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Aliases for TRIM10 Gene

Aliases for TRIM10 Gene

  • Tripartite Motif Containing 10 2 3 5
  • B30-RING Finger Protein 3 4
  • RFB30 3 4
  • RNF9 3 4
  • Tripartite Motif-Containing Protein 10 3
  • Tripartite Motif-Containing 10 2
  • Hematopoietic RING Finger 1 3
  • Tripartite Motif Protein 10 3
  • Ring Finger Protein 9 3
  • RING Finger Protein 9 4
  • Zn-Finger Protein 3
  • HERF1 3

External Ids for TRIM10 Gene

Previous HGNC Symbols for TRIM10 Gene

  • RNF9

Previous GeneCards Identifiers for TRIM10 Gene

  • GC06M030204
  • GC06M029890
  • GC06M030225
  • GC06M030227
  • GC06M030119
  • GC06M029918

Summaries for TRIM10 Gene

Entrez Gene Summary for TRIM10 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM10 Gene

TRIM10 (Tripartite Motif Containing 10) is a Protein Coding gene. Among its related pathways are Interferon gamma signaling and Innate Immune System. An important paralog of this gene is TRIM15.

UniProtKB/Swiss-Prot for TRIM10 Gene

  • Seems to play an important role in erythropoiesis.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM10 Gene

Genomics for TRIM10 Gene

Regulatory Elements for TRIM10 Gene

Enhancers for TRIM10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G029963 2 FANTOM5 Ensembl ENCODE dbSUPER 13.9 +197.2 197191 4.8 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 HLA-A HLA-K HLA-W HLA-H HLA-J HCG4P5 MICD HCG4 IFITM4P HLA-F
GH06G030129 1.3 Ensembl ENCODE 12.1 +32.5 32533 3.1 HDGF PKNOX1 MLX ARNT SIN3A ARID4B FEZF1 ZNF2 ZNF143 DEK TRIM40 TRIM31 TRIM31-AS1 TRIM10 TRIM15 HLA-A HCG18 ENSG00000252228 GC06M030273
GH06G030133 1.1 ENCODE 12 +27.8 27829 4.2 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF263 TRIM31 HLA-K HLA-A TRIM31-AS1 TRIM10 TRIM15 HCG17 LINC00243 TRIM40 RPL23AP1
GH06G031113 1.2 Ensembl ENCODE 5.3 -951.5 -951468 2.5 ATF1 PKNOX1 SIN3A FEZF1 GLIS2 FOS REST CREB3 SMARCA4 GLIS1 PSORS1C1 HCG22 MICB ENSG00000272501 POU5F1 HLA-C TRIM10 TCF19 CDSN
GH06G030879 1.4 ENCODE dbSUPER 3.9 -720.9 -720944 9.2 HDGF PKNOX1 FOXA2 WRNIP1 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 CBX5 VARS2 GNL1 HLA-C PSORS1C1 GTF2H4 PSORS1C3 SFTA2 HCG18 IER3 FLOT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM10 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM10 Gene

Chromosome:
6
Start:
30,151,939 bp from pter
End:
30,163,440 bp from pter
Size:
11,502 bases
Orientation:
Minus strand

Genomic View for TRIM10 Gene

Genes around TRIM10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TRIM10 Gene

  • Protein details for TRIM10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UDY6-TRI10_HUMAN
    Recommended name:
    Tripartite motif-containing protein 10
    Protein Accession:
    Q9UDY6
    Secondary Accessions:
    • A6NF84
    • Q5SRJ5
    • Q5SRK8
    • Q86Z08
    • Q96QB6
    • Q9C023
    • Q9C024

    Protein attributes for TRIM10 Gene

    Size:
    481 amino acids
    Molecular mass:
    55037 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIM10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM10 Gene

Post-translational modifications for TRIM10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM10 Gene

No data available for DME Specific Peptides for TRIM10 Gene

Domains & Families for TRIM10 Gene

Gene Families for TRIM10 Gene

Suggested Antigen Peptide Sequences for TRIM10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UDY6

UniProtKB/Swiss-Prot:

TRI10_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM10: view

Function for TRIM10 Gene

Molecular function for TRIM10 Gene

UniProtKB/Swiss-Prot Function:
Seems to play an important role in erythropoiesis.

