Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM10 Gene

protein-coding   GIFtS: 49
GCID: GC06M030119

Tripartite Motif Containing 10

(Previous name: tripartite motif-containing 10)
(Previous symbol: RNF9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tripartite Motif Containing 101 2     HERF12 5
RNF91 2 3 5     Hematopoietic RING Finger 12
RFB302 3 5     Tripartite Motif Protein 102
Tripartite Motif-Containing 101 2     Tripartite Motif-Containing Protein 102
RING Finger Protein 92 3     Zn-Finger Protein2
B30-RING Finger Protein2 3     

External Ids:    HGNC: 100721   Entrez Gene: 101072   Ensembl: ENSG000002046137   OMIM: 6057015   UniProtKB: Q9UDY63   

Export aliases for TRIM10 gene to outside databases

Previous GC identifers: GC06M030204 GC06M029890 GC06M030225 GC06M030227 GC06M029918


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRIM10 Gene:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes
to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of
erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TRIM10 Gene: 
TRIM10 (tripartite motif containing 10) is a protein-coding gene. Diseases associated with TRIM10 include hemochromatosis, and esophageal cancer. GO annotations related to this gene include molecular_function and zinc ion binding. An important paralog of this gene is TRIM7.

UniProtKB/Swiss-Prot: TRI10_HUMAN, Q9UDY6
Function: Seems to play an important role in erythropoiesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  
NT_167248.1  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM10 gene promoter:
         Max1   NF-1/L   MyoD   Nkx2-5   c-Ets-1   Arnt   MZF-1   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM10 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21.3

TRIM10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM10 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M030119:  view genomic region     (about GC identifiers)

Start:
30,119,722 bp from pter      End:
30,128,711 bp from pter
Size:
8,990 bases      Orientation:
minus strand

6/7 alternative locations (see all 7):
Chr6-,NT_167245 1,413,447-1,422,435      Chr6-,NT_167246 1,468,287-1,477,275      Chr6-,NT_167249 1,450,168-1,459,159     
Chr6-,NT_113891.2 1,631,859-1,640,846      Chr6-,NT_167248 1,412,670-1,421,658      Chr6-,NT_167244 1,359,957-1,368,945     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRI10_HUMAN, Q9UDY6 (See protein sequence)
Recommended Name: Tripartite motif-containing protein 10  
Size: 481 amino acids; 55037 Da
Subcellular location: Cytoplasm
Secondary accessions: A6NF84 Q5SRJ5 Q5SRK8 Q86Z08 Q96QB6 Q9C023 Q9C024
Alternative splicing: 2 isoforms:  Q9UDY6-1   Q9UDY6-2   (Ref.2 (AAG53496) sequence is in conflict in position: 379:C->G)

Explore the universe of human proteins at neXtProt for TRIM10: NX_Q9UDY6

Explore proteomics data for TRIM10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UDY6

  • TRIM10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRIM10 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_006769.2  NP_439893.2  

    ENSEMBL proteins: 
     ENSP00000397073   ENSP00000365894  

    Human Recombinant Protein Products for TRIM10: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TRIM10
    OriGene Protein Over-expression Lysate for TRIM10
    OriGene MassSpec for TRIM10 
    OriGene Custom Protein Services for TRIM10
    GenScript Custom Purified and Recombinant Proteins Services for TRIM10
    Novus Biologicals TRIM10 Proteins
    Novus Biologicals TRIM10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIM10 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ISS--

    TRIM10 for ontologies           About GeneDecksing



    TRIM10 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TRIM10
    GenScript Custom Superior Antibodies Services for TRIM10
    Novus Biologicals TRIM10 Antibodies
    Abcam antibodies for TRIM10
    Cloud-Clone Corp. Antibodies for TRIM10 
    ThermoFisher Antibodies for TRIM10
    LSBio Antibodies in human, mouse, rat for TRIM10 

    Assay Products for TRIM10: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRIM10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRIM10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRIM10 
    Cloud-Clone Corp. CLIAs for TRIM10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    5/10 InterPro protein domains (see all 10):
     IPR006574 PRY
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q9UDY6

    ProtoNet protein and cluster: Q9UDY6

    4 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: TRI10_HUMAN, Q9UDY6
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    TRIM10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI10_HUMAN, Q9UDY6
    Function: Seems to play an important role in erythropoiesis (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    TRIM10 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRIM10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRIM10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM10 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM10 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM10
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM10:
    hsa-miR-612 hsa-miR-1285 hsa-miR-103a-2* hsa-miR-877
    SwitchGear 3'UTR luciferase reporter plasmidTRIM10 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRIM10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRIM10
    Sirion Biotech Customized adenovirus for overexpression of TRIM10

