Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIM22 Gene

Aliases for TRIM22 Gene

  • Tripartite Motif Containing 22 2 3
  • STAF50 3 4 6
  • Tripartite Motif-Containing Protein 22 3 4
  • 50 KDa-Stimulated Trans-Acting Factor 3 4
  • Tripartite Motif-Containing 22 2 3
  • RING Finger Protein 94 3 4
  • Staf-50 3 4
  • RNF94 3 4
  • Stimulated Trans-Acting Factor (50 KDa) 3
  • E3 Ubiquitin-Protein Ligase TRIM22 3
  • Tripartite Motif Protein TRIM22 3
  • Tripartite Binding Motif 22 3
  • EC 6.3.2.- 4
  • GPSTAF50 3
  • EC 6.3.2 64

External Ids for TRIM22 Gene

Summaries for TRIM22 Gene

Entrez Gene Summary for TRIM22 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

GeneCards Summary for TRIM22 Gene

TRIM22 (Tripartite Motif Containing 22) is a Protein Coding gene. Diseases associated with TRIM22 include hiv-1 and mhc class ii deficiency. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and ligase activity. An important paralog of this gene is TRIM58.

UniProtKB/Swiss-Prot for TRIM22 Gene

  • Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.

Gene Wiki entry for TRIM22 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM22 Gene

Genomics for TRIM22 Gene

Genomic Location for TRIM22 Gene

Start:
5,689,587 bp from pter
End:
5,737,089 bp from pter
Size:
47,503 bases
Orientation:
Plus strand

Genomic View for TRIM22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM22 Gene

Regulatory Elements for TRIM22 Gene

Proteins for TRIM22 Gene

  • Protein details for TRIM22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYM9-TRI22_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM22
    Protein Accession:
    Q8IYM9
    Secondary Accessions:
    • Q05CQ0
    • Q15521

    Protein attributes for TRIM22 Gene

    Size:
    498 amino acids
    Molecular mass:
    56947 Da
    Quaternary structure:
    • Interacts with HIV-1 Gag polyprotein; this interaction seems to reduce gag production or virus budding. Interacts with EMCV protease 3C; this interaction leads to viral protease ubiquitination.
    SequenceCaution:
    • Sequence=CAA57684.1; Type=Frameshift; Positions=439; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM22 Gene

Proteomics data for TRIM22 Gene at MOPED

Selected DME Specific Peptides for TRIM22 Gene

Post-translational modifications for TRIM22 Gene

Domains for TRIM22 Gene

Gene Families for TRIM22 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

UniProtKB/Swiss-Prot:

TRI22_HUMAN
Domain:
  • The C-terminal SPRY domain is required for the transcriptional suppressor activity, probably by mediating correct nuclear localization. Residues 491-494 are essential for nuclear localization and nuclear bodies formation:
    • Q8IYM9
  • The RING domain is essential for antiviral activity and for TRIM22 nuclear bodies (NB) formation but is not necessary for nuclear localization:
    • Q8IYM9
  • Contains 1 B30.2/SPRY domain.:
    • Q8IYM9
Family:
  • Belongs to the TRIM/RBCC family.:
    • Q8IYM9
Similarity:
  • Contains 1 B box-type zinc finger.:
    • Q8IYM9
  • Contains 1 RING-type zinc finger.:
    • Q8IYM9
genes like me logo Genes that share domains with TRIM22: view

Function for TRIM22 Gene

Molecular function for TRIM22 Gene

UniProtKB/Swiss-Prot Function: Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.
UniProtKB/Swiss-Prot Induction: By interferons alpha and beta. Up-regulated by p53/TP53. Dramatically induced by progesterone in MDA-MB-231-derived ABC28 cells and T47D cells.

Enzyme Numbers (IUBMB) for TRIM22 Gene

Gene Ontology (GO) - Molecular Function for TRIM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 7797467
GO:0003714 transcription corepressor activity TAS 7797467
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRIM22: view

Phenotypes for TRIM22 Gene

genes like me logo Genes that share phenotypes with TRIM22: view

miRNA for TRIM22 Gene

miRTarBase miRNAs that target TRIM22

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIM22 Gene

Localization for TRIM22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM22 Gene

Cytoplasm. Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Localizes predominanltly into the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM22 Gene COMPARTMENTS Subcellular localization image for TRIM22 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for TRIM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 17156811
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 17156811
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRIM22: view

