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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIB3 Gene

protein-coding   GIFtS: 63
GCID: GC20P000361

tribbles homolog 3 (Drosophila)

(Previous name: chromosome 20 open reading frame 97 )
(Previous symbol: C20orf97)
 Explore 15 diseases affiliated with
TRIB3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRIB3    

Aliases
for TRIB3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tribbles Homolog 3 (Drosophila)1 2     TRB-32 3
C20orf971 2 3     P65-Interacting Inhibitor Of NF-Kappa-B2 3
TRB31 2 3     Chromosome 20 Open Reading Frame 971
Neuronal Cell Death-Inducible Putative Kinase2 3     DJ1103G7.31
NIPK2 3     Neuronal Cell Death Inducible Putative Kinase2
SINK2 3     P65-Interacting Inhibitor Of NF-KappaB2
SKIP32 3     Tribbles Homolog 32

External Ids:    HGNC: 162281   Entrez Gene: 577612   Ensembl: ENSG000001012557   OMIM: 6078985   UniProtKB: Q96RU73   

Export aliases for TRIB3 gene to outside databases

Previous GC identifers: GC20P000357 GC20P000309


Summaries
for TRIB3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TRIB3:
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB.
The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced
apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. (provided
by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TRIB3_HUMAN, Q96RU7
Function: Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind
directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional
activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus
its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play
a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase
activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death
during ER stress. Can inhibit APOBEC3A editing of nuclear DNA

Gene Wiki entry for TRIB3


Genomic Views
for TRIB3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIB3 gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRIB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13-p12.2   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13-p12.2

TRIB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIB3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P000361:  view genomic region     (about GC identifiers)

Start:
 361,261 bp from pter      End:
 378,203 bp from pter
Size:
 16,943 bases      Orientation:
 plus strand

Proteins
for TRIB3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TRIB3_HUMAN, Q96RU7 (See protein sequence)
Recommended Name: Tribbles homolog 3  
Size: 358 amino acids; 39578 Da
Subunit: Interacts with AKT1, AKT2, ATF4, MAP2K1 and MAP2K7. Interacts with DDIT3/CHOP and inhibits its interaction
with EP300/P300. Interacts (via N-terminus) with APOBEC3A. Interacts with APOBEC3C
Subcellular location: Nucleus
Caution: The role of this protein in Akt activation has been demonstrated by Du et al (PubMed:12791994) for the mouse
ortholog but Iynedjian (PubMed:15469416) has not been able to reproduce the result in rat hepatocytes
Secondary accessions: Q53GU4 Q53ZW7 Q6I9Y9 Q8TAI6 Q9H5M8 Q9NUD2

Explore the universe of human proteins at neXtProt for TRIB3: NX_Q96RU7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96RU7

    • TRIB3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_066981.2  
    ENSEMBL proteins: 
     ENSP00000217233   ENSP00000391873   ENSP00000415416  
    Reactome Protein details: Q96RU7
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: TRIB3
    OriGene Custom Protein Services for TRIB3 
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    Novus Biologicals TRIB3 Proteins
    Novus Biologicals TRIB3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TRIB3

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--


    TRIB3 for ontologies           About GeneDecksing



    TRIB3 Antibody Products: 
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    ThermoFisher Antibodies for TRIB3

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    Uscn ELISAs and CLIAs for TRIB3

    Protein Domains /
    Families
    for TRIB3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRIB3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR024104 Tribbles/Ser_Thr_kinase_40
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR024106 Tribbles_TRB3

