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TRHR Gene

protein-coding   GIFtS: 66
GCID: GC08P110168

Thyrotropin-Releasing Hormone Receptor

  See TRHR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thyrotropin-Releasing Hormone Receptor1 2
Thyroliberin Receptor2 3
TRH-R2 3

External Ids:    HGNC: 122991   Entrez Gene: 72012   Ensembl: ENSG000001744177   OMIM: 1885455   UniProtKB: P349813   

Export aliases for TRHR gene to outside databases

Previous GC identifers: GC08P109084 GC08P110167 GC08P109768 GC08P110056 GC08P105422


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRHR Gene:
This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this
receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this
gene have been associated with generalized thyrotropin-releasing hormone resistance. (provided by RefSeq, Sep
2011)

GeneCards Summary for TRHR Gene:
TRHR (thyrotropin-releasing hormone receptor) is a protein-coding gene. Diseases associated with TRHR include resistance to thyrotropin-releasing hormone syndrome, and thyrotropin-releasing hormone resistance, generalized. GO annotations related to this gene include thyrotropin-releasing hormone receptor activity. An important paralog of this gene is GHSR.

UniProtKB/Swiss-Prot: TRFR_HUMAN, P34981
Function: Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a
phosphatidylinositol-calcium second messenger system

summary for TRHR Gene:
Thyrotropin-releasing hormone (TRH) receptors are Gq/11-protein-coupled receptors that promote
thyroid-stimulating hormone (TSH) and prolactin (PRL) release. Two TRH receptor subtypes, TRH1 and TRH2,
have been identified in rodents, but only the TRH1 receptor has been found in humans. TRH1 is predominantly
expressed in the anterior pituitary gland, but is also found at appreciable levels in the brain, pancreas,
testis, adrenals and lymphoid organs. The human gene encoding the TRH1 receptor is located on chromosome
8q23.1.

Gene Wiki entry for TRHR (Thyrotropin-releasing hormone receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRHR gene promoter:
         c-Fos   RFX1   AP-1   JunB   FosB   Fra-1   Evi-1   JunD   c-Myb   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRHR promoter sequence
   Search Chromatin IP Primers for TRHR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRHR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23   Ensembl cytogenetic band:  8q23.1   HGNC cytogenetic band: 8q23.1

TRHR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRHR gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P110168:  view genomic region     (about GC identifiers)

Start:
110,098,850 bp from pter      End:
110,131,813 bp from pter
Size:
32,964 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRFR_HUMAN, P34981 (See protein sequence)
Recommended Name: Thyrotropin-releasing hormone receptor  
Size: 398 amino acids; 45085 Da
Secondary accessions: Q2M339

Explore the universe of human proteins at neXtProt for TRHR: NX_P34981

Explore proteomics data for TRHR at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn3, Asn10
  • Modification sites at PhosphoSitePlus

  • See TRHR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003292.1  
    ENSEMBL proteins: 
     ENSP00000430711   ENSP00000309818  
    Reactome Protein details: P34981

    TRHR Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TRHR

     
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    Search eBioscience for ELISAs for TRHR 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: TRH1 receptor
    Thyrotropin-releasing hormone receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002120 TRH_rcpt_1
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P34981

    ProtoNet protein and cluster: P34981

    1 Blocks protein domain: IPB002120 Thyrotrophin-releasing hormone receptor signature

    UniProtKB/Swiss-Prot: TRFR_HUMAN, P34981
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with TRHR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRFR_HUMAN, P34981
    Function: Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a
    phosphatidylinositol-calcium second messenger system

         Genatlas biochemistry entry for TRHR:
    thyrotropin releasing hormone receptor,neurotransmitter and neuro regulator,involved in the thyroid hormones
    secretion and metabolic pathway

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004997thyrotropin-releasing hormone receptor activity IEA--
         
    Find genes that share ontologies with TRHR           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TRHR:
     Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Trhr):
     behavior/neurological  growth/size/body  homeostasis/metabolism  reproductive system 

    Find genes that share phenotypes with TRHR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Trhrtm1Hzg for TRHR

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRHR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRHR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRHR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRHR

    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRHR

    Gene Editing
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    OriGene ORF clones in mouse, rat for TRHR
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    GenScript: all cDNA clones in your preferred vector: TRHR (NM_003301)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRHR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRHR

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRHR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRFR_HUMAN, P34981: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8395824
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with TRHR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRHR About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    5Selected targets of GCR alpha
    Selected targets of GCR alpha


    Find genes that share SuperPaths with TRHR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for TRHR
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for TRHR
        Peptide ligand-binding receptors
    G alpha (q) signalling events


