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TRIB1 Gene

protein-coding   GIFtS: 55
GCID: GC08P126442

Tribbles Pseudokinase 1

(Previous name: tribbles homolog 1 (Drosophila))
  See TRIB1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tribbles Pseudokinase 11 2     G-Protein-Coupled Receptor-Induced Gene 2 Protein2 3
C8FW2 3 5     Tribbles Homolog 1 (Drosophila)1
SKIP12 3 5     G-Protein-Coupled Receptor Induced Protein2
TRB12 3 5     G-Protein-Coupled Receptor-Induced Protein 22
GIG-22 3     Phosphoprotein Regulated By Mitogenic Pathways2
GIG22 3     Tribbles Homolog 12
TRB-12 3     Tribbles-Like Protein 12

External Ids:    HGNC: 168911   Entrez Gene: 102212   Ensembl: ENSG000001733347   OMIM: 6094615   UniProtKB: Q96RU83   

Export aliases for TRIB1 gene to outside databases

Previous GC identifers: GC08P126400 GC08P126511 GC08P121766


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRIB1 Gene:
TRIB1 (tribbles pseudokinase 1) is a protein-coding gene. Diseases associated with TRIB1 include megakaryocytic leukemia, and familial hypercholesterolemia. GO annotations related to this gene include transcription factor binding and ubiquitin protein ligase binding. An important paralog of this gene is STK40.

UniProtKB/Swiss-Prot: TRIB1_HUMAN, Q96RU8
Function: Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity

Gene Wiki entry for TRIB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIB1 gene promoter:
         ER-alpha   C/EBPbeta   p53   SREBP-1c   LCR-F1   Egr-4   SREBP-1b   c-Ets-1   SREBP-1a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIB1 promoter sequence
   Search Chromatin IP Primers for TRIB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.13   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24.13

TRIB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIB1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P126442:  view genomic region     (about GC identifiers)

Start:
126,442,563 bp from pter      End:
126,450,647 bp from pter
Size:
8,085 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRIB1_HUMAN, Q96RU8 (See protein sequence)
Recommended Name: Tribbles homolog 1  
Size: 372 amino acids; 41009 Da
Secondary accessions: C5HU08 O15180 Q9H2Y8

Explore the universe of human proteins at neXtProt for TRIB1: NX_Q96RU8

Explore proteomics data for TRIB1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRIB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001269914.1  NP_079471.1  

    ENSEMBL proteins: 
     ENSP00000312150   ENSP00000429063   ENSP00000428879  

    TRIB1 Human Recombinant Protein Products:

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    OriGene Purified Protein for TRIB1
    OriGene Protein Over-expression Lysate for TRIB1
    OriGene MassSpec for TRIB1
    OriGene Custom Protein Services for TRIB1
    GenScript Custom Purified and Recombinant Proteins Services for TRIB1
    Novus Biologicals TRIB1 Protein
    Novus Biologicals TRIB1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIB1

     
    Search eBioscience for Proteins for TRIB1 

    TRIB1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TRIB1
    Browse R&D Systems for Antibodies
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    Novus Biologicals TRIB1 Antibodies
    Abcam antibodies for TRIB1
    Cloud-Clone Corp. Antibodies for TRIB1
    ThermoFisher Antibodies for TRIB1
    LSBio Antibodies in human, mouse, rat for TRIB1

    TRIB1 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRIB1
    Cloud-Clone Corp. CLIAs for TRIB1
    Search eBioscience for ELISAs for TRIB1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: tribbles homolog 1 (Drosophila)
    Trbl family

    4 InterPro protein domains:
     IPR024105 Tribbles_TRB1
     IPR024104 Tribbles/Ser_Thr_kinase_40
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q96RU8

    ProtoNet protein and cluster: Q96RU8

    UniProtKB/Swiss-Prot: TRIB1_HUMAN, Q96RU8
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with TRIB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRIB1_HUMAN, Q96RU8
    Function: Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672NOT protein kinase activity TAS--
    GO:0004860protein kinase inhibitor activity IMP15299019
    GO:0005524NOT ATP binding TAS--
    GO:0008134transcription factor binding IPI17724128
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    Find genes that share ontologies with TRIB1           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Trib1):
     adipose tissue  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system 

    Find genes that share phenotypes with TRIB1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Trib1tm1Aki for TRIB1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIB1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRIB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIB1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRIB1:
    hsa-mir-98-5p (MIRT027499), hsa-mir-99a-5p (MIRT027398), hsa-mir-335-5p (MIRT016950), hsa-mir-26b-5p (MIRT028892), hsa-mir-122-5p (MIRT003109)

    Block miRNA regulation of human, mouse, rat TRIB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIB1 (see all 37):
    hsa-miR-3194-5p hsa-let-7d hsa-miR-548k hsa-miR-548m hsa-let-7g hsa-miR-1244 hsa-let-7a hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidTRIB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRIB1
    Predesigned siRNA for gene silencing in human, mouse, rat TRIB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRIB1

