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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM11 Gene

protein-coding   GIFtS: 55
GCID: GC01M228581

tripartite motif containing 11

(Previous name: tripartite motif-containing 11 )
 Explore 3 diseases affiliated with
TRIM11 via our new
 Human Malady Compendium 
Biological research products
for TRIM11
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Tripartite Motif Containing 111 2     RING Finger Protein 922 3
RNF921 2 3     E3 Ubiquitin-Protein Ligase TRIM112
BIA11 2     EC 6.3.2.-3
Tripartite Motif-Containing 111 2     Protein BIA13
Tripartite Motif-Containing Protein 112 3     

External Ids:    HGNC: 162811   Entrez Gene: 815592   Ensembl: ENSG000001543707   OMIM: 6078685   UniProtKB: Q96F443   

Export aliases for TRIM11 gene to outside databases

Previous GC identifers: GC01M227052 GC01M224319 GC01M224966 GC01M225556 GC01M225313 GC01M224888 GC01M226647 GC01M199095


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRIM11:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to
the nucleus and the cytoplasm. Its function has not been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TRI11_HUMAN, Q96F44
Function: E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including
insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to
proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity,
possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the
intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates
MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses.
Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression.
Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the
proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early
stages of the retroviral life cycle

Gene Wiki entry for TRIM11


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM11 gene promoter:
         Pax-5   NRSF form 1   MyoD   NRSF form 2   ITF-2   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM11 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.13   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42.13

TRIM11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM11 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M228581:  view genomic region     (about GC identifiers)

Start:
228,581,377 bp from pter      End:
228,594,541 bp from pter
Size:
13,165 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRI11_HUMAN, Q96F44 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM11  
Size: 468 amino acids; 52774 Da
Subunit: Binds cytoplasmic tail of integrin alpha-1. Interacts with the HN peptide (By similarity). Interacts with
PHOX2B (By similarity). Interacts with PAX6 (By similarity). Interacts with MED15/ARC105; this interaction leads to
MED15 ubiquitination and proteasomal degradation
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=AAH11629.1; Type=Erroneous initiation; Sequence=BAG53535.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAG63300.1; Type=Erroneous initiation; Note=Translation N-terminally
extended;
Secondary accessions: A6NKE2 B2RB82 B3KUS3 B4DX88 Q5VSU1 Q8NCA6 Q9C022
Alternative splicing: 3 isoforms:  Q96F44-1   Q96F44-2   Q96F44-3   (May be due to competing acceptor splice site. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIM11: NX_Q96F44

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96F44

  • TRIM11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_660215.1  
    ENSEMBL proteins: 
     ENSP00000284551   ENSP00000355660  
    Reactome Protein details: Q96F44
    Human Recombinant Protein Products: 
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    Uscn Proteins for TRIM11

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--


    TRIM11 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TRIM11


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TRIM11 for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR006574 PRY
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q96F44

    ProtoNet protein and cluster: Q96F44

    4 Blocks protein families:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: TRI11_HUMAN, Q96F44
    Domain: The coiled-coil domain and the B30.2 domain are both necessary for interaction with HN and PAX6 (By
    similarity). They are also involved in MED15-binding
    Domain: The B30.2 domain may be involved cellular protein quality control by promoting the degradation of insoluble
    ubiquitinated proteins (By similarity)
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TRI11_HUMAN, Q96F44
    Function: E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including
    insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to
    proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity,
    possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the
    intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates
    MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses.
    Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression.
    Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the
    proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early
    stages of the retroviral life cycle

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
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    hsa-miR-9
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    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0008134transcription factor binding IEA--
    GO:0008270zinc ion binding IEA--


    TRIM11 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for TRIM11:
     Increased cell number in G1, s  Increased viability after born 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation1.00
    Polyubiquitination of substrate0.75
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System1.00
    Adaptive Immune System0.59

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for TRIM11
        Antigen processing: Ubiquitination & Proteasome degradation
    Polyubiquitination of substrate
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    UniProtKB/Swiss-Prot: TRI11_HUMAN, Q96F44
    Pathway: Protein modification; protein ubiquitination


    TRIM11 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRIM11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/15 Interacting proteins for TRIM11 (Q96F442, 3 ENSP000002845514) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED15Q96RN52, 3, ENSP000002632054MINT-2880043 MINT-2880087 MINT-2880111 MINT-2880139 MINT-2880064 I2D: score=3 STRING: ENSP00000263205
    TRIM29Q141343, ENSP000003431294I2D: score=2 STRING: ENSP00000343129
    PAX6P263673, ENSP000003684014I2D: score=2 STRING: ENSP00000368401
    TRIM27P143733, ENSP000003664044I2D: score=2 STRING: ENSP00000366404
    HAX1O001653I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009615response to virus ----
    GO:0016567protein ubiquitination ----
    GO:0045892negative regulation of transcription, DNA-dependent IEA--
    GO:0050768negative regulation of neurogenesis IEA--
    GO:0051607defense response to virus IEA--


    TRIM11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM11

    4 HMDB Compounds for TRIM11    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about TRIM11 / TRI11 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRIM11 gene: 
    NM_145214.2  

    Unigene Cluster for TRIM11:

