Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRIM15 Gene

protein-coding GIFtS: 51
GCID: GC06P030130

Tripartite Motif Containing 15

(Previous names: zinc finger protein 178, tripartite motif-containing 15)
(Previous symbol: ZNF178)

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Tripartite Motif Containing 15¹ ²		RNF93² ³
Zinc Finger Protein 178¹ ² ³		ZNFB7² ³
ZNF178¹ ² ³		RING Finger Protein 93² ³
Tripartite Motif-Containing 15¹ ²		Tripartite Motif-Containing Protein 15²
Zinc Finger Protein B7² ³

External Ids:	HGNC: 16284¹	Entrez Gene: 89870²	Ensembl: ENSG00000204610⁷	UniProtKB: Q9C019³

Export aliases for TRIM15 gene to outside databases

Previous GC identifers: GC06P030215 GC06P029901 GC06P030237 GC06P030238 GC06P029929

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRIM15 Gene:

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three

zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes

to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity

has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRIM15 Gene:

TRIM15 (tripartite motif containing 15) is a protein-coding gene. Diseases associated with TRIM15 include hemochromatosis, and systemic lupus erythematosus. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is TRIM7.

Gene Wiki entry for TRIM15 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167246.1 NT_167247.1 NT_167248.1

NT_167249.1 NC_018917.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRIM15 gene promoter:
Max1 AML1a MyoD Nkx2-5 c-Ets-1 Arnt MZF-1 E2F-1 E2F
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TRIM15 promoter sequence

Search SABiosciences Chromatin IP Primers for TRIM15

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM15

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p22.1 HGNC cytogenetic band: 6p21.33

TRIM15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM15 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P030130: view genomic region (about GC identifiers)

Start:	30,130,983 bp from pter	End:	30,140,473 bp from pter
Size:	9,491 bases	Orientation:	plus strand

6/7 alternative locations (see all 7):

Chr6+,NT_167245 1,424,692-1,434,182	Chr6+,NT_113891.2 1,643,110-1,652,600	Chr6+,NT_167249 1,461,435-1,470,925
Chr6+,NT_167247 1,512,864-1,522,354	Chr6+,NT_167248 1,423,930-1,433,420	Chr6+,NT_167246 1,479,528-1,489,018

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRI15_HUMAN, Q9C019 (See protein sequence)

Recommended Name: Tripartite motif-containing protein 15

Size: 465 amino acids; 52113 Da

Secondary accessions: A2BEC9 O95604 Q8IUX9 Q9C018

Alternative splicing: 2 isoforms: Q9C019-1 Q9C019-2

Explore the universe of human proteins at neXtProt for TRIM15: NX_Q9C019

Explore proteomics data for TRIM15 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9C019

TRIM15 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_150232.2

ENSEMBL proteins:

ENSP00000365884 ENSP00000398285 ENSP00000365878

Human Recombinant Protein Products for TRIM15:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for TRIM15 OriGene Protein Over-expression Lysate for TRIM15 OriGene MassSpec for TRIM15 OriGene Custom Protein Services for TRIM15
	GenScript Custom Purified and Recombinant Proteins Services for TRIM15
	Novus Biologicals TRIM15 Protein Novus Biologicals TRIM15 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for TRIM15

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--

TRIM15 for ontologies About GeneDecksing

TRIM15 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for TRIM15
	GenScript Custom Superior Antibodies Services for TRIM15
	Novus Biologicals TRIM15 Antibodies
	Abcam antibodies for TRIM15
	Cloud-Clone Corp. Antibodies for TRIM15
	ThermoFisher Antibodies for TRIM15
	LSBio Antibodies in human, mouse, rat for TRIM15

Assay Products for TRIM15:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for TRIM15
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TRIM15
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for TRIM15 Cloud-Clone Corp. CLIAs for TRIM15

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

TRIM: Tripartite motif containing / Tripartite motif containing

RNF: RING-type (C3HC4) zinc fingers

5/10 InterPro protein domains (see all 10):

