Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM24 Gene

protein-coding   GIFtS: 56
GCID: GC07P138144

tripartite motif containing 24

(Previous names: transcriptional intermediary factor 1, tripartite motif-containing...)
(Previous symbol: TIF1)
 Explore 17 diseases affiliated with
TRIM24 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRIM24    

Aliases
for TRIM24 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tripartite Motif Containing 241 2     RING Finger Protein 822 3
TIF11 2 3 5     PTC62 5
TIF1A1 2 3 5     Tif1a1
RNF821 2 3     TF1A2
HTIF11     TIF1ALPHA2
Transcriptional Intermediary Factor 11 2     Transcription Intermediary Factor 1-Alpha2
Tripartite Motif-Containing 241 2     EC 6.3.2.-3
TIF1-Alpha1     Tripartite Motif-Containing Protein 243
E3 Ubiquitin-Protein Ligase TRIM242 3     EC 6.3.28

External Ids:    HGNC: 118121   Entrez Gene: 88052   Ensembl: ENSG000001227797   OMIM: 6034065   UniProtKB: O151643   

Export aliases for TRIM24 gene to outside databases

Previous GC identifers: GC07P137603 GC07P137795 GC07P132454


Summaries
for TRIM24 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TRIM24:
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2)
region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein
localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The
protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a
RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants
encoding different isoforms have been described for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TIF1A_HUMAN, O15164
Function: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the
transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest
affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3
protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in
the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates
ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates
transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic
acid-dependent proliferation of hepatocytes (By similarity)

Gene Wiki entry for TRIM24


Genomic Views
for TRIM24 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM24 gene promoter:
         GR   GR-alpha   Nkx2-5   CUTL1   MRF-2   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TRIM24 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM24

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32-q34   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q32-q34

TRIM24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM24 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P138144:  view genomic region     (about GC identifiers)

Start:
 138,144,953 bp from pter      End:
 138,274,738 bp from pter
Size:
 129,786 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 137,490,163-137,615,364     

Proteins
for TRIM24 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TIF1A_HUMAN, O15164 (See protein sequence)
Recommended Name: Transcription intermediary factor 1-alpha  
Size: 1050 amino acids; 116831 Da
Subunit: Interacts with CARM1, NCOA2/GRIP1, PML, KAT5/TIP60, BRD7, CBX1, CBX3 and CBX5. Part of a coactivator complex
containing TRIM24, NCOA2 and CARM1 (By similarity). Interacts with NR3C2/MCR. Interacts with the ligand-binding domain
of estrogen receptors (in vitro). Interaction with DNA-bound estrogen receptors requires the presence of estradiol.
Interacts with AR and p53/TP53. Interacts (via bromo domain) with histone H3 (via N-terminus), provided that it is not
methylated at 'Lys-4' (H3K4me0). Does not interact with histone H3 that is methylated at 'Lys-4' (H3K4me1, H3K4me2 or
H3K4me3). Interacts (via bromo domain) with histone H3 (via N-terminus) that is acetylated at 'Lys-23' (H3K23ac). Has
the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac).
Has very low affinity for histone H3 that is methylated at 'Lys-9' (H3K9me), or acetylated at both 'Lys-9' (H3K9ac)
and 'Lys-14' (H3K14ac), or acetylated at 'Lys-27' (H3K27ac) (in vitro)
Subcellular location: Nucleus. Cytoplasm. Note=Colocalizes with sites of active transcription. Detected both in nucleus
and cytoplasm in some breast cancer samples. Predominantly nuclear
6 PDB 3D structures from and Proteopedia for TRIM24:
2YYN (3D)        3O33 (3D)        3O34 (3D)        3O35 (3D)        3O36 (3D)        3O37 (3D)    
Secondary accessions: A4D1R7 A4D1R8 O95854
Alternative splicing: 2 isoforms:  O15164-1   O15164-2   

Explore the universe of human proteins at neXtProt for TRIM24: NX_O15164

Post-translational modifications:

  • Sumoylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15164

    • 2 DME Specific Peptides for TRIM24 (O15164)
     GSSTALLYSKRLIT  DDPNEDWCAVCQNGG 

