Aliases for TRIM13 Gene
External Ids for TRIM13 Gene
Previous HGNC Symbols for TRIM13 Gene
Previous GeneCards Identifiers for TRIM13 Gene
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRIM13 Gene
TRIM13 (Tripartite Motif Containing 13) is a Protein Coding gene. Diseases associated with TRIM13 include Chronic Lymphocytic Leukemia and Pain Agnosia. Among its related pathways are Transport to the Golgi and subsequent modification and Calnexin/calreticulin cycle. GO annotations related to this gene include ligase activity and signal transducer activity. An important paralog of this gene is TRIM59.
UniProtKB/Swiss-Prot for TRIM13 Gene
E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.