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TRIM21 Gene

protein-coding   GIFtS: 63
GCID: GC11M004406

Tripartite Motif Containing 21

(Previous names: Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen...)
(Previous symbol: SSA1)
  See TRIM21-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 211 2     SS-A2 3
SSA11 2 3 5     RING Finger Protein 812 3
RO522 3 5     Ro/SSA2
Sjogren Syndrome Antigen A1 (52kDa, Ribonucleoprotein Autoantigen SS-A/Ro)1 2     SSA2
Tripartite Motif-Containing 211 2     E3 Ubiquitin-Protein Ligase TRIM212
Sjoegren Syndrome Type A Antigen2 3     ro(SS-A)2
Tripartite Motif-Containing Protein 212 3     Sicca Syndrome Antigen A2
52 KDa Ribonucleoprotein Autoantigen Ro/SS-A2 3     EC 6.3.2.-3
52 KDa Ro Protein2 3     Ro(SS-A)3
RNF812 3     

External Ids:    HGNC: 113121   Entrez Gene: 67372   Ensembl: ENSG000001321097   OMIM: 1090925   UniProtKB: P194743   

Export aliases for TRIM21 gene to outside databases

Previous GC identifers: GC11M004363 GC11M004064


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIM21 Gene:
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding
domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the
RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA
particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with
Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have
been described but the full-length nature of only one has been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRIM21 Gene:
TRIM21 (tripartite motif containing 21) is a protein-coding gene. Diseases associated with TRIM21 include lupus erythematosus, and neonatal lupus erythematosus. GO annotations related to this gene include ubiquitin-protein ligase activity and RNA binding. An important paralog of this gene is TRIM7.

UniProtKB/Swiss-Prot: RO52_HUMAN, P19474
Function: E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and
UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the
ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF
(SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A
TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187'
phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will
negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen
recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal
degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway.
Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in
macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of
DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single
polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood
cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these
proteins is their ability to bind HY RNAs.2

Gene Wiki entry for TRIM21 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM21 gene promoter:
         AML1a   SREBP-1c   Pax-2   Pax-2a   Evi-1   SREBP-1b   AREB6   c-Rel   SREBP-1a   Pax-2b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM21 promoter sequence
   Search Chromatin IP Primers for TRIM21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.5-p15.3

TRIM21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM21 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M004406:  view genomic region     (about GC identifiers)

Start:
4,406,127 bp from pter      End:
4,414,926 bp from pter
Size:
8,800 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RO52_HUMAN, P19474 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM21  
Size: 475 amino acids; 54170 Da
Subunit: Interacts (via C-terminus) with IRF8 (via C-terminus) (By similarity). Component of a SCF(SKP2)-like
complex containing CUL1, SKP1, TRIM21 and SKP2. Interacts with CALR, CUL1, FBXW11, HSPA5, IKBKB, IRF3, SKP1 and
VCP. Interacts with SKP2; the interaction with SKP2 does not depend on an intact F-box domain. Interacts (via
N-terminus and C-terminus) with DCP2 (via N-terminus and C-terminus)
1 PDB 3D structure from and Proteopedia for TRIM21:
2IWG (3D)    
Secondary accessions: Q5XPV5 Q96RF8
Alternative splicing: 2 isoforms:  P19474-1   P19474-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIM21: NX_P19474

Explore proteomics data for TRIM21 at MOPED

Post-translational modifications: 

  • Autoubiquitinated; does not lead to its proteasomal degradation. Deubiquitinated by USP4; leading to its
    stabilization1
  • Ubiquitination2 at Lys260
  • Modification sites at PhosphoSitePlus

  • See TRIM21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003132.2  
    ENSEMBL proteins: 
     ENSP00000434053   ENSP00000254436   ENSP00000444045  
    Reactome Protein details: P19474

    TRIM21 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TRIM21 

    TRIM21 Antibody Products:

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    TRIM21 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for TRIM21 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 12):
     IPR006574 PRY
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR020457 Znf_B-box_chordata

