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TRIM11 Gene

protein-coding   GIFtS: 58
GCID: GC01M228581

Tripartite Motif Containing 11

(Previous name: tripartite motif-containing 11)
  See TRIM11-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 111 2     BIA12
Tripartite Motif-Containing 111 2     E3 Ubiquitin-Protein Ligase TRIM112
Tripartite Motif-Containing Protein 112 3     EC 6.3.2.-3
RNF922 3     Protein BIA13
RING Finger Protein 922 3     

External Ids:    HGNC: 162811   Entrez Gene: 815592   Ensembl: ENSG000001543707   OMIM: 6078685   UniProtKB: Q96F443   

Export aliases for TRIM11 gene to outside databases

Previous GC identifers: GC01M227052 GC01M224319 GC01M224966 GC01M225556 GC01M225313 GC01M224888 GC01M226647 GC01M199095


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIM11 Gene:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes
to the nucleus and the cytoplasm. Its function has not been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRIM11 Gene:
TRIM11 (tripartite motif containing 11) is a protein-coding gene. Diseases associated with TRIM11 include congenital central hypoventilation syndrome, and central hypoventilation syndrome. GO annotations related to this gene include ubiquitin-protein ligase activity and transcription factor binding. An important paralog of this gene is TRIM7.

UniProtKB/Swiss-Prot: TRI11_HUMAN, Q96F44
Function: E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including
insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination
leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6
transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May
contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the
proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute
to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus
infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3
ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the
TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle

Gene Wiki entry for TRIM11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM11 gene promoter:
         Pax-5   NRSF form 1   MyoD   NRSF form 2   ITF-2   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM11 promoter sequence
   Search Chromatin IP Primers for TRIM11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.13   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42.13

TRIM11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM11 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M228581:  view genomic region     (about GC identifiers)

Start:
228,581,374 bp from pter      End:
228,594,541 bp from pter
Size:
13,168 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TRI11_HUMAN, Q96F44 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM11  
Size: 468 amino acids; 52774 Da
Subunit: Binds cytoplasmic tail of integrin alpha-1. Interacts with the HN peptide (By similarity). Interacts with
PHOX2B (By similarity). Interacts with PAX6 (By similarity). Interacts with MED15/ARC105; this interaction leads
to MED15 ubiquitination and proteasomal degradation
Sequence caution: Sequence=AAH11629.1; Type=Erroneous initiation; Sequence=BAG53535.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAG63300.1; Type=Erroneous initiation; Note=Translation
N-terminally extended;
Secondary accessions: A6NKE2 B2RB82 B3KUS3 B4DX88 Q5VSU1 Q8NCA6 Q9C022
Alternative splicing: 3 isoforms:  Q96F44-1   Q96F44-2   Q96F44-3   (May be due to competing acceptor splice site. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIM11: NX_Q96F44

Explore proteomics data for TRIM11 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys248, Lys258
  • Modification sites at PhosphoSitePlus

  • See TRIM11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_660215.1  
    ENSEMBL proteins: 
     ENSP00000473360   ENSP00000284551   ENSP00000473574   ENSP00000355660   ENSP00000473579  
    Reactome Protein details: Q96F44

    TRIM11 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TRIM11

     
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    antibodies-online proteins for TRIM11 (6 products) 

     
    antibodies-online peptides for TRIM11

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    antibodies-online kits for TRIM11 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 10):
     IPR006574 PRY
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q96F44

    ProtoNet protein and cluster: Q96F44

    4 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: TRI11_HUMAN, Q96F44
    Domain: The coiled-coil domain and the B30.2 domain are both necessary for interaction with HN and PAX6 (By
    similarity). They are also involved in MED15-binding
    Domain: The B30.2 domain may be involved cellular protein quality control by promoting the degradation of
    insoluble ubiquitinated proteins (By similarity)
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with TRIM11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI11_HUMAN, Q96F44
    Function: E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including
    insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination
    leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6
    transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May
    contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the
    proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute
    to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus
    infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3
    ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the
    TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding IPI16904669
    GO:0008134transcription factor binding IEA--
    GO:0008270zinc ion binding IEA--
    GO:0019904protein domain specific binding IEA--
         
