TRIM21 Gene
protein-coding GIFtS: 64
GCID: GC11M004406
|
|
tripartite motif containing 21(Previous names: Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen...)
(Previous symbol: SSA1)
| |
Aliases
for TRIM21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tripartite Motif Containing 211 2 | | 52 KDa Ro Protein2 3 | | RO521 2 3 5 | | SS-A2 3 | | SSA11 2 3 5 | | RING Finger Protein 812 3 | | RNF811 2 3 | | SSA2 | | Sjogren Syndrome Antigen A1 (52kDa, Ribonucleoprotein Autoantigen SS-A/Ro)1 2 | | E3 Ubiquitin-Protein Ligase TRIM212 | | Tripartite Motif-Containing 211 2 | | Ro(SS-A)3 | | Sjoegren Syndrome Type A Antigen2 3 | | Sicca Syndrome Antigen A2 | | Tripartite Motif-Containing Protein 212 3 | | EC 6.3.2.-3 | | 52 KDa Ribonucleoprotein Autoantigen Ro/SS-A2 3 | | Ro(SS-A)3 |
Export aliases for TRIM21 gene to outside databasesPrevious GC identifers: GC11M004363 GC11M004064 |
Summaries
for TRIM21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TRIM21:
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, aRING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSAribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particlelocalizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndromeand systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but thefull-length nature of only one has been determined. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RO52_HUMAN, P19474Function: E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2.Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination ofUSP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex isshown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by theproteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negativelyregulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates theubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associateddegradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokinegenes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances thedecapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composedof a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and redblood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of theseproteins is their ability to bind HY RNAs.2
Gene Wiki entry for TRIM21
|
Genomic Views
for TRIM21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRIM21 gene promoter:
AML1a SREBP-1c Pax-2 Pax-2a Evi-1 SREBP-1b AREB6 c-Rel SREBP-1a Pax-2b
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIM21
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM21 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.5-p15.3TRIM21 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M004406: view genomic region
(about GC identifiers)
Start:
|
4,406,127 bp from pter |
End:
|
4,414,926 bp from pter |
Size:
|
8,800 bases |
Orientation:
|
minus strand |
|
Proteins
for TRIM21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RO52_HUMAN, P19474 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase TRIM21 Size: 475 amino acids; 54170 Da
Subunit: Interacts (via C-terminus) with IRF8 (via C-terminus) (By similarity). Component of a SCF(SKP2)-like complexcontaining CUL1, SKP1, TRIM21 and SKP2. Interacts with CALR, CUL1, FBXW11, HSPA5, IKBKB, IRF3, SKP1 and VCP. Interactswith SKP2; the interaction with SKP2 does not depend on an intact F-box domain. Interacts (via N-terminus andC-terminus) with DCP2 (via N-terminus and C-terminus)
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Enters the nucleus upon exposure to nitric oxide.Localizes to small dot- or rod-like structures in the cytoplasm, called cytoplasmic bodies (P-body) that are locatedunderneath the plasma membrane and also diffusely in the cytoplasm and are highly motil in cells. Cytoplasmic bodiesare located along the microtubules and do not share the same cytoplasmic bodies with TRIM5. Colocalizes with DCP2 inP-body
1 PDB 3D structure from  and Proteopedia  for TRIM21:2IWG (3D)
Secondary accessions: Q5XPV5 Q96RF8Alternative splicing: 2 isoforms: P19474-1 P19474-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TRIM21: NX_P19474
Post-translational modifications:
Autoubiquitinated; does not lead to its proteasomal degradation. Deubiquitinated by USP4; leading to its stabilization1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P19474
TRIM21 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003132.2
ENSEMBL proteins: ENSP00000434053 ENSP00000254436 ENSP00000444045 Reactome Protein details: P19474
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
TRIM21 for ontologies About GeneDecksing
TRIM21 Antibody Products:
Assay Products for TRIM21: |
Protein
Domains /
Families
for TRIM21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIM21 for domains About GeneDecksing
5/12 InterPro domains/families (see all 12):Graphical View of Domain Structure for InterPro Entry P19474ProtoNet protein and cluster: P19474 4 Blocks protein families: IPB000315 B-box zinc finger signature IPB001841 Zn-finger IPB003879 Butyrophylin C-terminal DUF signature IPB006574 SPRY-associated domain
UniProtKB/Swiss-Prot: RO52_HUMAN, P19474Domain: The coiled-coil is necessary for the cytoplasmic localization. The B30.2/SPRY domain is necessary for thecytoplasmic localization, the interaction with IRF3 and for the IRF3-driven interferon beta promoter activity. TheRING-type zinc finger is necessary for ubiquitination and for the IRF3-driven interferon beta promoter activity.Interacts with SKP2 and CUL1 in a RING finger-independent mannerSimilarity: Belongs to the TRIM/RBCC familySimilarity: Contains 1 B box-type zinc fingerSimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 RING-type zinc finger |
