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Aliases for TRIM16 Gene

Aliases for TRIM16 Gene

  • Tripartite Motif Containing 16 2 3 5
  • Estrogen-Responsive B Box Protein 2 3 4
  • EBBP 3 4
  • Tripartite Motif-Containing Protein 16 3
  • Tripartite Motif-Containing 16 2

External Ids for TRIM16 Gene

Previous GeneCards Identifiers for TRIM16 Gene

  • GC17M015897
  • GC17M016646
  • GC17M015474
  • GC17M015731
  • GC17M015472
  • GC17M015531
  • GC17M015404

Summaries for TRIM16 Gene

Entrez Gene Summary for TRIM16 Gene

  • The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, the encoded protein can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity. This gene is also a tumor suppressor and is involved in secretory autophagy. [provided by RefSeq, Jan 2017]

GeneCards Summary for TRIM16 Gene

TRIM16 (Tripartite Motif Containing 16) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and NACHT domain binding. An important paralog of this gene is TRIM16L.

UniProtKB/Swiss-Prot for TRIM16 Gene

  • May play a role in the regulation of keratinocyte differentiation.

Gene Wiki entry for TRIM16 Gene

Additional gene information for TRIM16 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM16 Gene

Genomics for TRIM16 Gene

Regulatory Elements for TRIM16 Gene

Enhancers for TRIM16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H015661 0.2 dbSUPER 7.1 +21.1 21055 2.8 TRIM16 CDRT4 CENPV ENSG00000251537 ZNF29P
GH17H014840 0.2 ENCODE 6.3 +843.6 843618 1.3 ENSG00000205325 TRIM16 LINC02096 GC17P014907
GH17H015683 0.9 ENCODE 0.7 +0.1 95 0.9 HDAC1 PKNOX1 ZNF133 ARID4B SIN3A ZNF76 DMAP1 ZBTB40 ETS1 SCRT2 TBC1D26 TRIM16 ZNF29P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM16 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000091666 11 1000 HDAC1 PKNOX1 ZNF133 ARID4B SIN3A ZNF76 ZBTB40 ETS1 SCRT2 ZNF143

Genomic Locations for TRIM16 Gene

Genomic Locations for TRIM16 Gene
56,352 bases
Minus strand

Genomic View for TRIM16 Gene

Genes around TRIM16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM16 Gene

Proteins for TRIM16 Gene

  • Protein details for TRIM16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 16
    Protein Accession:
    Secondary Accessions:
    • Q6IAL8
    • Q7Z6I2
    • Q96BE8
    • Q96J43

    Protein attributes for TRIM16 Gene

    564 amino acids
    Molecular mass:
    63955 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIM16 Gene


neXtProt entry for TRIM16 Gene

Post-translational modifications for TRIM16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM16 Gene

Domains & Families for TRIM16 Gene

Gene Families for TRIM16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM16: view

Function for TRIM16 Gene

Molecular function for TRIM16 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the regulation of keratinocyte differentiation.

Gene Ontology (GO) - Molecular Function for TRIM16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 16636064
GO:0005515 protein binding IPI 16575408
GO:0008270 zinc ion binding IEA --
GO:0019966 interleukin-1 binding IPI 16575408
GO:0032089 NACHT domain binding IPI 16575408
genes like me logo Genes that share ontologies with TRIM16: view

Phenotypes for TRIM16 Gene

genes like me logo Genes that share phenotypes with TRIM16: view

miRNA for TRIM16 Gene

miRTarBase miRNAs that target TRIM16

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM16 Gene

Localization for TRIM16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM16 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM16 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 4
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IDA,IEA 9817599
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0016605 PML body IDA 16636064
genes like me logo Genes that share ontologies with TRIM16: view

Pathways & Interactions for TRIM16 Gene

SuperPathways for TRIM16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0032526 response to retinoic acid IEP 16636064
GO:0043966 histone H3 acetylation IDA 19147277
GO:0043967 histone H4 acetylation IDA 16636064
GO:0045618 positive regulation of keratinocyte differentiation IDA 11919186
genes like me logo Genes that share ontologies with TRIM16: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM16 Gene

Drugs & Compounds for TRIM16 Gene

No Compound Related Data Available

Transcripts for TRIM16 Gene

Unigene Clusters for TRIM16 Gene

Tripartite motif containing 16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM16 Gene

No ASD Table

Relevant External Links for TRIM16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRIM16 Gene

This gene is overexpressed in Cervix (51.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM16 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM16 Gene:


SOURCE GeneReport for Unigene cluster for TRIM16 Gene:


mRNA Expression by UniProt/SwissProt for TRIM16 Gene:

Tissue specificity: Highest levels found in testis, ovary, small intestine, colon, placenta, heart, skeletal muscle and mammary gland. More highly expressed in the fetus than in the corresponding adult tissues. Expressed in basal keratinocytes.