    2 Kegg Pathways  (Kegg details for TRHR):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TRHR: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRHR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRHR (P349813 ENSP000003098184) via UniProtKB, MINT, STRING, and/or I2D (see all 126)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRHP203963, ENSP000003034524I2D: score=1 STRING: ENSP00000303452
    ARRB1P494073, ENSP000003771414I2D: score=1 STRING: ENSP00000377141
    ADRA1BENSP000003066624STRING: ENSP00000306662
    ADRA1DENSP000003687664STRING: ENSP00000368766
    ADRBK1ENSP000003122624STRING: ENSP00000312262
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS8395824

    Find genes that share ontologies with TRHR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for TRHR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TaltirelinSynthetic thyrotropin-releasing hormone analog[103300-74-9]

    1 HMDB Compound for TRHR    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 IUPHAR Ligands for TRHR (TRH1 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    MeTRH
    AgonistPartial agonist8.55001013
    taltirelin
    AgonistFull agonist6.523087672

    Selected Novoseek inferred chemical compound relationships for TRHR gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chlordiazepoxide 54.3 1 8584022 (1)
    tripeptide 49 2 8672465 (1), 17123625 (1)
    phosphoinositide 25.2 1 8120038 (1)
    calcium 22.4 9 7501234 (2), 18948837 (1), 18724972 (1), 7525072 (1) (see all 5)
    cycloheximide 20.1 1 8247016 (1)
    inositol 1,4,5 trisphosphate 12.9 1 8045988 (1)
    guanine 12.8 2 8584022 (1), 8247012 (1)
    alanine 11 1 9855624 (1)
    isoproterenol 4.99 1 15673926 (1)
    silver 1.74 1 9003021 (1)



    Find genes that share compounds with TRHR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRHR gene: 
    NM_003301.5  

    Unigene Cluster for TRHR:

    Thyrotropin-releasing hormone receptor
    Hs.3022  [show with all ESTs]
    Unigene Representative Sequence: NM_003301
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000518632 ENST00000311762(uc003ymz.4)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TRHR
      QuantiFast Probe-based Assays in human, mouse, rat TRHR

    Additional mRNA sequence: 

    AY493373.1 BC105045.1 BC113360.1 D16845.1 X72089.1 X75071.1 

    1 DOTS entry:

    DT.208516 

    5 AceView cDNA sequences:

    AY493373 X75071 D16845 X72089 NM_003301 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRHR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCAGAAAT
    TRHR Expression
    About this image


    TRHR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Thalamus
             Substantia Nigra   
     
     Neurons
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Spinal Cord (Nervous System)
    TRHR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRHR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.3022
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TRHR: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TRHR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRHR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRHR gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trhr1 , 5 thyrotropin releasing hormone receptor1, 5 90.48(n)1
    94.64(a)1
      15 (16.82 cM)5
    220451  NM_013696.21  NP_038724.11 
     441961355 
    chicken
    (Gallus gallus)
    Aves TRHR1 thyrotropin-releasing hormone receptor 76.19(n)
    82.65(a)
      395770  NM_204930.1  NP_990261.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRHR6
    thyrotropin-releasing hormone receptor
    82(a)
    1 ↔ 1
    4(10885850-10916556)
    African clawed frog
    (Xenopus laevis)
    Amphibia trhr-A2 thyrotropin-releasing hormone receptor 76.13(n)    AF305620.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trhra1 thyrotropin-releasing hormone receptor a 66.57(n)
    71.23(a)
      558878  XM_682154.4  XP_687246.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta ETHR6
    ETHR
    22(a)
    1 ↔ 1
    3R(17073026-17090856)
    worm
    (Caenorhabditis elegans)
    Secernentea C30F12.63 seven trans-membrane receptor 39(a)   I(6997164-6999907)   --


    ENSEMBL Gene Tree for TRHR (if available)
    TreeFam Gene Tree for TRHR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRHR gene
    GHSR2  NTSR12  GPR392  NMUR12  MLNR2  NMUR22  NTSR22  

    Find genes that share paralogs with TRHR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRHR (see all 617)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219178471,2
    Cpathogenic1110376671(+) AGCCAC/TGAGCA 2 R * stg10--------
    rs58939431,2
    C,F--110097989(+) AAGTTA/-AAAAA 1 -- us2k1 trp33Minor allele frequency- -:0.50NA CSA 6
    rs344432871,2
    C--110098798(+) ATGTATGTG/-  
            
    TGTGT
    1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1997573231,2
    C--110098801(+) TATGTA/GTGTGT 1 -- us2k10--------
    rs748807941,2
    C--110100713(+) TAAAA-/ATAG  
            
