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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIB3 Gene

protein-coding   GIFtS: 63
GCID: GC20P000361

Tribbles Pseudokinase 3

(Previous names: chromosome 20 open reading frame 97, tribbles homolog 3...)
(Previous symbol: C20orf97)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tribbles Pseudokinase 31     TRB-32 3
C20orf971 2 3     TRB32 3
Tribbles Homolog 3 (Drosophila)1 2     P65-Interacting Inhibitor Of NF-Kappa-B2 3
Neuronal Cell Death-Inducible Putative Kinase2 3     Chromosome 20 Open Reading Frame 971
NIPK2 3     Neuronal Cell Death Inducible Putative Kinase2
SINK2 3     P65-Interacting Inhibitor Of NF-KappaB2
SKIP32 3     Tribbles Homolog 32

External Ids:    HGNC: 162281   Entrez Gene: 577612   Ensembl: ENSG000001012557   OMIM: 6078985   UniProtKB: Q96RU73   

Export aliases for TRIB3 gene to outside databases

Previous GC identifers: GC20P000357 GC20P000309


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRIB3 Gene:
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor
NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and
TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine
kinase AKT1. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRIB3 Gene: 
TRIB3 (tribbles pseudokinase 3) is a protein-coding gene. Diseases associated with TRIB3 include anoxia, and neuronitis, and among its related super-pathways are Signaling by FGFR and Constitutive PI3K/AKT Signaling in Cancer. GO annotations related to this gene include protein kinase binding and ubiquitin protein ligase binding. An important paralog of this gene is BRSK1.

UniProtKB/Swiss-Prot: TRIB3_HUMAN, Q96RU7
Function: Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind
directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional
activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and
thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP
kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does
not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in
DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA

Gene Wiki entry for TRIB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011387.8  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIB3 gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13-p12.2   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13-p12.2

TRIB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIB3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P000361:  view genomic region     (about GC identifiers)

Start:
361,261 bp from pter      End:
378,203 bp from pter
Size:
16,943 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRIB3_HUMAN, Q96RU7 (See protein sequence)
Recommended Name: Tribbles homolog 3  
Size: 358 amino acids; 39578 Da
Subunit: Interacts with AKT1, AKT2, ATF4, MAP2K1 and MAP2K7. Interacts with DDIT3/CHOP and inhibits its
interaction with EP300/P300. Interacts (via N-terminus) with APOBEC3A. Interacts with APOBEC3C
Subcellular location: Nucleus
Caution: The role of this protein in Akt activation has been demonstrated by Du et al (PubMed:12791994) for the
mouse ortholog but Iynedjian (PubMed:15469416) has not been able to reproduce the result in rat hepatocytes
Secondary accessions: Q53GU4 Q53ZW7 Q6I9Y9 Q8TAI6 Q9H5M8 Q9NUD2

Explore the universe of human proteins at neXtProt for TRIB3: NX_Q96RU7

Explore proteomics data for TRIB3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96RU7

  • TRIB3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRIB3 Protein Expression
    REFSEQ proteins: NP_066981.2  
    ENSEMBL proteins: 
     ENSP00000217233   ENSP00000391873   ENSP00000415416  
    Reactome Protein details: Q96RU7
    Human Recombinant Protein Products for TRIB3: 
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    OriGene Protein Over-expression Lysate for TRIB3
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    Novus Biologicals TRIB3 Proteins
    Novus Biologicals TRIB3 Lysates
    Sino Biological Recombinant Protein for TRIB3
    Sino Biological Cell Lysate for TRIB3 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIB3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    TRIB3 for ontologies           About GeneDecksing



    TRIB3 Antibody Products: 
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    Abcam antibodies for TRIB3
    Cloud-Clone Corp. Antibodies for TRIB3 
    ThermoFisher Antibody for TRIB3
    LSBio Antibodies in human, mouse, rat for TRIB3 

    Assay Products for TRIB3: 
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    Cloud-Clone Corp. ELISAs for TRIB3 
    Cloud-Clone Corp. CLIAs for TRIB3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: tribbles homolog 3 (Drosophila) 
    Trbl family

