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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIB1 Gene

protein-coding   GIFtS: 56
GCID: GC08P126442

Tribbles Pseudokinase 1

(Previous name: tribbles homolog 1 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tribbles Pseudokinase 11     TRB12 3
Tribbles Homolog 1 (Drosophila)1 2     G-Protein-Coupled Receptor-Induced Gene 2 Protein2 3
C8FW2 3     G-Protein-Coupled Receptor Induced Protein2
GIG-22 3     G-Protein-Coupled Receptor-Induced Protein 22
GIG22 3     Phosphoprotein Regulated By Mitogenic Pathways2
SKIP12 3     Tribbles Homolog 12
TRB-12 3     Tribbles-Like Protein 12

External Ids:    HGNC: 168911   Entrez Gene: 102212   Ensembl: ENSG000001733347   OMIM: 6094615   UniProtKB: Q96RU83   

Export aliases for TRIB1 gene to outside databases

Previous GC identifers: GC08P126400 GC08P126511 GC08P121766


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TRIB1 Gene: 
TRIB1 (tribbles pseudokinase 1) is a protein-coding gene. Diseases associated with TRIB1 include ischemic heart disease, and familial hypercholesterolemia. GO annotations related to this gene include transcription factor binding and ubiquitin protein ligase binding. An important paralog of this gene is BRSK1.

UniProtKB/Swiss-Prot: TRIB1_HUMAN, Q96RU8
Function: Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity

Gene Wiki entry for TRIB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIB1 gene promoter:
         ER-alpha   C/EBPbeta   p53   SREBP-1c   LCR-F1   Egr-4   SREBP-1b   c-Ets-1   SREBP-1a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.13   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24.13

TRIB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIB1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P126442:  view genomic region     (about GC identifiers)

Start:
126,442,563 bp from pter      End:
126,450,647 bp from pter
Size:
8,085 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRIB1_HUMAN, Q96RU8 (See protein sequence)
Recommended Name: Tribbles homolog 1  
Size: 372 amino acids; 41009 Da
Secondary accessions: C5HU08 O15180 Q9H2Y8

Explore the universe of human proteins at neXtProt for TRIB1: NX_Q96RU8

Explore proteomics data for TRIB1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96RU8

  • TRIB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRIB1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001269914.1  NP_079471.1  

    ENSEMBL proteins: 
     ENSP00000312150   ENSP00000429063   ENSP00000428879  

    Human Recombinant Protein Products for TRIB1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for TRIB1
    OriGene MassSpec for TRIB1 
    OriGene Custom Protein Services for TRIB1
    GenScript Custom Purified and Recombinant Proteins Services for TRIB1
    Novus Biologicals TRIB1 Protein
    Novus Biologicals TRIB1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIB1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17452330
    GO:0005737cytoplasm IDA17452330

    TRIB1 for ontologies           About GeneDecksing



    TRIB1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TRIB1
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    LSBio Antibodies in human, mouse, rat for TRIB1 

    Assay Products for TRIB1: 
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    Cloud-Clone Corp. ELISAs for TRIB1 
    Cloud-Clone Corp. CLIAs for TRIB1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: tribbles homolog 1 (Drosophila) 
    Trbl family

    4 InterPro protein domains:
     IPR024105 Tribbles_TRB1
     IPR024104 Tribbles/Ser_Thr_kinase_40
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q96RU8

    ProtoNet protein and cluster: Q96RU8

    UniProtKB/Swiss-Prot: TRIB1_HUMAN, Q96RU8
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily
    Similarity: Contains 1 protein kinase domain


    TRIB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRIB1_HUMAN, Q96RU8
    Function: Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672NOT protein kinase activity TAS--
    GO:0004860protein kinase inhibitor activity IMP15299019
    GO:0005524NOT ATP binding TAS--
    GO:0008134transcription factor binding IPI17724128
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    TRIB1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Trib1):
     growth/size  immune system 

    TRIB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Trib1tm1Aki for TRIB1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRIB1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRIB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIB1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIB1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRIB1:
    hsa-mir-122 (MIRT003109)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIB1
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIB1 (see all 37):
    hsa-miR-3194-5p hsa-let-7d hsa-miR-548k hsa-miR-548m hsa-let-7g hsa-miR-1244 hsa-let-7a hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidTRIB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRIB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRIB1
    Sirion Biotech Customized adenovirus for overexpression of TRIB1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TRIB1 (see all 7)
    OriGene ORF clones in mouse, rat for TRIB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIB1 (NM_025195)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIB1
    Sirion Biotech Customized lentivirus for stable overexpression of TRIB1 
                         Customized lentivirus expression plasmids for stable overexpression of TRIB1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TRIB1
    Search LifeMap BioReagents cell lines for TRIB1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIB1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/23 Interacting proteins for TRIB1 (Q96RU83 ENSP000003121504) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP2K7O147333, ENSP000003810664I2D: score=1 STRING: ENSP00000381066
    ALOX12P180543, ENSP000002515354I2D: score=5 STRING: ENSP00000251535
    MAP2K1Q027503, ENSP000003024864I2D: score=3 STRING: ENSP00000302486
    MAP2K4P459853, ENSP000002624454I2D: score=3 STRING: ENSP00000262445
    PTGFRNENSP000003768994STRING: ENSP00000376899
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468NOT protein phosphorylation TAS--
    GO:0006469negative regulation of protein kinase activity IMP15299019
    GO:0007254JNK cascade IMP17452330
    GO:0014912negative regulation of smooth muscle cell migration IMP17452330
    GO:0031665negative regulation of lipopolysaccharide-mediated signaling pathway IMP17452330