    TRIM24 Protein expression data from MOPED and PaxDb:    About this image 
    TRIM24 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_003843.3  NP_056989.2  

    ENSEMBL proteins: 
     ENSP00000403347   ENSP00000340507   ENSP00000402079   ENSP00000390829  
    Reactome Protein details: O15164
    Human Recombinant Protein Products for TRIM24: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for TRIM24 
    GenScript Custom Purified and Recombinant Proteins Services for TRIM24
    Novus Biologicals TRIM24 Proteins
    Novus Biologicals TRIM24 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005719nuclear euchromatin IEA--
    GO:0005726perichromatin fibrils IEA--
    GO:0005737cytoplasm ----

    TRIM24 for ontologies           About GeneDecksing



    TRIM24 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TRIM24
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TRIM24 
    GenScript Custom Superior Antibodies Services for TRIM24
    Novus Biologicals TRIM24 Antibodies
    Abcam antibodies for TRIM24 
    Browse Antibodies at Uscn
    Search ThermoFisher Antibodies for TRIM24

    Assay Products for TRIM24: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRIM24
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for TRIM24 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRIM24 for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR003649 Bbox_C
     IPR017907 Znf_RING_CS
     IPR019786 Zinc_finger_PHD-type_CS
     IPR001841 Znf_RING
     IPR001965 Znf_PHD

    Graphical View of Domain Structure for InterPro Entry O15164

    ProtoNet protein and cluster: O15164

    5 Blocks protein families:
    IPB000315 B-box zinc finger signature
    IPB001487 Bromodomain signature
    IPB001841 Zn-finger
    IPB001965 Zn-finger-like
    IPB003649 B-box


    UniProtKB/Swiss-Prot: TIF1A_HUMAN, O15164
    Similarity: Contains 2 B box-type zinc fingers
    Similarity: Contains 1 bromo domain
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    Function
    for TRIM24 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIF1A_HUMAN, O15164
    Function: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the
    transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest
    affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3
    protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in
    the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates
    ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates
    transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic
    acid-dependent proliferation of hepatocytes (By similarity)
    Induction: Up-regulated in some cases of breast cancer

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI19556538
    GO:0003682chromatin binding IDA--
    GO:0003713transcription coactivator activity IDA--
    GO:0004672protein kinase activity IEA--
    GO:0004842ubiquitin-protein ligase activity IDA19556538
         
    TRIM24 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRIM24:
     Increased cell death HMECs cel  Synthetic lethal with imatinib 

         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Trim24):
     cellular  liver/biliary system  tumorigenesis 

    TRIM24 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Trim24tm1.1Los for TRIM24
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TRIM24 

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): TRIM24
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM24
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM24 (see all 9):
    hsa-miR-628-3p hsa-miR-551b* hsa-miR-138-2* hsa-miR-888* hsa-miR-1305 hsa-miR-511 hsa-miR-374c hsa-miR-655
    SwitchGear 3'UTR luciferase reporter plasmid: TRIM24 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM24 (see all 7)
    OriGene shRNA RFP: TRIM24
    OriGene siRNA: TRIM24
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM24
    Sirion Biotech Custom design and validation of potent shRNA sequences against TRIM24 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TRIM24
    Sirion Biotech Customized adenovirus for overexpression of TRIM24 
    Sirion Biotech Customized adenovirus for potent knockdown of TRIM24

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM24 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM24 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM24 (NM_003852)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM24 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TRIM24
    Search LifeMap BioReagents cell lines for TRIM24
    Sirion Biotech Customized stable knockdown cell line services for TRIM24 
    Sirion Biotech Customized inducible knockdown cell line services for TRIM24
    Sirion Biotech Customized stable overexpressing cell line services for TRIM24
    Sirion Biotech Customized inducible overexpressing cell line services for TRIM24

