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Aliases for TRIM11 Gene

Aliases for TRIM11 Gene

  • Tripartite Motif Containing 11 2 3 5
  • Tripartite Motif-Containing Protein 11 3 4
  • RING Finger Protein 92 3 4
  • RNF92 3 4
  • E3 Ubiquitin-Protein Ligase TRIM11 3
  • Tripartite Motif-Containing 11 2
  • Protein BIA1 4
  • EC 6.3.2.- 4
  • BIA1 3

External Ids for TRIM11 Gene

Previous GeneCards Identifiers for TRIM11 Gene

  • GC01M227052
  • GC01M224319
  • GC01M224966
  • GC01M225556
  • GC01M225313
  • GC01M224888
  • GC01M226647
  • GC01M228581
  • GC01M199095

Summaries for TRIM11 Gene

Entrez Gene Summary for TRIM11 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM11 Gene

TRIM11 (Tripartite Motif Containing 11) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is TRIM17.

UniProtKB/Swiss-Prot for TRIM11 Gene

  • E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.

Gene Wiki entry for TRIM11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM11 Gene

Genomics for TRIM11 Gene

Regulatory Elements for TRIM11 Gene

Enhancers for TRIM11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F228373 1 Ensembl ENCODE 16.2 +31.8 31844 2.1 BCOR SMARCA5 CBX3 ESRRA KLF17 ZMYM3 NR2F2 ZNF121 GTF3C2 GLIS2 CICP26 TRIM11 OBSCN MIR6742 ENSG00000231563 RPL23AP15 HIST3H2A HIST3H2BB C1orf145 ENSG00000269890
GH01F228445 1.5 FANTOM5 Ensembl ENCODE 13.1 -39.2 -39211 1.1 USF1 BHLHE40 USF2 MAX BMI1 ZBTB7A ZBTB40 SREBF1 RAD51 ZBTB33 TRIM17 OBSCN TRIM11 ENSG00000231563 MIR6742 C1orf145 WNT3A GJC2 HIST3H2A RPL23AP15
GH01F228377 0.6 Ensembl ENCODE 12 +28.2 28176 1.8 SIN3A ZNF2 ZNF121 GLIS2 KLF7 SP3 TSHZ1 REST ZNF518A ZNF623 PRSS38 LOC100421842 ENSG00000233920 MIR6742 ENSG00000231563 TRIM11 RPL23AP15 HIST3H2A HIST3H2BB C1orf145
GH01F228282 0.4 ENCODE 11.2 +124.3 124343 0.2 PRDM10 ZBTB33 OBSCN ENSG00000231563 MIR6742 TRIM11 ENSG00000269934 GC01P228299
GH01F228275 0.9 ENCODE 11.2 +130.8 130816 2.0 HDGF ATF1 PKNOX1 ARNT CREB3L1 SIN3A GLIS2 GATA2 CBX5 KLF13 OBSCN C1orf145 ENSG00000269934 ENSG00000231563 MIR6742 TRIM11 RPL23AP15 HIST3H2A HIST3H2BB ENSG00000270110
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TRIM11 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000554455 177 2601 ATF1 CREB3L1 ZNF133 ARID4B SIN3A ZNF48 YY1 GLIS2 ELK1 ZNF207

Genomic Location for TRIM11 Gene

Chromosome:
1
Start:
228,393,672 bp from pter
End:
228,406,877 bp from pter
Size:
13,206 bases
Orientation:
Minus strand

Genomic View for TRIM11 Gene

Genes around TRIM11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM11 Gene

Proteins for TRIM11 Gene

  • Protein details for TRIM11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F44-TRI11_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM11
    Protein Accession:
    Q96F44
    Secondary Accessions:
    • A6NKE2
    • B2RB82
    • B3KUS3
    • B4DX88
    • Q5VSU1
    • Q8NCA6
    • Q9C022

    Protein attributes for TRIM11 Gene

    Size:
    468 amino acids
    Molecular mass:
    52774 Da
    Quaternary structure:
    • Binds cytoplasmic tail of integrin alpha-1. Interacts with the HN peptide (By similarity). Interacts with PHOX2B (By similarity). Interacts with PAX6 (By similarity). Interacts with MED15/ARC105; this interaction leads to MED15 ubiquitination and proteasomal degradation.
    • Binds cytoplasmic tail of integrin alpha-1. Interacts with the HN peptide (By similarity). Interacts with PHOX2B (By similarity). Interacts with PAX6 (By similarity). Interacts with MED15/ARC105; this interaction leads to MED15 ubiquitination and proteasomal degradation.
    SequenceCaution:
    • Sequence=AAH11629.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG53535.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG63300.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM11 Gene

Post-translational modifications for TRIM11 Gene

  • Ubiquitination at Lys 248 and Lys 258
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM11 Gene

No data available for DME Specific Peptides for TRIM11 Gene

Domains & Families for TRIM11 Gene

Gene Families for TRIM11 Gene

Suggested Antigen Peptide Sequences for TRIM11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96F44

UniProtKB/Swiss-Prot:

TRI11_HUMAN :
  • The coiled-coil domain and the B30.2 domain are both necessary for interaction with HN and PAX6 (By similarity). They are also involved in MED15-binding.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Domain:
  • The coiled-coil domain and the B30.2 domain are both necessary for interaction with HN and PAX6 (By similarity). They are also involved in MED15-binding.
  • The B30.2 domain may be involved cellular protein quality control by promoting the degradation of insoluble ubiquitinated proteins.
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM11: view

Function for TRIM11 Gene

Molecular function for TRIM11 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.