    4 InterPro protein domains:
     IPR024104 Tribbles/Ser_Thr_kinase_40
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR024106 Tribbles_TRB3

    Graphical View of Domain Structure for InterPro Entry Q96RU7

    ProtoNet protein and cluster: Q96RU7

    UniProtKB/Swiss-Prot: TRIB3_HUMAN, Q96RU7
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily
    Similarity: Contains 1 protein kinase domain


    TRIB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRIB3_HUMAN, Q96RU7
    Function: Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind
    directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional
    activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and
    thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP
    kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does
    not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in
    DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA
    Induction: By hypoxia, TNF, and by nutrient starvation. Expression is PI 3-kinase and/or NF-kappa-B-dependent.
    Induced by ER stress via ATF4-DDIT3/CHOP pathway and can downregulate its own induction by repression of
    ATF4-DDIT3/CHOP functions

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity ISS--
    GO:0004672protein kinase activity ----
    GO:0004860protein kinase inhibitor activity IEA--
    GO:0005515protein binding IPI12743605
    GO:0005524ATP binding IEA--
         
    TRIB3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRIB3:
     Decreased substrate adherent c  Upregulation of NF-kappaB path 

         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Trib3):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  immune system  limbs/digits/tail 
     normal 

    TRIB3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TRIB3: Trib3tm1Tord Trib3tm1Mws

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRIB3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRIB3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIB3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIB3 

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRIB3:
    hsa-mir-24 (MIRT003354)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIB3
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIB3 (see all 11):
    hsa-miR-4254 hsa-miR-1271 hsa-miR-146a* hsa-miR-124 hsa-miR-182 hsa-miR-3116 hsa-miR-1207-3p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidTRIB3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRIB3
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of TRIB3

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TRIB3 (see all 7)
    OriGene ORF clones in mouse, rat for TRIB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIB3 (NM_021158)
    Sino Biological Human cDNA Clone for TRIB3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIB3
    Sirion Biotech Customized lentivirus for stable overexpression of TRIB3 
                         Customized lentivirus expression plasmids for stable overexpression of TRIB3 

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    Search LifeMap BioReagents cell lines for TRIB3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIB3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRIB3 About   (see all 14)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83
    2PIP3 activates AKT signaling
    GAB1 signalosome0.93
    PI3K events in ERBB2 signaling0.88
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    PI-3K cascade0.88
    Signaling by ERBB40.67
    3IRS-related events
    Insulin receptor signalling cascade0.94
    IGF1R signaling cascade0.92
    IRS-related events0.94
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    IRS-related events triggered by IGF1R0.93
    PI3K Cascade0.86
    IRS-mediated signalling0.92
    Signaling by Insulin receptor0.79
    4Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56
    5Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.74
    Fatty acid, triacylglycerol, and ketone body metabolism0.52
    PPARA Activates Gene Expression0.74

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for TRIB3
        Insulin Signaling
    Adipogenesis

    1 Sino Biological Pathway for TRIB3 
        Notch Signaling Pathway

    5/45        Reactome Pathways for TRIB3 (see all 45)
        Activation of PKB
    Signaling by EGFR in Cancer
    Negative regulation of the PI3K/AKT network
    Fatty acid, triacylglycerol, and ketone body metabolism
    Downstream signal transduction



    TRIB3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRIB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/56 Interacting proteins for TRIB3 (Q96RU71, 2, 3 ENSP000002172334) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS6Q7L5N12, 3MINT-64345 I2D: score=5 
    EEF1GP266412, 3MINT-64343 I2D: score=5 
    GDF9O603832, 3MINT-64342 I2D: score=5 
    GIT1Q9Y2X72, 3MINT-64348 I2D: score=5 
    KAT5Q929932, 3MINT-64346 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006468protein phosphorylation IEA--
    GO:0006469negative regulation of protein kinase activity IDA12791994
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0008286insulin receptor signaling pathway TAS--

    TRIB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRIB3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIB3

    1 Novoseek inferred chemical compound relationship for TRIB3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 7.53 16 16835403 (7), 19996382 (2), 16129579 (2), 19291425 (1)

