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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRHR Gene

protein-coding   GIFtS: 61
GCID: GC08P110168

thyrotropin-releasing hormone receptor

 Explore 15 diseases affiliated with
TRHR via our new
 Human Malady Compendium 
Biological research products
for TRHR
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Thyrotropin-Releasing Hormone Receptor1 2
Thyroliberin Receptor2 3
TRH-R2 3

External Ids:    HGNC: 122991   Entrez Gene: 72012   Ensembl: ENSG000001744177   OMIM: 1885455   UniProtKB: P349813   

Export aliases for TRHR gene to outside databases

Previous GC identifers: GC08P109084 GC08P110167 GC08P109768 GC08P110056 GC08P105422


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRHR:
This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this
receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene
have been associated with generalized thyrotropin-releasing hormone resistance. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: TRFR_HUMAN, P34981
Function: Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a
phosphatidylinositol-calcium second messenger system

summary for TRHR:
Thyrotropin-releasing hormone (TRH) receptors are Gq/11-protein-coupled receptors that promote
thyroid-stimulating hormone (TSH) and prolactin (PRL) release. Two TRH receptor subtypes, TRH1 and TRH2,
have been identified in rodents, but only the TRH1 receptor has been found in humans. TRH1 is predominantly
expressed in the anterior pituitary gland, but is also found at appreciable levels in the brain, pancreas,
testis, adrenals and lymphoid organs. The human gene encoding the TRH1 receptor is located on chromosome
8q23.1.

Gene Wiki entry for TRHR (Thyrotropin-releasing hormone receptor)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRHR gene promoter:
         c-Fos   RFX1   AP-1   JunB   FosB   Fra-1   Evi-1   JunD   c-Myb   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRHR promoter sequence
   Search SABiosciences Chromatin IP Primers for TRHR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRHR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23   Ensembl cytogenetic band:  8q23.1   HGNC chromosome: 8

TRHR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRHR gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P110168:  view genomic region     (about GC identifiers)

Start:
110,098,850 bp from pter      End:
110,131,813 bp from pter
Size:
32,964 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRFR_HUMAN, P34981 (See protein sequence)
Recommended Name: Thyrotropin-releasing hormone receptor  
Size: 398 amino acids; 45085 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q2M339

Explore the universe of human proteins at neXtProt for TRHR: NX_P34981

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P34981

  • TRHR Protein expression data from MOPED and PaxDb:    About this image 
    TRHR Protein Expression
    REFSEQ proteins: NP_003292.1  
    ENSEMBL proteins: 
     ENSP00000430711   ENSP00000309818  
    Reactome Protein details: P34981
    Human Recombinant Protein Products for TRHR: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TRHR

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8395824
    GO:0009986cell surface ----

    TRHR for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TRHR


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TRHR for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR009144 Thyrotropin_RHR
     IPR002120 Trelhrm_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P34981

    ProtoNet protein and cluster: P34981

    1 Blocks protein family: IPB002120 Thyrotrophin-releasing hormone receptor signature

    UniProtKB/Swiss-Prot: TRFR_HUMAN, P34981
    Similarity: Belongs to the G-protein coupled receptor 1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRFR_HUMAN, P34981
    Function: Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a
    phosphatidylinositol-calcium second messenger system

         Genatlas biochemistry entry for TRHR:
    thyrotropin releasing hormone receptor,neurotransmitter and neuro regulator,involved in the thyroid hormones secretion
    and metabolic pathway

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004997thyrotropin-releasing hormone receptor activity IEA--
    GO:0042803protein homodimerization activity ----
         
    TRHR for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TRHR:
     Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Trhr):
     behavior/neurological  growth/size  homeostasis/metabolism  reproductive system 

    TRHR for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Trhrtm1Hzg for TRHR
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TRHR 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRHR
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Sirion Biotech Customized inducible overexpressing cell line services for TRHR

    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRHR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)1.00
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.75
    Neuroactive ligand-receptor interaction0.38
    Peptide ligand-binding receptors0.61
    2Signaling by GPCR
    Signaling by GPCR1.00
    Signal Transduction0.56
    GPCR downstream signaling0.89
    3G alpha (q) signalling events
    G alpha (q) signalling events1.00
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    4Selected targets of GCR-alpha
    Selected targets of GCR-alpha1.00
    5Calcium signaling pathway
    Calcium signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TRHR
        Selected targets of GCR-alpha


