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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRIB2 Gene

protein-coding GIFtS: 54
GCID: GC02P012807

tribbles homolog 2 (Drosophila)

Explore 10 diseases affiliated with
TRIB2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Tribbles Homolog 2 (Drosophila)¹ ²
TRB2¹ ² ³
GS3955¹ ²
C5FW²
Tribbles Homolog 2²
TRB-2³

External Ids:	HGNC: 30809¹	Entrez Gene: 28951²	Ensembl: ENSG00000071575⁷	OMIM: 609462⁵	UniProtKB: Q92519³

ORGUL members:
	NONCODE:n338680 n407780

Export aliases for TRIB2 gene to outside databases

Previous GC identifers: GC02P012879 GC02P012706

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRIB2:

This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is

homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic

function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of

physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic

origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as

an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes

acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. (provided by

RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: TRIB2_HUMAN, Q92519

Function: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By

similarity)

Gene Wiki entry for TRIB2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005334.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRIB2 gene promoter:
RP58 Lmo2 Olf-1 AP-4 Evi-1 C/EBPalpha POU2F1 CP2 ARP-1 c-Myb
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRIB2 promoter sequence

Search SABiosciences Chromatin IP Primers for TRIB2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24.3 Ensembl cytogenetic band: 2p24.3 HGNC cytogenetic band: 2p25.1

TRIB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIB2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P012807: view genomic region (about GC identifiers)

Start:	12,856,998 bp from pter	End:	12,882,860 bp from pter
Size:	25,863 bases	Orientation:	plus strand

ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TRIB2

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRIB2_HUMAN, Q92519 (See protein sequence)

Recommended Name: Tribbles homolog 2

Size: 343 amino acids; 38801 Da

Subcellular location: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=May associate with the

cytoskeleton (By similarity)

Miscellaneous: Antibodies against TRIB2 are present in sera from patients with autoimmune uveitis

Secondary accessions: B2R851 D6W510

Explore the universe of human proteins at neXtProt for TRIB2: NX_Q92519

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92519

TRIB2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_067675.1

ENSEMBL proteins:

ENSP00000155926 ENSP00000370874 ENSP00000384260

Human Recombinant Protein Products for TRIB2:

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	Novus Biologicals TRIB2 Proteins Novus Biologicals TRIB2 Lysates
	Sino Biological Recombinant Protein for TRIB2
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TRIB2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	ISS	--
GO:0005856	cytoskeleton	IEA	--

TRIB2 for ontologies About GeneDecksing

TRIB2 Antibody Products:

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	Uscn Antibodies for TRIB2
	ThermoFisher Antibodies for TRIB2

Assay Products for TRIB2:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TRIB2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TRIB2 for domains About GeneDecksing

3 InterPro domains/families:

IPR024104 Tribbles/Ser_Thr_kinase_40

IPR011009 Kinase-like_dom

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry Q92519

ProtoNet protein and cluster: Q92519

UniProtKB/Swiss-Prot: TRIB2_HUMAN, Q92519

Domain: The protein kinase domain is predicted to be catalytically inactive

Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TRIB2_HUMAN, Q92519

Function: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By

similarity)

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	NOT nucleotide binding	ISS	--
GO:0004672	NOT protein kinase activity	ISS	--
GO:0004860	protein kinase inhibitor activity	IEA	--
GO:0005524	ATP binding	--	--
GO:0008134	transcription factor binding	ISS	17576771

TRIB2 for ontologies About GeneDecksing

Phenotypes:
6 GenomeRNAi human phenotypes for TRIB2:

Decreased CYP1A1 activity afte	Decreased Hepatitis C virus re	Decreased focal adhesion (FA)	Decreased influenza A/WSN/33 r
Decreased substrate adherent c	Increased Salmonella enterica

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Trib2):

behavior/neurological

hematopoietic system

immune system

normal

TRIB2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Trib2^tm1Lex for TRIB2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TRIB2

miRNA Products:		OriGene 3'-UTR Clone: TRIB2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIB2
		8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIB2 (see all 65):
		hsa-miR-219-1-3p hsa-miR-193a-3p hsa-let-7d hsa-miR-3616-5p hsa-miR-485-3p hsa-miR-29a hsa-let-7g hsa-miR-374c

