TRIL Gene
protein-coding GIFtS : 43
GCID: GC07 M028992
TLR4 interactor with leucine-rich repeats
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Aliasesfor TRIL gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases TLR4 Interactor With Leucine-Rich Repeats 1 2 KIAA06441 3 5 TLR4 Interactor With Leucine Rich Repeats2 Leucine-Rich Repeat-Containing Protein KIAA06443
Export aliases for TRIL gene to outside databases Previous GC identifer: GC07M028960
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Summariesfor TRIL gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for TRIL : TRIL is a component of the TLR4 (MIM 603030) complex and is induced in a number of cell types by lipopolysaccharide (LPS) (Carpenter et al., 2009 (PubMed 19710467)).(supplied by OMIM, Apr 2010) UniProtKB/Swiss-Prot: TRIL_HUMAN, Q7L0X0 Function : Component of the TLR4 signaling complex. Mediate the innate immune response to bacterial lipopolysaccharide(LPS) leading to cytokine secretion Gene Wiki entry for TRIL (KIAA0644)
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Genomic Viewsfor TRIL gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for TRIL Other transcription factors Search SABiosciences Chromatin IP Primers for TRIL Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIL
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7p14.3 Ensembl cytogenetic band: 7p14.3 HGNC cytogenetic band: 7p14.3 TRIL Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07M028992: view genomic region
(about GC identifiers )
Start:
28,992,974 bp from pter
End:
28,998,029 bp from pter
Size:
5,056 bases
Orientation:
minus strand
1 alternative location : Chr 7-,CRA_TCAG 29,043,206-29,048,260
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Proteinsfor TRIL gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TRIL_HUMAN, Q7L0X0 (See
protein sequence )Recommended Name: TLR4 interactor with leucine rich repeats precursor Size : 811 amino acids; 88723 Da
Subunit : Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 andTLR4. Interacts with TLR4; this interaction is greatly enhanced by LPS stimulation. Interacts with LPS
Subcellular location : Membrane; Single-pass type I membrane protein (Potential)
Sequence caution : Sequence=BAA31619.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=EAL24209.1; Type=Erroneous gene model prediction;
Secondary accessions : A4D1A6 O75139Explore the universe of human proteins at neXtProt for TRIL: NX_Q7L0X0 Post-translational modifications:
N-glycolysaled1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q7L0X0 TRIL Protein expression data from MOPED and PaxDb : --REFSEQ proteins: NP_055632.2 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0046696 lipopolysaccharide receptor complex
IDA 19710467
TRIL for ontologies About GeneDecksing TRIL Antibody Products: Assay Products for TRIL:
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Protein
Domains / Familiesfor TRIL gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TRIL for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q7L0X0 ProtoNet protein and cluster: Q7L0X0
3 Blocks protein families : IPB000372 Cysteine-rich flanking region IPB000483 Cysteine-rich flanking region IPB001611 Leucine-rich repeat signature UniProtKB/Swiss-Prot: TRIL_HUMAN, Q7L0X0 Similarity : Contains 12 LRR (leucine-rich) repeatsSimilarity : Contains 1 LRRCT domainSimilarity : Contains 1 LRRNT domain
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Functionfor TRIL gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: TRIL_HUMAN, Q7L0X0 Function : Component of the TLR4 signaling complex. Mediate the innate immune response to bacterial lipopolysaccharide(LPS) leading to cytokine secretion Induction : By bacterial lipopolysaccharides (LPS)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TRIL (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TRILOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TRIL (NM_014817 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIL Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TRIL
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIL
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
TRIL for ontologies About GeneDecksing
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Pathways & Interactionsfor TRIL gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIL Gene Ontology (GO): 4 biological process terms (GO ID links to tree view) : About this table
TRIL for ontologies About GeneDecksing
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Drugs & Compoundsfor TRIL gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TRIL Search CenterWatch for drugs/clinical trials and news about TRIL
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Transcriptsfor TRIL gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TRIL gene: NM_014817.3 Unigene Cluster for TRIL:
TLR4 interactor with leucine-rich repeats Hs.744120 [show with all ESTs ] Unigene Representative Sequence: NM_014817 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000322982 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TRIL (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TRILOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TRIL (NM_014817 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIL Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TRIL
Additional cDNA sequence: AB014544.1 AK293803.1 BC036337.1
5 DOTS entries : DT.313342 DT.100023553
DT.121109339 DT.102822862 DT.95268153 24/81 AceView cDNA sequences (see all 81 ):
BQ719057 AA258720 AB014544 AW075623 BX094991 BM993296 AV702233 AL119053 AI880277 BF929303 BM674518 CB156767 AI569957 BU681837 AI569952 CA438231 CF541271 AI271913 BM701465 AA962153 BG696341 BM990678 AA678883 BE090209 GeneLoc Exon Structure
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Expression for TRIL gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TRIL expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AGAGCAGTAG
About this image TRIL expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Genevestigator expression for TRIL SOURCE GeneReport for Unigene cluster: Hs.744120 UniProtKB/Swiss-Prot: TRIL_HUMAN, Q7L0X0 Tissue specificity : Highly expressed in the brain, ovary, small intestine and spleen SABiosciences Custom PCR Arrays for TRIL Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TRILBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TRIL QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TRIL QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TRIL In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIL
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Orthologsfor TRIL gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for TRIL gene from 3/7 species (see all 7 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
Tril1 , 5
TLR4 interactor with leucine-rich repeats1, 5
85.17(n) 1 88.72(a) 1
 
