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Aliases for TRIM11 Gene

Aliases for TRIM11 Gene

  • Tripartite Motif Containing 11 2 3 5
  • Tripartite Motif-Containing Protein 11 3 4
  • Tripartite Motif-Containing 11 2 3
  • RING Finger Protein 92 3 4
  • RNF92 3 4
  • Protein BIA1 4
  • EC 6.3.2.- 4
  • BIA1 3

External Ids for TRIM11 Gene

Previous GeneCards Identifiers for TRIM11 Gene

  • GC01M227052
  • GC01M224319
  • GC01M224966
  • GC01M225556
  • GC01M225313
  • GC01M224888
  • GC01M226647
  • GC01M228581
  • GC01M199095

Summaries for TRIM11 Gene

Entrez Gene Summary for TRIM11 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM11 Gene

TRIM11 (Tripartite Motif Containing 11) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is TRIM58.

UniProtKB/Swiss-Prot for TRIM11 Gene

  • E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.

Gene Wiki entry for TRIM11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM11 Gene

Genomics for TRIM11 Gene

Regulatory Elements for TRIM11 Gene

Promoters for TRIM11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM11 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM11 Gene

Chromosome:
1
Start:
228,393,672 bp from pter
End:
228,406,877 bp from pter
Size:
13,206 bases
Orientation:
Minus strand

Genomic View for TRIM11 Gene

Genes around TRIM11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM11 Gene

Proteins for TRIM11 Gene

  • Protein details for TRIM11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F44-TRI11_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM11
    Protein Accession:
    Q96F44
    Secondary Accessions:
    • A6NKE2
    • B2RB82
    • B3KUS3
    • B4DX88
    • Q5VSU1
    • Q8NCA6
    • Q9C022

    Protein attributes for TRIM11 Gene

    Size:
    468 amino acids
    Molecular mass:
    52774 Da
    Quaternary structure:
    • Binds cytoplasmic tail of integrin alpha-1. Interacts with the HN peptide (By similarity). Interacts with PHOX2B (By similarity). Interacts with PAX6 (By similarity). Interacts with MED15/ARC105; this interaction leads to MED15 ubiquitination and proteasomal degradation.
    SequenceCaution:
    • Sequence=AAH11629.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG53535.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG63300.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM11 Gene

Proteomics data for TRIM11 Gene at MOPED

Post-translational modifications for TRIM11 Gene

  • Ubiquitination at Lys 248 and Lys 258
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM11 Gene

Antibody Products

No data available for DME Specific Peptides for TRIM11 Gene

Domains & Families for TRIM11 Gene

Gene Families for TRIM11 Gene

Suggested Antigen Peptide Sequences for TRIM11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96F44

UniProtKB/Swiss-Prot:

TRI11_HUMAN :
  • The coiled-coil domain and the B30.2 domain are both necessary for interaction with HN and PAX6 (By similarity). They are also involved in MED15-binding.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Domain:
  • The coiled-coil domain and the B30.2 domain are both necessary for interaction with HN and PAX6 (By similarity). They are also involved in MED15-binding.
  • The B30.2 domain may be involved cellular protein quality control by promoting the degradation of insoluble ubiquitinated proteins.
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM11: view

Function for TRIM11 Gene

Molecular function for TRIM11 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.

Enzyme Numbers (IUBMB) for TRIM11 Gene

Gene Ontology (GO) - Molecular Function for TRIM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRIM11: view
genes like me logo Genes that share phenotypes with TRIM11: view

Animal Model Products

miRNA for TRIM11 Gene

miRTarBase miRNAs that target TRIM11

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM11 Gene

Localization for TRIM11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM11 Gene COMPARTMENTS Subcellular localization image for TRIM11 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for TRIM11 Gene

Pathways & Interactions for TRIM11 Gene

genes like me logo Genes that share pathways with TRIM11: view

UniProtKB/Swiss-Prot Q96F44-TRI11_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for TRIM11 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TRIM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0046597 negative regulation of viral entry into host cell IMP 18248090
GO:0046598 positive regulation of viral entry into host cell IMP 18248090
GO:0050768 negative regulation of neurogenesis IEA --
genes like me logo Genes that share ontologies with TRIM11: view

