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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM2 Gene

protein-coding   GIFtS: 53
GCID: GC04P154073

tripartite motif containing 2

(Previous name: tripartite motif-containing 2 )
 Explore 4 diseases affiliated with
TRIM2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRIM2    

Aliases
for TRIM2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tripartite Motif Containing 21 2     RING Finger Protein 862 3
RNF861 2 3     Tripartite Motif Protein 22
Tripartite Motif-Containing 21 2     Tripartite Motif Protein TRIM22
KIAA05171 3     Tripartite Motif-Containing Protein 22
E3 Ubiquitin-Protein Ligase TRIM22 3     EC 6.3.2.-3

External Ids:    HGNC: 159741   Entrez Gene: 233212   Ensembl: ENSG000001096547   OMIM: 6141415   UniProtKB: Q9C0403   

Export aliases for TRIM2 gene to outside databases

Previous GC identifers: GC04P154972 GC04P154462 GC04P154703 GC04P154483 GC04P154345 GC04P149803


Summaries
for TRIM2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TRIM2:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to
cytoplasmic filaments. Its function has not been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TRIM2_HUMAN, Q9C040
Function: UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated
BCL2L11 (By similarity). Plays a neuroprotective function (By similarity). May play a role in neuronal rapid ischemic
tolerance (By similarity)




Genomic Views
for TRIM2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM2 gene promoter:
         MyoD   AP-4   YY1   RORalpha1   NF-Y   Zic3   Pax-4a   CBF(2)   Ik-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRIM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.3   Ensembl cytogenetic band:  4q31.3   HGNC cytogenetic band: 4q31.3

TRIM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P154073:  view genomic region     (about GC identifiers)

Start:
 154,073,494 bp from pter      End:
 154,260,474 bp from pter
Size:
 186,981 bases      Orientation:
 plus strand

Proteins
for TRIM2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TRIM2_HUMAN, Q9C040 (See protein sequence)
Recommended Name: Tripartite motif-containing protein 2  
Size: 744 amino acids; 81530 Da
Subunit: Interacts with myosin V; myosin V may not be a substrate for ubiquitination (By similarity). Interacts with
NEFL (By similarity). Interacts with phosphorylated BCL2L11
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=BAA25443.1; Type=Erroneous initiation;
Secondary accessions: O60272 Q9BSI9 Q9UFZ1

Explore the universe of human proteins at neXtProt for TRIM2: NX_Q9C040

Post-translational modifications:

  • RING-type zinc finger-dependent and UBE2D1-dependent autoubiquitination (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9C040

    • TRIM2 Protein expression data from MOPED and PaxDb:    About this image 
    TRIM2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001123539.1  NP_056086.2  

    ENSEMBL proteins: 
     ENSP00000400879   ENSP00000415812   ENSP00000339659   ENSP00000400375  

    Human Recombinant Protein Products for TRIM2: 
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    OriGene Protein Over-expression Lysate (see all 2): TRIM2
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    Novus Biologicals TRIM2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TRIM2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA11331580

    TRIM2 for ontologies           About GeneDecksing



    TRIM2 Antibody Products: 
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    Uscn ELISAs and CLIAs for TRIM2

    Protein Domains /
    Families
    for TRIM2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRIM2 for domains           About GeneDecksing

    5/12 InterPro domains/families (see all 12):
     IPR003649 Bbox_C
     IPR017907 Znf_RING_CS
     IPR001298 Filamin
     IPR001841 Znf_RING
     IPR014756 Ig_E-set

    Graphical View of Domain Structure for InterPro Entry Q9C040

    ProtoNet protein and cluster: Q9C040

    5 Blocks protein families:
    IPB000315 B-box zinc finger signature
    IPB001258 NHL repeat
    IPB001298 Filamin/ABP280 repeat
    IPB001841 Zn-finger
    IPB003649 B-box


    UniProtKB/Swiss-Prot: TRIM2_HUMAN, Q9C040
    Domain: The interaction with myosin V is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain
    containing six blades (By similarity)
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 filamin repeat
    Similarity: Contains 6 NHL repeats
    Similarity: Contains 1 RING-type zinc finger


    Function
    for TRIM2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRIM2_HUMAN, Q9C040
    Function: UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated
    BCL2L11 (By similarity). Plays a neuroprotective function (By similarity). May play a role in neuronal rapid ischemic
    tolerance (By similarity)

