Aliases for TRIM23 Gene
External Ids for TRIM23 Gene
Previous HGNC Symbols for TRIM23 Gene
Previous GeneCards Identifiers for TRIM23 Gene
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRIM23 Gene
TRIM23 (Tripartite Motif Containing 23) is a Protein Coding gene. Diseases associated with TRIM23 include cholera. GO annotations related to this gene include identical protein binding and ubiquitin-protein transferase activity. An important paralog of this gene is ENSG00000272822.
UniProtKB/Swiss-Prot for TRIM23 Gene
Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in Lys-63-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.