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Aliases for TRIM17 Gene

Aliases for TRIM17 Gene

  • Tripartite Motif Containing 17 2 3 5
  • Testis RING Finger Protein 2 3 4
  • Ring Finger Protein 16 2 3 4
  • Tripartite Motif-Containing Protein 17 3 4
  • RING Finger Protein Terf 2 3
  • RNF16 3 4
  • Terf 3 4
  • RBCC 3 4
  • E3 Ubiquitin-Protein Ligase TRIM17 3
  • Tripartite Motif-Containing 17 2
  • EC 6.3.2.- 4

External Ids for TRIM17 Gene

Previous HGNC Symbols for TRIM17 Gene

  • RNF16

Previous GeneCards Identifiers for TRIM17 Gene

  • GC01M227093
  • GC01M224334
  • GC01M224981
  • GC01M225570
  • GC01M224902
  • GC01M226662
  • GC01M228595
  • GC01M199112

Summaries for TRIM17 Gene

Entrez Gene Summary for TRIM17 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein is expressed almost exclusively in the testis, but its function is unknown. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM17 Gene

TRIM17 (Tripartite Motif Containing 17) is a Protein Coding gene. Diseases associated with TRIM17 include Opitz Gbbb Syndrome, Type Ii and Branchiootic Syndrome. Among its related pathways are Interferon gamma signaling and Immune System. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is MIR6742.

UniProtKB/Swiss-Prot for TRIM17 Gene

  • May function as a ubiquitin E3 ligase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM17 Gene

Genomics for TRIM17 Gene

Regulatory Elements for TRIM17 Gene

Enhancers for TRIM17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F228445 1.3 FANTOM5 Ensembl ENCODE 16.9 -29.2 -29206 1.1 USF1 BHLHE40 USF2 MAX BMI1 ZBTB7A ZBTB40 SREBF1 RAD51 ZBTB33 TRIM17 OBSCN TRIM11 MIR6742 ENSG00000231563 C1orf145 WNT3A GJC2 HIST3H2A RPL23AP15
GH01F227437 1.1 Ensembl ENCODE 13.1 +979.0 978977 1.0 YBX3 PKNOX1 CBX3 ARNT ZNF2 RAD21 RFX5 CHAMP1 YY1 GATA2 CDC42BPA IBA57-AS1 ENSG00000269890 TRIM17 ENSG00000231563 CICP26 WNT9A BTF3P9 ENSG00000237193
GH01F228366 1.3 Ensembl ENCODE 6 +48.1 48125 3.7 HDGF ATF1 PKNOX1 ARNT ARID4B ZNF48 GLIS2 ELK1 GATA2 KDM4B C1orf35 JMJD4 OBSCN TRIM17 LOC101927401 ENSG00000270104
GH01F228417 0.7 ENCODE 9.4 -0.9 -946 1.3 DDX20 ZNF175 PTRF RELA IRF9 STAT1 ZNF687 ZNF740 NR4A1 GTF2A2 TRIM17 GC01M228428
GH01F228392 0.9 ENCODE 5.7 +24.3 24331 0.5 ZNF76 GLIS2 FOS EGR2 JUNB ZEB2 ZFP69B SMARCA4 GLIS1 IKZF1 RPL23AP15 HIST3H2A HIST3H2BB C1orf145 OBSCN TRIM17 ENSG00000270094 ENSG00000270104
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM17 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001755533 282 801 CTCF MBD1 ZBTB33

Genomic Location for TRIM17 Gene

228,407,935 bp from pter
228,416,882 bp from pter
8,948 bases
Minus strand

Genomic View for TRIM17 Gene

Genes around TRIM17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM17 Gene

Proteins for TRIM17 Gene

  • Protein details for TRIM17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase TRIM17
    Protein Accession:
    Secondary Accessions:
    • B4DVJ2
    • Q5VST8

    Protein attributes for TRIM17 Gene

    477 amino acids
    Molecular mass:
    54418 Da
    Quaternary structure:
    • Interacts (via coiled coil) with TRIM44 (via coiled coil).

    Alternative splice isoforms for TRIM17 Gene


neXtProt entry for TRIM17 Gene

Post-translational modifications for TRIM17 Gene

No data available for DME Specific Peptides for TRIM17 Gene

Domains & Families for TRIM17 Gene

Gene Families for TRIM17 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM17: view

Function for TRIM17 Gene

Molecular function for TRIM17 Gene

UniProtKB/Swiss-Prot Function:
May function as a ubiquitin E3 ligase.

