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Aliases for TRHR Gene

Aliases for TRHR Gene

  • Thyrotropin-Releasing Hormone Receptor 2 3
  • Thyroliberin Receptor 3 4
  • TRH-R 3 4

External Ids for TRHR Gene

Summaries for TRHR Gene

Entrez Gene Summary for TRHR Gene

  • This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]

GeneCards Summary for TRHR Gene

TRHR (Thyrotropin-Releasing Hormone Receptor) is a Protein Coding gene. Diseases associated with TRHR include resistance to thyrotropin-releasing hormone syndrome and prolactinoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include thyrotropin-releasing hormone receptor activity. An important paralog of this gene is GPR39.

UniProtKB/Swiss-Prot for TRHR Gene

  • Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system

Tocris Summary for TRHR Gene

  • Thyrotropin-releasing hormone (TRH) receptors are Gq/11-protein-coupled receptors that promote thyroid-stimulating hormone (TSH) and prolactin (PRL) release. Two TRH receptor subtypes, TRH1 and TRH2, have been identified in rodents, but only the TRH1 receptor has been found in humans. TRH1 is predominantly expressed in the anterior pituitary gland, but is also found at appreciable levels in the brain, pancreas, testis, adrenals and lymphoid organs. The human gene encoding the TRH1 receptor is located on chromosome 8q23.1.

Gene Wiki entry for TRHR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRHR Gene

Genomics for TRHR Gene

Genomic Location for TRHR Gene

109,086,621 bp from pter
109,119,584 bp from pter
32,964 bases
Plus strand

Genomic View for TRHR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRHR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRHR Gene

Regulatory Elements for TRHR Gene

Proteins for TRHR Gene

  • Protein details for TRHR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thyrotropin-releasing hormone receptor
    Protein Accession:
    Secondary Accessions:
    • Q2M339

    Protein attributes for TRHR Gene

    398 amino acids
    Molecular mass:
    45085 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRHR Gene

Proteomics data for TRHR Gene at MOPED

Post-translational modifications for TRHR Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn3 and Asn10

Other Protein References for TRHR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TRHR Gene

Domains for TRHR Gene

Protein Domains for TRHR Gene


  • Belongs to the G-protein coupled receptor 1 family.:
    • P34981
genes like me logo Genes that share domains with TRHR: view

Function for TRHR Gene

Molecular function for TRHR Gene

GENATLAS Biochemistry: thyrotropin releasing hormone receptor,neurotransmitter and neuro regulator,involved in the thyroid hormones secretion and metabolic pathway
UniProtKB/Swiss-Prot Function: Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system

Gene Ontology (GO) - Molecular Function for TRHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004997 thyrotropin-releasing hormone receptor activity IEA --
genes like me logo Genes that share ontologies with TRHR: view
genes like me logo Genes that share phenotypes with TRHR: view

Animal Models for TRHR Gene

MGI Knock Outs for TRHR:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TRHR Gene

Localization for TRHR Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRHR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TRHR Gene COMPARTMENTS Subcellular localization image for TRHR gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TRHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8395824
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with TRHR: view

Pathways for TRHR Gene

genes like me logo Genes that share pathways with TRHR: view

Gene Ontology (GO) - Biological Process for TRHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with TRHR: view

Compounds for TRHR Gene

(1) Tocris Compounds for TRHR Gene

Compound Action Cas Number
Taltirelin Synthetic thyrotropin-releasing hormone analog [103300-74-9]

(1) HMDB Compounds for TRHR Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(2) IUPHAR Ligand for TRHR Gene

Ligand Type Action Affinity Pubmed IDs
MeTRH Agonist Partial agonist 8.5
taltirelin Agonist Full agonist 6.5

(12) Novoseek inferred chemical compound relationships for TRHR Gene

Compound -log(P) Hits PubMed IDs
chlordiazepoxide 54.3 1
tripeptide 49 2
phosphoinositide 25.2 1
calcium 22.4 6
cycloheximide 20.1 1
genes like me logo Genes that share compounds with TRHR: view

Transcripts for TRHR Gene

mRNA/cDNA for TRHR Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRHR Gene

Thyrotropin-releasing hormone receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRHR Gene

No ASD Table

Relevant External Links for TRHR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRHR Gene

mRNA expression in normal human tissues for TRHR Gene

mRNA differential expression in normal tissues according to GTEx for TRHR Gene

This gene is overexpressed in Pituitary (17.6).

