Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM22 Gene

protein-coding   GIFtS: 56
GCID: GC11P005667

tripartite motif containing 22

(Previous name: tripartite motif-containing 22 )
 Explore 26 diseases affiliated with
TRIM22 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRIM22    

Aliases
for TRIM22 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tripartite Motif Containing 221 2     E3 Ubiquitin-Protein Ligase TRIM222
STAF501 2 3 5     Staf-503
RNF941 2 3     Stimulated Trans-Acting Factor (50 KDa)2
GPSTAF501 2     Tripartite Binding Motif 222
Tripartite Motif-Containing 221 2     Tripartite Motif Protein TRIM222
Tripartite Motif-Containing Protein 222 3     EC 6.3.2.-3
50 KDa-Stimulated Trans-Acting Factor2 3     Staf-503
RING Finger Protein 942 3     EC 6.3.28

External Ids:    HGNC: 163791   Entrez Gene: 103462   Ensembl: ENSG000001322747   OMIM: 6065595   UniProtKB: Q8IYM93   

Export aliases for TRIM22 gene to outside databases

Previous GC identifers: GC11P006459 GC11P006013 GC11P005670 GC11P005675 GC11P005371


Summaries
for TRIM22 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TRIM22:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to
the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR
promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: TRI22_HUMAN, Q8IYM9
Function: Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part
be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of
HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core
promoter. May have E3 ubiquitin-protein ligase activity

Gene Wiki entry for TRIM22


Genomic Views
for TRIM22 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM22 gene promoter:
         c-Fos   AP-1   p53   JunB   Fra-1   FosB   IRF-1   IRF-2   JunD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRIM22 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15

TRIM22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM22 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P005667:  view genomic region     (about GC identifiers)

Start:
 5,710,919 bp from pter      End:
 5,758,319 bp from pter
Size:
 47,401 bases      Orientation:
 plus strand

Proteins
for TRIM22 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TRI22_HUMAN, Q8IYM9 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM22  
Size: 498 amino acids; 56947 Da
Subunit: Interacts with HIV-1 Gag polyprotein; this interaction seems to reduce gag production or virus budding.
Interacts with EMCV protease 3C; this interaction leads to viral protease ubiquitination
Subcellular location: Cytoplasm. Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Localizes predominanltly into the
nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell
cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and
completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies
Sequence caution: Sequence=CAA57684.1; Type=Frameshift; Positions=439;
Secondary accessions: Q05CQ0 Q15521
Alternative splicing: 2 isoforms:  Q8IYM9-1   Q8IYM9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIM22: NX_Q8IYM9

Post-translational modifications:

  • Auto-ubiquitinated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IYM9

    • 4 DME Specific Peptides for TRIM22 (Q8IYM9)
     GYWVIGL  CPICLEL  CGHSFCQACITA  PLSLDCGHSFCQAC 

    TRIM22 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186502.1  NP_006065.2  

    ENSEMBL proteins: 
     ENSP00000369299   ENSP00000400417   ENSP00000393250   ENSP00000396849   ENSP00000388994  
     ENSP00000406412   ENSP00000409991   ENSP00000404204  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: TRIM22
    OriGene Custom Protein Services for TRIM22 
    GenScript Custom Purified and Recombinant Proteins Services for TRIM22
    Novus Biologicals TRIM22 Protein
    Novus Biologicals TRIM22 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TRIM22

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0015030Cajal body IEA--


    TRIM22 for ontologies           About GeneDecksing



    TRIM22 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 4): TRIM22
    OriGene Custom Antibody Services for TRIM22 
    GenScript Custom Superior Antibodies Services for TRIM22
    Novus Biologicals TRIM22 Antibodies
    Search for Antibodies for TRIM22 at Abcam  
    Uscn Antibodies for TRIM22
    Search ThermoFisher Antibodies for TRIM22

    Assay Products for TRIM22: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRIM22
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TRIM22

    Protein Domains /
    Families
    for TRIM22 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRIM22 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt
     IPR000315 Znf_B-box

