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Aliases for TRIAP1 Gene

Aliases for TRIAP1 Gene

  • TP53 Regulated Inhibitor Of Apoptosis 1 2 3
  • P53-Inducible Cell-Survival Factor 2 3 4
  • Protein 15E1.1 3 4
  • HSPC132 3 6
  • P53CSV 3 4
  • WF-1 3 4
  • Mitochondrial Distribution And Morphology 35 Homolog (S. Cerevisiae) 2
  • Mitochondrial Distribution And Morphology 35 Homolog 3
  • TP53-Regulated Inhibitor Of Apoptosis 1 3
  • 15E1.1 4
  • MDM35 3

External Ids for TRIAP1 Gene

Previous GeneCards Identifiers for TRIAP1 Gene

  • GC12M119366
  • GC12M120881
  • GC12M117891

Summaries for TRIAP1 Gene

GeneCards Summary for TRIAP1 Gene

TRIAP1 (TP53 Regulated Inhibitor Of Apoptosis 1) is a Protein Coding gene. Among its related pathways are Direct p53 effectors. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity involved in apoptotic process.

UniProtKB/Swiss-Prot for TRIAP1 Gene

  • Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIAP1 Gene

Genomics for TRIAP1 Gene

Regulatory Elements for TRIAP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIAP1 Gene

Start:
120,443,961 bp from pter
End:
120,446,412 bp from pter
Size:
2,452 bases
Orientation:
Minus strand

Genomic View for TRIAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIAP1 Gene

Proteins for TRIAP1 Gene

  • Protein details for TRIAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43715-TRIA1_HUMAN
    Recommended name:
    TP53-regulated inhibitor of apoptosis 1
    Protein Accession:
    O43715
    Secondary Accessions:
    • B2R4Z7
    • Q5RKS5
    • Q6LCA7

    Protein attributes for TRIAP1 Gene

    Size:
    76 amino acids
    Molecular mass:
    8786 Da
    Quaternary structure:
    • Interacts with APAF1 and HSP70. Forms a complex with PRELID1 in the mitochondrion intermembrane space.
    SequenceCaution:
    • Sequence=AAR00584.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TRIAP1 Gene

Proteomics data for TRIAP1 Gene at MOPED

Post-translational modifications for TRIAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIAP1 Gene

Domains for TRIAP1 Gene

Protein Domains for TRIAP1 Gene

Suggested Antigen Peptide Sequences for TRIAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43715

UniProtKB/Swiss-Prot:

TRIA1_HUMAN :
  • O43715
Family:
  • Belongs to the TRIAP1/MDM35 family.
genes like me logo Genes that share domains with TRIAP1: view

No data available for Gene Families for TRIAP1 Gene

Function for TRIAP1 Gene

Molecular function for TRIAP1 Gene

UniProtKB/Swiss-Prot Function: Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis.
UniProtKB/Swiss-Prot Induction: In p53/TP53-dependent manner in response to low levels of DNA damage. Not induced when DNA damage is severe.

Gene Ontology (GO) - Molecular Function for TRIAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 15735003
GO:0005515 protein binding IPI 15735003
GO:1990050 contributes_to phosphatidic acid transporter activity IDA 23931759
genes like me logo Genes that share ontologies with TRIAP1: view

Phenotypes for TRIAP1 Gene

GenomeRNAi human phenotypes for TRIAP1:
genes like me logo Genes that share phenotypes with TRIAP1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRIAP1 Gene

Localization for TRIAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIAP1 Gene

Cytoplasm, perinuclear region. Mitochondrion. Mitochondrion intermembrane space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIAP1 Gene COMPARTMENTS Subcellular localization image for TRIAP1 gene
Compartment Confidence
mitochondrion 4
cytosol 3
extracellular 3
nucleus 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TRIAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 15735003
GO:0005758 mitochondrial intermembrane space IDA 23931759
GO:0043234 protein complex IDA 23931759
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with TRIAP1: view

Pathways for TRIAP1 Gene

SuperPathways for TRIAP1 Gene

Superpath Contained pathways
1 Direct p53 effectors
genes like me logo Genes that share pathways with TRIAP1: view

