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Aliases for TRIM21 Gene

Aliases for TRIM21 Gene

  • Tripartite Motif Containing 21 2 3
  • SSA1 3 4 6
  • RO52 3 4 6
  • Sjogren Syndrome Antigen A1 (52kDa, Ribonucleoprotein Autoantigen SS-A/Ro) 2 3
  • 52 KDa Ribonucleoprotein Autoantigen Ro/SS-A 3 4
  • Tripartite Motif-Containing Protein 21 3 4
  • Sjoegren Syndrome Type A Antigen 3 4
  • Tripartite Motif-Containing 21 2 3
  • RING Finger Protein 81 3 4
  • 52 KDa Ro Protein 3 4
  • Ro(SS-A) 3 4
  • RNF81 3 4
  • SS-A 3 4
  • E3 Ubiquitin-Protein Ligase TRIM21 3
  • Sicca Syndrome Antigen A 3
  • EC 6.3.2.- 4
  • Ro/SSA 3
  • SSA 3

External Ids for TRIM21 Gene

Previous HGNC Symbols for TRIM21 Gene

  • SSA1

Previous GeneCards Identifiers for TRIM21 Gene

  • GC11M004363
  • GC11M004064

Summaries for TRIM21 Gene

Entrez Gene Summary for TRIM21 Gene

  • This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM21 Gene

TRIM21 (Tripartite Motif Containing 21) is a Protein Coding gene. Diseases associated with TRIM21 include congenital heart block and sjogren's syndrome. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include RNA binding and ubiquitin-protein transferase activity. An important paralog of this gene is TRIM58.

UniProtKB/Swiss-Prot for TRIM21 Gene

  • E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B (Thr-187 phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2.

Gene Wiki entry for TRIM21 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM21 Gene

Genomics for TRIM21 Gene

Regulatory Elements for TRIM21 Gene

Genomic Location for TRIM21 Gene

Start:
4,384,897 bp from pter
End:
4,393,697 bp from pter
Size:
8,801 bases
Orientation:
Minus strand

Genomic View for TRIM21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM21 Gene

Proteins for TRIM21 Gene

  • Protein details for TRIM21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19474-RO52_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM21
    Protein Accession:
    P19474
    Secondary Accessions:
    • Q5XPV5
    • Q96RF8

    Protein attributes for TRIM21 Gene

    Size:
    475 amino acids
    Molecular mass:
    54170 Da
    Quaternary structure:
    • Interacts (via C-terminus) with IRF8 (via C-terminus) (By similarity). Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Interacts with CALR, CUL1, FBXW11, HSPA5, IKBKB, IRF3, SKP1 and VCP. Interacts with SKP2; the interaction with SKP2 does not depend on an intact F-box domain. Interacts (via N-terminus and C-terminus) with DCP2 (via N-terminus and C-terminus).

    Three dimensional structures from OCA and Proteopedia for TRIM21 Gene

    Alternative splice isoforms for TRIM21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM21 Gene

Proteomics data for TRIM21 Gene at MOPED

Post-translational modifications for TRIM21 Gene

  • Autoubiquitinated; does not lead to its proteasomal degradation. Deubiquitinated by USP4; leading to its stabilization.
  • Ubiquitination at Lys260
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM21 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TRIM21 Gene

Domains for TRIM21 Gene

Gene Families for TRIM21 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Suggested Antigen Peptide Sequences for TRIM21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P19474

UniProtKB/Swiss-Prot:

RO52_HUMAN :
  • P19474
Domain:
  • The coiled-coil is necessary for the cytoplasmic localization. The B30.2/SPRY domain is necessary for the cytoplasmic localization, the interaction with IRF3 and for the IRF3-driven interferon beta promoter activity. The RING-type zinc finger is necessary for ubiquitination and for the IRF3-driven interferon beta promoter activity. Interacts with SKP2 and CUL1 in a RING finger-independent manner.
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM21: view

Function for TRIM21 Gene

Molecular function for TRIM21 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B (Thr-187 phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2.
UniProtKB/Swiss-Prot Induction: Up-regulated by isoform 2 of XBP1

Enzyme Numbers (IUBMB) for TRIM21 Gene

Gene Ontology (GO) - Molecular Function for TRIM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity IDA 16297862
GO:0005515 protein binding IPI 11461834
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM21: view
genes like me logo Genes that share phenotypes with TRIM21: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM21

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRIM21 Gene

Localization for TRIM21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM21 Gene

Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Enters the nucleus upon exposure to nitric oxide. Localizes to small dot- or rod-like structures in the cytoplasm, called cytoplasmic bodies (P-body) that are located underneath the plasma membrane and also diffusely in the cytoplasm and are highly motil in cells. Cytoplasmic bodies are located along the microtubules and do not share the same cytoplasmic bodies with TRIM5. Colocalizes with DCP2 in P-body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM21 Gene COMPARTMENTS Subcellular localization image for TRIM21 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for TRIM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IEA --
GO:0005622 intracellular --
GO:0005634 nucleus IDA 18845142
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with TRIM21: view