    Graphical View of Domain Structure for InterPro Entry Q8IYM9

    ProtoNet protein and cluster: Q8IYM9

    3 Blocks protein families:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature


    UniProtKB/Swiss-Prot: TRI22_HUMAN, Q8IYM9
    Domain: The C-terminal SPRY domain is required for the transcriptional suppressor activity, probably by mediating
    correct nuclear localization. Residues 491-494 are essential for nuclear localization and nuclear bodies formation
    Domain: The RING domain is essential for antiviral activity and for TRIM22 nuclear bodies (NB) formation but is not
    necessary for nuclear localization
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    Function
    for TRIM22 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TRI22_HUMAN, Q8IYM9
    Function: Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part
    be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of
    HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core
    promoter. May have E3 ubiquitin-protein ligase activity
    Induction: By interferons alpha and beta. Up-regulated by p53/TP53. Dramatically induced by progesterone in
    MDA-MB-231-derived ABC28 cells and T47D cells

    Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

    miRNA
    Products:            		 OriGene 3'-UTR Clone: TRIM22
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM22
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TRIM22
    SwitchGear 3'UTR luciferase reporter plasmid: TRIM22 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM22
    OriGene shRNA RFP: TRIM22
    OriGene siRNA: TRIM22
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM22

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TRIM22

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM22
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM22 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM22 (NM_001199573)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM22 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TRIM22
    Search LifeMap BioReagents cell lines for TRIM22

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM22

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS7797467
    GO:0003714transcription corepressor activity TAS7797467
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--


    TRIM22 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TRIM22:
     Decreased viability of wild-ty 


    Pathways & Interactions
    for TRIM22 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: TRI22_HUMAN, Q8IYM9
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRIM22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for TRIM22 (Q8IYM92, 3 ENSP000003692994) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CICQ96RK02, 3, ENSP000001607404MINT-2868247 I2D: score=3 STRING: ENSP00000160740
    REREQ9P2R62, 3, ENSP000003386294MINT-2868266 I2D: score=3 STRING: ENSP00000338629
    USP7Q930092, 3, ENSP000003435354MINT-2868285 I2D: score=3 STRING: ENSP00000343535
    TAF7Q155453, ENSP000003127094I2D: score=1 STRING: ENSP00000312709
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent TAS7797467
    GO:0006955immune response TAS7797467
    GO:0009615response to virus TAS7797467
    GO:0016567protein ubiquitination IEA--


    TRIM22 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRIM22 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRIM22 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM22
    10/33 Novoseek chemical compound relationships for TRIM22 gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenocysteine 48.7 18 11568435 (2), 11118223 (2), 18344183 (1), 16230358 (1) (see all 7)
    chloramphenicol 39.7 3 8035808 (1), 7565752 (1), 9271387 (1)
    adenylate 31.2 3 16356263 (1), 7926790 (1), 17426127 (1)
    pyrimidine 17.5 2 8289396 (1), 8385318 (1)
    cyclic amp 15.9 2 17382944 (1), 8381225 (1)
    potassium permanganate 15.3 1 11875059 (1)
    neomycin 7.7 1 8464738 (1)
    actinomycin d 6.01 1 20083226 (1)
    testosterone 4.85 1 7685765 (1)
    acetylcholine 4.62 1 9593756 (1)

    Search CenterWatch for drugs/clinical trials and news about TRIM22 / TRI22 

    Transcripts
    for TRIM22 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRIM22 gene (2 alternative transcripts): 
    NM_001199573.1  NM_006074.4  

    Unigene Clusters for TRIM22:

    Tripartite motif containing 22
    Hs.501778  [show with all ESTs], Hs.684559
    Unigene Representative Sequences: NM_006074, AL360187
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379965(uc001mbr.3 uc009yes.3 uc010qzm.2 uc009yet.2)
    ENST00000425490 ENST00000460454 ENST00000454828 ENST00000414641 ENST00000480395
    ENST00000414897 ENST00000493494 ENST00000450670 ENST00000429063(uc001mbs.1)
    ENST00000444844(uc009yev.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TRIM22
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM22
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TRIM22
    SwitchGear 3'UTR luciferase reporter plasmid: TRIM22 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM22
    OriGene shRNA RFP: TRIM22
    OriGene siRNA: TRIM22
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM22
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM22
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM22 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM22 (NM_001199573)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM22 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM22
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TRIM22
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM22
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM22

    Additional cDNA sequence: AL360187.1 

    13 DOTS entries:

    DT.91766812  DT.92043530  DT.95075706  DT.86547837  DT.91886000  DT.99999322  DT.40247603  DT.95089664 
    DT.120723330  DT.121124138  DT.40114934  DT.91766811  DT.91896545 

    24/218 AceView cDNA sequences (see all 218):