    Tripartite motif containing 11
    Hs.13543  [show with all ESTs]
    Unigene Representative Sequence: AK226119
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284551(uc001hss.3 uc010pvx.2) ENST00000493030 ENST00000460651
    ENST00000475775 ENST00000366699(uc001hst.1)

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate TRIM11:
    hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidTRIM11 3' UTR sequence
    Inhib. RNA
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM11

    Additional cDNA sequence: 

    AF220125.1 AF327056.1 AK074866.1 AK097825.1 AK226119.1 AK301859.1 AK314539.1 AL360165.1 
    BC011629.2 BC069227.1 

    8 DOTS entries:

    DT.114925  DT.91842622  DT.95367902  DT.100784966  DT.92424876  DT.95266896  DT.99994522  DT.108027 

    24/153 AceView cDNA sequences (see all 153):

    AI885021 BM983424 NM_145214 AA974506 CA867291 H47693 AW402527 BF059582 
    BM981378 AK074866 AI027548 CK903162 BU951746 AI468762 AW298403 CR606885 
    BP381300 CB130364 BM561600 BU956088 CK903161 BM670456 BC069227 AI743182 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGCCATTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TRIM11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM11

    SOURCE GeneReport for Unigene cluster: Hs.13543

    UniProtKB/Swiss-Prot: TRI11_HUMAN, Q96F44
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including TRIM11: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM11 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    African clawed frog
    (Xenopus laevis)
    Amphibia xnf72 X.laeivs xnf7 protein mRNA, complete cds 75(n)    M63705.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trim476
    tripartite motif containing 47
    25(a)
    possible ortholog
    10(26752552-26762609)


    ENSEMBL Gene Tree for TRIM11 (if available)
    TreeFam Gene Tree for TRIM11 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM11 gene
    TRIM42  TRIM72  TRIM262  TRIM392  TRIM342  TRIML12  TRIM272  TRIM582  
    TRIM682  TRIM102  TRIM152  TRIM602  TRIM222  TRIM172  TRIM52  TRIM62  
    TRIM6-TRIM342  TRIM212  TRIM382  TRIM39-RPP212  
    18/36 SIMAP similar genes for TRIM11 using alignment to 1 protein entry:     TRI11_HUMAN(see all similar genes):
    BTN1A1    TRIM39R    TRIM39    TRIM27    TRIM17    TRIM21
    DKFZp666N1710    TRIM58    TRIM68    TRIML1    TRIM41    TRIM6
    RFPL4B    TRIM38    TRIM43    TRIM43B    TRIM5    TRIM60

    TRIM11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/294 NCBI SNPs in TRIM11 are shown (see all 294    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1463764021,2
    C,--228580906(+) AAAAC-/AACA  
            
    AACAA
    1 -- ds50010--------
    rs1845599891,2
    --228581003(+) AACTGA/CTGATC 1 -- ds50010--------
    rs1406039891,2
    --228581020(+) AACATA/GGTATT 1 -- ds50010--------
    rs759283791,2
    --228581036(+) ATGCCC/TCCCCA 1 -- ds50010--------
    rs1453627541,2
    --228581150(+) TATCTC/TGAAAA 1 -- ds50010--------
    rs1491879241,2
    --228581342(+) CGCTAC/TTGTTC 1 -- ds50010--------
    rs1469653921,2
    --228581438(+) GAGGGA/GTAAAG 1 -- ut310--------
    rs1883961361,2
    --228581484(+) CAAACC/TCAACA 1 -- ut310--------
    rs1380108591,2
    --228581576(+) GCCGGC/TGGCCA 1 -- ut310--------
    rs1930592481,2
    --228581704(+) AGAACC/GTGGGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TRIM11 (228581377 - 228594541 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for TRIM11
         4 CNVs: 48265 6812 48267 48266

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TRIM11 for disorders           About GeneDecksing

    OMIM gene information: 607868    OMIM disorders: --

    3 diseases for TRIM11:    About MalaCards
    pthirus pubis infestation    alzheimer's disease    leukemia

    1 disease from the University of Copenhagen DISEASES database for TRIM11:
    Pthirus pubis infestation
    Human Genome Epidemiology (HuGE) Navigator: TRIM11 (1 document)

    Export disorders for TRIM11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM11 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with TRIM11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2, 3 Reymond A.... Ballabio A. (2001)
    2. TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. (PubMed id 18248090)1, 2 Uchil P.D....Mothes W. (2008)
    3. TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system. (PubMed id 16904669)1, 2 Ishikawa H....Takahashi N. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    7. The E3 ubiquitin ligase TRIM11 mediates the degradatio n of congenital central hypoventilation syndrome-associated polyalanine-expanded PHOX2B. (PubMed id 22307522)1 Parodi S....Ceccherini I. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Functional interactions between ubiquitin E2 enzymes a nd TRIM proteins. (PubMed id 21143188)1 Napolitano L.M....Meroni G. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81559 HGNC: 16281 AceView: TRIM11 Ensembl:ENSG00000154370 euGenes: HUgn81559
    ECgene: TRIM11 H-InvDB: TRIM11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRIM11 gene:
    Search GeneIP for patents involving TRIM11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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