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TRIM10 (see all 9)
    OriGene ORF clones in mouse, rat for TRIM10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM10 (NM_052828)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM10
    Sirion Biotech Customized lentivirus for stable overexpression of TRIM10 
                         Customized lentivirus expression plasmids for stable overexpression of TRIM10 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRIM10
    Search LifeMap BioReagents cell lines for TRIM10
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRIM10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TRIM10 (ENSP000003970734) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235025ENSP000003955984STRING: ENSP00000395598
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0030218erythrocyte differentiation IEA--

    TRIM10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM10 (TRI10)

    Search CenterWatch for drugs/clinical trials and news about TRIM10 / TRI10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRIM10 gene (2 alternative transcripts): 
    NM_006778.3  NM_052828.2  

    Unigene Cluster for TRIM10:

    Tripartite motif containing 10
    Hs.709483  [show with all ESTs]
    Unigene Representative Sequence: NM_006778
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449742(uc003npo.3) ENST00000376704(uc003npn.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM10
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM10:
    hsa-miR-612 hsa-miR-1285 hsa-miR-103a-2* hsa-miR-877
    SwitchGear 3'UTR luciferase reporter plasmidTRIM10 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRIM10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM10
    Clone
    Products:
         
    OriGene clones in human, mouse for TRIM10 (see all 9)
    OriGene ORF clones in mouse, rat for TRIM10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM10 (NM_052828)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM10
    Sirion Biotech Customized lentivirus for stable overexpression of TRIM10 
                         Customized lentivirus expression plasmids for stable overexpression of TRIM10 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIM10
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM10

    Additional mRNA sequence: 

    AF220122.1 AF220123.1 AL360163.1 AL360164.1 BC093926.1 BC113419.1 L19497.1 Y13935.1 

    6 DOTS entries:

    DT.409181  DT.100778123  DT.100646208  DT.408318  DT.100705171  DT.95253744 

    24/57 AceView cDNA sequences (see all 57):

    BX497949 BX494330 H59223 AA723071 AA004608 H58199 BX405576 BX106141 
    AA723050 AA733026 NM_006778 BX107289 BX328078 AI240570 AI566746 AF220123 
    BX494456 AA706979 NM_052828 AI242180 AI248753 BX494288 BX371998 AL360164 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTCCTGGCG
    TRIM10 Expression
    About this image


    See TRIM10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM10

    SOURCE GeneReport for Unigene cluster: Hs.709483
        SABiosciences Expression via Pathway-Focused PCR Arrays including TRIM10: 
              Polycomb & Trithorax Target Genes in human mouse rat
              Ubiquitin Ligases in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Hematopoiesis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIM10
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM10
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM10 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim101 , 5 tripartite motif-containing 101, 5 82.99(n)1
    84.37(a)1
      17 (19.16 cM)5
    198241  NM_011280.21  NP_035410.21 
     368695745 
    chicken
    (Gallus gallus)
    Aves TRIM7.26
    TRIM27.16
    tripartite motif-containing 27
    33(a)
    29(a)
    many ↔ many
    many ↔ many
    16(209966-214262)
    16(150525-169149)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 31)
    Uncharacterized protein
    (see all 31)
    36(a)
    36(a)
    (see all 31)
    possible ortholog
    possible ortholog
    (see all 31)
    2(195919842-195929549)
    2(195256558-195278379)


    ENSEMBL Gene Tree for TRIM10 (if available)
    TreeFam Gene Tree for TRIM10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM10 gene
    TRIM72  TRIM42  TRIM262  TRIM392  TRIM342  TRIM272  TRIM582  TRIM682  
    TRIM152  TRIM602  TRIM222  TRIM172  TRIM52  TRIM62  TRIM6-TRIM342  TRIM212  
    TRIM382  TRIM112  TRIM39-RPP212  
    18 SIMAP similar genes for TRIM10 using alignment to 1 protein entry:     TRI10_HUMAN:
    TRIM15    ZNFB7    DKFZp686F23130    TRIM26    TRIM39    TRIM39R
    TRIM68    TRIM7    TRIM27    TRIM38    TRIM6    TRIM21
    TRIM60    TRIM69    TRIM75    TRIM11    TRIM41    TRIM58

