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Aliases for TRIM25 Gene

Aliases for TRIM25 Gene

  • Tripartite Motif Containing 25 2 3
  • ZNF147 3 4 6
  • EFP 3 4 6
  • Zinc Finger Protein 147 (Estrogen-Responsive Finger Protein) 2 3
  • Ubiquitin/ISG15-Conjugating Enzyme TRIM25 3 4
  • Tripartite Motif-Containing Protein 25 3 4
  • Estrogen-Responsive Finger Protein 3 4
  • Tripartite Motif-Containing 25 2 3
  • RING Finger Protein 147 3 4
  • RNF147 3 4
  • E3 Ubiquitin/ISG15 Ligase TRIM25 3
  • Tripartite Motif Protein TRIM25 3
  • Zinc Finger Protein-147 3
  • Zinc Finger Protein 147 4
  • EC 6.3.2.19 4
  • EC 6.3.2.n3 4
  • Z147 3

External Ids for TRIM25 Gene

Previous HGNC Symbols for TRIM25 Gene

  • ZNF147

Previous GeneCards Identifiers for TRIM25 Gene

  • GC17M055444
  • GC17M052323
  • GC17M054965
  • GC17M050325

Summaries for TRIM25 Gene

Entrez Gene Summary for TRIM25 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM25 Gene

TRIM25 (Tripartite Motif Containing 25) is a Protein Coding gene. Diseases associated with TRIM25 include breast cancer. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and ubiquitin-protein transferase activity. An important paralog of this gene is TRIM16L.

UniProtKB/Swiss-Prot for TRIM25 Gene

  • Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates Lys-63-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.

Gene Wiki entry for TRIM25 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM25 Gene

Genomics for TRIM25 Gene

Regulatory Elements for TRIM25 Gene

Genomic Location for TRIM25 Gene

Start:
56,887,909 bp from pter
End:
56,914,048 bp from pter
Size:
26,140 bases
Orientation:
Minus strand

Genomic View for TRIM25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM25 Gene

Proteins for TRIM25 Gene

  • Protein details for TRIM25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14258-TRI25_HUMAN
    Recommended name:
    E3 ubiquitin/ISG15 ligase TRIM25
    Protein Accession:
    Q14258
    Secondary Accessions:

    Protein attributes for TRIM25 Gene

    Size:
    630 amino acids
    Molecular mass:
    70973 Da
    Quaternary structure:
    • Interacts (via SPRY domain) with DDX58 (via CARD domain). Interacts (via coiled coil) with influenza A virus NS1 protein; this interaction specifically inhibits TRIM25 multimerization and TRIM25-mediated DDX58 CARD ubiquitination, thereby suppressing DDX58 signal transduction.

    Three dimensional structures from OCA and Proteopedia for TRIM25 Gene

neXtProt entry for TRIM25 Gene

Proteomics data for TRIM25 Gene at MOPED

Post-translational modifications for TRIM25 Gene

  • Auto-ISGylated.
  • Ubiquitination at Lys117, Lys273, Lys320, Lys335, Lys439, Lys447, and Lys567
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM25 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM25 Gene

Domains for TRIM25 Gene

Gene Families for TRIM25 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Suggested Antigen Peptide Sequences for TRIM25 Gene

Graphical View of Domain Structure for InterPro Entry

Q14258

UniProtKB/Swiss-Prot:

TRI25_HUMAN :
  • Q14258
Domain:
  • The RING-type zinc finger is important for ISG15 E3 ligase activity and autoISGylation. AutoISGylation negatively regulates ISG15 E3 ligase activity
  • The C-terminal B30.2/SPRY domain interacts with the first N-terminal CARD domain of DDX58
  • Contains 1 B30.2/SPRY domain.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM25: view

Function for TRIM25 Gene

Molecular function for TRIM25 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine
UniProtKB/Swiss-Prot CatalyticActivity: ATP + [ISG15] + [protein]-lysine = AMP + diphosphate + [protein]-N-ISGyllysine
UniProtKB/Swiss-Prot Function: Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates Lys-63-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.
UniProtKB/Swiss-Prot Induction: By interferons.

Enzyme Numbers (IUBMB) for TRIM25 Gene

Gene Ontology (GO) - Molecular Function for TRIM25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 8248217
GO:0005515 protein binding IPI 19454348
GO:0008270 zinc ion binding IEA --
GO:0016881 acid-amino acid ligase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TRIM25: view
genes like me logo Genes that share phenotypes with TRIM25: view

Animal Models for TRIM25 Gene

MGI Knock Outs for TRIM25:

miRNA for TRIM25 Gene

miRTarBase miRNAs that target TRIM25

No data available for Transcription Factor Targeting and HOMER Transcription for TRIM25 Gene

Localization for TRIM25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM25 Gene

Cytoplasm. Note=Colocalized with DDX58 at cytoplasmic perinuclear bodies.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM25 Gene COMPARTMENTS Subcellular localization image for TRIM25 gene
Compartment Confidence
cytosol 4
nucleus 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRIM25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRIM25: view