    Search CenterWatch for drugs/clinical trials and news about TRIB3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRIB3 gene: 
    NM_021158.3  

    Unigene Cluster for TRIB3:

    Tribbles homolog 3 (Drosophila)
    Hs.516826  [show with all ESTs]
    Unigene Representative Sequence: AY247738
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000217233(uc002wdm.3 uc002wdn.3) ENST00000449710 ENST00000485293
    ENST00000422053
    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIB3 (see all 11):
    hsa-miR-4254 hsa-miR-1271 hsa-miR-146a* hsa-miR-124 hsa-miR-182 hsa-miR-3116 hsa-miR-1207-3p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidTRIB3 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIB3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIB3

    Additional mRNA sequence: 

    AF250311.1 AJ697936.1 AJ697939.1 AJ697940.1 AK026945.1 AK222837.1 AK297546.1 AY247738.1 
    BC019363.1 BC027484.1 CR457366.1 

    17 DOTS entries:

    DT.213124  DT.100643136  DT.100677638  DT.100848760  DT.92052029  DT.95302657  DT.120807980  DT.100643138 
    DT.99960323  DT.91931641  DT.95318567  DT.100029901  DT.100643137  DT.100847596  DT.95318544  DT.100879408 
    DT.97762522 

    24/304 AceView cDNA sequences (see all 304):

    AW674640 AA330920 AI393047 CR609787 BP353069 BE858443 AW328450 BM788483 
    BG387820 BM453726 BF026145 BP430298 AI591018 AW673836 AI559956 CF242813 
    BM792151 NM_021158 BM765228 BM765164 AA379659 AY247738 BF062648 BM764986 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TRIB3 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c
    SP1:              -     -     -     -     -     -           -                                             
    SP2:              -     -     -     -     -     -                                                         
    SP3:                                -     -     -                                                         
    SP4:                                            -                                                         
    SP5:                                      -     -                                                         


    ECgene alternative splicing isoforms for TRIB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIB3 expression in normal human tissues (normalized intensities)      TRIB3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTATGTATG
    TRIB3 Expression
    About this image


    TRIB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Fibroblast
             Human Prostate Fibroblasts (HPrF)   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Basal Cells Respiratory Bronchioles
             Human Bronchial Smooth Muscle Cells (HBSM)   
     
     Uterus (Reproductive System)    fully expand to see all 2 entries
             cervix   
     
     Smooth Muscle (Muscoskeletal System)
             Human Bronchial Smooth Muscle Cells (HBSM)   
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor

    See TRIB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIB3

    SOURCE GeneReport for Unigene cluster: Hs.516826

    UniProtKB/Swiss-Prot: TRIB3_HUMAN, Q96RU7
    Tissue specificity: Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also
    highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate
    and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart,
    brain, placenta, lung, skeletal muscle, and kidney

        SABiosciences Expression via Pathway-Focused PCR Array including TRIB3: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TRIB3 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trib31 , 5 tribbles homolog 3 (Drosophila)1, 5 76.84(n)1
    74.58(a)1
      2 (74.83 cM)5
    2287751  NM_175093.21  NP_780302.21 
     1523374225 
    lizard
    (Anolis carolinensis)
    Reptilia TRIB36
    Uncharacterized protein
    60(a)
    1 ↔ 1
    GL343346.1(1052507-1054239)
    zebrafish
    (Danio rerio)
    Actinopterygii trib31 tribbles homolog 3 (Drosophila) 55.69(n)
    52.87(a)
      405805  NM_212869.1  NP_998034.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta trbl6
    tribbles
    20(a)
    1 → many
    3L(20389388-20394709)
    worm
    (Caenorhabditis elegans)
    Secernentea nipi-36
    Protein NIPI-3
    12(a)
    1 → many
    X(15607969-15610631)


    ENSEMBL Gene Tree for TRIB3 (if available)
    TreeFam Gene Tree for TRIB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIB3 gene
    BRSK12  STK402  TRIB22  BRSK22  TRIB12  
    5 SIMAP similar genes for TRIB3 using alignment to 3 protein entries:     TRIB3_HUMAN (see all proteins):
    MARK4    TRIB1    TRIB2    NUAK1    RPS6KA2

