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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIB1 Gene

protein-coding   GIFtS: 54
GCID: GC08P126442

tribbles homolog 1 (Drosophila)
 Explore 8 diseases affiliated with
TRIB1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRIB1    

Aliases
for TRIB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tribbles Homolog 1 (Drosophila)1 2     G-Protein-Coupled Receptor-Induced Gene 2 Protein2 3
C8FW1 2 3     G-Protein-Coupled Receptor Induced Protein2
GIG21 2 3     G-Protein-Coupled Receptor-Induced Protein 22
TRB11 2 3     Phosphoprotein Regulated By Mitogenic Pathways2
GIG-22 3     Tribbles Homolog 12
SKIP12 3     Tribbles-Like Protein 12
TRB-12 3     

External Ids:    HGNC: 168911   Entrez Gene: 102212   Ensembl: ENSG000001733347   OMIM: 6094615   UniProtKB: Q96RU83   

Export aliases for TRIB1 gene to outside databases

Previous GC identifers: GC08P126400 GC08P126511 GC08P121766


Summaries
for TRIB1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TRIB1_HUMAN, Q96RU8
Function: Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity

Gene Wiki entry for TRIB1


Genomic Views
for TRIB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIB1 gene promoter:
         ER-alpha   C/EBPbeta   p53   SREBP-1c   LCR-F1   Egr-4   SREBP-1b   c-Ets-1   SREBP-1a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRIB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.13   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24.13

TRIB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIB1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P126442:  view genomic region     (about GC identifiers)

Start:
 126,442,563 bp from pter      End:
 126,450,647 bp from pter
Size:
 8,085 bases      Orientation:
 plus strand

Proteins
for TRIB1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TRIB1_HUMAN, Q96RU8 (See protein sequence)
Recommended Name: Tribbles homolog 1  
Size: 372 amino acids; 41009 Da
Secondary accessions: C5HU08 O15180 Q9H2Y8

Explore the universe of human proteins at neXtProt for TRIB1: NX_Q96RU8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96RU8

    • TRIB1 Protein expression data from MOPED and PaxDb:    About this image 
    TRIB1 Protein Expression
    REFSEQ proteins: NP_079471.1  
    ENSEMBL proteins: 
     ENSP00000312150   ENSP00000429063   ENSP00000428879  

    Human Recombinant Protein Products for TRIB1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: TRIB1
    OriGene Protein Over-expression Lysate: TRIB1
    OriGene Custom Protein Services for TRIB1 
    GenScript Custom Purified and Recombinant Proteins Services for TRIB1
    Novus Biologicals TRIB1 Protein
    Novus Biologicals TRIB1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TRIB1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17452330
    GO:0005737cytoplasm IDA17452330

    TRIB1 for ontologies           About GeneDecksing



    TRIB1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TRIB1
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    Novus Biologicals TRIB1 Antibodies
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    Uscn Antibodies for TRIB1
    ThermoFisher Antibodies for TRIB1

    Assay Products for TRIB1: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for TRIB1

    Protein Domains /
    Families
    for TRIB1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRIB1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR024105 Tribbles_TRB1
     IPR024104 Tribbles/Ser_Thr_kinase_40
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q96RU8

    ProtoNet protein and cluster: Q96RU8

    UniProtKB/Swiss-Prot: TRIB1_HUMAN, Q96RU8
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for TRIB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRIB1_HUMAN, Q96RU8
    Function: Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672NOT protein kinase activity TAS--
    GO:0004860protein kinase inhibitor activity IMP15299019
    GO:0005524NOT ATP binding TAS--
    GO:0008134transcription factor binding IPI17724128
    GO:0031434mitogen-activated protein kinase kinase binding IDA15299019
         
    TRIB1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Trib1):
     growth/size  immune system 

    TRIB1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Trib1tm1Aki for TRIB1
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TRIB1 

    miRNA
    Products:            		miRTarBase miRNAs that target TRIB1:
    hsa-mir-122 (MIRT003109)

    OriGene 3'-UTR Clone: TRIB1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIB1
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIB1 (see all 37):
    hsa-miR-3194-5p hsa-let-7d hsa-miR-548k hsa-miR-548m hsa-let-7g hsa-miR-1244 hsa-let-7a hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmid: TRIB1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIB1 (see all 7)
    OriGene shRNA RFP: TRIB1
    OriGene siRNA: TRIB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIB1
    Sirion Biotech Custom design and validation of potent shRNA sequences against TRIB1 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TRIB1
    Sirion Biotech Customized adenovirus for overexpression of TRIB1 
    Sirion Biotech Customized adenovirus for potent knockdown of TRIB1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIB1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TRIB1 (NM_025195)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIB1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TRIB1
    Search LifeMap BioReagents cell lines for TRIB1
    Sirion Biotech Customized stable knockdown cell line services for TRIB1 
    Sirion Biotech Customized inducible knockdown cell line services for TRIB1
    Sirion Biotech Customized stable overexpressing cell line services for TRIB1
    Sirion Biotech Customized inducible overexpressing cell line services for TRIB1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIB1


