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TRIM25 Gene

protein-coding   GIFtS: 63
GCID: GC17M054965

Tripartite Motif Containing 25

(Previous names: zinc finger protein 147 (estrogen-responsive finger protein),...)
(Previous symbol: ZNF147)
  See TRIM25-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 251 2     RING Finger Protein 1472 3
ZNF1471 2 3 5     Z1472
EFP2 3 5     E3 Ubiquitin/ISG15 Ligase TRIM252
Tripartite Motif-Containing 251 2     Tripartite Motif Protein TRIM252
Zinc Finger Protein 147 (Estrogen-Responsive Finger Protein)1 2     Zinc Finger Protein-1472
Estrogen-Responsive Finger Protein2 3     EC 6.3.2.193
Tripartite Motif-Containing Protein 252 3     EC 6.3.2.n33
Ubiquitin/ISG15-Conjugating Enzyme TRIM252 3     Zinc Finger Protein 1473
RNF1472 3     

External Ids:    HGNC: 129321   Entrez Gene: 77062   Ensembl: ENSG000001210607   OMIM: 6004535   UniProtKB: Q142583   

Export aliases for TRIM25 gene to outside databases

Previous GC identifers: GC17M055444 GC17M052323 GC17M050325


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIM25 Gene:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes
to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that
this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression
of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast
cancer as a primary response gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRIM25 Gene:
TRIM25 (tripartite motif containing 25) is a protein-coding gene. Diseases associated with TRIM25 include breast cancer. GO annotations related to this gene include ubiquitin-protein ligase activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ENSG00000251537.

UniProtKB/Swiss-Prot: TRI25_HUMAN, Q14258
Function: Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against
viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal
CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production
of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein
implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target
organs

Gene Wiki entry for TRIM25 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM25 gene promoter:
         AhR   STAT1   Pax-5   p53   Arnt   FOXJ2 (long isoform)   FOXJ2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TRIM25 promoter sequence
   Search Chromatin IP Primers for TRIM25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q23.1

TRIM25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM25 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M054965:  view genomic region     (about GC identifiers)

Start:
54,965,270 bp from pter      End:
54,991,409 bp from pter
Size:
26,140 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRI25_HUMAN, Q14258 (See protein sequence)
Recommended Name: E3 ubiquitin/ISG15 ligase TRIM25  
Size: 630 amino acids; 70973 Da
Subunit: Interacts (via SPRY domain) with DDX58 (via CARD domain). Interacts (via coiled coil) with influenza A
virus NS1 protein; this interaction specifically inhibits TRIM25 multimerization and TRIM25-mediated DDX58 CARD
ubiquitination, thereby suppressing DDX58 signal transduction

Explore the universe of human proteins at neXtProt for TRIM25: NX_Q14258

Explore proteomics data for TRIM25 at MOPED

Post-translational modifications: 

  • Auto-ISGylated1
  • Ubiquitination2 at Lys117, Lys273, Lys320, Lys335, Lys439, Lys447, Lys567
  • Modification sites at PhosphoSitePlus

  • See TRIM25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005073.2  
    ENSEMBL proteins: 
     ENSP00000323889   ENSP00000459980   ENSP00000445961  
    Reactome Protein details: Q14258

    TRIM25 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for TRIM25
    OriGene Protein Over-expression Lysate for TRIM25
    OriGene MassSpec for TRIM25
    OriGene Custom Protein Services for TRIM25
    GenScript Custom Purified and Recombinant Proteins Services for TRIM25
    Novus Biologicals TRIM25 Proteins
    Novus Biologicals TRIM25 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIM25

     
    Search eBioscience for Proteins for TRIM25 

    TRIM25 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for TRIM25 
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    Novus Biologicals TRIM25 Antibodies
    Abcam antibodies for TRIM25
    Cloud-Clone Corp. Antibodies for TRIM25
    ThermoFisher Antibodies for TRIM25
    LSBio Antibodies in human, mouse, rat for TRIM25

