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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM22 Gene

protein-coding   GIFtS: 59
GCID: GC11P005667

Tripartite Motif Containing 22

(Previous name: tripartite motif-containing 22)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tripartite Motif Containing 221 2     E3 Ubiquitin-Protein Ligase TRIM222
STAF502 3 5     staf-502
Tripartite Motif-Containing 221 2     Stimulated Trans-Acting Factor (50 KDa)2
Tripartite Motif-Containing Protein 222 3     Tripartite Binding Motif 222
50 KDa-Stimulated Trans-Acting Factor2 3     Tripartite Motif Protein TRIM222
RNF942 3     EC 6.3.2.-3
RING Finger Protein 942 3     Staf-503
GPSTAF502     EC 6.3.28

External Ids:    HGNC: 163791   Entrez Gene: 103462   Ensembl: ENSG000001322747   OMIM: 6065595   UniProtKB: Q8IYM93   

Export aliases for TRIM22 gene to outside databases

Previous GC identifers: GC11P006459 GC11P006013 GC11P005670 GC11P005675 GC11P005371


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRIM22 Gene:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes
to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the
HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral
effects. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Dec 2010)

GeneCards Summary for TRIM22 Gene: 
TRIM22 (tripartite motif containing 22) is a protein-coding gene. Diseases associated with TRIM22 include mhc class ii deficiency, and congenital erythropoietic porphyria. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and ligase activity. An important paralog of this gene is TRIM7.

UniProtKB/Swiss-Prot: TRI22_HUMAN, Q8IYM9
Function: Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in
part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the
replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional
repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity

Gene Wiki entry for TRIM22 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM22 gene promoter:
         c-Fos   AP-1   p53   JunB   Fra-1   FosB   IRF-1   IRF-2   JunD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM22 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15

TRIM22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM22 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P005667:  view genomic region     (about GC identifiers)

Start:
5,710,817 bp from pter      End:
5,758,319 bp from pter
Size:
47,503 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRI22_HUMAN, Q8IYM9 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM22  
Size: 498 amino acids; 56947 Da
Subunit: Interacts with HIV-1 Gag polyprotein; this interaction seems to reduce gag production or virus budding.
Interacts with EMCV protease 3C; this interaction leads to viral protease ubiquitination
Subcellular location: Cytoplasm. Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Localizes predominanltly into
the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during
cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the
S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal
bodies
Sequence caution: Sequence=CAA57684.1; Type=Frameshift; Positions=439;
Secondary accessions: Q05CQ0 Q15521
Alternative splicing: 2 isoforms:  Q8IYM9-1   Q8IYM9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIM22: NX_Q8IYM9

Explore proteomics data for TRIM22 at MOPED 

Post-translational modifications:

  • UniProtKB: Auto-ubiquitinated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IYM9

  • 4 DME Specific Peptides for TRIM22 (Q8IYM9)
     GYWVIGL  CPICLEL  CGHSFCQACITA  PLSLDCGHSFCQAC 

    TRIM22 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRIM22 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001186502.1  NP_006065.2  

    ENSEMBL proteins: 
     ENSP00000369299   ENSP00000400417   ENSP00000393250   ENSP00000396849   ENSP00000388994  
     ENSP00000406412   ENSP00000409991   ENSP00000404204  

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    Novus Biologicals TRIM22 Protein
    Novus Biologicals TRIM22 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIM22 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0015030Cajal body IEA--

    TRIM22 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    5/8 InterPro protein domains (see all 8):
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt
     IPR000315 Znf_B-box

    Graphical View of Domain Structure for InterPro Entry Q8IYM9

    ProtoNet protein and cluster: Q8IYM9

    3 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature


    UniProtKB/Swiss-Prot: TRI22_HUMAN, Q8IYM9
    Domain: The C-terminal SPRY domain is required for the transcriptional suppressor activity, probably by mediating
    correct nuclear localization. Residues 491-494 are essential for nuclear localization and nuclear bodies
    formation
    Domain: The RING domain is essential for antiviral activity and for TRIM22 nuclear bodies (NB) formation but is
    not necessary for nuclear localization
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    TRIM22 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI22_HUMAN, Q8IYM9
    Function: Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in
    part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the
    replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional
    repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity
    Induction: By interferons alpha and beta. Up-regulated by p53/TP53. Dramatically induced by progesterone in
    MDA-MB-231-derived ABC28 cells and T47D cells

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS7797467
    GO:0003714transcription corepressor activity TAS7797467
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
         
