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Aliases for TRIL Gene

Aliases for TRIL Gene

  • TLR4 Interactor With Leucine-Rich Repeats 2 3 5
  • Leucine-Rich Repeat-Containing Protein KIAA0644 4
  • KIAA0644 4

External Ids for TRIL Gene

Previous GeneCards Identifiers for TRIL Gene

  • GC07M028960
  • GC07M028992

Summaries for TRIL Gene

Entrez Gene Summary for TRIL Gene

  • TRIL is a component of the TLR4 (MIM 603030) complex and is induced in a number of cell types by lipopolysaccharide (LPS) (Carpenter et al., 2009 [PubMed 19710467]).[supplied by OMIM, Apr 2010]

GeneCards Summary for TRIL Gene

TRIL (TLR4 Interactor With Leucine-Rich Repeats) is a Protein Coding gene. GO annotations related to this gene include lipopolysaccharide binding. An important paralog of this gene is LRRTM2.

UniProtKB/Swiss-Prot for TRIL Gene

  • Component of the TLR4 signaling complex. Mediate the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion.

Gene Wiki entry for TRIL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIL Gene

Genomics for TRIL Gene

Regulatory Elements for TRIL Gene

Enhancers for TRIL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIL on UCSC Golden Path with GeneCards custom track

Promoters for TRIL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIL on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIL Gene

28,953,358 bp from pter
28,958,413 bp from pter
5,056 bases
Minus strand

Genomic View for TRIL Gene

Genes around TRIL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIL Gene

Proteins for TRIL Gene

  • Protein details for TRIL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TLR4 interactor with leucine rich repeats
    Protein Accession:
    Secondary Accessions:
    • A4D1A6
    • O75139

    Protein attributes for TRIL Gene

    811 amino acids
    Molecular mass:
    88723 Da
    Quaternary structure:
    • Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4. Interacts with TLR4; this interaction is greatly enhanced by LPS stimulation. Interacts with LPS.
    • Sequence=BAA31619.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAL24209.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for TRIL Gene

Proteomics data for TRIL Gene at MOPED

Post-translational modifications for TRIL Gene

Other Protein References for TRIL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIL Gene

Domains & Families for TRIL Gene

Suggested Antigen Peptide Sequences for TRIL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 LRRCT domain.
  • Contains 12 LRR (leucine-rich) repeats.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
  • Contains 12 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with TRIL: view

No data available for Gene Families for TRIL Gene

Function for TRIL Gene

Molecular function for TRIL Gene

UniProtKB/Swiss-Prot Function:
Component of the TLR4 signaling complex. Mediate the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion.
UniProtKB/Swiss-Prot Induction:
By bacterial lipopolysaccharides (LPS).

Gene Ontology (GO) - Molecular Function for TRIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 19710467
genes like me logo Genes that share ontologies with TRIL: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIL Gene

Localization for TRIL Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIL Gene

Membrane; Single-pass type I membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRIL Gene

Pathways & Interactions for TRIL Gene

SuperPathways for TRIL Gene

No Data Available

Interacting Proteins for TRIL Gene

Gene Ontology (GO) - Biological Process for TRIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with TRIL: view

No data available for Pathways by source and SIGNOR curated interactions for TRIL Gene

Drugs & Compounds for TRIL Gene

No Compound Related Data Available

Transcripts for TRIL Gene

mRNA/cDNA for TRIL Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(81) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIL Gene

TLR4 interactor with leucine-rich repeats:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIL Gene

No ASD Table

Relevant External Links for TRIL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIL Gene

mRNA expression in normal human tissues for TRIL Gene

Protein differential expression in normal tissues from HIPED for TRIL Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRIL Gene

SOURCE GeneReport for Unigene cluster for TRIL Gene Hs.744120

mRNA Expression by UniProt/SwissProt for TRIL Gene

Tissue specificity: Highly expressed in the brain, ovary, small intestine and spleen.
genes like me logo Genes that share expression patterns with TRIL: view

Protein tissue co-expression partners for TRIL Gene

Primer Products

No data available for mRNA differential expression in normal tissues for TRIL Gene

Orthologs for TRIL Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIL 35
  • 89.08 (n)
  • 90.36 (a)
(Canis familiaris)
Mammalia TRIL 35
  • 90.01 (n)
  • 90.01 (a)
(Mus musculus)
Mammalia Tril 35
  • 85.21 (n)
  • 88.6 (a)
Tril 16
(Pan troglodytes)
Mammalia TRIL 35
  • 99.47 (n)
  • 99.14 (a)
(Rattus norvegicus)
Mammalia Tril 35
  • 85.46 (n)
  • 88.75 (a)
(Gallus gallus)
Aves TRIL 35
  • 70.14 (n)
  • 67.48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tril 35
  • 55.58 (n)
  • 53.17 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16263 35
Species with no ortholog for TRIL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIL Gene

Gene Tree for TRIL (if available)
Gene Tree for TRIL (if available)

Paralogs for TRIL Gene

(1) SIMAP similar genes for TRIL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIL: view

Variants for TRIL Gene

Sequence variations from dbSNP and Humsavar for TRIL Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs740250 - 28,957,328(+) GCAGG(C/T)TGTTG reference, missense
rs3735561 - 28,957,008(-) TCGCC(A/G)CCAGC reference, missense
rs3735562 - 28,956,941(-) GCGAG(A/G)CCTGA reference, missense
VAR_075695 -
rs1006521 -- 28,956,604(+) CTTAG(A/G)GCGCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TRIL Gene

Variant ID Type Subtype PubMed ID
nsv524487 CNV Loss 19592680

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for TRIL Gene

Disorders for TRIL Gene

Relevant External Links for TRIL

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRIL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIL Gene

Publications for TRIL Gene

  1. TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain. (PMID: 19710467) Carpenter S. … O'Neill L.A. (J. Immunol. 2009) 2 3 4 67
  2. Toll-like receptor 3 (TLR3) signaling requires TLR4 Interactor with leucine-rich REPeats (TRIL). (PMID: 21911501) Carpenter S. … O'Neill L.A. (J. Biol. Chem. 2011) 3
  3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler H.E. … Kim S.K. (PLoS Genet. 2009) 3
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TRIL Gene

Sources for TRIL Gene