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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM24 Gene

protein-coding   GIFtS: 60
GCID: GC07P138144

Tripartite Motif Containing 24

(Previous names: transcriptional intermediary factor 1, tripartite motif-containing...)
(Previous symbol: TIF1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tripartite Motif Containing 241 2     PTC62 5
TIF11 2 3 5     TF1A2
TIF1A2 3 5     TIF1ALPHA2
Transcriptional Intermediary Factor 11 2     hTIF12
Tripartite Motif-Containing 241 2     Transcription Intermediary Factor 1-Alpha2
RNF822 3     EC 6.3.2.-3
TIF1-alpha2 3     Tripartite Motif-Containing Protein 243
E3 Ubiquitin-Protein Ligase TRIM242 3     EC 6.3.28
RING Finger Protein 822 3     

External Ids:    HGNC: 118121   Entrez Gene: 88052   Ensembl: ENSG000001227797   OMIM: 6034065   UniProtKB: O151643   

Export aliases for TRIM24 gene to outside databases

Previous GC identifers: GC07P137603 GC07P137795 GC07P132454


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRIM24 Gene:
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2
(AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The
protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated
factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively
spliced transcript variants encoding different isoforms have been described for this gene. (provided by RefSeq,
Jul 2008)

GeneCards Summary for TRIM24 Gene: 
TRIM24 (tripartite motif containing 24) is a protein-coding gene. Diseases associated with TRIM24 include cerebellar agenesis, and candidiasis, and among its related super-pathways are Signaling by FGFR1 mutants and Signaling by FGFR. GO annotations related to this gene include sequence-specific DNA binding and receptor binding. An important paralog of this gene is TRIM33.

UniProtKB/Swiss-Prot: TIF1A_HUMAN, O15164
Function: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and
modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications,
having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at
'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation
of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects
on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone
receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays
a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity)

Gene Wiki entry for TRIM24 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM24 gene promoter:
         GR   GR-alpha   Nkx2-5   CUTL1   MRF-2   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TRIM24 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM24

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32-q34   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q32-q34

TRIM24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM24 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P138144:  view genomic region     (about GC identifiers)

Start:
138,145,079 bp from pter      End:
138,274,738 bp from pter
Size:
129,660 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 137,490,163-137,615,364     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TIF1A_HUMAN, O15164 (See protein sequence)
Recommended Name: Transcription intermediary factor 1-alpha  
Size: 1050 amino acids; 116831 Da
Subunit: Interacts with CARM1, NCOA2/GRIP1, PML, KAT5/TIP60, BRD7, CBX1, CBX3 and CBX5. Part of a coactivator
complex containing TRIM24, NCOA2 and CARM1 (By similarity). Interacts with NR3C2/MCR. Interacts with the
ligand-binding domain of estrogen receptors (in vitro). Interaction with DNA-bound estrogen receptors requires
the presence of estradiol. Interacts with AR and p53/TP53. Interacts (via bromo domain) with histone H3 (via
N-terminus), provided that it is not methylated at 'Lys-4' (H3K4me0). Does not interact with histone H3 that is
methylated at 'Lys-4' (H3K4me1, H3K4me2 or H3K4me3). Interacts (via bromo domain) with histone H3 (via
N-terminus) that is acetylated at 'Lys-23' (H3K23ac). Has the highest affinity for histone H3 that is both
unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has very low affinity for histone H3 that
is methylated at 'Lys-9' (H3K9me), or acetylated at both 'Lys-9' (H3K9ac) and 'Lys-14' (H3K14ac), or acetylated
at 'Lys-27' (H3K27ac) (in vitro)
Subcellular location: Nucleus. Cytoplasm. Note=Colocalizes with sites of active transcription. Detected both in
nucleus and cytoplasm in some breast cancer samples. Predominantly nuclear
6 PDB 3D structures from and Proteopedia for TRIM24:
2YYN (3D)        3O33 (3D)        3O34 (3D)        3O35 (3D)        3O36 (3D)        3O37 (3D)    
Secondary accessions: A4D1R7 A4D1R8 O95854
Alternative splicing: 2 isoforms:  O15164-1   O15164-2   