Drugs & Compounds for TRIM11 Gene

(3) Drugs for TRIM11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for TRIM11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with TRIM11: view

Transcripts for TRIM11 Gene

Unigene Clusters for TRIM11 Gene

Tripartite motif containing 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM11 Gene

No ASD Table

Relevant External Links for TRIM11 Gene

GeneLoc Exon Structure for
TRIM11
ECgene alternative splicing isoforms for
TRIM11

Expression for TRIM11 Gene

mRNA expression in normal human tissues for TRIM11 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM11 Gene

This gene is overexpressed in Brain - Cerebellum (x4.4) and Brain - Cerebellar Hemisphere (x4.0).

Protein differential expression in normal tissues from HIPED for TRIM11 Gene

This gene is overexpressed in Urine (27.5), Peripheral blood mononuclear cells (15.3), and Lymph node (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM11 Gene



SOURCE GeneReport for Unigene cluster for TRIM11 Gene Hs.13543

mRNA Expression by UniProt/SwissProt for TRIM11 Gene

Q96F44-TRI11_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with TRIM11: view

Protein tissue co-expression partners for TRIM11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TRIM11 Gene

Orthologs for TRIM11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM11 35
  • 94.73 (n)
  • 93.02 (a)
TRIM11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM11 36
  • 92 (a)
OneToOne
TRIM11 35
  • 87.32 (n)
  • 91.88 (a)
dog
(Canis familiaris)
Mammalia TRIM11 35
  • 87.89 (n)
  • 91.45 (a)
TRIM11 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim11 16
Trim11 35
  • 85.22 (n)
  • 89.72 (a)
Trim11 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM11 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 32 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia xnf7 35
Species with no ortholog for TRIM11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM11 Gene

ENSEMBL:
Gene Tree for TRIM11 (if available)
TreeFam:
Gene Tree for TRIM11 (if available)

Paralogs for TRIM11 Gene

genes like me logo Genes that share paralogs with TRIM11: view

Variants for TRIM11 Gene

Sequence variations from dbSNP and Humsavar for TRIM11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs508103 -- 228,399,151(+) GCTGG(A/G)AACCG intron-variant
rs513467 -- 228,399,734(+) GCCAG(C/T)TGATG intron-variant
rs578376 -- 228,394,282(+) TGCCT(C/T)CCCCA utr-variant-3-prime
rs505129 -- 228,399,128(+) ACCCC(C/T)GTCCA intron-variant
rs3180902 -- 228,394,146(+) CCCCT(C/T)CCATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRIM11 Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV Gain 17666407
nsv826908 CNV Gain 20364138
nsv523935 CNV Loss 19592680
nsv873255 CNV Loss 21882294
nsv827019 CNV Loss 20364138
dgv541n71 CNV Loss 21882294
nsv873270 CNV Loss 21882294
nsv517545 CNV Loss 19592680
nsv470780 CNV Loss 18288195
dgv542n71 CNV Loss 21882294
nsv873280 CNV Loss 21882294
nsv508697 CNV Loss 20534489

Variation tolerance for TRIM11 Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM11 Gene

HapMap Linkage Disequilibrium report
TRIM11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM11 Gene

Disorders for TRIM11 Gene

Relevant External Links for TRIM11

Genetic Association Database (GAD)
TRIM11
Human Genome Epidemiology (HuGE) Navigator
TRIM11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM11

No disorders were found for TRIM11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM11 Gene

Publications for TRIM11 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3 4 67
  2. Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene. (PMID: 25271088) Singh A. … Hauser E.R. (Eur. J. Hum. Genet. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The human antiviral factor TRIM11 is under the regulation of HIV-1 Vpr. (PMID: 25105968) Yuan T. … Yang R. (PLoS ONE 2014) 3
  5. TRIM11 negatively regulates IFNI^ production and antiviral activity by targeting TBK1. (PMID: 23675467) Lee Y. … Kwon K.S. (PLoS ONE 2013) 3

Products for TRIM11 Gene

Sources for TRIM11 Gene

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