TRHR Gene
protein-coding GIFtS: 61
GCID: GC08P110168
|
|
thyrotropin-releasing hormone receptor
| |
Aliases for TRHR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Thyrotropin-Releasing Hormone Receptor1 2 | | Thyroliberin Receptor2 3 | | TRH-R2 3 |
Export aliases for TRHR gene to outside databasesPrevious GC identifers: GC08P109084 GC08P110167 GC08P109768 GC08P110056 GC08P105422 |
Summaries for TRHR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for TRHR: This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, thisreceptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this genehave been associated with generalized thyrotropin-releasing hormone resistance. (provided by RefSeq, Sep 2011) UniProtKB/Swiss-Prot: TRFR_HUMAN, P34981Function: Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate aphosphatidylinositol-calcium second messenger system
summary
for TRHR: Thyrotropin-releasing hormone (TRH) receptors are Gq/11-protein-coupled receptors that promote thyroid-stimulating hormone (TSH) and prolactin (PRL) release. Two TRH receptor subtypes, TRH1 and TRH2, have been identified in rodents, but only the TRH1 receptor has been found in humans. TRH1 is predominantly expressed in the anterior pituitary gland, but is also found at appreciable levels in the brain, pancreas, testis, adrenals and lymphoid organs. The human gene encoding the TRH1 receptor is located on chromosome 8q23.1. Gene Wiki entry for TRHR (Thyrotropin-releasing hormone receptor)
|
Genomic Views for TRHR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TRHR gene promoter: c-Fos RFX1 AP-1 JunB FosB Fra-1 Evi-1 JunD c-Myb c-Jun Other transcription factors
Search SABiosciences Chromatin IP Primers for TRHR
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRHR |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q23 Ensembl cytogenetic band: 8q23.1 HGNC chromosome: 8TRHR Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P110168: view genomic region
(about GC identifiers)
Start:
|
110,098,850 bp from pter |
End:
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110,131,813 bp from pter |
Size:
|
32,964 bases |
Orientation:
|
plus strand |
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Proteins for TRHR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: TRFR_HUMAN, P34981 (See
protein sequence)Recommended Name: Thyrotropin-releasing hormone receptor Size: 398 amino acids; 45085 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q2M339Explore the universe of human proteins at neXtProt for TRHR: NX_P34981
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P34981 TRHR Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_003292.1 ENSEMBL proteins: ENSP00000430711 ENSP00000309818 Reactome Protein details: P34981 Human Recombinant Protein Products for TRHR:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TRHR for ontologies About GeneDecksing
TRHR Antibody Products: Assay Products for TRHR: |
Protein
Domains / Families for TRHR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRHR for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P34981ProtoNet protein and cluster: P34981 1 Blocks protein family: IPB002120 Thyrotrophin-releasing hormone receptor signature
UniProtKB/Swiss-Prot: TRFR_HUMAN, P34981Similarity: Belongs to the G-protein coupled receptor 1 family |
Function for TRHR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: TRFR_HUMAN, P34981Function: Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate aphosphatidylinositol-calcium second messenger system Genatlas biochemistry entry for TRHR:thyrotropin releasing hormone receptor,neurotransmitter and neuro regulator,involved in the thyroid hormones secretionand metabolic pathway
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004997 | thyrotropin-releasing hormone receptor activity |
IEA | -- | | GO:0042803 | protein homodimerization activity |
-- | -- |
TRHR for ontologies About GeneDecksing
Phenotypes: 1 GenomeRNAi human phenotype for TRHR: 4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Trhr):
TRHR for phenotypes About GeneDecksing
Animal Models: Mouse knock-out Trhrtm1Hzg for TRHR
Clone Products: |  | EMD Millipore Clones for the Expression of TRHR | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRHR (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRHR OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TRHR (NM_003301) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRHR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRHR  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRHR |
|