Pathways for TRIM21 Gene

genes like me logo Genes that share pathways with TRIM21: view

UniProtKB/Swiss-Prot P19474-RO52_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 16297862
GO:0006513 protein monoubiquitination IDA 16297862
GO:0007049 cell cycle IEA --
GO:0016567 protein ubiquitination IDA 16472766
GO:0019221 cytokine-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with TRIM21: view

Compounds for TRIM21 Gene

(5) Novoseek inferred chemical compound relationships for TRIM21 Gene

Compound -log(P) Hits PubMed IDs
cardiolipin 42.8 2
leucine 36.4 3
2-mercaptoethanol 28.9 1
oligonucleotide 0 1
zinc 0 3
genes like me logo Genes that share compounds with TRIM21: view

Transcripts for TRIM21 Gene

mRNA/cDNA for TRIM21 Gene

Unigene Clusters for TRIM21 Gene

Tripartite motif containing 21:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM21

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TRIM21

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM21 Gene

No ASD Table

Relevant External Links for TRIM21 Gene

GeneLoc Exon Structure for
TRIM21
ECgene alternative splicing isoforms for
TRIM21

Expression for TRIM21 Gene

mRNA expression in normal human tissues for TRIM21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM21 Gene

This gene is overexpressed in Whole Blood (9.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM21 Gene

SOURCE GeneReport for Unigene cluster for TRIM21 Gene Hs.532357

mRNA Expression by UniProt/SwissProt for TRIM21 Gene

P19474-RO52_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are expressed in fetal and adult heart and fetal lung
genes like me logo Genes that share expressions with TRIM21: view

In Situ Assay Products

Orthologs for TRIM21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM21 35
  • 99.51 (n)
  • 100 (a)
TRIM21 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM21 35
  • 83.76 (n)
  • 77.56 (a)
TRIM21 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM21 35
  • 83.01 (n)
  • 76.03 (a)
TRIM21 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim21 35
  • 77.54 (n)
  • 70.65 (a)
Trim21 16
Trim21 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim21 35
  • 77.61 (n)
  • 70.82 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
OneToMany
Species with no ortholog for TRIM21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM21 Gene

ENSEMBL:
Gene Tree for TRIM21 (if available)
TreeFam:
Gene Tree for TRIM21 (if available)

Paralogs for TRIM21 Gene

genes like me logo Genes that share paralogs with TRIM21: view

Variants for TRIM21 Gene

Sequence variations from dbSNP and Humsavar for TRIM21 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs15120 -- 4,385,055(-) ATCTT(C/G)ATCAA utr-variant-3-prime
rs760217 -- 4,388,905(+) CCTGT(C/T)CCCAC intron-variant
rs890419 -- 4,389,239(-) TGACC(A/G)GGTGG intron-variant
rs890420 -- 4,388,696(-) CAAAA(C/T)TGTGT intron-variant
rs915956 -- 4,388,667(-) GTGTG(C/T)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM21 Gene

Variant ID Type Subtype PubMed ID
essv17026 CNV CNV 17122850
nsv428248 CNV Gain+Loss 18775914
dgv338e1 CNV Complex 17122850
nsv832054 CNV Gain 17160897
nsv469800 CNV Complex 16826518
dgv1021n71 CNV Gain 21882294
nsv896908 CNV Gain 21882294
nsv896911 CNV Gain 21882294

Relevant External Links for TRIM21 Gene

HapMap Linkage Disequilibrium report
TRIM21
Human Gene Mutation Database (HGMD)
TRIM21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM21 Gene

Disorders for TRIM21 Gene

(17) Novoseek inferred disease relationships for TRIM21 Gene

Disease -log(P) Hits PubMed IDs
congenital heart block 87.7 10
sjogrens syndrome 77.2 11
lupus erythematosus systemic 73.1 16
lupus erythematosus cutaneous subacute 67.7 2
lupus erythematosus 67.5 3

Relevant External Links for TRIM21

Genetic Association Database (GAD)
TRIM21
Human Genome Epidemiology (HuGE) Navigator
TRIM21
genes like me logo Genes that share disorders with TRIM21: view

No data available for UniProtKB/Swiss-Prot for TRIM21 Gene

Publications for TRIM21 Gene

  1. The location of a disease-associated polymorphism and genomic structure of the human 52-kDa Ro/SSA locus (SSA1). (PMID: 7713506) Tsugu H. … Frank M.B. (Genomics 1994) 3 4 23
  2. Polymorphisms of the Ro52 gene associated with anti-Ro 52-kd autoantibodies in patients with primary SjAPgren's syndrome. (PMID: 11263778) Nakken B. … Bolstad A.I. (Arthritis Rheum. 2001) 3 23 48
  3. A novel polymorphism of the SSA1 gene is associated with anti-SS-A/Ro52 autoantibody in Japanese patients with primary SjAPgren's syndrome. (PMID: 16095123) Imanishi T. … Kumagai S. (Clin. Exp. Rheumatol. 2005) 3 23 48
  4. Autoantigen Ro52 is an E3 ubiquitin ligase. (PMID: 16297862) Wada K. … Kamitani T. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  5. Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity. (PMID: 16316627) Wada K. … Kamitani T. (Biochem. Biophys. Res. Commun. 2006) 3 4 23

Products for TRIM21 Gene

Sources for TRIM21 Gene

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