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TRIB2 Gene

protein-coding   GIFtS: 57
GCID: GC02P012856

Tribbles Pseudokinase 2

(Previous name: tribbles homolog 2 (Drosophila))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tribbles Pseudokinase 21 2     GS39552
TRB22 3     Tribbles Homolog 22
Tribbles Homolog 2 (Drosophila)1     TRB-23
C5FW2     

External Ids:    HGNC: 308091   Entrez Gene: 289512   Ensembl: ENSG000000715757   OMIM: 6094625   UniProtKB: Q925193   

Export aliases for TRIB2 gene to outside databases

Previous GC identifers: GC02P012879 GC02P012807 GC02P012706


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIB2 Gene:
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is
homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic
function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of
physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the
hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1)
cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding
protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found
for this gene. (provided by RefSeq, Mar 2009)

GeneCards Summary for TRIB2 Gene:
TRIB2 (tribbles pseudokinase 2) is a protein-coding gene. GO annotations related to this gene include protein kinase activity and nucleotide binding. An important paralog of this gene is STK40.

UniProtKB/Swiss-Prot: TRIB2_HUMAN, Q92519
Function: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity
(By similarity)

Gene Wiki entry for TRIB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005334.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIB2 gene promoter:
         RP58   Lmo2   Olf-1   AP-4   Evi-1   C/EBPalpha   POU2F1   CP2   ARP-1   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIB2 promoter sequence
   Search Chromatin IP Primers for TRIB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24.3   Ensembl cytogenetic band:  2p24.3   HGNC cytogenetic band: 2p25.1

TRIB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIB2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P012856:  view genomic region     (about GC identifiers)

Start:
12,856,998 bp from pter      End:
12,882,860 bp from pter
Size:
25,863 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TRIB2

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TRIB2_HUMAN, Q92519 (See protein sequence)
Recommended Name: Tribbles homolog 2  
Size: 343 amino acids; 38801 Da
Miscellaneous: Antibodies against TRIB2 are present in sera from patients with autoimmune uveitis
Secondary accessions: B2R851 D6W510

Explore the universe of human proteins at neXtProt for TRIB2: NX_Q92519

Explore proteomics data for TRIB2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys20
  • Modification sites at PhosphoSitePlus

  • See TRIB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067675.1  
    ENSEMBL proteins: 
     ENSP00000155926   ENSP00000370874   ENSP00000384260  

    TRIB2 Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for TRIB2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIB2

     
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    antibodies-online proteins for TRIB2 (8 products) 

     
    antibodies-online peptides for TRIB2

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    antibodies-online antibodies for TRIB2 (40 products) 

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    antibodies-online kits for TRIB2 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: tribbles homolog 2 (Drosophila)
    Trbl family

    3 InterPro protein domains:
     IPR024104 Tribbles/Ser_Thr_kinase_40
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q92519

    ProtoNet protein and cluster: Q92519

    UniProtKB/Swiss-Prot: TRIB2_HUMAN, Q92519
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with TRIB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRIB2_HUMAN, Q92519
    Function: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity
    (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166NOT nucleotide binding ISS--
    GO:0004672NOT protein kinase activity ISS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0004860protein kinase inhibitor activity IEA--
    GO:0005524ATP binding ----
         
    Find genes that share ontologies with TRIB2           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for TRIB2:
     Decreased CYP1A1 activity afte  Decreased Hepatitis C virus re  Decreased focal adhesion (FA)   Decreased influenza A/WSN/33 r 
     Decreased substrate adherent c  Increased Salmonella enterica  

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Trib2):
     behavior/neurological  hematopoietic system  immune system  no phenotypic analysis  normal 

    Find genes that share phenotypes with TRIB2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Trib2tm1Lex for TRIB2

       genOway: Develop your customized and physiologically relevant rodent model for TRIB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRIB2:
    hsa-mir-1297 (MIRT007038), hsa-mir-511-5p (MIRT007037), hsa-mir-106b-5p (MIRT044275)

    Block miRNA regulation of human, mouse, rat TRIB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIB2 (see all 65):
    hsa-miR-219-1-3p hsa-miR-193a-3p hsa-let-7d hsa-miR-3616-5p hsa-miR-485-3p hsa-miR-29a hsa-let-7g hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidTRIB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRIB2
    Predesigned siRNA for gene silencing in human, mouse, rat TRIB2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TRIB2 (NM_021643)
    Sino Biological Human cDNA Clone for TRIB2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIB2
    Addgene plasmids for TRIB2 