Function
for TRIM21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RO52_HUMAN, P19474Function: E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2.Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination ofUSP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex isshown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by theproteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negativelyregulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates theubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associateddegradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokinegenes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances thedecapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composedof a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and redblood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of theseproteins is their ability to bind HY RNAs.2Induction: Up-regulated by isoform 2 of XBP1Enzyme Number (IUBMB): EC 6.3.2.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM21 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM21
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TRIM21 (NM_003141) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM21 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM21 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM21 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
TRIM21 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for TRIM21:
Animal Models:
7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Trim21):
TRIM21 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TRIM21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Immune System | | | 3 | Systemic lupus erythematosus | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for TRIM21
1 
Kegg Pathway (Kegg details for TRIM21):
UniProtKB/Swiss-Prot: RO52_HUMAN, P19474Pathway: Protein modification; protein ubiquitination
TRIM21 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRIM21
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/614 Interacting proteins for TRIM21 (P194741, 2, 3 ENSP000002544364) via UniProtKB, MINT, STRING, and/or I2D (see all 614)
About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
TRIM21 for ontologies About GeneDecksing
|
Drugs & Compounds
for TRIM21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TRIM21 for compounds About GeneDecksing
 Browse Tocris compounds for TRIM21
5 Novoseek chemical compound relationships for TRIM21 gene About this table
Search CenterWatch for drugs/clinical trials and news about TRIM21 / RO52
|
Transcripts
for TRIM21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRIM21 gene: NM_003141.3 Unigene Cluster for TRIM21: Tripartite motif containing 21 Hs.532357 [show with all ESTs]Unigene Representative Sequence: NM_0031413 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000533692 ENST00000254436(uc001lyy.1) ENST00000543625
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM21 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM21
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRIM21 (NM_003141) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM21 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM21 |
Additional cDNA sequence: AK225564.1 AY742713.1 BC010861.1 M34551.1 M62800.1 5 DOTS entries: DT.213907 DT.100779337 DT.95214115 DT.99966324 DT.102823209 24/97 AceView cDNA sequences (see all 97): BX340999 AW663379 BU616734 BM127233 CA309266 CK906134 AA159361 BU738231 BC010861 BU957579 T56733 BU619381 BM474980 CK906135 AA300987 BM693791 BF593766 BE910692 BG258617 BM974766 BQ009912 AW014509 AA524717 BI758939
GeneLoc Exon Structure
|
Expression
for TRIM21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRIM21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCTGCCTT
About this image
See TRIM21 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIM21
SOURCE GeneReport for Unigene cluster: Hs.532357
UniProtKB/Swiss-Prot: RO52_HUMAN, P19474Tissue specificity: Isoform 1 and isoform 2 are expressed in fetal and adult heart and fetal lung
SABiosciences Custom PCR Arrays for TRIM21
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM21
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIM21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM21 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM21 |
Orthologs
for TRIM21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TRIM21 gene from 2/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
TRIM586 |
-- |
40(a) |
1 → many |
GL343252.1(1250786-1269672) |
zebrafish
(Danio rerio) |
Actinopterygii |
trim476 |
tripartite motif containing 47 |
25(a) |
possible ortholog |
10(26752552-26762609) |
ENSEMBL Gene Tree for TRIM21 (if available)
TreeFam Gene Tree for TRIM21 (if available) |
Paralogs
for TRIM21 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRIM21 gene
- TRIM42 TRIM72 TRIM262 TRIM392 TRIM342 TRIML12 TRIM272 TRIM582
- TRIM682 TRIM102 TRIM152 TRIM602 TRIM222 TRIM172 TRIM52 TRIM62
- TRIM6-TRIM342 TRIM382 TRIM39-RPP212 TRIM112
18/52 SIMAP similar genes for TRIM21 using alignment to 3 protein entries: RO52_HUMAN (see all proteins)
(see all similar genes):ERMAP TRIM68 TRIM5 TRIM41 TRIM58 TRIM6
TRIM39R TRIM6-TRIM34 TRIM27 TRIM34 TRIM39 TRIM11
BT3.3 TRIM38 DKFZp686F23130 DKFZp781D1977 TRIML1 BTNL9
TRIM21 for paralogs About GeneDecksing
|
Genomic Variants
for TRIM21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRIM21 (4406127 - 4414926 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TRIM21
2 CNVs: 2164 3834
Human Gene Mutation Database (HGMD): TRIM21
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM21 |
|
Disorders
/ Diseases