    CK903249 AI365477 AI276347 AJ713628 AL596979 BG055702 AI570753 AI582973 
    BM456871 BE161953 AA835773 BU674315 AI358824 BM994144 BQ879600 C01739 
    BG501979 CR593076 AA360854 CA447609 AI783503 BF594198 AI082207 CF265095 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM22    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
    SP1:              -           -                     
    SP2:              -           -           -         
    SP3:                          -                     
    SP4:              -                                 


    ECgene alternative splicing isoforms for TRIM22

    Expression
    for TRIM22 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTCTCTCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TRIM22 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleMature Granulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    CyT49 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See TRIM22 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM22

    SOURCE GeneReport for Unigene clusters: Hs.501778 Hs.684559

    UniProtKB/Swiss-Prot: TRI22_HUMAN, Q8IYM9
    Tissue specificity: Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal
    levels in other tissues

        SABiosciences Expression via Pathway-Focused PCR Array including TRIM22: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM22
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TRIM22
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM22
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM22
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM22

    Orthologs
    for TRIM22 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM22 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia TRIM586
    		 --
    		 32(a)
    		 1 → many
    		 GL343252.1(1250786-1269672)
    zebrafish
    (Danio rerio)    		 Actinopterygii trim476
    		 tripartite motif containing 47
    		 23(a)
    		 possible ortholog
    		 10(26752552-26762609)


    ENSEMBL Gene Tree for TRIM22 (if available)
    TreeFam Gene Tree for TRIM22 (if available) 

    Paralogs
    for TRIM22 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM22 gene
    TRIM42  TRIM72  TRIM262  TRIM392  TRIM342  TRIML12  TRIM272  TRIM582  
    TRIM682  TRIM102  TRIM152  TRIM602  TRIM172  TRIM52  TRIM62  TRIM6-TRIM342  
    TRIM212  TRIM382  TRIM39-RPP212  TRIM112  
    18/30 SIMAP similar genes for TRIM22 using alignment to 11 protein entries:     TRI22_HUMAN (see all proteins) (see all similar genes):
    TRIM5    TRIM6-TRIM34    TRIM34    TRIM6    DKFZp781D1977    TRIM31
    TRIM68    TRIM39    TRIM61    DKFZp686F23130    TRIM26    TRIM21
    BRCA1    MEFV    TRIM27    TRIM48    TRIM49C    TRIM49

    TRIM22 for paralogs           About GeneDecksing



    Genomic Variants
    for TRIM22 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/557 NCBI SNPs in TRIM22 are shown (see all 557)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1882441761,2
    		--5708825(+) TTAGAA/GCATAG 2 -- us2k10--------
    rs1931904191,2
    		--5708972(+) TAATAC/GTTCAT 2 -- us2k10--------
    rs1839078581,2
    		--5708989(+) AATCAA/GACCAG 2 -- us2k10--------
    rs14985531,2
    		C,F,A,H,--5709028(+) CCAGAC/TGAGAA 2 -- us2k140Minor allele frequency- N:0.00MN NS EA NA WA CSA 3864
    rs1871915531,2
    		--5709168(+) ACTCCA/GGAAAA 2 -- us2k10--------
    rs1912556771,2
    		--5709176(+) AAAAAA/CACATT 2 -- us2k10--------
    rs110387191,2
    		H--5709188(+) ACTCAC/TTGAGC 2 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs763072211,2
    		F,--5709405(+) GCAAAT/ACCAAA 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1171618181,2
    		--5709456(+) GTCAAC/TGTTAT 2 -- us2k11Minor allele frequency- T:0.01EA 120
    rs14985541,2
    		C,F,H,--5709457(+) TCAACG/ATTATA 2 -- us2k120Minor allele frequency- A:0.02NS EA NA WA 2328

    HapMap Linkage Disequilibrium report for TRIM22 (5710919 - 5758319 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for TRIM22
         3 CNVs: 34458 3836 71264
         1 Indel: 71263
    Human Gene Mutation Database (HGMD): TRIM22

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM22
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM22

    Disorders / Diseases
    for TRIM22 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRIM22 for disorders           About GeneDecksing

    OMIM gene information: 606559    OMIM disorders: --

    20/26 diseases for TRIM22 (see all 26):    About MalaCards
    mhc class ii deficiency    bare lymphocyte syndrome    congenital erythropoietic porphyria    beta thalassemia
    x inactivation    thalassemia    porphyria    cystic fibrosis
    hepatitis c    hepatitis b    nephrotic syndrome    rubella
    colon cancer    fibrosis    hepatitis    breast cancer
    myeloma    choriocarcinoma    retinoblastoma    immunodeficiency