    Pathways & Interactions
    for TRIB1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/23 Interacting proteins for TRIB1 (Q96RU83 ENSP000003121504) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP2K7O147333, ENSP000003810664I2D: score=1 STRING: ENSP00000381066
    ALOX12P180543, ENSP000002515354I2D: score=5 STRING: ENSP00000251535
    MAP2K1Q027503, ENSP000003024864I2D: score=3 STRING: ENSP00000302486
    MAP2K4P459853, ENSP000002624454I2D: score=3 STRING: ENSP00000262445
    PTGFRNENSP000003768994STRING: ENSP00000376899
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468NOT protein phosphorylation TAS--
    GO:0006469negative regulation of protein kinase activity IMP15299019
    GO:0007254JNK cascade IMP17452330
    GO:0014912negative regulation of smooth muscle cell migration IMP17452330
    GO:0031665negative regulation of lipopolysaccharide-mediated signaling pathway IMP17452330

    TRIB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRIB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIB1
    Search CenterWatch for drugs/clinical trials and news about TRIB1 

    Transcripts
    for TRIB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRIB1 gene: 
    NM_025195.2  

    Unigene Cluster for TRIB1:

    Tribbles homolog 1 (Drosophila)
    Hs.444947  [show with all ESTs]
    Unigene Representative Sequence: NM_025195
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311922(uc003yrx.3 uc011lis.2 uc010mdn.3) ENST00000520847
    ENST00000521778 ENST00000519576

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TRIB1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIB1
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIB1 (see all 37):
    hsa-miR-3194-5p hsa-let-7d hsa-miR-548k hsa-miR-548m hsa-let-7g hsa-miR-1244 hsa-let-7a hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmid: TRIB1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIB1 (see all 7)
    OriGene shRNA RFP: TRIB1
    OriGene siRNA: TRIB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIB1
    Sirion Biotech Custom design and validation of potent shRNA sequences against TRIB1 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIB1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TRIB1 (NM_025195)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIB1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIB1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIB1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIB1

    Additional cDNA sequence: 

    AF205437.1 AF250310.1 AJ000480.1 AK001319.1 AK022787.1 AK297539.1 AK307561.1 AL832388.1 
    BC012441.1 BC063292.1 

    9 DOTS entries:

    DT.451897  DT.121472678  DT.92435383  DT.40118059  DT.100673814  DT.75138602  DT.121472668  DT.95170987 
    DT.95352562 

    24/229 AceView cDNA sequences (see all 229):

    AI399784 AA991272 AA968889 BU161806 BF224393 BU682834 AI362767 BM718995 
    AI492079 AI373497 BU521465 AI825569 BM770940 AI392989 Z45957 AI989599 
    AI681167 BC012441 BM804283 AW263066 BU743267 AU125722 BQ425440 AI253126 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TRIB1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c
    SP1:        -     -                       -                     
    SP2:              -                       -                     
    SP3:                                                            
    SP4:                                                            


    ECgene alternative splicing isoforms for TRIB1

    Expression
    for TRIB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGACTTTGAG
    TRIB1 Expression
    About this image

    TRIB1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleMature Granulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Definitive endoderm-like cells (A scalable, suspensi...)

    See TRIB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIB1

    SOURCE GeneReport for Unigene cluster: Hs.444947

    UniProtKB/Swiss-Prot: TRIB1_HUMAN, Q96RU8
    Tissue specificity: Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland,
    pancreas, peripheral blood leukocytes, and bone marrow

        SABiosciences Custom PCR Arrays for TRIB1
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIB1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIB1

    Orthologs
    for TRIB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TRIB1 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Trib11 , 5 tribbles homolog 1 (Drosophila)1, 5 88.35(n)1
    93.82(a)1    		   15 (25.41 cM)5
    2117701  NM_144549.41  NP_653132.11 
     596483505 
    chicken
    (Gallus gallus)    		 Aves LOC4283861 tribbles homolog 1-like 80.76(n)
    91.3(a)    		   428386  XM_425946.3  XP_425946.3 
    lizard
    (Anolis carolinensis)    		 Reptilia TRIB16
    		 --
    		 89(a)
    		 1 ↔ 1
    		 4(5474043-5481571)
    zebrafish
    (Danio rerio)    		 Actinopterygii trib16
    		 tribbles homolog 1 (Drosophila)
    		 49(a)
    		 possible ortholog
    		 19(34574921-34576211)
    fruit fly
    (Drosophila melanogaster)    		 Insecta trbl6
    		 tribbles
    		 24(a)
    		 1 → many
    		 3L(20389388-20394709)
    worm
    (Caenorhabditis elegans)    		 Secernentea nipi-36
    		 No Induction of Peptide after Drechmeria Infection...
    		 10(a)
    		 possible ortholog
    		 X(15607901-15610563)


