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TRIM23 Gene

protein-coding   GIFtS: 53
GCID: GC05M064885

Tripartite Motif Containing 23

(Previous names: ADP-ribosylation factor domain protein 1, 64kDa, tripartite...)
(Previous symbol: ARFD1)
  See TRIM23-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 231 2     ADP-Ribosylation Factor Domain-Containing Protein 12 3
ARFD11 2 3     GTP-Binding Protein ARD-12 3
ADP-Ribosylation Factor Domain Protein 1, 64kDa1 2     RING Finger Protein 462 3
Tripartite Motif-Containing 231 2     ARF Domain Protein 12
Tripartite Motif-Containing Protein 232 3     E3 Ubiquitin-Protein Ligase TRIM232
ARD12 3     Tripartite Motif Protein TRIM232
RNF462 3     EC 6.3.2.-3

External Ids:    HGNC: 6601   Entrez Gene: 3732   Ensembl: ENSG000001135957   OMIM: 6017475   UniProtKB: P364063   

Export aliases for TRIM23 gene to outside databases

Previous GC identifers: GC05M064902 GC05M064921 GC05M061841


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIM23 Gene:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a
member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy
terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino
terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The
protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular
transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three
alternatively spliced transcript variants for this gene have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRIM23 Gene:
TRIM23 (tripartite motif containing 23) is a protein-coding gene. Diseases associated with TRIM23 include cholera. GO annotations related to this gene include ubiquitin-protein ligase activity and identical protein binding. An important paralog of this gene is ARL2.

UniProtKB/Swiss-Prot: TRI23_HUMAN, P36406
Function: Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein
UL144, participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled
activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the
cholera toxin catalytic subunit

Gene Wiki entry for TRIM23 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM23 gene promoter:
         AhR   GATA-3   CUTL1   RelA   NF-kappaB   Arnt   GATA-2   GATA-1   Pax-4a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM23 promoter sequence
   Search Chromatin IP Primers for TRIM23

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.3   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q12.3

TRIM23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM23 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M064885:  view genomic region     (about GC identifiers)

Start:
64,885,507 bp from pter      End:
64,921,802 bp from pter
Size:
36,296 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRI23_HUMAN, P36406 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM23  
Size: 574 amino acids; 64067 Da
Subunit: Interacts with PSCD1. Interacts with human cytomegalovirus protein UL144; this interaction might causes
auto-ubiquitination of TRAF6, leading to NF-kappaB activation
Secondary accessions: Q9BZY4 Q9BZY5
Alternative splicing: 3 isoforms:  P36406-1   P36406-2   P36406-3   

Explore the universe of human proteins at neXtProt for TRIM23: NX_P36406

Explore proteomics data for TRIM23 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys8
  • Modification sites at PhosphoSitePlus

  • See TRIM23 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001647.1  NP_150230.1  NP_150231.1  

    ENSEMBL proteins: 
     ENSP00000231524   ENSP00000370406   ENSP00000274327   ENSP00000427103   ENSP00000424044  
     ENSP00000422144  

    TRIM23 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Custom MassSpec
    OriGene Custom Protein Services for TRIM23
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    Novus Biologicals TRIM23 Proteins
    Novus Biologicals TRIM23 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TRIM23 

    TRIM23 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals TRIM23 Antibodies
    Abcam antibodies for TRIM23
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for TRIM23
    LSBio Antibodies in human, mouse, rat for TRIM23

    TRIM23 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRIM23
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for TRIM23 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 10):
     IPR003649 Bbox_C
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR

    Graphical View of Domain Structure for InterPro Entry P36406

    ProtoNet protein and cluster: P36406

    4 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003649 B-box
    IPB006688 ADP-ribosylation factor


    UniProtKB/Swiss-Prot: TRI23_HUMAN, P36406
    Domain: The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity
    Similarity: In the C-terminal section; belongs to the small GTPase superfamily. Arf family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with TRIM23           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI23_HUMAN, P36406
    Function: Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein
    UL144, participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled
    activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the
    cholera toxin catalytic subunit

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA8700863
    GO:0004842ubiquitin-protein ligase activity IDA15684077
    GO:0004871signal transducer activity ----
    GO:0005515protein binding IPI16189514
    GO:0005525GTP binding IDA8700863
         
    Find genes that share ontologies with TRIM23           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM23
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRIM23

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM23
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM23

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRIM23:
    hsa-mir-215-5p (MIRT024310), hsa-mir-192-5p (MIRT026946), hsa-mir-455-5p (MIRT040741), hsa-mir-33a-5p (MIRT028184), hsa-mir-132-3p (MIRT021830)

    Block miRNA regulation of human, mouse, rat TRIM23 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM23 (see all 26):
    hsa-miR-30c hsa-miR-137 hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-200a hsa-miR-128 hsa-miR-30d hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidTRIM23 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRIM23
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM23

