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Aliases for TRIM26 Gene

Aliases for TRIM26 Gene

  • Tripartite Motif Containing 26 2 3
  • ZNF173 3 4 6
  • Tripartite Motif-Containing 26 2 3
  • Zinc Finger Protein 173 3 4
  • RING Finger Protein 95 3 4
  • Acid Finger Protein 3 4
  • RNF95 3 4
  • AFP 3 4
  • Widely Expressed Acid Zinc Finger Protein 3
  • Tripartite Motif-Containing Protein 26 3

External Ids for TRIM26 Gene

Previous HGNC Symbols for TRIM26 Gene

  • ZNF173

Previous GeneCards Identifiers for TRIM26 Gene

  • GC06M030236
  • GC06M029922
  • GC06M030258
  • GC06M030260
  • GC06M030152
  • GC06M029951

Summaries for TRIM26 Gene

Entrez Gene Summary for TRIM26 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for TRIM26 Gene

TRIM26 (Tripartite Motif Containing 26) is a Protein Coding gene. Diseases associated with TRIM26 include endodermal sinus tumor and seizure disorder. Among its related pathways are Hippo signaling pathway and Glucocorticoid receptor regulatory network. An important paralog of this gene is TRIM50.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM26 Gene

Genomics for TRIM26 Gene

Regulatory Elements for TRIM26 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIM26 Gene

30,184,455 bp from pter
30,213,494 bp from pter
29,040 bases
Minus strand

Genomic View for TRIM26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TRIM26 Gene

  • Protein details for TRIM26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 26
    Protein Accession:
    Secondary Accessions:
    • A6NG96
    • Q5SRL2

    Protein attributes for TRIM26 Gene

    539 amino acids
    Molecular mass:
    62166 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM26 Gene

Proteomics data for TRIM26 Gene at MOPED

Post-translational modifications for TRIM26 Gene

  • Ubiquitination at Lys245 and Lys449
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM26 Gene

Antibody Products

No data available for DME Specific Peptides for TRIM26 Gene

Domains for TRIM26 Gene

Suggested Antigen Peptide Sequences for TRIM26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM26: view

Function for TRIM26 Gene

Gene Ontology (GO) - Molecular Function for TRIM26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 8530076
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding NAS 8530076
genes like me logo Genes that share ontologies with TRIM26: view

Phenotypes for TRIM26 Gene

genes like me logo Genes that share phenotypes with TRIM26: view

Animal Model Products

miRNA for TRIM26 Gene

miRTarBase miRNAs that target TRIM26

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM26

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM26 Gene

Localization for TRIM26 Gene

Subcellular locations from

Jensen Localization Image for TRIM26 Gene COMPARTMENTS Subcellular localization image for TRIM26 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TRIM26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRIM26: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM26 Gene

Pathways for TRIM26 Gene

genes like me logo Genes that share pathways with TRIM26: view

Pathways by source for TRIM26 Gene

1 Cell Signaling Technology pathway for TRIM26 Gene
1 KEGG pathway for TRIM26 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TRIM26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0045087 innate immune response IDA 18248090
GO:0046597 negative regulation of viral entry into host cell IDA 18248090
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IDA 23077300
GO:0060333 interferon-gamma-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with TRIM26: view

Transcripts for TRIM26 Gene

Unigene Clusters for TRIM26 Gene

Tripartite motif containing 26:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM26

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM26 Gene

No ASD Table

Relevant External Links for TRIM26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM26 Gene

mRNA expression in normal human tissues for TRIM26 Gene

Protein differential expression in normal tissues for TRIM26 Gene

This gene is overexpressed in Pancreas (8.6), NK cells (7.1), Peripheral blood mononuclear cells (6.6), and CD8 Tcells (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRIM26 Gene

SOURCE GeneReport for Unigene cluster for TRIM26 Gene Hs.731863

genes like me logo Genes that share expressions with TRIM26: view

Expression partners for TRIM26 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIM26 Gene

Orthologs for TRIM26 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM26 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIM26 35
  • 92.15 (n)
  • 94.25 (a)
TRIM26 36
  • 93 (a)
(Canis familiaris)
Mammalia TRIM26 35
  • 84.91 (n)
  • 88.87 (a)
TRIM26 36
  • 95 (a)
(Mus musculus)
Mammalia Trim26 35
  • 85.28 (n)
  • 88.87 (a)
Trim26 16
Trim26 36
  • 88 (a)
(Pan troglodytes)
Mammalia TRIM26 35
  • 99.26 (n)
  • 99.81 (a)
TRIM26 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Trim26 35
  • 84.29 (n)
  • 87.76 (a)
(Monodelphis domestica)
Mammalia TRIM26 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
-- 36
  • 42 (a)
Species with no ortholog for TRIM26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM26 Gene

Gene Tree for TRIM26 (if available)
Gene Tree for TRIM26 (if available)

Paralogs for TRIM26 Gene

genes like me logo Genes that share paralogs with TRIM26: view

Variants for TRIM26 Gene

Sequence variations from dbSNP and Humsavar for TRIM26 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs7843 -- 30,184,590(-) TCACA(C/T)GTACA utr-variant-3-prime
rs11158 -- 30,184,690(-) CTGTT(A/C/T)TAAGA utr-variant-3-prime
rs718254 -- 30,191,262(-) AGCAT(C/G)TCAGA intron-variant
rs736465 -- 30,196,125(-) GAGGG(A/G)GGGCT intron-variant
rs765977 -- 30,189,877(+) CAGAA(A/G)GGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM26 Gene

Variant ID Type Subtype PubMed ID
esv2731777 CNV Deletion 23290073

Relevant External Links for TRIM26 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM26 Gene

Disorders for TRIM26 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TRIM26 Gene in MalaCards »

(2) Diseases for TRIM26 Gene

Relevant External Links for TRIM26

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TRIM26: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TRIM26 Gene

Publications for TRIM26 Gene

  1. Cloning of a new 'finger' protein gene (ZNF173) within the class I region of the human MHC. (PMID: 8530076) Chu T.W. … Gruen J.R. (Genomics 1995) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genome-wide association study identifies five new schizophrenia loci. (PMID: 21926974) (Nat. Genet. 2011) 3 48
  4. A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. (PMID: 20593013) Cree B.A. … . (PLoS ONE 2010) 3 48
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 48

Products for TRIM26 Gene

Sources for TRIM26 Gene

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