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Aliases for TRIM15 Gene

Aliases for TRIM15 Gene

  • Tripartite Motif Containing 15 2 3
  • Zinc Finger Protein 178 2 3 4
  • Tripartite Motif-Containing 15 2 3
  • Zinc Finger Protein B7 3 4
  • RING Finger Protein 93 3 4
  • ZNF178 3 4
  • RNF93 3 4
  • ZNFB7 3 4
  • Tripartite Motif-Containing Protein 15 3

External Ids for TRIM15 Gene

Previous Symbols for TRIM15 Gene

  • ZNF178

Summaries for TRIM15 Gene

Entrez Gene Summary for TRIM15 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM15 Gene

TRIM15 (Tripartite Motif Containing 15) is a Protein Coding gene. An important paralog of this gene is TRIM50.

Gene Wiki entry for TRIM15 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM15 Gene

Genomics for TRIM15 Gene

Genomic Location for TRIM15 Gene

Start:
30,163,191 bp from pter
End:
30,172,696 bp from pter
Size:
9,506 bases
Orientation:
Plus strand

Genomic View for TRIM15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for TRIM15 Gene

Proteins for TRIM15 Gene

  • Protein details for TRIM15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C019-TRI15_HUMAN
    Recommended name:
    Tripartite motif-containing protein 15
    Protein Accession:
    Q9C019
    Secondary Accessions:
    • A2BEC9
    • O95604
    • Q8IUX9
    • Q9C018

    Protein attributes for TRIM15 Gene

    Size:
    465 amino acids
    Molecular mass:
    52113 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIM15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM15 Gene

Proteomics data for TRIM15 Gene at MOPED

Post-translational modifications for TRIM15 Gene

No Post-translational modifications

Other Protein References for TRIM15 Gene

No data available for DME Specific Peptides for TRIM15 Gene

Domains for TRIM15 Gene

Gene Families for TRIM15 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Graphical View of Domain Structure for InterPro Entry

Q9C019

UniProtKB/Swiss-Prot:

TRI15_HUMAN
Domain:
  • Contains 1 B30.2/SPRY domain.:
    • Q9C019
Family:
  • Belongs to the TRIM/RBCC family.:
    • Q9C019
Similarity:
  • Contains 1 B box-type zinc finger.:
    • Q9C019
  • Contains 1 RING-type zinc finger.:
    • Q9C019
genes like me logo Genes that share domains with TRIM15: view

Function for TRIM15 Gene

Gene Ontology (GO) - Molecular Function for TRIM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM15: view
genes like me logo Genes that share phenotypes with TRIM15: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRIM15 Gene

Localization for TRIM15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM15 Gene COMPARTMENTS Subcellular localization image for TRIM15 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM15 Gene

Pathways for TRIM15 Gene

SuperPathways for TRIM15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007500 mesodermal cell fate determination TAS 10207104
GO:0032481 positive regulation of type I interferon production IMP 23077300
GO:0045087 innate immune response IMP 18248090
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IMP 23077300
GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA 23077300
genes like me logo Genes that share ontologies with TRIM15: view

No data available for Pathways by source for TRIM15 Gene

Transcripts for TRIM15 Gene

mRNA/cDNA for TRIM15 Gene

(16) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM15 Gene

Tripartite motif containing 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM15 Gene

No ASD Table

Relevant External Links for TRIM15 Gene

GeneLoc Exon Structure for
TRIM15
ECgene alternative splicing isoforms for
TRIM15

Expression for TRIM15 Gene

mRNA expression in normal human tissues for TRIM15 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM15 Gene

This gene is overexpressed in Colon - Transverse (18.0), Liver (16.0), Small Intestine - Terminal Ileum (10.5), and Kidney - Cortex (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRIM15 Gene

SOURCE GeneReport for Unigene cluster for TRIM15 Gene Hs.591789

genes like me logo Genes that share expressions with TRIM15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TRIM15 Gene

Orthologs for TRIM15 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM15 35
  • 99.07 (n)
  • 98.71 (a)
TRIM15 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM15 35
  • 86.98 (n)
  • 84.82 (a)
TRIM15 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim15 35
  • 78.75 (n)
  • 76.31 (a)
Trim15 16
Trim15 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM15 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM15 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910806 35
  • 79.6 (n)
  • 77.27 (a)
Species with no ortholog for TRIM15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM15 Gene

ENSEMBL:
Gene Tree for TRIM15 (if available)
TreeFam:
Gene Tree for TRIM15 (if available)

Paralogs for TRIM15 Gene

Selected SIMAP similar genes for TRIM15 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TRIM15: view

Variants for TRIM15 Gene

Sequence variations from dbSNP and Humsavar for TRIM15 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs929156 - 30,171,922(-) GCAGG(C/T)TCTTC missense, reference
rs929157 -- 30,169,432(-) TAGAA(C/T)GCAAA intron-variant
rs1008403 -- 30,165,050(-) GAGGA(A/G)GGGAG intron-variant
rs1018846 -- 30,169,872(-) CTGCA(C/T)GGGAA intron-variant
rs1029237 -- 30,170,885(-) GTGAA(A/G)ATGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM15 Gene

Variant ID Type Subtype PubMed ID
esv2731777 CNV Deletion 23290073

Relevant External Links for TRIM15 Gene

HapMap Linkage Disequilibrium report
TRIM15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM15 Gene

Disorders for TRIM15 Gene

Relevant External Links for TRIM15

Genetic Association Database (GAD)
TRIM15
Human Genome Epidemiology (HuGE) Navigator
TRIM15
genes like me logo Genes that share disorders with TRIM15: view

No data available for UniProtKB/Swiss-Prot for TRIM15 Gene

Publications for TRIM15 Gene

  1. Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection. (PMID: 8304341) Goei V.L. … Gruen J.R. (Am. J. Hum. Genet. 1994) 2 3 4
  2. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3 4
  3. A transcription map of the major histocompatibility complex (MHC) class I region. (PMID: 8812418) Gruen J.R. … Weissman S.M. (Genomics 1996) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for TRIM15 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Polycomb & Trithorax Target Genes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TRIM15
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM15
    • Block miRNA regulation of TRIM15 using miScript Target Protectors

    Sources for TRIM15 Gene

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