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity ISS--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding NAS11331580
         
    TRIM2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TRIM2:
     Decreased cilium length after   Increased cell death HMECs cel  Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Trim2):
     behavior/neurological  nervous system  vision/eye 

    TRIM2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TRIM2 

    miRNA
    Products:            		miRTarBase miRNAs that target TRIM2:
    hsa-mir-1 (MIRT002748)

    OriGene 3'-UTR Clone (see all 2): TRIM2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM2
    8/99 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM2 (see all 99):
    hsa-miR-520e hsa-miR-4254 hsa-miR-15a hsa-miR-485-3p hsa-miR-938 hsa-miR-200a hsa-miR-4315 hsa-miR-759
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM2 (see all 7)
    OriGene shRNA RFP: TRIM2
    OriGene siRNA: TRIM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM2
    Sirion Biotech Custom design and validation of potent shRNA sequences against TRIM2 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of TRIM2 
    Sirion Biotech Customized adenovirus for potent knockdown of TRIM2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM2 (see all 5)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM2 

    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM2


    Pathways & Interactions
    for TRIM2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: TRIM2_HUMAN, Q9C040
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/28 Interacting proteins for TRIM2 (Q9C0403 ENSP000003396594) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIRPAP783243, ENSP000003483074I2D: score=3 STRING: ENSP00000348307
    UBE2D2P628373, ENSP000003817174I2D: score=3 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ----
    GO:0016567protein ubiquitination ----
    GO:0043523regulation of neuron apoptotic process ISS--
    GO:0043526neuroprotection ----

    TRIM2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRIM2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM2
    Search CenterWatch for drugs/clinical trials and news about TRIM2 

    Transcripts
    for TRIM2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRIM2 gene (2 alternative transcripts): 
    NM_001130067.1  NM_015271.3  

    Unigene Cluster for TRIM2:

    Tripartite motif containing 2
    Hs.435711  [show with all ESTs]
    Unigene Representative Sequence: NM_001130067
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491446 ENST00000441616 ENST00000437508 ENST00000494872 ENST00000496978
    ENST00000479711 ENST00000338700(uc003ing.2 uc003inh.2) ENST00000502281
    ENST00000482578(uc003ini.1) ENST00000433687 ENST00000460908

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): TRIM2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM2
    8/99 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM2 (see all 99):
    hsa-miR-520e hsa-miR-4254 hsa-miR-15a hsa-miR-485-3p hsa-miR-938 hsa-miR-200a hsa-miR-4315 hsa-miR-759
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM2 (see all 7)
    OriGene shRNA RFP: TRIM2
    OriGene siRNA: TRIM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM2
    Sirion Biotech Custom design and validation of potent shRNA sequences against TRIM2 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM2 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): TRIM2 (NM_033228)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM2

    Additional cDNA sequence: 

    AB011089.1 AF220018.1 AK000179.1 AK308731.1 AL110178.1 AL110234.1 BC005016.1 BC011052.1 
    BC019242.1 BC025417.1 

    17 DOTS entries:

    DT.118104  DT.95185394  DT.91755327  DT.121267799  DT.75110802  DT.86838963  DT.95295331  DT.100668209 
    DT.91755329  DT.91932916  DT.100743396  DT.121267792  DT.75113951  DT.86843158  DT.99958199  DT.75181154 
    DT.95185419 

    24/230 AceView cDNA sequences (see all 230):

    AA666302 BQ432267 AI870300 BQ962056 AW294359 F12269 BI438831 BM977800 
    AI298925 Z39362 Z43290 BI439604 BF002918 AA338890 AI199273 BG403323 
    BM713373 AA626228 BM980919 AK000179 BE890042 AW961041 BQ925390 F09895 

    GeneLoc Exon Structure


    Expression
    for TRIM2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACAAAATCT
    TRIM2 Expression
    About this image

    TRIM2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeHindgutHindgut Endoderm CellsEndoderm
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    EyeLensEye
    EyeRetinaEye
    Gut TubeHindgutGut Tube
    Gut TubeMidgutGut Tube
    KidneyMetanephrosKidney
    LungTracheaLung
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TRIM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM2

    SOURCE GeneReport for Unigene cluster: Hs.435711
        SABiosciences Expression via Pathway-Focused PCR Array including TRIM2: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM2

