Aliases for TRIM2 Gene
External Ids for TRIM2 Gene
Previous GeneCards Identifiers for TRIM2 Gene
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
GeneCards Summary for TRIM2 Gene
TRIM2 (Tripartite Motif Containing 2) is a Protein Coding gene. Diseases associated with TRIM2 include Charcot-Marie-Tooth Disease, Type 2R and Axonal Neuropathy. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Interferon gamma signaling. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is TRIM3.
UniProtKB/Swiss-Prot for TRIM2 Gene
UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.