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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIB2 Gene

protein-coding   GIFtS: 57
GCID: GC02P012856

Tribbles Pseudokinase 2

(Previous name: tribbles homolog 2 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Tribbles Pseudokinase 21     GS39552
Tribbles Homolog 2 (Drosophila)1 2     Tribbles Homolog 22
TRB22 3     TRB-23
C5FW2     

External Ids:    HGNC: 308091   Entrez Gene: 289512   Ensembl: ENSG000000715757   OMIM: 6094625   UniProtKB: Q925193   
ORGUL members:         
NONCODE14:n338680 n407780      

Export aliases for TRIB2 gene to outside databases

Previous GC identifers: GC02P012879 GC02P012807 GC02P012706


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRIB2 Gene:
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is
homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic
function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of
physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the
hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1)
cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding
protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found
for this gene. (provided by RefSeq, Mar 2009)

GeneCards Summary for TRIB2 Gene: 
TRIB2 (tribbles pseudokinase 2) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with TRIB2 include conduct disorder, and narcolepsy. GO annotations related to this gene include protein kinase activity and nucleotide binding. An important paralog of this gene is BRSK1.

UniProtKB/Swiss-Prot: TRIB2_HUMAN, Q92519
Function: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity
(By similarity)

Gene Wiki entry for TRIB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005334.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIB2 gene promoter:
         RP58   Lmo2   Olf-1   AP-4   Evi-1   C/EBPalpha   POU2F1   CP2   ARP-1   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24.3   Ensembl cytogenetic band:  2p24.3   HGNC cytogenetic band: 2p25.1

TRIB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIB2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P012856:  view genomic region     (about GC identifiers)

Start:
12,856,998 bp from pter      End:
12,882,860 bp from pter
Size:
25,863 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TRIB2

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRIB2_HUMAN, Q92519 (See protein sequence)
Recommended Name: Tribbles homolog 2  
Size: 343 amino acids; 38801 Da
Subcellular location: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=May associate with
the cytoskeleton (By similarity)
Miscellaneous: Antibodies against TRIB2 are present in sera from patients with autoimmune uveitis
Secondary accessions: B2R851 D6W510

Explore the universe of human proteins at neXtProt for TRIB2: NX_Q92519

Explore proteomics data for TRIB2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92519

  • TRIB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRIB2 Protein Expression
    REFSEQ proteins: NP_067675.1  
    ENSEMBL proteins: 
     ENSP00000155926   ENSP00000370874   ENSP00000384260  

    Human Recombinant Protein Products for TRIB2: 
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    OriGene Protein Over-expression Lysate for TRIB2
    OriGene MassSpec for TRIB2 
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    Novus Biologicals TRIB2 Proteins
    Novus Biologicals TRIB2 Lysates
    Sino Biological Recombinant Protein for TRIB2
    Sino Biological Cell Lysate for TRIB2 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIB2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ISS--
    GO:0005856cytoskeleton IEA--

    TRIB2 for ontologies           About GeneDecksing



    TRIB2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for TRIB2 

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    Cloud-Clone Corp. ELISAs for TRIB2 
    Cloud-Clone Corp. CLIAs for TRIB2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: tribbles homolog 2 (Drosophila) 
    Trbl family

    3 InterPro protein domains:
     IPR024104 Tribbles/Ser_Thr_kinase_40
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q92519

    ProtoNet protein and cluster: Q92519

    UniProtKB/Swiss-Prot: TRIB2_HUMAN, Q92519
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily
    Similarity: Contains 1 protein kinase domain


    TRIB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRIB2_HUMAN, Q92519
    Function: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity
    (By similarity)

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166NOT nucleotide binding ISS--
    GO:0004672NOT protein kinase activity ISS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0004860protein kinase inhibitor activity IEA--
    GO:0005524ATP binding ----
         
    TRIB2 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for TRIB2:
     Decreased CYP1A1 activity afte  Decreased Hepatitis C virus re  Decreased focal adhesion (FA)   Decreased influenza A/WSN/33 r 
     Decreased substrate adherent c  Increased Salmonella enterica  

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Trib2):
     behavior/neurological  hematopoietic system  immune system  no phenotypic analysis  normal 