Explore the universe of human proteins at neXtProt for TRIM24: NX_O15164

Explore proteomics data for TRIM24 at MOPED 

Post-translational modifications:

  • UniProtKB: Sumoylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15164

  • 2 DME Specific Peptides for TRIM24 (O15164)
     GSSTALLYSKRLIT  DDPNEDWCAVCQNGG 

    TRIM24 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRIM24 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_003843.3  NP_056989.2  

    ENSEMBL proteins: 
     ENSP00000340507   ENSP00000390829  
    Reactome Protein details: O15164
    Human Recombinant Protein Products for TRIM24: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TRIM24
    GenScript Custom Purified and Recombinant Proteins Services for TRIM24
    Novus Biologicals TRIM24 Proteins
    Novus Biologicals TRIM24 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005719nuclear euchromatin IEA--
    GO:0005726perichromatin fibrils IEA--
    GO:0005737cytoplasm ----

    TRIM24 for ontologies           About GeneDecksing



    TRIM24 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TRIM24
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    Novus Biologicals TRIM24 Antibodies
    Abcam antibodies for TRIM24
    Browse Antibodies at Cloud-Clone Corp. 
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    LSBio Antibodies in human, mouse, rat for TRIM24 

    Assay Products for TRIM24: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRIM24
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers
    PHF: Zinc fingers, PHD-type

    IUPHAR Guide to PHARMACOLOGY protein family classification: tripartite motif containing 24 
    TIF1 family

    5/11 InterPro protein domains (see all 11):
     IPR003649 Bbox_C
     IPR017907 Znf_RING_CS
     IPR019786 Zinc_finger_PHD-type_CS
     IPR001841 Znf_RING
     IPR001965 Znf_PHD

    Graphical View of Domain Structure for InterPro Entry O15164

    ProtoNet protein and cluster: O15164

    5 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001487 Bromodomain signature
    IPB001841 Zn-finger
    IPB001965 Zn-finger-like
    IPB003649 B-box


    UniProtKB/Swiss-Prot: TIF1A_HUMAN, O15164
    Similarity: Contains 2 B box-type zinc fingers
    Similarity: Contains 1 bromo domain
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    TRIM24 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIF1A_HUMAN, O15164
    Function: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and
    modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications,
    having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at
    'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation
    of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects
    on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone
    receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays
    a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity)
    Induction: Up-regulated in some cases of breast cancer

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI19556538
    GO:0003682chromatin binding IDA--
    GO:0003713transcription coactivator activity IDA--
    GO:0004672protein kinase activity IEA--
    GO:0004842ubiquitin-protein ligase activity IDA19556538
         
    TRIM24 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRIM24:
     Increased cell death HMECs cel  Synthetic lethal with imatinib 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Trim24):
     cellular  liver/biliary system  tumorigenesis 

    TRIM24 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Trim24tm1.1Los for TRIM24

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRIM24 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRIM24

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM24 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM24 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM24
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM24 (see all 9):
    hsa-miR-628-3p hsa-miR-551b* hsa-miR-138-2* hsa-miR-888* hsa-miR-1305 hsa-miR-511 hsa-miR-374c hsa-miR-655
    SwitchGear 3'UTR luciferase reporter plasmidTRIM24 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRIM24
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM24

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of TRIM24

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for TRIM24
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM24 (NM_003852)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM24
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                         Customized lentivirus expression plasmids for stable overexpression of TRIM24 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM24


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRIM24 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR1 mutants
    Signaling by FGFR1 mutants0.67
    Signaling by FGFR1 fusion mutants0.63
    Signaling by FGFR mutants0.67
    2Signaling by FGFR
    Signaling by FGFR in disease0.91
    3Regulation of Androgen receptor activity
    Regulation of Androgen receptor activity
    4Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TRIM24
        Regulation of Androgen receptor activity

    5        Reactome Pathways for TRIM24
        Signaling by FGFR mutants
    Signaling by FGFR1 fusion mutants
    Signaling by FGFR in disease
    Signaling by FGFR1 mutants
    Disease


    UniProtKB/Swiss-Prot: TIF1A_HUMAN, O15164
    Pathway: Protein modification; protein ubiquitination


