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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM17 Gene

protein-coding   GIFtS: 51
GCID: GC01M228595

tripartite motif containing 17

(Previous name: tripartite motif-containing 17 )
(Previous symbol: RNF16)
 Explore 1 disease affiliated with
TRIM17 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRIM17    

Aliases
for TRIM17 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tripartite Motif Containing 171 2     Testis RING Finger Protein2 3
RNF161 2 3 5     Tripartite Motif-Containing Protein 172 3
RBCC1 2 3     E3 Ubiquitin-Protein Ligase TRIM172
Terf1     RING Finger Protein Terf2
Tripartite Motif-Containing 171 2     EC 6.3.2.-3
RING Finger Protein 162 3     TERF3

External Ids:    HGNC: 134301   Entrez Gene: 511272   Ensembl: ENSG000001629317   OMIM: 6061235   UniProtKB: Q9Y5773   

Export aliases for TRIM17 gene to outside databases

Previous GC identifers: GC01M227093 GC01M224334 GC01M224981 GC01M225570 GC01M224902 GC01M226662 GC01M199112


Summaries
for TRIM17 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TRIM17:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to
cytoplasmic bodies. The protein is expressed almost exclusively in the testis, but its function is unknown. Multiple
alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TRI17_HUMAN, Q9Y577
Function: May function as an ubiquitin E3 ligase




Genomic Views
for TRIM17 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM17 gene promoter:
         USF1   AML1a   p53   Pax-5   USF-1   NRSF form 1   COUP   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRIM17 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42

TRIM17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM17 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M228595:  view genomic region     (about GC identifiers)

Start:
 228,595,636 bp from pter      End:
 228,604,583 bp from pter
Size:
 8,948 bases      Orientation:
 minus strand

Proteins
for TRIM17 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TRI17_HUMAN, Q9Y577 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM17  
Size: 477 amino acids; 54418 Da
Subunit: Interacts (via coiled coil) with TRIM44 (via coiled coil)
Secondary accessions: B4DVJ2 Q5VST8
Alternative splicing: 2 isoforms:  Q9Y577-1   Q9Y577-2   

Explore the universe of human proteins at neXtProt for TRIM17: NX_Q9Y577

Post-translational modifications:

  • Auto-ubiquitinated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y577

    • TRIM17 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001020111.1  NP_001128327.1  NP_057186.1  

    ENSEMBL proteins: 
     ENSP00000355658   ENSP00000355659   ENSP00000295033   ENSP00000403312   ENSP00000430468  
     ENSP00000347794   ENSP00000397688   ENSP00000429555  

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    Uscn Proteins for TRIM17

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular IEA--


    TRIM17 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TRIM17 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRIM17 for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR006574 PRY
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q9Y577

    ProtoNet protein and cluster: Q9Y577

    4 Blocks protein families:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: TRI17_HUMAN, Q9Y577
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    Function
    for TRIM17 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TRI17_HUMAN, Q9Y577
    Function: May function as an ubiquitin E3 ligase

    Enzyme Number (IUBMB): EC 6.3.2.-1

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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA19358823
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--


    TRIM17 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TRIM17:
     Increased cell death HMECs cel 


    Pathways & Interactions
    for TRIM17 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: TRI17_HUMAN, Q9Y577
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/17 Interacting proteins for TRIM17 (Q9Y5771, 2, 3 ENSP000003477944) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM39Q9HCM91, 2, 3, ENSP000003658444EBI-743894,EBI-739510 MINT-66402 I2D: score=5 STRING: ENSP00000365844
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    TRIM44Q96DX73, ENSP000002994134I2D: score=1 STRING: ENSP00000299413
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051865protein autoubiquitination IDA19358823


    TRIM17 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRIM17 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM17
    Search CenterWatch for drugs/clinical trials and news about TRIM17 / TRI17 

    Transcripts
    for TRIM17 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRIM17 gene (4 alternative transcripts): 
    NM_001024940.2  NM_001134855.1  NM_016102.3  NM_001024941.2  

    Unigene Cluster for TRIM17:

    Tripartite motif containing 17
    Hs.121748  [show with all ESTs]
    Unigene Representative Sequence: NM_016102
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366697 ENST00000366698(uc001hsu.3) ENST00000295033(uc001hsv.3)
    ENST00000456946(uc009xfb.2) ENST00000479800 ENST00000355586 ENST00000457345
    ENST00000520264

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    Primer
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    Additional cDNA sequence: 

    AF156271.1 AK301105.1 AK308774.1 AK316379.1 BC023999.1 BC033788.1 

    7 DOTS entries:

    DT.95368363  DT.101963346  DT.406885  DT.121406801  DT.121406805  DT.95368362  DT.95290100 

    24 AceView cDNA sequences:

    AF156271 AK055426 NM_016102 AI809990 AW631254 BC033788 BC023999 CD242349 
    BI825739 AW770403 AA909463 BI828196 BI825903 AA758672 BQ073095 BM563820 
    BI825961 BG723626 AA781868 BI828234 BI831987 BF895293 BG990444 AW152318 

    GeneLoc Exon Structure


    Expression
    for TRIM17 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGGTGAAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TRIM17 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TRIM17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM17

    SOURCE GeneReport for Unigene cluster: Hs.121748

    UniProtKB/Swiss-Prot: TRI17_HUMAN, Q9Y577
    Tissue specificity: Almost exclusively in the testis