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM24


    Pathways & Interactions
    for TRIM24 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR1 mutants
    		Signaling by FGFR1 mutants1.00
    		Signaling by FGFR1 fusion mutants0.63
    		Signaling by FGFR mutants0.67
    		FGFR1 fusion proteins recruit PIK3R10.37
    2Disease
    		Disease1.00
    3Regulation of Androgen receptor activity
    		Regulation of Androgen receptor activity1.00
    4Signaling by FGFR
    		Signaling by FGFR in disease0.91

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for TRIM24 
        Regulation of Androgen receptor activity

    5/6        Reactome Pathways for TRIM24 (see all 6)
        Signaling by FGFR mutants
    Signaling by FGFR1 fusion mutants
    Signaling by FGFR in disease
    Signaling by FGFR1 mutants
    Disease


    UniProtKB/Swiss-Prot: TIF1A_HUMAN, O15164
    Pathway: Protein modification; protein ubiquitination


    TRIM24 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRIM24

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for TRIM24 (O151643 ENSP000003405074) via UniProtKB, MINT, STRING, and/or I2D (see all 47)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ESR2Q927313, ENSP000003439254I2D: score=3 STRING: ENSP00000343925
    RARAP102763, ENSP000002540664I2D: score=3 STRING: ENSP00000254066
    ARP102753, ENSP000003638224I2D: score=2 STRING: ENSP00000363822
    NR3C1P041503, ENSP000002315094I2D: score=2 STRING: ENSP00000231509
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS9115274
    GO:0006468protein phosphorylation ----
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0010628positive regulation of gene expression ----
    GO:0016567protein ubiquitination IDA19556538

    TRIM24 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRIM24 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRIM24 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM24
    5 Novoseek chemical compound relationships for TRIM24 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 39.4 3 10022127 (1), 10094499 (1)
    estrogen 34.1 3 9817599 (1), 9882594 (1)
    zinc 29.2 7 9699856 (2), 12684500 (1), 10562550 (1), 9817599 (1)
    steroid 24.3 2 9774463 (1), 11518808 (1)
    estradiol 7.49 1 9774463 (1)

    Search CenterWatch for drugs/clinical trials and news about TRIM24 / TIF1A 

    Transcripts
    for TRIM24 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRIM24 gene (2 alternative transcripts): 
    NM_003852.3  NM_015905.2  

    Unigene Cluster for TRIM24:

    Tripartite motif containing 24
    Hs.490287  [show with all ESTs]
    Unigene Representative Sequence: NM_015905
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000439939 ENST00000343526(uc003vub.3 uc003vuc.3) ENST00000452999
    ENST00000415680 ENST00000476785 ENST00000497516(uc022amn.1) ENST00000494040
    ENST00000464210 ENST00000485318 ENST00000493595

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): TRIM24
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM24
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM24 (see all 9):
    hsa-miR-628-3p hsa-miR-551b* hsa-miR-138-2* hsa-miR-888* hsa-miR-1305 hsa-miR-511 hsa-miR-374c hsa-miR-655
    SwitchGear 3'UTR luciferase reporter plasmid: TRIM24 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM24 (see all 7)
    OriGene shRNA RFP: TRIM24
    OriGene siRNA: TRIM24
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM24
    Sirion Biotech Custom design and validation of potent shRNA sequences against TRIM24 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM24 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM24 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM24 (NM_003852)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM24 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM24
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIM24
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM24
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM24

    Additional cDNA sequence: 

    AF009353.1 AF119042.1 AK075306.1 AK302679.1 AK312610.1 AL360186.1 BC028689.2 

    7 DOTS entries:

    DT.100788591  DT.414065  DT.95266726  DT.87014363  DT.100788587  DT.87009457  DT.91643354 

    24/145 AceView cDNA sequences (see all 145):

    AI932874 AA337753 AI457387 AI200685 AW002077 AW075866 BQ017468 BG574441 
    CR600475 AI133494 AI017020 AA370690 AA844662 BX364951 AA436976 AL698990 
    BC028689 CB153120 AW513912 CD251993 AK075306 AL600797 AL046127 N89381 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM24    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b
    SP1:        -           -                                                     -                                                                           
    SP2:        -           -                                                                                                                                 
    SP3:                    -                                                     -                                                                           
    SP4:                                                                                                                                                      


