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Aliases for TRIB3 Gene

Aliases for TRIB3 Gene

  • Tribbles Pseudokinase 3 2 3
  • Neuronal Cell Death-Inducible Putative Kinase 3 4
  • P65-Interacting Inhibitor Of NF-Kappa-B 3 4
  • C20orf97 3 4
  • SKIP3 3 4
  • TRB-3 3 4
  • NIPK 3 4
  • SINK 3 4
  • TRB3 3 4
  • Neuronal Cell Death Inducible Putative Kinase 3
  • P65-Interacting Inhibitor Of NF-KappaB 3
  • Chromosome 20 Open Reading Frame 97 2
  • Tribbles Homolog 3 (Drosophila) 2
  • Tribbles Homolog 3 3

External Ids for TRIB3 Gene

Previous HGNC Symbols for TRIB3 Gene

  • C20orf97

Previous GeneCards Identifiers for TRIB3 Gene

  • GC20P000357
  • GC20P000309

Summaries for TRIB3 Gene

Entrez Gene Summary for TRIB3 Gene

  • The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for TRIB3 Gene

TRIB3 (Tribbles Pseudokinase 3) is a Protein Coding gene. Diseases associated with TRIB3 include anoxia. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include protein kinase binding and ubiquitin protein ligase binding. An important paralog of this gene is NUAK1.

UniProtKB/Swiss-Prot for TRIB3 Gene

  • Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the Thr-308 phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.

Gene Wiki entry for TRIB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIB3 Gene

Genomics for TRIB3 Gene

Regulatory Elements for TRIB3 Gene

Genomic Location for TRIB3 Gene

Start:
362,835 bp from pter
End:
397,559 bp from pter
Size:
34,725 bases
Orientation:
Plus strand

Genomic View for TRIB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIB3 Gene

Proteins for TRIB3 Gene

  • Protein details for TRIB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RU7-TRIB3_HUMAN
    Recommended name:
    Tribbles homolog 3
    Protein Accession:
    Q96RU7
    Secondary Accessions:
    • Q53GU4
    • Q53ZW7
    • Q6I9Y9
    • Q8TAI6
    • Q9H5M8
    • Q9NUD2

    Protein attributes for TRIB3 Gene

    Size:
    358 amino acids
    Molecular mass:
    39578 Da
    Quaternary structure:
    • Interacts with AKT1, AKT2, ATF4, MAP2K1 and MAP2K7. Interacts with DDIT3/CHOP and inhibits its interaction with EP300/P300. Interacts (via N-terminus) with APOBEC3A. Interacts with APOBEC3C.

neXtProt entry for TRIB3 Gene

Proteomics data for TRIB3 Gene at MOPED

Post-translational modifications for TRIB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIB3 Gene

No data available for DME Specific Peptides for TRIB3 Gene

Domains for TRIB3 Gene

Gene Families for TRIB3 Gene

Protein Domains for TRIB3 Gene

Suggested Antigen Peptide Sequences for TRIB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RU7

UniProtKB/Swiss-Prot:

TRIB3_HUMAN :
  • Q96RU7
Domain:
  • The protein kinase domain is predicted to be catalytically inactive
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
genes like me logo Genes that share domains with TRIB3: view

Function for TRIB3 Gene

Molecular function for TRIB3 Gene

UniProtKB/Swiss-Prot Function: Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the Thr-308 phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.
UniProtKB/Swiss-Prot Induction: By hypoxia, TNF, and by nutrient starvation. Expression is PI 3-kinase and/or NF-kappa-B-dependent. Induced by ER stress via ATF4-DDIT3/CHOP pathway and can downregulate its own induction by repression of ATF4-DDIT3/CHOP functions.

Gene Ontology (GO) - Molecular Function for TRIB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity ISS --
GO:0004672 protein kinase activity --
GO:0004860 protein kinase inhibitor activity IEA --
GO:0005515 protein binding IPI 12743605
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TRIB3: view
genes like me logo Genes that share phenotypes with TRIB3: view

Animal Models for TRIB3 Gene

MGI Knock Outs for TRIB3:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TRIB3 Gene

Localization for TRIB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIB3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIB3 Gene COMPARTMENTS Subcellular localization image for TRIB3 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 4
mitochondrion 3
endoplasmic reticulum 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for TRIB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with TRIB3: view

Pathways for TRIB3 Gene

SuperPathways for TRIB3 Gene

Superpath Contained pathways
1 PI-3K cascade
2 Signaling by FGFR
3 Insulin receptor signalling cascade
4 CD28 co-stimulation
5 Fatty acid, triacylglycerol, and ketone body metabolism
genes like me logo Genes that share pathways with TRIB3: view

Pathways by source for TRIB3 Gene

1 Sino Biological pathway for TRIB3 Gene
2 BioSystems pathways for TRIB3 Gene

Gene Ontology (GO) - Biological Process for TRIB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 15775988
GO:0006351 transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation IEA --
GO:0006469 negative regulation of protein kinase activity IDA 12791994
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TRIB3: view

