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TRIM16 Gene

protein-coding   GIFtS: 50
GCID: GC17M015531

Tripartite Motif Containing 16

(Previous name: tripartite motif-containing 16)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Tripartite Motif Containing 161 2
Estrogen-Responsive B Box Protein1 2 3
Tripartite Motif-Containing 161 2
EBBP2 3
Tripartite Motif-Containing Protein 162

External Ids:    HGNC: 172411   Entrez Gene: 106262   Ensembl: ENSG000002219267   OMIM: 6095055   UniProtKB: O953613   
ORGUL members:         

Export aliases for TRIM16 gene to outside databases

Previous GC identifers: GC17M015897 GC17M016646 GC17M015474 GC17M015731 GC17M015472 GC17M015404


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIM16 Gene:
This gene was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing
estrogen receptor. The protein encoded by this gene contains two B box domains and a coiled-coiled region that
are characteristic of the B box zinc finger protein family. The proteins of this family have been reported to be
involved in a variety of biological processes including cell growth, differentiation and pathogenesis. Expression
of this gene was detected in most tissues. Its function, however, has not yet been determined. (provided by
RefSeq, Jul 2008)

GeneCards Summary for TRIM16 Gene:
TRIM16 (tripartite motif containing 16) is a protein-coding gene. Diseases associated with TRIM16 include skin squamous cell carcinoma, and actinic keratosis. GO annotations related to this gene include interleukin-1 binding and NACHT domain binding. An important paralog of this gene is ENSG00000251537.

UniProtKB/Swiss-Prot: TRI16_HUMAN, O95361
Function: May play a role in the regulation of keratinocyte differentiation

Gene Wiki entry for TRIM16 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM16 gene promoter:
         Pbx1a   FOXL1   Evi-1   AREB6   PPAR-gamma1   POU2F1   POU2F1a   STAT3   PPAR-gamma2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM16 promoter sequence
   Search Chromatin IP Primers for TRIM16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p12   HGNC cytogenetic band: 17p11.2

TRIM16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM16 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M015531:  view genomic region     (about GC identifiers)

Start:
15,531,274 bp from pter      End:
15,587,625 bp from pter
Size:
56,352 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TRI16_HUMAN, O95361 (See protein sequence)
Recommended Name: Tripartite motif-containing protein 16  
Size: 564 amino acids; 63955 Da
Secondary accessions: Q6IAL8 Q7Z6I2 Q96BE8 Q96J43
Alternative splicing: 2 isoforms:  O95361-1   O95361-2   

Explore the universe of human proteins at neXtProt for TRIM16: NX_O95361

Explore proteomics data for TRIM16 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRIM16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006461.3  
    ENSEMBL proteins: 
     ENSP00000462903   ENSP00000399918   ENSP00000463188   ENSP00000467031   ENSP00000463639  
     ENSP00000464072   ENSP00000463293   ENSP00000465907   ENSP00000463360   ENSP00000465169  
     ENSP00000338989  

    TRIM16 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing

    Selected InterPro protein domains (see all 7):
     IPR006574 PRY
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt
     IPR000315 Znf_B-box
     IPR018355 SPla/RYanodine_receptor_subgr

    Graphical View of Domain Structure for InterPro Entry O95361

    ProtoNet protein and cluster: O95361

    3 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: TRI16_HUMAN, O95361
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 2 B box-type zinc fingers
    Similarity: Contains 1 B30.2/SPRY domain


    TRIM16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI16_HUMAN, O95361
    Function: May play a role in the regulation of keratinocyte differentiation

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IDA16636064
    GO:0005515protein binding IPI16575408
    GO:0008270zinc ion binding IEA--
    GO:0019966interleukin-1 binding IPI16575408
         
    TRIM16 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM16
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM16
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM16

    miRNA
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    miRTarBase miRNAs that target TRIM16:
    hsa-mir-335-5p (MIRT017852)

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    2 qRT-PCR Assays for microRNAs that regulate TRIM16:
    hsa-miR-612 hsa-miR-1285
    SwitchGear 3'UTR luciferase reporter plasmidTRIM16 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRIM16