    Graphical View of Domain Structure for InterPro Entry Q96RU7

    ProtoNet protein and cluster: Q96RU7

    UniProtKB/Swiss-Prot: TRIB3_HUMAN, Q96RU7
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for TRIB3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TRIB3_HUMAN, Q96RU7
    Function: Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind
    directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional
    activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus
    its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play
    a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase
    activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death
    during ER stress. Can inhibit APOBEC3A editing of nuclear DNA
    Induction: By hypoxia, TNF, and by nutrient starvation. Expression is PI 3-kinase and/or NF-kappa-B-dependent. Induced
    by ER stress via ATF4-DDIT3/CHOP pathway and can downregulate its own induction by repression of ATF4-DDIT3/CHOP
    functions

    miRNA
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    hsa-mir-24 (MIRT003354)

    OriGene 3'-UTR Clone: TRIB3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIB3
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIB3 (see all 11):
    hsa-miR-4254 hsa-miR-1271 hsa-miR-146a* hsa-miR-124 hsa-miR-182 hsa-miR-3116 hsa-miR-1207-3p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmid: TRIB3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIB3 (see all 7)
    OriGene shRNA RFP: TRIB3
    OriGene siRNA: TRIB3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIB3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TRIB3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIB3 (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TRIB3 (NM_021158)
    Sino Biological Human cDNA Clone for TRIB3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIB3 

    Cell Line
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    Search LifeMap BioReagents cell lines for TRIB3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIB3

    Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity ISS--
    GO:0004672protein kinase activity ----
    GO:0004860protein kinase inhibitor activity IEA--
    GO:0005515protein binding IPI12743605
    GO:0005524ATP binding IEA--


    TRIB3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for TRIB3:
     Decreased substrate adherent c  Upregulation of NF-kappaB path 

    Animal Models:
         Mouse knock-out Trib3tm1Mws for TRIB3
         5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Trib3):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  limbs/digits/tail  normal 

    TRIB3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TRIB3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    2PIP3 activates AKT signaling
    8/9 pathways (see all 9)
    		PIP3 activates AKT signaling1.00
    		PI3K/AKT activation0.97
    		PI3K/AKT Signaling in Cancer1.00
    		GAB1 signalosome0.96
    		PI3K events in ERBB2 signaling1.00
    		Signaling by SCF-KIT0.72
    		PI3K events in ERBB4 signaling1.00
    		Signaling by ERBB40.67
    3IRS-related events
    		IRS-related events1.00
    		Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.90
    		IRS-mediated signalling0.98
    		IGF1R signaling cascade0.90
    		Insulin receptor signalling cascade0.94
    		PI3K Cascade0.84
    		IRS-related events triggered by IGF1R0.93
    		Signaling by Insulin receptor0.74
    4Immune System
    		Immune System1.00
    		Innate Immune System0.46
    		Adaptive Immune System0.59
    5Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)1.00
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52
    		PPARA Activates Gene Expression0.74

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for TRIB3 
        Adipogenesis
    Insulin Signaling

    5/44        Reactome Pathways for TRIB3 (see all 44)
        Activation of PKB
    Signaling by EGFR in Cancer
    Negative regulation of the PI3K/AKT network
    Fatty acid, triacylglycerol, and ketone body metabolism
    Downstream signal transduction



    TRIB3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRIB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/51 Interacting proteins for TRIB3 (Q96RU71, 2, 3 ENSP000002172334) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS6Q7L5N12, 3MINT-64345 I2D: score=5 
    EEF1GP266412, 3MINT-64343 I2D: score=5 
    GDF9O603832, 3MINT-64342 I2D: score=5 
    GIT1Q9Y2X72, 3MINT-64348 I2D: score=5 
    KAT5Q929932, 3MINT-64346 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006468protein phosphorylation IEA--
    GO:0006469negative regulation of protein kinase activity IDA12791994
    GO:0006915apoptotic process ----


    TRIB3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRIB3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRIB3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIB3
    1 Novoseek chemical compound relationship for TRIB3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 7.53 16 16835403 (7), 19996382 (2), 16129579 (2), 19291425 (1)

    Search CenterWatch for drugs/clinical trials and news about TRIB3 

    Transcripts
    for TRIB3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRIB3 gene: 
    NM_021158.3  

    Unigene Cluster for TRIB3:

    Tribbles homolog 3 (Drosophila)
    Hs.516826  [show with all ESTs]
    Unigene Representative Sequence: AY247738
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000217233(uc002wdm.3 uc002wdn.3) ENST00000449710 ENST00000485293
    ENST00000422053

    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIB3 (see all 11):
    hsa-miR-4254 hsa-miR-1271 hsa-miR-146a* hsa-miR-124 hsa-miR-182 hsa-miR-3116 hsa-miR-1207-3p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmid: TRIB3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIB3 (see all 7)
    OriGene shRNA RFP: TRIB3
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    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIB3

    Additional cDNA sequence: 

    AF250311.1 AJ697936.1 AJ697939.1 AJ697940.1 AK026945.1 AK222837.1 AK297546.1 AY247738.1 
    BC019363.1 BC027484.1 CR457366.1 

    17 DOTS entries:

    DT.213124  DT.100643136  DT.100677638  DT.100848760  DT.92052029  DT.95302657  DT.120807980  DT.100643138 
    DT.99960323  DT.91931641  DT.95318567  DT.100029901  DT.100643137  DT.100847596  DT.95318544  DT.100879408 
    DT.97762522 

    24/304 AceView cDNA sequences (see all 304):

    BM772759 BM907602 BM453726 BF026145 BP430298 AI591018 AI934772 AW674640 
    BP353043 CR609787 BQ679971 CA417146 BF062648 AW673836 AI400049 BF969188 
    BM765164 BM764986 AA564024 CF242813 AI559956 BP353069 CA495347 AI347550 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TRIB3 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c
    SP1:              -     -     -     -     -     -           -                                             
    SP2:              -     -     -     -     -     -                                                         
    SP3:                                -     -     -                                                         
    SP4:                                            -                                                         
    SP5:                                      -     -                                                         


    ECgene alternative splicing isoforms for TRIB3

    Expression
    for TRIB3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTATGTATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TRIB3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungRespiratory BronchiolesBasal CellsLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

    See TRIB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIB3

    SOURCE GeneReport for Unigene cluster: Hs.516826

    UniProtKB/Swiss-Prot: TRIB3_HUMAN, Q96RU7
    Tissue specificity: Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly
    expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is
    undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain,
    placenta, lung, skeletal muscle, and kidney

        SABiosciences Expression via Pathway-Focused PCR Array including TRIB3: 
              Diabetes in human mouse rat

    Primer
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    Orthologs
    for TRIB3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TRIB3 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia TRIB36
    		 --
    		 60(a)
    		 1 ↔ 1
    		 GL343346.1(1052507-1053985)
    zebrafish
    (Danio rerio)    		 Actinopterygii trib31 tribbles homolog 3 (Drosophila) 55.69(n)
    52.87(a)    		   405805  NM_212869.1  NP_998034.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta trbl6
    		 tribbles
    		 20(a)
    		 1 → many
    		 3L(20389388-20394709)
    worm
    (Caenorhabditis elegans)    		 Secernentea nipi-36
    		 No Induction of Peptide after Drechmeria Infection...
    		 9(a)
    		 possible ortholog
    		 X(15607901-15610563)


    ENSEMBL Gene Tree for TRIB3 (if available)
    TreeFam Gene Tree for TRIB3 (if available) 

    Paralogs
    for TRIB3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIB3 gene
    STK402  TRIB22  TRIB12  
    6 SIMAP similar genes for TRIB3 using alignment to 3 protein entries:     TRIB3_HUMAN (see all proteins):
    MARK4    TRIB1    TRIB2    NUAK1    RPS6KA2    MAPKAPK5

