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Aliases for TRIM26 Gene

Aliases for TRIM26 Gene

  • Tripartite Motif Containing 26 2 3 5
  • Tripartite Motif-Containing 26 2 3
  • Zinc Finger Protein 173 3 4
  • RING Finger Protein 95 3 4
  • Acid Finger Protein 3 4
  • ZNF173 3 4
  • RNF95 3 4
  • AFP 3 4
  • Widely Expressed Acid Zinc Finger Protein 3

External Ids for TRIM26 Gene

Previous HGNC Symbols for TRIM26 Gene

  • ZNF173

Previous GeneCards Identifiers for TRIM26 Gene

  • GC06M030236
  • GC06M029922
  • GC06M030258
  • GC06M030260
  • GC06M030152
  • GC06M029951

Summaries for TRIM26 Gene

Entrez Gene Summary for TRIM26 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for TRIM26 Gene

TRIM26 (Tripartite Motif Containing 26) is a Protein Coding gene. Diseases associated with TRIM26 include Neural Tube Defects and Seizure Disorder. Among its related pathways are Immune System and Interferon gamma signaling. An important paralog of this gene is TRIM58.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM26 Gene

Genomics for TRIM26 Gene

Regulatory Elements for TRIM26 Gene

Enhancers for TRIM26 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM26 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM26 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM26 Gene

30,184,453 bp from pter
30,213,494 bp from pter
29,042 bases
Minus strand

Genomic View for TRIM26 Gene

Genes around TRIM26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TRIM26 Gene

  • Protein details for TRIM26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 26
    Protein Accession:
    Secondary Accessions:
    • A6NG96
    • Q5SRL2

    Protein attributes for TRIM26 Gene

    539 amino acids
    Molecular mass:
    62166 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM26 Gene

Proteomics data for TRIM26 Gene at MOPED

Post-translational modifications for TRIM26 Gene

  • Ubiquitination at Lys 245 and Lys 449
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM26 Gene

No data available for DME Specific Peptides for TRIM26 Gene

Domains & Families for TRIM26 Gene

Gene Families for TRIM26 Gene

Suggested Antigen Peptide Sequences for TRIM26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM26: view

Function for TRIM26 Gene

genes like me logo Genes that share phenotypes with TRIM26: view

Animal Model Products

miRNA for TRIM26 Gene

miRTarBase miRNAs that target TRIM26

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM26 Gene

Localization for TRIM26 Gene

Subcellular locations from

Jensen Localization Image for TRIM26 Gene COMPARTMENTS Subcellular localization image for TRIM26 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TRIM26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TRIM26: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM26 Gene

Pathways & Interactions for TRIM26 Gene

genes like me logo Genes that share pathways with TRIM26: view

Pathways by source for TRIM26 Gene

Gene Ontology (GO) - Biological Process for TRIM26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response IDA 18248090
GO:0060333 interferon-gamma-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with TRIM26: view

No data available for SIGNOR curated interactions for TRIM26 Gene

Drugs & Compounds for TRIM26 Gene

No Compound Related Data Available

Transcripts for TRIM26 Gene

Unigene Clusters for TRIM26 Gene

Tripartite motif containing 26:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM26 Gene

No ASD Table

Relevant External Links for TRIM26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM26 Gene

mRNA expression in normal human tissues for TRIM26 Gene

Protein differential expression in normal tissues from HIPED for TRIM26 Gene

This gene is overexpressed in Pancreas (8.6), NK cells (7.1), Peripheral blood mononuclear cells (6.6), and CD8 Tcells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM26 Gene

SOURCE GeneReport for Unigene cluster for TRIM26 Gene Hs.731863

genes like me logo Genes that share expression patterns with TRIM26: view

Protein tissue co-expression partners for TRIM26 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIM26 Gene

Orthologs for TRIM26 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM26 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIM26 35
  • 92.15 (n)
  • 94.25 (a)
TRIM26 36
  • 93 (a)
(Canis familiaris)
Mammalia TRIM26 35
  • 84.91 (n)
  • 88.87 (a)
TRIM26 36
  • 95 (a)
(Mus musculus)
Mammalia Trim26 35
  • 85.28 (n)
  • 88.87 (a)
Trim26 16
Trim26 36
  • 88 (a)
(Pan troglodytes)
Mammalia TRIM26 35
  • 99.26 (n)
  • 99.81 (a)
TRIM26 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Trim26 35
  • 84.29 (n)
  • 87.76 (a)
(Monodelphis domestica)
Mammalia TRIM26 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
-- 36
  • 42 (a)
Species with no ortholog for TRIM26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM26 Gene

Gene Tree for TRIM26 (if available)
Gene Tree for TRIM26 (if available)

Paralogs for TRIM26 Gene

genes like me logo Genes that share paralogs with TRIM26: view

Variants for TRIM26 Gene

Sequence variations from dbSNP and Humsavar for TRIM26 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs17194565 - 30,196,690(+) AGGAA(A/C)TGATG intron-variant, reference, missense
rs1042338 -- 30,185,012(-) TGACC(A/G)GGTTC utr-variant-3-prime
rs1042398 -- 30,184,668(+) CGGCT(A/C/G/T)TGGGC utr-variant-3-prime
rs1060914 -- 30,204,541(+) AACCT(A/C/G/T)ATTTC intron-variant
rs1060916 -- 30,204,145(-) AAGGG(A/G)AGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM26 Gene

Variant ID Type Subtype PubMed ID
esv2731777 CNV Deletion 23290073

Variation tolerance for TRIM26 Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.55% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRIM26 Gene

Disorders for TRIM26 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TRIM26 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neural tube defects
  • spina bifida
seizure disorder
  • epilepsy
  • pineal germinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIM26

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRIM26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM26 Gene

Publications for TRIM26 Gene

  1. Cloning of a new 'finger' protein gene (ZNF173) within the class I region of the human MHC. (PMID: 8530076) Chu T.W. … Gruen J.R. (Genomics 1995) 2 3 4 23 67
  2. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  3. TRIM26 negatively regulates interferon-I^ production and antiviral response through polyubiquitination and degradation of nuclear IRF3. (PMID: 25763818) Wang P. … Gao C. (PLoS Pathog. 2015) 3
  4. TRIM26 functions as a novel tumor suppressor of hepatocellular carcinoma and its downregulation contributes to worse prognosis. (PMID: 26043685) Wang Y. … He D. (Biochem. Biophys. Res. Commun. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for TRIM26 Gene

Sources for TRIM26 Gene