    1 disease from the University of Copenhagen DISEASES database for TRIM22:
    Rubella

    10/24 Novoseek disease relationships for TRIM22 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bare lymphocyte syndrome 53.4 1 12542744 (1)
    erythroleukemia 48.1 2 19118563 (1)
    beta-thalassemia 20.3 1 1984681 (1)
    thalassemia 15 2 11559936 (1), 17148589 (1)
    immunodeficiency 13.3 6 2124274 (1), 9806546 (1), 2068104 (1), 10079298 (1) (see all 5)
    aids 1.44 1 17633198 (1)
    breast carcinoma 0 1 8758927 (1)
    virus infection 0 2 8380090 (1), 1319057 (1)
    genetic disorder 0 1 9700205 (1)
    necrosis 0 1 10882233 (1)

    Human Genome Epidemiology (HuGE) Navigator: TRIM22 (1 document)

    Export disorders for TRIM22 gene to outside databases

    Publications
    for TRIM22 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM22 gene, integrated from 9 sources (see all 256):
    (articles sorted by number of sources associating them with TRIM22)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2, 3 Reymond A.... Ballabio A. (2001)
    2. Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain. (PubMed id 19585648)1, 2 Gao B.... Xiong S. (2009)
    3. B30.2/SPRY domain in tripartite motif-containing 22 is essential for the formation of distinct nuclear bodies. (PubMed id 19481078)1, 2 Sivaramakrishnan G.... Lin V.C. (2009)
    4. TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus. (PubMed id 19218198)1, 2 Eldin P....Mechti N. (2009)
    5. Identification of TRIM22 as a RING finger E3 ubiquitin ligase. (PubMed id 18656448)1, 2 Duan Z....Xiong S. (2008)
    6. The interferon response inhibits HIV particle production by induction of TRIM22. (PubMed id 18389079)1, 2 Barr S.D.... Bushman F.D. (2008)
    7. Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells. (PubMed id 15064739)1, 2 Obad S....Gullberg U. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The interferon-inducible Staf50 gene is downregulated during T cell costimulation by CD2 and CD28. (PubMed id 11096452)1, 3 Gongora C....Mechti N. (2000)
    10. Molecular cloning of a new interferon-induced factor that represses human immunodeficiency virus type 1 long terminal repeat expression. (PubMed id 7797467)1, 2 Tissot C. and Mechti N. (1995)

    External Searches for TRIM22 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TRIM22 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10346 HGNC: 16379 AceView: TRIM22 Ensembl:ENSG00000132274 euGenes: HUgn10346
    ECgene: TRIM22 H-InvDB: TRIM22

    Other Databases showing TRIM22 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TRIM22 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM22 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TRIM22 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TRIM22 gene:
    Search GeneIP for patents involving TRIM22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TRIM22 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for TRIM22   OriGene shRNA RFP for TRIM22  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM22   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM22  
     OriGene Protein Over-expression Lysate for TRIM22   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TRIM22   OriGene 3'-UTR Clone for TRIM22  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM22   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM22  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRIM22   OriGene Custom Protein Services for TRIM22  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIM22
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM22
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM22
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM22
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM22
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM22
     GenScript Custom Purified and Recombinant Proteins Services for TRIM22 GenScript cDNA clones with any tag delivered in your preferred vector for TRIM22
     GenScript Custom Assay Services for TRIM22 GenScript Custom Superior Antibodies Services for TRIM22
     GenScript Custom overexpressing Cell Line Services for TRIM22 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TRIM22 promoter
     Search Chromatin IP Primers for TRIM22
     RT2 qPCR Primer Assay in human, mouse / rat TRIM22
     GNC Network for TRIM22
     SABiosciences PCR Arrays including human, mouse, rat TRIM22
     Search Tocris compounds for TRIM22
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TRIM22 antibodies
     TRIM22 proteins
     TRIM22 lysates
     Search for Antibodies for TRIM22 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TRIM22
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TRIM22 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TRIM22
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM22
     SwitchGear 3'UTR luciferase reporter plasmids for TRIM22
     SwitchGear Promoter luciferase reporter plasmids for TRIM22
     Search ThermoFisher Antibodies for TRIM22
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM22
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      TRIM22 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4