Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIM21 Gene

Aliases for TRIM21 Gene

  • Tripartite Motif Containing 21 2 3 5
  • Sjogren Syndrome Antigen A1 (52kDa, Ribonucleoprotein Autoantigen SS-A/Ro) 2 3
  • 52 KDa Ribonucleoprotein Autoantigen Ro/SS-A 3 4
  • RING-Type E3 Ubiquitin Transferase TRIM21 3 4
  • Tripartite Motif-Containing Protein 21 3 4
  • Sjoegren Syndrome Type A Antigen 3 4
  • RING Finger Protein 81 3 4
  • 52 KDa Ro Protein 3 4
  • Ro(SS-A) 3 4
  • RNF81 3 4
  • SSA1 3 4
  • RO52 3 4
  • SS-A 3 4
  • E3 Ubiquitin-Protein Ligase TRIM21 3
  • Tripartite Motif-Containing 21 2
  • Sicca Syndrome Antigen A 3
  • EC 2.3.2.27 4
  • Ro/SSA 3
  • SSA 3

External Ids for TRIM21 Gene

Previous HGNC Symbols for TRIM21 Gene

  • SSA1

Previous GeneCards Identifiers for TRIM21 Gene

  • GC11M004363
  • GC11M004064

Summaries for TRIM21 Gene

Entrez Gene Summary for TRIM21 Gene

  • This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM21 Gene

TRIM21 (Tripartite Motif Containing 21) is a Protein Coding gene. Diseases associated with TRIM21 include Sjogren's Syndrome and Heart Block, Congenital. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include identical protein binding and ligase activity. An important paralog of this gene is TRIM6-TRIM34.

UniProtKB/Swiss-Prot for TRIM21 Gene

  • E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B (Thr-187 phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses (PubMed:26347139).

Gene Wiki entry for TRIM21 Gene

Additional gene information for TRIM21 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM21 Gene

Genomics for TRIM21 Gene

Regulatory Elements for TRIM21 Gene

Enhancers for TRIM21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H004493 1.3 FANTOM5 Ensembl ENCODE 9.7 -99.5 -99535 0 CTCF RB1 RAD21 YY1 FOSL1 CTBP1 EED SMC3 ZNF143 FOS OR52K2 OR52B4 TRIM21 OR51F1 OR52K1 OR52M2P
GH11H004455 1.2 FANTOM5 Ensembl ENCODE 7.8 -62.0 -61952 0 CTCF POLR2A MAX ETV6 MYC GABPA OR52K3P OR52K1 TRIM21 OR52K2
GH11H004392 1.2 FANTOM5 ENCODE 7.1 +0.2 232 1 HDAC1 TBP HDGF PKNOX1 RB1 SIN3A DMAP1 NFXL1 ZBTB40 RAD21 OR52K3P TRIM21 OR52K2 OR52B3P
GH11H004458 1 FANTOM5 Ensembl ENCODE 4.9 -66.6 -66611 3 CEBPG SPI1 OR52K3P OR52K1 OR52M1 TRIM21 OR52K2
GH11H003644 0.6 ENCODE 4.9 +748.7 748733 1 HDAC1 MEF2D ZFHX2 IKZF1 NR2C1 TRIM24 FOXA1 TRIM21 ART5 ENSG00000201279 GC11M003663
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM21 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036173 212 1401 HDAC1 TBP HDGF PKNOX1 RB1 SIN3A DMAP1 NFXL1 ZBTB40 RAD21

Genomic Location for TRIM21 Gene

Chromosome:
11
Start:
4,384,897 bp from pter
End:
4,393,712 bp from pter
Size:
8,816 bases
Orientation:
Minus strand

Genomic View for TRIM21 Gene

Genes around TRIM21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM21 Gene

Proteins for TRIM21 Gene

  • Protein details for TRIM21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19474-RO52_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM21
    Protein Accession:
    P19474
    Secondary Accessions:
    • Q5XPV5
    • Q96RF8

    Protein attributes for TRIM21 Gene

    Size:
    475 amino acids
    Molecular mass:
    54170 Da
    Quaternary structure:
    • Homotrimer (PubMed:17156811) (PubMed:26347139). Interacts (via C-terminus) with IRF8 (via C-terminus) (By similarity). Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Interacts with CALR, CUL1, FBXW11, HSPA5, IKBKB, IRF3, SKP1 and VCP. Interacts with SKP2; the interaction with SKP2 does not depend on an intact F-box domain. Interacts (via N-terminus and C-terminus) with DCP2 (via N-terminus and C-terminus). Interacts with ULK1, BECN1 and with ATG8 family members, including GABARAP, GABARAPL1, GABARAPL2 and MAP1LC3C/LC3C. Interacts with TRIM21 and SQSTM1/sequestosome 1. Interacts with IRF3 (PubMed:26347139).