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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10656) for TRIB2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRIB2_HUMAN, Q92519: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=May associate with
    the cytoskeleton (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    cytoskeleton2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ISS--
    GO:0005856cytoskeleton IEA--

    Find genes that share ontologies with TRIB2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRIB2
    Interactions:

        Search GeneGlobe Interaction Network for TRIB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for TRIB2 (Q925192, 3 ENSP000001559264) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2872241 I2D: score=3 STRING: ENSP00000357292
    CEBPBENSP000003054224STRING: ENSP00000305422
    CEBPDENSP000003861654STRING: ENSP00000386165
    CEBPEENSP000002065134STRING: ENSP00000206513
    CDC25AENSP000003037064STRING: ENSP00000303706
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468NOT protein phosphorylation ISS--
    GO:0006469negative regulation of protein kinase activity NAS12791994
    GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS--
    GO:0043405regulation of MAP kinase activity ISS--
    GO:0045081negative regulation of interleukin-10 biosynthetic process IMP18643775

    Find genes that share ontologies with TRIB2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIB2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRIB2 gene: 
    NM_021643.3  

    Unigene Cluster for TRIB2:

    Tribbles homolog 2 (Drosophila)
    Hs.467751  [show with all ESTs]
    Unigene Representative Sequence: NM_021643
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000155926(uc002rbv.4 uc010yjp.2) ENST00000483034 ENST00000381465
    ENST00000405331
    miRNA
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    Block miRNA regulation of human, mouse, rat TRIB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIB2 (see all 65):
    hsa-miR-219-1-3p hsa-miR-193a-3p hsa-let-7d hsa-miR-3616-5p hsa-miR-485-3p hsa-miR-29a hsa-let-7g hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidTRIB2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TRIB2
    Predesigned siRNA for gene silencing in human, mouse, rat TRIB2
    Clone
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    OriGene ORF clones in mouse, rat for TRIB2
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    GenScript: all cDNA clones in your preferred vector: TRIB2 (NM_021643)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIB2
    Addgene plasmids for TRIB2 
    Primer
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    OriGene qPCR primer pairs and template standards for TRIB2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIB2
      QuantiTect SYBR Green Assays in human, mouse, rat TRIB2
      QuantiFast Probe-based Assays in human, mouse, rat TRIB2
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10656) for TRIB2 

    Additional mRNA sequence: 

    AK129973.1 AK299146.1 AK313237.1 AY245544.1 BC002637.2 D87119.1 NR_027303.1 

    17 DOTS entries:

    DT.450629  DT.100703781  DT.100026118  DT.121031532  DT.121031473  DT.121031529  DT.100802413  DT.92050383 
    DT.40116032  DT.92450466  DT.92450469  DT.100802411  DT.100802407  DT.118857  DT.121031454  DT.100772452 
    DT.121031487 

    Selected AceView cDNA sequences (see all 263):

    CR626569 AU280175 BQ221000 AA437035 AI015721 CR614490 AW408806 AA331494 
    AY245544 AA363914 BU182685 AI984361 BE046502 AI445143 CR591249 AL138166 
    N31166 BM711648 W03028 AA383065 AA459890 AI088956 BG236851 AA386314 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TRIB2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
    SP1:                                      -         
    SP2:              -                                 
    SP3:                                                


    ECgene alternative splicing isoforms for TRIB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGGATCT
    TRIB2 Expression
    About this image


    TRIB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Globus Pallidus
     
     Ovary (Reproductive System)
             Mature follicles
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Peripheral Nervous System (Nervous System)
     
     Spinal Cord (Nervous System)
    TRIB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.467751

    UniProtKB/Swiss-Prot: TRIB2_HUMAN, Q92519
    Tissue specificity: Highly expressed in peripheral blood leukocytes

