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Aliases for TRIM14 Gene

Aliases for TRIM14 Gene

  • Tripartite Motif Containing 14 2 3 5
  • Tripartite Motif-Containing 14 2
  • KIAA0129 4

External Ids for TRIM14 Gene

Previous GeneCards Identifiers for TRIM14 Gene

  • GC09M091671
  • GC09M092581
  • GC09M094304
  • GC09M096226
  • GC09M096211
  • GC09M097926
  • GC09M099871
  • GC09M100831
  • GC09M070431

Summaries for TRIM14 Gene

Entrez Gene Summary for TRIM14 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for TRIM14 Gene

TRIM14 (Tripartite Motif Containing 14) is a Protein Coding gene. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Immune System. An important paralog of this gene is BSPRY.

UniProtKB/Swiss-Prot for TRIM14 Gene

  • Inhibits the transcriptional activity of SPI1 in a dose-dependent manner.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM14 Gene

Genomics for TRIM14 Gene

Regulatory Elements for TRIM14 Gene

Enhancers for TRIM14 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM14 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM14 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM14 Gene

Chromosome:
9
Start:
98,069,275 bp from pter
End:
98,119,408 bp from pter
Size:
50,134 bases
Orientation:
Minus strand

Genomic View for TRIM14 Gene

Genes around TRIM14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM14 Gene

Proteins for TRIM14 Gene

  • Protein details for TRIM14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14142-TRI14_HUMAN
    Recommended name:
    Tripartite motif-containing protein 14
    Protein Accession:
    Q14142
    Secondary Accessions:
    • A8K9W0
    • E7EQC4
    • F8W956
    • Q548W9
    • Q5TBQ8
    • Q6ZWL7
    • Q9BRD8
    • Q9C020

    Protein attributes for TRIM14 Gene

    Size:
    442 amino acids
    Molecular mass:
    49773 Da
    Quaternary structure:
    • Interacts with SPI1.

    Alternative splice isoforms for TRIM14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM14 Gene

Proteomics data for TRIM14 Gene at MOPED

Post-translational modifications for TRIM14 Gene

  • Ubiquitination at Lys 77
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM14 Gene

No data available for DME Specific Peptides for TRIM14 Gene

Domains & Families for TRIM14 Gene

Gene Families for TRIM14 Gene

Suggested Antigen Peptide Sequences for TRIM14 Gene

Graphical View of Domain Structure for InterPro Entry

Q14142

UniProtKB/Swiss-Prot:

TRI14_HUMAN :
  • The B-box zinc finger is responsible for inhibition of SPI1-mediated transcriptional activation.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Domain:
  • The B-box zinc finger is responsible for inhibition of SPI1-mediated transcriptional activation.
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
genes like me logo Genes that share domains with TRIM14: view

Function for TRIM14 Gene

Molecular function for TRIM14 Gene

UniProtKB/Swiss-Prot Function:
Inhibits the transcriptional activity of SPI1 in a dose-dependent manner.
UniProtKB/Swiss-Prot Induction:
By interferons alpha and gamma.
genes like me logo Genes that share phenotypes with TRIM14: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM14 Gene

Localization for TRIM14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM14 Gene COMPARTMENTS Subcellular localization image for TRIM14 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIM14 Gene

Pathways & Interactions for TRIM14 Gene

genes like me logo Genes that share pathways with TRIM14: view

Pathways by source for TRIM14 Gene

Interacting Proteins for TRIM14 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000343990%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000356480%0d%0a9606.ENSP00000368552%0d%0a
Selected Interacting proteins: ENSP00000343990 Q14142-TRI14_HUMAN for TRIM14 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TRIM14 Gene

None

No data available for SIGNOR curated interactions for TRIM14 Gene

Drugs & Compounds for TRIM14 Gene

No Compound Related Data Available

Transcripts for TRIM14 Gene

Unigene Clusters for TRIM14 Gene

Tripartite motif containing 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM14 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10
SP1: - - - - - -
SP2: - - - - -
SP3: -
SP4: - - - - - - - -
SP5: - -
SP6: - - -
SP7: - -
SP8:

Relevant External Links for TRIM14 Gene

GeneLoc Exon Structure for
TRIM14
ECgene alternative splicing isoforms for
TRIM14

Expression for TRIM14 Gene

mRNA expression in normal human tissues for TRIM14 Gene

Protein differential expression in normal tissues from HIPED for TRIM14 Gene

This gene is overexpressed in Heart (26.9), CD8 Tcells (17.9), and Monocytes (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM14 Gene



SOURCE GeneReport for Unigene cluster for TRIM14 Gene Hs.575631

mRNA Expression by UniProt/SwissProt for TRIM14 Gene

Q14142-TRI14_HUMAN
Tissue specificity: Highest expression in liver; undetectable in skeletal muscle.
genes like me logo Genes that share expression patterns with TRIM14: view

Protein tissue co-expression partners for TRIM14 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRIM14 Gene

Orthologs for TRIM14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIM14 35
  • 84.49 (n)
  • 80.58 (a)
TRIM14 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM14 35
  • 86.88 (n)
  • 81.45 (a)
TRIM14 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim14 35
  • 81.21 (n)
  • 77.73 (a)
Trim14 16
Trim14 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIM14 35
  • 98.64 (n)
  • 97.29 (a)
TRIM14 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim14 35
  • 80.28 (n)
  • 76.39 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIM14 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM14 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM14 35
  • 57.66 (n)
  • 51.44 (a)
TRIM14 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM14 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493056 35
  • 57.41 (n)
  • 50.35 (a)
zebrafish
(Danio rerio)
Actinopterygii TRIM14 (1 of 17) 36
  • 25 (a)
OneToMany
TRIM14 (10 of 17) 36
  • 29 (a)
OneToMany
TRIM14 (11 of 17) 36
  • 33 (a)
OneToMany
TRIM14 (12 of 17) 36
  • 31 (a)
OneToMany
TRIM14 (13 of 17) 36
  • 29 (a)
OneToMany
TRIM14 (14 of 17) 36
  • 28 (a)
OneToMany
TRIM14 (15 of 17) 36
  • 18 (a)
OneToMany
TRIM14 (16 of 17) 36
  • 25 (a)
OneToMany
TRIM14 (17 of 17) 36
  • 31 (a)
OneToMany
TRIM14 (2 of 17) 36
  • 27 (a)
OneToMany
TRIM14 (3 of 17) 36
  • 31 (a)
OneToMany
TRIM14 (4 of 17) 36
  • 25 (a)
OneToMany
TRIM14 (5 of 17) 36
  • 32 (a)
OneToMany
TRIM14 (6 of 17) 36
  • 24 (a)
OneToMany
TRIM14 (7 of 17) 36
  • 24 (a)
OneToMany
TRIM14 (8 of 17) 36
  • 30 (a)
OneToMany
TRIM14 (9 of 17) 36
  • 31 (a)
OneToMany
Species with no ortholog for TRIM14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM14 Gene

ENSEMBL:
Gene Tree for TRIM14 (if available)
TreeFam:
Gene Tree for TRIM14 (if available)

Paralogs for TRIM14 Gene

Paralogs for TRIM14 Gene

(1) SIMAP similar genes for TRIM14 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM14: view

Variants for TRIM14 Gene

Sequence variations from dbSNP and Humsavar for TRIM14 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2296079 - 98,094,912(+) CTCCA(C/T)GGCTT nc-transcript-variant, reference, missense
rs748084 -- 98,105,144(+) CATTG(A/G)TGCCT intron-variant
rs810158 -- 98,118,537(+) ACAGG(C/T)CCTTT intron-variant
rs1059273 -- 98,087,218(-) ACTTA(A/C)ACTAC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1323521 -- 98,105,593(+) ACAAA(A/C)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM14 Gene

Variant ID Type Subtype PubMed ID
nsv6628 CNV Insertion 18451855

Variation tolerance for TRIM14 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM14 Gene

HapMap Linkage Disequilibrium report
TRIM14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM14 Gene

Disorders for TRIM14 Gene

Relevant External Links for TRIM14

Genetic Association Database (GAD)
TRIM14
Human Genome Epidemiology (HuGE) Navigator
TRIM14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM14

No disorders were found for TRIM14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM14 Gene

Publications for TRIM14 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3 4 67
  2. Enhanced expression of trim14 gene suppressed Sindbis virus reproduction and modulated the transcription of a large number of genes of innate immunity. (PMID: 25948474) Nenasheva V.V. … Tarantul V.Z. (Immunol. Res. 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. TRIM14 is a mitochondrial adaptor that facilitates retinoic acid-inducible gene-I-like receptor-mediated innate immune response. (PMID: 24379373) Zhou Z. … Wang J. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for TRIM14 Gene

Sources for TRIM14 Gene

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