    Three dimensional structures from OCA and Proteopedia for TRIM21 Gene

    Alternative splice isoforms for TRIM21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM21 Gene

Post-translational modifications for TRIM21 Gene

  • Autoubiquitinated; does not lead to its proteasomal degradation. Deubiquitinated by USP4; leading to its stabilization.
  • Ubiquitination at Lys260
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM21 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TRIM21 (TRIM21)
  • Cloud-Clone Corp. Antibodies for TRIM21

No data available for DME Specific Peptides for TRIM21 Gene

Domains & Families for TRIM21 Gene

Gene Families for TRIM21 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TRIM21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P19474

UniProtKB/Swiss-Prot:

RO52_HUMAN :
  • The coiled-coil is necessary for the cytoplasmic localization. The B30.2/SPRY domain is necessary for the cytoplasmic localization, the interaction with IRF3 and for the IRF3-driven interferon beta promoter activity. The RING-type zinc finger is necessary for ubiquitination and for the IRF3-driven interferon beta promoter activity. Interacts with SKP2 and CUL1 in a RING finger-independent manner.
  • Belongs to the TRIM/RBCC family.
Domain:
  • The coiled-coil is necessary for the cytoplasmic localization. The B30.2/SPRY domain is necessary for the cytoplasmic localization, the interaction with IRF3 and for the IRF3-driven interferon beta promoter activity. The RING-type zinc finger is necessary for ubiquitination and for the IRF3-driven interferon beta promoter activity. Interacts with SKP2 and CUL1 in a RING finger-independent manner.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM21: view

Function for TRIM21 Gene

Molecular function for TRIM21 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B (Thr-187 phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses (PubMed:26347139).
UniProtKB/Swiss-Prot Induction:
Up-regulated by isoform 2 of XBP1. Up-regulated by IFNG/interferon-gamma, with a peak after 2-4 hours of treatment in monocytes/macrophages.

Enzyme Numbers (IUBMB) for TRIM21 Gene

Phenotypes From GWAS Catalog for TRIM21 Gene

Gene Ontology (GO) - Molecular Function for TRIM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 8666824
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM21: view
genes like me logo Genes that share phenotypes with TRIM21: view

Animal Models for TRIM21 Gene

MGI Knock Outs for TRIM21:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TRIM21
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM21 Gene

Localization for TRIM21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM21 Gene

Cytoplasm. Cytoplasmic vesicle, autophagosome. Nucleus. Cytoplasm, P-body. Note=Enters the nucleus upon exposure to nitric oxide. Localizes to small dot- or rod-like structures in the cytoplasm, called cytoplasmic bodies (P-body) that are located underneath the plasma membrane and also diffusely in the cytoplasm and are highly motil in cells. Cytoplasmic bodies are located along the microtubules and do not share the same cytoplasmic bodies with TRIM5. Colocalizes with DCP2 in P-body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM21 gene
Compartment Confidence
nucleus 5
cytosol 5
endoplasmic reticulum 2
plasma membrane 1
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRIM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 18845142
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 16316627
genes like me logo Genes that share ontologies with TRIM21: view

Pathways & Interactions for TRIM21 Gene

genes like me logo Genes that share pathways with TRIM21: view

UniProtKB/Swiss-Prot P19474-RO52_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for TRIM21 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TRIM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0006513 protein monoubiquitination IDA 16297862
GO:0007049 cell cycle IEA --
GO:0010508 positive regulation of autophagy IMP 26347139
GO:0016567 protein ubiquitination IEA,IDA 16472766
genes like me logo Genes that share ontologies with TRIM21: view

Drugs & Compounds for TRIM21 Gene

(3) Drugs for TRIM21 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for TRIM21 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRIM21: view

Transcripts for TRIM21 Gene

mRNA/cDNA for TRIM21 Gene

Unigene Clusters for TRIM21 Gene

Tripartite motif containing 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TRIM21
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM21 Gene

No ASD Table

Relevant External Links for TRIM21 Gene

GeneLoc Exon Structure for
TRIM21
ECgene alternative splicing isoforms for
TRIM21

Expression for TRIM21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM21 Gene

This gene is overexpressed in Whole Blood (x9.0).