    Orthologs
    for TRIM2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TRIM2 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Trim21 , 5 tripartite motif-containing 21, 5 90.95(n)1
    99.19(a)1    		   3 (37.48 cM)5
    808901  NM_030706.21  NP_109631.11 
     841604395 
    chicken
    (Gallus gallus)    		 Aves TRIM21 tripartite motif containing 2 84.45(n)
    96.64(a)    		   100857562  XM_003641149.1  XP_003641197.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TRIM26
    		 --
    		 96(a)
    		 1 ↔ 1
    		 5(131155338-131185062)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CD327130.12   -- 78(n)    CD327130.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii trim2a1 tripartite motif-containing 2a 74.25(n)
    80.22(a)    		   100003782  NM_001014371.1  NP_001014393.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta brat3 oogenesis 37(a)   37C6   --
    worm
    (Caenorhabditis elegans)    		 Secernentea ncl-13 xnf7 26(a)   III(7803266-7808096)   --


    ENSEMBL Gene Tree for TRIM2 (if available)
    TreeFam Gene Tree for TRIM2 (if available) 

    Paralogs
    for TRIM2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM2 gene
    TRIM32  TRIM712  NHLRC12  TRIM452  TRIM562  TRIM322  
    7 SIMAP similar genes for TRIM2 using alignment to 4 protein entries:     TRIM2_HUMAN (see all proteins):
    TRIM3    TRIM41    TRIM67    SH3RF3    SH3RF1    TRIM71
    TRIM39

    TRIM2 for paralogs           About GeneDecksing



    Genomic Variants
    for TRIM2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3247 NCBI SNPs in TRIM2 are shown (see all 3247)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 4 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1463956811,2
    		--154072350(+) TATACA/CATCTT 1 -- us2k10--------
    rs1137815951,2
    		C--154072570(+) AACCCC/TATCGC 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1919498901,2
    		--154072673(+) GGAGGC/TGGAGG 1 -- us2k10--------
    rs117287661,2
    		C,F,A,H--154072719(+) cctggG/Tcaata 1 -- us2k16Minor allele frequency- T:0.26NA 132
    rs1430560181,2
    		--154072812(+) GTTTAA/GTAAAT 1 -- us2k10--------
    rs1461948031,2
    		--154072823(+) ATGCAG/TAGTCT 1 -- us2k10--------
    rs76996561,2
    		C,F,A,H--154072853(+) CTCCAC/TAGAAA 1 -- us2k126Minor allele frequency- N:0.00NS EA NA CSA WA 2559
    rs1844164551,2
    		--154073133(+) AATTCA/TTTCTA 1 -- us2k10--------
    rs1390202171,2
    		--154073175(+) GCGAGC/TGACGC 1 -- us2k10--------
    rs126490321,2
    		H--154073300(+) ATCTGG/TGATTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRIM2 (154073494 - 154260474 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for TRIM2
         4 CNVs: 63989 98926 92473 92470
         4 Indels: 46537 60498 92474 80529

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    Disorders / Diseases
    for TRIM2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRIM2 for disorders           About GeneDecksing

    OMIM gene information: 614141    OMIM disorders: --

    4 diseases for TRIM2:    About MalaCards
    arteriovenous malformation    multiple sclerosis    schizophrenia    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: TRIM2 (1 document)

    Export disorders for TRIM2 gene to outside databases

    Publications
    for TRIM2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM2 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with TRIM2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2, 3 Reymond A.... Ballabio A. (2001)
    2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (1998)
    3. Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. (PubMed id 21478148)1, 2 Thompson S.... Meller R. (2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    6. Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-b. (PubMed id 21720722)1 Schonrock N....Gotz J. (2012)
    7. Functional interactions between ubiquitin E2 enzymes a nd TRIM proteins. (PubMed id 21143188)1 Napolitano L.M....Meroni G. (2011)
    8. Genome-wide association study of severity in multiple sclerosis. (PubMed id 21654844)1  ....De Jager P.L. (2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    10. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)

    External Searches for TRIM2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TRIM2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23321 HGNC: 15974 AceView: TRIM2 Ensembl:ENSG00000109654 euGenes: HUgn23321
    ECgene: TRIM2 H-InvDB: TRIM2

    Other Databases showing TRIM2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0517

    Specialized Databases showing TRIM2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TRIM2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TRIM2 gene:
    Search GeneIP for patents involving TRIM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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