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Aliases for TRIAP1 Gene

Aliases for TRIAP1 Gene

  • TP53 Regulated Inhibitor Of Apoptosis 1 2 3 5
  • P53-Inducible Cell-Survival Factor 2 3 4
  • Protein 15E1.1 3 4
  • P53CSV 3 4
  • WF-1 3 4
  • Mitochondrial Distribution And Morphology 35 Homolog (S. Cerevisiae) 2
  • Mitochondrial Distribution And Morphology 35 Homolog 3
  • TP53-Regulated Inhibitor Of Apoptosis 1 3
  • HSPC132 3
  • 15E1.1 4
  • MDM35 3

External Ids for TRIAP1 Gene

Previous GeneCards Identifiers for TRIAP1 Gene

  • GC12M119366
  • GC12M120881
  • GC12M117891

Summaries for TRIAP1 Gene

GeneCards Summary for TRIAP1 Gene

TRIAP1 (TP53 Regulated Inhibitor Of Apoptosis 1) is a Protein Coding gene. Among its related pathways are Gene Expression and TP53 Regulates Transcription of Cell Death Genes. GO annotations related to this gene include p53 binding and phosphatidic acid transporter activity.

UniProtKB/Swiss-Prot for TRIAP1 Gene

  • Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIAP1 Gene

Genomics for TRIAP1 Gene

Regulatory Elements for TRIAP1 Gene

Enhancers for TRIAP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F120473 1.3 Ensembl ENCODE 12 -28.3 -28256 2.0 PKNOX1 SIN3A ZNF121 ZNF366 RCOR1 FOS CREM EGR2 ZNF263 ZNF362 COQ5 RPL31P52 TRIAP1 ENSG00000111780 NRAV COX6A1 PLA2G1B DYNLL1
GH12F120476 0.7 Ensembl 11.8 -30.1 -30089 0.2 SMARCA4 POLR2A NRF1 MAX MNT MYC RPL31P52 TRIAP1 ENSG00000111780 COX6A1 MSI1 RPS27P25 DYNLL1 NRAV
GH12F120479 0.2 ENCODE 11.8 -34.5 -34508 2.8 HDAC1 PKNOX1 CBX3 TBL1XR1 TAL1 ZMYM3 ZNF175 GATA2 NCOR1 FOS GATC RPL31P52 TRIAP1 ENSG00000111780 COX6A1 COQ5 MSI1 RPS27P25 DYNLL1 NRAV
GH12F120489 0.5 ENCODE 11.5 -42.8 -42821 0.2 KLF1 ATF1 JUN ZNF366 ZNF600 ZEB2 TSHZ1 ATF2 JUND ZNF692 RPL31P52 TRIAP1 ENSG00000111780 COX6A1 NRAV DYNLL1
GH12F120487 0.2 ENCODE 11.5 -41.7 -41664 1.2 HDAC1 PKNOX1 KLF17 ZNF335 ZNF366 GATA2 FOS EGR2 ZEB2 MBD2 GATC COQ5 RPL31P52 TRIAP1 ENSG00000111780 COX6A1 NRAV DYNLL1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TRIAP1 on UCSC Golden Path with GeneCards custom track

Promoters for TRIAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000438148 112 2201 HDGF ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for TRIAP1 Gene

Chromosome:
12
Start:
120,443,961 bp from pter
End:
120,446,412 bp from pter
Size:
2,452 bases
Orientation:
Minus strand

Genomic View for TRIAP1 Gene

Genes around TRIAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIAP1 Gene

Proteins for TRIAP1 Gene

  • Protein details for TRIAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43715-TRIA1_HUMAN
    Recommended name:
    TP53-regulated inhibitor of apoptosis 1
    Protein Accession:
    O43715
    Secondary Accessions:
    • B2R4Z7
    • Q5RKS5
    • Q6LCA7

    Protein attributes for TRIAP1 Gene

    Size:
    76 amino acids
    Molecular mass:
    8786 Da
    Quaternary structure:
    • Monomer (PubMed:26071602). Interacts with APAF1 and HSP70 (PubMed:15735003). Forms a complex with PRELID1 in the mitochondrion intermembrane space (PubMed:23931759). Interacts with PRELID3A (PubMed:26071602).
    SequenceCaution:
    • Sequence=AAR00584.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIAP1 Gene

neXtProt entry for TRIAP1 Gene

Post-translational modifications for TRIAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIAP1 Gene

Domains & Families for TRIAP1 Gene

Protein Domains for TRIAP1 Gene

Suggested Antigen Peptide Sequences for TRIAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43715

UniProtKB/Swiss-Prot:

TRIA1_HUMAN :
  • Contains 1 CHCH (coiled coil-helix-coiled coil-helix) domain.
  • Belongs to the TRIAP1/MDM35 family.
Domain:
  • Contains 1 CHCH (coiled coil-helix-coiled coil-helix) domain.
Family:
  • Belongs to the TRIAP1/MDM35 family.
genes like me logo Genes that share domains with TRIAP1: view

No data available for Gene Families for TRIAP1 Gene

Function for TRIAP1 Gene

Molecular function for TRIAP1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003).
UniProtKB/Swiss-Prot Induction:
In p53/TP53-dependent manner in response to low levels of DNA damage. Not induced when DNA damage is severe.