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRIM23

    Clone
    Products:
         
    OriGene clones in human, mouse for TRIM23 (see all 18)
    OriGene ORF clones in mouse, rat for TRIM23
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TRIM23 (NM_033228)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM23
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM23

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TRIM23
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRIM23 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM23


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRI23_HUMAN, P36406: Endomembrane system. Golgi apparatus membrane. Lysosome membrane. Note=Membrane-associated
    with the Golgi complex and lysosomal structures
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    lysosome5
    vacuole5
    cytosol3
    nucleus3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IDA9671726
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005765lysosomal membrane IDA9671726

    Find genes that share ontologies with TRIM23           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: TRI23_HUMAN, P36406
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM23: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TRIM23

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRIM23 (P364061, 2, 3 ENSP000002315244) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GEMP550401, 2, 3, ENSP000002975964EBI-740098,EBI-744104 MINT-66445 I2D: score=5 STRING: ENSP00000297596
    FLAD1Q8NFF52, 3, ENSP000002921804MINT-66299 I2D: score=5 STRING: ENSP00000292180
    LNX1Q8TBB12, 3, ENSP000002639254MINT-67458 I2D: score=5 STRING: ENSP00000263925
    TRIM23P364061, 2EBI-740098,EBI-740098 MINT-66134
    TRIM31Q9BZY93, ENSP000003659244I2D: score=2 STRING: ENSP00000365924
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS8473324
    GO:0006886intracellular protein transport ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----

    Find genes that share ontologies with TRIM23           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM23 (TRI23)

    3 Novoseek inferred chemical compound relationships for TRIM23 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 42.5 4 9020091 (3), 16413270 (1)
    adp 37.4 4 9671726 (2)
    atp 17.8 2 15684077 (1), 16413270 (1)



    Find genes that share compounds with TRIM23           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRIM23 gene (3 alternative transcripts): 
    NM_001656.3  NM_033227.2  NM_033228.2  

    Unigene Cluster for TRIM23:

    Tripartite motif containing 23
    Hs.792  [show with all ESTs]
    Unigene Representative Sequence: NM_001656
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000231524(uc003jtw.3 uc003jtx.3 uc003jty.3) ENST00000381018
    ENST00000274327 ENST00000508808 ENST00000506400 ENST00000505205 ENST00000513794

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRIM23 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM23 (see all 26):
    hsa-miR-30c hsa-miR-137 hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-200a hsa-miR-128 hsa-miR-30d hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidTRIM23 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRIM23
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM23
    Clone
    Products:
         
    OriGene clones in human, mouse for TRIM23 (see all 18)
    OriGene ORF clones in mouse, rat for TRIM23
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TRIM23 (NM_033228)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM23
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM23
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRIM23
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM23
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM23
      QuantiTect SYBR Green Assays in human, mouse, rat TRIM23
      QuantiFast Probe-based Assays in human, mouse, rat TRIM23

    Additional mRNA sequence: 

    AF230397.1 AF230398.1 AF230399.1 AK292814.1 BC022510.1 L04510.1 

    9 DOTS entries:

    DT.446269  DT.100754324  DT.100021171  DT.100021172  DT.100754323  DT.100693545  DT.120812687  DT.91691406 
    DT.102824239 

    Selected AceView cDNA sequences (see all 96):

    AL527955 BM725267 BM547031 AF230397 L04510 NM_033228 F09406 BC022510 
    F11746 AI021991 BM677710 NM_033227 NM_001656 BX107879 T08981 AI077521 
    T08980 BM452300 AL563015 AU137144 AI744410 AL121038 AF230398 BG026654 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM23    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14
    SP1:                                            -                                   -     -               
    SP2:                                            -                                         -               
    SP3:                                            -                                                         
    SP4:                          -                                                                           
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for TRIM23

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAGGCCTT
    TRIM23 Expression
    About this image


    TRIM23 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    TRIM23 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM23 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.792
        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM23: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TRIM23
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM23
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM23
    QuantiTect SYBR Green Assays in human, mouse, rat TRIM23
    QuantiFast Probe-based Assays in human, mouse, rat TRIM23
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM23

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRIM23 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim231 , 5 tripartite motif-containing 231, 5 91.5(n)1
    97.81(a)1
      13 (56.35 cM)5
    810031  NM_030731.31  NP_109656.11 
     1041787975 
    chicken
    (Gallus gallus)
    Aves TRIM231 tripartite motif containing 23 82.93(n)
    94.08(a)
      427164  XM_424752.4  XP_424752.2 
    lizard
    (Anolis carolinensis)
    Reptilia TRIM236
    tripartite motif containing 23
    92(a)
    1 ↔ 1
    2(10704893-10726538)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia trim231 tripartite motif containing 23 78.05(n)
    89.37(a)
      100490191  XM_002934206.2  XP_002934252.2 
    zebrafish
    (Danio rerio)
    Actinopterygii trim231 tripartite motif containing 23 76.68(n)
    92.23(a)
      767706  NM_001076644.1  NP_001070112.1 
    worm
    (Caenorhabditis elegans)
    Secernentea arc-11 arc-1 49.15(n)
    38.28(a)
      174525  NM_063688.5  NP_496089.3 