    TRIB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIB1

    Search CenterWatch for drugs/clinical trials and news about TRIB1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRIB1 gene (2 alternative transcripts): 
    NM_001282985.1  NM_025195.3  

    Unigene Cluster for TRIB1:

    Tribbles homolog 1 (Drosophila)
    Hs.444947  [show with all ESTs]
    Unigene Representative Sequence: NM_025195
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311922(uc003yrx.3 uc011lis.2 uc010mdn.3) ENST00000520847
    ENST00000521778 ENST00000519576
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIB1
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIB1 (see all 37):
    hsa-miR-3194-5p hsa-let-7d hsa-miR-548k hsa-miR-548m hsa-let-7g hsa-miR-1244 hsa-let-7a hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidTRIB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRIB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIB1
    Clone
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    OriGene clones in human, mouse for TRIB1 (see all 7)
    OriGene ORF clones in mouse, rat for TRIB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIB1 (NM_025195)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIB1
    Sirion Biotech Customized lentivirus for stable overexpression of TRIB1 
                         Customized lentivirus expression plasmids for stable overexpression of TRIB1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRIB1
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIB1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIB1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIB1

    Additional mRNA sequence: 

    AF205437.1 AF250310.1 AJ000480.1 AK001319.1 AK022787.1 AK297539.1 AK307561.1 AL832388.1 
    BC012441.1 BC063292.1 

    9 DOTS entries:

    DT.451897  DT.121472678  DT.92435383  DT.40118059  DT.100673814  DT.75138602  DT.121472668  DT.95170987 
    DT.95352562 

    24/229 AceView cDNA sequences (see all 229):

    BU626402 AA234073 CA431969 AA573225 AW590300 BF224393 AI636958 BU161806 
    BM760712 AI399784 BM845659 BM771284 BF001703 BM739232 AI982592 BM718995 
    BC012441 NM_025195 BE222447 AI492079 AI362767 AW263066 CB131734 BM682979 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TRIB1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c
    SP1:        -     -                       -                     
    SP2:              -                       -                     
    SP3:                                                            
    SP4:                                                            


    ECgene alternative splicing isoforms for TRIB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIB1 expression in normal human tissues (normalized intensities)      TRIB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACTTTGAG
    TRIB1 Expression
    About this image


    TRIB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Conventional Dendritic Cells I Spleen
             neutrophils   
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Intestine (Gastrointestinal Tract)
             ileum   
     
     Ovary (Reproductive System)
             Mature Granulosa Cells Antral Follicle
     
     Breast (Uncategorized)
             breast stroma   

    See TRIB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIB1

    SOURCE GeneReport for Unigene cluster: Hs.444947

    UniProtKB/Swiss-Prot: TRIB1_HUMAN, Q96RU8
    Tissue specificity: Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland,
    pancreas, peripheral blood leukocytes, and bone marrow

        SABiosciences Custom PCR Arrays for TRIB1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TRIB1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trib11 , 5 tribbles homolog 1 (Drosophila)1, 5 88.35(n)1
    93.82(a)1
      15 (25.41 cM)5
    2117701  NM_144549.41  NP_653132.11 
     596483505 
    chicken
    (Gallus gallus)
    Aves LOC4283861 tribbles homolog 1-like 80.76(n)
    91.3(a)
      428386  XM_425946.3  XP_425946.3 
    lizard
    (Anolis carolinensis)
    Reptilia TRIB16
    tribbles homolog 1 (Drosophila)
    79(a)
    1 ↔ 1
    4(5473344-5488432)
    zebrafish
    (Danio rerio)
    Actinopterygii trib16
    tribbles homolog 1 (Drosophila)
    43(a)
    1 ↔ 1
    19(34574921-34576211)
    fruit fly
    (Drosophila melanogaster)
    Insecta trbl6
    tribbles
    24(a)
    1 → many
    3L(20389388-20394709)
    worm
    (Caenorhabditis elegans)
    Secernentea nipi-36
    Protein NIPI-3
    11(a)
    1 → many
    X(15607969-15610631)


