Aliases for TRHR Gene
External Ids for TRHR Gene
Previous GeneCards Identifiers for TRHR Gene
This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]
GeneCards Summary for TRHR Gene
TRHR (Thyrotropin-Releasing Hormone Receptor) is a Protein Coding gene. Diseases associated with TRHR include resistance to thyrotropin-releasing hormone syndrome and prolactinoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include thyrotropin-releasing hormone receptor activity. An important paralog of this gene is GPR39.
UniProtKB/Swiss-Prot for TRHR Gene
Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system
Thyrotropin-releasing hormone (TRH) receptors are Gq/11-protein-coupled receptors that promote thyroid-stimulating hormone (TSH) and prolactin (PRL) release. Two TRH receptor subtypes, TRH1 and TRH2, have been identified in rodents, but only the TRH1 receptor has been found in humans. TRH1 is predominantly expressed in the anterior pituitary gland, but is also found at appreciable levels in the brain, pancreas, testis, adrenals and lymphoid organs. The human gene encoding the TRH1 receptor is located on chromosome 8q23.1.