    Find genes that share ontologies with TRIM11           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRIM11:
     Increased cell number in G1, s  Increased viability after born 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TRIM11

    miRNA
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    miRTarBase miRNAs that target TRIM11:
    hsa-mir-17-5p (MIRT050803)

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    1 qRT-PCR Assays for microRNA that regulate TRIM11:
    hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidTRIM11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRIM11

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRI11_HUMAN, Q96F44: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with TRIM11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRIM11 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84


    Find genes that share SuperPaths with TRIM11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for TRIM11
        Antigen processing: Ubiquitination & Proteasome degradation


    UniProtKB/Swiss-Prot: TRI11_HUMAN, Q96F44
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM11: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRIM11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for TRIM11 (Q96F441, 2, 3 ENSP000002845514) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED15Q96RN51, 2, 3, ENSP000002632054EBI-851809,EBI-394506 MINT-2880043 MINT-2880087 MINT-2880111 MINT-2880139 MINT-2880064 I2D: score=3 STRING: ENSP00000263205
    TRIM27P143733, ENSP000003664044I2D: score=2 STRING: ENSP00000366404
    ENSG00000215641P143733I2D: score=2 
    ENSG00000229006P143733I2D: score=2 
    ENSG00000234495P143733I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032897negative regulation of viral transcription IDA18248090
    GO:0045087innate immune response IMP18248090
    GO:0045892negative regulation of transcription, DNA-templated IEA--
    GO:0046597negative regulation of viral entry into host cell IMP18248090
    GO:0046598positive regulation of viral entry into host cell IMP18248090

    Find genes that share ontologies with TRIM11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM11 (TRI11)

    4 HMDB Compounds for TRIM11    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRIM11 gene: 
    NM_145214.2  

    Unigene Cluster for TRIM11:

    Tripartite motif containing 11
    Hs.13543  [show with all ESTs]
    Unigene Representative Sequence: AK226119
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493030 ENST00000284551(uc001hss.3 uc010pvx.2) ENST00000460651
    ENST00000602582 ENST00000475775 ENST00000366699(uc001hst.1) ENST00000602308

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate TRIM11:
    hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidTRIM11 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat TRIM11

    Additional mRNA sequence: 

    AF220125.1 AF327056.1 AK074866.1 AK097825.1 AK226119.1 AK301859.1 AK314539.1 AL360165.1 
    BC011629.2 BC069227.1 

    8 DOTS entries:

    DT.114925  DT.91842622  DT.95367902  DT.100784966  DT.92424876  DT.95266896  DT.99994522  DT.108027 

    Selected AceView cDNA sequences (see all 153):

    BM981378 BC069227 BM561600 CA867291 AW402527 AI468762 H47693 AI885021 
    CK903162 AI027548 BM670456 CR606885 BF059582 AW298403 BP381300 BU951746 
    CB130364 BU956088 AK074866 CK903161 AA974506 NM_145214 BM983424 BE263471 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCCATTGG
    TRIM11 Expression
    About this image


    TRIM11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    TRIM11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.13543

    UniProtKB/Swiss-Prot: TRI11_HUMAN, Q96F44
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM11: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM11 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim111 , 5 tripartite motif-containing 111, 5 85.22(n)1
    89.72(a)1
      11 (36.40 cM)5
    940911  NM_053168.11  NP_444398.11 
     589780935 
    African clawed frog
    (Xenopus laevis)
    Amphibia xnf72 X.laeivs xnf7 protein mRNA, complete cds 75(n)    M63705.1 


