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Aliases for TRIM14 Gene

Aliases for TRIM14 Gene

  • Tripartite Motif Containing 14 2 3
  • KIAA0129 4 6
  • Tripartite Motif-Containing 14 2

External Ids for TRIM14 Gene

Previous GeneCards Identifiers for TRIM14 Gene

  • GC09M091671
  • GC09M092581
  • GC09M094304
  • GC09M096226
  • GC09M096211
  • GC09M097926
  • GC09M099871
  • GC09M100831
  • GC09M070431

Summaries for TRIM14 Gene

Entrez Gene Summary for TRIM14 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for TRIM14 Gene

TRIM14 (Tripartite Motif Containing 14) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TRIM14 Gene

  • Inhibits the transcriptional activity of SPI1 in a dose-dependent manner.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM14 Gene

Genomics for TRIM14 Gene

Regulatory Elements for TRIM14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIM14 Gene

Start:
98,035,794 bp from pter
End:
98,119,413 bp from pter
Size:
83,620 bases
Orientation:
Minus strand

Genomic View for TRIM14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM14 Gene

Proteins for TRIM14 Gene

  • Protein details for TRIM14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14142-TRI14_HUMAN
    Recommended name:
    Tripartite motif-containing protein 14
    Protein Accession:
    Q14142
    Secondary Accessions:
    • A8K9W0
    • E7EQC4
    • F8W956
    • Q548W9
    • Q5TBQ8
    • Q6ZWL7
    • Q9BRD8
    • Q9C020

    Protein attributes for TRIM14 Gene

    Size:
    442 amino acids
    Molecular mass:
    49773 Da
    Quaternary structure:
    • Interacts with SPI1.

    Alternative splice isoforms for TRIM14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM14 Gene

Proteomics data for TRIM14 Gene at MOPED

Post-translational modifications for TRIM14 Gene

  • Ubiquitination at Lys77
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM14 Gene

No data available for DME Specific Peptides for TRIM14 Gene

Domains for TRIM14 Gene

Gene Families for TRIM14 Gene

HGNC:
  • TRIM :Tripartite motif containing / Tripartite motif containing

Suggested Antigen Peptide Sequences for TRIM14 Gene

Graphical View of Domain Structure for InterPro Entry

Q14142

UniProtKB/Swiss-Prot:

TRI14_HUMAN :
  • Q14142
Domain:
  • The B-box zinc finger is responsible for inhibition of SPI1-mediated transcriptional activation.
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
genes like me logo Genes that share domains with TRIM14: view

Function for TRIM14 Gene

Molecular function for TRIM14 Gene

UniProtKB/Swiss-Prot Function: Inhibits the transcriptional activity of SPI1 in a dose-dependent manner.
UniProtKB/Swiss-Prot Induction: By interferons alpha and gamma.

Gene Ontology (GO) - Molecular Function for TRIM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM14: view
genes like me logo Genes that share phenotypes with TRIM14: view

Animal Model Products

CRISPR Products

miRNA for TRIM14 Gene

miRTarBase miRNAs that target TRIM14

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIM14 Gene

Localization for TRIM14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM14 Gene COMPARTMENTS Subcellular localization image for TRIM14 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TRIM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IDA 11331580
genes like me logo Genes that share ontologies with TRIM14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM14 Gene

Pathways for TRIM14 Gene

SuperPathways for TRIM14 Gene

No Data Available

Interacting Proteins for TRIM14 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000343990%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000356480%0d%0a9606.ENSP00000368552%0d%0a
Selected Interacting proteins: ENSP00000343990 Q14142-TRI14_HUMAN for TRIM14 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TRIM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032897 negative regulation of viral transcription IDA 18248090
GO:0045087 innate immune response IDA 18248090
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IDA 23077300
GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA 23077300
genes like me logo Genes that share ontologies with TRIM14: view

No data available for Pathways by source for TRIM14 Gene

Transcripts for TRIM14 Gene

Unigene Clusters for TRIM14 Gene

Tripartite motif containing 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM14

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM14 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10
SP1: - - - - - -
SP2: - - - - -
SP3: -
SP4: - - - - - - - -
SP5: - -
SP6: - - -
SP7: - -
SP8:

Relevant External Links for TRIM14 Gene

GeneLoc Exon Structure for
TRIM14
ECgene alternative splicing isoforms for
TRIM14

Expression for TRIM14 Gene

mRNA expression in normal human tissues for TRIM14 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRIM14 Gene

SOURCE GeneReport for Unigene cluster for TRIM14 Gene Hs.575631

mRNA Expression by UniProt/SwissProt for TRIM14 Gene

Q14142-TRI14_HUMAN
Tissue specificity: Highest expression in liver; undetectable in skeletal muscle
genes like me logo Genes that share expressions with TRIM14: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRIM14 Gene

Orthologs for TRIM14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM14 35
  • 98.64 (n)
  • 97.29 (a)
TRIM14 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM14 35
  • 84.49 (n)
  • 80.58 (a)
TRIM14 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM14 35
  • 86.88 (n)
  • 81.45 (a)
TRIM14 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim14 35
  • 81.21 (n)
  • 77.73 (a)
Trim14 16
Trim14 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM14 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM14 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim14 35
  • 80.28 (n)
  • 76.39 (a)
chicken
(Gallus gallus)
Aves TRIM14 35
  • 57.66 (n)
  • 51.44 (a)
TRIM14 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM14 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493056 35
  • 57.41 (n)
  • 50.35 (a)
zebrafish
(Danio rerio)
Actinopterygii TRIM14 (1 of 17) 36
  • 25 (a)
OneToMany
TRIM14 (10 of 17) 36
  • 29 (a)
OneToMany
TRIM14 (11 of 17) 36
  • 33 (a)
OneToMany
TRIM14 (12 of 17) 36
  • 31 (a)
OneToMany
TRIM14 (13 of 17) 36
  • 29 (a)
OneToMany
TRIM14 (14 of 17) 36
  • 28 (a)
OneToMany
TRIM14 (15 of 17) 36
  • 18 (a)
OneToMany
TRIM14 (16 of 17) 36
  • 25 (a)
OneToMany
TRIM14 (17 of 17) 36
  • 31 (a)
OneToMany
TRIM14 (2 of 17) 36
  • 27 (a)
OneToMany
TRIM14 (3 of 17) 36
  • 31 (a)
OneToMany
TRIM14 (4 of 17) 36
  • 25 (a)
OneToMany
TRIM14 (5 of 17) 36
  • 32 (a)
OneToMany
TRIM14 (6 of 17) 36
  • 24 (a)
OneToMany
TRIM14 (7 of 17) 36
  • 24 (a)
OneToMany
TRIM14 (8 of 17) 36
  • 30 (a)
OneToMany
TRIM14 (9 of 17) 36
  • 31 (a)
OneToMany
Species with no ortholog for TRIM14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM14 Gene

ENSEMBL:
Gene Tree for TRIM14 (if available)
TreeFam:
Gene Tree for TRIM14 (if available)

Paralogs for TRIM14 Gene

Selected SIMAP similar genes for TRIM14 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM14: view

No data available for Paralogs for TRIM14 Gene

Variants for TRIM14 Gene

Sequence variations from dbSNP and Humsavar for TRIM14 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs748084 -- 98,105,144(+) CATTG(A/G)TGCCT intron-variant
rs810158 -- 98,118,537(+) ACAGG(C/T)CCTTT intron-variant
rs1059273 -- 98,087,218(-) ACTTA(A/C)ACTAC utr-variant-3-prime, intron-variant
rs1323521 -- 98,105,593(+) ACAAA(A/C)AAACA intron-variant
rs1323522 -- 98,105,865(+) AAAAA(A/C)TCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM14 Gene

Variant ID Type Subtype PubMed ID
nsv6628 CNV Insertion 18451855

Relevant External Links for TRIM14 Gene

HapMap Linkage Disequilibrium report
TRIM14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM14 Gene

Disorders for TRIM14 Gene

Relevant External Links for TRIM14

Genetic Association Database (GAD)
TRIM14
Human Genome Epidemiology (HuGE) Navigator
TRIM14
genes like me logo Genes that share disorders with TRIM14: view

No data available for UniProtKB/Swiss-Prot for TRIM14 Gene

Publications for TRIM14 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TRIM14 Gene

Sources for TRIM14 Gene

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