    TRIM25 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TRIM25
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRIM25
    Cloud-Clone Corp. CLIAs for TRIM25
    Search eBioscience for ELISAs for TRIM25 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 9):
     IPR006574 PRY
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q14258

    ProtoNet protein and cluster: Q14258

    4 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: TRI25_HUMAN, Q14258
    Domain: The RING-type zinc finger is important for ISG15 E3 ligase activity and autoISGylation. AutoISGylation
    negatively regulates ISG15 E3 ligase activity
    Domain: The C-terminal B30.2/SPRY domain interacts with the first N-terminal CARD domain of DDX58
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with TRIM25           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI25_HUMAN, Q14258
    Function: Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against
    viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal
    CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production
    of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein
    implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target
    organs
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine
    Catalytic activity: ATP + [ISG15] + [protein]-lysine = AMP + diphosphate + [protein]-N-ISGyllysine
    Induction: By interferons

         Enzyme Numbers (IUBMB): EC 6.3.2.191 EC 6.3.2.n31

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8248217
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding IPI19454348
    GO:0008270zinc ion binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with TRIM25           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for TRIM25:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella-containin  Increased G1 DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Trim25):
     reproductive system 

    Find genes that share phenotypes with TRIM25           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Trim25tm1Mura for TRIM25

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM25
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRIM25

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM25
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM25

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRIM25:
    hsa-mir-124-3p (MIRT022249), hsa-mir-877-3p (MIRT037080)

    Block miRNA regulation of human, mouse, rat TRIM25 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM25 (see all 14):
    hsa-miR-3671 hsa-miR-345 hsa-miR-1283 hsa-miR-520d-5p hsa-miR-340 hsa-miR-544 hsa-miR-298 hsa-miR-2276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRIM25
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM25

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRIM25

    Clone
    Products:
         
    OriGene clones in human, mouse for TRIM25 (see all 7)
    OriGene ORF clones in mouse, rat for TRIM25
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIM25 (NM_005082)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM25
    Addgene plasmids for TRIM25 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRIM25
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRIM25 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM25


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRI25_HUMAN, Q14258: Cytoplasm. Note=Colocalized with DDX58 at cytoplasmic perinuclear bodies
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0030054cell junction ----

    Find genes that share ontologies with TRIM25           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRIM25 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    TRAF6 mediated IRF7 activation0.40
    RIG-I-like receptor signaling pathway0.47
    TRAF3-dependent IRF activation pathway0.00
    Negative regulators of RIG-I/MDA5 signaling0.42
    NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -100.00
    2Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    3Cytosolic sensors of pathogen-associated DNA
    TRAF6 mediated NF-kB activation0.55
    4Influenza A
    Influenza A0.34
    5Protein Stability
    Protein Stability


    Find genes that share SuperPaths with TRIM25           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for TRIM25
        NF-kappaB Signaling
    Protein Stability

    Selected Reactome Pathways for TRIM25 (see all 7)
        NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
    TRAF3-dependent IRF activation pathway
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Negative regulators of RIG-I/MDA5 signaling
    TRAF6 mediated IRF7 activation


    3 Kegg Pathways  (Kegg details for TRIM25):
        NF-kappa B signaling pathway
    RIG-I-like receptor signaling pathway
    Influenza A

    UniProtKB/Swiss-Prot: TRI25_HUMAN, Q14258
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TRIM25: 

              Antiviral Response in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRIM25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRIM25 (Q142581, 3 ENSP000003238894) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319473, ENSP000003409894I2D: score=4 STRING: ENSP00000340989
    UBE2L6O149333, ENSP000002871564I2D: score=3 STRING: ENSP00000287156
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0032480negative regulation of type I interferon production TAS--
    GO:0033280response to vitamin D IEA--

    Find genes that share ontologies with TRIM25           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM25 (TRI25)

