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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM25 Gene

protein-coding   GIFtS: 62
GCID: GC17M054965

Tripartite Motif Containing 25

(Previous names: zinc finger protein 147 (estrogen-responsive finger protein),...)
(Previous symbol: ZNF147)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tripartite Motif Containing 251 2     RING Finger Protein 1472 3
ZNF1471 2 3 5     Z1472
EFP2 3 5     E3 Ubiquitin/ISG15 Ligase TRIM252
Tripartite Motif-Containing 251 2     Tripartite Motif Protein TRIM252
Zinc Finger Protein 147 (Estrogen-Responsive Finger Protein)1 2     Zinc Finger Protein-1472
Estrogen-Responsive Finger Protein2 3     EC 6.3.2.193
Tripartite Motif-Containing Protein 252 3     EC 6.3.2.n33
Ubiquitin/ISG15-Conjugating Enzyme TRIM252 3     Zinc Finger Protein 1473
RNF1472 3     

External Ids:    HGNC: 129321   Entrez Gene: 77062   Ensembl: ENSG000001210607   OMIM: 6004535   UniProtKB: Q142583   

Export aliases for TRIM25 gene to outside databases

Previous GC identifers: GC17M055444 GC17M052323 GC17M050325


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRIM25 Gene:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes
to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that
this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression
of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast
cancer as a primary response gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRIM25 Gene: 
TRIM25 (tripartite motif containing 25) is a protein-coding gene. Diseases associated with TRIM25 include breast cancer, and endometrial carcinoma, and among its related super-pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Interferon Signaling. GO annotations related to this gene include ubiquitin-protein ligase activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TRIM29.

UniProtKB/Swiss-Prot: TRI25_HUMAN, Q14258
Function: Functions as an ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against
viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal
CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production
of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein
implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target
organs

Gene Wiki entry for TRIM25 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM25 gene promoter:
         AhR   STAT1   Pax-5   p53   Arnt   FOXJ2 (long isoform)   FOXJ2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TRIM25 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM25

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q23.1

TRIM25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM25 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M054965:  view genomic region     (about GC identifiers)

Start:
54,965,270 bp from pter      End:
54,991,409 bp from pter
Size:
26,140 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRI25_HUMAN, Q14258 (See protein sequence)
Recommended Name: E3 ubiquitin/ISG15 ligase TRIM25  
Size: 630 amino acids; 70973 Da
Subunit: Interacts (via SPRY domain) with DDX58 (via CARD domain). Interacts (via coiled coil) with influenza A
virus NS1 protein; this interaction specifically inhibits TRIM25 multimerization and TRIM25-mediated DDX58 CARD
ubiquitination, thereby suppressing DDX58 signal transduction
Subcellular location: Cytoplasm. Note=Colocalized with DDX58 at cytoplasmic perinuclear bodies

Explore the universe of human proteins at neXtProt for TRIM25: NX_Q14258

Explore proteomics data for TRIM25 at MOPED 

Post-translational modifications:

  • UniProtKB: Auto-ISGylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14258

  • TRIM25 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRIM25 Protein Expression
    REFSEQ proteins: NP_005073.2  
    ENSEMBL proteins: 
     ENSP00000323889   ENSP00000459980   ENSP00000445961  
    Reactome Protein details: Q14258
    Human Recombinant Protein Products for TRIM25: 
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    Novus Biologicals TRIM25 Proteins
    Novus Biologicals TRIM25 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIM25 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0030054cell junction IDA--

    TRIM25 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for TRIM25


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    5/9 InterPro protein domains (see all 9):
     IPR006574 PRY
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q14258

    ProtoNet protein and cluster: Q14258

    4 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: TRI25_HUMAN, Q14258
    Domain: The RING-type zinc finger is important for ISG15 E3 ligase activity and autoISGylation. AutoISGylation
    negatively regulates ISG15 E3 ligase activity
    Domain: The C-terminal B30.2/SPRY domain interacts with the first N-terminal CARD domain of DDX58
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    TRIM25 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI25_HUMAN, Q14258
    Function: Functions as an ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against
    viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal
    CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production
    of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein
    implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target
    organs
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine
    Catalytic activity: ATP + [ISG15] + [protein]-lysine = AMP + diphosphate + [protein]-N-ISGyllysine
    Induction: By interferons

         Enzyme Numbers (IUBMB): EC 6.3.2.191 EC 6.3.2.n31

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8248217
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding IPI19454348
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    TRIM25 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for TRIM25:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella-containin  Increased G1 DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Trim25):
     reproductive system 

    TRIM25 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Trim25tm1Mura for TRIM25

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRIM25 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRIM25

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM25 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM25 

