Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM13 Gene

protein-coding   GIFtS: 46
GCID: GC13P050570

tripartite motif containing 13

(Previous names: ret finger protein 2, tripartite motif-containing 13 )
(Previous symbol: RFP2)
 Explore 8 diseases affiliated with
TRIM13 via our new
 Human Malady Compendium 
Biological research products
for TRIM13
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Tripartite Motif Containing 131 2     Tripartite Motif-Containing Protein 132 3
RFP21 2 3 5     B-Cell Chronic Lymphocytic Leukemia Tumor Suppressor Leu52 3
Ret Finger Protein 21 2 3     RING Finger Protein 772 3
RNF771 2 3     Leu51
LEU52 3 5     CAR2
DLEU51 2     CLL-Associated RING Finger2
Tripartite Motif-Containing 131 2     E3 Ubiquitin-Protein Ligase TRIM132
Leukemia-Associated Protein 52 3     Tripartite Motif Protein 132
Putative Tumor Suppressor RFP22 3     EC 6.3.2.-3

External Ids:    HGNC: 99761   Entrez Gene: 102062   Ensembl: ENSG000002049777   OMIM: 6056615   UniProtKB: O608583   

Export aliases for TRIM13 gene to outside databases

Previous GC identifers: GC13P049472 GC13P031366


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRIM13:
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a
RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the
minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants
have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TRI13_HUMAN, O60858
Function: E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from
the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as
well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53
stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1
proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM13 gene promoter:
         HSF1 (long)   MEF-2A   PPAR-gamma1   POU2F1   POU2F1a   HOXA5   Cart-1   HSF1short   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TRIM13 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14

TRIM13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM13 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P050570:  view genomic region     (about GC identifiers)

Start:
50,570,024 bp from pter      End:
50,594,617 bp from pter
Size:
24,594 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRI13_HUMAN, O60858 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM13  
Size: 407 amino acids; 46988 Da
Subunit: Interacts (via C-terminal domain) with VCP. Interacts with AKT1; the interaction ubiquitinates AKT1 and leads
to its proteasomal degradation. Interacts with MDM2; the interaction ubiquitinates AKT1 and leads to its proteasomal
degradation. Interacts with p62/SQSTM1
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Concentrates and colocalizes
with p62/SQSTM1 and ZFYVE1 at the perinuclear endoplasmic reticulum
Miscellaneous: Located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia
Secondary accessions: B2RB49 Q5UBW0 Q5W0U8 Q5W0U9 Q9BQ47 Q9C021
Alternative splicing: 3 isoforms:  O60858-1   O60858-2   O60858-3   

Explore the universe of human proteins at neXtProt for TRIM13: NX_O60858

Post-translational modifications:

  • Auto-ubiquitinated; requires the RING-type zinc finger. Auto-polyubiquitination leads to proteasomal degradation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60858

  • TRIM13 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001007279.1  NP_005789.2  NP_434698.1  NP_998755.1  

    ENSEMBL proteins: 
     ENSP00000404586   ENSP00000367425   ENSP00000412943   ENSP00000367424   ENSP00000348299  
     ENSP00000399206   ENSP00000298772  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: TRIM13
    OriGene Protein Over-expression Lysate (see all 4): TRIM13
    OriGene Custom Protein Services for TRIM13 
    GenScript Custom Purified and Recombinant Proteins Services for TRIM13
    Novus Biologicals TRIM13 Proteins
    Novus Biologicals TRIM13 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TRIM13

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11331580
    GO:0005789endoplasmic reticulum membrane IDA17314412
    GO:0016021integral to membrane IEA--
    GO:0097038perinuclear endoplasmic reticulum IDA--


    TRIM13 for ontologies           About GeneDecksing



    TRIM13 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: TRIM13
    OriGene Custom Antibody Services for TRIM13 
    GenScript Custom Superior Antibodies Services for TRIM13
    Novus Biologicals TRIM13 Antibodies
    Search for Antibodies for TRIM13 at Abcam  
    Uscn Antibodies for TRIM13
    ThermoFisher Antibodies for TRIM13

    Assay Products for TRIM13: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRIM13
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TRIM13


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TRIM13 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR000315 Znf_B-box
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry O60858