Compounds for TRIB3 Gene

(1) Novoseek inferred chemical compound relationships for TRIB3 Gene

Compound -log(P) Hits PubMed IDs
glucose 7.53 12
genes like me logo Genes that share compounds with TRIB3: view

Transcripts for TRIB3 Gene

Unigene Clusters for TRIB3 Gene

Tribbles homolog 3 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIB3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: -
SP5: - -
SP6:

Relevant External Links for TRIB3 Gene

GeneLoc Exon Structure for
TRIB3
ECgene alternative splicing isoforms for
TRIB3

Expression for TRIB3 Gene

mRNA expression in normal human tissues for TRIB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIB3 Gene

This gene is overexpressed in Liver (9.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TRIB3 Gene

SOURCE GeneReport for Unigene cluster for TRIB3 Gene Hs.516826

mRNA Expression by UniProt/SwissProt for TRIB3 Gene

Q96RU7-TRIB3_HUMAN
Tissue specificity: Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney.
genes like me logo Genes that share expressions with TRIB3: view

Orthologs for TRIB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIB3 35
  • 96.37 (n)
  • 95.24 (a)
TRIB3 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIB3 35
  • 81.7 (n)
  • 82.79 (a)
TRIB3 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIB3 35
  • 84.97 (n)
  • 83.38 (a)
TRIB3 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trib3 35
  • 76.84 (n)
  • 74.58 (a)
Trib3 16
Trib3 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIB3 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trib3 35
  • 75.17 (n)
  • 74.5 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 21 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia TRIB3 36
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii trib3 35
  • 57.91 (n)
  • 56.93 (a)
trib3 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta trbl 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nipi-3 36
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8356 36
  • 32 (a)
OneToMany
Species with no ortholog for TRIB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRIB3 Gene

ENSEMBL:
Gene Tree for TRIB3 (if available)
TreeFam:
Gene Tree for TRIB3 (if available)

Paralogs for TRIB3 Gene

Paralogs for TRIB3 Gene

Selected SIMAP similar genes for TRIB3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIB3: view

Variants for TRIB3 Gene

Sequence variations from dbSNP and Humsavar for TRIB3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs910070 -- 381,137(+) CCGGC(G/T)GCGCC upstream-variant-2KB, utr-variant-5-prime
rs1063081 -- 397,457(+) CTCTT(C/T)TGGGG utr-variant-3-prime
rs1980583 -- 386,036(-) AAAAA(A/T)TTTTT intron-variant
rs2018591 -- 382,362(+) TGGCC(C/G)GGGCC intron-variant
rs2092474 -- 380,548(+) GGGCG(C/T)GGTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIB3 Gene

Variant ID Type Subtype PubMed ID
nsv912559 CNV Loss 21882294
nsv458839 CNV Loss 19166990
nsv470534 CNV Loss 18288195
nsv510777 CNV Loss 20534489
dgv773e199 CNV Deletion 23128226
nsv458841 CNV Loss 19166990
nsv458842 CNV Loss 19166990
dgv4508n71 CNV Gain 21882294
nsv912562 CNV Loss 21882294
esv2657243 CNV Deletion 23128226
nsv519415 CNV Loss 19592680
esv2057444 CNV Deletion 18987734
nsv912563 CNV Loss 21882294
dgv4509n71 CNV Gain 21882294

Relevant External Links for TRIB3 Gene

HapMap Linkage Disequilibrium report
TRIB3
Human Gene Mutation Database (HGMD)
TRIB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIB3 Gene

Disorders for TRIB3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TRIB3 Gene including...

Search for TRIB3 Gene in MalaCards »

(2) Novoseek inferred disease relationships for TRIB3 Gene

Disease -log(P) Hits PubMed IDs
insulin resistance 40.5 10
tumors 0 5

Relevant External Links for TRIB3

Genetic Association Database (GAD)
TRIB3
Human Genome Epidemiology (HuGE) Navigator
TRIB3
genes like me logo Genes that share disorders with TRIB3: view

No data available for UniProtKB/Swiss-Prot for TRIB3 Gene

Publications for TRIB3 Gene

  1. SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription. (PMID: 12736262) Wu M. … Shu H.B. (J. Biol. Chem. 2003) 3 4 23
  2. SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia. (PMID: 12743605) Bowers A.J. … Boylan J.F. (Oncogene 2003) 3 4 23
  3. TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. (PMID: 15775988) Ohoka N. … Hayashi H. (EMBO J. 2005) 3 4 23
  4. Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions. (PMID: 15781252) Ord D. … Ord T. (Biochem. Biophys. Res. Commun. 2005) 3 4 23
  5. The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy. (PMID: 16123373) Prudente S. … Trischitta V. (Diabetes 2005) 3 23 48

Products for TRIB3 Gene

  • Addgene plasmids for TRIB3

Sources for TRIB3 Gene

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