6 (26.07 cM) 5 66873 1 NM_025817.4 1 NP_080093.1 1 53815466 5
chicken (Gallus gallus)
Aves
TRIL1
TLR4 interactor with leucine-rich repeats
69.98(n) 66.44(a)
 
428436 XM_425996.3 XP_425996.3
African clawed frog (Xenopus laevis)
Amphibia
Xl.162632
Xenopus laevis transcribed sequence with weak similarity to protein refNP_055632.1 (H.sapiens) KIAA0644 gene product [Homo sapiens] less
72.5(n)
 
BJ042506.1
ENSEMBL Gene Tree for TRIL (if available)TreeFam Gene Tree for TRIL (if available)
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Paralogsfor TRIL gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor TRIL gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 7 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TRIL (28992974 - 28998029 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TRIL: -- Human Gene Mutation Database (HGMD) : TRIL SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor TRIL gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TRIL for disorders About MalaCards
TRIL for disorders About GeneDecksing
OMIM gene information: 613356
OMIM disorders : --Human Genome Epidemiology (HuGE) Navigator: TRIL (0 documents) Export disorders for TRIL gene to outside databases
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Publicationsfor TRIL gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TRIL gene integrated from 9 sources : (articles sorted by number of sources associating them with TRIL) Utopia : connect your pdf to the dynamic world of online information
TRIL, a functional component of the TLR4 signaling co mplex, highly expressed in brain. (PubMed id 19710467) 1 , 2 , 3 Carpenter S....O'Neill L.A. (2009) Human chromosome 7: DNA sequence and biology. (PubMed id 12690205) 1 , 2 Scherer S.W.... Tsui L.-C. (2003) Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811) 1 , 2 Ishikawa K.... Ohara O. (1998) Toll-like receptor 3 (TLR3) signaling requires TLR4 I nteractor with leucine-rich REPeats (TRIL). (PubMed id 21911501) 1 Carpenter S....O'Neill L.A. (2011) Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535) 1 Wheeler H.E....Kim S.K. (2009) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) The DNA sequence of human chromosome 7. (PubMed id 12853948) 2 Hillier L.W.... Wilson R.K. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. (PubMed id 9776767) 1 Bussow K....Walter G. (1998)
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External Searches for TRIL gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TRIL gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TRIL gene
(According to HUGE )
About This Section
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Specialized Databases showing TRIL gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for TRIL gene: Search GeneIP for patents involving TRIL GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TRIL gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TRIL OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TRIL Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits Browse OriGene siRNAs OriGene 3'-UTR Clone for TRIL OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TRIL OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TRIL Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TRIL OriGene Custom Protein Services for TRIL OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIL Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIL QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIL QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TRIL QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TRIL QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TRIL
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TRIL Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIL
ThermoFisher Antibodies for TRIL
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TRIL
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