        SABiosciences Expression via Pathway-Focused PCR Array including TRIM17: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for TRIM17 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM17 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    zebrafish
    (Danio rerio)    		 Actinopterygii trim476
    		 tripartite motif containing 47
    		 24(a)
    		 possible ortholog
    		 10(26752552-26762609)


    ENSEMBL Gene Tree for TRIM17 (if available)
    TreeFam Gene Tree for TRIM17 (if available) 

    Paralogs
    for TRIM17 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM17 gene
    TRIM42  TRIM72  TRIM262  TRIM392  TRIM342  TRIML12  TRIM272  TRIM582  
    TRIM682  TRIM102  TRIM152  TRIM602  TRIM222  TRIM52  TRIM62  TRIM6-TRIM342  
    TRIM212  TRIM382  TRIM39-RPP212  TRIM112  
    18/34 SIMAP similar genes for TRIM17 using alignment to 6 protein entries:     TRI17_HUMAN (see all proteins) (see all similar genes):
    TRIM41    TRIM39    RFWD2    BFAR    RNF112    TRIM11
    TRIM4    TRIM68    TRIM60    TRIM73    TRIM58    TRIM5
    TRIM27    TRIM21    TRIM38    DKFZp686F23130    TRIM64C    TRIM22

    TRIM17 for paralogs           About GeneDecksing



    Genomic Variants
    for TRIM17 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/226 NCBI SNPs in TRIM17 are shown (see all 226)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1382640031,2
    		--228595141(+) CTGTTC/GCAGGC 3 -- ds5001 us2k10--------
    rs37683331,2
    		C,F,H--228595288(+) AAGGGC/TGCTGT 3 -- us2k1 ds50019Minor allele frequency- T:0.02EA NS NA 2236
    rs796547671,2
    		F,--228595407(+) GGTTCA/GGCCTT 3 -- us2k1 ds50011Minor allele frequency- G:0.08WA 118
    rs1159627371,2
    		C,F,--228595857(+) CCACAC/ACTTCT 3 -- ut31 us2k11Minor allele frequency- A:0.02WA 118
    rs13185881,2
    		H--228595909(+) ATCCTT/ATCACC 5 /K /I mis1 us2k1 ese34Minor allele frequency- A:0.00NA MN NS 472
    rs1139402471,2
    		C,F,--228595950(+) CCAGAC/TTTCGG 5 K us2k1 syn12Minor allele frequency- T:0.01CSA NA 4552
    rs617378021,2
    		C,F,--228595953(+) GACTTC/TGGAGC 5 P syn1 us2k14Minor allele frequency- T:0.03NS WA NA EU 5769
    rs1420389111,2
    		C,F,--228595962(+) GCCCCC/TAGGCA 5 L us2k1 syn11Minor allele frequency- T:0.00NA 4552
    rs1451119711,2
    		C,F--228596036(+) GCTTAC/TACTGT 6 I V mis1 ds5001 us2k11Minor allele frequency- T:0.00NA 4552
    rs1480814321,2
    		C,F--228596052(+) GACACA/G/TTCCCC 8 E D ds5001 mis1 us2k12NA EU 5875

    HapMap Linkage Disequilibrium report for TRIM17 (228595636 - 228604583 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for TRIM17
         4 CNVs: 48265 6812 48267 48266
    Human Gene Mutation Database (HGMD): TRIM17

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM17

    Disorders / Diseases
    for TRIM17 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRIM17 for disorders           About GeneDecksing

    OMIM gene information: 606123    OMIM disorders: --

    1 disease for TRIM17:    About MalaCards
    mulibrey nanism

    Human Genome Epidemiology (HuGE) Navigator: TRIM17 (1 document)

    Export disorders for TRIM17 gene to outside databases

    Publications
    for TRIM17 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM17 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with TRIM17)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis. (PubMed id 9792805)1, 2, 3, 9 Ogawa S....Inoue S. (1998)
    2. Chromosome mapping of RNF16 and rnf16, human, mouse a nd rat genes coding for testis RING finger protein (terf), a member of the RING finger family. (PubMed id 10894938)1, 3, 9 Ogawa S....Inoue S. (2000)
    3. TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase. (PubMed id 19358823)1, 2 Urano T.... Inoue S. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    7. Terf/TRIM17 stimulates degradation of kinetochore pro tein ZWINT and regulates cell proliferation. (PubMed id 22023800)1 Endo H....Inoue S. (2012)
    8. Functional interactions between ubiquitin E2 enzymes a nd TRIM proteins. (PubMed id 21143188)1 Napolitano L.M....Meroni G. (2011)
    9. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
    10. Candidate-gene testing for orphan limb-girdle muscula r dystrophies. (PubMed id 19472918)1 Aurino S....Nigro V. (2008)

    External Searches for TRIM17 gene

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    Genome Databases showing TRIM17 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51127 HGNC: 13430 AceView: TRIM17 Ensembl:ENSG00000162931 euGenes: HUgn51127
    ECgene: TRIM17 H-InvDB: TRIM17

    Other Databases showing TRIM17 gene

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    Specialized Databases showing TRIM17 gene

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    PharmGKB entry for TRIM17 Pharmacogenomics, SNPs, Pathways

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