IPR006574 PRY

IPR017907 Znf_RING_CS

IPR001841 Znf_RING

IPR001870 B30.2/SPRY

IPR003877 SPRY_rcpt

Graphical View of Domain Structure for InterPro Entry Q9C019

ProtoNet protein and cluster: Q9C019

4 Blocks protein domains:

IPB000315 B-box zinc finger signature

IPB001841 Zn-finger

IPB003879 Butyrophylin C-terminal DUF signature

IPB006574 SPRY-associated domain

UniProtKB/Swiss-Prot: TRI15_HUMAN, Q9C019

Similarity: Belongs to the TRIM/RBCC family

Similarity: Contains 1 B box-type zinc finger

Similarity: Contains 1 B30.2/SPRY domain

Similarity: Contains 1 RING-type zinc finger

TRIM15 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	--	--

TRIM15 for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for TRIM15:

Decreased homologous recombina

Decreased viability with pacli

Increased cell death HMECs cel

Synthetic lethal with c-Myc af

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for TRIM15

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRIM15

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM15

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM15

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM15
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TRIM15
		SwitchGear 3'UTR luciferase reporter plasmid: TRIM15 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for TRIM15
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM15

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TRIM15
			Sirion Biotech Customized adenovirus for overexpression of TRIM15

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for TRIM15 (see all 6) OriGene ORF clones in mouse, rat for TRIM15 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TRIM15 (NM_033229)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM15
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM15
		Sirion Biotech Customized lentivirus for stable overexpression of TRIM15 Customized lentivirus expression plasmids for stable overexpression of TRIM15

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TRIM15
		Search LifeMap BioReagents cell lines for TRIM15

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM15

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TRIM15

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

5/9 Interacting proteins for TRIM15 (Q9C019³ ENSP00000365884⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBE2U	Q5VVX9³	I2D: score=2
EHMT1	Q9H9B1³	I2D: score=1
GTF2E1	P29083³	I2D: score=1
IRF5	Q13568³	I2D: score=1
MED7	O43513³	I2D: score=1

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007500	mesodermal cell fate determination	TAS	10207104

TRIM15 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRIM15 (TRI15)

Search CenterWatch for drugs/clinical trials and news about TRIM15 / TRI15

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRIM15 gene (2 alternative transcripts):

NM_033229.2 NM_052812.1

Unigene Cluster for TRIM15:

Tripartite motif containing 15

Hs.591789 [show with all ESTs]

Unigene Representative Sequence: U34249

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000376694(uc010jrx.3) ENST00000433744 ENST00000477944 ENST00000376688

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM15
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TRIM15
		SwitchGear 3'UTR luciferase reporter plasmid: TRIM15 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for TRIM15
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM15

Clone Products:		OriGene clones in human, mouse for TRIM15 (see all 6) OriGene ORF clones in mouse, rat for TRIM15 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TRIM15 (NM_033229)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM15
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM15
		Sirion Biotech Customized lentivirus for stable overexpression of TRIM15 Customized lentivirus expression plasmids for stable overexpression of TRIM15

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for TRIM15
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TRIM15
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM15
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM15

Additional mRNA sequence:

AF220132.1 AF220133.1 AK290280.1 AK291853.1 BC038585.1 U34249.1

6 DOTS entries:

DT.406377 DT.40233789 DT.75188956 DT.91755436 DT.121346054 DT.75165522

4 AceView cDNA sequences:

AF220132 NM_033229 U34249 BC038585

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRIM15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCCCCTGTGC

About this image

See TRIM15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIM15

SOURCE GeneReport for Unigene cluster: Hs.591789

SABiosciences Expression via Pathway-Focused PCR Array including TRIM15:

Polycomb & Trithorax Target Genes in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for TRIM15
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TRIM15
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM15
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM15

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM15

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TRIM15 gene from 3/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Trim15^{1 , 5}	tripartite motif-containing 15^{1, 5}	78.79(n)¹ 76.22(a)¹		17 (19.16 cM)⁵ 69097¹ NM_001177872.1¹ NP_001171343.1¹ 36860693⁵
chicken (Gallus gallus)	Aves	TRIM7.2⁶ TRIM27.1⁶	tripartite motif-containing 27	29(a) 27(a)	many ↔ many many ↔ many	16(209966-214262) 16(150525-169149)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 31)	Uncharacterized protein (see all 31)	34(a) 33(a) (see all 31)	possible ortholog possible ortholog (see all 31)	2(198879184-198890512) 2(195919842-195929549)

ENSEMBL Gene Tree for TRIM15 (if available)
TreeFam Gene Tree for TRIM15 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TRIM15 gene