    ProtoNet protein and cluster: O60858

    2 Blocks protein families:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: TRI13_HUMAN, O60858
    Domain: The coiled-coil domain is required for the induction of autophagy during endoplasmic reticulum (ER) stress
    Domain: The RING-type zinc finger is required for auto-polyubiquitination
    Domain: The C-terminal domain transmembrane domain is indispensable for the localization to the ER
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TRI13_HUMAN, O60858
    Function: E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from
    the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as
    well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53
    stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1
    proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 4): TRIM13
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM13
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM13 (see all 24):
    hsa-miR-495 hsa-miR-16-2* hsa-miR-513a-5p hsa-miR-3660 hsa-miR-888* hsa-miR-515-5p hsa-miR-499-5p hsa-miR-208b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM13 (see all 7)
    OriGene shRNA RFP: TRIM13
    OriGene siRNA: TRIM13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM13

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRIM13

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM13 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM13 (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): TRIM13 (NM_213590)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM13 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRIM13
    Search LifeMap BioReagents cell lines for TRIM13

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM13

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA17314412
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--


    TRIM13 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for TRIM13:
     Decreased viability  Increased cell death HMECs cel 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: TRI13_HUMAN, O60858
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for TRIM13 (O608583 ENSP000002987724) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1CQ139363, ENSP000002663764I2D: score=2 STRING: ENSP00000266376
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    AKT1P317493, ENSP000002702024I2D: score=1 STRING: ENSP00000270202
    ROBO2Q9HCK43, ENSP000004171644I2D: score=1 STRING: ENSP00000417164
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IMP12761501
    GO:0009653anatomical structure morphogenesis TAS9599022
    GO:0010332response to gamma radiation IEP--
    GO:0010942positive regulation of cell death IDA--
    GO:0016239positive regulation of macroautophagy IDA--


    TRIM13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRIM13 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM13

    3 DrugBank Compounds for TRIM13    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Dihydromorphine-- 509-60-4targetagonist2985086 2835832 2855368 2828423 1654566
    Diprenorphine-- 14357-78-9target--6287305 6270660 2982865 8626742 6124875
    Etorphine19-Propylorvinol (see all 7)14521-96-1targetagonist3037028 3036471 6247160 2828423 6124875

    1 Novoseek chemical compound relationship for TRIM13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 18 8 12409307 (2), 10843194 (1), 10679256 (1)

    Search CenterWatch for drugs/clinical trials and news about TRIM13 / TRI13 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRIM13 gene (4 alternative transcripts): 
    NM_001007278.1  NM_005798.3  NM_052811.2  NM_213590.1  

    Unigene Cluster for TRIM13:

    Tripartite motif containing 13
    Hs.436922  [show with all ESTs]
    Unigene Representative Sequence: NM_213590
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000442421 ENST00000378183 ENST00000474805 ENST00000420995 ENST00000478111
    ENST00000378182(uc001vdp.1 uc001vdq.1 uc001vdr.1 uc001vds.1)
    ENST00000356017 ENST00000457662 ENST00000298772

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 4): TRIM13
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM13
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM13 (see all 24):
    hsa-miR-495 hsa-miR-16-2* hsa-miR-513a-5p hsa-miR-3660 hsa-miR-888* hsa-miR-515-5p hsa-miR-499-5p hsa-miR-208b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM13 (see all 7)
    OriGene shRNA RFP: TRIM13
    OriGene siRNA: TRIM13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM13
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM13 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM13 (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): TRIM13 (NM_213590)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM13 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM13
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIM13
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM13

    Additional cDNA sequence: 

    AF220127.1 AF241850.1 AJ224819.1 AK001806.1 AK314496.1 AL360196.1 AY191002.1 AY455758.1 
    AY764035.1 BC003579.1 BC063407.1 

    24 DOTS entries:

    DT.213704  DT.100778752  DT.120774819  DT.109500  DT.120774799  DT.95099718  DT.40194635  DT.97834833 
    DT.120774888  DT.92427411  DT.95341736  DT.97823488  DT.302847  DT.100713180  DT.121638456  DT.95208533 
    DT.120774735  DT.100734259  DT.120774813  DT.120775008  DT.95279577  DT.120774940  DT.120775007  DT.449720 

    24/229 AceView cDNA sequences (see all 229):

    BU630484 AI800706 AY169388 BE542685 BQ448073 AA815248 H87332 BX117505 
    AI572397 AI832658 NM_173605 CB138184 BQ003738 AI523269 BM711217 BX116021 
    AI359312 NM_005798 BC063407 BF939833 AA992127 BM985019 NM_052811 AA446884 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TRIM13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM13

