Aliases for TRIM15 Gene
Aliases for TRIM15 Gene
External Ids for TRIM15 Gene
- HGNC: 16284
- Entrez Gene: 89870
- Ensembl: ENSG00000204610
- UniProtKB: Q9C019
Previous HGNC Symbols for TRIM15 Gene
- ZNF178
Previous GeneCards Identifiers for TRIM15 Gene
- GC06P030215
- GC06P029901
- GC06P030237
- GC06P030238
- GC06P030130
- GC06P029929
- GC06P030282
- GC06P030318
- GC06P030368
- GC06P030518
- GC06P030727
- GC06P030884
- GC06P031042
Summaries for TRIM15 Gene
-
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRIM15 Gene
TRIM15 (Tripartite Motif Containing 15) is a Protein Coding gene. An important paralog of this gene is TRIM10.
Additional gene information for TRIM15 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM15 Gene
Genomics for TRIM15 Gene
GeneHancer (GH) Regulatory Elements for TRIM15 Gene
Regulatory Element Products
Genomic Locations for TRIM15 Gene
- chr6:30,163,206-30,172,696
- (GRCh38/hg38)
- Size:
- 9,491 bases
- Orientation:
- Plus strand
- chr6:30,130,983-30,140,473
- (GRCh37/hg19)
Genomic View for TRIM15 Gene
- Cytogenetic band:
-
- 6p22.1 by Ensembl
- 6p22.1 by Entrez Gene
- 6p22.1 by HGNC


RefSeq DNA sequence for TRIM15 Gene
Proteins for TRIM15 Gene
-
Protein details for TRIM15 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9C019-TRI15_HUMAN
- Recommended name:
- Tripartite motif-containing protein 15
- Protein Accession:
- Q9C019
- A2BEC9
- O95604
- Q8IUX9
- Q9C018
Protein attributes for TRIM15 Gene
- Size:
- 465 amino acids
- Molecular mass:
- 52113 Da
- Quaternary structure:
- No Data Available
Protein Expression for TRIM15 Gene
Post-translational modifications for TRIM15 Gene
Other Protein References for TRIM15 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for TRIM15
-
Abcam antibodies for TRIM15
- Invitrogen Antibodies for TRIM15
- GeneTex TRIM15 antibody for TRIM15
Protein Products
-
OriGene Purified Proteins for TRIM15
- Search Origene for MassSpec and Protein Over-expression Lysates for TRIM15
- Origene Custom Protein Services for TRIM15
- antibodies-online: Search results for 5 available TRIM15 Proteins ranked by validation data
- Compare Top TRIM15 Proteins
-
Quality Products:
- Search GeneTex for Proteins for TRIM15
-
Abcam proteins for TRIM15
Assay Products
No data available for DME Specific Peptides for TRIM15 Gene
Domains & Families for TRIM15 Gene
Gene Families for TRIM15 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TRIM15 Gene
Suggested Antigen Peptide Sequences for TRIM15 Gene
Graphical View of Domain Structure for InterPro Entry
Q9C019- Family:
-
- Belongs to the TRIM/RBCC family.
Function for TRIM15 Gene
Phenotypes From GWAS Catalog for TRIM15 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 25416956 |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for TRIM15 Gene
- GenomeRNAi human phenotypes for TRIM15:
-
- Increased vaccinia virus (VACV) infection
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased viability with paclitaxel
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased cell death HMECs cells
- Decreased homologous recombination repair frequency
- Negative genetic interaction between BLM-/- and BLM+/+
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TRIM15
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TRIM15 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TRIM15 gene
- Search ViGene Biosciences for TRIM15
CRISPR Products
-
OriGene CRISPR knockouts for TRIM15
- genomics-online: gRNA clones - Search results for 64 available TRIM15 gene related products
- Overview of 64 available TRIM15 gene related products
- Applied Biological Materials CRISPR for TRIM15
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM15
- GenScript: Design CRISPR guide RNA sequences for TRIM15
miRNA Products
- Search ViGene Biosciences for TRIM15
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for TRIM15
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- genomics-online: shRNA clones - Search results for 64 available TRIM15 gene related products
- Overview of 64 available TRIM15 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TRIM15 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TRIM15
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRIM15
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TRIM15
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TRIM15
-
ViGene Biosciences adenoviral particle packaged cDNA for TRIM15 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TRIM15 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TRIM15 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM15 Gene
Localization for TRIM15 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005622 | intracellular | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TRIM15 Gene
Pathways & Interactions for TRIM15 Gene
Interacting Proteins for TRIM15 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007500 | mesodermal cell fate determination | TAS | 10207104 |
GO:0032481 | positive regulation of type I interferon production | IMP | 23077300 |
GO:0045087 | innate immune response | IMP | 18248090 |
GO:0051091 | positive regulation of DNA binding transcription factor activity | IMP | 23077300 |
GO:0051092 | positive regulation of NF-kappaB transcription factor activity | IDA | 23077300 |
No data available for Pathways by source and SIGNOR curated interactions for TRIM15 Gene
Transcripts for TRIM15 Gene
mRNA/cDNA for TRIM15 Gene