    ECgene alternative splicing isoforms for TRIM24

    Expression
    for TRIM24 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAGATGGCA
    TRIM24 Expression
    About this image
    See TRIM24 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM24

    SOURCE GeneReport for Unigene cluster: Hs.490287
        SABiosciences Expression via Pathway-Focused PCR Array including TRIM24: 

              Ubiquitin Ligases in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM24
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIM24
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM24
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM24
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM24

    Orthologs
    for TRIM24 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TRIM24 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TRIM241 tripartite motif containing 24 79.13(n)
    81.74(a)    		   418106  XM_416340.3  XP_416340.3 
    lizard
    (Anolis carolinensis)    		 Reptilia TRIM246
    		 --
    		 78(a)
    		 1 ↔ 1
    		 5(14965457-14996390)
    zebrafish
    (Danio rerio)    		 Actinopterygii trim246
    trim33l6
    		 tripartite motif-containing 33-like
    		 38(a)
    11(a)
    		 1 ↔ 1
    possible ortholog
    		 4(59416144-59480047)
    16(30992261-31018660)
    fruit fly
    (Drosophila melanogaster)    		 Insecta bon6
    		 bonus
    		 19(a)
    		 1 → many
    		 3R(16418881-16438262)


    ENSEMBL Gene Tree for TRIM24 (if available)
    TreeFam Gene Tree for TRIM24 (if available) 

    Paralogs
    for TRIM24 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM24 gene
    TRIM332  TRIM662  TRIM282  
    1 SIMAP similar gene for TRIM24 using alignment to 3 protein entries:     TIF1A_HUMAN (see all proteins):
    TRIM33

    TRIM24 for paralogs           About GeneDecksing



    Genomic Variants
    for TRIM24 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2120 NCBI SNPs in TRIM24 are shown (see all 2120)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs731646241,2
    		--137488225(+) TCCTTC/GCCTAC 2 -- us2k10--------
    rs119837541,2
    		C,F,H--137488497(+) GCGTGT/CACAAA 2 -- us2k11Minor allele frequency- C:0.03NA 120
    rs784752911,2
    		--137489070(+) AAAAAA/GGTAAA 2 -- us2k10--------
    rs1116670721,2
    		--137489630(+) CCTCCT/GACCAT 2 -- us2k12Minor allele frequency- G:0.33CSA 3
    rs77998181,2
    		C,F,A,H--137490237(+) CCCGGT/CTTGCT 2 -- ut5118Minor allele frequency- C:0.41NS EA NA CSA WA 2215
    rs1126192231,2
    		C--137490862(+) AGGGGC/TGAGCA 2 -- int13Minor allele frequency- T:0.28WA NA 240
    rs783663601,2
    		C--137491096(+) TAACTG/CCTACC 2 -- int11Minor allele frequency- C:0.01EA 120
    rs799185511,2
    		--137492010(+) GGAGCC/GAAAGG 2 -- int10--------
    rs1118564901,2
    		--137492709(+) TATTTT/ATTTTT 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs132463621,2
    		C,F--137492775(+) ctcacT/Cgcaac 2 -- int13Minor allele frequency- C:0.33NA 6

    HapMap Linkage Disequilibrium report for TRIM24 (138144953 - 138274738 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TRIM24
         1 CNV: 47950

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM24
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM24

    Disorders / Diseases
    for TRIM24 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRIM24 for disorders           About GeneDecksing

    OMIM gene information: 603406   
    OMIM disorders: 188550  
    UniProtKB/Swiss-Prot: TIF1A_HUMAN, O15164
  • Defects in TRIM24 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the
    • thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary
    carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of
    fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration
    involving TRIM24/TIF1 is found in thyroid papillary carcinomas. Translocation t(7;10)(q32;q11) with RET. The
    translocation generates the TRIM24/RET (PTC6) oncogene

    17 diseases for TRIM24:    About MalaCards
    cerebellar agenesis    oral squamous cell carcinoma    arterial calcification    squamous cell carcinoma
    papillary thyroid carcinoma    acute myeloid leukemia    thyroid carcinoma    myeloid leukemia
    renal cell carcinoma    diabetes mellitus    candidiasis    dermatomyositis
    thyroiditis    carcinoma    leukemia    breast cancer
    neuroblastoma

