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TRHDE Gene

protein-coding   GIFtS: 55
GCID: GC12P072453

Thyrotropin-Releasing Hormone Degrading Enzyme

  See TRHDE-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thyrotropin-Releasing Hormone Degrading Enzyme1 2     PGPEP22
TRH-Specific Aminopeptidase1 2 3     thyroliberinase2
Pyroglutamyl-Peptidase II1 2 3     Thyrotropin-Releasing Hormone Degrading Ectoenzyme2
Pyroglutamyl Aminopeptidase II1 2     Thyrotropin-Releasing Hormone-Degrading Ectoenzyme2
PAP-II2 3     EC 3.4.19.63
TRH-DE2 3     Thyroliberinase3
TRH-Degrading Ectoenzyme2 3     

External Ids:    HGNC: 307481   Entrez Gene: 299532   Ensembl: ENSG000000726577   OMIM: 6069505   UniProtKB: Q9UKU63   

Export aliases for TRHDE gene to outside databases

Previous GC identifers: GC12P072618 GC12P070952 GC12P069714


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRHDE Gene:
This gene encodes a member of the peptidase M1 family. The encoded protein is an extracellular peptidase that
specifically cleaves and inactivates the neuropeptide thyrotropin-releasing hormone.(provided by RefSeq, Dec
2008)

GeneCards Summary for TRHDE Gene:
TRHDE (thyrotropin-releasing hormone degrading enzyme) is a protein-coding gene. Diseases associated with TRHDE include good syndrome. GO annotations related to this gene include metallopeptidase activity and aminopeptidase activity. An important paralog of this gene is LNPEP.

UniProtKB/Swiss-Prot: TRHDE_HUMAN, Q9UKU6
Function: Specific inactivation of TRH after its release




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRHDE gene promoter:
         USF1   AML1a   USF2   CUTL1   USF-1:USF-2   HNF-1A   Gfi-1   USF-1   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRHDE promoter sequence
   Search Chromatin IP Primers for TRHDE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRHDE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15-q21   Ensembl cytogenetic band:  12q21.1   HGNC cytogenetic band: 12q15-q21

TRHDE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRHDE gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P072453:  view genomic region     (about GC identifiers)

Start:
72,481,046 bp from pter      End:
73,059,422 bp from pter
Size:
578,377 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TRHDE_HUMAN, Q9UKU6 (See protein sequence)
Recommended Name: Thyrotropin-releasing hormone-degrading ectoenzyme  
Size: 1024 amino acids; 117000 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Homodimer; disulfide-linked (By similarity)
Secondary accessions: A5PL19 Q6UWJ4

Explore the universe of human proteins at neXtProt for TRHDE: NX_Q9UKU6

Explore proteomics data for TRHDE at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn89, Asn160, Asn175, Asn222, Asn338, Asn605, Asn634, Asn649, Asn663, Asn684,
                                 Asn800, Asn906
  • Modification sites at PhosphoSitePlus

  • See TRHDE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037513.1  
    ENSEMBL proteins: 
     ENSP00000261180   ENSP00000447822  

    TRHDE Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TRHDE

     
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    antibodies-online peptides for TRHDE

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    antibodies-online antibodies for TRHDE (9 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: TRH-specific aminopeptidase
    Aminopeptidases

    4 InterPro protein domains:
     IPR014782 Peptidase_M1_N
     IPR024571 ERAP1-like_C_dom
     IPR001930 Peptidase_M1
     IPR015570 Peptidase_M1_TRH-DE

    Graphical View of Domain Structure for InterPro Entry Q9UKU6

    ProtoNet protein and cluster: Q9UKU6

    1 Blocks protein domain: IPB001930 Membrane alanyl dipeptidase (M1) family signature

    UniProtKB/Swiss-Prot: TRHDE_HUMAN, Q9UKU6
    Similarity: Belongs to the peptidase M1 family


    Find genes that share domains with TRHDE           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRHDE_HUMAN, Q9UKU6
    Function: Specific inactivation of TRH after its release
    Catalytic activity: Release of the N-terminal pyroglutamyl group from pGlu- -His-Xaa tripeptides and pGlu-
    -His-Xaa-Gly tetrapeptides