Pathways by source for TRIAP1 Gene

1 BioSystems pathway for TRIAP1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TRIAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS 15735003
GO:0015914 phospholipid transport IDA 23931759
GO:0030330 DNA damage response, signal transduction by p53 class mediator IDA 15735003
GO:0034644 cellular response to UV IDA 15735003
GO:0043066 negative regulation of apoptotic process IMP 23931759
genes like me logo Genes that share ontologies with TRIAP1: view

Transcripts for TRIAP1 Gene

mRNA/cDNA for TRIAP1 Gene

Unigene Clusters for TRIAP1 Gene

TP53 regulated inhibitor of apoptosis 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIAP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIAP1 Gene

No ASD Table

Relevant External Links for TRIAP1 Gene

GeneLoc Exon Structure for
TRIAP1
ECgene alternative splicing isoforms for
TRIAP1

Expression for TRIAP1 Gene

mRNA expression in normal human tissues for TRIAP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRIAP1 Gene

SOURCE GeneReport for Unigene cluster for TRIAP1 Gene Hs.69499

genes like me logo Genes that share expressions with TRIAP1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIAP1 Gene

Orthologs for TRIAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIAP1 35
  • 100 (n)
  • 100 (a)
TRIAP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIAP1 35
  • 94.3 (n)
  • 97.37 (a)
TRIAP1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIAP1 35
  • 92.11 (n)
  • 97.37 (a)
TRIAP1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Triap1 35
  • 92.11 (n)
  • 98.68 (a)
Triap1 16
Triap1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Triap1 35
  • 90.79 (n)
  • 98.68 (a)
chicken
(Gallus gallus)
Aves TRIAP1 35
  • 83.33 (n)
  • 82.89 (a)
TRIAP1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIAP1 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20201 35
tropical clawed frog
(Silurana tropicalis)
Amphibia triap1 35
  • 75.68 (n)
  • 75.68 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7129 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17876 35
triap1 35
  • 75.23 (n)
  • 74.32 (a)
triap1 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30108 36
  • 39 (a)
OneToMany
CG30109 36
  • 36 (a)
OneToMany
Species with no ortholog for TRIAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIAP1 Gene

ENSEMBL:
Gene Tree for TRIAP1 (if available)
TreeFam:
Gene Tree for TRIAP1 (if available)

Paralogs for TRIAP1 Gene

Pseudogenes.org Pseudogenes for TRIAP1 Gene

genes like me logo Genes that share paralogs with TRIAP1: view

No data available for Paralogs for TRIAP1 Gene

Variants for TRIAP1 Gene

Sequence variations from dbSNP and Humsavar for TRIAP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs10293 -- 120,444,034(+) GTAAA(A/C)AAGGC utr-variant-3-prime
rs1048830 -- 120,444,414(-) CACAA(A/C)AGTTT utr-variant-3-prime
rs1151845 -- 120,443,485(+) GTACC(A/G)TAGTG downstream-variant-500B
rs3809309 -- 120,444,114(+) TGCAT(A/C/T)TCCTA utr-variant-3-prime
rs113278902 -- 120,443,788(+) GTCTC(-/A)AAAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TRIAP1 Gene

Variant ID Type Subtype PubMed ID
nsv509482 CNV Insertion 20534489
nsv819389 CNV Loss 19587683

Relevant External Links for TRIAP1 Gene

HapMap Linkage Disequilibrium report
TRIAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIAP1 Gene

Disorders for TRIAP1 Gene

(4) University of Copenhagen DISEASES for TRIAP1 Gene

Relevant External Links for TRIAP1

Genetic Association Database (GAD)
TRIAP1
Human Genome Epidemiology (HuGE) Navigator
TRIAP1
genes like me logo Genes that share disorders with TRIAP1: view

No data available for UniProtKB/Swiss-Prot for TRIAP1 Gene

Publications for TRIAP1 Gene

  1. p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway. (PMID: 15735003) Park W.-R. … Nakamura Y. (Cancer Res. 2005) 2 3 4 23
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid. (PMID: 23931759) Potting C. … Langer T. (Cell Metab. 2013) 3 4

Products for TRIAP1 Gene

  • antibodies-online proteins for TRIAP1
  • antibodies-online antibodies for TRIAP1
  • antibodies-online kits for TRIAP1

Sources for TRIAP1 Gene

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