Aliases for TRIM13 Gene
External Ids for TRIM13 Gene
Previous HGNC Symbols for TRIM13 Gene
Previous GeneCards Identifiers for TRIM13 Gene
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRIM13 Gene
TRIM13 (Tripartite Motif Containing 13) is a Protein Coding gene. Diseases associated with TRIM13 include Chronic Lymphocytic Leukemia and Pain Agnosia. GO annotations related to this gene include ligase activity and signal transducer activity. An important paralog of this gene is TRIM59.
UniProtKB/Swiss-Prot for TRIM13 Gene
E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.