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Aliases for TRIM10 Gene

Aliases for TRIM10 Gene

  • Tripartite Motif Containing 10 2 3
  • RFB30 3 4 6
  • RNF9 3 4 6
  • Tripartite Motif-Containing 10 2 3
  • B30-RING Finger Protein 3 4
  • HERF1 3 6
  • Tripartite Motif-Containing Protein 10 3
  • Hematopoietic RING Finger 1 3
  • Tripartite Motif Protein 10 3
  • Ring Finger Protein 9 3
  • RING Finger Protein 9 4
  • Zn-Finger Protein 3

External Ids for TRIM10 Gene

Previous HGNC Symbols for TRIM10 Gene

  • RNF9

Previous GeneCards Identifiers for TRIM10 Gene

  • GC06M030204
  • GC06M029890
  • GC06M030225
  • GC06M030227
  • GC06M030119
  • GC06M029918

Summaries for TRIM10 Gene

Entrez Gene Summary for TRIM10 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM10 Gene

TRIM10 (Tripartite Motif Containing 10) is a Protein Coding gene. Diseases associated with TRIM10 include esophageal cancer. An important paralog of this gene is TRIM50.

UniProtKB/Swiss-Prot for TRIM10 Gene

  • Seems to play an important role in erythropoiesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM10 Gene

Genomics for TRIM10 Gene

Regulatory Elements for TRIM10 Gene

Genomic Location for TRIM10 Gene

Start:
30,151,945 bp from pter
End:
30,160,934 bp from pter
Size:
8,990 bases
Orientation:
Minus strand

Genomic View for TRIM10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TRIM10 Gene

  • Protein details for TRIM10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UDY6-TRI10_HUMAN
    Recommended name:
    Tripartite motif-containing protein 10
    Protein Accession:
    Q9UDY6
    Secondary Accessions:
    • A6NF84
    • Q5SRJ5
    • Q5SRK8
    • Q86Z08
    • Q96QB6
    • Q9C023
    • Q9C024

    Protein attributes for TRIM10 Gene

    Size:
    481 amino acids
    Molecular mass:
    55037 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIM10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM10 Gene

Proteomics data for TRIM10 Gene at MOPED

Post-translational modifications for TRIM10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM10 Gene

Domains for TRIM10 Gene

Gene Families for TRIM10 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Suggested Antigen Peptide Sequences for TRIM10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UDY6

UniProtKB/Swiss-Prot:

TRI10_HUMAN :
  • Q9UDY6
Domain:
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM10: view

Function for TRIM10 Gene

Molecular function for TRIM10 Gene

UniProtKB/Swiss-Prot Function: Seems to play an important role in erythropoiesis.

Gene Ontology (GO) - Molecular Function for TRIM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM10: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRIM10 Gene

Localization for TRIM10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM10 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM10 Gene COMPARTMENTS Subcellular localization image for TRIM10 gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for TRIM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with TRIM10: view

Pathways for TRIM10 Gene

SuperPathways for TRIM10 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TRIM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0030218 erythrocyte differentiation IEA --
GO:0045087 innate immune response IEA --
GO:0046597 negative regulation of viral entry into host cell IEA --
genes like me logo Genes that share ontologies with TRIM10: view

No data available for Pathways by source for TRIM10 Gene

Transcripts for TRIM10 Gene

Unigene Clusters for TRIM10 Gene

Tripartite motif containing 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM10

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TRIM10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM10 Gene

No ASD Table

Relevant External Links for TRIM10 Gene

GeneLoc Exon Structure for
TRIM10
ECgene alternative splicing isoforms for
TRIM10

Expression for TRIM10 Gene

mRNA expression in normal human tissues for TRIM10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM10 Gene

This gene is overexpressed in Whole Blood (15.7), Liver (8.8), Colon - Transverse (8.6), and Kidney - Cortex (7.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TRIM10 Gene

SOURCE GeneReport for Unigene cluster for TRIM10 Gene Hs.709483

genes like me logo Genes that share expressions with TRIM10: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TRIM10 Gene

Orthologs for TRIM10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM10 35
  • 98.82 (n)
  • 98.34 (a)
TRIM10 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM10 35
  • 86.56 (n)
  • 85.86 (a)
TRIM10 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM10 35
  • 82.7 (n)
  • 82.56 (a)
TRIM10 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim10 35
  • 82.99 (n)
  • 84.37 (a)
Trim10 16
Trim10 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM10 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim10 35
  • 82.01 (n)
  • 83.33 (a)
Species with no ortholog for TRIM10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM10 Gene

ENSEMBL:
Gene Tree for TRIM10 (if available)
TreeFam:
Gene Tree for TRIM10 (if available)

Paralogs for TRIM10 Gene

Selected SIMAP similar genes for TRIM10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM10: view

Variants for TRIM10 Gene

Sequence variations from dbSNP and Humsavar for TRIM10 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1967 -- 30,157,760(+) CTAGC(C/T)CTGGA intron-variant
rs1970 -- 30,157,766(+) CTGGA(C/T)AGGAA intron-variant
rs10733 -- 30,152,019(+) taaaa(A/G)aaaaa utr-variant-3-prime
rs730763 -- 30,156,408(+) ACCCT(C/T)CCCCA intron-variant
rs733888 -- 30,157,066(-) CATTT(C/T)TGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM10 Gene

Variant ID Type Subtype PubMed ID
esv2731777 CNV Deletion 23290073

Relevant External Links for TRIM10 Gene

HapMap Linkage Disequilibrium report
TRIM10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM10 Gene

Disorders for TRIM10 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TRIM10 Gene including...

Search for TRIM10 Gene in MalaCards »

Relevant External Links for TRIM10

Genetic Association Database (GAD)
TRIM10
Human Genome Epidemiology (HuGE) Navigator
TRIM10
genes like me logo Genes that share disorders with TRIM10: view

No data available for UniProtKB/Swiss-Prot for TRIM10 Gene

Publications for TRIM10 Gene

  1. Cloning, structural analysis, and mapping of the B30 and B7 multigenic families to the major histocompatibility complex (MHC) and other chromosomal regions. (PMID: 9271628) Henry J. … Pontarotti P. (Immunogenetics 1997) 2 3 4
  2. HERF1, a novel hematopoiesis-specific RING finger protein, is required for terminal differentiation of erythroid cells. (PMID: 10207104) Harada H. … Downing J.R. (Mol. Cell. Biol. 1999) 2 3
  3. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 3 4
  4. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. (PMID: 16702430) Shiina T. … Bahram S. (Genetics 2006) 3 4
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 48

Products for TRIM10 Gene

Sources for TRIM10 Gene

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