    Clone
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    OriGene clones in human, mouse for TRIB1 (see all 6)
    OriGene ORF clones in mouse, rat for TRIB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIB1 (NM_025195)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIB1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TRIB1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRIB1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    mitochondrion3
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17452330
    GO:0005737cytoplasm IDA17452330

    Find genes that share ontologies with TRIB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRIB1
    Interactions:

        Search GeneGlobe Interaction Network for TRIB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRIB1 (Q96RU83 ENSP000003121504) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP2K7O147333, ENSP000003810664I2D: score=1 STRING: ENSP00000381066
    ALOX12P180543, ENSP000002515354I2D: score=5 STRING: ENSP00000251535
    MAP2K1Q027503, ENSP000003024864I2D: score=3 STRING: ENSP00000302486
    MAP2K4P459853, ENSP000002624454I2D: score=3 STRING: ENSP00000262445
    PTGFRNENSP000003768994STRING: ENSP00000376899
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468NOT protein phosphorylation TAS--
    GO:0006469negative regulation of protein kinase activity IMP15299019
    GO:0007254JNK cascade IMP17452330
    GO:0014912negative regulation of smooth muscle cell migration IMP17452330
    GO:0031665negative regulation of lipopolysaccharide-mediated signaling pathway IMP17452330

    Find genes that share ontologies with TRIB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIB1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRIB1 gene (2 alternative transcripts): 
    NM_001282985.1  NM_025195.3  

    Unigene Cluster for TRIB1:

    Tribbles homolog 1 (Drosophila)
    Hs.444947  [show with all ESTs]
    Unigene Representative Sequence: NM_025195
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311922(uc003yrx.3 uc011lis.2 uc010mdn.3) ENST00000520847
    ENST00000521778 ENST00000519576
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRIB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIB1 (see all 37):
    hsa-miR-3194-5p hsa-let-7d hsa-miR-548k hsa-miR-548m hsa-let-7g hsa-miR-1244 hsa-let-7a hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidTRIB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRIB1
    Predesigned siRNA for gene silencing in human, mouse, rat TRIB1
    Clone
    Products:
         
    OriGene clones in human, mouse for TRIB1 (see all 6)
    OriGene ORF clones in mouse, rat for TRIB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIB1 (NM_025195)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIB1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRIB1
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIB1
      QuantiTect SYBR Green Assays in human, mouse, rat TRIB1
      QuantiFast Probe-based Assays in human, mouse, rat TRIB1

    Additional mRNA sequence: 

    AF205437.1 AF250310.1 AJ000480.1 AK001319.1 AK022787.1 AK297539.1 AK307561.1 AL832388.1 
    BC012441.1 BC063292.1 

    9 DOTS entries:

    DT.451897  DT.121472678  DT.92435383  DT.40118059  DT.100673814  DT.75138602  DT.121472668  DT.95170987 
    DT.95352562 

    Selected AceView cDNA sequences (see all 229):

    AI868604 BM718995 AA845416 AI681167 BU626402 CR608019 AI636958 BE550935 
    AI766962 AI298527 AL556120 AI989599 Z41574 AI362767 AI825569 BM771284 
    AW263066 AL832388 AU125722 AI982592 AA977019 BU743267 CA423009 AI373497 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TRIB1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c
    SP1:        -     -                       -                     
    SP2:              -                       -                     
    SP3:                                                            
    SP4:                                                            


    ECgene alternative splicing isoforms for TRIB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACTTTGAG
    TRIB1 Expression
    About this image


    TRIB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
     
     Ovary (Reproductive System)
             Mature Granulosa Cells Antral Follicle
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
     
     Thyroid (Endocrine System)
    TRIB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444947

    UniProtKB/Swiss-Prot: TRIB1_HUMAN, Q96RU8
    Tissue specificity: Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland,
    pancreas, peripheral blood leukocytes, and bone marrow

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    QuantiFast Probe-based Assays in human, mouse, rat TRIB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRIB1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trib11 , 5 tribbles homolog 1 (Drosophila)1, 5 88.35(n)1
    93.82(a)1
      15 (25.41 cM)5
    2117701  NM_144549.41  NP_653132.11 
     596483505 
    chicken
    (Gallus gallus)
    Aves LOC4283861 tribbles homolog 1-like 80.9(n)
    91.3(a)
      428386  XM_425946.4  XP_425946.4 
    lizard
    (Anolis carolinensis)
    Reptilia TRIB16
    tribbles pseudokinase 1
    79(a)
    1 ↔ 1
    4(5473344-5488432)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia trib11 tribbles homolog 1 (Drosophila) 73.17(n)
    75.53(a)
      100497021  XM_002938661.2  XP_002938707.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trib16
    tribbles homolog 1 (Drosophila)
    51(a)
    1 ↔ 1
    19(34574921-34576211) ENSDARG00000076142
    fruit fly
    (Drosophila melanogaster)
    Insecta trbl6
    tribbles
    25(a)
    1 → many
    3L(20389388-20394709)
    worm
    (Caenorhabditis elegans)
    Secernentea nipi-36
    Protein NIPI-3 (nipi-3) mRNA, complete cds
    12(a)
    1 → many
    X(15607969-15611811) WBGene00010700


