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Aliases for TRIM17 Gene

Aliases for TRIM17 Gene

  • Tripartite Motif Containing 17 2 3 5
  • Testis RING Finger Protein 2 3 4
  • Ring Finger Protein 16 2 3 4
  • RING-Type E3 Ubiquitin Transferase TRIM17 3 4
  • Tripartite Motif-Containing Protein 17 3 4
  • RING Finger Protein Terf 2 3
  • RNF16 3 4
  • Terf 3 4
  • RBCC 3 4
  • E3 Ubiquitin-Protein Ligase TRIM17 3
  • Tripartite Motif-Containing 17 2
  • EC 2.3.2.27 4

External Ids for TRIM17 Gene

Previous HGNC Symbols for TRIM17 Gene

  • RNF16

Previous GeneCards Identifiers for TRIM17 Gene

  • GC01M227093
  • GC01M224334
  • GC01M224981
  • GC01M225570
  • GC01M224902
  • GC01M226662
  • GC01M228595
  • GC01M199112

Summaries for TRIM17 Gene

Entrez Gene Summary for TRIM17 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein is expressed almost exclusively in the testis, but its function is unknown. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM17 Gene

TRIM17 (Tripartite Motif Containing 17) is a Protein Coding gene. Diseases associated with TRIM17 include Opitz-Gbbb Syndrome and Branchiootic Syndrome. Among its related pathways are Interferon gamma signaling and Cytokine Signaling in Immune system. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is TRIM11.

UniProtKB/Swiss-Prot for TRIM17 Gene

  • May function as a ubiquitin E3 ligase.

Additional gene information for TRIM17 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM17 Gene

Genomics for TRIM17 Gene

Regulatory Elements for TRIM17 Gene

Enhancers for TRIM17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H228445 1.3 FANTOM5 Ensembl ENCODE 17 -29.2 -29206 1 MXI1 NR2F1 MAX USF2 BMI1 MNT ZBTB40 SREBF1 POLR2A EGR1 TRIM17 OBSCN TRIM11 ENSG00000231563 OBSCN-AS1 WNT3A GJC2 HIST3H2A RPL23AP15 HIST3H3
GH01H228366 1.5 Ensembl ENCODE dbSUPER 6 +48.1 48126 3 HDGF PKNOX1 ATF1 ARNT ARID4B TCF12 GLIS2 GATA2 ELK1 ATF7 OBSCN TRIM17 LOC101927401 ENSG00000270104
GH01H228417 0.7 ENCODE 9.4 -0.9 -946 1 ZNF175 RELA IRF9 ZNF687 STAT1 ZNF740 CAVIN1 E2F5 NR4A1 GTF2A2 TRIM17 GC01M228428
GH01H228392 0.9 ENCODE 5.7 +24.3 24331 0 ZNF76 GLIS2 EGR1 FOS ATF7 EGR2 ZEB2 ZNF592 ZFP69B SMARCA4 RPL23AP15 HIST3H2A HIST3H2BB OBSCN-AS1 OBSCN TRIM17 ENSG00000270094 ENSG00000270104
GH01H228393 0.7 ENCODE 5.7 +23.0 23046 1 CTCF ZNF362 CEBPB ZFP37 ZBTB8A ZIC2 RAD21 FOSL1 POLR2A ZNF341 RPL23AP15 HIST3H2BB HIST3H2A HIST3H3 OBSCN-AS1 OBSCN TRIM17 ENSG00000270094 ENSG00000270104
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM17 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000021302 182 201 CTCF MBD1 EZH2

Genomic Location for TRIM17 Gene

Chromosome:
1
Start:
228,407,935 bp from pter
End:
228,416,882 bp from pter
Size:
8,948 bases
Orientation:
Minus strand

Genomic View for TRIM17 Gene

Genes around TRIM17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM17 Gene

Proteins for TRIM17 Gene

  • Protein details for TRIM17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y577-TRI17_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM17
    Protein Accession:
    Q9Y577
    Secondary Accessions:
    • B4DVJ2
    • Q5VST8

    Protein attributes for TRIM17 Gene

    Size:
    477 amino acids
    Molecular mass:
    54418 Da
    Quaternary structure:
    • Interacts (via coiled coil) with TRIM44 (via coiled coil).

    Alternative splice isoforms for TRIM17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM17 Gene

Post-translational modifications for TRIM17 Gene

No data available for DME Specific Peptides for TRIM17 Gene

Domains & Families for TRIM17 Gene

Gene Families for TRIM17 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y577

UniProtKB/Swiss-Prot:

TRI17_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM17: view

Function for TRIM17 Gene

Molecular function for TRIM17 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
May function as a ubiquitin E3 ligase.