		SwitchGear 3'UTR luciferase reporter plasmid: TRIB2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIB2 (see all 7) OriGene shRNA RFP: TRIB2 OriGene siRNA: TRIB2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIB2
		Sirion Biotech Custom design and validation of potent shRNA sequences against TRIB2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TRIB2
			Sirion Biotech Customized adenovirus for overexpression of TRIB2 Sirion Biotech Customized adenovirus for potent knockdown of TRIB2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIB2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIB2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TRIB2 (NM_021643)
		Sino Biological Human cDNA Clone for TRIB2
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIB2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TRIB2
		Search LifeMap BioReagents cell lines for TRIB2
		Sirion Biotech Customized stable knockdown cell line services for TRIB2 Sirion Biotech Customized inducible knockdown cell line services for TRIB2 Sirion Biotech Customized stable overexpressing cell line services for TRIB2 Sirion Biotech Customized inducible overexpressing cell line services for TRIB2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIB2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TRIB2

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for TRIB2 (Q92519^{2, 3} ENSP00000155926⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBQLN4	Q9NRR5²^,³, ENSP00000357292⁴	MINT-2872241 I2D: score=3 STRING: ENSP00000357292
SLAMF7	ENSP00000357022⁴	STRING: ENSP00000357022

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	NOT protein phosphorylation	ISS	--
GO:0006469	negative regulation of protein kinase activity	NAS	12791994
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS	--
GO:0043405	regulation of MAP kinase activity	ISS	--
GO:0045081	negative regulation of interleukin-10 biosynthetic process	IMP	18643775

TRIB2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRIB2
Search CenterWatch for drugs/clinical trials and news about TRIB2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRIB2 gene:

NM_021643.3

Unigene Cluster for TRIB2:

Tribbles homolog 2 (Drosophila)

Hs.467751 [show with all ESTs]

Unigene Representative Sequence: NM_021643

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000155926(uc002rbv.4 uc010yjp.2) ENST00000483034 ENST00000381465

ENST00000405331

miRNA Products:		OriGene 3'-UTR Clone: TRIB2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIB2
		8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIB2 (see all 65):
		hsa-miR-219-1-3p hsa-miR-193a-3p hsa-let-7d hsa-miR-3616-5p hsa-miR-485-3p hsa-miR-29a hsa-let-7g hsa-miR-374c

		SwitchGear 3'UTR luciferase reporter plasmid: TRIB2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIB2
		Sirion Biotech Custom design and validation of potent shRNA sequences against TRIB2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIB2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIB2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TRIB2 (NM_021643)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIB2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIB2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIB2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TRIB2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIB2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIB2

Additional cDNA sequence:

AK129973.1 AK299146.1 AK313237.1 AY245544.1 BC002637.2 D87119.1 NR_027303.1

17 DOTS entries:

DT.450629 DT.100703781 DT.100026118 DT.121031532 DT.121031473 DT.121031529 DT.100802413 DT.92050383

DT.40116032 DT.92450466 DT.92450469 DT.100802411 DT.100802407 DT.118857 DT.121031454 DT.100772452

DT.121031487

24/263 AceView cDNA sequences (see all 263):

W03028 BE046502 CR614490 BU182685 AA386314 BM665997 AI015721 BQ636172

BX364584 BM711648 Z44385 AA677975 AY245544 BG055992 BQ221000 AA363914

AA809280 AW408806 N72285 AI984361 BQ213118 AI014458 BG236851 CK906186

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for TRIB2 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5
SP1:													-
SP2:					-
SP3:

ECgene alternative splicing isoforms for TRIB2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRIB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGGGATCT

About this image

TRIB2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Visceral White Preadipocytes

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Mature follicles (In-vitro growth and ...)

See TRIB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIB2

SOURCE GeneReport for Unigene cluster: Hs.467751

UniProtKB/Swiss-Prot: TRIB2_HUMAN, Q92519

Tissue specificity: Highly expressed in peripheral blood leukocytes

SABiosciences Custom PCR Arrays for TRIB2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIB2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIB2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TRIB2 gene from 6/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TRIB2¹	tribbles homolog 2 (Drosophila)	84.16(n) 95.63(a)		378919 NM_204401.2 NP_989732.2
lizard (Anolis carolinensis)	Reptilia	TRIB2⁶	--	88(a)	1 ↔ 1	1(146232279-146258714)
African clawed frog (Xenopus laevis)	Amphibia	AB109102.1²	--	80.59(n)		AB109102.1
zebrafish (Danio rerio)	Actinopterygii	trib2¹	tribbles homolog 2 (Drosophila)	71.53(n) 77.84(a)		100331041 XM_002667743.1 XP_002667789.1
fruit fly (Drosophila melanogaster)	Insecta	trbl¹	tribbles	53.62(n) 44.35(a)		43999 NM_079933.3 NP_524672.1
worm (Caenorhabditis elegans)	Secernentea	nipi-3⁶	No Induction of Peptide after Drechmeria Infection...	9(a)	possible ortholog	X(15607901-15610563)