    Graphical View of Domain Structure for InterPro Entry P19474

    ProtoNet protein and cluster: P19474

    4 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: RO52_HUMAN, P19474
    Domain: The coiled-coil is necessary for the cytoplasmic localization. The B30.2/SPRY domain is necessary for the
    cytoplasmic localization, the interaction with IRF3 and for the IRF3-driven interferon beta promoter activity.
    The RING-type zinc finger is necessary for ubiquitination and for the IRF3-driven interferon beta promoter
    activity. Interacts with SKP2 and CUL1 in a RING finger-independent manner
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with TRIM21           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RO52_HUMAN, P19474
    Function: E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and
    UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the
    ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF
    (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A
    TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187'
    phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will
    negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen
    recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal
    degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway.
    Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in
    macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of
    DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single
    polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood
    cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these
    proteins is their ability to bind HY RNAs.2
    Induction: Up-regulated by isoform 2 of XBP1

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding IEA--
    GO:0004842ubiquitin-protein ligase activity IDA16297862
    GO:0005515protein binding IPI11461834
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with TRIM21           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TRIM21:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Trim21):
     hematopoietic system  homeostasis/metabolism  immune system  integument  mortality/aging 
     renal/urinary system 

    Find genes that share phenotypes with TRIM21           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM21
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRIM21

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM21
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM21

    miRNA
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    Block miRNA regulation of human, mouse, rat TRIM21 using miScript Target Protectors
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    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TRIM21
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM21

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: TRIM21 (NM_003141)
    Sino Biological Human cDNA Clone for TRIM21
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM21

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM21


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RO52_HUMAN, P19474: Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Enters the nucleus upon exposure to nitric
    oxide. Localizes to small dot- or rod-like structures in the cytoplasm, called cytoplasmic bodies (P-body) that
    are located underneath the plasma membrane and also diffusely in the cytoplasm and are highly motil in cells.
    Cytoplasmic bodies are located along the microtubules and do not share the same cytoplasmic bodies with TRIM5.
    Colocalizes with DCP2 in P-body
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex ----
    GO:0000932cytoplasmic mRNA processing body IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with TRIM21           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRIM21 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    2Cytosolic sensors of pathogen-associated DNA
    Cytosolic sensors of pathogen-associated DNA0.38
    STING mediated induction of host immune responses0.00
    Regulation of innate immune responses to cytosolic DNA0.00
    3RNA Polymerase I Promoter Opening
    Systemic lupus erythematosus0.40


    Find genes that share SuperPaths with TRIM21           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Reactome Pathways for TRIM21
        Antigen processing: Ubiquitination & Proteasome degradation
    STING mediated induction of host immune responses
    Regulation of innate immune responses to cytosolic DNA


    1 Kegg Pathway  (Kegg details for TRIM21):
        Systemic lupus erythematosus

    UniProtKB/Swiss-Prot: RO52_HUMAN, P19474
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRIM21
    Interactions:

        GeneGlobe Interaction Network for TRIM21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRIM21 (P194741, 2, 3 ENSP000002544364) via UniProtKB, MINT, STRING, and/or I2D (see all 642)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    NIF3L1Q9GZT82, 3, ENSP000003863944MINT-67290 I2D: score=5 STRING: ENSP00000386394
    CUL1Q136162, 3, ENSP000003268044MINT-7947479 I2D: score=2 STRING: ENSP00000326804
    HDAC1Q135472, 3, ENSP000003626494MINT-7947479 I2D: score=1 STRING: ENSP00000362649
    UBA5Q9GZZ92, 3MINT-7947479 I2D: score=1 
    YWHAZP631042, 3, ENSP000003095034MINT-51020 I2D: score=4 STRING: ENSP00000309503
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA16297862
    GO:0006513protein monoubiquitination IDA16297862
    GO:0007049cell cycle IEA--
    GO:0016567protein ubiquitination IDA16472766
    GO:0031648protein destabilization IMP16880511

    Find genes that share ontologies with TRIM21           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM21 (RO52)

    5 Novoseek inferred chemical compound relationships for TRIM21 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cardiolipin 42.8 2 2293908 (1), 15225372 (1)
    leucine 36.4 5 14987746 (2), 15630133 (1)
    2-mercaptoethanol 28.9 1 12761219 (1)
    oligonucleotide 0 1 10364476 (1)
    zinc 0 4 10364476 (2), 9588745 (1)



    Find genes that share compounds with TRIM21           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRIM21 gene: 
    NM_003141.3  

    Unigene Cluster for TRIM21:

    Tripartite motif containing 21
    Hs.532357  [show with all ESTs]
    Unigene Representative Sequence: NM_003141
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533692 ENST00000254436(uc001lyy.1) ENST00000543625
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TRIM21
      QuantiFast Probe-based Assays in human, mouse, rat TRIM21

    Additional mRNA sequence: 

    AK225564.1 AY742713.1 BC010861.1 M34551.1 M62800.1 

    5 DOTS entries:

    DT.213907  DT.100779337  DT.95214115  DT.99966324  DT.102823209 

    Selected AceView cDNA sequences (see all 97):

    BQ009912 AW663379 BM474980 BU616734 BM974766 CK906134 AA159361 CK906135 
    BX340999 AW014509 AA300987 BM127233 CA309266 BE910692 BM693791 BU619381 
    T56733 BU738231 BU957579 AA524717 BG258617 BC010861 BF593766 AA490242 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCTGCCTT
    TRIM21 Expression
    About this image


    TRIM21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    TRIM21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM21 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532357

    UniProtKB/Swiss-Prot: RO52_HUMAN, P19474
    Tissue specificity: Isoform 1 and isoform 2 are expressed in fetal and adult heart and fetal lung

        Custom PCR Arrays for TRIM21
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM21 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim211 , 5 tripartite motif-containing 211, 5 77.54(n)1
    70.65(a)1
      7 (54.76 cM)5
    208211  NM_009277.31  NP_033303.31 
     1025579225 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    36(a)
    1 → many
    19(353752-359048) ENSGALG00000000865
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    40(a)
    1 → many
    GL343252.1(1250717-1269864)


    ENSEMBL Gene Tree for TRIM21 (if available)
    TreeFam Gene Tree for TRIM21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM21 gene
    TRIM72  TRIM42  TRIM392  TRIM342  TRIML12  TRIM272  TRIM582  TRIM682  
    TRIM602  TRIM222  TRIM172  TRIM52  TRIM62  TRIM6-TRIM342  TRIM382  TRIM112  
    TRIM39-RPP212  
    Selected SIMAP similar genes for TRIM21 using alignment to 3 protein entries:     RO52_HUMAN (see all proteins) (see all similar genes):
    ERMAP    TRIM68    TRIM5    TRIM11    TRIM41    TRIM58
    TRIM6    TRIM39R    TRIM6-TRIM34    TRIM34    TRIM39    BT3.3
    TRIM38    DKFZp686F23130    DKFZp781D1977    TRIML1    BTNL9    MEFV

    Find genes that share paralogs with TRIM21           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM21 (see all 401)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs118252521,2
    C,F,A,H--4339791(+) ggtacG/Atgtgc 1 -- us2k16Minor allele frequency- A:0.40NA CSA 10
    rs1863307441,2
    --4405630(+) GAGAAA/GTAACA 1 -- ds50010--------
    rs1429452171,2
    C--4405756(+) AGAACA/GTGGAC 1 -- ds50010--------
    rs1911258601,2
    --4405784(+) TGTGAC/GGGTCA 1 -- ds50010--------
    rs1477134951,2
    --4405895(+) GATCAC/GAGCCC 1 -- ds50010--------
    rs1388691211,2
    C--4405912(+) CTTCT-/ATCA  
            
    ATCAC
    1 -- ds50010--------
    rs2004933641,2
    --4405915(+) CTATC-/AACCAC 1 -- ds50010--------
    rs1828733641,2
    --4405975(+) TTGACC/TTGGGT 1 -- ds50010--------
    rs1875501731,2
    --4406066(+) AATCAC/TATTCA 1 -- ds50010--------
    rs1908126031,2
    --4406209(+) AAAGAC/TGACAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TRIM21 (4406127 - 4414926 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TRIM21:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832054CNV Gain17160897
    dgv1021n71CNV Gain21882294
    nsv896911CNV Gain21882294
    nsv896908CNV Gain21882294
    nsv428248CNV Gain+Loss18775914
    essv17026CNV CNV17122850
    dgv338e1CNV Complex17122850
    nsv469800CNV Complex16826518

    Human Gene Mutation Database (HGMD): TRIM21
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM21
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 109092    OMIM disorders: --