Enzyme Numbers (IUBMB) for TRIM11 Gene

Gene Ontology (GO) - Molecular Function for TRIM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16904669
GO:0008134 transcription factor binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with TRIM11: view
genes like me logo Genes that share phenotypes with TRIM11: view

Animal Model Products

miRNA for TRIM11 Gene

miRTarBase miRNAs that target TRIM11

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM11 Gene

Localization for TRIM11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM11 Gene COMPARTMENTS Subcellular localization image for TRIM11 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for TRIM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA,IDA 18248090
genes like me logo Genes that share ontologies with TRIM11: view

Pathways & Interactions for TRIM11 Gene

genes like me logo Genes that share pathways with TRIM11: view

UniProtKB/Swiss-Prot Q96F44-TRI11_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for TRIM11 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TRIM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0032897 negative regulation of viral transcription IDA 18248090
GO:0045087 innate immune response IMP 18248090
GO:0045892 negative regulation of transcription, DNA-templated IEA --
GO:0046597 negative regulation of viral entry into host cell IMP 18248090
genes like me logo Genes that share ontologies with TRIM11: view

Drugs & Compounds for TRIM11 Gene

(3) Drugs for TRIM11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for TRIM11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with TRIM11: view

Transcripts for TRIM11 Gene

Unigene Clusters for TRIM11 Gene

Tripartite motif containing 11:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM11 Gene

No ASD Table

Relevant External Links for TRIM11 Gene

GeneLoc Exon Structure for
TRIM11
ECgene alternative splicing isoforms for
TRIM11

Expression for TRIM11 Gene

mRNA expression in normal human tissues for TRIM11 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM11 Gene

This gene is overexpressed in Brain - Cerebellum (x4.4) and Brain - Cerebellar Hemisphere (x4.0).

Protein differential expression in normal tissues from HIPED for TRIM11 Gene

This gene is overexpressed in Urine (27.5), Peripheral blood mononuclear cells (15.3), and Lymph node (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM11 Gene



Protein tissue co-expression partners for TRIM11 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM11 Gene:

TRIM11

SOURCE GeneReport for Unigene cluster for TRIM11 Gene:

Hs.13543

mRNA Expression by UniProt/SwissProt for TRIM11 Gene:

Q96F44-TRI11_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with TRIM11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TRIM11 Gene

Orthologs for TRIM11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM11 34 35
  • 94.73 (n)
dog
(Canis familiaris)
Mammalia TRIM11 34 35
  • 87.89 (n)
cow
(Bos Taurus)
Mammalia TRIM11 34 35
  • 87.32 (n)
mouse
(Mus musculus)
Mammalia Trim11 34 16 35
  • 85.22 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIM11 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 44 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia xnf7 34
Species where no ortholog for TRIM11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM11 Gene

ENSEMBL:
Gene Tree for TRIM11 (if available)
TreeFam:
Gene Tree for TRIM11 (if available)

Paralogs for TRIM11 Gene

Variants for TRIM11 Gene

Sequence variations from dbSNP and Humsavar for TRIM11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs101235 -- 228,398,549(-) CTCGA(C/T)GTCCT intron-variant, upstream-variant-2KB
rs10916308 -- 228,406,868(+) TGTGt(G/T)ttttt upstream-variant-2KB, utr-variant-5-prime
rs111313864 -- 228,407,158(+) AGGAG(C/G)GATGG downstream-variant-500B, upstream-variant-2KB
rs111376409 -- 228,395,773(+) CCTCC(C/T)GCCTG intron-variant
rs111487001 -- 228,394,993(+) TTGCC(C/T)GCGGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TRIM11 Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV gain 17666407
nsv1013500 CNV gain 25217958
nsv470780 CNV loss 18288195
nsv508697 CNV deletion 20534489
nsv517545 CNV loss 19592680
nsv523935 CNV loss 19592680
nsv549295 CNV loss 21841781
nsv549296 CNV gain 21841781
nsv826908 CNV gain 20364138
nsv827019 CNV loss 20364138
nsv952141 CNV deletion 24416366

Variation tolerance for TRIM11 Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM11 Gene

Human Gene Mutation Database (HGMD)
TRIM11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM11 Gene

Disorders for TRIM11 Gene

Relevant External Links for TRIM11

Genetic Association Database (GAD)
TRIM11
Human Genome Epidemiology (HuGE) Navigator
TRIM11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM11

No disorders were found for TRIM11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM11 Gene

Publications for TRIM11 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3 4 64
  2. TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. (PMID: 18248090) Uchil P.D. … Mothes W. (PLoS Pathog. 2008) 3 4 64
  3. Candidate-gene testing for orphan limb-girdle muscular dystrophies. (PMID: 19472918) Aurino S. … Nigro V. (Acta Myol 2008) 3 46 64
  4. TRIM11 binds to and destabilizes a key component of the activator- mediated cofactor complex (ARC105) through the ubiquitin-proteasome system. (PMID: 16904669) Ishikawa H. … Takahashi N. (FEBS Lett. 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for TRIM11 Gene

Sources for TRIM11 Gene

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