    TRIB3 for paralogs           About GeneDecksing



    Genomic Variants
    for TRIB3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/478 NCBI SNPs in TRIB3 are shown (see all 478)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs770230581,2
    		F,--359312(+) CTCCCA/GTCCAG 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs713280541,2
    		C--359344(+) TTATTC/TTATTT 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs613252671,2
    		--359373(+) GAGACG/AGAGTC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1910943131,2
    		--359498(+) GTGTGC/TTTTTT 1 -- us2k10--------
    rs61330111,2
    		C,F,--359551(+) CACCGT/AGTTAG 1 -- us2k12Minor allele frequency- A:0.50NA CSA 4
    rs1174998791,2
    		F,--359664(+) TATTTT/GACTTA 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs60842621,2
    		C,F,A,--359674(+) ACTTAT/CTTATT 1 -- us2k1 tfbs39Minor allele frequency- C:0.30NA WA CSA EA 369
    rs736021091,2
    		C--359780(+) CTCCTA/GCCTCA 1 -- us2k10--------
    rs1118089661,2
    		C,--360005(+) AAAAGG/CGATTT 1 -- us2k12Minor allele frequency- C:0.04NA 122
    rs72652911,2
    		C,F,H,--360042(+) GGCGCA/GGTGGC 1 -- us2k16Minor allele frequency- G:0.27WA NA CSA 11

    HapMap Linkage Disequilibrium report for TRIB3 (361261 - 378203 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for TRIB3
         2 CNVs: 30117 50649
         1 Indel: 46090
    Human Gene Mutation Database (HGMD): TRIB3

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    Disorders / Diseases
    for TRIB3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRIB3 for disorders           About GeneDecksing

    OMIM gene information: 607898    OMIM disorders: --

    15 diseases for TRIB3:    About MalaCards
    type 2 diabetes mellitus    neuronitis    polycystic ovary syndrome    insulin resistance
    diabetes mellitus    anoxia    liver cancer    homocysteine
    colorectal cancer    atherosclerosis    obesity    cholesterol
    hypoxia    hepatitis    prostatitis

    2 Novoseek disease relationships for TRIB3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin resistance 40.5 11 19996382 (3), 16123373 (3), 16835403 (2), 18436806 (1) (see all 5)
    tumors 0 6 12743605 (4), 12736262 (1)

    Genetic Association Database (GAD): TRIB3
    Human Genome Epidemiology (HuGE) Navigator: TRIB3 (13 documents)

    Export disorders for TRIB3 gene to outside databases

    Publications
    for TRIB3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIB3 gene, integrated from 9 sources (see all 73):
    (articles sorted by number of sources associating them with TRIB3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. TRB3 is a PI 3-kinase dependent indicator for nutrient starvation. (PubMed id 16129579)1, 2, 9 Schwarzer R.... Kaufmann J. (2006)
    2. SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia. (PubMed id 12743605)1, 2, 9 Bowers A.J.... Boylan J.F. (2003)
    3. Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions. (PubMed id 15781252)1, 2, 9 Ord D. and Ord T. (2005)
    4. TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. (PubMed id 15775988)1, 2, 9 Ohoka N....Hayashi H. (2005)
    5. SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription. (PubMed id 12736262)1, 2, 9 Wu M.... Shu H.B. (2003)
    6. The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy. (PubMed id 16123373)1, 4, 9 Prudente S....Trischitta V. (2005)
    7. Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A. (PubMed id 22977230)1, 2 Aynaud M.M.... Vartanian J.P. (2012)
    8. Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion. (PubMed id 17872950)1, 2 Ohoka N....Hayashi H. (2007)
    9. Tribbles: novel regulators of cell function; evolutio nary aspects. (PubMed id 16715410)1, 3 Hegedus Z....Kiss-Toth E. (2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    External Searches for TRIB3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TRIB3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57761 HGNC: 16228 AceView: TRIB3 Ensembl:ENSG00000101255 euGenes: HUgn57761
    ECgene: TRIB3 H-InvDB: TRIB3

    Other Databases showing TRIB3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TRIB3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIB3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TRIB3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TRIB3 gene:
    Search GeneIP for patents involving TRIB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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