    ENSEMBL Gene Tree for TRIB1 (if available)
    TreeFam Gene Tree for TRIB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIB1 gene
    STK402  TRIB32  NUAK12  PRKAA22  HUNK2  NUAK22  PRKAA12  TRIB22  
    MELK2  
    Selected SIMAP similar genes for TRIB1 using alignment to 3 protein entries:     TRIB1_HUMAN (see all proteins) (see all similar genes):
    TRIB2    TRIB3    MARK4    PKN2    NUAK1    BRSK2
    CAMK2D    OBSCN    CAMK2B    CAMK2G    CAMKK1    MAP3K4
    AKT2    CASK    MAPKAPK3    MAPKAPK5    TSSK6    AURKB

    Find genes that share paralogs with TRIB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIB1 (see all 280)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0423704
    A lung large cell carcinoma sample4--see VAR_0423702 F L mis40--------
    rs1462812921,2
    --126440563(+) TTAACC/GGCAGC 1 -- us2k10--------
    rs1126067871,2
    C--126440589(+) CGTTCT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs726473191,2
    C,F--126440596(+) TTTTT-/A/TAAATT 1 -- us2k11NS 364
    rs1821874251,2
    --126440596(+) TTTTTA/TAAATT 1 -- us2k10--------
    rs726473201,2
    F--126440599(+) TTAAA-/ATTATT 1 -- us2k11Minor allele frequency- A:0.03NS 364
    rs1872637691,2
    --126440617(+) TTATTA/TTTTAT 1 -- us2k10--------
    rs726473211,2
    C,F--126440730(+) TCAGCC/TTCCCC 1 -- us2k11Minor allele frequency- T:0.01NS 358
    rs726473221,2
    C,F--126440799(+) ACGGGG/-TTTCA 1 -- us2k11Minor allele frequency- -:0.07NS 364
    rs726473231,2
    C,F--126440867(+) AGCCTC/TCCAAA 1 -- us2k11Minor allele frequency- T:0.01NS 364

    HapMap Linkage Disequilibrium report for TRIB1 (126442563 - 126450647 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TRIB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2737545CNV Deletion23290073
    nsv509276CNV Insertion20534489
    esv1002169CNV Loss20482838

    Human Gene Mutation Database (HGMD): TRIB1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIB1
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609461    OMIM disorders: --

    2 diseases for TRIB1:    
    About MalaCards
    megakaryocytic leukemia    familial hypercholesterolemia


    Find genes that share disorders with TRIB1           About GenesLikeMe

    Genetic Association Database (GAD): TRIB1
    Human Genome Epidemiology (HuGE) Navigator: TRIB1 (22 documents)

    Export disorders for TRIB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIB1 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with TRIB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells. (PubMed id 9342215)1, 2, 3 Wilkin F.... Maenhaut C. (Eur. J. Biochem. 1997)
    2. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PubMed id 22479202)1, 4 Dastani Z....Kathiresan S. (PLoS Genet. 2012)
    3. A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. (PubMed id 21386085)1, 4 Kraja A.T....Borecki I.B. (Diabetes 2011)
    4. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PubMed id 22001757)1, 4 Chambers J.C....Kooner J.S. (Nat. Genet. 2011)
    5. TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population. (PubMed id 21071687)1, 4 Varbo A....TybjA ( 2011)
    6. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. (PubMed id 20864672)1, 4 Waterworth D.M....Sandhu M.S. (Arterioscler. Thromb. Vasc. Biol. 2010)
    7. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)1, 4 Fontaine-Bisson B....Franks P.W. (Diabetologia 2010)
    8. Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients. (PubMed id 19760754)1, 4 TAPrkvist L....Pettersson S. (Inflamm. Bowel Dis. 2010)
    9. Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study. (PubMed id 20570916)1, 4 Keebler M.E....Kathiresan S. (Circ Cardiovasc Genet 2010)
    10. Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples. (PubMed id 20160193)1, 4 Weissglas-Volkov D....Pajukanta P. (Circ Cardiovasc Genet 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10221 HGNC: 16891 AceView: TRIB1 Ensembl:ENSG00000173334 euGenes: HUgn10221
    ECgene: TRIB1 H-InvDB: TRIB1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TRIB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TRIB1 gene:
    Search GeneIP for patents involving TRIB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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