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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM23 Gene

protein-coding   GIFtS: 50
GCID: GC05M064885

tripartite motif containing 23

(Previous names: ADP-ribosylation factor domain protein 1, 64kDa, tripartite...)
(Previous symbol: ARFD1)
 Explore 4 diseases affiliated with
TRIM23 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRIM23    

Aliases
for TRIM23 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tripartite Motif Containing 231 2     ADP-Ribosylation Factor Domain-Containing Protein 12 3
ARD11 2 3     GTP-Binding Protein ARD-12 3
ARFD11 2 3     RING Finger Protein 462 3
RNF461 2 3     ARF Domain Protein 12
ADP-Ribosylation Factor Domain Protein 1, 64kDa1 2     E3 Ubiquitin-Protein Ligase TRIM232
Tripartite Motif-Containing 231 2     Tripartite Motif Protein TRIM232
Tripartite Motif-Containing Protein 232 3     EC 6.3.2.-3

External Ids:    HGNC: 6601   Entrez Gene: 3732   Ensembl: ENSG000001135957   OMIM: 6017475   UniProtKB: P364063   

Export aliases for TRIM23 gene to outside databases

Previous GC identifers: GC05M064902 GC05M064921 GC05M061841


Summaries
for TRIM23 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TRIM23:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a
member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus
contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a
GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes
and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one
compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene
have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TRI23_HUMAN, P36406
Function: Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144,
participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of
NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin
catalytic subunit

Gene Wiki entry for TRIM23


Genomic Views
for TRIM23 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM23 gene promoter:
         AhR   GATA-3   CUTL1   RelA   NF-kappaB   Arnt   GATA-2   GATA-1   Pax-4a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRIM23 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM23

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.3   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q12.3

TRIM23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM23 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M064885:  view genomic region     (about GC identifiers)

Start:
 64,885,507 bp from pter      End:
 64,921,802 bp from pter
Size:
 36,296 bases      Orientation:
 minus strand

Proteins
for TRIM23 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TRI23_HUMAN, P36406 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM23  
Size: 574 amino acids; 64067 Da
Subunit: Interacts with PSCD1. Interacts with human cytomegalovirus protein UL144; this interaction might causes
auto-ubiquitination of TRAF6, leading to NF-kappaB activation
Subcellular location: Endomembrane system. Golgi apparatus membrane. Lysosome membrane. Note=Membrane-associated with
the Golgi complex and lysosomal structures
Secondary accessions: Q9BZY4 Q9BZY5
Alternative splicing: 3 isoforms:  P36406-1   P36406-2   P36406-3   

Explore the universe of human proteins at neXtProt for TRIM23: NX_P36406

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P36406

    • TRIM23 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001647.1  NP_150230.1  NP_150231.1  

    ENSEMBL proteins: 
     ENSP00000231524   ENSP00000370406   ENSP00000274327   ENSP00000427103   ENSP00000424044  
     ENSP00000422144  

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    Novus Biologicals TRIM23 Proteins
    Novus Biologicals TRIM23 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TRIM23

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IDA9671726
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005765lysosomal membrane IDA9671726


    TRIM23 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TRIM23

    Protein Domains /
    Families
    for TRIM23 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRIM23 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR003649 Bbox_C
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR006689 Small_GTPase_ARF/SAR
     IPR000315 Znf_B-box

    Graphical View of Domain Structure for InterPro Entry P36406

    ProtoNet protein and cluster: P36406

    4 Blocks protein families:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003649 B-box
    IPB006688 ADP-ribosylation factor


    UniProtKB/Swiss-Prot: TRI23_HUMAN, P36406
    Domain: The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity
    Similarity: In the C-terminal section; belongs to the small GTPase superfamily. Arf family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    Function
    for TRIM23 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TRI23_HUMAN, P36406
    Function: Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144,
    participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of
    NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin
    catalytic subunit

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM23
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM23 (see all 26):
    hsa-miR-30c hsa-miR-137 hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-200a hsa-miR-128 hsa-miR-30d hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmid: TRIM23 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM23 (see all 4)
    OriGene shRNA RFP: TRIM23
    OriGene siRNA: TRIM23
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM23

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM23 (see all 5)
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA8700863
    GO:0004842ubiquitin-protein ligase activity IDA15684077
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IDA8700863
    GO:0008047enzyme activator activity TAS8473324


    TRIM23 for ontologies           About GeneDecksing



    Pathways & Interactions
    for TRIM23 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: TRI23_HUMAN, P36406
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM23