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRI16_HUMAN, O95361: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA11919186
    GO:0016605PML body IDA16636064

    TRIM16 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRIM16
    Interactions:

        Search GeneGlobe Interaction Network for TRIM16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for TRIM16 (O953611, 2, 3 ENSP000003389894) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    E2F1Q010941, 3, ENSP000003455714EBI-727384,EBI-448924 I2D: score=1 STRING: ENSP00000345571
    SETDB1Q150472, 3MINT-63287 I2D: score=4 
    VIMP086701, 3, ENSP000002242374EBI-727384,EBI-353844 I2D: score=1 STRING: ENSP00000224237
    RBP3ENSP000002246004STRING: ENSP00000224600
    ACDENSP000003774964STRING: ENSP00000377496
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0032526response to retinoic acid IEP16636064
    GO:0043966histone H3 acetylation IDA19147277
    GO:0043967histone H4 acetylation IDA16636064
    GO:0045618positive regulation of keratinocyte differentiation IDA11919186

    TRIM16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM16 (TRI16)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRIM16 gene: 
    NM_006470.3  

    Unigene Cluster for TRIM16:

    Tripartite motif containing 16
    Hs.123534  [show with all ESTs]
    Unigene Representative Sequence: BX537711
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000577886(uc002gow.3) ENST00000416464(uc002goy.3) ENST00000578237(uc002gox.3)
    ENST00000577446 ENST00000579219 ENST00000577326 ENST00000580110 ENST00000473368
    ENST00000577372 ENST00000578744 ENST00000473540 ENST00000581224 ENST00000581200
    ENST00000460728 ENST00000579272 ENST00000584142 ENST00000473659 ENST00000494759

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate TRIM16:
    hsa-miR-612 hsa-miR-1285
    SwitchGear 3'UTR luciferase reporter plasmidTRIM16 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat TRIM16
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    GenScript: all cDNA clones in your preferred vector: TRIM16 (NM_006470)
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      QuantiTect SYBR Green Assays in human, mouse, rat TRIM16
      QuantiFast Probe-based Assays in human, mouse, rat TRIM16

    Additional mRNA sequence: 

    AF096870.1 AK002035.1 AK056026.1 AK314557.1 BC001564.1 BC015674.2 BC053514.1 BC067096.1 
    BX537711.1 CR457136.1 

    21 DOTS entries:

    DT.92442965  DT.97848333  DT.120914046  DT.120914029  DT.97767472  DT.100790496  DT.120913987  DT.92442956 
    DT.100738445  DT.120914055  DT.120914028  DT.120914031  DT.120914035  DT.120914057  DT.92020961  DT.92442966 
    DT.100790490  DT.100790499  DT.91939264  DT.92442958  DT.97848332 

    Selected AceView cDNA sequences (see all 186):

    BU838716 BU167981 BF182998 CB144115 AI811460 BQ682239 BG059523 BM772565 
    BM794887 BQ918457 BQ949192 BM750881 BQ217870 BG420440 BQ214657 BM772725 
    BM773206 BC001564 BX476311 BM764521 BU185583 CB115352 BM763756 AL602673 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TRIM16 Expression
    About this image


    TRIM16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Testis (Reproductive System)
     
     Esophagus (Gastrointestinal Tract)
    TRIM16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.123534

    UniProtKB/Swiss-Prot: TRI16_HUMAN, O95361
    Tissue specificity: Highest levels found in testis, ovary, small intestine, colon, placenta, heart, skeletal
    muscle and mammary gland. More highly expressed in the fetus than in the corresponding adult tissues. Expressed
    in basal keratinocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM16 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim161 , 5 tripartite motif-containing 161, 5 81.2(n)1
    77.84(a)1
      11 (38.75 cM)5
    940921  NM_053169.21  NP_444399.21 
     628202315 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    49(a)
    1 → many
    2(107734930-107753455)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004905561 tripartite motif-containing protein 16-like 61.98(n)
    52.69(a)
      100490556  XM_002941088.2  XP_002941134.2 
    zebrafish
    (Danio rerio)
    Actinopterygii trim161 tripartite motif-containing 16 55.78(n)
    46.14(a)
      568734  XM_001921054.5  XP_001921089.3 