    TRIM22 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TRIM22:
     Decreased viability of wild-ty 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: TRI22_HUMAN, Q8IYM9
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRIM22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for TRIM22 (Q8IYM92, 3 ENSP000003692994) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CICQ96RK02, 3, ENSP000001607404MINT-2868247 I2D: score=3 STRING: ENSP00000160740
    REREQ9P2R62, 3, ENSP000003386294MINT-2868266 I2D: score=3 STRING: ENSP00000338629
    USP7Q930092, 3, ENSP000003435354MINT-2868285 I2D: score=3 STRING: ENSP00000343535
    TAF7Q155453, ENSP000003127094I2D: score=1 STRING: ENSP00000312709
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent TAS7797467
    GO:0006955immune response TAS7797467
    GO:0009615response to virus TAS7797467
    GO:0016567protein ubiquitination IEA--

    TRIM22 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRIM22 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM22 (TRI22)

    10/33 Novoseek inferred chemical compound relationships for TRIM22 gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenocysteine 48.7 18 11568435 (2), 11118223 (2), 18344183 (1), 16230358 (1) (see all 7)
    chloramphenicol 39.7 3 8035808 (1), 7565752 (1), 9271387 (1)
    adenylate 31.2 3 16356263 (1), 7926790 (1), 17426127 (1)
    pyrimidine 17.5 2 8289396 (1), 8385318 (1)
    cyclic amp 15.9 2 17382944 (1), 8381225 (1)
    potassium permanganate 15.3 1 11875059 (1)
    neomycin 7.7 1 8464738 (1)
    actinomycin d 6.01 1 20083226 (1)
    testosterone 4.85 1 7685765 (1)
    acetylcholine 4.62 1 9593756 (1)

    Search CenterWatch for drugs/clinical trials and news about TRIM22 / TRI22

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRIM22 gene (2 alternative transcripts): 
    NM_001199573.1  NM_006074.4  

    Unigene Clusters for TRIM22:

    Tripartite motif containing 22
    Hs.501778  [show with all ESTs], Hs.684559
    Unigene Representative Sequences: NM_006074, AL360187
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379965(uc001mbr.3 uc009yes.3 uc010qzm.2 uc009yet.2)
    ENST00000425490 ENST00000460454 ENST00000454828 ENST00000414641 ENST00000480395
    ENST00000414897 ENST00000493494 ENST00000450670 ENST00000429063(uc001mbs.1)
    ENST00000444844(uc009yev.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: AL360187.1 

    13 DOTS entries:

    DT.91766812  DT.92043530  DT.95075706  DT.86547837  DT.91886000  DT.99999322  DT.40247603  DT.95089664 
    DT.120723330  DT.121124138  DT.40114934  DT.91766811  DT.91896545 

    24/218 AceView cDNA sequences (see all 218):

    BG501979 AA720586 CK903249 BU674315 BG055702 BU682946 AJ713628 AA835773 
    AI365477 BQ007525 AI570753 C01739 AI582973 BX093905 AW026304 AA360854 
    CF265095 BQ879600 CA447609 BM456871 BF594198 BE161953 AI783503 BM994144 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM22    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
    SP1:              -           -                     
    SP2:              -           -           -         
    SP3:                          -                     
    SP4:              -                                 


    ECgene alternative splicing isoforms for TRIM22

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM22 expression in normal human tissues (normalized intensities)      TRIM22 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCTCTCCT
    TRIM22 Expression
    About this image


    TRIM22 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (WA09)
     
     Ovary (Reproductive System)
             Mature Granulosa Cells Antral Follicle
     
     Bone (Muscoskeletal System)
             Human fetal bone marrow-derived mesenchymal stromal cells
     
     Lymph (Hematopoietic System)
             Lymphnode   
     
     Thymus (Hematopoietic System)

    See TRIM22 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM22

    SOURCE GeneReport for Unigene clusters: Hs.501778 Hs.684559

    UniProtKB/Swiss-Prot: TRI22_HUMAN, Q8IYM9
    Tissue specificity: Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at
    basal levels in other tissues

        SABiosciences Expression via Pathway-Focused PCR Array including TRIM22: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for TRIM22 gene from 1/2 species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia TRIM221 tripartite motif containing 22 79.08(n)
    67(a)
      485284  XM_542402.4  XP_542402.2 


    ENSEMBL Gene Tree for TRIM22 (if available)
    TreeFam Gene Tree for TRIM22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM22 gene
    TRIM72  TRIM42  TRIM262  TRIM392  TRIM342  TRIM272  TRIM582  TRIM682  
    TRIM102  TRIM152  TRIM602  TRIM172  TRIM52  TRIM62  TRIM6-TRIM342  TRIM212  
    TRIM382  TRIM112  TRIM39-RPP212  
    18/29 SIMAP similar genes for TRIM22 using alignment to 11 protein entries:     TRI22_HUMAN (see all proteins) (see all similar genes):
    TRIM5    TRIM6-TRIM34    TRIM34    TRIM6    DKFZp781D1977    TRIM39
    TRIM68    TRIM31    TRIM61    DKFZp686F23130    TRIM26    TRIM21
    BRCA1    MEFV    TRIM27    TRIM48    TRIM49C    TRIM17