Protein differential expression in normal tissues from HIPED for TRIM21 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.5), Lymph node (11.0), Heart (9.4), and Monocytes (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM21 Gene



Protein tissue co-expression partners for TRIM21 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM21 Gene:

TRIM21

SOURCE GeneReport for Unigene cluster for TRIM21 Gene:

Hs.532357

mRNA Expression by UniProt/SwissProt for TRIM21 Gene:

P19474-RO52_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are expressed in fetal and adult heart and fetal lung.

Evidence on tissue expression from TISSUES for TRIM21 Gene

  • Blood(4.5)
  • Pancreas(4.1)
  • Skin(2.6)
  • Spleen(2.2)
  • Heart(2.1)
  • Liver(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with TRIM21: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM21 Gene

Orthologs for TRIM21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM21 33 34
  • 99.51 (n)
cow
(Bos Taurus)
Mammalia TRIM21 33 34
  • 83.76 (n)
dog
(Canis familiaris)
Mammalia TRIM21 33 34
  • 83.01 (n)
rat
(Rattus norvegicus)
Mammalia Trim21 33
  • 77.61 (n)
mouse
(Mus musculus)
Mammalia Trim21 33 16 34
  • 77.54 (n)
chicken
(Gallus gallus)
Aves -- 34
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
OneToMany
Species where no ortholog for TRIM21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM21 Gene

ENSEMBL:
Gene Tree for TRIM21 (if available)
TreeFam:
Gene Tree for TRIM21 (if available)

Paralogs for TRIM21 Gene

Variants for TRIM21 Gene

Sequence variations from dbSNP and Humsavar for TRIM21 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000177576 -- 4,387,836(+) CATAA(A/G)TAAAT intron-variant
rs1000202384 -- 4,386,012(+) CTGAC(C/T)TCTGA intron-variant
rs1000274970 -- 4,392,887(+) GAGAA(A/G)TTATA intron-variant
rs1000284862 -- 4,393,161(+) CCTAA(A/G)CAGCC intron-variant
rs1000378272 -- 4,391,093(+) TTGAA(A/T)AGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM21 Gene

Variant ID Type Subtype PubMed ID
dgv1023n100 CNV loss 25217958
dgv1582n54 CNV loss 21841781
dgv1583n54 CNV loss 21841781
dgv180e214 CNV gain 21293372
dgv181e214 CNV loss 21293372
esv2759797 CNV gain+loss 17122850
esv3625179 CNV loss 21293372
esv3891912 CNV gain+loss 25118596
nsv1053120 CNV gain 25217958
nsv428248 CNV gain+loss 18775914
nsv469800 CNV gain+loss 16826518
nsv553159 CNV gain 21841781
nsv553162 CNV gain 21841781
nsv832054 CNV gain 17160897

Variation tolerance for TRIM21 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM21 Gene

Human Gene Mutation Database (HGMD)
TRIM21
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM21 Gene

Disorders for TRIM21 Gene

MalaCards: The human disease database

(37) MalaCards diseases for TRIM21 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sjogren's syndrome
  • sicca syndrome
heart block, congenital
  • congenital heart block
subacute cutaneous lupus erythematosus
  • lupus erythematosus cutaneous subacute
idiopathic inflammatory myopathy
  • myositis
rheumatic disease
  • collagen diseases
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIM21

Genetic Association Database (GAD)
TRIM21
Human Genome Epidemiology (HuGE) Navigator
TRIM21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM21
genes like me logo Genes that share disorders with TRIM21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM21 Gene

Publications for TRIM21 Gene

  1. rs660 polymorphism in Ro52 (SSA1; TRIM21) is a marker for age-dependent tolerance induction and efficiency of alloimmunization in sickle cell disease. (PMID: 19201475) Tatari-Calderone Z … Vukmanovic S (Molecular immunology 2009) 3 22 45 60
  2. SSA/Ro52 autoantigen interacts with Dcp2 to enhance its decapping activity. (PMID: 18361920) Yamochi T … Morimoto C (Biochemical and biophysical research communications 2008) 3 4 22 60
  3. Ro52 functionally interacts with IgG1 and regulates its quality control via the ERAD system. (PMID: 18022694) Takahata M … Hatakeyama S (Molecular immunology 2008) 3 4 22 60
  4. Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity. (PMID: 16316627) Wada K … Kamitani T (Biochemical and biophysical research communications 2006) 3 4 22 60
  5. Autoantigen Ro52 is an E3 ubiquitin ligase. (PMID: 16297862) Wada K … Kamitani T (Biochemical and biophysical research communications 2006) 3 4 22 60

Products for TRIM21 Gene

Sources for TRIM21 Gene

Content
Loading form....