Aliases for TRIB2 Gene
External Ids for TRIB2 Gene
Previous GeneCards Identifiers for TRIB2 Gene
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
GeneCards Summary for TRIB2 Gene
TRIB2 (Tribbles Pseudokinase 2) is a Protein Coding gene. Diseases associated with TRIB2 include Uveitis and Narcolepsy. Among its related pathways are NF-kappaB Signaling and Wnt / Hedgehog / Notch. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TRIB1.
UniProtKB/Swiss-Prot for TRIB2 Gene
Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).