Pathways & Interactions for TRHR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | G alpha (q) signalling events | | | 4 | Selected targets of GCR-alpha | | | 5 | Calcium signaling pathway | |
Pathway sources See GeneCards unified pathways Show all pathways
1 EMD Millipore Pathway for TRHR
2 BioSystems Pathways for TRHR 
5/8
Reactome Pathways for TRHR (see all 8)
2
Kegg Pathways (Kegg details for TRHR):
TRHR for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRHR
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/126 Interacting proteins for TRHR (P349813 ENSP000003098184) via UniProtKB, MINT, STRING, and/or I2D (see all 126)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor signaling pathway |
TAS | 8395824 | | GO:0007204 | elevation of cytosolic calcium ion concentration |
-- | -- | | GO:0090073 | positive regulation of protein homodimerization activity |
-- | -- |
TRHR for ontologies About GeneDecksing
|
Drugs & Compounds for TRHR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TRHR for compounds About GeneDecksing
Compounds for TRHR available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Taltirelin | Synthetic thyrotropin-releasing hormone (TRH) analog | [103300-74-9] |
1 HMDB Compound for TRHR About this table 10/12 Novoseek chemical compound relationships for TRHR gene (see all 12) About this table
Search CenterWatch for drugs/clinical trials and news about TRHR / TRFR 
|
Transcripts for TRHR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for TRHR gene: NM_003301.5 Unigene Cluster for TRHR: Thyrotropin-releasing hormone receptor Hs.3022 [show with all ESTs]Unigene Representative Sequence: NM_0033012 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000518632 ENST00000311762(uc003ymz.4)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRHR (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRHR OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TRHR (NM_003301) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRHR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRHR  |
Additional cDNA sequence: AY493373.1 BC105045.1 BC113360.1 D16845.1 X72089.1 X75071.1 1 DOTS entry: DT.208516 5 AceView cDNA sequences: D16845 X75071 AY493373 X72089 NM_003301 GeneLoc Exon Structure
|
Expression for TRHR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRHR expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TCCCAGAAAT
 About this image See TRHR Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TRHR
SOURCE GeneReport for Unigene cluster: Hs.3022 SABiosciences Expression via Pathway-Focused PCR Arrays including TRHR:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRHR Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRHR | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRHR | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRHR | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRHR |
Orthologs for TRHR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TRHR gene from 6/17 species (see all 17) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
TRHR1 |
thyrotropin-releasing hormone receptor |
76.19(n) 82.65(a) |
  |
395770 NM_204930.1 NP_990261.1 |
lizard (Anolis carolinensis) |
Reptilia |
TRHR6 |
-- |
80(a) |
1 ↔ 1 |
4(10885449-10915045) |
African clawed frog (Xenopus laevis) |
Amphibia |
trhr-A2 |
thyrotropin-releasing hormone receptor |
76.13(n) |
  |
AF305620.1 |
zebrafish (Danio rerio) |
Actinopterygii |
LOC5588781 |
thyrotropin-releasing hormone receptor-like |
66.57(n) 71.23(a) |
  |
558878 XM_682154.3 XP_687246.3 |
fruit fly (Drosophila melanogaster) |
Insecta |
ETHR1 |
CG5911-PA |
45.67(n) 35.99(a) |
  |
42523 NM_142703.2 NP_650960.2 |
worm (Caenorhabditis elegans) |
Secernentea |
C30F12.63 |
seven trans-membrane receptor |
39(a) |
  |
I(6997164-6999907) -- |
ENSEMBL Gene Tree for TRHR (if available) TreeFam Gene Tree for TRHR (if available)  |
Paralogs for TRHR gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for TRHR gene
- NTSR12 GPR392 GHSR2 NMUR12 MLNR2 NMUR22 NTSR22
TRHR for paralogs About GeneDecksing
|
Genomic Variants for TRHR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 8 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for TRHR (110098850 - 110131813 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TRHR: -- Human Gene Mutation Database (HGMD): TRHR
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRHR |
|
Disorders
/ Diseases for TRHR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRHR for disorders About GeneDecksing
OMIM gene information: 188545
OMIM disorders: --