Pathways for TRIM25 Gene

genes like me logo Genes that share pathways with TRIM25: view

UniProtKB/Swiss-Prot Q14258-TRI25_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIM25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0016032 viral process IEA --
GO:0016567 protein ubiquitination IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0019985 translesion synthesis TAS --
genes like me logo Genes that share ontologies with TRIM25: view

Compounds for TRIM25 Gene

(3) Novoseek inferred chemical compound relationships for TRIM25 Gene

Compound -log(P) Hits PubMed IDs
atpa 71.3 2
estrogen 62.7 39
zinc 37.5 5
genes like me logo Genes that share compounds with TRIM25: view

Transcripts for TRIM25 Gene

Unigene Clusters for TRIM25 Gene

Tripartite motif containing 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM25 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - - -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for TRIM25 Gene

GeneLoc Exon Structure for
TRIM25
ECgene alternative splicing isoforms for
TRIM25

Expression for TRIM25 Gene

mRNA expression in normal human tissues for TRIM25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM25 Gene

This gene is overexpressed in Whole Blood (12.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM25 Gene

SOURCE GeneReport for Unigene cluster for TRIM25 Gene Hs.528952

mRNA Expression by UniProt/SwissProt for TRIM25 Gene

Q14258-TRI25_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with TRIM25: view

Orthologs for TRIM25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRIM25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM25 35
  • 99.21 (n)
  • 98.73 (a)
TRIM25 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM25 35
  • 82.85 (n)
  • 77.16 (a)
TRIM25 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM25 35
  • 83.17 (n)
  • 78.04 (a)
TRIM25 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim25 35
  • 77.58 (n)
  • 74.12 (a)
Trim25 16
Trim25 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM25 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim25 35
  • 78.48 (n)
  • 74.24 (a)
chicken
(Gallus gallus)
Aves TRIM25 35
  • 58.87 (n)
  • 49.84 (a)
TRIM25 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM25 36
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii -- 35
trim25 35
  • 47.43 (n)
  • 35.93 (a)
trim25 36
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSH1 38
Species with no ortholog for TRIM25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM25 Gene

ENSEMBL:
Gene Tree for TRIM25 (if available)
TreeFam:
Gene Tree for TRIM25 (if available)

Paralogs for TRIM25 Gene

Paralogs for TRIM25 Gene

Selected SIMAP similar genes for TRIM25 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TRIM25 Gene

genes like me logo Genes that share paralogs with TRIM25: view

Variants for TRIM25 Gene

Sequence variations from dbSNP and Humsavar for TRIM25 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs7615 -- 56,888,571(-) GAGGG(C/T)TCATT utr-variant-3-prime
rs13917 -- 56,888,989(+) TACAG(A/C)CATGA utr-variant-3-prime
rs169530 -- 56,910,880(-) CCCTG(C/T)TACTG intron-variant
rs172230 -- 56,906,574(-) agagg(A/T)tgcag intron-variant
rs189973 -- 56,901,271(-) TCTGG(A/G)GGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM25 Gene

Variant ID Type Subtype PubMed ID
esv32884 CNV Loss 17666407
esv1004959 CNV Gain 20482838
nsv524499 CNV Loss 19592680

Relevant External Links for TRIM25 Gene

HapMap Linkage Disequilibrium report
TRIM25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM25 Gene

Disorders for TRIM25 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TRIM25 Gene including...

Search for TRIM25 Gene in MalaCards »

(3) Novoseek inferred disease relationships for TRIM25 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 34 8
breast carcinoma 17.2 7
tumors 6.33 7

Relevant External Links for TRIM25

Genetic Association Database (GAD)
TRIM25
Human Genome Epidemiology (HuGE) Navigator
TRIM25
genes like me logo Genes that share disorders with TRIM25: view

No data available for UniProtKB/Swiss-Prot for TRIM25 Gene

Publications for TRIM25 Gene

  1. Chromosome mapping of human (ZNF147) and mouse genes for estrogen-responsive finger protein (efp), a member of the RING finger family. (PMID: 7789997) Inoue S. … Muramatsu M. (Genomics 1995) 2 3 23
  2. Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein. (PMID: 8248217) Inoue S. … Muramatsu M. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4 23
  3. Systemic distribution of estrogen-responsive finger protein (Efp) in human tissues. (PMID: 15130519) Shimada N. … Sasano H. (Mol. Cell. Endocrinol. 2004) 3 4 23
  4. Efp as a primary estrogen-responsive gene in human breast cancer. (PMID: 10781795) Ikeda K. … Inoue S. (FEBS Lett. 2000) 3 23
  5. Estrogen-responsive RING finger protein controls breast cancer growth. (PMID: 12943693) Horie K. … Inoue S. (J. Steroid Biochem. Mol. Biol. 2003) 3 23

Products for TRIM25 Gene

Sources for TRIM25 Gene

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