    TRIM10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/357 SNPs in TRIM10 are shown (see all 357)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs69054551,2
    C--30119263(+) GGTGAC/TCCCAC 2 -- int12Minor allele frequency- T:0.09WA 120
    rs92615261,2
    C,F,A,H--30119275(+) AACTCG/ACTCAC 2 -- int110Minor allele frequency- A:0.23NS EA NA CSA WA 781
    rs1181665441,2
    C,F--30119280(+) GCTCAC/TGCCTG 2 -- int11Minor allele frequency- T:0.11EA 120
    rs1932940311,2
    --30119281(+) CTCACA/GCCTGA 2 -- int10--------
    rs92615271,2
    C,F,A,H--30119392(+) TCTCAG/ATTCTT 2 -- int110Minor allele frequency- A:0.23NS EA NA CSA WA 784
    rs92615281,2
    C,F,A,H--30119429(+) AAGCTT/GTGAAA 2 -- int113Minor allele frequency- G:0.23NS EA NA CSA WA 922
    rs1430224901,2
    C--30119433(+) TTTGAA/TAAATG 2 -- int10--------
    rs1486674201,2
    --30119485(+) AGAGTC/TGGAAA 2 -- int10--------
    rs1855463881,2
    --30119486(+) GAGTCA/GGAAAG 2 -- int10--------
    rs1902574041,2
    --30119531(+) ACTTCC/TTGGGG 2 -- int10--------

    HapMap Linkage Disequilibrium report for TRIM10 (30119722 - 30128711 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TRIM10:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2731777CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM10
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605701    OMIM disorders: --

    5 diseases for TRIM10:    About MalaCards
    hemochromatosis    esophageal cancer    systemic lupus erythematosus    esophagitis
    lupus erythematosus


    TRIM10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRIM10
    Human Genome Epidemiology (HuGE) Navigator: TRIM10 (2 documents)

    Export disorders for TRIM10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM10 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with TRIM10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, structural analysis, and mapping of the B30 and B7 multigenic families to the major histocompatibility complex (MHC) and other chromosomal regions. (PubMed id 9271628)1, 2, 3 Henry J.... Pontarotti P. (1997)
    2. Common genetic variation and the control of HIV-1 in humans. (PubMed id 20041166)1, 4 Fellay J....Goldstein D.B. (2009)
    3. High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (2009)
    4. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. (PubMed id 16702430)1, 2 Shiina T.... Bahram S. (2006)
    5. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2 Reymond A.... Ballabio A. (2001)
    6. HERF1, a novel hematopoiesis-specific RING finger protein, is required for terminal differentiation of erythroid cells. (PubMed id 10207104)1, 3 Harada H....Downing J.R. (1999)
    7. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    8. Functional interactions between ubiquitin E2 enzymes a nd TRIM proteins. (PubMed id 21143188)1 Napolitano L.M....Meroni G. (2011)
    9. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PubMed id 19010793)4 Baranzini S.E....Oksenberg J.R. (2008)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10107 HGNC: 10072 AceView: TRIM10 Ensembl:ENSG00000204613 euGenes: HUgn10107
    ECgene: TRIM10 H-InvDB: TRIM10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRIM10 gene:
    Search GeneIP for patents involving TRIM10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TRIM10  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TRIM10  
     OriGene MassSpec something-or-other for TRIM10   OriGene clones in human, mouse for TRIM10  
     OriGene qSTAR qPCR primer pairs in human, mouse for TRIM10   OriGene Purified Protein for TRIM10  
     OriGene ORF clones in mouse, rat for TRIM10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRIM10   OriGene Custom Protein Services for TRIM10  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIM10
     QIAGEN SeqTarget long-range PCR primers for resequencing TRIM10
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM10
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM10
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM10
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM10
     GenScript Custom Purified and Recombinant Proteins Services for TRIM10 GenScript cDNA clones with any tag delivered in your preferred vector for TRIM10
     GenScript Custom Assay Services for TRIM10 GenScript Custom Superior Antibodies Services for TRIM10
     GenScript Custom overexpressing Cell Line Services for TRIM10 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TRIM10 promoter
     Search Chromatin IP Primers for TRIM10
     RT2 qPCR Primer Assay in human, mouse, rat TRIM10
     GNC Network for TRIM10
     SABiosciences PCR Arrays including human, mouse, rat TRIM10
     Search Tocris compounds for TRIM10 (TRI10)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TRIM10 antibodies
     TRIM10 proteins
     TRIM10 lysates
     Antibodies for TRIM10
     See all of Abcam's Antibodies, Kits and Proteins for TRIM10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TRIM10
     Antibodies for TRIM10
     ELISAs for TRIM10
     CLIAs for TRIM10
     Search LifeMap BioReagents cell lines for TRIM10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM10
     SwitchGear 3'UTR luciferase reporter plasmids for TRIM10
     SwitchGear Promoter luciferase reporter plasmids for TRIM10
     ThermoFisher Antibodies for TRIM10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM10
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TRIM10
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRIM10
    Customized:
     lentivirus for stable overexpression of TRIM10
     lentivirus expression plasmids for stable overexpression of TRIM10
     adenovirus for overexpression of TRIM10
     LSBio Antibodies in human, mouse, rat for TRIM10
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TRIM10 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4