    2 BioSystems Pathways for TRHR 
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    5/8        Reactome Pathways for TRHR (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding


    2         Kegg Pathways  (Kegg details for TRHR):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction


    TRHR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRHR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/126 Interacting proteins for TRHR (P349813 ENSP000003098184) via UniProtKB, MINT, STRING, and/or I2D (see all 126)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRHP203963, ENSP000003034524I2D: score=1 STRING: ENSP00000303452
    ARRB1P494073, ENSP000003771414I2D: score=1 STRING: ENSP00000377141
    ADRA1BENSP000003066624STRING: ENSP00000306662
    ADRA1DENSP000003687664STRING: ENSP00000368766
    ADRBK1ENSP000003122624STRING: ENSP00000312262
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS8395824
    GO:0007204elevation of cytosolic calcium ion concentration ----
    GO:0090073positive regulation of protein homodimerization activity ----

    TRHR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRHR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for TRHR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TaltirelinSynthetic thyrotropin-releasing hormone (TRH) analog[103300-74-9]

    1 HMDB Compound for TRHR    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    10/12 Novoseek chemical compound relationships for TRHR gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chlordiazepoxide 54.3 1 8584022 (1)
    tripeptide 49 2 8672465 (1), 17123625 (1)
    phosphoinositide 25.2 1 8120038 (1)
    calcium 22.4 9 7501234 (2), 18948837 (1), 18724972 (1), 7525072 (1) (see all 5)
    cycloheximide 20.1 1 8247016 (1)
    inositol 1,4,5 trisphosphate 12.9 1 8045988 (1)
    guanine 12.8 2 8584022 (1), 8247012 (1)
    alanine 11 1 9855624 (1)
    isoproterenol 4.99 1 15673926 (1)
    silver 1.74 1 9003021 (1)

    Search CenterWatch for drugs/clinical trials and news about TRHR / TRFR 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRHR gene: 
    NM_003301.5  

    Unigene Cluster for TRHR:

    Thyrotropin-releasing hormone receptor
    Hs.3022  [show with all ESTs]
    Unigene Representative Sequence: NM_003301
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000518632 ENST00000311762(uc003ymz.4)

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    Sirion Biotech Custom design and validation of potent shRNA sequences against TRHR 
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    Additional cDNA sequence: 

    AY493373.1 BC105045.1 BC113360.1 D16845.1 X72089.1 X75071.1 

    1 DOTS entry:

    DT.208516 

    5 AceView cDNA sequences:

    D16845 X75071 AY493373 X72089 NM_003301 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRHR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCCAGAAAT
    TRHR Expression
    About this image
    See TRHR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRHR

    SOURCE GeneReport for Unigene cluster: Hs.3022
        SABiosciences Expression via Pathway-Focused PCR Arrays including TRHR: 

              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRHR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TRHR gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TRHR1 thyrotropin-releasing hormone receptor 76.19(n)
    82.65(a)
      395770  NM_204930.1  NP_990261.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRHR6
    --
    80(a)
    1 ↔ 1
    4(10885449-10915045)
    African clawed frog
    (Xenopus laevis)
    Amphibia trhr-A2 thyrotropin-releasing hormone receptor 76.13(n)    AF305620.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5588781 thyrotropin-releasing hormone receptor-like 66.57(n)
    71.23(a)
      558878  XM_682154.3  XP_687246.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta ETHR1 CG5911-PA 45.67(n)
    35.99(a)
      42523  NM_142703.2  NP_650960.2 
    worm
    (Caenorhabditis elegans)
    Secernentea C30F12.63 seven trans-membrane receptor 39(a)   I(6997164-6999907)   --


    ENSEMBL Gene Tree for TRHR (if available)
    TreeFam Gene Tree for TRHR (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRHR gene
    NTSR12  GPR392  GHSR2  NMUR12  MLNR2  NMUR22  NTSR22  