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRIB2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trib21 , 5 tribbles homolog 2 (Drosophila)1, 5 91.64(n)1
    98.25(a)1
      12 (7.25 cM)5
    2174101  NM_144551.51  NP_653134.21 
     157917275 
    chicken
    (Gallus gallus)
    Aves TRIB21 tribbles homolog 2 (Drosophila) 84.16(n)
    95.63(a)
      378919  NM_204401.2  NP_989732.2 
    lizard
    (Anolis carolinensis)
    Reptilia TRIB26
    tribbles pseudokinase 2
    88(a)
    1 ↔ 1
    1(146227980-146258714)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB109102.12   -- 80.59(n)    AB109102.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trib21 tribbles homolog 2 (Drosophila) 72.22(n)
    78.65(a)
      100331041  XM_002667743.2  XP_002667789.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta trbl1 tribbles 53.45(n)
    43.97(a)
      43999  NM_079933.4  NP_524672.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nipi-36
    Protein NIPI-3 (nipi-3) mRNA, complete cds
    10(a)
    1 → many
    X(15607969-15611811) WBGene00010700


    ENSEMBL Gene Tree for TRIB2 (if available)
    TreeFam Gene Tree for TRIB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIB2 gene
    STK402  TRIB32  NUAK12  PRKAA22  HUNK2  TRIB12  NUAK22  PRKAA12  
    MELK2  
    Selected SIMAP similar genes for TRIB2 using alignment to 3 protein entries:     TRIB2_HUMAN (see all proteins) (see all similar genes):
    TRIB1    MARK4    TRIB3    BRSK2    STK33    CAMK2D
    MAPKAPK3    PLK4    AKT1    CAMK2B    MARK2    AKT2
    NUAK1    RPS6KA3    MARK3    RPS6KA1    RPS6KA2    CHEK2

    Find genes that share paralogs with TRIB2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIB2 (see all 581)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs339779541,2
    C--12727196(+) TGGGT-/AAGAGG 2 -- int10--------
    rs592162731,2
    C,F--12822329(+) CCTGAC/GGTTCA 2 -- us2k11Minor allele frequency- G:0.27WA 118
    rs1446623391,2
    --12822421(+) TTCCCA/GGTCTT 2 -- us2k10--------
    rs1485346881,2
    --12822422(+) TCCCAA/GTCTTT 2 -- us2k10--------
    rs1825544861,2
    --12822475(+) TCTTAC/TTCATA 2 -- us2k10--------
    rs1862819221,2
    --12822822(+) GTGTCC/TTCCTG 2 -- us2k10--------
    rs75938631,2
    C,F,H--12823028(+) AGTCAA/GTGTCC 2 -- us2k19Minor allele frequency- G:0.15NS EA NA WA 1202
    rs1895235311,2
    --12823214(+) CCAGGA/TGTCGT 2 -- us2k10--------
    rs1822716151,2
    --12823268(+) TTTGTC/TCTCTA 2 -- us2k10--------
    rs1853252331,2
    --12823280(+) TAGATA/CGCTTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRIB2 (12856998 - 12882860 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TRIB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873666CNV Loss21882294
    dgv4056n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609462    OMIM disorders: --


    Find genes that share disorders with TRIB2           About GenesLikeMe

    Genetic Association Database (GAD): TRIB2
    Human Genome Epidemiology (HuGE) Navigator: TRIB2 (3 documents)

    Export disorders for TRIB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIB2 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with TRIB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PubMed id 20468071)1, 4 Dick D.M....Bierut L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    2. Tribbles: novel regulators of cell function; evolutionary aspects. (PubMed id 16715410)1, 3 Hegedus Z....Kiss-Toth E. (Cell. Mol. Life Sci. 2006)
    3. Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia. (PubMed id 17097562)1, 3 Keeshan K....Pear W.S. (Cancer Cell 2006)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display. (PubMed id 15950723)1, 2 Zhang Y.... Li W. (Mol. Immunol. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. (PubMed id 15299019)1, 2 Kiss-Toth E.... Dower S.K. (J. Biol. Chem. 2004)
    8. SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription. (PubMed id 12736262)1, 3 Wu M.... Shu H.B. (J. Biol. Chem. 2003)
    9. Human tribbles homologue 2 is expressed in unstable regions of carotid plaques and regulates macrophage IL-10 in vitro. (PubMed id 18643775)1, 9 Deng J....Davis B. (Clin. Sci. 2009)
    10. Survival factor withdrawal-induced apoptosis of TF-1 cells involves a TRB2-Mcl-1 axis-dependent pathway. (PubMed id 17545167)1, 9 Lin K.R....Yen J.J. (J. Biol. Chem. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 28951 HGNC: 30809 AceView: TRIB2 Ensembl:ENSG00000071575 euGenes: HUgn28951
    ECgene: TRIB2 H-InvDB: TRIB2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TRIB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIB2 gene:
    Search GeneIP for patents involving TRIB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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