TRIM15 Gene

Aliases
for TRIM15 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC06P030215 GC06P029901 GC06P030237 GC06P030238 GC06P029929

Summaries
for TRIM15 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for TRIM15 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000006.11  NT_007592.16  NT_113891.3  NT_167244.2  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  

NT_167249.2  NC_018917.2  

SwitchGear Promoter luciferase reporter plasmids (see all 2): TRIM15 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM15

TRIM15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P030130:  view genomic region     (about GC identifiers)

Proteins
for TRIM15 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for TRIM15: NX_Q9C019

Explore proteomics data for TRIM15 at MOPED


See TRIM15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

TRIM15 Human Recombinant Protein Products:

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	antibodies-online peptides for TRIM15

TRIM15 Antibody Products:

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TRIM15 Assay Products:

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	antibodies-online kits for TRIM15 (5 products)

Domains /
Families
for TRIM15 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9C019

Find genes that share domains with TRIM15           About GenesLikeMe

Function
for TRIM15 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for TRIM15

miRNA Products:		Block miRNA regulation of human, mouse, rat TRIM15 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate TRIM15
		SwitchGear 3'UTR luciferase reporter plasmid: TRIM15 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TRIM15
		Predesigned siRNA for gene silencing in human, mouse, rat TRIM15

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TRIM15

Clone Products:		OriGene clones in human, mouse for TRIM15 (see all 5) OriGene ORF clones in mouse, rat for TRIM15 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TRIM15 (NM_033229)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM15
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM15

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TRIM15
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM15

Localization
for TRIM15 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	3
cytosol	2

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for TRIM15 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

Drugs & Compounds
for TRIM15 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for TRIM15 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for TRIM15 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TRIM15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCCCCTGTGC

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for TRIM15
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM15
		QuantiTect SYBR Green Assays in human, mouse, rat TRIM15
		QuantiFast Probe-based Assays in human, mouse, rat TRIM15

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM15

Orthologs
for TRIM15 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for TRIM15 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for TRIM15 gene

TRIM31²  TRIM50²  TRIM10²  TRIM73²  TRIM69²  TRIM26²  TRIM74²  TRIM35²  

TRIM52²  TRIM62²  TRIM41²  TRIM72²  

8 SIMAP similar genes for TRIM15 using alignment to 4 protein entries:     TRI15_HUMAN (see all proteins):

ZNFB7    TRIM10    TRIM39R    TRIM7    TRIM38    TRIM27

TRIM39    MEFV

Find genes that share paralogs with TRIM15           About GenesLikeMe

Genomic Variants
for TRIM15 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TRIM15 (see all 288)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1495244061,2	C	--	30130806(+)	TGGTGA/GGGGAT	1	--	us2k1		0	--	--	--	--
rs25176251,2	H	--	30130921(-)	GGACGC/GTGTTT	1	--	us2k1		4		NS EA	416
rs171881131,2	C,F	--	30131123(+)	CCTCAT/GGGTGT	1	--	ut51 ese3		3		MN NA EA	336
rs1891059111,2		--	30131220(+)	GAGACG/TCCCTG	1	--	ut51		0	--	--	--	--
rs1462076811,2		--	30131296(+)	GGTGGA/CTTCCC	1	--	ut51		0	--	--	--	--
rs2007209001,2	C	--	30131318(+)	CTTGC-/CTCT           CTCTC	1	--	ut51		0	--	--	--	--
rs624074921,2	C	--	30131331(+)	TCTCTC/TTCTCT	1	--	ut51		0	--	--	--	--
rs92615361,2	C,F,A,H	--	30131349(+)	TCTCTC/TAGCCT	1	--	ut51 ese3		29		NS EA NA WA CSA	2781
rs2015081911,2	C	--	30131468(+)	TGCCCG/ACAACC	2	/T /A	mis1		1		EU	437
rs1436287731,2	F	--	30131483(+)	CCCTGA/GAGGTG	2	K E	mis1		1		NA	4472

HapMap Linkage Disequilibrium report for TRIM15 (30130983 - 30140473 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for TRIM15:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2731777	CNV	Deletion	23290073

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TRIM15

DNA2.0 Custom Variant and Variant Library Synthesis for TRIM15

Disorders / Diseases
for TRIM15 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for TRIM15 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TRIM15 gene, integrated from 10 sources (see all 19): (articles sorted by number of sources associating them with TRIM15)

Utopia: connect your pdf to the dynamic world of online information

1. The tripartite motif family identifies cell compartments. (PubMed id 11331580)^{1, 2, 3} Reymond A.... Ballabio A. (EMBO J. 2001)
2. Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection. (PubMed id 8304341)^{1, 2, 3} Goei V.L.... Gruen J.R. (Am. J. Hum. Genet. 1994)
3. Refining the association of MHC with multiple sclerosis in African Americans. (PubMed id 20466734)^{1, 4} McElroy J.P....Gourraud P.A. (Hum. Mol. Genet. 2010)
4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)^{1, 4} Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
7. A transcription map of the major histocompatibility complex (MHC) class I region. (PubMed id 8812418)^{1, 3} Gruen J.R....Weissman S.M. (Genomics 1996)
8. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)¹ Woodsmith J....Sanderson C.M. (amp 2012)
9. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)¹ Lee O.H....Songyang Z. (amp 2011)
10. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)¹ Ravasi T....Hayashizaki Y. (Cell 2010)

External Searches for TRIM15 gene

Genome Databases showing TRIM15 gene

Other Databases showing TRIM15 gene

Specialized Databases showing TRIM15 gene

Products
for TRIM15 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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