Enzyme Numbers (IUBMB) for TRIM17 Gene

Gene Ontology (GO) - Molecular Function for TRIM17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 19358823
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0030674 protein binding, bridging IPI 25127057
genes like me logo Genes that share ontologies with TRIM17: view
genes like me logo Genes that share phenotypes with TRIM17: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM17 Gene

Localization for TRIM17 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM17 gene
Compartment Confidence
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TRIM17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM17: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM17 Gene

Pathways & Interactions for TRIM17 Gene

genes like me logo Genes that share pathways with TRIM17: view

Pathways by source for TRIM17 Gene

UniProtKB/Swiss-Prot Q9Y577-TRI17_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA,IDA 25127057
GO:0016567 protein ubiquitination IEA --
GO:0032880 regulation of protein localization IMP 25127057
GO:0051865 protein autoubiquitination IDA 19358823
genes like me logo Genes that share ontologies with TRIM17: view

No data available for SIGNOR curated interactions for TRIM17 Gene

Transcripts for TRIM17 Gene

Unigene Clusters for TRIM17 Gene

Tripartite motif containing 17:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM17 Gene

No ASD Table

Relevant External Links for TRIM17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM17 Gene

This gene is overexpressed in Brain - Cerebellum (x7.5), Brain - Cerebellar Hemisphere (x6.7), Testis (x5.9), and Brain - Nucleus accumbens (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for TRIM17 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM17 Gene

Protein tissue co-expression partners for TRIM17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM17 Gene:


SOURCE GeneReport for Unigene cluster for TRIM17 Gene:


mRNA Expression by UniProt/SwissProt for TRIM17 Gene:

Tissue specificity: Almost exclusively in the testis.
genes like me logo Genes that share expression patterns with TRIM17: view

Primer Products

Orthologs for TRIM17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM17 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM17 34 35
  • 98.74 (n)
(Canis familiaris)
Mammalia TRIM17 34 35
  • 79.51 (n)
(Mus musculus)
Mammalia Trim17 34 16 35
  • 79.39 (n)
(Bos Taurus)
Mammalia TRIM17 34 35
  • 79.23 (n)
(Rattus norvegicus)
Mammalia Trim17 34
  • 78.62 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 34 (a)
-- 35
  • 32 (a)
-- 35
  • 32 (a)
-- 35
  • 30 (a)
-- 35
  • 29 (a)
Species where no ortholog for TRIM17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM17 Gene

Gene Tree for TRIM17 (if available)
Gene Tree for TRIM17 (if available)

Paralogs for TRIM17 Gene

Variants for TRIM17 Gene

Sequence variations from dbSNP and Humsavar for TRIM17 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10799476 -- 228,415,328(+) CCTCT(A/C)CTCTC intron-variant, utr-variant-5-prime
rs111277250 -- 228,418,523(+) TGAAC(A/C)CAGAA upstream-variant-2KB
rs111313864 -- 228,407,158(+) AGGAG(C/G)GATGG downstream-variant-500B, upstream-variant-2KB
rs111561181 -- 228,412,623(+) AAAAA(A/T)GCTGG intron-variant
rs111735128 -- 228,409,107(+) GCTAG(G/T)GGGTA intron-variant, reference, synonymous-codon, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRIM17 Gene

Variant ID Type Subtype PubMed ID
nsv952141 CNV deletion 24416366
nsv827019 CNV loss 20364138
nsv826908 CNV gain 20364138
nsv549296 CNV gain 21841781
nsv549295 CNV loss 21841781
nsv523935 CNV loss 19592680
nsv517545 CNV loss 19592680
nsv508697 CNV deletion 20534489
nsv470780 CNV loss 18288195
nsv1068577 CNV deletion 25765185
nsv1013500 CNV gain 25217958
esv32853 CNV gain 17666407

Variation tolerance for TRIM17 Gene

Residual Variation Intolerance Score: 32.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM17 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM17 Gene

Disorders for TRIM17 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRIM17 Gene - From: DISEASES

Disorder Aliases PubMed IDs
opitz gbbb syndrome, type ii
  • opitz-gbbb syndrome
branchiootic syndrome
  • branchiootic syndrome 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIM17

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRIM17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM17 Gene

Publications for TRIM17 Gene

  1. Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis. (PMID: 9792805) Ogawa S. … Inoue S. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 22 64
  2. Chromosome mapping of RNF16 and rnf16, human, mouse and rat genes coding for testis RING finger protein (terf), a member of the RING finger family. (PMID: 10894938) Ogawa S. … Inoue S. (Cytogenet. Cell Genet. 2000) 2 3 22 64
  3. TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase. (PMID: 19358823) Urano T. … Inoue S. (Biochem. Biophys. Res. Commun. 2009) 3 4 64
  4. Candidate-gene testing for orphan limb-girdle muscular dystrophies. (PMID: 19472918) Aurino S. … Nigro V. (Acta Myol 2008) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for TRIM17 Gene

Sources for TRIM17 Gene

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