         Genatlas biochemistry entry for TRHDE:
    TRH (thyrotropin releasing hormone) degrading ectoenzyme specific neuropeptidase,restrictively expressed in tissue
    with highest expression in brain

         Enzyme Number (IUBMB): EC 3.4.19.61

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IEA--
    GO:0008237metallopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with TRHDE           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Trhde):
     no phenotypic analysis 

    Find genes that share phenotypes with TRHDE           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Trhdetm1Lex for TRHDE

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRHDE
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    Selected qRT-PCR Assays for microRNAs that regulate TRHDE (see all 62):
    hsa-miR-302d hsa-miR-520e hsa-miR-4307 hsa-let-7d hsa-miR-200a hsa-let-7a-2* hsa-miR-219-5p hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidTRHDE 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRHDE

    Gene Editing
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    Sino Biological Human cDNA Clone for TRHDE
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRHDE

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRHDE


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRHDE_HUMAN, Q9UKU6: Membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    endoplasmic reticulum1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS10491199

    Find genes that share ontologies with TRHDE           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRHDE
    Interactions:

        GeneGlobe Interaction Network for TRHDE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for TRHDE (Q9UKU63 ENSP000002611804) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    REG3AQ061413, ENSP000003043114I2D: score=1 STRING: ENSP00000304311
    SCHIP1Q9P0W53I2D: score=1 
    AKT1ENSP000002702024STRING: ENSP00000270202
    ORC2ENSP000002342964STRING: ENSP00000234296
    RAD1ENSP000003408794STRING: ENSP00000340879
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007165signal transduction TAS10491199
    GO:0007267cell-cell signaling TAS10491199

    Find genes that share ontologies with TRHDE           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRHDE

    4 Novoseek inferred chemical compound relationships for TRHDE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tripeptide 49.8 1 7714073 (1)
    1,10-phenanthroline 48.4 1 15305021 (1)
    sphingosine 47.7 1 1979029 (1)
    12-o-tetradecanoylphorbol 13-acetate 41.2 3 1672274 (2)



    Find genes that share compounds with TRHDE           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRHDE gene: 
    NM_013381.2  

    Unigene Cluster for TRHDE:

    Thyrotropin-releasing hormone degrading enzyme
    Hs.199814  [show with all ESTs]
    Unigene Representative Sequence: AF126372
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000548156 ENST00000261180(uc001sxa.3) ENST00000547300 ENST00000552503
    ENST00000549138 ENST00000549401 ENST00000549922
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TRHDE (see all 62):
    hsa-miR-302d hsa-miR-520e hsa-miR-4307 hsa-let-7d hsa-miR-200a hsa-let-7a-2* hsa-miR-219-5p hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidTRHDE 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRHDE
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    GenScript: all cDNA clones in your preferred vector: TRHDE (NM_013381)
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      QuantiFast Probe-based Assays in human, mouse, rat TRHDE

    Additional mRNA sequence: 

    AF126372.1 AK026034.1 AY358765.1 BC023230.1 BC142706.1 BC150181.1 

    3 DOTS entries:

    DT.407501  DT.95365405  DT.91997188 

    Selected AceView cDNA sequences (see all 40):

    AK026034 BX283191 BU193089 AI002990 AY358765 AA555212 AL700556 BI826481 
    BC023230 T16331 BP349248 BF790534 NM_013381 CD624923 CD624921 AL706544 
    AI631882 BX498461 BU180545 CD624938 CD624927 AA668253 AF126372 CD624919 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRHDE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGATGAATA
    TRHDE Expression
    About this image


    TRHDE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
    TRHDE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRHDE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.199814

    UniProtKB/Swiss-Prot: TRHDE_HUMAN, Q9UKU6
    Tissue specificity: Predominantly expressed in brain