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/64 Interacting proteins for TRIM23 (P364061, 2, 3 ENSP000002315244) via UniProtKB, MINT, STRING, and/or I2D (see all 64)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    GEMP550401, 2, 3, ENSP000002975964EBI-740098,EBI-744104 MINT-66445 I2D: score=5 STRING: ENSP00000297596
    FLAD1Q8NFF52, 3, ENSP000002921804MINT-66299 I2D: score=5 STRING: ENSP00000292180
    LNX1Q8TBB12, 3, ENSP000002639254MINT-67458 I2D: score=5 STRING: ENSP00000263925
    TRIM23P364061, 2EBI-740098,EBI-740098 MINT-66134
    GGA2Q9UJY42, 3, ENSP000003119624MINT-66850 I2D: score=5 STRING: ENSP00000311962
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS8473324
    GO:0006471protein ADP-ribosylation ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0016567protein ubiquitination IDA15684077
    GO:0019048virus-host interaction IEA--


    TRIM23 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRIM23 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRIM23 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM23
    3 Novoseek chemical compound relationships for TRIM23 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 42.5 4 9020091 (3), 16413270 (1)
    adp 37.4 4 9671726 (2)
    atp 17.8 2 15684077 (1), 16413270 (1)

    Search CenterWatch for drugs/clinical trials and news about TRIM23 / TRI23 

    Transcripts
    for TRIM23 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRIM23 gene (3 alternative transcripts): 
    NM_001656.3  NM_033227.2  NM_033228.2  

    Unigene Cluster for TRIM23:

    Tripartite motif containing 23
    Hs.792  [show with all ESTs]
    Unigene Representative Sequence: NM_001656
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000231524(uc003jtw.3 uc003jtx.3 uc003jty.3) ENST00000381018
    ENST00000274327 ENST00000508808 ENST00000506400 ENST00000505205 ENST00000513794


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM23
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM23 (see all 26):
    hsa-miR-30c hsa-miR-137 hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-200a hsa-miR-128 hsa-miR-30d hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmid: TRIM23 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM23 (see all 4)
    OriGene shRNA RFP: TRIM23
    OriGene siRNA: TRIM23
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM23
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM23
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM23

    Additional cDNA sequence: 

    AF230397.1 AF230398.1 AF230399.1 AK292814.1 BC022510.1 L04510.1 

    9 DOTS entries:

    DT.446269  DT.100754324  DT.100021171  DT.100021172  DT.100754323  DT.100693545  DT.120812687  DT.91691406 
    DT.102824239 

    24/96 AceView cDNA sequences (see all 96):

    BC022510 AL527955 BM677710 NM_033227 NM_001656 BM547031 L04510 F09406 
    BX107879 BM725267 AF230397 AI021991 F11746 NM_033228 H78121 AA689423 
    T08980 AU137144 BG026654 BQ720704 BF109155 BF793012 T08981 H92443 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM23    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14
    SP1:                                            -                                   -     -               
    SP2:                                            -                                         -               
    SP3:                                            -                                                         
    SP4:                          -                                                                           
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for TRIM23

    Expression
    for TRIM23 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAAGGCCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TRIM23 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM23

    SOURCE GeneReport for Unigene cluster: Hs.792
        SABiosciences Expression via Pathway-Focused PCR Array including TRIM23: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for TRIM23 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TRIM23 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TRIM231 tripartite motif containing 23 82.93(n)
    94.08(a)    		   427164  XM_424752.3  XP_424752.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TRIM236
    		 --
    		 92(a)
    		 1 ↔ 1
    		 2(10704893-10726538)
    zebrafish
    (Danio rerio)    		 Actinopterygii trim231 tripartite motif containing 23 76.68(n)
    92.23(a)    		   767706  NM_001076644.1  NP_001070112.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 50(a)
    		 1 ↔ 1
    		 GroupUn.3950(27259-29534)
    worm
    (Caenorhabditis elegans)    		 Secernentea arc-11 Protein ARC-1 49.15(n)
    38.28(a)    		   174525  NM_063688.4  NP_496089.3 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATARFB1A6
    ATARFD1B6
    (see all 3)    		 ADP-ribosylation factor D1B
    (see all 3)    		 44(a)
    38(a)
    (see all 3)    		 possible ortholog
    many ↔ many
    (see all 3)    		 2(6653791-6655501)
    1(495050-496062)