    ENSEMBL Gene Tree for TRIB1 (if available)
    TreeFam Gene Tree for TRIB1 (if available) 

    Paralogs
    for TRIB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIB1 gene
    STK402  TRIB22  TRIB32  
    18/40 SIMAP similar genes for TRIB1 using alignment to 3 protein entries:     TRIB1_HUMAN (see all proteins) (see all similar genes):
    TRIB2    TRIB3    MARK4    MELK    PKN2    NUAK1
    BRSK2    CAMK2D    OBSCN    CAMK2B    CAMK2G    CAMKK1
    MAP3K4    AKT2    CASK    MAPKAPK3    AURKB    MARK2

    TRIB1 for paralogs           About GeneDecksing



    Genomic Variants
    for TRIB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/234 NCBI SNPs in TRIB1 are shown (see all 234)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1462812921,2
    		--126440563(+) TTAACC/GGCAGC 1 -- us2k10--------
    rs1126067871,2
    		C--126440587(+) CGTTCT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1821874251,2
    		--126440596(+) TTTTTA/TAAATT 1 -- us2k10--------
    rs726473201,2
    		F--126440597(+) TTAAA-/ATTATT 1 -- us2k11Minor allele frequency- A:0.03NS 364
    rs1872637691,2
    		--126440617(+) TTATTA/TTTTAT 1 -- us2k10--------
    rs726473211,2
    		C,F--126440730(+) TCAGCC/TTCCCC 1 -- us2k11Minor allele frequency- T:0.01NS 358
    rs726473221,2
    		C,F--126440799(+) ACGGGG/-TTTCA 1 -- us2k11Minor allele frequency- -:0.07NS 364
    rs726473231,2
    		C,F--126440867(+) AGCCTC/TCCAAA 1 -- us2k11Minor allele frequency- T:0.01NS 364
    rs23851121,2
    		C,F,A,H--126440902(+) ACCACG/ACTTGG 1 -- us2k113Minor allele frequency- A:0.39NA NS WA CSA EA 717
    rs1858288111,2
    		--126440917(+) ACTTCA/GTCCTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRIB1 (126442563 - 126450647 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TRIB1: --
    Human Gene Mutation Database (HGMD): TRIB1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIB1
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    Disorders / Diseases
    for TRIB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRIB1 for disorders           About GeneDecksing

    OMIM gene information: 609461    OMIM disorders: --

    8 diseases for TRIB1:    About MalaCards
    ischemic heart disease    coronary heart disease    familial hypercholesterolemia    hypercholesterolemia
    hypertriglyceridemia    crohn's disease    cholesterol    thyroiditis

    Human Genome Epidemiology (HuGE) Navigator: TRIB1 (22 documents)

    Export disorders for TRIB1 gene to outside databases

    Publications
    for TRIB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIB1 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with TRIB1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells. (PubMed id 9342215)1, 2, 3 Wilkin F.... Maenhaut C. (1997)
    2. Tribbles: novel regulators of cell function; evolutio nary aspects. (PubMed id 16715410)1, 3 Hegedus Z....Kiss-Toth E. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. (PubMed id 15299019)1, 2 Kiss-Toth E.... Dower S.K. (2004)
    5. Tribbles-1 and -2 are tumour suppressors, down-regula ted in human acute myeloid leukaemia. (PubMed id 20005259)1, 9 Gilby D.C....Kiss-Toth E. (2010)
    6. The tribbles gene family and lipoprotein metabolism. (PubMed id 22274752)1 Angyal A. and Kiss-Toth E. (2012)
    7. Finding genes and variants for lipid levels after geno me-wide association analysis. (PubMed id 22418572)1 Willer C.J. and Mohlke K.L. (2012)
    8. Identification of TRIB1 R107L gain-of-function mutatio n in human acute megakaryocytic leukemia. (PubMed id 22294728)1 Yokoyama T....Nakamura T. (2012)
    9. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)1 Toyoshima M....Grandori C. (2012)
    10. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PubMed id 22479202)1 Dastani Z....Kathiresan S. (2012)

    External Searches for TRIB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TRIB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10221 HGNC: 16891 AceView: TRIB1 Ensembl:ENSG00000173334 euGenes: HUgn10221
    ECgene: TRIB1 H-InvDB: TRIB1

    Other Databases showing TRIB1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TRIB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIB1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TRIB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TRIB1 gene:
    Search GeneIP for patents involving TRIB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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