for TRIM21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRIM21 for disorders About GeneDecksing
OMIM gene information: 109092
OMIM disorders: --
20/39  diseases for TRIM21 (see all 39): About MalaCardssjogren's syndrome lupus erythematosus systemic lupus erythematosus heart block
congenital heart block mixed connective tissue disease transient neonatal thrombocytopenia keratoconjunctivitis sicca
connective tissue disease mycobacterial infection cutaneous lupus erythematosus xerophthalmia
esophageal squamous cell carcinoma primary pulmonary hypertension squamous cell carcinoma pulmonary hypertension
sickle cell disease rheumatoid arthritis paraneoplastic syndromes systemic scleroderma
5 diseases from the University of Copenhagen DISEASES database for TRIM21:Congenital heart block Systemic lupus erythematosus Sjogren's syndrome Cutaneous lupus erythematosus
Myositis 10/17 Novoseek disease relationships for TRIM21 gene (see all 17) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| congenital heart block |
87.7 |
13 |
14987746 (3), 16830880 (2), 2031658 (1), 2396870 (1) (see all 7) |
| sjogrens syndrome |
77.2 |
12 |
12410795 (2), 10680747 (1), 12646630 (1), 8871672 (1) (see all 10) |
| lupus erythematosus systemic |
73.1 |
17 |
8310208 (2), 16356190 (1), 18022694 (1), 8714273 (1) (see all 15) |
| lupus erythematosus cutaneous subacute |
67.7 |
2 |
8823371 (1), 10584550 (1) |
| lupus erythematosus |
67.5 |
4 |
10680747 (1), 8823371 (1), 7774062 (1) |
| autoimmune response |
67.2 |
5 |
10587550 (2), 9218821 (1), 8871672 (1) |
| sjogrens syndrome primary |
66.8 |
7 |
11263778 (2), 16095123 (2), 8714273 (1), 12528117 (1) (see all 5) |
| autoimmune diseases |
60.9 |
10 |
10587550 (2), 2031658 (1), 18022694 (1), 10364476 (1) (see all 7) |
| rheumatic diseases |
57.9 |
1 |
15916807 (1) |
| myopathies idiopathic inflammatory |
54.7 |
1 |
9218821 (1) |
Genetic Association Database (GAD): TRIM21
Human Genome Epidemiology (HuGE) Navigator: TRIM21 (4 documents)
Export disorders for TRIM21 gene to outside databases
|
Publications
for TRIM21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRIM21 gene, integrated from 9 sources (see all 161):
(articles sorted by number of sources associating them with TRIM21) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Autoantigen Ro52 is an E3 ubiquitin ligase. (PubMed id 16297862)1, 2, 9 Wada K. and Kamitani T. (2006)
- Ro52 functionally interacts with IgG1 and regulates its quality control via the ERAD system. (PubMed id 18022694)1, 2, 9 Takahata M....Hatakeyama S. (2008)
- Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity. (PubMed id 16316627)1, 2, 9 Wada K....Kamitani T. (2006)
- A novel polymorphism of the SSA1 gene is associated with anti-SS-A/Ro52 autoantibody in Japanese patients with primary Sjogren's syndrome. (PubMed id 16095123)1, 4, 9 Imanishi T....Kumagai S. (2005)
- Polymorphisms of the Ro52 gene associated with anti-Ro 52-kd autoantibodies in patients with primary Sjogren's syndrome. (PubMed id 11263778)1, 4, 9 Nakken B....Bolstad A.I. (2001)
- SSA/Ro52 autoantigen interacts with Dcp2 to enhance its decapping activity. (PubMed id 18361920)1, 2, 9 Yamochi T....Morimoto C. (2008)
- The location of a disease-associated polymorphism and genomic structure of the human 52-kDa Ro/SSA locus (SSA1). (PubMed id 7713506)1, 2, 9 Tsugu H.... Frank M.B. (1994)
- Dynamic movements of Ro52 cytoplasmic bodies along mi crotubules. (PubMed id 20013343)1, 2 Tanaka M....Kamitani T. (2010)
- Ro52-mediated monoubiquitination of IKK{beta} down-re gulates NF-{kappa}B signalling. (PubMed id 19675099)1, 2 Wada K....Kamitani T. (2009)
- The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide. (PubMed id 18845142)1, 2 Espinosa A....Wahren-Herlenius M. (2008)
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External Searches for TRIM21 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing TRIM21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing TRIM21 gene
(According to HUGE)
About This Section
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Specialized Databases showing TRIM21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for TRIM21 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for TRIM21 gene:
Search GeneIP for patents involving TRIM21
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TRIM21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for TRIM21 | | OriGene shRNA RFP for TRIM21 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM21 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM21 | | | OriGene Protein Over-expression Lysate for TRIM21 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRIM21 | | OriGene 3'-UTR Clone for TRIM21 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM21 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM21 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TRIM21 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TRIM21 | | OriGene Custom Protein Services for TRIM21 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIM21 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM21 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM21 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM21 |
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| | | | Search Tocris compounds for TRIM21 |
| |  |  |  |  | | | | | | Recombinant Protein for TRIM21 |
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 | | | TRIM21 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM21 |
|  |  |  | | | | ThermoFisher Antibody for TRIM21 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM21 |
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