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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM25 (see all 14):
    hsa-miR-3671 hsa-miR-345 hsa-miR-1283 hsa-miR-520d-5p hsa-miR-340 hsa-miR-544 hsa-miR-298 hsa-miR-2276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of TRIM25

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM25
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                         Customized lentivirus expression plasmids for stable overexpression of TRIM25 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM25


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRIM25 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.52
    Negative regulators of RIG-I/MDA5 signaling0.49
    RIG-I-like receptor signaling pathway0.52
    2Interferon Signaling
    Interferon Signaling0.61
    Antiviral mechanism by IFN-stimulated genes0.42
    Cytokine Signaling in Immune system0.61
    ISG15 antiviral mechanism0.42
    3Immune System
    Immune System0.56
    Innate Immune System0.50
    4TRAF6 mediated IRF7 activation
    TRAF6 mediated IRF7 activation0.45
    TRAF3-dependent IRF activation pathway0.45
    5RIP-mediated NFkB activation via ZBP1
    TRAF6 mediated NF-kB activation0.42
    NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -100.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for TRIM25
        NF-kappaB Signaling
    Protein Stability

    5/12        Reactome Pathways for TRIM25 (see all 12)
        NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
    Antiviral mechanism by IFN-stimulated genes
    Cytokine Signaling in Immune system
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    TRAF3-dependent IRF activation pathway


    3         Kegg Pathways  (Kegg details for TRIM25):
        NF-kappa B signaling pathway
    RIG-I-like receptor signaling pathway
    Influenza A

    UniProtKB/Swiss-Prot: TRI25_HUMAN, Q14258
    Pathway: Protein modification; protein ubiquitination


    TRIM25 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRIM25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for TRIM25 (Q142581, 3 ENSP000003238894) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319473, ENSP000003409894I2D: score=4 STRING: ENSP00000340989
    UBE2L6O149333, ENSP000002871564I2D: score=3 STRING: ENSP00000287156
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent TAS8248217
    GO:0019048modulation by virus of host morphology or physiology IEA--
    GO:0032480negative regulation of type I interferon production TAS--
    GO:0045087innate immune response TAS--
    GO:0051607defense response to virus IEA--

    TRIM25 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRIM25 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM25 (TRI25)

    3 Novoseek inferred chemical compound relationships for TRIM25 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atpa 71.3 2 17584914 (1), 16872520 (1)
    estrogen 62.7 88 7592654 (5), 10781795 (4), 9855000 (3), 16144914 (3) (see all 18)
    zinc 37.5 9 7789997 (2), 15178330 (1), 14978097 (1), 10425199 (1)

    Search CenterWatch for drugs/clinical trials and news about TRIM25 / TRI25

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRIM25 gene: 
    NM_005082.4  

    Unigene Cluster for TRIM25:

    Tripartite motif containing 25
    Hs.528952  [show with all ESTs]
    Unigene Representative Sequence: NM_005082
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316881(uc002iut.3 uc010dcj.3) ENST00000573108 ENST00000572021
    ENST00000574234 ENST00000570473 ENST00000570749 ENST00000572550 ENST00000574997
    ENST00000537230
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    hsa-miR-3671 hsa-miR-345 hsa-miR-1283 hsa-miR-520d-5p hsa-miR-340 hsa-miR-544 hsa-miR-298 hsa-miR-2276
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    Clone
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    Additional mRNA sequence: 

    AB208994.1 AK024597.1 AK310720.1 BC013752.1 BC016924.1 BC038247.2 BC042541.1 BC053605.1 
    BC106889.2 BC106890.2 BC114339.2 BX538220.1 D21205.1 

    11 DOTS entries:

    DT.100812467  DT.455205  DT.70105444  DT.100711025  DT.120948423  DT.91688982  DT.95210525  DT.121181434 
    DT.401976  DT.75172513  DT.97847280 

    24/332 AceView cDNA sequences (see all 332):

    AI244875 BM720114 AA252528 CF528455 CA311859 AI380996 AA304355 AI924823 
    AI336218 R88768 AI809930 BX956014 AA788722 CD369537 AI679744 Z38292 
    BC016924 BU753503 BQ010181 AV746032 BM826940 BM799254 BU838318 CA313579 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM25    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11
    SP1:              -                                         -           -                                       
    SP2:                                                                                                            
    SP3:                                                        -                                                   
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for TRIM25

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM25 expression in normal human tissues (normalized intensities)      TRIM25 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCACTGT
    TRIM25 Expression
    About this image


    TRIM25 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             neutrophils   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Midgut
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             ganglion/cranial   

