Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIM16L Gene

Aliases for TRIM16L Gene

  • Tripartite Motif Containing 16-Like 2 3 5
  • Tripartite Motif-Containing Protein 70 3 4
  • TRIM70 3 4
  • Tripartite Motif-Containing Protein 16-Like Protein 3
  • Tripartite Motif-Containing 16-Like 2
  • Tripartite Motif Protein 70 3

External Ids for TRIM16L Gene

Previous GeneCards Identifiers for TRIM16L Gene

  • GC17P018547
  • GC17P018602

Summaries for TRIM16L Gene

GeneCards Summary for TRIM16L Gene

TRIM16L (Tripartite Motif Containing 16-Like) is a Protein Coding gene. An important paralog of this gene is TRIM16.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM16L Gene

Genomics for TRIM16L Gene

Regulatory Elements for TRIM16L Gene

Enhancers for TRIM16L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F018697 0.8 ENCODE 8.8 0.0 -12 1.1 HDAC1 ZNF133 ZNF76 ARID4B SIN3A DMAP1 ZNF2 ZBTB40 SCRT2 ZNF143 MFAP4 TVP23B TRIM16L FBXW10 ENSG00000264885 ZNF286B
GH17F018780 0.2 ENCODE 6.9 +83.2 83218 2.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF302 TVP23B MFAP4 FOXO3B ZNF286B SMCR8 ENSG00000264885 LOC100419436 DRG2 ENSG00000262202 TRIM16L
GH17F018919 1.1 FANTOM5 Ensembl ENCODE 1.5 +223.3 223346 3.4 PKNOX1 ARID4B SIN3A CBX5 ZNF207 JUNB TBX21 MIER3 PBX2 NBN ENSG00000212618 SLC5A10 ENSG00000196893 PRPSAP2 TVP23B FAM83G TRIM16L LOC100419620 GC17P018945
GH17F018681 0.8 ENCODE 0.3 -15.6 -15646 1.1 ATF1 CREB3L1 ZNF76 SIN3A BRCA1 ZEB1 ZNF121 GLIS2 ZNF366 SCRT2 TVP23B MFAP4 FOXO3B ENSG00000264885 PRPSAP2 SHMT1 ZNF286B TRIM16L
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TRIM16L on UCSC Golden Path with GeneCards custom track

Promoters for TRIM16L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001534741 3 1200 HDAC1 ZNF133 ZNF76 ARID4B SIN3A DMAP1 ZNF2 ZBTB40 SCRT2 ZNF143

Genomic Location for TRIM16L Gene

Chromosome:
17
Start:
18,697,998 bp from pter
End:
18,736,118 bp from pter
Size:
38,121 bases
Orientation:
Plus strand

Genomic View for TRIM16L Gene

Genes around TRIM16L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM16L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM16L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM16L Gene

Proteins for TRIM16L Gene

  • Protein details for TRIM16L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q309B1-TR16L_HUMAN
    Recommended name:
    Tripartite motif-containing protein 16-like protein
    Protein Accession:
    Q309B1
    Secondary Accessions:
    • A0PK10
    • B2RUW6
    • B4DQK2
    • B4DWQ8

    Protein attributes for TRIM16L Gene

    Size:
    348 amino acids
    Molecular mass:
    40306 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIM16L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM16L Gene

Post-translational modifications for TRIM16L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM16L Gene

Domains & Families for TRIM16L Gene

Protein Domains for TRIM16L Gene

Suggested Antigen Peptide Sequences for TRIM16L Gene

Graphical View of Domain Structure for InterPro Entry

Q309B1

UniProtKB/Swiss-Prot:

TR16L_HUMAN :
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
Domain:
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM16L: view

No data available for Gene Families for TRIM16L Gene

Function for TRIM16L Gene

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM16L Gene

Localization for TRIM16L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM16L Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM16L Gene COMPARTMENTS Subcellular localization image for TRIM16L gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRIM16L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TRIM16L: view

Pathways & Interactions for TRIM16L Gene

SuperPathways for TRIM16L Gene

No Data Available

Interacting Proteins for TRIM16L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000379030%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000379030 Q309B1-TR16L_HUMAN for TRIM16L Gene via STRING IID

Gene Ontology (GO) - Biological Process for TRIM16L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRIM16L Gene

Transcripts for TRIM16L Gene

Unigene Clusters for TRIM16L Gene

Tripartite motif containing 16-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM16L Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a · 13b · 13c
SP1: - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - -
SP7: -
SP8: -
SP9:

Relevant External Links for TRIM16L Gene

GeneLoc Exon Structure for
TRIM16L
ECgene alternative splicing isoforms for
TRIM16L

Expression for TRIM16L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM16L Gene

Protein differential expression in normal tissues from HIPED for TRIM16L Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRIM16L Gene



Protein tissue co-expression partners for TRIM16L Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM16L Gene:

TRIM16L

SOURCE GeneReport for Unigene cluster for TRIM16L Gene:

Hs.745311
genes like me logo Genes that share expression patterns with TRIM16L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIM16L Gene

Orthologs for TRIM16L Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM16L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM16L 34 35
  • 98.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 66 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Trim16 35
  • 53 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 41 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 35 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii trim16 35
  • 27 (a)
OneToMany
Species where no ortholog for TRIM16L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM16L Gene

ENSEMBL:
Gene Tree for TRIM16L (if available)
TreeFam:
Gene Tree for TRIM16L (if available)

Paralogs for TRIM16L Gene

Paralogs for TRIM16L Gene

(2) SIMAP similar genes for TRIM16L Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TRIM16L: view

Variants for TRIM16L Gene

Sequence variations from dbSNP and Humsavar for TRIM16L Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1004013 -- 18,723,887(-) CTCCC(A/C)TTGAG intron-variant
rs10153266 -- 18,729,432(+) tcttt(C/T)ccccc intron-variant
rs10153270 -- 18,729,516(+) tcagc(C/G)tcccg intron-variant
rs10153316 -- 18,731,637(+) CCACC(A/G)TGCCC intron-variant
rs10633917 -- 18,708,586(+) TGGTT(-/AT)GCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM16L Gene

Variant ID Type Subtype PubMed ID
dgv564e214 CNV gain 21293372
esv1199476 CNV deletion 17803354
esv3554224 CNV deletion 23714750
esv3640164 CNV gain 21293372
nsv1055999 CNV gain 25217958
nsv1057803 CNV loss 25217958
nsv1060744 CNV gain 25217958
nsv1063354 CNV gain 25217958
nsv1075927 CNV duplication 25765185
nsv112212 CNV deletion 16902084
nsv1131301 CNV deletion 24896259
nsv499818 OTHER inversion 21111241
nsv523721 CNV gain 19592680
nsv833389 CNV gain 17160897
nsv9504 CNV gain+loss 18304495
nsv960430 CNV duplication 23825009
nsv962278 CNV duplication 23825009

Variation tolerance for TRIM16L Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.82; 83.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM16L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM16L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM16L Gene

Disorders for TRIM16L Gene

Relevant External Links for TRIM16L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM16L

No disorders were found for TRIM16L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM16L Gene

Publications for TRIM16L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TRIM16L Gene

Sources for TRIM16L Gene

Content
Loading form....