    TRIB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Trib2tm1Lex for TRIB2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRIB2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRIB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIB2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIB2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIB2
    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIB2 (see all 65):
    hsa-miR-219-1-3p hsa-miR-193a-3p hsa-let-7d hsa-miR-3616-5p hsa-miR-485-3p hsa-miR-29a hsa-let-7g hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidTRIB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRIB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIB2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TRIB2
    Sirion Biotech Customized adenovirus for overexpression of TRIB2

    Clone
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    OriGene clones in human, mouse for TRIB2 (see all 7)
    OriGene ORF clones in mouse, rat for TRIB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIB2 (NM_021643)
    Sino Biological Human cDNA Clone for TRIB2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIB2
    Sirion Biotech Customized lentivirus for stable overexpression of TRIB2 
                         Customized lentivirus expression plasmids for stable overexpression of TRIB2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TRIB2
    Search LifeMap BioReagents cell lines for TRIB2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIB2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIB2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TRIB2 (Q925192, 3 ENSP000001559264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2872241 I2D: score=3 STRING: ENSP00000357292
    SLAMF7ENSP000003570224STRING: ENSP00000357022
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468NOT protein phosphorylation ISS--
    GO:0006469negative regulation of protein kinase activity NAS12791994
    GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS--
    GO:0043405regulation of MAP kinase activity ISS--
    GO:0045081negative regulation of interleukin-10 biosynthetic process IMP18643775

    TRIB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIB2

    Search CenterWatch for drugs/clinical trials and news about TRIB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRIB2 gene: 
    NM_021643.3  

    Unigene Cluster for TRIB2:

    Tribbles homolog 2 (Drosophila)
    Hs.467751  [show with all ESTs]
    Unigene Representative Sequence: NM_021643
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000155926(uc002rbv.4 uc010yjp.2) ENST00000483034 ENST00000381465
    ENST00000405331
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIB2
    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIB2 (see all 65):
    hsa-miR-219-1-3p hsa-miR-193a-3p hsa-let-7d hsa-miR-3616-5p hsa-miR-485-3p hsa-miR-29a hsa-let-7g hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidTRIB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRIB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIB2
    Clone
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    OriGene clones in human, mouse for TRIB2 (see all 7)
    OriGene ORF clones in mouse, rat for TRIB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIB2 (NM_021643)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIB2
    Sirion Biotech Customized lentivirus for stable overexpression of TRIB2 
                         Customized lentivirus expression plasmids for stable overexpression of TRIB2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRIB2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIB2

    Additional mRNA sequence: 

    AK129973.1 AK299146.1 AK313237.1 AY245544.1 BC002637.2 D87119.1 NR_027303.1 

    17 DOTS entries:

    DT.450629  DT.100703781  DT.100026118  DT.121031532  DT.121031473  DT.121031529  DT.100802413  DT.92050383 
    DT.40116032  DT.92450466  DT.92450469  DT.100802411  DT.100802407  DT.118857  DT.121031454  DT.100772452 
    DT.121031487 

    24/263 AceView cDNA sequences (see all 263):

    AA677975 AI015721 AA331494 AI088956 BQ213118 AW408806 AA437035 AL138166 
    AA459890 BX492938 W03028 BE046502 BQ221000 BM711648 CR591249 BU182685 
    BG055992 N72285 AA383065 N31166 BQ636172 BC002637 AI014458 AA809280 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TRIB2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
    SP1:                                      -         
    SP2:              -                                 
    SP3:                                                


    ECgene alternative splicing isoforms for TRIB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIB2 expression in normal human tissues (normalized intensities)      TRIB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGGATCT
    TRIB2 Expression
    About this image


    TRIB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Globus Pallidus
             Septum   
     
     Spinal Cord (Nervous System)
             Dorsal Horn   
     
     Blood (Hematopoietic System)
             cd4+ t cell   
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Uncategorized (Uncategorized)
             PureStem Progenitor EN13

    See TRIB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIB2

    SOURCE GeneReport for Unigene cluster: Hs.467751

    UniProtKB/Swiss-Prot: TRIB2_HUMAN, Q92519
    Tissue specificity: Highly expressed in peripheral blood leukocytes