Pathways for TRIM22 Gene

SuperPathways for TRIM22 Gene

No Data Available

UniProtKB/Swiss-Prot Q8IYM9-TRI22_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 7797467
GO:0006955 immune response TAS 7797467
GO:0009615 response to virus TAS 7797467
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with TRIM22: view

No data available for Pathways by source for TRIM22 Gene

Compounds for TRIM22 Gene

(33) Novoseek inferred chemical compound relationships for TRIM22 Gene

Compound -log(P) Hits PubMed IDs
selenocysteine 48.7 9
chloramphenicol 39.7 3
adenylate 31.2 3
pyrimidine 17.5 2
cyclic amp 15.9 2
genes like me logo Genes that share compounds with TRIM22: view

Transcripts for TRIM22 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM22 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for TRIM22 Gene

GeneLoc Exon Structure for
TRIM22
ECgene alternative splicing isoforms for
TRIM22

Expression for TRIM22 Gene

mRNA expression in normal human tissues for TRIM22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM22 Gene

This gene is overexpressed in Whole Blood (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRIM22 Gene

SOURCE GeneReport for Unigene cluster for TRIM22 Gene Hs.501778

mRNA Expression by UniProt/SwissProt for TRIM22 Gene

Q8IYM9-TRI22_HUMAN
Tissue specificity: Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal levels in other tissues.
genes like me logo Genes that share expressions with TRIM22: view

Orthologs for TRIM22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM22 36
  • 99.6 (n)
  • 99 (a)
TRIM22 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM22 36
  • 79.08 (n)
  • 67 (a)
TRIM22 37
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim34b 37
  • 54 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 37
  • 30 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 31 (a)
OneToMany
Species with no ortholog for TRIM22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM22 Gene

ENSEMBL:
Gene Tree for TRIM22 (if available)
TreeFam:
Gene Tree for TRIM22 (if available)

Paralogs for TRIM22 Gene

genes like me logo Genes that share paralogs with TRIM22: view

Variants for TRIM22 Gene

Sequence variations from dbSNP and Humsavar for TRIM22 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2178 -- 5,701,938(+) ACTTG(C/T)TCTTT intron-variant
rs2179 -- 5,701,877(+) TGTTA(C/G)AGCAA intron-variant
rs8433 -- 5,710,408(-) ATAAC(A/G)TGGAT utr-variant-3-prime
rs885002 -- 5,688,953(-) TCTAT(C/T)GTATT upstream-variant-2KB
rs999295 -- 5,709,018(-) GGATA(C/G/T)GGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM22 Gene

Variant ID Type Subtype PubMed ID
nsv896939 CNV Loss 21882294
nsv896948 CNV Loss 21882294
nsv896949 CNV Loss 21882294
esv2673191 CNV Deletion 23128226
esv2744065 CNV Deletion 23290073
esv988030 CNV Gain 20482838
esv29417 CNV Loss 19812545
dgv341e1 CNV Complex 17122850

Relevant External Links for TRIM22 Gene

HapMap Linkage Disequilibrium report
TRIM22
Human Gene Mutation Database (HGMD)
TRIM22

Disorders for TRIM22 Gene

(1) University of Copenhagen DISEASES for TRIM22 Gene

(24) Novoseek inferred disease relationships for TRIM22 Gene

Disease -log(P) Hits PubMed IDs
bare lymphocyte syndrome 53.4 1
erythroleukemia 48.1 1
beta-thalassemia 20.3 1
thalassemia 15 2
immunodeficiency 13.3 5

Relevant External Links for TRIM22

Genetic Association Database (GAD)
TRIM22
Human Genome Epidemiology (HuGE) Navigator
TRIM22
genes like me logo Genes that share disorders with TRIM22: view

No data available for UniProtKB/Swiss-Prot for TRIM22 Gene

Publications for TRIM22 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3 4
  2. Molecular cloning of a new interferon-induced factor that represses human immunodeficiency virus type 1 long terminal repeat expression. (PMID: 7797467) Tissot C. … Mechti N. (J. Biol. Chem. 1995) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells. (PMID: 15064739) Obad S. … Gullberg U. (Oncogene 2004) 3 4
  5. The interferon response inhibits HIV particle production by induction of TRIM22. (PMID: 18389079) Barr S.D. … Bushman F.D. (PLoS Pathog. 2008) 3 4

Products for TRIM22 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TRIM22
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM22
    • Block miRNA regulation of TRIM22 using miScript Target Protectors

    Sources for TRIM22 Gene

    Back to Top

    Content