Gene Ontology (GO) - Molecular Function for TRIM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM10: view
genes like me logo Genes that share phenotypes with TRIM10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM10 Gene

Localization for TRIM10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM10 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM10 gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for TRIM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with TRIM10: view

Pathways & Interactions for TRIM10 Gene

genes like me logo Genes that share pathways with TRIM10: view

Pathways by source for TRIM10 Gene

Gene Ontology (GO) - Biological Process for TRIM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0030218 erythrocyte differentiation IEA --
GO:0045087 innate immune response IEA --
GO:0046597 negative regulation of viral entry into host cell IEA --
genes like me logo Genes that share ontologies with TRIM10: view

No data available for SIGNOR curated interactions for TRIM10 Gene

Drugs & Compounds for TRIM10 Gene

No Compound Related Data Available

Transcripts for TRIM10 Gene

Unigene Clusters for TRIM10 Gene

Tripartite motif containing 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM10 Gene

No ASD Table

Relevant External Links for TRIM10 Gene

GeneLoc Exon Structure for
TRIM10
ECgene alternative splicing isoforms for
TRIM10

Expression for TRIM10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM10 Gene

This gene is overexpressed in Whole Blood (x15.7), Liver (x8.8), Colon - Transverse (x8.6), and Kidney - Cortex (x7.1).

Protein differential expression in normal tissues from HIPED for TRIM10 Gene

This gene is overexpressed in Fetal Liver (68.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM10 Gene



Protein tissue co-expression partners for TRIM10 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM10 Gene:

TRIM10

SOURCE GeneReport for Unigene cluster for TRIM10 Gene:

Hs.709483

Evidence on tissue expression from TISSUES for TRIM10 Gene

  • Blood(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with TRIM10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM10 Gene

Orthologs for TRIM10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM10 34 35
  • 98.82 (n)
cow
(Bos Taurus)
Mammalia TRIM10 34 35
  • 86.56 (n)
mouse
(Mus musculus)
Mammalia Trim10 34 16 35
  • 82.99 (n)
dog
(Canis familiaris)
Mammalia TRIM10 34 35
  • 82.7 (n)
rat
(Rattus norvegicus)
Mammalia Trim10 34
  • 82.01 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIM10 35
  • 76 (a)
OneToOne
Species where no ortholog for TRIM10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM10 Gene

ENSEMBL:
Gene Tree for TRIM10 (if available)
TreeFam:
Gene Tree for TRIM10 (if available)

Paralogs for TRIM10 Gene

(18) SIMAP similar genes for TRIM10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM10: view

Variants for TRIM10 Gene

Sequence variations from dbSNP and Humsavar for TRIM10 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000254148 -- 30,160,560(+) GCTCT(G/T)GGCAG reference, missense
rs1000408129 -- 30,157,002(+) CCTCT(A/G)GCCCA reference, stop-gained
rs1000806121 -- 30,164,911(+) CTCAT(C/T)GCTCA intron-variant, upstream-variant-2KB
rs1000862230 -- 30,156,823(+) AAGGC(A/C)CAGGA intron-variant
rs1001514069 -- 30,162,116(+) TAAAA(A/C)TACAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIM10 Gene

Variant ID Type Subtype PubMed ID
esv2731777 CNV deletion 23290073
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv601264 CNV loss 21841781

Variation tolerance for TRIM10 Gene

Residual Variation Intolerance Score: 87.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.12; 75.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM10 Gene

Disorders for TRIM10 Gene

Relevant External Links for TRIM10

Genetic Association Database (GAD)
TRIM10
Human Genome Epidemiology (HuGE) Navigator
TRIM10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM10

No disorders were found for TRIM10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM10 Gene

Publications for TRIM10 Gene

  1. Cloning, structural analysis, and mapping of the B30 and B7 multigenic families to the major histocompatibility complex (MHC) and other chromosomal regions. (PMID: 9271628) Henry J. … Pontarotti P. (Immunogenetics 1997) 2 3 4 64
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  3. Common genetic variation and the control of HIV-1 in humans. (PMID: 20041166) Fellay J. … Goldstein D.B. (PLoS Genet. 2009) 3 46 64
  4. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. (PMID: 16702430) Shiina T. … Bahram S. (Genetics 2006) 3 4 64
  5. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 3 4 64

Products for TRIM10 Gene

Sources for TRIM10 Gene

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