Aliases for TRIAP1 Gene
External Ids for TRIAP1 Gene
Previous GeneCards Identifiers for TRIAP1 Gene
GeneCards Summary for TRIAP1 Gene
TRIAP1 (TP53 Regulated Inhibitor Of Apoptosis 1) is a Protein Coding gene. Among its related pathways are Gene Expression and Direct p53 effectors. GO annotations related to this gene include p53 binding and phosphatidic acid transporter activity.
UniProtKB/Swiss-Prot for TRIAP1 Gene
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003).