    TRIB3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/556 SNPs in TRIB3 are shown (see all 556)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0423724
    A glioblastoma multiforme sample4--see VAR_0423722 T I mis40--------
    rs770230581,2
    F--359312(+) CTCCCA/GTCCAG 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs713280541,2
    C--359344(+) TTATTC/TTATTT 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs613252671,2
    C,F--359373(+) GAGACG/AGAGTC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1910943131,2
    --359498(+) GTGTGC/TTTTTT 1 -- us2k10--------
    rs61330111,2
    C,F--359551(+) CACCGT/AGTTAG 1 -- us2k12Minor allele frequency- A:0.50NA CSA 4
    rs1174998791,2
    F--359664(+) TATTTT/GACTTA 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs60842621,2
    C,F,A--359674(+) acttaT/Cttatt 1 -- us2k1 tfbs39Minor allele frequency- C:0.30NA WA CSA EA 369
    rs736021091,2
    C--359780(+) CTCCTA/GCCTCA 1 -- us2k10--------
    rs1118089661,2
    C,F--360005(+) AAAAGG/CGATTT 1 -- us2k12Minor allele frequency- C:0.04NA 122

    HapMap Linkage Disequilibrium report for TRIB3 (361261 - 378203 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for TRIB3 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2657243CNV Deletion23128226
    esv2057444CNV Deletion18987734
    dgv773e199CNV Deletion23128226
    nsv510777CNV Loss20534489
    nsv912563CNV Loss21882294
    nsv519415CNV Loss19592680
    nsv458842CNV Loss19166990
    nsv912559CNV Loss21882294
    nsv458839CNV Loss19166990
    nsv458841CNV Loss19166990


    Human Gene Mutation Database (HGMD): TRIB3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607898    OMIM disorders: --

    13 diseases for TRIB3:    About MalaCards
    anoxia    neuronitis    insulin resistance    polycystic ovary syndrome
    hypoxia    diabetes mellitus    atherosclerosis    obesity
    colorectal cancer    endotheliitis    hepatitis    prostatitis
    breast cancer


    TRIB3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TRIB3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin resistance 40.5 11 19996382 (3), 16123373 (3), 16835403 (2), 18436806 (1) (see all 5)
    tumors 0 6 12743605 (4), 12736262 (1)

    Genetic Association Database (GAD): TRIB3
    Human Genome Epidemiology (HuGE) Navigator: TRIB3 (13 documents)

    Export disorders for TRIB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIB3 gene, integrated from 9 sources (see all 80):
    (articles sorted by number of sources associating them with TRIB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TRB3 is a PI 3-kinase dependent indicator for nutrient starvation. (PubMed id 16129579)1, 2, 9 Schwarzer R.... Kaufmann J. (2006)
    2. SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia. (PubMed id 12743605)1, 2, 9 Bowers A.J.... Boylan J.F. (2003)
    3. Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions. (PubMed id 15781252)1, 2, 9 Ord D. and Ord T. (2005)
    4. TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. (PubMed id 15775988)1, 2, 9 Ohoka N....Hayashi H. (2005)
    5. SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription. (PubMed id 12736262)1, 2, 9 Wu M.... Shu H.B. (2003)
    6. The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy. (PubMed id 16123373)1, 4, 9 Prudente S....Trischitta V. (2005)
    7. Association of TRB3 gene Q84R polymorphism with type 2 diabetes mellitus in Chinese population. (PubMed id 19291425)1, 4, 9 Shi Z....Zhang J. (2009)
    8. Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A. (PubMed id 22977230)1, 2 Aynaud M.M.... Vartanian J.P. (2012)
    9. TRIB3 R84 variant affects glucose homeostasis by alte ring the interplay between insulin sensitivity and secretion. (PubMed id 20393693)1, 4 Prudente S....Frittitta L. (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57761 HGNC: 16228 AceView: TRIB3 Ensembl:ENSG00000101255 euGenes: HUgn57761
    ECgene: TRIB3 H-InvDB: TRIB3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRIB3 gene:
    Search GeneIP for patents involving TRIB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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