        SABiosciences Custom PCR Arrays for TRIB2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TRIB2 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trib21 , 5 tribbles homolog 2 (Drosophila)1, 5 91.64(n)1
    98.25(a)1
      12 (7.25 cM)5
    2174101  NM_144551.51  NP_653134.21 
     157917275 
    chicken
    (Gallus gallus)
    Aves TRIB21 tribbles homolog 2 (Drosophila) 84.16(n)
    95.63(a)
      378919  NM_204401.2  NP_989732.2 
    lizard
    (Anolis carolinensis)
    Reptilia TRIB26
    Uncharacterized protein
    88(a)
    1 ↔ 1
    1(146227980-146258714)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB109102.12   -- 80.59(n)    AB109102.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trib21 tribbles homolog 2 (Drosophila) 71.53(n)
    77.84(a)
      100331041  XM_002667743.1  XP_002667789.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta trbl1 tribbles 53.62(n)
    44.35(a)
      43999  NM_079933.3  NP_524672.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nipi-36
    Protein NIPI-3
    10(a)
    1 → many
    X(15607969-15610631)


    ENSEMBL Gene Tree for TRIB2 (if available)
    TreeFam Gene Tree for TRIB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIB2 gene
    BRSK12  STK402  TRIB32  BRSK22  TRIB12  
    18/24 SIMAP similar genes for TRIB2 using alignment to 3 protein entries:     TRIB2_HUMAN (see all proteins) (see all similar genes):
    TRIB1    MARK4    TRIB3    BRSK2    STK33    CAMK2D
    MAPKAPK3    PLK4    AKT1    CAMK2B    MARK2    AKT2
    NUAK1    RPS6KA3    MARK3    RPS6KA1    RPS6KA2    CHEK2

    TRIB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/581 SNPs in TRIB2 are shown (see all 581)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs339779541,2
    C--12727196(+) TGGGT-/AAGAGG 2 -- int10--------
    rs592162731,2
    C,F--12822329(+) CCTGAC/GGTTCA 2 -- us2k11Minor allele frequency- G:0.27WA 118
    rs1446623391,2
    --12822421(+) TTCCCA/GGTCTT 2 -- us2k10--------
    rs1485346881,2
    --12822422(+) TCCCAA/GTCTTT 2 -- us2k10--------
    rs1825544861,2
    --12822475(+) TCTTAC/TTCATA 2 -- us2k10--------
    rs1862819221,2
    --12822822(+) GTGTCC/TTCCTG 2 -- us2k10--------
    rs75938631,2
    C,F,H--12823028(+) AGTCAA/GTGTCC 2 -- us2k19Minor allele frequency- G:0.15NS EA NA WA 1202
    rs1895235311,2
    --12823214(+) CCAGGA/TGTCGT 2 -- us2k10--------
    rs1822716151,2
    --12823268(+) TTTGTC/TCTCTA 2 -- us2k10--------
    rs1853252331,2
    --12823280(+) TAGATA/CGCTTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRIB2 (12856998 - 12882860 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TRIB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv873666CNV Loss21882294
    dgv4056n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609462    OMIM disorders: --

    8 diseases for TRIB2:    About MalaCards
    conduct disorder    narcolepsy    hypertriglyceridemia    uveitis
    leukemia    lung cancer    thyroiditis    melanoma


    TRIB2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRIB2
    Human Genome Epidemiology (HuGE) Navigator: TRIB2 (3 documents)

    Export disorders for TRIB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIB2 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with TRIB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evidence for genes on chromosome 2 contributing to al cohol dependence with conduct disorder and suicide attempts. (PubMed id 20468071)1, 4 Dick D.M....Bierut L. (2010)
    2. Tribbles: novel regulators of cell function; evolutio nary aspects. (PubMed id 16715410)1, 3 Hegedus Z....Kiss-Toth E. (2006)
    3. Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia. (PubMed id 17097562)1, 3 Keeshan K....Pear W.S. (2006)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display. (PubMed id 15950723)1, 2 Zhang Y.... Li W. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. (PubMed id 15299019)1, 2 Kiss-Toth E.... Dower S.K. (2004)
    8. SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription. (PubMed id 12736262)1, 3 Wu M.... Shu H.B. (2003)
    9. Human tribbles homologue 2 is expressed in unstable regions of carotid plaques and regulates macrophage IL-10 in vitro. (PubMed id 18643775)1, 9 Deng J....Davis B. (2009)
    10. Survival factor withdrawal-induced apoptosis of TF-1 cells involves a TRB2-Mcl-1 axis-dependent pathway. (PubMed id 17545167)1, 9 Lin K.R....Yen J.J. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28951 HGNC: 30809 AceView: TRIB2 Ensembl:ENSG00000071575 euGenes: HUgn28951
    ECgene: TRIB2 H-InvDB: TRIB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRIB2 gene:
    Search GeneIP for patents involving TRIB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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