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Aliases for TRIM13 Gene

Aliases for TRIM13 Gene

  • Tripartite Motif Containing 13 2 3
  • Ret Finger Protein 2 2 3 4
  • RFP2 3 4 6
  • LEU5 3 4 6
  • B-Cell Chronic Lymphocytic Leukemia Tumor Suppressor Leu5 3 4
  • Tripartite Motif-Containing Protein 13 3 4
  • Tripartite Motif-Containing 13 2 3
  • Putative Tumor Suppressor RFP2 3 4
  • Leukemia-Associated Protein 5 3 4
  • RING Finger Protein 77 3 4
  • RNF77 3 4
  • E3 Ubiquitin-Protein Ligase TRIM13 3
  • Tripartite Motif Protein 13 3
  • CLL-Associated RING Finger 3
  • EC 6.3.2.- 4
  • DLEU5 3
  • CAR 3

External Ids for TRIM13 Gene

Previous HGNC Symbols for TRIM13 Gene

  • RFP2

Previous GeneCards Identifiers for TRIM13 Gene

  • GC13P049472
  • GC13P050570
  • GC13P031366

Summaries for TRIM13 Gene

Entrez Gene Summary for TRIM13 Gene

  • This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM13 Gene

TRIM13 (Tripartite Motif Containing 13) is a Protein Coding gene. Diseases associated with TRIM13 include chronic lymphocytic leukemia and leukemia. GO annotations related to this gene include ubiquitin-protein transferase activity and signal transducer activity. An important paralog of this gene is MID1.

UniProtKB/Swiss-Prot for TRIM13 Gene

  • E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM13 Gene

Genomics for TRIM13 Gene

Regulatory Elements for TRIM13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIM13 Gene

Start:
49,995,888 bp from pter
End:
50,020,481 bp from pter
Size:
24,594 bases
Orientation:
Plus strand

Genomic View for TRIM13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM13 Gene

Proteins for TRIM13 Gene

  • Protein details for TRIM13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60858-TRI13_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM13
    Protein Accession:
    O60858
    Secondary Accessions:
    • B2RB49
    • Q5UBW0
    • Q5W0U8
    • Q5W0U9
    • Q9BQ47
    • Q9C021

    Protein attributes for TRIM13 Gene

    Size:
    407 amino acids
    Molecular mass:
    46988 Da
    Quaternary structure:
    • Interacts (via C-terminal domain) with VCP. Interacts with AKT1; the interaction ubiquitinates AKT1 and leads to its proteasomal degradation. Interacts with MDM2; the interaction ubiquitinates AKT1 and leads to its proteasomal degradation. Interacts with p62/SQSTM1.
    Miscellaneous:
    • Located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia

    Alternative splice isoforms for TRIM13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM13 Gene

Proteomics data for TRIM13 Gene at MOPED

Post-translational modifications for TRIM13 Gene

  • Auto-ubiquitinated; requires the RING-type zinc finger. Auto-polyubiquitination leads to proteasomal degradation.
  • Ubiquitination at Lys125
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TRIM13 Gene

Domains for TRIM13 Gene

Gene Families for TRIM13 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Protein Domains for TRIM13 Gene

Suggested Antigen Peptide Sequences for TRIM13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60858

UniProtKB/Swiss-Prot:

TRI13_HUMAN :
  • O60858
Domain:
  • The coiled-coil domain is required for the induction of autophagy during endoplasmic reticulum (ER) stress
  • The RING-type zinc finger is required for auto-polyubiquitination
  • The C-terminal domain transmembrane domain is indispensable for the localization to the ER
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM13: view

Function for TRIM13 Gene

Molecular function for TRIM13 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.

Enzyme Numbers (IUBMB) for TRIM13 Gene

Gene Ontology (GO) - Molecular Function for TRIM13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 17314412
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 17314412
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRIM13: view

Phenotypes for TRIM13 Gene

GenomeRNAi human phenotypes for TRIM13:
genes like me logo Genes that share phenotypes with TRIM13: view

Animal Model Products

CRISPR Products

miRNA for TRIM13 Gene

miRTarBase miRNAs that target TRIM13

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIM13 Gene

Localization for TRIM13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM13 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Concentrates and colocalizes with p62/SQSTM1 and ZFYVE1 at the perinuclear endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM13 Gene COMPARTMENTS Subcellular localization image for TRIM13 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 3
cytosol 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TRIM13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA 11331580
GO:0005789 endoplasmic reticulum membrane IDA 17314412
GO:0016021 integral component of membrane IEA --
GO:0097038 perinuclear endoplasmic reticulum IDA 17314412
genes like me logo Genes that share ontologies with TRIM13: view