15 diseases for TRHR: About MalaCardsthyrotropin-releasing hormone resistance thyrotropin-releasing hormone resistance, generalized thyroiditis pituitary adenoma prolactinoma pituitary tumor acromegaly hyperthyroidism hypothyroidism essential hypertension adenoma aldosteronism hypertension lung cancer pancreatitis
9 Novoseek disease relationships for TRHR gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| pituitary adenoma |
46.5 |
10 |
8396925 (3), 14594554 (1), 9398744 (1), 10199161 (1) |
| adenoma |
40 |
20 |
14599121 (3), 8396925 (1) |
| acromegaly |
38.5 |
10 |
8396925 (3), 14594554 (1), 14599121 (1) |
| prolactinoma |
37.3 |
2 |
14599121 (1) |
| hypothyroidism |
36.1 |
9 |
11857914 (2), 14594554 (1), 9702078 (1), 9141550 (1) |
| pituitary tumors |
29 |
6 |
9398744 (2), 10199161 (1) |
| hyperthyroidism |
13.3 |
2 |
10219918 (2) |
| tumors |
0 |
5 |
8772588 (4), 14594554 (1) |
| lymphoma |
0 |
3 |
15673926 (1), 15209537 (1) |
Genatlas disease: TRHR isolated central hypothyroidism with TSH and PRL levels unresponsive to TRH (inactivating mutations of TRHR) Genetic Association Database (GAD): TRHR Human Genome Epidemiology (HuGE) Navigator: TRHR (4 documents) Export disorders for TRHR gene to outside databases
|
Publications for TRHR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRHR gene, integrated from 9 sources (see all 97): (articles sorted by number of sources associating them with TRHR) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Pituitary adenomas of patients with acromegaly express thyrotropin- releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene. (PubMed id 8396925)1, 2, 9 Yamada M.... Mori M. (1993)
- A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor. (PubMed id 8770906)1, 2, 9 Cook J.V.... Eidne K.A. (1996)
- Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor. (PubMed id 9886052)1, 2, 9 Matre V.... Gautvik K.M. (1999)
- Cloning and functional characterisation of the human TRH receptor. (PubMed id 8243797)1, 2, 9 Duthie S.M.... Eidne K.A. (1993)
- Molecular cloning of a functional human thyrotropin-releasing hormone receptor. (PubMed id 8395824)1, 2, 9 Matre V.... Gautvik K.M. (1993)
- Genomic organization and promoter function of the human thyrotropin- releasing hormone receptor gene. (PubMed id 8703031)1, 2, 9 Iwasaki T.... Mori M. (1996)
- Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8. (PubMed id 8128317)1, 3, 9 Yamada M....Mori M. (1993)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Molecular cloning and functional expression of a human thyrotropin- releasing hormone (TRH) receptor gene. (PubMed id 7918619)1, 2 Hinuma S.... Onda H. (1994)
- Thyrotropin-releasing hormone receptor (TRHR) gene is associated with essential hypertension. (PubMed id 11566956)4, 9 Garcia S.I....Pirola C.J. (2001)
|
External Searches for TRHR gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TRHR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRHR gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRHR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for TRHR | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TRHR gene: Search GeneIP for patents involving TRHR
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for TRHR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for TRHR | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRHR | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRHR | | OriGene Protein Over-expression Lysate for TRHR | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for TRHR | | Browse 3'-UTR reporter clones for miRNA target validation | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRHR | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRHR | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for TRHR | | OriGene Custom Protein Services for TRHR | | OriGene Custom Immunoassay Development | | |
| |  |
 |
| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRHR | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRHR | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRHR | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRHR | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRHR | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRHR |
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 |  |  |  | |
| | | Tocris compounds for TRHR |
| |  |  |  |  | | | | |
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 |
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 | | TRHR Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRHR |
|  |  |  |  | | | ThermoFisher Antibodies for TRHR |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRHR |
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