    3 Novoseek inferred chemical compound relationships for TRIM25 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atpa 71.3 2 17584914 (1), 16872520 (1)
    estrogen 62.7 88 7592654 (5), 10781795 (4), 9855000 (3), 16144914 (3) (see all 18)
    zinc 37.5 9 7789997 (2), 15178330 (1), 14978097 (1), 10425199 (1)



    Find genes that share compounds with TRIM25           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRIM25 gene: 
    NM_005082.4  

    Unigene Cluster for TRIM25:

    Tripartite motif containing 25
    Hs.528952  [show with all ESTs]
    Unigene Representative Sequence: NM_005082
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316881(uc002iut.3 uc010dcj.3) ENST00000573108 ENST00000572021
    ENST00000574234 ENST00000570473 ENST00000570749 ENST00000572550 ENST00000574997
    ENST00000537230
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRIM25 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM25 (see all 14):
    hsa-miR-3671 hsa-miR-345 hsa-miR-1283 hsa-miR-520d-5p hsa-miR-340 hsa-miR-544 hsa-miR-298 hsa-miR-2276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRIM25
    Clone
    Products:
         
    OriGene clones in human, mouse for TRIM25 (see all 7)
    OriGene ORF clones in mouse, rat for TRIM25
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIM25 (NM_005082)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM25
    Addgene plasmids for TRIM25 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRIM25
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM25
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM25
      QuantiTect SYBR Green Assays in human, mouse, rat TRIM25
      QuantiFast Probe-based Assays in human, mouse, rat TRIM25

    Additional mRNA sequence: 

    AB208994.1 AK024597.1 AK310720.1 BC013752.1 BC016924.1 BC038247.2 BC042541.1 BC053605.1 
    BC106889.2 BC106890.2 BC114339.2 BX538220.1 D21205.1 

    11 DOTS entries:

    DT.100812467  DT.455205  DT.70105444  DT.100711025  DT.120948423  DT.91688982  DT.95210525  DT.121181434 
    DT.401976  DT.75172513  DT.97847280 

    Selected AceView cDNA sequences (see all 332):

    BQ424771 AI336218 CR600776 AI244875 AI336267 CB306575 BU676440 AI744993 
    CF528455 AI924823 AA588258 BC042541 AI417069 CB306376 CD364770 AL550240 
    AA987574 BQ013212 CA311859 BU179956 CD369537 BE893188 AI276674 BM682019 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM25    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11
    SP1:              -                                         -           -                                       
    SP2:                                                                                                            
    SP3:                                                        -                                                   
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for TRIM25

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCACTGT
    TRIM25 Expression
    About this image


    TRIM25 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Thymus (Hematopoietic System)
             Thymus
     
     Lung (Respiratory System)
             Stem Bronchi
     
     Gut Tube (Gastrointestinal Tract)
             Midgut
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
    TRIM25 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM25 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.528952

    UniProtKB/Swiss-Prot: TRI25_HUMAN, Q14258
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TRIM25: 
              Antiviral Response in human mouse rat
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM25 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim251 , 5 tripartite motif-containing 251, 5 77.58(n)1
    74.12(a)1
      11 (54.34 cM)5
    2170691  NM_009546.21  NP_033572.21 
     889993765 
    chicken
    (Gallus gallus)
    Aves TRIM251 tripartite motif containing 25 58.87(n)
    49.84(a)
      417401  XM_415653.4  XP_415653.4 
    lizard
    (Anolis carolinensis)
    Reptilia TRIM256
    tripartite motif containing 25
    48(a)
    1 ↔ 1
    GL343198.1(658779-676108)
    zebrafish
    (Danio rerio)
    Actinopterygii BC045450.12   -- 73.88(n)   393144  BC045450.1 


    ENSEMBL Gene Tree for TRIM25 (if available)
    TreeFam Gene Tree for TRIM25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM25 gene
    ENSG000002515372  TRIM292  TRIM16L2  TRIM472  TRIM162  TRIM652  
    2 SIMAP similar genes for TRIM25 using alignment to 4 protein entries:     TRI25_HUMAN (see all proteins):
    TRIM39    TRIM26