    TRIM22 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/689 SNPs in TRIM22 are shown (see all 689)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1882441761,2
    --5708825(+) TTAGAA/GCATAG 2 -- us2k10--------
    rs1931904191,2
    --5708972(+) TAATAC/GTTCAT 2 -- us2k10--------
    rs1839078581,2
    --5708989(+) AATCAA/GACCAG 2 -- us2k10--------
    rs14985531,2
    C,F,A,H--5709028(+) CCAGAC/TGAGAA 2 -- us2k140Minor allele frequency- N:0.00MN NS EA NA WA CSA 3864
    rs1871915531,2
    --5709168(+) ACTCCA/GGAAAA 2 -- us2k10--------
    rs1912556771,2
    --5709176(+) AAAAAA/CACATT 2 -- us2k10--------
    rs110387191,2
    H--5709188(+) ACTCAC/TTGAGC 2 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs763072211,2
    F--5709405(+) GCAAAT/ACCAAA 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1171618181,2
    F--5709456(+) GTCAAC/TGTTAT 2 -- us2k11Minor allele frequency- T:0.01EA 120
    rs14985541,2
    C,F,H--5709457(+) TCAACG/ATTATA 2 -- us2k120Minor allele frequency- A:0.02NS EA NA WA 2328

    HapMap Linkage Disequilibrium report for TRIM22 (5710817 - 5758319 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TRIM22:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2744065CNV Deletion23290073
    esv2673191CNV Deletion23128226
    nsv896949CNV Loss21882294
    nsv896939CNV Loss21882294
    nsv896948CNV Loss21882294
    esv29417CNV Loss19812545
    esv988030CNV Gain20482838
    dgv341e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): TRIM22
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM22
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606559    OMIM disorders: --

    20/25 diseases for TRIM22 (see all 25):    About MalaCards
    mhc class ii deficiency    congenital erythropoietic porphyria    bare lymphocyte syndrome    beta thalassemia
    thalassemia    rubella    porphyria    hepatitis b
    nephrotic syndrome    cystic fibrosis    hepatitis c    choriocarcinoma
    hepatitis    colon cancer    retinoblastoma    myeloma
    hypoxia    mental retardation    melanoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for TRIM22:
    Rubella

    TRIM22 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/24 Novoseek inferred disease relationships for TRIM22 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bare lymphocyte syndrome 53.4 1 12542744 (1)
    erythroleukemia 48.1 2 19118563 (1)
    beta-thalassemia 20.3 1 1984681 (1)
    thalassemia 15 2 11559936 (1), 17148589 (1)
    immunodeficiency 13.3 6 2124274 (1), 9806546 (1), 2068104 (1), 10079298 (1) (see all 5)
    aids 1.44 1 17633198 (1)
    breast carcinoma 0 1 8758927 (1)
    virus infection 0 2 8380090 (1), 1319057 (1)
    genetic disorder 0 1 9700205 (1)
    necrosis 0 1 10882233 (1)

    Genetic Association Database (GAD): TRIM22
    Human Genome Epidemiology (HuGE) Navigator: TRIM22 (1 document)

    Export disorders for TRIM22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM22 gene, integrated from 9 sources (see all 261):
    (articles sorted by number of sources associating them with TRIM22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2, 3 Reymond A.... Ballabio A. (2001)
    2. Rubella vaccine-induced cellular immunity: evidence o f associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes. (PubMed id 19902255)1, 4 Ovsyannikova I.G....Poland G.A. (2010)
    3. Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain. (PubMed id 19585648)1, 2 Gao B.... Xiong S. (2009)
    4. B30.2/SPRY domain in tripartite motif-containing 22 is essential for the formation of distinct nuclear bodies. (PubMed id 19481078)1, 2 Sivaramakrishnan G.... Lin V.C. (2009)
    5. TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus. (PubMed id 19218198)1, 2 Eldin P....Mechti N. (2009)
    6. Identification of TRIM22 as a RING finger E3 ubiquitin ligase. (PubMed id 18656448)1, 2 Duan Z....Xiong S. (2008)
    7. The interferon response inhibits HIV particle production by induction of TRIM22. (PubMed id 18389079)1, 2 Barr S.D.... Bushman F.D. (2008)
    8. Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells. (PubMed id 15064739)1, 2 Obad S....Gullberg U. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The interferon-inducible Staf50 gene is downregulated during T cell costimulation by CD2 and CD28. (PubMed id 11096452)1, 3 Gongora C....Mechti N. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10346 HGNC: 16379 AceView: TRIM22 Ensembl:ENSG00000132274 euGenes: HUgn10346
    ECgene: TRIM22 H-InvDB: TRIM22

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM22 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRIM22 gene:
    Search GeneIP for patents involving TRIM22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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