TRIM16L Gene
protein-coding GIFtS: 43
GCID: GC17P018602
|
|
tripartite motif containing 16-like(Previous name: tripartite motif-containing 16-like )
| |
Aliases
for TRIM16L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tripartite Motif Containing 16-Like1 2 | | TRIM701 2 3 | | Tripartite Motif-Containing 16-Like1 2 | | Tripartite Motif-Containing Protein 702 3 | | Tripartite Motif Protein 702 | | Tripartite Motif-Containing Protein 16-Like Protein2 |
Export aliases for TRIM16L gene to outside databasesPrevious GC identifer: GC17P018547 |
Summaries
for TRIM16L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TRIM16L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRIM16L gene promoter:
Max1 Tal-1beta HNF-1A E47 c-Rel HNF-1 Hand1 Hlf c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIM16L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM16L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11.2TRIM16L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P018602: view genomic region
(about GC identifiers)
Start:
|
18,601,311 bp from pter |
End:
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18,639,431 bp from pter |
Size:
|
38,121 bases |
Orientation:
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plus strand |
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Proteins
for TRIM16L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TR16L_HUMAN, Q309B1 (See
protein sequence)Recommended Name: Tripartite motif-containing protein 16-like protein Size: 348 amino acids; 40306 Da
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: A0PK10 B2RUW6 B4DQK2 B4DWQ8Alternative splicing: 2 isoforms: Q309B1-1 Q309B1-2 Explore the universe of human proteins at neXtProt for TRIM16L: NX_Q309B1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q309B1
TRIM16L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001032407.1
ENSEMBL proteins: ENSP00000460272 ENSP00000461386 ENSP00000463750 ENSP00000459199 ENSP00000379030 ENSP00000460537 ENSP00000403648 ENSP00000399959 ENSP00000462695 ENSP00000459623 ENSP00000379239 ENSP00000379031
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
TRIM16L for ontologies About GeneDecksing
TRIM16L Antibody Products:
Assay Products for TRIM16L: |
Protein
Domains /
Families
for TRIM16L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIM16L for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q309B1ProtoNet protein and cluster: Q309B1 1 Blocks protein family: IPB003879 Butyrophylin C-terminal DUF signature
UniProtKB/Swiss-Prot: TR16L_HUMAN, Q309B1Similarity: Belongs to the TRIM/RBCC familySimilarity: Contains 1 B30.2/SPRY domain |
Function
for TRIM16L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM16L
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM16L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TRIM16L (NM_001037330) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM16L |
|
Pathways & Interactions
for TRIM16L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM16L
3 Interacting proteins for TRIM16L (Q309B13) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TRIM16L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRIM16L
Search CenterWatch for drugs/clinical trials and news about TRIM16L / TR16L
|
Transcripts
for TRIM16L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRIM16L gene: NM_001037330.1 Unigene Cluster for TRIM16L: Tripartite motif containing 16-like Hs.164324 [show with all ESTs]Unigene Representative Sequence: AK09539016 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000572555 ENST00000581904(uc002guf.2) ENST00000578086 ENST00000449552(uc010vyf.1 uc002gug.1 uc002guh.1 uc010cqg.1)
ENST00000449697 ENST00000571708 ENST00000573443 ENST00000395671(uc002gui.1 uc010vyg.1 uc010vyh.1)
ENST00000571542 ENST00000414850 ENST00000424146 ENST00000571733 ENST00000577969
ENST00000574042 ENST00000395902 ENST00000395672
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM16L
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM16L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRIM16L (NM_001037330) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM16L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM16L |
Additional cDNA sequence: AK057747.1 AK095390.1 AK293428.1 AK298836.1 AK301639.1 AK301647.1 AK316368.1 BC127827.1 BC128591.1 BC146902.1 BC146907.1 DQ232882.1 7 DOTS entries: DT.100790496 DT.92442958 DT.75114256 DT.120980248 DT.97848332 DT.92442965 DT.97816392 24/92 AceView cDNA sequences (see all 92): CB115986 BG420440 BQ944151 AI476375 BE272706 BQ952988 AI745151 BQ430050 CR594025 BP374882 BM807219 BQ943994 BF182998 BQ217372 BQ431174 BQ954488 BG490267 BM981643 AI745144 BG424431 BU163988 BG121532 AL080124 BV184558
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM16L (see all 9) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | · | 13c |
|---|
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| SP1: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | - | | | | - | | | | - | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | - | | - | | - | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for TRIM16L
|
Expression
for TRIM16L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRIM16L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTCTGGTTC
About this image
See TRIM16L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIM16L
SOURCE GeneReport for Unigene cluster: Hs.164324
SABiosciences Custom PCR Arrays for TRIM16L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM16L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TRIM16L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM16L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM16L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM16L |
Orthologs
for TRIM16L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TRIM16L gene from 2/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
41(a) |
1 → many |
2(107735073-107753248) |
zebrafish
(Danio rerio) |
Actinopterygii |
trim166 |
tripartite motif-containing 16 |
27(a) |
1 → many |
12(47709703-47754444) |
ENSEMBL Gene Tree for TRIM16L (if available)
TreeFam Gene Tree for TRIM16L (if available) |
Paralogs
for TRIM16L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRIM16L gene
- TRIM252 TRIM292 TRIM472 TRIM162 TRIM652 TRIM82
2 SIMAP similar genes for TRIM16L using alignment to 7 protein entries: TR16L_HUMAN (see all proteins):TRIM16 ERMAP
TRIM16L for paralogs About GeneDecksing
|
Genomic Variants
for TRIM16L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRIM16L (18601311 - 18639431 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for TRIM16L
3 CNVs: 4993 30808 5854
1 Indel: 25789 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM16L |
|
Disorders
/ Diseases
for TRIM16L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TRIM16L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRIM16L gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRIM16L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for TRIM16L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TRIM16L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRIM16L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRIM16L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TRIM16L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TRIM16L gene:
Search GeneIP for patents involving TRIM16L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRIM16L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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 | | | TRIM16L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM16L |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM16L |
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