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TRIM15 Gene(Protein Coding)

Tripartite Motif Containing 15

GCID:
GC06P030368
GIFtS:
50
Genes Participants
UDN Logo

Aliases for TRIM15 Gene

Aliases for TRIM15 Gene

  • Tripartite Motif Containing 15 2 3 5
  • Zinc Finger Protein 178 2 3 4
  • Tripartite Motif-Containing 15 2 3
  • Zinc Finger Protein B7 3 4
  • RING Finger Protein 93 3 4
  • ZNF178 3 4
  • RNF93 3 4
  • ZNFB7 3 4

External Ids for TRIM15 Gene

Previous HGNC Symbols for TRIM15 Gene

  • ZNF178

Previous GeneCards Identifiers for TRIM15 Gene

  • GC06P030215
  • GC06P029901
  • GC06P030237
  • GC06P030238
  • GC06P030130
  • GC06P029929
  • GC06P030282
  • GC06P030318

Summaries for TRIM15 Gene

Entrez Gene Summary for TRIM15 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM15 Gene

TRIM15 (Tripartite Motif Containing 15) is a Protein Coding gene. An important paralog of this gene is TRIM58.

Gene Wiki entry for TRIM15 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM15 Gene

Genomics for TRIM15 Gene

Products:

  1. Regulatory Element

Regulatory Elements for TRIM15 Gene

Enhancers for TRIM15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM15 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM15 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TRIM15 gene promoter:

Genomic Location for TRIM15 Gene

Chromosome:
6
Start:
30,163,206 bp from pter
End:
30,172,696 bp from pter
Size:
9,491 bases
Orientation:
Plus strand

Genomic View for TRIM15 Gene

Genes around TRIM15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM15 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TRIM15 Gene

Proteins for TRIM15 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TRIM15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C019-TRI15_HUMAN
    Recommended name:
    Tripartite motif-containing protein 15
    Protein Accession:
    Q9C019
    Secondary Accessions:
    • A2BEC9
    • O95604
    • Q8IUX9
    • Q9C018

    Protein attributes for TRIM15 Gene

    Size:
    465 amino acids
    Molecular mass:
    52113 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIM15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM15 Gene

Proteomics data for TRIM15 Gene at MOPED

Protein Expression for TRIM15 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TRIM15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM15 Gene

Domains & Families for TRIM15 Gene

Gene Families for TRIM15 Gene

HGNC:

Protein Domains for TRIM15 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TRIM15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C019

UniProtKB/Swiss-Prot:

TRI15_HUMAN :
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Domain:
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM15: view

Function for TRIM15 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Phenotypes for TRIM15 Gene

GenomeRNAi human phenotypes for TRIM15:
genes like me logo Genes that share phenotypes with TRIM15: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM15 Gene

Localization for TRIM15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM15 Gene COMPARTMENTS Subcellular localization image for TRIM15 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIM15 Gene

Pathways & Interactions for TRIM15 Gene

SuperPathways for TRIM15 Gene

PathCards logoMore details on SuperPathways for TRIM15
No Data Available

Gene Ontology (GO) - Biological Process for TRIM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032481 positive regulation of type I interferon production IMP 23077300
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IMP 23077300
GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA 23077300
GO:1900246 positive regulation of RIG-I signaling pathway IMP 23077300
genes like me logo Genes that share ontologies with TRIM15: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM15 Gene

Drugs & Compounds for TRIM15 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for TRIM15 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for TRIM15 Gene

(16) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM15 Gene

Tripartite motif containing 15:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM15 Gene

No ASD Table

Relevant External Links for TRIM15 Gene

GeneLoc Exon Structure for
TRIM15
ECgene alternative splicing isoforms for
TRIM15

Expression for TRIM15 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for TRIM15 Gene

mRNA expression in normal human tissues for TRIM15 Gene
mRNA expression by BioGPS for TRIM15 GenemRNA expression by GTEx for TRIM15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM15 Gene

This gene is overexpressed in Colon - Transverse (x18.0), Liver (x16.0), Small Intestine - Terminal Ileum (x10.5), and Kidney - Cortex (x5.6).

Protein differential expression in normal tissues from HIPED for TRIM15 Gene

This gene is overexpressed in Oral epithelium (28.4), Kidney (25.3), and Ovary (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM15 Gene



SOURCE GeneReport for Unigene cluster for TRIM15 Gene Hs.591789

genes like me logo Genes that share expression patterns with TRIM15: view

Protein tissue co-expression partners for TRIM15 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TRIM15 Gene

Orthologs for TRIM15 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia TRIM15 35
  • 86.98 (n)
  • 84.82 (a)
TRIM15 36
  • 88 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Trim15 35
  • 78.75 (n)
  • 76.31 (a)
Trim15 16
Trim15 36
  • 74 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia TRIM15 35
  • 99.07 (n)
  • 98.71 (a)
TRIM15 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia LOC100910806 35
  • 79.6 (n)
  • 77.27 (a)
oppossum
(Monodelphis domestica)
 Mammalia TRIM15 36
  • 63 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia TRIM15 36
  • 53 (a)
 OneToOne
Species with no ortholog for TRIM15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM15 Gene

ENSEMBL:
Gene Tree for TRIM15 (if available)
TreeFam:
Gene Tree for TRIM15 (if available)

Paralogs for TRIM15 Gene

Paralogs for TRIM15 Gene

(8) SIMAP similar genes for TRIM15 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TRIM15: view

Variants for TRIM15 Gene

Sequence variations from dbSNP and Humsavar for TRIM15 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_014228 -
VAR_052129 -
VAR_052130 -
rs34823152 - 30,168,525(+) AGCTT(C/G)TACAA intron-variant, reference, missense
rs929156 - 30,171,922(-) GCAGG(C/T)TCTTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TRIM15 Gene

Variant ID Type Subtype PubMed ID
esv2731777 CNV Deletion 23290073

Variation tolerance for TRIM15 Gene

Residual Variation Intolerance Score: 84.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.63; 82.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRIM15 Gene

Disorders for TRIM15 Gene

Relevant External Links for TRIM15

Genetic Association Database (GAD)
TRIM15
Human Genome Epidemiology (HuGE) Navigator
TRIM15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM15

No disorders were found for TRIM15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM15 Gene

Publications for TRIM15 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3 4 67
  2. A transcription map of the major histocompatibility complex (MHC) class I region. (PMID: 8812418) Gruen J.R. … Weissman S.M. (Genomics 1996) 2 3
  3. Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection. (PMID: 8304341) Goei V.L. … Gruen J.R. (Am. J. Hum. Genet. 1994) 2 3
  4. Role of the focal adhesion protein TRIM15 in colon cancer development. (PMID: 25450970) Lee O.H. … Choi Y. (Biochim. Biophys. Acta 2015) 3
  5. Genome-wide association study of proneness to anger. (PMID: 24489884) Mick E. … Goldberg R.J. (PLoS ONE 2014) 3

Products for TRIM15 Gene

Sources for TRIM15 Gene

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