TRIM7² TRIM4² TRIM26² TRIM39² TRIM34² TRIM27² TRIM58² TRIM68²

TRIM10² TRIM60² TRIM22² TRIM17² TRIM5² TRIM6² TRIM6-TRIM34² TRIM21²

TRIM38² TRIM11² TRIM39-RPP21²

8 SIMAP similar genes for TRIM15 using alignment to 4 protein entries: TRI15_HUMAN (see all proteins):

ZNFB7 TRIM10 TRIM39R TRIM7 TRIM38 TRIM27

TRIM39 MEFV

TRIM15 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs149524406^1,2	C	--	30130806(+)	`TGGTGA/GGGGAT`	1	--	us2k¹		0	--	--	--	--
rs2517625^1,2	H	--	30130921(-)	`GGACGC/GTGTTT`	1	--	us2k¹		4		NS EA	416
rs17188113^1,2	C,F	--	30131123(+)	`CCTCAT/GGGTGT`	1	--	ut5¹ ese³		3		MN NA EA	336
rs189105911^1,2		--	30131220(+)	`GAGACG/TCCCTG`	1	--	ut5¹		0	--	--	--	--
rs146207681^1,2		--	30131296(+)	`GGTGGA/CTTCCC`	1	--	ut5¹		0	--	--	--	--
rs200720900^1,2	C	--	30131318(+)	`CTTGC-/CTCT CTCTC`	1	--	ut5¹		0	--	--	--	--
rs62407492^1,2	C	--	30131331(+)	`TCTCTC/TTCTCT`	1	--	ut5¹		0	--	--	--	--
rs9261536^1,2	C,F,A,H	--	30131349(+)	`TCTCTC/TAGCCT`	1	--	ut5¹ ese³		29		NS EA NA WA CSA	2781
rs201508191^1,2	C	--	30131468(+)	`TGCCCG/ACAACC`	2	/T /A	mis¹		1		EU	437
rs143628773^1,2	F	--	30131483(+)	`CCCTGA/GAGGTG`	2	K E	mis¹		1		NA	4472

HapMap Linkage Disequilibrium report for TRIM15 (30130983 - 30140473 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for TRIM15: About this table

Variant ID	Type	Subtype	PubMed ID
esv2731777	CNV	Deletion	23290073

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing TRIM15

DNA2.0 Custom Variant and Variant Library Synthesis for TRIM15

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

3 diseases for TRIM15: About MalaCards

hemochromatosis systemic lupus erythematosus lupus erythematosus

TRIM15 for disorders About GeneDecksing

Genetic Association Database (GAD): TRIM15
Human Genome Epidemiology (HuGE) Navigator: TRIM15 (4 documents)

Export disorders for TRIM15 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TRIM15 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with TRIM15)

Utopia: connect your pdf to the dynamic
world of online information

The tripartite motif family identifies cell compartments. (PubMed id 11331580)^{1, 2, 3} Reymond A.... Ballabio A. (2001)
Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection. (PubMed id 8304341)^{1, 2, 3} Goei V.L.... Gruen J.R. (1994)
Refining the association of MHC with multiple scleros is in African Americans. (PubMed id 20466734)^{1, 4} McElroy J.P....Gourraud P.A. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (2010)
High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)^{1, 4} Barcellos L.F....Criswell L.A. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A transcription map of the major histocompatibility c omplex (MHC) class I region. (PubMed id 8812418)^{1, 3} Gruen J.R....Weissman S.M. (1996)
Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)¹ Woodsmith J....Sanderson C.M. (2012)
Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)¹ Lee O.H....Songyang Z. (2011)
An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)¹ Ravasi T....Hayashizaki Y. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 89870	HGNC: 16284	AceView: TRIM15	Ensembl:ENSG00000204610	euGenes: HUgn89870
ECgene: TRIM15	H-InvDB: TRIM15

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TRIM15	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TRIM15 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TRIM15 gene:
Search GeneIP for patents involving TRIM15

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for TRIM15
	Browse OriGene qPCR primer pairs and template standards		OriGene Protein Over-expression Lysate for TRIM15
	OriGene MassSpec something-or-other for TRIM15		OriGene clones in human, mouse for TRIM15
	OriGene qSTAR qPCR primer pairs in human, mouse for TRIM15		OriGene Purified Protein for TRIM15
	OriGene ORF clones in mouse, rat for TRIM15		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TRIM15		OriGene Custom Protein Services for TRIM15