    Find genes that share paralogs with TRIM25           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TRIM25
    PGOHUM00000237505


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM25 (see all 553)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1168106121,2
    C,F--54964857(+) AGTGAG/AGAAGA 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1156533791,2
    C,F--54964858(+) GTGAGG/AAAGAA 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1502392981,2
    --54964861(+) AGGAAG/TAAAAA 1 -- ds50010--------
    rs1389093741,2
    C--54964948(+) AAACTC/TAGGAG 1 -- ds50010--------
    rs25865211,2
    C,F,O,A,H--54964949(+) AACTCG/AGGAGG 1 -- ds500129Minor allele frequency- A:0.50NS EA NA WA CSA 2841
    rs1494813801,2
    --54965030(+) CCACCA/GCCTCT 1 -- ds50010--------
    rs1835507501,2
    --54965048(+) CACCAA/CCTGGT 1 -- ds50010--------
    rs1874800301,2
    --54965118(+) GGACAC/TAGTCC 1 -- ds50010--------
    rs1906666011,2
    --54965159(+) GCCCCA/CTGTGG 1 -- ds50010--------
    rs1459836661,2
    --54965162(+) CCATGG/TGGGGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TRIM25 (54965270 - 54991409 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TRIM25:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv32884CNV Loss17666407
    nsv524499CNV Loss19592680
    esv1004959CNV Gain20482838

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600453    OMIM disorders: --

    1 disease for TRIM25:    
    About MalaCards
    breast cancer


    Find genes that share disorders with TRIM25           About GenesLikeMe

    3 Novoseek inferred disease relationships for TRIM25 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 34 13 16144914 (3), 10781795 (2), 15781984 (2), 12943693 (1)
    breast carcinoma 17.2 7 16144914 (6), 15644556 (1)
    tumors 6.33 8 12943693 (4), 10781795 (1), 9855000 (1), 16144914 (1)

    Genetic Association Database (GAD): TRIM25
    Human Genome Epidemiology (HuGE) Navigator: TRIM25 (1 document)

    Export disorders for TRIM25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM25 gene, integrated from 10 sources (see all 90):
    (articles sorted by number of sources associating them with TRIM25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosome mapping of human (ZNF147) and mouse genes for estrogen-responsive finger protein (efp), a member of the RING finger family. (PubMed id 7789997)1, 3, 9 Inoue S....Muramatsu M. (Genomics 1995)
    2. Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein. (PubMed id 8248217)1, 2, 9 Inoue S.... Muramatsu M. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    3. Systemic distribution of estrogen-responsive finger protein (Efp) in human tissues. (PubMed id 15130519)1, 2, 9 Shimada N.... Sasano H. (Mol. Cell. Endocrinol. 2004)
    4. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    5. Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I. (PubMed id 19454348)1, 2 Gack M.U.... Garcia-Sastre A. (Cell Host Microbe 2009)
    6. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    7. Negative regulation of ISG15 E3 ligase EFP through its autoISGylation. (PubMed id 17222803)1, 2 Zou W.... Zhang D.-E. (Biochem. Biophys. Res. Commun. 2007)
    8. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I- mediated antiviral activity. (PubMed id 17392790)1, 2 Gack M.U.... Jung J.U. (Nature 2007)
    9. A ubiquitin E3 ligase Efp is up-regulated by interferons and conjugated with ISG15. (PubMed id 17069755)1, 2 Nakasato N.... Inoue S. (Biochem. Biophys. Res. Commun. 2006)
    10. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7706 HGNC: 12932 AceView: TRIM25 Ensembl:ENSG00000121060 euGenes: HUgn7706
    ECgene: TRIM25 Kegg: 7706 H-InvDB: TRIM25

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRIM25 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRIM25 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/TRIM25

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM25 gene:
    Search GeneIP for patents involving TRIM25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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