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Aliases for TRIM16 Gene

Aliases for TRIM16 Gene

  • Tripartite Motif Containing 16 2 3 5
  • Estrogen-Responsive B Box Protein 2 3 4
  • Tripartite Motif-Containing 16 2 3
  • EBBP 3 4

External Ids for TRIM16 Gene

Previous GeneCards Identifiers for TRIM16 Gene

  • GC17M015897
  • GC17M016646
  • GC17M015474
  • GC17M015731
  • GC17M015472
  • GC17M015531
  • GC17M015404

Summaries for TRIM16 Gene

Entrez Gene Summary for TRIM16 Gene

  • This gene was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. The protein encoded by this gene contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. The proteins of this family have been reported to be involved in a variety of biological processes including cell growth, differentiation and pathogenesis. Expression of this gene was detected in most tissues. Its function, however, has not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM16 Gene

TRIM16 (Tripartite Motif Containing 16) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and NACHT domain binding. An important paralog of this gene is TRIM16L.

UniProtKB/Swiss-Prot for TRIM16 Gene

  • May play a role in the regulation of keratinocyte differentiation.

Gene Wiki entry for TRIM16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM16 Gene

Genomics for TRIM16 Gene

Regulatory Elements for TRIM16 Gene

Enhancers for TRIM16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM16 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM16 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM16 Gene

15,627,960 bp from pter
15,684,311 bp from pter
56,352 bases
Minus strand

Genomic View for TRIM16 Gene

Genes around TRIM16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM16 Gene

Proteins for TRIM16 Gene

  • Protein details for TRIM16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 16
    Protein Accession:
    Secondary Accessions:
    • Q6IAL8
    • Q7Z6I2
    • Q96BE8
    • Q96J43

    Protein attributes for TRIM16 Gene

    564 amino acids
    Molecular mass:
    63955 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIM16 Gene


neXtProt entry for TRIM16 Gene

Proteomics data for TRIM16 Gene at MOPED

Post-translational modifications for TRIM16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM16 Gene

Domains & Families for TRIM16 Gene

Gene Families for TRIM16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 2 B box-type zinc fingers.
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 2 B box-type zinc fingers.
genes like me logo Genes that share domains with TRIM16: view

Function for TRIM16 Gene

Molecular function for TRIM16 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the regulation of keratinocyte differentiation.

Phenotypes for TRIM16 Gene

genes like me logo Genes that share phenotypes with TRIM16: view

Animal Model Products

miRNA for TRIM16 Gene

miRTarBase miRNAs that target TRIM16

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM16 Gene

Localization for TRIM16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM16 Gene


Subcellular locations from

Jensen Localization Image for TRIM16 Gene COMPARTMENTS Subcellular localization image for TRIM16 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for TRIM16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016605 PML body IDA 16636064
genes like me logo Genes that share ontologies with TRIM16: view

Pathways & Interactions for TRIM16 Gene

SuperPathways for TRIM16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0043967 histone H4 acetylation IDA 16636064
GO:0045893 positive regulation of transcription, DNA-templated IDA 16636064
GO:0048386 positive regulation of retinoic acid receptor signaling pathway IDA 16636064
GO:0050718 positive regulation of interleukin-1 beta secretion IMP 16575408
genes like me logo Genes that share ontologies with TRIM16: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM16 Gene

Drugs & Compounds for TRIM16 Gene

No Compound Related Data Available

Transcripts for TRIM16 Gene

Unigene Clusters for TRIM16 Gene

Tripartite motif containing 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM16 Gene

No ASD Table

Relevant External Links for TRIM16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM16 Gene

mRNA expression in normal human tissues for TRIM16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRIM16 Gene

This gene is overexpressed in Cervix (51.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM16 Gene

SOURCE GeneReport for Unigene cluster for TRIM16 Gene Hs.123534

mRNA Expression by UniProt/SwissProt for TRIM16 Gene

Tissue specificity: Highest levels found in testis, ovary, small intestine, colon, placenta, heart, skeletal muscle and mammary gland. More highly expressed in the fetus than in the corresponding adult tissues. Expressed in basal keratinocytes.
genes like me logo Genes that share expression patterns with TRIM16: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for TRIM16 Gene

Orthologs for TRIM16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIM16 35
  • 79.52 (n)
  • 74.59 (a)
(Canis familiaris)
Mammalia LOC489518 35
  • 84.34 (n)
  • 81.72 (a)
(Mus musculus)
Mammalia Trim16 35
  • 81.2 (n)
  • 77.84 (a)
Trim16 16
Trim16 36
  • 78 (a)
(Pan troglodytes)
Mammalia TRIM16 35
  • 97.16 (n)
  • 96.63 (a)
TRIM16 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Trim16 35
  • 80.9 (n)
  • 76.76 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490556 35
  • 61.98 (n)
  • 52.69 (a)
(Danio rerio)
Actinopterygii trim16 35
  • 55.78 (n)
  • 46.14 (a)
trim16 36
  • 40 (a)
Species with no ortholog for TRIM16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM16 Gene

Gene Tree for TRIM16 (if available)
Gene Tree for TRIM16 (if available)

Paralogs for TRIM16 Gene

Paralogs for TRIM16 Gene

(1) SIMAP similar genes for TRIM16 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with TRIM16: view

Variants for TRIM16 Gene

Sequence variations from dbSNP and Humsavar for TRIM16 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2074890 - 15,651,247(-) ACCGA(A/G/T)CCAGT reference, missense
rs1060903 - 15,628,628(-) GGTGG(G/T)GACTG reference, missense
rs3174720 - 15,628,833(-) CTTTC(C/T)GGAGG reference, missense
rs110675 -- 15,675,538(+) ATAAA(A/G)GTCTA intron-variant
rs149261 -- 15,683,986(-) ACCTC(C/T)GGGTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIM16 Gene

Variant ID Type Subtype PubMed ID
nsv457695 CNV Gain 19166990
esv2421995 CNV Deletion 20811451
nsv907704 CNV Gain 21882294
nsv442736 CNV CNV 18776908
nsv520426 CNV Loss 19592680
nsv522130 CNV Loss 19592680
nsv518620 CNV Loss 19592680

Variation tolerance for TRIM16 Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.71; 66.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRIM16 Gene

Disorders for TRIM16 Gene

Relevant External Links for TRIM16

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRIM16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM16 Gene

Publications for TRIM16 Gene

  1. The novel estrogen-responsive B box protein (EBBP) gene is tamoxifen regulated in cells expressing an estrogen receptor DNA-binding domain mutant. (PMID: 9817599) Liu H.-L.C. … Zajchowski D.A. (Mol. Endocrinol. 1998) 3 4 23 67
  2. The estrogen-responsive B box protein (EBBP) restores retinoid sensitivity in retinoid-resistant cancer cells via effects on histone acetylation. (PMID: 19147277) Raif A. … Cheung B.B. (Cancer Lett. 2009) 3 23
  3. Differential gene expression in normal human mammary epithelial cells treated with malathion monitored by DNA microarrays. (PMID: 16079077) Gwinn M.R. … Weston A. (Environ. Health Perspect. 2005) 3 23
  4. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3
  5. Tripartite motif 16 inhibits epithelial-mesenchymal transition and metastasis by down-regulating sonic hedgehog pathway in non-small cell lung cancer cells. (PMID: 25843803) Huo X. … Yao Y. (Biochem. Biophys. Res. Commun. 2015) 3

Products for TRIM16 Gene

Sources for TRIM16 Gene