TRIM602  TRIM222  TRIM172  TRIM52  TRIM62  TRIM6-TRIM342  
    TRIM212  TRIM382  TRIM39-RPP212  TRIM112  
    18/57 SIMAP similar genes for TRIM27 using alignment to 7 protein entries:     TRI27_HUMAN (see all proteins) (see all similar genes):
    ERMAP    BTN1A1    BTN2A2    FLJ00123    BTNL3    TRIM39
    BTNL8    TRIM69    MEFV    DKFZp666N1710    TRIM68    TRIM11
    TRIM21    TRIM41    BTN3A3    TRIM31    RFPL3    TRIM5

    TRIM27 for paralogs           About GeneDecksing



    Genomic Variants
    for TRIM27 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/436 NCBI SNPs in TRIM27 are shown (see all 436)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2019266051,2
    		C--28684226(-) TTAATA/C/G/T 
                AATCC     		1 -- int10--------
    rs1131744791,2
    		C,--28870340(+) GTCAGG/AAGTTC 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs2091271,2
    		C,F,--28870391(-) TTTTTG/ATTTTT 1 -- ds50014Minor allele frequency- A:0.25WA NA 8
    rs1414367641,2
    		--28870496(+) GAGCCA/GAGATC 1 -- ds50010--------
    rs1917074241,2
    		--28870519(+) TCTAGA/GCTGGG 1 -- ds50010--------
    rs1835382461,2
    		--28870566(+) TGTAGC/GCTATG 1 -- ds50010--------
    rs1451848091,2
    		--28870656(+) AGTAAA/GCTATT 1 -- ds50010--------
    rs1378804021,2
    		--28870802(+) TTATTA/TTTAAA 1 -- ut310--------
    rs10560651,2
    		C--28870843(-) TGGTTC/TTCAGT 1 -- ut31 ese31Minor allele frequency- T:0.00NA 2
    rs412706041,2
    		C,--28870847(+) AGAACC/TATCAT 1 -- ut312Minor allele frequency- T:0.07NA WA 120

    HapMap Linkage Disequilibrium report for TRIM27 (28870779 - 28891768 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TRIM27: --

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    Disorders / Diseases
    for TRIM27 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRIM27 for disorders           About GeneDecksing

    OMIM gene information: 602165    OMIM disorders: --

    UniProtKB/Swiss-Prot: TRI27_HUMAN, P14373
  • Defects in TRIM27 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the
    • thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary
    carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of
    fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration
    involving TRIM27/RFP is found in thyroid papillary carcinomas. Translocation t(6;10)(p21.3;q11.2) with RET. The
    translocation generates TRIM27/RET and delta TRIM27/RET oncogenes

    20 diseases for TRIM27:    About MalaCards
    familial mediterranean fever    testicular germ cell tumor    germ cell tumor    systemic lupus erythematosus
    lupus erythematosus    papillary thyroid carcinoma    macular degeneration    chronic lymphocytic leukemia
    lymphocytic leukemia    squamous cell carcinoma    thyroid carcinoma    hemochromatosis
    shigellosis    endometrial cancer    leukemia    thyroiditis
    carcinoma    retinoblastoma    breast carcinoma    ataxia

    2 Novoseek disease relationships for TRIM27 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    promyelocytic leukemia 50 1 9023983 (1)
    leukemia 2.7 2 2112113 (1)

    Human Genome Epidemiology (HuGE) Navigator: TRIM27 (2 documents)

    Export disorders for TRIM27 gene to outside databases

    Publications
    for TRIM27 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM27 gene, integrated from 9 sources (see all 65):
    (articles sorted by number of sources associating them with TRIM27)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The Ret finger protein induces apoptosis via its RING finger-B box- coiled-coil motif. (PubMed id 12807881)1, 2, 9 Dho S.H. and Kwon K.S. (2003)
    2. RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions. (PubMed id 10976108)1, 2, 9 Shimono Y.... Takahashi M. (2000)
    3. Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML. (PubMed id 9570750)1, 2, 9 Cao T.... Etkin L.D. (1998)
    4. Involvement of the rfp tripartite motif in protein-protein interactions and subcellular distribution. (PubMed id 9247190)1, 2, 9 Cao T.... Etkin L.D. (1997)
    5. Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities. (PubMed id 14530259)1, 2, 9 Shimono Y....Takahashi M. (2003)
    6. Selective ablation of retinoblastoma protein function by the RET finger protein. (PubMed id 15837424)1, 2, 9 Krutzfeldt M.... Mittnacht S. (2005)
    7. Novel tumorigenic rearrangement, Delta rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient. (PubMed id 12787916)1, 2, 9 Saenko V.... Yamashita S. (2003)
    8. Differential expression of RET finger protein in testicular germ cell tumors. (PubMed id 12445133)1, 2, 9 Tezel G.... Takahashi M. (2002)
    9. Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies. (PubMed id 10504338)1, 2, 9 Morris-Desbois C.... Jalinot P. (1999)
    10. Tripartite motif containing protein 27 negatively reg ulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2I^. (PubMed id 22128329)1, 2 Cai X....Skolnik E.Y. (2011)

    External Searches for TRIM27 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing TRIM27 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5987 HGNC: 9975 AceView: RFP Ensembl:ENSG00000204713 euGenes: HUgn5987
    ECgene: TRIM27 H-InvDB: TRIM27

    Other Databases showing TRIM27 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TRIM27 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM27 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TRIM27 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TRIM27 gene:
    Search GeneIP for patents involving TRIM27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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