    ENSEMBL Gene Tree for TRIM23 (if available)
    TreeFam Gene Tree for TRIM23 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM23 gene
    ARL22  ARL5B2  ENSG000002730032  ARL5C2  ARF42  ENSG000002728222  ARF52  ARF12  
    ARL32  ARL5A2  ARF32  ARF62  
    Selected SIMAP similar genes for TRIM23 using alignment to 4 protein entries:     TRI23_HUMAN (see all proteins) (see all similar genes):
    ARF1    ARF3    ARF6    ARL14    ARL2    ARL5B
    ARL4D    ARL11    ARL6    ARL4C    ARL4A    ARL8A
    ARL8B    RANP1    ARFRP1    ARL15    SAR1A    TRIM3

    Find genes that share paralogs with TRIM23           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM23 (see all 640)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs106108451,2
    C--64818331(+) tatct-/GTTT  
            
    aacaa
    3 -- int10--------
    rs606626761,2
    F--64885086(+) ATACTA/GTGTTT 3 -- ds50011Minor allele frequency- G:0.14WA 118
    rs432141,2
    C,F,O,A,H--64885295(+) ATGTGG/ACCTAT 3 -- ds500127Minor allele frequency- A:0.27NS EA NA WA 2890
    rs1903921181,2
    --64885612(+) ACTACA/GGCTAT 3 -- ut310--------
    rs1826051941,2
    --64885798(+) AATAGC/GAGCTT 3 -- ut310--------
    rs1875833521,2
    --64885874(+) AGGCAA/CAATTT 3 -- ut310--------
    rs1914353731,2
    --64885884(+) TTTCAA/GCTGTG 3 -- ut310--------
    rs2464001,2
    C,F,H--64885885(-) ACACAA/GTTGAA 3 -- ut31 ese319Minor allele frequency- G:0.50MN EA NS NA WA CSA 2436
    rs133613921,2
    C,F,H--64885979(+) TTCTTC/AAATTA 3 -- ut31 trp39Minor allele frequency- A:0.01NS EA NA WA 1194
    rs1421179581,2
    C--64886045(+) AGTTAC/TTGAAA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for TRIM23 (64885507 - 64921802 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TRIM23: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM23
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM23

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601747    OMIM disorders: --

    1 disease for TRIM23:    
    About MalaCards
    cholera


    Find genes that share disorders with TRIM23           About GenesLikeMe

    1 Novoseek inferred disease relationship for TRIM23 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholera 62.4 1 16413270 (1)


    Export disorders for TRIM23 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM23 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with TRIM23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl- terminal ADP-ribosylation factor domain. (PubMed id 8473324)1, 2, 3 Mishima K.... Vaughan M. (J. Biol. Chem. 1993)
    2. Localization of ADP-ribosylation factor domain protein 1 (ARD1) in lysosomes and Golgi apparatus. (PubMed id 9671726)1, 2, 9 Vitale N.... Vaughan M. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    3. E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP- ribosylation factor domain protein 1). (PubMed id 15684077)1, 2, 9 Vichi A.... Vaughan M. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    4. Specific functional interaction of human cytohesin-1 and ADP- ribosylation factor domain protein (ARD1). (PubMed id 10748148)1, 2, 9 Vitale N.... Vaughan M. (J. Biol. Chem. 2000)
    5. Identification of TRIM23 as a cofactor involved in the regulation of NF-kappaB by human cytomegalovirus. (PubMed id 19176615)1, 2 Poole E.... Sinclair J. (J. Virol. 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2 Reymond A.... Ballabio A. (EMBO J. 2001)
    8. Identification of lysosomal and Golgi localization signals in GAP and ARF domains of ARF domain protein 1. (PubMed id 10982851)1, 9 Vitale N....Vaughan M. (Mol. Cell. Biol. 2000)
    9. Identification of human protein interaction domains using an ORFeome-based yeast two-hybrid fragment library. (PubMed id 23718855)1 Waaijers S....Boxem M. (J. Proteome Res. 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 373 HGNC: 660 AceView: TRIM23 Ensembl:ENSG00000113595 euGenes: HUgn373
    ECgene: TRIM23 H-InvDB: TRIM23

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRIM23 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM23 gene:
    Search GeneIP for patents involving TRIM23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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