    ENSEMBL Gene Tree for TRIM16 (if available)
    TreeFam Gene Tree for TRIM16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM16 gene
    ENSG000002515372  TRIM252  TRIM292  TRIM16L2  TRIM472  TRIM652  
    1 SIMAP similar gene for TRIM16 using alignment to 9 protein entries:     TRI16_HUMAN (see all proteins):
    TRIM16L

    TRIM16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM16 (see all 1228)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1133155801,2
    C,F--15530863(+) AACACG/AGTGAA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1895351611,2
    C--15530873(+) AACCCC/TGTCTC 1 -- ds50010--------
    rs1427716091,2
    C--15531202(+) TATAAC/GCATCT 1 -- ds50010--------
    rs1814273101,2
    --15531282(+) AAATAC/TGCAAG 1 -- ut310--------
    rs1837091871,2
    --15531295(+) AGCAAC/TTTATT 1 -- ut310--------
    rs1884214131,2
    --15531434(+) ATTACG/TACAAA 1 -- ut310--------
    rs1494463471,2
    C--15531449(+) CAGGGC/TGCAGT 1 -- ut310--------
    rs11381161,2
    C--15531496(-) TGCACC/TCACCT 1 -- ut313Minor allele frequency- T:0.17NA 6
    rs11381131,2
    C--15531514(-) AAACTC/TCTGAC 1 -- ut314Minor allele frequency- T:0.19MN NA 190
    rs1818184201,2
    --15531573(+) AAAACA/GTTAGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TRIM16 (15531274 - 15587625 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TRIM16:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2421995CNV Deletion20811451
    nsv522130CNV Loss19592680
    nsv518620CNV Loss19592680
    nsv520426CNV Loss19592680
    nsv907704CNV Gain21882294
    nsv457695CNV Gain19166990
    nsv442736CNV CNV18776908

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM16
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609505    OMIM disorders: --

    5 diseases for TRIM16:    
    About MalaCards
    skin squamous cell carcinoma    actinic keratosis    keratosis    neuroblastoma
    squamous cell carcinoma


    TRIM16 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRIM16

    Export disorders for TRIM16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM16 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with TRIM16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The novel estrogen-responsive B box protein (EBBP) gene is tamoxifen regulated in cells expressing an estrogen receptor DNA-binding domain mutant. (PubMed id 9817599)1, 2, 9 Liu H.-L.C....Zajchowski D.A. (Mol. Endocrinol. 1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The estrogen-responsive B box protein: a novel regulator of keratinocyte differentiation. (PubMed id 11919186)1, 2 Beer H.-D.... Werner S. (J. Biol. Chem. 2002)
    4. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 3 Reymond A.... Ballabio A. (EMBO J. 2001)
    5. The estrogen-responsive B box protein (EBBP) restores retinoid sensitivity in retinoid-resistant cancer cells via effects on histone acetylation. (PubMed id 19147277)1, 9 Raif A....Cheung B.B. (Cancer Lett. 2009)
    6. Differential gene expression in normal human mammary epithelial cells treated with malathion monitored by DNA microarrays. (PubMed id 16079077)1, 9 Gwinn M.R....Weston A. (Environ. Health Perspect. 2005)
    7. TRIM16 inhibits neuroblastoma cell proliferation through cell cycle regulation and dynamic nuclear localization. (PubMed id 23422002)1 Bell J.L....Cheung B.B. (Cell Cycle 2013)
    8. TRIM16 overexpression induces apoptosis through activation of caspase-2 in cancer cells. (PubMed id 23404198)1 Kim P.Y....Cheung B.B. (Apoptosis 2013)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members. (PubMed id 22629402)1 Bell J.L....Cheung B.B. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10626 HGNC: 17241 AceView: TRIM16 Ensembl:ENSG00000221926 euGenes: HUgn10626
    ECgene: TRIM16 H-InvDB: TRIM16

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRIM16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM16 gene:
    Search GeneIP for patents involving TRIM16

    GeneCards and IP:
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