Enzyme Numbers (IUBMB) for TRIM17 Gene

Gene Ontology (GO) - Molecular Function for TRIM17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 19358823
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0030674 protein binding, bridging IPI 25127057
genes like me logo Genes that share ontologies with TRIM17: view
genes like me logo Genes that share phenotypes with TRIM17: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TRIM17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM17 Gene

Localization for TRIM17 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM17 gene
Compartment Confidence
nucleus 3
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRIM17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM17: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM17 Gene

Pathways & Interactions for TRIM17 Gene

genes like me logo Genes that share pathways with TRIM17: view

Pathways by source for TRIM17 Gene

UniProtKB/Swiss-Prot Q9Y577-TRI17_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA,IDA 25127057
GO:0016567 protein ubiquitination IEA --
GO:0032880 regulation of protein localization IMP 25127057
GO:0051865 protein autoubiquitination IDA 19358823
genes like me logo Genes that share ontologies with TRIM17: view

No data available for SIGNOR curated interactions for TRIM17 Gene

Drugs & Compounds for TRIM17 Gene

No Compound Related Data Available

Transcripts for TRIM17 Gene

Unigene Clusters for TRIM17 Gene

Tripartite motif containing 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TRIM17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM17 Gene

No ASD Table

Relevant External Links for TRIM17 Gene

GeneLoc Exon Structure for
TRIM17
ECgene alternative splicing isoforms for
TRIM17

Expression for TRIM17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM17 Gene

This gene is overexpressed in Brain - Cerebellum (x7.5), Brain - Cerebellar Hemisphere (x6.7), Testis (x5.9), and Brain - Nucleus accumbens (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for TRIM17 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM17 Gene



Protein tissue co-expression partners for TRIM17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM17 Gene:

TRIM17

SOURCE GeneReport for Unigene cluster for TRIM17 Gene:

Hs.121748

mRNA Expression by UniProt/SwissProt for TRIM17 Gene:

Q9Y577-TRI17_HUMAN
Tissue specificity: Almost exclusively in the testis.

Evidence on tissue expression from TISSUES for TRIM17 Gene

  • Nervous system(4.6)
  • Spleen(4.1)
genes like me logo Genes that share expression patterns with TRIM17: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM17 Gene

Orthologs for TRIM17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM17 33 34
  • 98.74 (n)
dog
(Canis familiaris)
Mammalia TRIM17 34 33
  • 79.51 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Trim17 33 16 34
  • 79.39 (n)
cow
(Bos Taurus)
Mammalia TRIM17 34 33
  • 79.23 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim17 33
  • 78.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 34 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
Species where no ortholog for TRIM17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM17 Gene

ENSEMBL:
Gene Tree for TRIM17 (if available)
TreeFam:
Gene Tree for TRIM17 (if available)

Paralogs for TRIM17 Gene

Variants for TRIM17 Gene

Sequence variations from dbSNP and Humsavar for TRIM17 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000351108 -- 228,412,539(+) GAAGA(C/T)AGTTT intron-variant
rs1000457459 -- 228,411,845(+) CCAGG(C/T)TGGGG intron-variant
rs1000890667 -- 228,416,903(+) GGGAG(A/G)AGTCT upstream-variant-2KB
rs1001100528 -- 228,417,410(+) AGGTG(A/G)TTTTG upstream-variant-2KB
rs1001595743 -- 228,414,446(+) ATCAT(A/G)CAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM17 Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV gain 17666407
nsv1013500 CNV gain 25217958
nsv1068577 CNV deletion 25765185
nsv470780 CNV loss 18288195
nsv508697 CNV deletion 20534489
nsv517545 CNV loss 19592680
nsv523935 CNV loss 19592680
nsv549295 CNV loss 21841781
nsv549296 CNV gain 21841781
nsv826908 CNV gain 20364138
nsv827019 CNV loss 20364138
nsv952141 CNV deletion 24416366

Variation tolerance for TRIM17 Gene

Residual Variation Intolerance Score: 32.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM17 Gene

Human Gene Mutation Database (HGMD)
TRIM17
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM17 Gene

Disorders for TRIM17 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRIM17 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
opitz-gbbb syndrome
  • opitz g/bbb syndrome
branchiootic syndrome
  • branchiootic syndrome 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIM17

Genetic Association Database (GAD)
TRIM17
Human Genome Epidemiology (HuGE) Navigator
TRIM17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM17
genes like me logo Genes that share disorders with TRIM17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM17 Gene

Publications for TRIM17 Gene

  1. Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis. (PMID: 9792805) Ogawa S … Inoue S (Biochemical and biophysical research communications 1998) 2 3 4 22 60
  2. Chromosome mapping of RNF16 and rnf16, human, mouse and rat genes coding for testis RING finger protein (terf), a member of the RING finger family. (PMID: 10894938) Ogawa S … Inoue S (Cytogenetics and cell genetics 2000) 2 3 22 60
  3. TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase. (PMID: 19358823) Urano T … Inoue S (Biochemical and biophysical research communications 2009) 3 4 60
  4. Candidate-gene testing for orphan limb-girdle muscular dystrophies. (PMID: 19472918) Aurino S … Nigro V (Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology 2008) 3 45 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for TRIM17 Gene

Sources for TRIM17 Gene

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