ENSEMBL Gene Tree for TRIB2 (if available)
TreeFam Gene Tree for TRIB2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TRIB2 gene

STK40² TRIB3² TRIB1²

18/26 SIMAP similar genes for TRIB2 using alignment to 3 protein entries: TRIB2_HUMAN (see all proteins) (see all similar genes):

TRIB1 MARK4 TRIB3 MELK BRSK2 STK33

CAMK2D MAPKAPK3 PLK4 AKT1 AKT2 CAMK2B

MARK2 MAPKAPK5 NUAK1 RPS6KA3 MARK3 RPS6KA1

TRIB2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs59216273^1,2	F	--	12704743(+)	`CCTGAC/GGTTCA`	2	--	us2k¹		1	WA	118
rs7593863^1,2	C,F,H	--	12705442(+)	`AGTCAA/GTGTCC`	2	--	us2k¹		9	NS EA NA WA	1202
rs79632638^1,2	C,F	--	12706223(+)	`CGATGA/CAAGCG`	2	--	us2k¹		1	WA	118
rs75439400^1,2		--	12706254(+)	`CCTCAT/ATCAGG`	2	--	us2k¹		2	CSA WA	120
rs28969622^1,2	C,F	--	12706473(+)	`CGCCCG/CGGGCC`	2	--	us2k¹		1	EA	120
rs74429569^1,2	F	--	12706990(+)	`CAAGCC/GGTCAA`	2	--	ut5¹ int¹		1	WA	118
rs11904706^1,2	C,F,H	--	12707313(+)	`GAGCCC/TAGGGC`	2	--	ut5¹ int¹ ese³		6	NS NA WA	628
rs77773048^1,2	C	--	12707772(+)	`CTGGCG/ACTGCA`	2	--	ut5¹ int¹		2	NA	122
rs7590994^1,2	C,F	--	12708021(+)	`CCTCTC/TGCTCC`	2	--	ut5¹ int¹ ese³ trp³		1	WA	118
rs10929829^1,2	C,F	--	12709153(+)	`AGGGAT/CCCGCA`	2	--	int¹		4	NA WA	242

HapMap Linkage Disequilibrium report for TRIB2 (12856998 - 12882860 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TRIB2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIB2

DNA2.0 Custom Variant and Variant Library Synthesis for TRIB2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRIB2 for disorders           About GeneDecksing

OMIM gene information: 609462    OMIM disorders: --

10 diseases for TRIB2:    About MalaCards

leukemia conduct disorder hypertriglyceridemia multiple sclerosis

uveitis narcolepsy lung cancer ataxia

thyroiditis melanoma

Human Genome Epidemiology (HuGE) Navigator: TRIB2 (3 documents)

Export disorders for TRIB2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TRIB2 gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with TRIB2)

Utopia: connect your pdf to the dynamic
world of online information

Tribbles: novel regulators of cell function; evolutio nary aspects. (PubMed id 16715410)^{1, 3} Hegedus Z....Kiss-Toth E. (2006)
Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia. (PubMed id 17097562)^{1, 3} Keeshan K....Pear W.S. (2006)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display. (PubMed id 15950723)^{1, 2} Zhang Y.... Li W. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. (PubMed id 15299019)^{1, 2} Kiss-Toth E.... Dower S.K. (2004)
SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription. (PubMed id 12736262)^{1, 3} Wu M.... Shu H.B. (2003)
Human tribbles homologue 2 is expressed in unstable regions of carotid plaques and regulates macrophage IL-10 in vitro. (PubMed id 18643775)^{1, 9} Deng J....Davis B. (2009)
Survival factor withdrawal-induced apoptosis of TF-1 cells involves a TRB2-Mcl-1 axis-dependent pathway. (PubMed id 17545167)^{1, 9} Lin K.R....Yen J.J. (2007)
Tribbles-1 and -2 are tumour suppressors, down-regula ted in human acute myeloid leukaemia. (PubMed id 20005259)^{1, 9} Gilby D.C....Kiss-Toth E. (2010)

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Entrez Gene: 28951	HGNC: 30809	AceView: TRIB2	Ensembl:ENSG00000071575	euGenes: HUgn28951
ECgene: TRIB2	H-InvDB: TRIB2

(According to HUGE)
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tribbles homolog 2 (Drosophila)

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TRIB2 Gene

tribbles homolog 2 (Drosophila)

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