    1 Novoseek disease relationship for TRIM24 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 9817599 (1), 18287084 (1)

    Human Genome Epidemiology (HuGE) Navigator: TRIM24 (1 document)

    Export disorders for TRIM24 gene to outside databases

    Publications
    for TRIM24 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM24 gene, integrated from 9 sources (see all 80):
    (articles sorted by number of sources associating them with TRIM24)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. (PubMed id 9115274)1, 2, 3, 9 Thenot S.... Cavailles V. (1997)
    2. TIF1gamma, a novel member of the transcriptional intermediary factor 1 family. (PubMed id 10022127)1, 2, 9 Venturini L....De The H. (1999)
    3. The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas. (PubMed id 10439047)1, 2, 9 Klugbauer S. and Rabes H.M. (1999)
    4. TIF1 alpha: a chromatin-specific mediator for the lig and-dependent activation function AF-2 of nuclear receptors? (PubMed id 9191165)1, 3, 9 Le Douarin B....Losson R. (1997)
    5. Trim24 targets endogenous p53 for degradation. (PubMed id 19556538)1, 2, 9 Allton K....Barton M.C. (2009)
    6. TRIM24 mediates ligand-dependent activation of androg en receptor and is repressed by a bromodomain-containing protein, BRD7, in pros tate cancer cells. (PubMed id 19909775)1, 2, 9 Kikuchi M....Hatakeyama S. (2009)
    7. TRIM24 links a non-canonical histone signature to breast cancer. (PubMed id 21164480)1, 2 Tsai W.W.... Barton M.C. (2010)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    10. Crucial role of the H11-H12 loop in stabilizing the active conformation of the human mineralocorticoid receptor. (PubMed id 10935545)1, 2 Hellal-Levy C....Rafestin-Oblin M.-E. (2000)

    External Searches for TRIM24 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TRIM24 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8805 HGNC: 11812 AceView: TIF1 Ensembl:ENSG00000122779 euGenes: HUgn8805
    ECgene: TRIM24 H-InvDB: TRIM24

    Other Databases showing TRIM24 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TRIM24 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM24 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRIM24 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TRIM24 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TRIM24 gene:
    Search GeneIP for patents involving TRIM24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TRIM24 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of TRIM24
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for TRIM24  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM24   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM24  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TRIM24   OriGene 3'-UTR Clone for TRIM24  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM24   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM24  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRIM24   OriGene Custom Protein Services for TRIM24  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIM24
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM24
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM24
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM24
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM24
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM24
     GenScript Custom Purified and Recombinant Proteins Services for TRIM24 GenScript cDNA clones with any tag delivered in your preferred vector for TRIM24
     GenScript Custom Assay Services for TRIM24 GenScript Custom Superior Antibodies Services for TRIM24
     GenScript Custom overexpressing Cell Line Services for TRIM24 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TRIM24 promoter
     Search Chromatin IP Primers for TRIM24
     RT2 qPCR Primer Assay in human, mouse, rat TRIM24
     GNC Network for TRIM24
     SABiosciences PCR Arrays including human, mouse, rat TRIM24
     Search Tocris compounds for TRIM24
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TRIM24 antibodies
     TRIM24 proteins
     TRIM24 lysates
     Antibodies for TRIM24
     See all of Abcam's Antibodies, Kits and Proteins for TRIM24
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for TRIM24
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM24
     SwitchGear 3'UTR luciferase reporter plasmids for TRIM24
     SwitchGear Promoter luciferase reporter plasmids for TRIM24
     Search ThermoFisher Antibodies for TRIM24
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM24
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TRIM24
    Sirion Biotech Customized:
     stable knockdown cell line services for TRIM24
     inducible knockdown cell line services for TRIM24
     design and validation of potent shRNA sequences against TRIM24
     adenovirus for potent knockdown of TRIM24
     adenovirus for overexpression of TRIM24
     stable overexpressing cell line services for TRIM24
     inducible overexpressing cell line services for TRIM24
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      TRIM24 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4