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIM15
	QIAGEN SeqTarget long-range PCR primers for resequencing TRIM15
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM15
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM15
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM15
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM15

	GenScript Custom Purified and Recombinant Proteins Services for TRIM15		GenScript cDNA clones with any tag delivered in your preferred vector for TRIM15
	GenScript Custom Assay Services for TRIM15		GenScript Custom Superior Antibodies Services for TRIM15
	GenScript Custom overexpressing Cell Line Services for TRIM15		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TRIM15 promoter
	Search Chromatin IP Primers for TRIM15
	RT² qPCR Primer Assay in human, mouse, rat TRIM15
	Search GNC Networks for TRIM15
	SABiosciences PCR Arrays including human, mouse, rat TRIM15

Search Tocris compounds for TRIM15 (TRI15)

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TRIM15 antibodies
	TRIM15 proteins
	TRIM15 lysates

	Antibodies for TRIM15
	See all of Abcam's Antibodies, Kits and Proteins for TRIM15
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for TRIM15
	Antibodies for TRIM15
	ELISAs for TRIM15
	CLIAs for TRIM15

Search LifeMap BioReagents cell lines for TRIM15

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM15

	SwitchGear 3'UTR luciferase reporter plasmids for TRIM15
	SwitchGear Promoter luciferase reporter plasmids for TRIM15

ThermoFisher Antibodies for TRIM15

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM15

	inGenious Targeting Laboratory - Custom generated mouse model solutions for TRIM15
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRIM15

Customized:

	lentivirus for stable overexpression of TRIM15
	lentivirus expression plasmids for stable overexpression of TRIM15
	adenovirus for overexpression of TRIM15

LSBio Antibodies in human, mouse, rat for TRIM15

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TRIM15 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

TRIM15 Gene

Tripartite Motif Containing 15

Aliases
for TRIM15 gene

Summaries
for TRIM15 gene

Genomic Views
for TRIM15 gene

Proteins
for TRIM15 gene

Protein Domains /
Families
for TRIM15 gene

Function
for TRIM15 gene

Pathways & Interactions
for TRIM15 gene

Drugs & Compounds
for TRIM15 gene

Transcripts
for TRIM15 gene

Expression
for TRIM15 gene

Orthologs
for TRIM15 gene

Paralogs
for TRIM15 gene

Genomic Variants
for TRIM15 gene

Disorders / Diseases
for TRIM15 gene

Publications
for TRIM15 gene

External Searches for TRIM15 gene

Genome Databases showing TRIM15 gene

Other Databases showing TRIM15 gene

Specialized Databases showing TRIM15 gene

Intellectual Property
for TRIM15 gene

Products
for TRIM15 gene

View Random Gene

Advanced Search

Export list of displayed genes

TRIM15 Gene

Tripartite Motif Containing 15

Aliasesfor TRIM15 gene

Summariesfor TRIM15 gene

Genomic Viewsfor TRIM15 gene

Proteinsfor TRIM15 gene

Protein Domains /Familiesfor TRIM15 gene

Functionfor TRIM15 gene

Pathways & Interactionsfor TRIM15 gene

Drugs & Compoundsfor TRIM15 gene

Transcriptsfor TRIM15 gene

Expression for TRIM15 gene

Orthologsfor TRIM15 gene

Paralogsfor TRIM15 gene

Genomic Variantsfor TRIM15 gene

Disorders / Diseasesfor TRIM15 gene

Publicationsfor TRIM15 gene

External Searches for TRIM15 gene

Genome Databases showing TRIM15 gene

Other Databases showing TRIM15 gene

Specialized Databases showing TRIM15 gene

Intellectual Propertyfor TRIM15 gene

Productsfor TRIM15 gene

View Random Gene

Aliases
for TRIM15 gene

Summaries
for TRIM15 gene

Genomic Views
for TRIM15 gene

Proteins
for TRIM15 gene

Protein Domains /
Families
for TRIM15 gene

Function
for TRIM15 gene

Pathways & Interactions
for TRIM15 gene

Drugs & Compounds
for TRIM15 gene

Transcripts
for TRIM15 gene

Expression
for TRIM15 gene

Orthologs
for TRIM15 gene

Paralogs
for TRIM15 gene

Genomic Variants
for TRIM15 gene

Disorders / Diseases
for TRIM15 gene

Publications
for TRIM15 gene

Intellectual Property
for TRIM15 gene

Products
for TRIM15 gene