Pathways for TRIM13 Gene

SuperPathways for TRIM13 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot O60858-TRI13_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Interacting Proteins for TRIM13 Gene

Gene Ontology (GO) - Biological Process for TRIM13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IMP 12761501
GO:0009653 anatomical structure morphogenesis TAS 9599022
GO:0010332 response to gamma radiation IEP 21333377
GO:0010942 positive regulation of cell death IDA 21333377
GO:0016239 positive regulation of macroautophagy IDA 22178386
genes like me logo Genes that share ontologies with TRIM13: view

No data available for Pathways by source for TRIM13 Gene

Compounds for TRIM13 Gene

(3) Drugbank Compounds for TRIM13 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Dihydromorphine
509-60-4 target agonist
Diprenorphine
14357-78-9 target
Etorphine
  • 19-Propylorvinol
14521-96-1 target agonist

(1) Novoseek inferred chemical compound relationships for TRIM13 Gene

Compound -log(P) Hits PubMed IDs
calcium 18 4
genes like me logo Genes that share compounds with TRIM13: view

Transcripts for TRIM13 Gene

Unigene Clusters for TRIM13 Gene

Tripartite motif containing 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM13

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM13 Gene

No ASD Table

Relevant External Links for TRIM13 Gene

GeneLoc Exon Structure for
TRIM13
ECgene alternative splicing isoforms for
TRIM13

Expression for TRIM13 Gene

mRNA expression in normal human tissues for TRIM13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRIM13 Gene

SOURCE GeneReport for Unigene cluster for TRIM13 Gene Hs.436922

genes like me logo Genes that share expressions with TRIM13: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIM13 Gene

Orthologs for TRIM13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM13 35
  • 99.51 (n)
  • 99.26 (a)
TRIM13 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM13 35
  • 90.25 (n)
  • 92.38 (a)
TRIM13 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM13 35
  • 91.73 (n)
  • 92.14 (a)
TRIM13 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim13 35
  • 86.49 (n)
  • 88.94 (a)
Trim13 16
Trim13 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM13 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM13 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim13 35
  • 85.5 (n)
  • 87.47 (a)
chicken
(Gallus gallus)
Aves TRIM13 35
  • 72.86 (n)
  • 75.06 (a)
TRIM13 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM13 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492997 35
  • 62.99 (n)
  • 60.05 (a)
zebrafish
(Danio rerio)
Actinopterygii trim13 35
  • 55.73 (n)
  • 50.89 (a)
trim13 36
  • 48 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToMany
Species with no ortholog for TRIM13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM13 Gene

ENSEMBL:
Gene Tree for TRIM13 (if available)
TreeFam:
Gene Tree for TRIM13 (if available)

Paralogs for TRIM13 Gene

Selected SIMAP similar genes for TRIM13 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TRIM13 Gene

genes like me logo Genes that share paralogs with TRIM13: view

Variants for TRIM13 Gene

Sequence variations from dbSNP and Humsavar for TRIM13 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_013512 -

Structural Variations from Database of Genomic Variants (DGV) for TRIM13 Gene

Variant ID Type Subtype PubMed ID
esv2747402 CNV Deletion 23290073
esv2661834 CNV Deletion 23128226

Relevant External Links for TRIM13 Gene

HapMap Linkage Disequilibrium report
TRIM13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM13 Gene

Disorders for TRIM13 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for TRIM13 Gene including...

Search for TRIM13 Gene in MalaCards »

(4) Novoseek inferred disease relationships for TRIM13 Gene

Disease -log(P) Hits PubMed IDs
lymphocytic leukemia chronic b-cell 62.5 1
hypercalcemia 55.7 3
hyperparathyroidism 51.6 2
tumors 0 2
genes like me logo Genes that share disorders with TRIM13: view

No data available for UniProtKB/Swiss-Prot for TRIM13 Gene

Publications for TRIM13 Gene

  1. A cosmid and cDNA fine physical map of a human chromosome 13q14 region frequently lost in B-cell chronic lymphocytic leukemia and identification of a new putative tumor suppressor gene, Leu5. (PMID: 9599022) Kapanadze B. … Yankovsky N. (FEBS Lett. 1998) 2 3 4 23
  2. The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD. (PMID: 17314412) Lerner M. … Sangfelt O. (Mol. Biol. Cell 2007) 3 4 23
  3. Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia. (PMID: 11264177) Migliazza A. … Dalla-Favera R. (Blood 2001) 3 4 23
  4. RFP2, c13ORF1, and FAM10A4 are the most likely tumor suppressor gene candidates for B-cell chronic lymphocytic leukemia. (PMID: 14499696) van Everdink W.J. … Buys C.H. (Cancer Genet. Cytogenet. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for TRIM13 Gene

Sources for TRIM13 Gene

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