SOURCE GeneReport for Unigene cluster for TRHR Gene Hs.3022

genes like me logo Genes that share expressions with TRHR: view

Orthologs for TRHR Gene

This gene was present in the common ancestor of animals.

Orthologs for TRHR Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRHR 36
  • 99.5 (n)
  • 99.75 (a)
  • 100 (a)
(Bos Taurus)
Mammalia TRHR 36
  • 92.96 (n)
  • 95.98 (a)
  • 96 (a)
(Canis familiaris)
Mammalia TRHR 36
  • 94.47 (n)
  • 97.49 (a)
  • 97 (a)
(Mus musculus)
Mammalia Trhr 36
  • 90.48 (n)
  • 94.64 (a)
Trhr 16
Trhr 37
  • 94 (a)
(Monodelphis domestica)
Mammalia TRHR 37
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia TRHR 37
  • 80 (a)
(Rattus norvegicus)
Mammalia Trhr 36
  • 89.8 (n)
  • 95.41 (a)
(Gallus gallus)
Aves TRHR 36
  • 76.19 (n)
  • 82.65 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia TRHR 37
  • 82 (a)
African clawed frog
(Xenopus laevis)
Amphibia trhr-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia trhr 36
  • 74.17 (n)
  • 81.07 (a)
(Danio rerio)
Actinopterygii trhra 36
  • 66.57 (n)
  • 71.23 (a)
trhra 37
  • 66 (a)
trhrb 37
  • 64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRNPR1 36
  • 47 (n)
  • 39.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta ETHR 37
  • 22 (a)
(Caenorhabditis elegans)
Secernentea npr-15 37
  • 23 (a)
npr-33 37
  • 19 (a)
C30F12.6 38
  • 39 (a)
Species with no ortholog for TRHR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRHR Gene

Gene Tree for TRHR (if available)
Gene Tree for TRHR (if available)

Paralogs for TRHR Gene

Paralogs for TRHR Gene

genes like me logo Genes that share paralogs with TRHR: view

Variants for TRHR Gene

Sequence variations from dbSNP and Humsavar for TRHR Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs5772 -- 109,086,403(+) ACTTA(C/G)ATGAT upstream-variant-2KB
rs5773 -- 109,086,431(+) GCTGC(C/T)TCTAG upstream-variant-2KB
rs5774 - 109,087,542(+) CTGAA(A/C)CAAAC missense, reference
rs5775 -- 109,087,635(+) ATTGT(A/G)GGCAA reference, synonymous-codon
rs5776 -- 109,119,407(+) GTGTC(C/T)TTTGA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for TRHR Gene

Variant ID Type Subtype PubMed ID
nsv891271 CNV Gain 21882294
esv269909 CNV Insertion 20981092
esv272700 CNV Insertion 20981092
esv1010309 CNV Insertion 20482838
esv270168 CNV Insertion 20981092

Relevant External Links for TRHR Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for TRHR Gene

(1) University of Copenhagen DISEASES for TRHR Gene

(9) Novoseek inferred disease relationships for TRHR Gene

Disease -log(P) Hits PubMed IDs
pituitary adenoma 46.5 6
adenoma 40 4
acromegaly 38.5 5
prolactinoma 37.3 1
hypothyroidism 36.1 5

Genatlas disease for TRHR Gene

isolated central hypothyroidism with TSH and PRL levels unresponsive to TRH (inactivating mutations of TRHR)

Relevant External Links for TRHR

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TRHR: view

No data available for UniProtKB/Swiss-Prot for TRHR Gene

Publications for TRHR Gene

  1. Cloning and functional characterisation of the human TRH receptor. (PMID: 8243797) Duthie S.M. … Eidne K.A. (Mol. Cell. Endocrinol. 1993) 3 4 23
  2. Genomic organization and promoter function of the human thyrotropin- releasing hormone receptor gene. (PMID: 8703031) Iwasaki T. … Mori M. (J. Biol. Chem. 1996) 3 4 23
  3. A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor. (PMID: 8770906) Cook J.V. … Eidne K.A. (Endocrinology 1996) 3 4 23
  4. Molecular cloning of a functional human thyrotropin-releasing hormone receptor. (PMID: 8395824) Matre V. … Gautvik K.M. (Biochem. Biophys. Res. Commun. 1993) 3 4 23
  5. Pituitary adenomas of patients with acromegaly express thyrotropin- releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene. (PMID: 8396925) Yamada M. … Mori M. (Biochem. Biophys. Res. Commun. 1993) 3 4 23

Products for TRHR Gene

Sources for TRHR Gene

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