    9 diseases for TRIM21:    
    About MalaCards
    lupus erythematosus    neonatal lupus erythematosus    congenital heart block    sjogren's syndrome
    cardiac conduction defect    rheumatic disease    cutaneous lupus erythematosus    subacute cutaneous lupus erythematosus
    systemic lupus erythematosus

    6 diseases from the University of Copenhagen DISEASES database for TRIM21:
    Congenital heart block     Lupus erythematosus     Connective tissue disease     Sjogren's syndrome
    Myositis     Rheumatic disease

    Find genes that share disorders with TRIM21           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TRIM21 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    congenital heart block 87.7 13 14987746 (3), 16830880 (2), 2031658 (1), 2396870 (1) (see all 7)
    sjogrens syndrome 77.2 12 12410795 (2), 10680747 (1), 12646630 (1), 8871672 (1) (see all 10)
    lupus erythematosus systemic 73.1 17 8310208 (2), 16356190 (1), 18022694 (1), 8714273 (1) (see all 15)
    lupus erythematosus cutaneous subacute 67.7 2 8823371 (1), 10584550 (1)
    lupus erythematosus 67.5 4 10680747 (1), 8823371 (1), 7774062 (1)
    autoimmune response 67.2 5 10587550 (2), 9218821 (1), 8871672 (1)
    sjogrens syndrome primary 66.8 7 11263778 (2), 16095123 (2), 8714273 (1), 12528117 (1) (see all 5)
    autoimmune diseases 60.9 10 10587550 (2), 2031658 (1), 18022694 (1), 10364476 (1) (see all 7)
    rheumatic diseases 57.9 1 15916807 (1)
    myopathies idiopathic inflammatory 54.7 1 9218821 (1)

    Genetic Association Database (GAD): TRIM21
    Human Genome Epidemiology (HuGE) Navigator: TRIM21 (4 documents)

    Export disorders for TRIM21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM21 gene, integrated from 10 sources (see all 179):
    (articles sorted by number of sources associating them with TRIM21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Autoantigen Ro52 is an E3 ubiquitin ligase. (PubMed id 16297862)1, 2, 9 Wada K. and Kamitani T. (Biochem. Biophys. Res. Commun. 2006)
    2. rs660 polymorphism in Ro52 (SSA1; TRIM21) is a marker for age-dependent tolerance induction and efficiency of alloimmunization in sickle cell disease. (PubMed id 19201475)1, 4, 9 Tatari-Calderone Z....Vukmanovic S. (Mol. Immunol. 2009)
    3. Ro52 functionally interacts with IgG1 and regulates its quality control via the ERAD system. (PubMed id 18022694)1, 2, 9 Takahata M....Hatakeyama S. (Mol. Immunol. 2008)
    4. Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity. (PubMed id 16316627)1, 2, 9 Wada K.... Kamitani T. (Biochem. Biophys. Res. Commun. 2006)
    5. A novel polymorphism of the SSA1 gene is associated with anti-SS-A/Ro52 autoantibody in Japanese patients with primary SjAPgren's syndrome. (PubMed id 16095123)1, 4, 9 Imanishi T....Kumagai S. (Clin. Exp. Rheumatol. 2005)
    6. Polymorphisms of the Ro52 gene associated with anti-Ro 52-kd autoantibodies in patients with primary SjAPgren's syndrome. (PubMed id 11263778)1, 4, 9 Nakken B....Bolstad A.I. (Arthritis Rheum. 2001)
    7. SSA/Ro52 autoantigen interacts with Dcp2 to enhance its decapping activity. (PubMed id 18361920)1, 2, 9 Yamochi T.... Morimoto C. (Biochem. Biophys. Res. Commun. 2008)
    8. The location of a disease-associated polymorphism and genomic structure of the human 52-kDa Ro/SSA locus (SSA1). (PubMed id 7713506)1, 2, 9 Tsugu H.... Frank M.B. (Genomics 1994)
    9. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    10. Dynamic movements of Ro52 cytoplasmic bodies along microtubules. (PubMed id 20013343)1, 2 Tanaka M.... Kamitani T. (Histochem. Cell Biol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6737 HGNC: 11312 AceView: SSA1 Ensembl:ENSG00000132109 euGenes: HUgn6737
    ECgene: TRIM21 Kegg: 6737 H-InvDB: TRIM21

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRIM21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM21 gene:
    Search GeneIP for patents involving TRIM21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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