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TRIM26 Gene

protein-coding   GIFtS: 50
GCID: GC06M030152

Tripartite Motif Containing 26

(Previous name: tripartite motif-containing 26)
(Previous symbol: ZNF173)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 261 2     AFP2 3
ZNF1731 2 3 5     RNF952 3
Tripartite Motif-Containing 261 2     RING Finger Protein 952 3
Acid Finger Protein2 3     Tripartite Motif-Containing Protein 262
Zinc Finger Protein 1732 3     Widely Expressed Acid Zinc Finger Protein2

External Ids:    HGNC: 129621   Entrez Gene: 77262   Ensembl: ENSG000002341277   OMIM: 6008305   UniProtKB: Q128993   

Export aliases for TRIM26 gene to outside databases

Previous GC identifers: GC06M030236 GC06M029922 GC06M030258 GC06M030260 GC06M029951


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIM26 Gene:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes
to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein
may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on
chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
(provided by RefSeq, Jun 2011)

GeneCards Summary for TRIM26 Gene:
TRIM26 (tripartite motif containing 26) is a protein-coding gene. Diseases associated with TRIM26 include endodermal sinus tumor, and seizure disorder. An important paralog of this gene is TRIM31.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM26 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   Nkx2-5   LCR-F1   E2F-1   E2F   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM26 promoter sequence
   Search Chromatin IP Primers for TRIM26

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21.3

TRIM26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM26 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M030152:  view genomic region     (about GC identifiers)

Start:
30,152,232 bp from pter      End:
30,181,271 bp from pter
Size:
29,040 bases      Orientation:
minus strand

Selected alternative locations (see all 7):
Chr6-,NT_167244 1,392,422-1,421,465      Chr6-,NT_113891.2 1,664,341-1,693,371      Chr6-,NT_167245 1,445,912-1,474,955     
Chr6-,NT_167248 1,445,147-1,474,192      Chr6-,NT_167247 1,534,069-1,562,952      Chr6-,NT_167246 1,500,731-1,529,767     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRI26_HUMAN, Q12899 (See protein sequence)
Recommended Name: Tripartite motif-containing protein 26  
Size: 539 amino acids; 62166 Da
Secondary accessions: A6NG96 Q5SRL2

Explore the universe of human proteins at neXtProt for TRIM26: NX_Q12899

Explore proteomics data for TRIM26 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys245, Lys449
  • Modification sites at PhosphoSitePlus

  • See TRIM26 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001229712.1  NP_003440.1  

    ENSEMBL proteins: 
     ENSP00000395491   ENSP00000410446   ENSP00000391879   ENSP00000413673   ENSP00000387530  
     ENSP00000400920  

    TRIM26 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TRIM26
    OriGene Protein Over-expression Lysate for TRIM26
    OriGene MassSpec for TRIM26
    OriGene Custom Protein Services for TRIM26
    GenScript Custom Purified and Recombinant Proteins Services for TRIM26
    Novus Biologicals TRIM26 Proteins
    Novus Biologicals TRIM26 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIM26

    TRIM26 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TRIM26
    Novus Biologicals TRIM26 Antibodies
    Abcam antibodies for TRIM26
    Cloud-Clone Corp. Antibodies for TRIM26
    Search ThermoFisher Antibodies for TRIM26
    LSBio Antibodies in human, mouse, rat for TRIM26

    TRIM26 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRIM26
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRIM26
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRIM26
    Cloud-Clone Corp. CLIAs for TRIM26


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 9):
     IPR006574 PRY
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt
     IPR000315 Znf_B-box

    Graphical View of Domain Structure for InterPro Entry Q12899

    ProtoNet protein and cluster: Q12899

    4 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: TRI26_HUMAN, Q12899
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    TRIM26 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS8530076
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding NAS8530076
         
    TRIM26 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRIM26:
     Increased Salmonella enterica   Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM26
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRIM26

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM26
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM26

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRIM26:
    hsa-mir-1 (MIRT023586)

    Block miRNA regulation of human, mouse, rat TRIM26 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TRIM26:
    hsa-miR-27b* hsa-miR-571 hsa-miR-510 hsa-miR-107 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidTRIM26 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRIM26
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM26

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRIM26

    Clone
    Products:
         
    OriGene clones in human, mouse for TRIM26 (see all 7)
    OriGene ORF clones in mouse, rat for TRIM26
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIM26 (NM_003449)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM26
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM26

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRIM26
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRIM26 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM26


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular ----
    GO:0005737cytoplasm IEA--

    TRIM26 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM26: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TRIM26

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for TRIM26 (Q128993 ENSP000003918794) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D1P516683, ENSP000003630194I2D: score=2 STRING: ENSP00000363019
    UBE2D3P610773I2D: score=2 
    CEBPDP497163I2D: score=1 
    MAGEA6P433603I2D: score=1 
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    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ----
    GO:0045087innate immune response IDA18248090
    GO:0046597negative regulation of viral entry into host cell IDA18248090
    GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity IDA--
    GO:1902187negative regulation of viral release from host cell IDA18248090

    TRIM26 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM26 (TRI26)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRIM26 gene (2 alternative transcripts): 
    NM_001242783.1  NM_003449.4  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480999 ENST00000437089(uc003npr.3) ENST00000454678(uc003nps.3 uc010jry.3)
    ENST00000453195(uc003npt.3) ENST00000416596(uc003npu.1) ENST00000418026
    ENST00000434785 ENST00000487829
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRIM26 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TRIM26:
    hsa-miR-27b* hsa-miR-571 hsa-miR-510 hsa-miR-107 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidTRIM26 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRIM26
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM26
    Clone
    Products:
         
