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Aliases for TRIM2 Gene

Aliases for TRIM2 Gene

  • Tripartite Motif Containing 2 2 3 5
  • E3 Ubiquitin-Protein Ligase TRIM2 3 4
  • RING Finger Protein 86 3 4
  • RNF86 3 4
  • Tripartite Motif Protein TRIM2 3
  • Tripartite Motif-Containing 2 2
  • EC 6.3.2.- 4
  • KIAA0517 4
  • CMT2R 3

External Ids for TRIM2 Gene

Previous GeneCards Identifiers for TRIM2 Gene

  • GC04P154972
  • GC04P154462
  • GC04P154703
  • GC04P154483
  • GC04P154345
  • GC04P154073
  • GC04P149803

Summaries for TRIM2 Gene

Entrez Gene Summary for TRIM2 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

GeneCards Summary for TRIM2 Gene

TRIM2 (Tripartite Motif Containing 2) is a Protein Coding gene. Diseases associated with TRIM2 include Charcot-Marie-Tooth Disease, Type 2R and Axonal Neuropathy. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is NHLRC4.

UniProtKB/Swiss-Prot for TRIM2 Gene

  • UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM2 Gene

Genomics for TRIM2 Gene

Regulatory Elements for TRIM2 Gene

Enhancers for TRIM2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM2 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM2 Gene

153,152,342 bp from pter
153,339,322 bp from pter
186,981 bases
Plus strand

Genomic View for TRIM2 Gene

Genes around TRIM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM2 Gene

Proteins for TRIM2 Gene

  • Protein details for TRIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • D3DP09
    • O60272
    • Q9BSI9
    • Q9UFZ1

    Protein attributes for TRIM2 Gene

    744 amino acids
    Molecular mass:
    81530 Da
    Quaternary structure:
    • Interacts with myosin V; myosin V may not be a substrate for ubiquitination (By similarity). Interacts with NEFL (By similarity). Interacts with phosphorylated BCL2L11.
    • Sequence=AAG53472.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA25443.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM2 Gene


neXtProt entry for TRIM2 Gene

Proteomics data for TRIM2 Gene at MOPED

Post-translational modifications for TRIM2 Gene

  • RING-type zinc finger-dependent and UBE2D1-dependent autoubiquitination.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM2 Gene

Domains & Families for TRIM2 Gene

Gene Families for TRIM2 Gene

Suggested Antigen Peptide Sequences for TRIM2 Gene

Graphical View of Domain Structure for InterPro Entry



  • The interaction with myosin V is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • The interaction with myosin V is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 filamin repeat.
  • Contains 6 NHL repeats.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM2: view

Function for TRIM2 Gene

Molecular function for TRIM2 Gene

UniProtKB/Swiss-Prot Function:
UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.

Enzyme Numbers (IUBMB) for TRIM2 Gene

Gene Ontology (GO) - Molecular Function for TRIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0005515 protein binding IEA,IPI 21478148
GO:0008270 zinc ion binding IEA,NAS 11331580
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRIM2: view
genes like me logo Genes that share phenotypes with TRIM2: view

Human Phenotype Ontology for TRIM2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM2 Gene

Localization for TRIM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM2 Gene


Subcellular locations from

Jensen Localization Image for TRIM2 Gene COMPARTMENTS Subcellular localization image for TRIM2 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for TRIM2 Gene

Pathways & Interactions for TRIM2 Gene

genes like me logo Genes that share pathways with TRIM2: view

Pathways by source for TRIM2 Gene

UniProtKB/Swiss-Prot Q9C040-TRIM2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM2 Gene


No data available for SIGNOR curated interactions for TRIM2 Gene

Drugs & Compounds for TRIM2 Gene

No Compound Related Data Available

Transcripts for TRIM2 Gene

Unigene Clusters for TRIM2 Gene

Tripartite motif containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM2 Gene

No ASD Table

Relevant External Links for TRIM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM2 Gene

mRNA expression in normal human tissues for TRIM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.0).