    ENSEMBL Gene Tree for TRIM23 (if available)
    TreeFam Gene Tree for TRIM23 (if available) 

    Paralogs
    for TRIM23 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM23 gene
    ARL4A2  ARL112  ARF42  ARF52  ARF12  ARL4D2  ARF32  ARL142  
    ARF62  ARL92  ARL17B2  ARL4C2  ARL102  
    18/19 SIMAP similar genes for TRIM23 using alignment to 4 protein entries:     TRI23_HUMAN (see all proteins) (see all similar genes):
    ARF1    ARF3    ARF6    ARL14    ARL2    ARL5B
    ARL4D    ARL11    ARL6    ARL4C    ARL4A    ARL8A
    ARL8B    RANP1    ARFRP1    ARL15    SAR1A    TRIM3

    TRIM23 for paralogs           About GeneDecksing



    Genomic Variants
    for TRIM23 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/640 NCBI SNPs in TRIM23 are shown (see all 640)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs606626761,2
    		F,--64885086(+) ATACTA/GTGTTT 3 -- ds50011Minor allele frequency- G:0.14WA 118
    rs432141,2
    		C,F,O,A,H,--64885295(+) ATGTGG/ACCTAT 3 -- ds500127Minor allele frequency- A:0.27NS EA NA WA 2890
    rs1903921181,2
    		--64885612(+) ACTACA/GGCTAT 3 -- ut310--------
    rs1826051941,2
    		--64885798(+) AATAGC/GAGCTT 3 -- ut310--------
    rs1875833521,2
    		--64885874(+) AGGCAA/CAATTT 3 -- ut310--------
    rs1914353731,2
    		--64885884(+) TTTCAA/GCTGTG 3 -- ut310--------
    rs2464001,2
    		C,F,H,--64885885(-) ACACAA/GTTGAA 3 -- ut31 ese319Minor allele frequency- G:0.50MN EA NS NA WA CSA 2436
    rs133613921,2
    		C,F,H,--64885979(+) TTCTTC/AAATTA 3 -- ut31 trp39Minor allele frequency- A:0.01NS EA NA WA 1194
    rs1421179581,2
    		C,--64886045(+) AGTTAC/TTGAAA 3 -- ut310--------
    rs756325241,2
    		F,--64886214(+) TTGTTT/CTCTAA 3 -- ut31 int11Minor allele frequency- C:0.02NA 120

    HapMap Linkage Disequilibrium report for TRIM23 (64885507 - 64921802 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TRIM23: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM23
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM23

    Disorders / Diseases
    for TRIM23 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRIM23 for disorders           About GeneDecksing

    OMIM gene information: 601747    OMIM disorders: --

    4 diseases for TRIM23:    About MalaCards
    macular degeneration    cholera    ataxia    malaria

    1 Novoseek disease relationship for TRIM23 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholera 62.4 1 16413270 (1)


    Export disorders for TRIM23 gene to outside databases

    Publications
    for TRIM23 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM23 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with TRIM23)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl- terminal ADP-ribosylation factor domain. (PubMed id 8473324)1, 2, 3 Mishima K.... Vaughan M. (1993)
    2. Localization of ADP-ribosylation factor domain protein 1 (ARD1) in lysosomes and Golgi apparatus. (PubMed id 9671726)1, 2, 9 Vitale N.... Vaughan M. (1998)
    3. E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1). (PubMed id 15684077)1, 2, 9 Vichi A....Vaughan M. (2005)
    4. Specific functional interaction of human cytohesin-1 and ADP- ribosylation factor domain protein (ARD1). (PubMed id 10748148)1, 2, 9 Vitale N.... Vaughan M. (2000)
    5. Identification of TRIM23 as a cofactor involved in the regulation of NF-kappaB by human cytomegalovirus. (PubMed id 19176615)1, 2 Poole E....Sinclair J. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2 Reymond A.... Ballabio A. (2001)
    8. Identification of lysosomal and Golgi localization signals in GAP and ARF domains of ARF domain protein 1. (PubMed id 10982851)1, 9 Vitale N....Vaughan M. (2000)
    9. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    External Searches for TRIM23 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing TRIM23 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 373 HGNC: 660 AceView: TRIM23 Ensembl:ENSG00000113595 euGenes: HUgn373
    ECgene: TRIM23 H-InvDB: TRIM23

    Other Databases showing TRIM23 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TRIM23 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM23 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TRIM23 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TRIM23 gene:
    Search GeneIP for patents involving TRIM23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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