    ENSEMBL Gene Tree for TRIM11 (if available)
    TreeFam Gene Tree for TRIM11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM11 gene
    TRIM72  TRIM42  TRIM392  TRIM342  TRIML12  TRIM272  TRIM582  TRIM682  
    TRIM602  TRIM222  TRIM172  TRIM52  TRIM62  TRIM6-TRIM342  TRIM212  TRIM382  
    TRIM39-RPP212  
    Selected SIMAP similar genes for TRIM11 using alignment to 4 protein entries:     TRI11_HUMAN (see all proteins) (see all similar genes):
    BTN3A3    ERMAP    BTN2A2    BTN1A1    TRIM39R    TRIM21
    BT3.3    TRIM39    TRIM27    MEFV    TRIM17    TRIM68
    TRIML1    TRIM58    BTNL9    DKFZp666N1710    TRIM41    TRIM69

    Find genes that share paralogs with TRIM11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM11 (see all 371)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1463764021,2
    C--228580906(+) AAAAC-/AACA  
            
    AACAA
    1 -- ds50010--------
    rs1845599891,2
    --228581003(+) AACTGA/CTGATC 1 -- ds50010--------
    rs1406039891,2
    --228581020(+) AACATA/GGTATT 1 -- ds50010--------
    rs759283791,2
    --228581036(+) ATGCCC/TCCCCA 1 -- ds50010--------
    rs1453627541,2
    --228581150(+) TATCTC/TGAAAA 1 -- ds50010--------
    rs1491879241,2
    --228581342(+) CGCTAC/TTGTTC 1 -- ds50010--------
    rs741446191,2
    C--228581436(+) CAGAGG/AGGTAA 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs1469653921,2
    C--228581438(+) GAGGGA/GTAAAG 1 -- ut310--------
    rs1883961361,2
    --228581484(+) CAAACC/TCAACA 1 -- ut310--------
    rs1380108591,2
    --228581576(+) GCCGGC/TGGCCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TRIM11 (228581374 - 228594541 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TRIM11 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873280CNV Loss21882294
    nsv827019CNV Loss20364138
    nsv508697CNV Loss20534489
    nsv523935CNV Loss19592680
    nsv517545CNV Loss19592680
    nsv873270CNV Loss21882294
    nsv470780CNV Loss18288195
    nsv873255CNV Loss21882294
    dgv542n71CNV Loss21882294
    dgv541n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607868    OMIM disorders: --

    2 diseases for TRIM11:    
    About MalaCards
    congenital central hypoventilation syndrome    central hypoventilation syndrome


    Find genes that share disorders with TRIM11           About GenesLikeMe

    Genetic Association Database (GAD): TRIM11
    Human Genome Epidemiology (HuGE) Navigator: TRIM11 (1 document)

    Export disorders for TRIM11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM11 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with TRIM11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2, 3 Reymond A.... Ballabio A. (EMBO J. 2001)
    2. TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. (PubMed id 18248090)1, 2 Uchil P.D.... Mothes W. (PLoS Pathog. 2008)
    3. Candidate-gene testing for orphan limb-girdle muscular dystrophies. (PubMed id 19472918)1, 4 Aurino S....Nigro V. (Acta Myol 2008)
    4. TRIM11 binds to and destabilizes a key component of the activator- mediated cofactor complex (ARC105) through the ubiquitin-proteasome system. (PubMed id 16904669)1, 2 Ishikawa H.... Takahashi N. (FEBS Lett. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. TRIM11 negatively regulates IFNI^ production and antiviral activity by targeting TBK1. (PubMed id 23675467)1 Lee Y....Kwon K.S. (PLoS ONE 2013)
    8. TRIM11 is overexpressed in high-grade gliomas and promotes proliferation, invasion, migration and glial tumor growth. (PubMed id 23178488)1 Di K....Bota D.A. (Oncogene 2013)
    9. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    10. The E3 ubiquitin ligase TRIM11 mediates the degradation of congenital central hypoventilation syndrome-associated polyalanine-expanded PHOX2B. (PubMed id 22307522)1 Parodi S....Ceccherini I. (J. Mol. Med. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81559 HGNC: 16281 AceView: TRIM11 Ensembl:ENSG00000154370 euGenes: HUgn81559
    ECgene: TRIM11 H-InvDB: TRIM11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRIM11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM11 gene:
    Search GeneIP for patents involving TRIM11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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