    OriGene clones in human, mouse for TRIM26 (see all 7)
    OriGene ORF clones in mouse, rat for TRIM26
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIM26 (NM_003449)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM26
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM26
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRIM26
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM26
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM26
      QuantiTect SYBR Green Assays in human, mouse, rat TRIM26
      QuantiFast Probe-based Assays in human, mouse, rat TRIM26

    Selected AceView cDNA sequences (see all 226):

    BI906732 BM479784 AA318703 AI076266 BQ946494 BC021115 BQ669195 AW005938 
    AA399169 BU857551 BQ882190 AI198137 BQ899355 BQ055162 BU538658 CB112900 
    AA463352 BC032297 BU944679 H69622 BQ712113 AL702483 AI765095 BM717724 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACCTAGTG
    TRIM26 Expression
    About this image

    TRIM26 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM26 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM26: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TRIM26
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM26
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM26
    QuantiTect SYBR Green Assays in human, mouse, rat TRIM26
    QuantiFast Probe-based Assays in human, mouse, rat TRIM26
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM26

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for TRIM26 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim261 , 5 tripartite motif-containing 261, 5 85.28(n)1
    88.87(a)1
      17 (19.16 cM)5
    226701  NM_001286727.11  NP_001273656.11 
     368371345 


    ENSEMBL Gene Tree for TRIM26 (if available)
    TreeFam Gene Tree for TRIM26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM26 gene
    TRIM312  TRIM502  TRIM102  TRIM732  TRIM692  TRIM152  TRIM742  TRIM352  
    TRIM522  TRIM412  TRIM622  TRIM722  
    Selected SIMAP similar genes for TRIM26 using alignment to 5 protein entries:     TRI26_HUMAN (see all proteins) (see all similar genes):
    TRIM39    TRIM60    TRIM8    TRIM68    TRIM5    BRCA1
    TRIM22    TRIM41    RFPL1    RNF112    TRIM31    TRIM10
    TRIM61    TRIM35    TRIM48    TRIM21    TRIM69    TRIM25

    TRIM26 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for TRIM26 (see all 7)
    PGOHUM00000243569 PGOHUM00000235933 PGOHUM00000245396 PGOHUM00000236875 PGOHUM00000243010


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM26 (see all 750)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs74539371,2
    C--30065900(+) atggcA/Gccact 2 -- ds50010--------
    rs132153071,2
    C,F--30151954(+) CAAAAC/TGCTGG 2 -- ds50016Minor allele frequency- T:0.03NA 266
    rs1929886951,2
    --30152030(+) GTTCCA/GCAGTA 2 -- ds50010--------
    rs93667541,2
    C,F,H--30152033(+) CCGCAG/CTAGGC 2 -- ds500127Minor allele frequency- C:0.18EA NA NS 3176
    rs801506681,2
    C,F--30152048(+) TTTGAG/CGGACT 2 -- ds50011Minor allele frequency- C:0.05WA 118
    rs22395301,2
    C,F,A,H--30152115(+) AGGCAC/GAGAAG 2 -- ds500113Minor allele frequency- G:0.19EA NS NA 2152
    rs1152546491,2
    C,F--30152130(+) ACCTTC/TGGCTA 2 -- ds50011Minor allele frequency- T:0.02NA 120
    rs597953451,2
    C,F--30152201(+) ATAGAT/CATAGA 2 -- ds50012Minor allele frequency- C:0.04WA NA 238
    rs1477074971,2
    C--30152364(+) AGATGG/TACATG 2 -- ut310--------
    rs78431,2
    C,F,A,H--30152367(-) TCACAT/CGTACA 2 -- ut3126Minor allele frequency- C:0.17MN EA NA NS CSA 4118

    HapMap Linkage Disequilibrium report for TRIM26 (30152232 - 30181271 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TRIM26:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731777CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM26
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM26

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600830    OMIM disorders: --

    12 diseases for TRIM26:    
    About MalaCards
    endodermal sinus tumor    seizure disorder    germinoma    sinusitis
    neural tube defects    brain cancer    multiple sclerosis    schizophrenia
    systemic lupus erythematosus    hepatitis c    lupus erythematosus    hepatitis


    TRIM26 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRIM26
    Human Genome Epidemiology (HuGE) Navigator: TRIM26 (3 documents)

    Export disorders for TRIM26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM26 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with TRIM26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a new 'finger' protein gene (ZNF173) within the class I region of the human MHC. (PubMed id 8530076)1, 2, 3, 9 Chu T.W.... Gruen J.R. (Genomics 1995)
    2. Genome-wide association study identifies five new schizophrenia loci. (PubMed id 21926974)1, 4 (Nat. Genet. 2011)
    3. A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. (PubMed id 20593013)1, 4 Cree B.A.... . (PLoS ONE 2010)
    4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    7. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. (PubMed id 23453885)1 (Lancet 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes. (PubMed id 22433715)1 de Jong S....Ophoff R.A. (Eur. J. Hum. Genet. 2012)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7726 HGNC: 12962 AceView: TRIM26 Ensembl:ENSG00000234127 euGenes: HUgn7726
    ECgene: TRIM26 H-InvDB: TRIM26

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRIM26 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRIM26 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM26 gene:
    Search GeneIP for patents involving TRIM26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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