- (4) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (4) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TRIM15 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TRIM15
- genomics-online: gRNA clones - Search results for 64 available TRIM15 gene related products
- Overview of 64 available TRIM15 gene related products
- Applied Biological Materials CRISPR for TRIM15
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM15
- GenScript: Design CRISPR guide RNA sequences for TRIM15
miRNA Products
- Search ViGene Biosciences for TRIM15
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for TRIM15
- Browse OriGene Inhibitory RNA Products For TRIM15
- genomics-online: shRNA clones - Search results for 64 available TRIM15 gene related products
- Overview of 64 available TRIM15 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TRIM15 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TRIM15
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRIM15
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TRIM15
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TRIM15 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for TRIM15 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM15 Gene
NURSA nuclear receptor signaling pathways regulating expression of TRIM15 Gene:
TRIM15SOURCE GeneReport for Unigene cluster for TRIM15 Gene:
Hs.591789Evidence on tissue expression from TISSUES for TRIM15 Gene
- Intestine(4.3)
Primer Products
-
OriGene qPCR primer pairs for TRIM15
- genomics-online: primer clones - Search results for 64 available TRIM15 gene related products
- Overview of 64 available TRIM15 gene related products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM15 Gene
Orthologs for TRIM15 Gene
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | TRIM15 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | TRIM15 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | LOC100910806 33 |
|
||
mouse (Mus musculus) |
Mammalia | Trim15 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | TRIM15 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | TRIM15 34 |
|
OneToOne |
- Species where no ortholog for TRIM15 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TRIM15 Gene
Paralogs for TRIM15 Gene
(8) SIMAP similar genes for TRIM15 Gene using alignment to 4 proteins:
Variants for TRIM15 Gene
SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000193870 | -- | 30,166,777(+) | C/T | intron_variant | |
rs1000368816 | -- | 30,173,109(+) | G/A | downstream_transcript_variant | |
rs1000439832 | -- | 30,169,245(+) | T/A | coding_sequence_variant, missense_variant | |
rs1000698966 | -- | 30,171,701(+) | C/A | intron_variant | |
rs1000806121 | -- | 30,164,911(+) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2731777 | CNV | deletion | 23290073 |
esv3411275 | CNV | duplication | 20981092 |
nsv1074389 | CNV | deletion | 25765185 |
nsv1122126 | CNV | deletion | 24896259 |
nsv1144137 | CNV | deletion | 24896259 |
nsv601264 | CNV | loss | 21841781 |
Additional Variant Information for TRIM15 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TRIM15
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM15 Gene
Disorders for TRIM15 Gene
Additional Disease Information for TRIM15
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for TRIM15 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM15 Gene
Publications for TRIM15 Gene
- The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A … Ballabio A (The EMBO journal 2001) 2 3 4 58
- Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection. (PMID: 8304341) Goei VL … Gruen JR (American journal of human genetics 1994) 2 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Refining the association of MHC with multiple sclerosis in African Americans. (PMID: 20466734) McElroy JP … Gourraud PA (Human molecular genetics 2010) 3 44 58
- High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
Products for TRIM15 Gene
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- Invitrogen Antibodies for TRIM15
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- VectorBuilder custom plasmid, inducible vectors for TRIM15
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRIM15
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 50 available TRIM15 Antibodies ranked by validation data
- Compare Top TRIM15 Antibodies
- antibodies-online: Search results for available TRIM15 related products ranked by validation data
- antibodies-online: Search results for 5 available TRIM15 Proteins ranked by validation data
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- Quality Products:
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- ViGene Biosciences adenoviral particle packaged cDNA for TRIM15 gene
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- genomics-online: cdna clones - Search results for 64 available TRIM15 gene related products
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- Overview of 64 available TRIM15 gene related products
- genomics-online: shRNA clones - Search results for 64 available TRIM15 gene related products
- Overview of 64 available TRIM15 gene related products
Sources for TRIM15 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
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- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
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- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew