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TRIM14 Gene

protein-coding   GIFtS: 53
GCID: GC09M100831

Tripartite Motif Containing 14

(Previous name: tripartite motif-containing 14)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 141 2
Tripartite Motif-Containing 141 2
KIAA01293 5
Tripartite Motif Protein TRIM142
Tripartite Motif-Containing Protein 142

External Ids:    HGNC: 162831   Entrez Gene: 98302   Ensembl: ENSG000001067857   OMIM: 6065565   UniProtKB: Q141423   

Export aliases for TRIM14 gene to outside databases

Previous GC identifers: GC09M091671 GC09M092581 GC09M094304 GC09M096226 GC09M096211 GC09M097926 GC09M099871 GC09M070431


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIM14 Gene:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes
to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Mar 2010)

GeneCards Summary for TRIM14 Gene:
TRIM14 (tripartite motif containing 14) is a protein-coding gene. Diseases associated with TRIM14 include cleft lip, and hepatitis c virus.

UniProtKB/Swiss-Prot: TRI14_HUMAN, Q14142
Function: Inhibits the transcriptional activity of SPI1 in a dose-dependent manner (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM14 gene promoter:
         Tal-1   Pax-5   p300   Nkx2-5   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TRIM14 promoter sequence
   Search Chromatin IP Primers for TRIM14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.33   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9q31.1

TRIM14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM14 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M100831:  view genomic region     (about GC identifiers)

Start:
100,831,557 bp from pter      End:
100,881,494 bp from pter
Size:
49,938 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TRI14_HUMAN, Q14142 (See protein sequence)
Recommended Name: Tripartite motif-containing protein 14  
Size: 442 amino acids; 49773 Da
Subunit: Interacts with SPI1 (By similarity)
Secondary accessions: A8K9W0 E7EQC4 F8W956 Q548W9 Q5TBQ8 Q6ZWL7 Q9BRD8 Q9C020
Alternative splicing: 4 isoforms:  Q14142-1   Q14142-2   Q14142-3   Q14142-4   (Ref.3 (BAC05071) sequence is in conflict in position: 106-108:LKS->PIA)

Explore the universe of human proteins at neXtProt for TRIM14: NX_Q14142

Explore proteomics data for TRIM14 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys77
  • Modification sites at PhosphoSitePlus

  • See TRIM14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_055603.2  NP_150088.1  

    ENSEMBL proteins: 
     ENSP00000364239   ENSP00000344208   ENSP00000343990   ENSP00000428805   ENSP00000445355  

    TRIM14 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for TRIM14
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TRIM14
    GenScript Custom Purified and Recombinant Proteins Services for TRIM14
    Novus Biologicals TRIM14 Protein
    Novus Biologicals TRIM14 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIM14

    TRIM14 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Custom Antibody Services for TRIM14
    Novus Biologicals TRIM14 Antibodies
    Abcam antibodies for TRIM14
    Cloud-Clone Corp. Antibodies for TRIM14
    Search ThermoFisher Antibodies for TRIM14
    LSBio Antibodies in human, mouse, rat for TRIM14

    TRIM14 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for TRIM14
    Cloud-Clone Corp. CLIAs for TRIM14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing

    Selected InterPro protein domains (see all 7):
     IPR006574 PRY
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt
     IPR000315 Znf_B-box
     IPR018355 SPla/RYanodine_receptor_subgr

    Graphical View of Domain Structure for InterPro Entry Q14142

    ProtoNet protein and cluster: Q14142

    3 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: TRI14_HUMAN, Q14142
    Domain: The B-box zinc finger is responsible for inhibition of SPI1-mediated transcriptional activation (By
    similarity)
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain


    TRIM14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI14_HUMAN, Q14142
    Function: Inhibits the transcriptional activity of SPI1 in a dose-dependent manner (By similarity)
    Induction: By interferons alpha and gamma

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    TRIM14 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TRIM14:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM14
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRIM14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM14
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM14

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRIM14:
    hsa-mir-7-5p (MIRT025840), hsa-mir-320a (MIRT044852)

    Block miRNA regulation of human, mouse, rat TRIM14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM14 (see all 15):
    hsa-miR-3910 hsa-miR-520f hsa-miR-539 hsa-miR-24-1* hsa-miR-196a* hsa-miR-1911* hsa-miR-24-2* hsa-miR-145*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TRIM14
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRIM14

    Clone
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    OriGene clones in human, mouse for TRIM14 (see all 20)
    OriGene ORF clones in mouse, rat for TRIM14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TRIM14 (NM_033220)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM14

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TRIM14
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRIM14 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--
    GO:0005737cytoplasm IDA11331580

    TRIM14 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRIM14
    Interactions:

        Search GeneGlobe Interaction Network for TRIM14

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for TRIM14 (Q141423 ENSP000003439904) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629933I2D: score=2 
    SIRT5ENSP000003685524STRING: ENSP00000368552
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ----
    GO:0032897negative regulation of viral transcription IDA18248090
    GO:0045087innate immune response IDA18248090
    GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity IDA--
    GO:0051092positive regulation of NF-kappaB transcription factor activity IDA--

    TRIM14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM14 (TRI14)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRIM14 gene (4 alternative transcripts): 
    NM_014788.3  NM_033219.2  NM_033220.1  NM_033221.1  

    Unigene Cluster for TRIM14:

    Tripartite motif containing 14
    Hs.575631  [show with all ESTs]
    Unigene Representative Sequence: NM_014788
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375098(uc004ayd.2) ENST00000478530 ENST00000341469(uc011luz.1 uc011lva.1 uc004ayh.1)
    ENST00000342043(uc004ayg.1) ENST00000475147 ENST00000478401 ENST00000538344

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRIM14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM14 (see all 15):
    hsa-miR-3910 hsa-miR-520f hsa-miR-539 hsa-miR-24-1* hsa-miR-196a* hsa-miR-1911* hsa-miR-24-2* hsa-miR-145*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRIM14
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM14
    Clone
    Products:
         
    OriGene clones in human, mouse for TRIM14 (see all 20)
    OriGene ORF clones in mouse, rat for TRIM14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TRIM14 (NM_033220)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM14
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRIM14
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM14
      QuantiTect SYBR Green Assays in human, mouse, rat TRIM14
      QuantiFast Probe-based Assays in human, mouse, rat TRIM14

    Additional mRNA sequence: 

    AF220130.1 AF220131.1 AK055833.1 AK097480.1 AK292825.1 AK303366.1 AK316464.1 BC006333.2 
    D50919.1 

    15 DOTS entries:

    DT.99935837  DT.314392  DT.87010450  DT.101980152  DT.100818587  DT.100657015  DT.40241205  DT.91756010 
    DT.95080406  DT.75122784  DT.91756012  DT.95360447  DT.121164977  DT.314393  DT.95333821 

    Selected AceView cDNA sequences (see all 201):

    CB132586 AW294796 BX105492 CA447083 NM_014788 AK123739 CA398025 CA421792 
    AA382686 BM797268 NM_033219 CA941142 BX436852 CA777422 CR598301 AA371092 
    BM126342 BU167752 BE047409 AA078807 CK818945 CF140758 AL522688 AA447243 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRIM14 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10
    SP1:                    -     -     -     -                                                     -                                   -         
    SP2:                    -     -     -     -                                                     -                                             
    SP3:                                                                                            -                                             
    SP4:                    -     -     -     -     -     -     -                                   -                                             
    SP5:                    -     -                                                                                                               


    ECgene alternative splicing isoforms for TRIM14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGTAAGGG
    TRIM14 Expression
    About this image

    TRIM14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.575631

    UniProtKB/Swiss-Prot: TRI14_HUMAN, Q14142
    Tissue specificity: Highest expression in liver; undetectable in skeletal muscle

        Custom PCR Arrays for TRIM14
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    QuantiFast Probe-based Assays in human, mouse, rat TRIM14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM14 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim141 , 5 tripartite motif-containing 141, 5 81.21(n)1
    77.73(a)1
      4 (24.84 cM)5
    747351  NM_029077.31  NP_083353.11 
     464937815 
    chicken
    (Gallus gallus)
    Aves TRIM141 tripartite motif containing 14 57.66(n)
    51.44(a)
      427282  NM_001031431.1  NP_001026602.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRIM146
    tripartite motif containing 14
    43(a)
    1 ↔ 1
    GL343201.1(2398183-2418508)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004930561 tripartite motif-containing protein 14-like 57.41(n)
    50.35(a)
      100493056  XM_002935873.2  XP_002935919.2 
    zebrafish
    (Danio rerio)
    Actinopterygii TRIM14 (11 of 17)6
    TRIM14 (5 of 17)6
    (see all 17)
    tripartite motif containing 14
    (see all 17)
    33(a)
    32(a)
    (see all 17)
    many → 1
    many → 1
    (see all 17)
    4(35789442-35791396) ENSDARG00000090919
    Zv9_scaffold3519(179834-180724) ENSDARG00000086581


    ENSEMBL Gene Tree for TRIM14 (if available)
    TreeFam Gene Tree for TRIM14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM14 gene
    1 SIMAP similar gene for TRIM14 using alignment to 3 protein entries:     TRI14_HUMAN (see all proteins):
    MEFV

    TRIM14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM14 (see all 783)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs756471621,2
    F--100845987(+) ACTTCC/TATTCA 1 -- int11Minor allele frequency- T:0.01EA 120
    rs1815005981,2
    --100846203(+) GTAAGC/TGAGAA 3 -- ds5001 int10--------
    rs1445710261,2
    --100846262(+) AGTTAA/GTCAGG 3 -- ds5001 int10--------
    rs1867365141,2
    --100846410(+) GAAGCA/GGAAGA 3 -- ds5001 int10--------
    rs1906466311,2
    --100846414(+) CGGAAA/GATTCA 3 -- ds5001 int10--------
    rs1120639141,2
    F--100846428(+) GACCTC/TAAGAG 3 -- ds5001 int11Minor allele frequency- T:0.50CSA 2
    rs1829083851,2
    --100846470(+) CATTCA/GCAAAT 3 -- ds5001 int10--------
    rs24177271,2
    C,F,A,H--100846475(+) ACAAAT/CGTTTA 3 -- ds5001 int16Minor allele frequency- C:0.34NA WA EA 364
    rs1861550301,2
    --100846544(+) GCGGAC/TGATGT 3 -- ds5001 int10--------
    rs1424881141,2
    C--100846572(+) CTTACA/CTGTGG 3 -- ds5001 int10--------

    HapMap Linkage Disequilibrium report for TRIM14 (100831557 - 100881494 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TRIM14:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6628CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM14
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606556    OMIM disorders: --

    4 diseases for TRIM14:    About MalaCards
    cleft lip    hepatitis c virus    hepatitis c    hepatitis


    TRIM14 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRIM14
    Human Genome Epidemiology (HuGE) Navigator: TRIM14 (1 document)

    Export disorders for TRIM14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM14 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with TRIM14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2, 3 Reymond A.... Ballabio A. (EMBO J. 2001)
    2. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    6. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2 Nagase T.... Nomura N. (DNA Res. 1995)
    7. TRIM14 is a mitochondrial adaptor that facilitates retinoic acid-inducible gene-I-like receptor-mediated innate immune response. (PubMed id 24379373)1 Zhou Z....Wang J. (Proc. Natl. Acad. Sci. U.S.A. 2014)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication. (PubMed id 22711689)2 Metz P....Bartenschlager R. (Hepatology 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9830 HGNC: 16283 AceView: TRIM14 Ensembl:ENSG00000106785 euGenes: HUgn9830
    ECgene: TRIM14 H-InvDB: TRIM14

    (According to HUGE)
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    HUGE: KIAA0129

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRIM14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM14 gene:
    Search GeneIP for patents involving TRIM14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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