Evidence on tissue expression from TISSUES for TRIM16 Gene

  • Skin(4.6)
  • Lung(3.1)
  • Nervous system(3)
genes like me logo Genes that share expression patterns with TRIM16: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM16 Gene

Orthologs for TRIM16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM16 33 34
  • 97.16 (n)
(Canis familiaris)
Mammalia LOC489518 33
  • 84.34 (n)
(Mus musculus)
Mammalia Trim16 33 16 34
  • 81.2 (n)
(Rattus norvegicus)
Mammalia Trim16 33
  • 80.9 (n)
(Bos Taurus)
Mammalia TRIM16 33
  • 79.52 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 67 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 60 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490556 33
  • 61.98 (n)
(Danio rerio)
Actinopterygii trim16 33 34
  • 55.78 (n)
Species where no ortholog for TRIM16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM16 Gene

Gene Tree for TRIM16 (if available)
Gene Tree for TRIM16 (if available)

Paralogs for TRIM16 Gene

Paralogs for TRIM16 Gene

(1) SIMAP similar genes for TRIM16 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with TRIM16: view

Variants for TRIM16 Gene

Sequence variations from dbSNP and Humsavar for TRIM16 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000083719 -- 15,651,785(+) GATGG(C/T)AGCCA utr-variant-5-prime
rs1000226461 -- 15,673,636(+) AATAA(A/T)TCATG intron-variant
rs1000240327 -- 15,645,577(+) AAAAA(A/C)AAAAA intron-variant
rs1000248219 -- 15,651,079(+) GGTCC(C/G)CAAGC intron-variant
rs1000260610 -- 15,673,957(+) TTCCA(A/G)GGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM16 Gene

Variant ID Type Subtype PubMed ID
nsv978369 CNV duplication 23825009
nsv978368 CNV duplication 23825009
nsv962261 CNV duplication 23825009
nsv960058 CNV duplication 23825009
nsv953832 CNV deletion 24416366
nsv574462 CNV gain 21841781
nsv522130 CNV loss 19592680
nsv520426 CNV loss 19592680
nsv518620 CNV loss 19592680
nsv457695 CNV gain 19166990
nsv442736 CNV loss 18776908
nsv1160455 CNV deletion 26073780
nsv1160454 CNV deletion 26073780
nsv1136229 CNV deletion 24896259
nsv1067123 CNV loss 25217958
esv3892964 CNV gain 25118596
esv3640078 CNV gain 21293372
esv3582544 CNV loss 25503493
esv3432585 CNV insertion 20981092
esv2421995 CNV deletion 20811451
dgv890e212 CNV loss 25503493

Variation tolerance for TRIM16 Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.71; 66.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM16 Gene

Disorders for TRIM16 Gene

Relevant External Links for TRIM16

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRIM16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM16 Gene

Publications for TRIM16 Gene

  1. The novel estrogen-responsive B-box protein (EBBP) gene is tamoxifen-regulated in cells expressing an estrogen receptor DNA-binding domain mutant. (PMID: 9817599) Liu HL … Zajchowski DA (Molecular endocrinology (Baltimore, Md.) 1998) 3 4 22 60
  2. The estrogen-responsive B box protein (EBBP) restores retinoid sensitivity in retinoid-resistant cancer cells via effects on histone acetylation. (PMID: 19147277) Raif A … Cheung BB (Cancer letters 2009) 3 22 60
  3. Differential gene expression in normal human mammary epithelial cells treated with malathion monitored by DNA microarrays. (PMID: 16079077) Gwinn MR … Weston A (Environmental health perspectives 2005) 3 22 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The estrogen-responsive B box protein: a novel regulator of keratinocyte differentiation. (PMID: 11919186) Beer HD … Werner S (The Journal of biological chemistry 2002) 3 4 60

Products for TRIM16 Gene

Sources for TRIM16 Gene

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