    ATAGG
    1 -- int10--------
    rs353744251,2
    C--110106466(+) TTTCA-/TTTTTT 1 -- int13Minor allele frequency- T:0.17NA CSA 6
    rs3738542831,2
    C--110112666(+) CATGG-/TTTTTT 1 -- int10--------
    rs31341041,2
    C,F,A,H--110374592(+) ACAAGC/GCATAg 1 -- us2k117Minor allele frequency- G:0.39NS EA NA WA CSA 795
    rs1397092581,2
    --110374616(+) TAATCC/TCAGCA 1 -- us2k10--------
    rs31100381,2
    C,F,A,H--110374729(-) ACCACG/ACTCAG 1 -- us2k111Minor allele frequency- A:0.48NA WA CSA EA 375

    HapMap Linkage Disequilibrium report for TRHR (110098850 - 110131813 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TRHR:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv270168CNV Insertion20981092
    esv1010309CNV Insertion20482838
    esv272700CNV Insertion20981092
    esv269909CNV Insertion20981092
    nsv891271CNV Gain21882294

    Human Gene Mutation Database (HGMD): TRHR
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 188545    OMIM disorders: --

    6 diseases for TRHR:    
    About MalaCards
    resistance to thyrotropin-releasing hormone syndrome    thyrotropin-releasing hormone resistance, generalized    prolactinoma    hyperthyroidism
    pituitary tumors    acromegaly

    1 disease from the University of Copenhagen DISEASES database for TRHR:
    Hypothyroidism

    Find genes that share disorders with TRHR           About GenesLikeMe

    9 Novoseek inferred disease relationships for TRHR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary adenoma 46.5 10 8396925 (3), 14594554 (1), 9398744 (1), 10199161 (1)
    adenoma 40 20 14599121 (3), 8396925 (1)
    acromegaly 38.5 10 8396925 (3), 14594554 (1), 14599121 (1)
    prolactinoma 37.3 2 14599121 (1)
    hypothyroidism 36.1 9 11857914 (2), 14594554 (1), 9702078 (1), 9141550 (1)
    pituitary tumors 29 6 9398744 (2), 10199161 (1)
    hyperthyroidism 13.3 2 10219918 (2)
    tumors 0 5 8772588 (4), 14594554 (1)
    lymphoma 0 3 15673926 (1), 15209537 (1)

    Genatlas disease: TRHR
    isolated central hypothyroidism with TSH and PRL levels unresponsive to TRH (inactivating mutations of TRHR)

    Genetic Association Database (GAD): TRHR
    Human Genome Epidemiology (HuGE) Navigator: TRHR (4 documents)

    Export disorders for TRHR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRHR gene, integrated from 10 sources (see all 99):
    (articles sorted by number of sources associating them with TRHR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Pituitary adenomas of patients with acromegaly express thyrotropin- releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene. (PubMed id 8396925)1, 2, 9 Yamada M.... Mori M. (Biochem. Biophys. Res. Commun. 1993)
    2. A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor. (PubMed id 8770906)1, 2, 9 Cook J.V.... Eidne K.A. (Endocrinology 1996)
    3. Genome-wide association and replication studies identified TRHR as an important gene for lean body mass. (PubMed id 19268274)1, 4, 9 Liu X.G....Deng H.W. (Am. J. Hum. Genet. 2009)
    4. Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor. (PubMed id 9886052)1, 2, 9 Matre V.... Gautvik K.M. (J. Neurochem. 1999)
    5. Cloning and functional characterisation of the human TRH receptor. (PubMed id 8243797)1, 2, 9 Duthie S.M.... Eidne K.A. (Mol. Cell. Endocrinol. 1993)
    6. Molecular cloning of a functional human thyrotropin-releasing hormone receptor. (PubMed id 8395824)1, 2, 9 Matre V.... Gautvik K.M. (Biochem. Biophys. Res. Commun. 1993)
    7. Genomic organization and promoter function of the human thyrotropin- releasing hormone receptor gene. (PubMed id 8703031)1, 2, 9 Iwasaki T.... Mori M. (J. Biol. Chem. 1996)
    8. Sex differences in environmental and genetic factors for hypertension. (PubMed id 18724972)1, 4, 9 Ruixing Y....Yuming C. (Am. J. Med. 2008)
    9. Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8. (PubMed id 8128317)1, 3, 9 Yamada M....Mori M. (Somat. Cell Mol. Genet. 1993)
    10. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7201 HGNC: 12299 AceView: TRHR Ensembl:ENSG00000174417 euGenes: HUgn7201
    ECgene: TRHR Kegg: 7201 H-InvDB: TRHR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRHR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TRHR gene:
    Search GeneIP for patents involving TRHR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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