TRIM15 Gene
protein-coding GIFtS: 47
GCID: GC06P030130
|
|
tripartite motif containing 15(Previous names: zinc finger protein 178, tripartite motif-containing 15...)
(Previous symbol: ZNF178)
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Aliases
for TRIM15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tripartite Motif Containing 151 2 | | Tripartite Motif-Containing 151 2 | | Zinc Finger Protein 1781 2 3 | | Zinc Finger Protein B72 3 | | RNF931 2 3 | | RING Finger Protein 932 3 | | ZNF1781 2 3 | | Tripartite Motif-Containing Protein 152 | | ZNFB71 2 3 | | |
Export aliases for TRIM15 gene to outside databasesPrevious GC identifers: GC06P030215 GC06P029901 GC06P030237 GC06P030238 GC06P029929 |
Summaries
for TRIM15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TRIM15:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes tothe cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has notbeen determined. (provided by RefSeq, Jul 2008)
Gene Wiki entry for TRIM15
|
Genomic Views
for TRIM15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167246.1 NT_167247.1
- NT_167248.1 NT_167249.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRIM15 gene promoter:
Max1 AML1a MyoD Nkx2-5 c-Ets-1 Arnt MZF-1 E2F-1 E2F
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIM15
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM15 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p22.1 HGNC cytogenetic band: 6p21.33TRIM15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P030130: view genomic region
(about GC identifiers)
Start:
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30,130,983 bp from pter |
End:
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30,140,473 bp from pter |
Size:
|
9,491 bases |
Orientation:
|
plus strand |
6/7 alternative locations (see all 7):
| Chr6+,ALT_REF_LOCI_2 30,120,906-30,169,584 | Chr6+,ALT_REF_LOCI_3 30,121,295-30,141,823 | Chr6+,ALT_REF_LOCI_5 30,124,287-30,133,777 | | Chr6+,ALT_REF_LOCI_6 30,120,533-30,165,604 | Chr6+,ALT_REF_LOCI_4 30,099,187-30,108,677 | Chr6+,ALT_REF_LOCI_1 30,067,805-30,085,595 | |
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Proteins
for TRIM15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRI15_HUMAN, Q9C019 (See
protein sequence)Recommended Name: Tripartite motif-containing protein 15 Size: 465 amino acids; 52113 Da
Secondary accessions: A2BEC9 O95604 Q8IUX9 Q9C018Alternative splicing: 2 isoforms: Q9C019-1 Q9C019-2 Explore the universe of human proteins at neXtProt for TRIM15: NX_Q9C019
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9C019
TRIM15 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_150232.2
ENSEMBL proteins: ENSP00000365884 ENSP00000398285 ENSP00000365878
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
TRIM15 for ontologies About GeneDecksing
TRIM15 Antibody Products:
Assay Products for TRIM15: |
Protein
Domains /
Families
for TRIM15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIM15 for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry Q9C019ProtoNet protein and cluster: Q9C019 4 Blocks protein families: IPB000315 B-box zinc finger signature IPB001841 Zn-finger IPB003879 Butyrophylin C-terminal DUF signature IPB006574 SPRY-associated domain
UniProtKB/Swiss-Prot: TRI15_HUMAN, Q9C019Similarity: Belongs to the TRIM/RBCC familySimilarity: Contains 1 B box-type zinc fingerSimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 RING-type zinc finger |
Function
for TRIM15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM15
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Synthesis Service for TRIM15 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM15 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM15 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
TRIM15 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for TRIM15:
|
Pathways & Interactions
for TRIM15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM15
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/9 Interacting proteins for TRIM15 (Q9C0193 ENSP000003658844) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007500 | mesodermal cell fate determination |
TAS | 10207104 |
TRIM15 for ontologies About GeneDecksing
|
Drugs & Compounds
for TRIM15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRIM15
Search CenterWatch for drugs/clinical trials and news about TRIM15 / TRI15
|
Transcripts
for TRIM15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRIM15 gene (2 alternative transcripts): NM_033229.2 NM_052812.1 Unigene Cluster for TRIM15: Tripartite motif containing 15 Hs.591789 [show with all ESTs]Unigene Representative Sequence: U342495 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000376694(uc010jrx.3) ENST00000433744 ENST00000498045 ENST00000477944
ENST00000376688
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM15
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRIM15 (NM_033229) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM15 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM15 |
Additional cDNA sequence: AF220132.1 AF220133.1 AK290280.1 AK291853.1 BC038585.1 U34249.1 6 DOTS entries: DT.406377 DT.40233789 DT.75188956 DT.91755436 DT.121346054 DT.75165522 4 AceView cDNA sequences: AF220132 U34249 NM_033229 BC038585
GeneLoc Exon Structure
|
Expression
for TRIM15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRIM15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCCTGTGC
About this image
See TRIM15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIM15
SOURCE GeneReport for Unigene cluster: Hs.591789
SABiosciences Expression via Pathway-Focused PCR Array including TRIM15: | Polycomb & Trithorax Target Genes in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM15
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIM15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM15 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM15 |
Orthologs
for TRIM15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TRIM15 gene from 1/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
trim476 |
tripartite motif containing 47 |
22(a) |
possible ortholog |
10(26752552-26762609) |
ENSEMBL Gene Tree for TRIM15 (if available)
TreeFam Gene Tree for TRIM15 (if available) |
Paralogs
for TRIM15 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRIM15 gene
- TRIM42 TRIM72 TRIM262 TRIM392 TRIM342 TRIML12 TRIM272 TRIM582
- TRIM682 TRIM102 TRIM602 TRIM222 TRIM172 TRIM52 TRIM62 TRIM6-TRIM342
- TRIM212 TRIM382 TRIM39-RPP212 TRIM112
14 SIMAP similar genes for TRIM15 using alignment to 6 protein entries: TRI15_HUMAN (see all proteins):ZNFB7 TRIM10 TRIM39R TRIM27 TRIM7 BT3.3
TRIM38 TRIM39 MEFV TRIM69 TRIM26 TRIM21
TRIM41 TRIM6
TRIM15 for paralogs About GeneDecksing
|
Genomic Variants
for TRIM15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRIM15 (30130983 - 30140473 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TRIM15: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM15 |
|
Disorders
/ Diseases
for TRIM15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRIM15 for disorders About GeneDecksing
4  diseases for TRIM15: About MalaCardssystemic lupus erythematosus lupus erythematosus hemochromatosis hematopoiesis
Human Genome Epidemiology (HuGE) Navigator: TRIM15 (4 documents)
Export disorders for TRIM15 gene to outside databases
|
Publications
for TRIM15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRIM15 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with TRIM15) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2, 3 Reymond A.... Ballabio A. (2001)
- Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection. (PubMed id 8304341)1, 2, 3 Goei V.L.... Gruen J.R. (1994)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A transcription map of the major histocompatibility c omplex (MHC) class I region. (PubMed id 8812418)1, 3 Gruen J.R....Weissman S.M. (1996)
- Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Refining the association of MHC with multiple scleros is in African Americans. (PubMed id 20466734)1 McElroy J.P....Gourraud P.A. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
|
External Searches for TRIM15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TRIM15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRIM15 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRIM15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TRIM15 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TRIM15 gene:
Search GeneIP for patents involving TRIM15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRIM15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TRIM15 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM15 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM15 | | | OriGene Protein Over-expression Lysate for TRIM15 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRIM15 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM15 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM15 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TRIM15 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIM15 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM15 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM15 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM15 |
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 | | | TRIM15 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM15 |
|  |  |  | | | | Search ThermoFisher Antibodies for TRIM15 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM15 |
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