Gene Ontology (GO) - Molecular Function for TRIAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 15735003
GO:0005515 protein binding IPI 15735003
GO:1990050 contributes_to phosphatidic acid transporter activity IDA 23931759
genes like me logo Genes that share ontologies with TRIAP1: view
genes like me logo Genes that share phenotypes with TRIAP1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIAP1 Gene

Localization for TRIAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIAP1 Gene

Cytoplasm, perinuclear region. Mitochondrion. Mitochondrion intermembrane space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIAP1 Gene COMPARTMENTS Subcellular localization image for TRIAP1 gene
Compartment Confidence
mitochondrion 5
cytosol 4
extracellular 3
nucleus 2

Gene Ontology (GO) - Cellular Components for TRIAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA,IDA 15735003
GO:0005758 mitochondrial intermembrane space IEA,TAS --
GO:0043234 protein complex IDA 23931759
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with TRIAP1: view

Pathways & Interactions for TRIAP1 Gene

genes like me logo Genes that share pathways with TRIAP1: view

Gene Ontology (GO) - Biological Process for TRIAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006869 lipid transport IEA --
GO:0006915 apoptotic process IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS 15735003
GO:0015914 phospholipid transport IDA 26071602
genes like me logo Genes that share ontologies with TRIAP1: view

No data available for SIGNOR curated interactions for TRIAP1 Gene

Transcripts for TRIAP1 Gene

mRNA/cDNA for TRIAP1 Gene

Unigene Clusters for TRIAP1 Gene

TP53 regulated inhibitor of apoptosis 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIAP1 Gene

No ASD Table

Relevant External Links for TRIAP1 Gene

GeneLoc Exon Structure for
TRIAP1
ECgene alternative splicing isoforms for
TRIAP1

Expression for TRIAP1 Gene

mRNA expression in normal human tissues for TRIAP1 Gene

Protein differential expression in normal tissues from HIPED for TRIAP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIAP1 Gene



Protein tissue co-expression partners for TRIAP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIAP1 Gene:

TRIAP1

SOURCE GeneReport for Unigene cluster for TRIAP1 Gene:

Hs.69499
genes like me logo Genes that share expression patterns with TRIAP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIAP1 Gene

Orthologs for TRIAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIAP1 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia TRIAP1 34 35
  • 94.3 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 93 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TRIAP1 34 35
  • 92.11 (n)
mouse
(Mus musculus)
Mammalia Triap1 34 16 35
  • 92.11 (n)
rat
(Rattus norvegicus)
Mammalia Triap1 34
  • 90.79 (n)
chicken
(Gallus gallus)
Aves TRIAP1 34 35
  • 83.33 (n)
lizard
(Anolis carolinensis)
Reptilia TRIAP1 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia triap1 34
  • 75.68 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20201 34
zebrafish
(Danio rerio)
Actinopterygii triap1 34 35
  • 75.23 (n)
Dr.17876 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7129 34
fruit fly
(Drosophila melanogaster)
Insecta CG30108 35
  • 39 (a)
OneToMany
CG30109 35
  • 36 (a)
OneToMany
Species where no ortholog for TRIAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIAP1 Gene

ENSEMBL:
Gene Tree for TRIAP1 (if available)
TreeFam:
Gene Tree for TRIAP1 (if available)

Paralogs for TRIAP1 Gene

Pseudogenes.org Pseudogenes for TRIAP1 Gene

genes like me logo Genes that share paralogs with TRIAP1: view

No data available for Paralogs for TRIAP1 Gene

Variants for TRIAP1 Gene

Sequence variations from dbSNP and Humsavar for TRIAP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10293 -- 120,444,034(+) GTAAA(A/C)AAGGC utr-variant-3-prime
rs1048830 -- 120,444,414(-) CACAA(A/C)AGTTT utr-variant-3-prime
rs111315290 -- 120,445,101(+) AAAAA(C/G)AAGTA intron-variant, upstream-variant-2KB
rs112148729 -- 120,445,211(+) CATGG(C/T)GAGAC intron-variant, upstream-variant-2KB
rs113027568 -- 120,448,024(+) ACTGG(A/G)ATTAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIAP1 Gene

Variant ID Type Subtype PubMed ID
esv3630923 CNV gain 21293372
nsv509482 CNV insertion 20534489
nsv819389 CNV loss 19587683

Variation tolerance for TRIAP1 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIAP1 Gene

Disorders for TRIAP1 Gene

Relevant External Links for TRIAP1

Genetic Association Database (GAD)
TRIAP1
Human Genome Epidemiology (HuGE) Navigator
TRIAP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIAP1

No disorders were found for TRIAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIAP1 Gene

Publications for TRIAP1 Gene

  1. p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway. (PMID: 15735003) Park W.-R. … Nakamura Y. (Cancer Res. 2005) 2 3 4 22 64
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  3. Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes. (PMID: 26071602) Miliara X. … Matthews S. (EMBO Rep. 2015) 3 4 64
  4. TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid. (PMID: 23931759) Potting C. … Langer T. (Cell Metab. 2013) 3 4 64
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64

Products for TRIAP1 Gene

Sources for TRIAP1 Gene

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