    ENSEMBL Gene Tree for TRIB1 (if available)
    TreeFam Gene Tree for TRIB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIB1 gene
    BRSK12  STK402  TRIB32  TRIB22  BRSK22  
    18/38 SIMAP similar genes for TRIB1 using alignment to 3 protein entries:     TRIB1_HUMAN (see all proteins) (see all similar genes):
    TRIB2    TRIB3    MARK4    PKN2    NUAK1    BRSK2
    CAMK2D    OBSCN    CAMK2B    CAMK2G    CAMKK1    MAP3K4
    AKT2    CASK    MAPKAPK3    MAPKAPK5    TSSK6    AURKB

    TRIB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/280 SNPs in TRIB1 are shown (see all 280)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0423704
    A lung large cell carcinoma sample4--see VAR_0423702 F L mis40--------
    rs1462812921,2
    --126440563(+) TTAACC/GGCAGC 1 -- us2k10--------
    rs1126067871,2
    C--126440589(+) CGTTCT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs726473191,2
    C,F--126440596(+) TTTTT-/A/TAAATT 1 -- us2k11NS 364
    rs1821874251,2
    --126440596(+) TTTTTA/TAAATT 1 -- us2k10--------
    rs726473201,2
    F--126440599(+) TTAAA-/ATTATT 1 -- us2k11Minor allele frequency- A:0.03NS 364
    rs1872637691,2
    --126440617(+) TTATTA/TTTTAT 1 -- us2k10--------
    rs726473211,2
    C,F--126440730(+) TCAGCC/TTCCCC 1 -- us2k11Minor allele frequency- T:0.01NS 358
    rs726473221,2
    C,F--126440799(+) ACGGGG/-TTTCA 1 -- us2k11Minor allele frequency- -:0.07NS 364
    rs726473231,2
    C,F--126440867(+) AGCCTC/TCCAAA 1 -- us2k11Minor allele frequency- T:0.01NS 364

    HapMap Linkage Disequilibrium report for TRIB1 (126442563 - 126450647 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TRIB1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2737545CNV Deletion23290073
    nsv509276CNV Insertion20534489
    esv1002169CNV Loss20482838


    Human Gene Mutation Database (HGMD): TRIB1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609461    OMIM disorders: --

    9 diseases for TRIB1:    About MalaCards
    ischemic heart disease    familial hypercholesterolemia    megakaryocytic leukemia    hypercholesterolemia
    hypertriglyceridemia    coronary heart disease    crohn's disease    thyroiditis
    leukemia


    TRIB1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRIB1
    Human Genome Epidemiology (HuGE) Navigator: TRIB1 (22 documents)

    Export disorders for TRIB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIB1 gene, integrated from 9 sources (see all 64):
    (articles sorted by number of sources associating them with TRIB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells. (PubMed id 9342215)1, 2, 3 Wilkin F.... Maenhaut C. (1997)
    2. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PubMed id 22479202)1, 4 Dastani Z....Kathiresan S. (2012)
    3. A bivariate genome-wide approach to metabolic syndrom e: STAMPEED consortium. (PubMed id 21386085)1, 4 Kraja A.T....Borecki I.B. (2011)
    4. Genome-wide association study identifies loci influenc ing concentrations of liver enzymes in plasma. (PubMed id 22001757)1, 4 Chambers J.C....Kooner J.S. (2011)
    5. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. (PubMed id 20864672)1, 4 Waterworth D.M....Sandhu M.S. (2010)
    6. Evaluating the discriminative power of multi-trait ge netic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)1, 4 Fontaine-Bisson B....Franks P.W. (2010)
    7. Analysis of 39 Crohn's disease risk loci in Swedish i nflammatory bowel disease patients. (PubMed id 19760754)1, 4 TAPrkvist L....Pettersson S. (2010)
    8. Fine-mapping in African Americans of 8 recently disco vered genetic loci for plasma lipids: the Jackson Heart Study. (PubMed id 20570916)1, 4 Keebler M.E....Kathiresan S. (2010)
    9. TRIB1 and GCKR Polymorphisms, Lipid Levels, and Risk of Ischemic Heart Disease in the General Population. (PubMed id 21071687)1, 4 Varbo A....TybjA (2010)
    10. Investigation of variants identified in caucasian gen ome-wide association studies for plasma high-density lipoprotein cholesterol an d triglycerides levels in Mexican dyslipidemic study samples. (PubMed id 20160193)1, 4 Weissglas-Volkov D....Pajukanta P. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10221 HGNC: 16891 AceView: TRIB1 Ensembl:ENSG00000173334 euGenes: HUgn10221
    ECgene: TRIB1 H-InvDB: TRIB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRIB1 gene:
    Search GeneIP for patents involving TRIB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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