    TRIM24 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRIM24

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/61 Interacting proteins for TRIM24 (O151643 ENSP000003405074) via UniProtKB, MINT, STRING, and/or I2D (see all 61)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS9115274
    GO:0006468protein phosphorylation ----
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0010628positive regulation of gene expression ----
    GO:0016567protein ubiquitination IDA19556538

    TRIM24 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRIM24 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM24 (TIF1A)

    5 Novoseek inferred chemical compound relationships for TRIM24 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 39.4 3 10022127 (1), 10094499 (1)
    estrogen 34.1 3 9817599 (1), 9882594 (1)
    zinc 29.2 7 9699856 (2), 12684500 (1), 10562550 (1), 9817599 (1)
    steroid 24.3 2 9774463 (1), 11518808 (1)
    estradiol 7.49 1 9774463 (1)

    Search CenterWatch for drugs/clinical trials and news about TRIM24 / TIF1A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRIM24 gene (2 alternative transcripts): 
    NM_003852.3  NM_015905.2  

    Unigene Cluster for TRIM24:

    Tripartite motif containing 24
    Hs.490287  [show with all ESTs]
    Unigene Representative Sequence: NM_015905
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343526(uc003vub.3 uc003vuc.3) ENST00000415680 ENST00000497516(uc022amn.1)
    ENST00000485318 ENST00000464210 ENST00000493595
    miRNA
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    hsa-miR-628-3p hsa-miR-551b* hsa-miR-138-2* hsa-miR-888* hsa-miR-1305 hsa-miR-511 hsa-miR-374c hsa-miR-655
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    Inhib. RNA
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    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM24

    Additional mRNA sequence: 

    AF009353.1 AF119042.1 AK075306.1 AK302679.1 AK312610.1 AL360186.1 BC028689.2 

    7 DOTS entries:

    DT.100788591  DT.414065  DT.95266726  DT.87014363  DT.100788587  DT.87009457  DT.91643354 

    24/145 AceView cDNA sequences (see all 145):

    AW513912 CD251993 AW075866 AI200685 AI457387 AW002077 AL698990 AL600797 
    AA337753 BC028689 AI133494 BG574441 BQ017468 CR600475 AA370690 AA436976 
    BM457484 BM466423 NM_015905 N89381 CR617986 AL046127 BU521570 AI017020 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM24    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b
    SP1:        -           -                                                     -                                                                           
    SP2:        -           -                                                                                                                                 
    SP3:                    -                                                     -                                                                           
    SP4:                                                                                                                                                      


    ECgene alternative splicing isoforms for TRIM24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGATGGCA
    TRIM24 Expression
    About this image


    See TRIM24 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM24

    SOURCE GeneReport for Unigene cluster: Hs.490287
        SABiosciences Expression via Pathway-Focused PCR Array including TRIM24: 
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TRIM24 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim241 , 5 tripartite motif-containing 241, 5 89.73(n)1
    94.26(a)1
      6 (17.07 cM)5
    218481  NM_145076.31  NP_659542.31 
     378708115 
    chicken
    (Gallus gallus)
    Aves TRIM241 tripartite motif containing 24 79.13(n)
    81.74(a)
      418106  XM_416340.3  XP_416340.3 
    lizard
    (Anolis carolinensis)
    Reptilia TRIM246
    Uncharacterized protein
    77(a)
    1 ↔ 1
    5(14947380-14996390)
    zebrafish
    (Danio rerio)
    Actinopterygii trim246
    tripartite motif-containing 24
    38(a)
    possible ortholog
    4(59416144-59480047)
    fruit fly
    (Drosophila melanogaster)
    Insecta bon6
    bonus
    20(a)
    1 → many
    3R(16418881-16438262)


    ENSEMBL Gene Tree for TRIM24 (if available)
    TreeFam Gene Tree for TRIM24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM24 gene
    TRIM332  TRIM662  AIRE2  TRIM282  
    1 SIMAP similar gene for TRIM24 using alignment to 1 protein entry:     TIF1A_HUMAN:
    TRIM33