    SOURCE GeneReport for Unigene cluster: Hs.436922
        SABiosciences Expression via Pathway-Focused PCR Array including TRIM13: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM13
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIM13
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM13
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM13 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TRIM131 tripartite motif containing 13 72.86(n)
    75.06(a)
      418872  XM_417067.3  XP_417067.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRIM136
    --
    70(a)
    1 ↔ 1
    1(137605129-137606355)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ075015.12   -- 71.73(n)    BJ075015.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trim131 tripartite motif-containing 13 55.64(n)
    50.89(a)
      553630  NM_001020603.1  NP_001018439.1 


    ENSEMBL Gene Tree for TRIM13 (if available)
    TreeFam Gene Tree for TRIM13 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM13 gene
    FSD1L2  TRIM462  TRIM632  TRIM592  TRIM672  TRIM92  TRIM362  MID12  
    TRIM552  MID22  TRIM542  FSD12  
    2 SIMAP similar genes for TRIM13 using alignment to 2 protein entries:     TRI13_HUMAN (see all proteins):
    DKFZp686N1030    TRIM59

    TRIM13 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TRIM13
    PGOHUM00000249167


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM13
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TRIM13 for disorders           About GeneDecksing

    OMIM gene information: 605661    OMIM disorders: --

    8 diseases for TRIM13:    About MalaCards
    chronic lymphocytic leukemia    lymphocytic leukemia    leukemia    mantle cell lymphoma
    hypercalcemia    hypercalciuria    hyperparathyroidism    pertussis

    4 Novoseek disease relationships for TRIM13 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphocytic leukemia chronic b-cell 62.5 1 9599022 (1)
    hypercalcemia 55.7 4 15292296 (2), 16441824 (1)
    hyperparathyroidism 51.6 3 15292296 (2)
    tumors 0 4 18070444 (1), 9599022 (1)


    Export disorders for TRIM13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM13 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with TRIM13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cosmid and cDNA fine physical map of a human chromosome 13q14 region frequently lost in B-cell chronic lymphocytic leukemia and identification of a new putative tumor suppressor gene, Leu5. (PubMed id 9599022)1, 2, 3, 9 Kapanadze B....Yankovsky N. (1998)
    2. The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD. (PubMed id 17314412)1, 2, 9 Lerner M....Sangfelt O. (2007)
    3. Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia. (PubMed id 11264177)1, 2, 9 Migliazza A.... Dalla-Favera R. (2001)
    4. TRIM13 regulates ER stress induced autophagy and clon ogenic ability of the cells. (PubMed id 22178386)1, 2 Tomar D....Singh R. (2012)
    5. Ret finger protein 2 enhances ionizing radiation-indu ced apoptosis via degradation of AKT and MDM2. (PubMed id 21333377)1, 2 Joo H.M....Jin Y.W. (2011)
    6. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. RFP2, c13ORF1, and FAM10A4 are the most likely tumor suppressor gene candidates for B-cell chronic lymphocytic leukemia. (PubMed id 14499696)1, 2 van Everdink W.J.... Buys C.H. (2003)
    10. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2 Reymond A.... Ballabio A. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10206 HGNC: 9976 AceView: RFP2 Ensembl:ENSG00000204977 euGenes: HUgn10206
    ECgene: TRIM13 H-InvDB: TRIM13

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRIM13 gene:
    Search GeneIP for patents involving TRIM13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for TRIM13   OriGene shRNA RFP for TRIM13  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM13   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM13  
     OriGene Protein Over-expression Lysate for TRIM13   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TRIM13   OriGene 3'-UTR Clone for TRIM13  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM13   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM13  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for TRIM13   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRIM13   OriGene Custom Protein Services for TRIM13  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIM13
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM13
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM13
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM13
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM13
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM13
     GenScript Custom Purified and Recombinant Proteins Services for TRIM13 GenScript cDNA clones with any tag delivered in your preferred vector for TRIM13
     GenScript Custom Assay Services for TRIM13 GenScript Custom Superior Antibodies Services for TRIM13
     GenScript Custom overexpressing Cell Line Services for TRIM13 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TRIM13 promoter
     Search Chromatin IP Primers for TRIM13
     RT2 qPCR Primer Assay in human, mouse, rat TRIM13
     Search GNC Networks for TRIM13
     SABiosciences PCR Arrays including human, mouse, rat TRIM13
     Search Tocris compounds for TRIM13
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TRIM13 antibodies
     TRIM13 proteins
     TRIM13 lysates
     Search for Antibodies for TRIM13 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TRIM13
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TRIM13 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TRIM13
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM13
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TRIM13
     SwitchGear Promoter luciferase reporter plasmids for TRIM13
     ThermoFisher Antibodies for TRIM13
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM13
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TRIM13 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4