    See TRIM25 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM25

    SOURCE GeneReport for Unigene cluster: Hs.528952

    UniProtKB/Swiss-Prot: TRI25_HUMAN, Q14258
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Arrays including TRIM25: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM25 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim251 , 5 tripartite motif-containing 251, 5 77.74(n)1
    74.44(a)1
      11 (54.34 cM)5
    2170691  NM_009546.21  NP_033572.21 
     889993765 
    chicken
    (Gallus gallus)
    Aves TRIM251 tripartite motif containing 25 59.58(n)
    49.84(a)
      417401  XM_415653.3  XP_415653.3 
    lizard
    (Anolis carolinensis)
    Reptilia TRIM256
    tripartite motif containing 25
    47(a)
    1 ↔ 1
    GL343198.1(658779-676108)
    zebrafish
    (Danio rerio)
    Actinopterygii BC045450.12   -- 73.88(n)   393144  BC045450.1 


    ENSEMBL Gene Tree for TRIM25 (if available)
    TreeFam Gene Tree for TRIM25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM25 gene
    TRIM292  TRIM16L2  TRIM472  TRIM162  TRIM652  TRIM82  
    2 SIMAP similar genes for TRIM25 using alignment to 4 protein entries:     TRI25_HUMAN (see all proteins):
    TRIM39    TRIM26

    TRIM25 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TRIM25
    PGOHUM00000237505


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/553 SNPs in TRIM25 are shown (see all 553)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1168106121,2
    C,F--54964857(+) AGTGAG/AGAAGA 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1156533791,2
    C,F--54964858(+) GTGAGG/AAAGAA 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1502392981,2
    --54964861(+) AGGAAG/TAAAAA 1 -- ds50010--------
    rs1389093741,2
    C--54964948(+) AAACTC/TAGGAG 1 -- ds50010--------
    rs25865211,2
    C,F,O,A,H--54964949(+) AACTCG/AGGAGG 1 -- ds500129Minor allele frequency- A:0.50NS EA NA WA CSA 2841
    rs1494813801,2
    --54965030(+) CCACCA/GCCTCT 1 -- ds50010--------
    rs1835507501,2
    --54965048(+) CACCAA/CCTGGT 1 -- ds50010--------
    rs1874800301,2
    --54965118(+) GGACAC/TAGTCC 1 -- ds50010--------
    rs1906666011,2
    --54965159(+) GCCCCA/CTGTGG 1 -- ds50010--------
    rs1459836661,2
    --54965162(+) CCATGG/TGGGGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TRIM25 (54965270 - 54991409 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TRIM25:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv32884CNV Loss17666407
    nsv524499CNV Loss19592680
    esv1004959CNV Gain20482838

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600453    OMIM disorders: --

    7 diseases for TRIM25:    About MalaCards
    breast cancer    endometrial carcinoma    influenza    ovarian cancer
    prostate cancer    prostatitis    endotheliitis


    TRIM25 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for TRIM25 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 34 13 16144914 (3), 10781795 (2), 15781984 (2), 12943693 (1)
    breast carcinoma 17.2 7 16144914 (6), 15644556 (1)
    tumors 6.33 8 12943693 (4), 10781795 (1), 9855000 (1), 16144914 (1)

    Genetic Association Database (GAD): TRIM25
    Human Genome Epidemiology (HuGE) Navigator: TRIM25 (1 document)

    Export disorders for TRIM25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM25 gene, integrated from 9 sources (see all 84):
    (articles sorted by number of sources associating them with TRIM25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosome mapping of human (ZNF147) and mouse genes for estrogen-responsive finger protein (efp), a member of the RING finger family. (PubMed id 7789997)1, 3, 9 Inoue S....Muramatsu M. (1995)
    2. Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein. (PubMed id 8248217)1, 2, 9 Inoue S.... Muramatsu M. (1993)
    3. Systemic distribution of estrogen-responsive finger protein (Efp) in human tissues. (PubMed id 15130519)1, 2, 9 Shimada N.... Sasano H. (2004)
    4. The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (2010)
    5. Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I. (PubMed id 19454348)1, 2 Gack M.U.... Garcia-Sastre A. (2009)
    6. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (2008)
    7. Negative regulation of ISG15 E3 ligase EFP through its autoISGylation. (PubMed id 17222803)1, 2 Zou W.... Zhang D.-E. (2007)
    8. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. (PubMed id 17392790)1, 2 Gack M.U....Jung J.U. (2007)
    9. A ubiquitin E3 ligase Efp is up-regulated by interferons and conjugated with ISG15. (PubMed id 17069755)1, 2 Nakasato N.... Inoue S. (2006)
    10. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7706 HGNC: 12932 AceView: TRIM25 Ensembl:ENSG00000121060 euGenes: HUgn7706
    ECgene: TRIM25 Kegg: 7706 H-InvDB: TRIM25

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM25 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRIM25 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/TRIM25

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRIM25 gene:
    Search GeneIP for patents involving TRIM25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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