Protein differential expression in normal tissues from HIPED for TRIM2 Gene

This gene is overexpressed in Fetal Brain (21.8), Brain (15.8), Frontal cortex (11.6), and Spinal cord (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM2 Gene

SOURCE GeneReport for Unigene cluster for TRIM2 Gene Hs.435711

genes like me logo Genes that share expression patterns with TRIM2: view

Protein tissue co-expression partners for TRIM2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TRIM2 Gene

Orthologs for TRIM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIM2 35
  • 90.91 (n)
  • 98.92 (a)
TRIM2 36
  • 99 (a)
(Mus musculus)
Mammalia Trim2 35
  • 90.95 (n)
  • 99.19 (a)
Trim2 16
Trim2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Trim2 35
  • 90.28 (n)
  • 98.79 (a)
(Canis familiaris)
Mammalia -- 36
  • 98 (a)
(Monodelphis domestica)
Mammalia TRIM2 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia TRIM2 36
  • 77 (a)
(Pan troglodytes)
Mammalia TRIM2 36
  • 98 (a)
(Gallus gallus)
Aves TRIM2 35
  • 84.45 (n)
  • 96.64 (a)
TRIM2 36
  • 97 (a)
(Anolis carolinensis)
Reptilia TRIM2 36
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trim2 35
  • 78.67 (n)
  • 92.47 (a)
(Danio rerio)
Actinopterygii trim2a 35
  • 74.25 (n)
  • 80.22 (a)
trim2a 36
  • 80 (a)
trim2b 36
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta brat 37
  • 37 (a)
brat 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea ncl-1 37
  • 26 (a)
ncl-1 36
  • 18 (a)
nhl-3 36
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for TRIM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM2 Gene

Gene Tree for TRIM2 (if available)
Gene Tree for TRIM2 (if available)

Paralogs for TRIM2 Gene

Paralogs for TRIM2 Gene

(7) SIMAP similar genes for TRIM2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM2: view

Variants for TRIM2 Gene

Sequence variations from dbSNP and Humsavar for TRIM2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_070874 Charcot-Marie-Tooth disease 2R (CMT2R)
rs893803 -- 153,303,137(-) TTTGT(A/G)GTCAA intron-variant
rs893804 -- 153,303,128(-) AAAGG(C/T)ATGGA intron-variant
rs893805 -- 153,295,558(+) GGGAC(A/G/T)ATCTT reference, synonymous-codon
rs1138108 -- 153,278,705(+) gaggt(A/G)ggagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM2 Gene

Variant ID Type Subtype PubMed ID
nsv4556 CNV Insertion 18451855
esv2728552 CNV Deletion 23290073
esv269045 CNV Insertion 20981092
esv273567 CNV Insertion 20981092
esv2662968 CNV Deletion 23128226
esv28591 CNV Loss 19812545
nsv514259 CNV Loss 21397061
esv2567648 CNV Deletion 19546169
esv2119302 CNV Deletion 18987734
esv8682 CNV Gain 19470904
nsv509939 CNV Loss 20534489

Variation tolerance for TRIM2 Gene

Residual Variation Intolerance Score: 3.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM2 Gene

Disorders for TRIM2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TRIM2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, type 2r
  • charcot-marie-tooth disease type 2r
axonal neuropathy
amyotrophic lateral sclerosis type 5
  • als5
charcot-marie-tooth disease
  • dejerine-sottas disease
- elite association - COSMIC cancer census association via MalaCards
Search TRIM2 in MalaCards View complete list of genes associated with diseases


  • Charcot-Marie-Tooth disease 2R (CMT2R) [MIM:615490]: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. {ECO:0000269 PubMed:23562820}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TRIM2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRIM2: view

No data available for Genatlas for TRIM2 Gene

Publications for TRIM2 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3
  3. Exome sequencing reveals homozygous TRIM2 mutation in a patient with early onset CMT and bilateral vocal cord paralysis. (PMID: 25893792) Pehlivan D. … Harel T. (Hum. Genet. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for TRIM2 Gene

Sources for TRIM2 Gene