    TRHR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/501 NCBI SNPs in TRHR are shown (see all 501    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219178471,2
    Cpathogenic105421520(+) AGCCAC/TGAGCA 2 R * stg10--------
    rs344619681,2
    F--105419837(+) GTTTGG/CTAACA 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs57731,2
    C,H--105420394(+) GCTGCT/CTCTAG 1 -- us2k17Minor allele frequency- C:0.01MN NS EA NA 490
    rs133060591,2
    C,H--105420567(+) AGAGCG/AAGCGA 1 -- us2k14Minor allele frequency- A:0.00NS EA 402
    rs1131869741,2
    C--105422476(+) AGCAGG/TCATCA 1 -- int11Minor allele frequency- T:0.50NA 2
    rs799158881,2
    F--105423019(+) TTGAAT/CAGTGG 1 -- int11Minor allele frequency- C:0.03WA 118
    rs737027691,2
    C--105423247(+) AACATG/ACTGAT 1 -- int12Minor allele frequency- A:0.14WA 120
    rs598269781,2
    C--105423864(+) ACTTAC/TTATTA 1 -- int11Minor allele frequency- T:0.50WA 2
    rs749225191,2
    C,F--105423981(+) TTTATT/CACCCA 1 -- int11Minor allele frequency- C:0.03NA 120
    rs726807121,2
    C,F--105424052(+) AAATAT/CAATAA 1 -- int11Minor allele frequency- C:0.02NA 120

    HapMap Linkage Disequilibrium report for TRHR (110098850 - 110131813 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TRHR: --
    Human Gene Mutation Database (HGMD): TRHR

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for TRHR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TRHR for disorders           About GeneDecksing

    OMIM gene information: 188545    OMIM disorders: --

    15 diseases for TRHR:    About MalaCards
    thyrotropin-releasing hormone resistance    thyrotropin-releasing hormone resistance, generalized    thyroiditis    pituitary adenoma
    prolactinoma    pituitary tumor    acromegaly    hyperthyroidism
    hypothyroidism    essential hypertension    adenoma    aldosteronism
    hypertension    lung cancer    pancreatitis

    9 Novoseek disease relationships for TRHR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary adenoma 46.5 10 8396925 (3), 14594554 (1), 9398744 (1), 10199161 (1)
    adenoma 40 20 14599121 (3), 8396925 (1)
    acromegaly 38.5 10 8396925 (3), 14594554 (1), 14599121 (1)
    prolactinoma 37.3 2 14599121 (1)
    hypothyroidism 36.1 9 11857914 (2), 14594554 (1), 9702078 (1), 9141550 (1)
    pituitary tumors 29 6 9398744 (2), 10199161 (1)
    hyperthyroidism 13.3 2 10219918 (2)
    tumors 0 5 8772588 (4), 14594554 (1)
    lymphoma 0 3 15673926 (1), 15209537 (1)

    Genatlas disease: TRHR
    isolated central hypothyroidism with TSH and PRL levels unresponsive to TRH (inactivating mutations of TRHR)

    Genetic Association Database (GAD): TRHR
    Human Genome Epidemiology (HuGE) Navigator: TRHR (4 documents)

    Export disorders for TRHR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRHR gene, integrated from 9 sources (see all 97):
    (articles sorted by number of sources associating them with TRHR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Pituitary adenomas of patients with acromegaly express thyrotropin- releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene. (PubMed id 8396925)1, 2, 9 Yamada M.... Mori M. (1993)
    2. A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor. (PubMed id 8770906)1, 2, 9 Cook J.V.... Eidne K.A. (1996)
    3. Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor. (PubMed id 9886052)1, 2, 9 Matre V.... Gautvik K.M. (1999)
    4. Cloning and functional characterisation of the human TRH receptor. (PubMed id 8243797)1, 2, 9 Duthie S.M.... Eidne K.A. (1993)
    5. Molecular cloning of a functional human thyrotropin-releasing hormone receptor. (PubMed id 8395824)1, 2, 9 Matre V.... Gautvik K.M. (1993)
    6. Genomic organization and promoter function of the human thyrotropin- releasing hormone receptor gene. (PubMed id 8703031)1, 2, 9 Iwasaki T.... Mori M. (1996)
    7. Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8. (PubMed id 8128317)1, 3, 9 Yamada M....Mori M. (1993)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Molecular cloning and functional expression of a human thyrotropin- releasing hormone (TRH) receptor gene. (PubMed id 7918619)1, 2 Hinuma S.... Onda H. (1994)
    10. Thyrotropin-releasing hormone receptor (TRHR) gene is associated with essential hypertension. (PubMed id 11566956)4, 9 Garcia S.I....Pirola C.J. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7201 HGNC: 12299 AceView: TRHR Ensembl:ENSG00000174417 euGenes: HUgn7201
    ECgene: TRHR Kegg: 7201 H-InvDB: TRHR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRHR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRHR gene:
    Search GeneIP for patents involving TRHR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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