    TRIM24 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2518 SNPs in TRIM24 are shown (see all 2518)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0423824
    An ovarian serous carcinoma sample4--see VAR_0423822 I T mis40--------
    VAR_0423834
    A lung squamous cell carcinoma sample4--see VAR_0423832 T N mis40--------
    VAR_0423844
    ----see VAR_0423842 S N mis40--------
    rs77993041,2
    C,F--137497177(+) tgtttT/Agtttt 2 -- int12Minor allele frequency- A:0.50WA CSA 4
    rs1428040391,2
    C--137497177(+) GTTTT-/AGTT  
     T
    /GTTTA
    GTTTT
    2 -- int10--------
    rs1501917131,2
    C--137497178(+) TTTTG-/GTTTA 
            
    TTTTG
    2 -- int10--------
    rs339574701,2
    C--137532988(+) AAAAA-/TTCACA 2 -- int10--------
    rs3689697291,2
    C--137534272(+) TGCCA-/CTCTT 
            
    TCTTT
    2 -- int10--------
    rs1898734221,2
    --137538495(+) GTGTGC/TGTGTG 2 -- int10--------
    rs731646381,2
    C--137538509(+) GTGTGC/TGTGTG 2 -- int10--------

    HapMap Linkage Disequilibrium report for TRIM24 (138145079 - 138274738 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TRIM24:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2735212CNV Deletion23290073
    esv2677536CNV Deletion23128226
    esv2292840CNV Deletion18987734
    nsv5968CNV Insertion18451855
    nsv831153CNV Loss17160897
    esv34048CNV Loss18971310

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603406   
    OMIM disorders: 188550  
    UniProtKB/Swiss-Prot: TIF1A_HUMAN, O15164
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an
    irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm
    characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered
    with a surface layer of neoplastic epithelial cells. Note=The disease is caused by mutations affecting the gene
    represented in this entry. A chromosomal aberration involving TRIM24/TIF1 is found in thyroid papillary
    carcinomas. Translocation t(7;10)(q32;q11) with RET. The translocation generates the TRIM24/RET (PTC6) oncogene

  • 17 diseases for TRIM24:    About MalaCards
    cerebellar agenesis    candidiasis    dermatomyositis    papillary thyroid carcinoma
    papillary carcinoma    thyroiditis    oral squamous cell carcinoma    acute myeloid leukemia
    renal cell carcinoma    myeloid leukemia    diabetes mellitus    squamous cell carcinoma
    neuroblastoma    leukemia    breast cancer    lung cancer
    endotheliitis


    TRIM24 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TRIM24 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 9817599 (1), 18287084 (1)

    Genetic Association Database (GAD): TRIM24
    Human Genome Epidemiology (HuGE) Navigator: TRIM24 (1 document)

    Export disorders for TRIM24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM24 gene, integrated from 9 sources (see all 83):
    (articles sorted by number of sources associating them with TRIM24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. (PubMed id 9115274)1, 2, 3, 9 Thenot S.... Cavailles V. (1997)
    2. TIF1gamma, a novel member of the transcriptional intermediary factor 1 family. (PubMed id 10022127)1, 2, 9 Venturini L....De The H. (1999)
    3. The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas. (PubMed id 10439047)1, 2, 9 Klugbauer S. and Rabes H.M. (1999)
    4. TIF1 alpha: a chromatin-specific mediator for the lig and-dependent activation function AF-2 of nuclear receptors? (PubMed id 9191165)1, 3, 9 Le Douarin B....Losson R. (1997)
    5. Trim24 targets endogenous p53 for degradation. (PubMed id 19556538)1, 2, 9 Allton K....Barton M.C. (2009)
    6. TRIM24 mediates ligand-dependent activation of androg en receptor and is repressed by a bromodomain-containing protein, BRD7, in pros tate cancer cells. (PubMed id 19909775)1, 2, 9 Kikuchi M....Hatakeyama S. (2009)
    7. TRIM24 links a non-canonical histone signature to breast cancer. (PubMed id 21164480)1, 2 Tsai W.W.... Barton M.C. (2010)
    8. Genome-wide association studies in an isolated founde r population from the Pacific Island of Kosrae. (PubMed id 19197348)1, 4 Lowe J.K....Friedman J.M. (2009)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    10. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8805 HGNC: 11812 AceView: TIF1 Ensembl:ENSG00000122779 euGenes: HUgn8805
    ECgene: TRIM24 H-InvDB: TRIM24

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM24 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRIM24 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRIM24 gene:
    Search GeneIP for patents involving TRIM24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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