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRHDE gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trhde1 , 5 TRH-degrading enzyme1, 5 90.14(n)1
    95.9(a)1
      10 (61.59 cM)5
    2375531  NM_146241.21  NP_666353.11 
     1143988235 
    chicken
    (Gallus gallus)
    Aves TRHDE1 thyrotropin-releasing hormone degrading enzyme 83.97(n)
    90.33(a)
      427868  XM_425442.3  XP_425442.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    82(a)
    65(a)
    1 ↔ many
    1 ↔ many
    5(38803957-39133264)
    5(38803505-38815575)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia trhde1 thyrotropin-releasing hormone degrading enzyme 74.01(n)
    78.78(a)
      100489066  XM_002939942.2  XP_002939988.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5624091 thyrotropin-releasing hormone-degrading ectoenzyme-like 67.61(n)
    68.02(a)
      562409  XM_685797.5  XP_690889.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG119513 membrane alanyl aminopeptidase 34(a)
    (best of 11)
      99A4   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y67D8C.93   -- 33(a)
    (best of 7)
      IV(3077664-3086852)   --


    ENSEMBL Gene Tree for TRHDE (if available)
    TreeFam Gene Tree for TRHDE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRHDE gene
    LNPEP2  ENPEP2  ANPEP2  LOC1010602122  ERAP12  NPEPPS2  AQPEP2  ERAP22  
    11 SIMAP similar genes for TRHDE using alignment to 2 protein entries:     TRHDE_HUMAN (see all proteins):
    CD13    LOC100510707    NPEPPSL1    LNPEP    AQPEP    FLJ90650
    ERAP2    NPEPPS    ANPEP    ENPEP    ERAP1

    Find genes that share paralogs with TRHDE           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRHDE (see all 6811)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs589123451,2
    C--69942873(+) TTTTT-/T/TT  
            
    AAGTT
    1 -- int11NA 2
    rs343638321,2
    C--72587128(+) CCTTT-/TAGTTTG 1 -- int10--------
    rs124246441,2
    C,F,H--72669295(+) ATACGG/AGGGAA 1 -- int1 trp313Minor allele frequency- A:0.05NS EA NA 1678
    rs1503988041,2
    --72669305(+) AAGGCA/CTAGAA 1 -- int10--------
    rs107849601,2
    C,F,A,H--72669426(+) AAAAAC/TCCTGT 1 -- int115Minor allele frequency- T:0.28NS EA NA WA CSA 792
    rs1856690311,2
    --72669478(+) GTTTTG/TGTCAA 1 -- int10--------
    rs79793781,2
    C,F,A,H--72669533(+) CTTGAA/GCCGTA 1 -- int126Minor allele frequency- G:0.18NA NS EA WA CSA 2493
    rs1381668331,2
    C--72669562(+) TAGTGC/TGTATT 1 -- int10--------
    rs731373401,2
    C--72669774(+) TTATTA/GGAGTA 1 -- int10--------
    rs1145484631,2
    F--72670199(+) GTGCAG/ATCCAC 1 -- int11Minor allele frequency- A:0.09WA 118

    HapMap Linkage Disequilibrium report for TRHDE (72481046 - 72731046 bp, first 250kb of TRHDE)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TRHDE (see all 31):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1942657CNV Deletion18987734
    esv2746054CNV Deletion23290073
    esv1226093CNV Deletion17803354
    esv3786CNV Deletion18987735
    esv2746055CNV Deletion23290073
    esv2746056CNV Deletion23290073
    esv2746057CNV Deletion23290073
    esv2666571CNV Deletion23128226
    esv987864CNV Deletion20482838
    esv2746052CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606950    OMIM disorders: --

    1 disease for TRHDE:    
    About MalaCards
    good syndrome

    2 diseases from the University of Copenhagen DISEASES database for TRHDE:
    Good syndrome     Cervical cancer

    Find genes that share disorders with TRHDE           About GenesLikeMe

    1 Novoseek inferred disease relationship for TRHDE gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 33.3 3 1672274 (2), 1979029 (1)

    Genetic Association Database (GAD): TRHDE
    Human Genome Epidemiology (HuGE) Navigator: TRHDE (6 documents)

    Export disorders for TRHDE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TRHDE gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with TRHDE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human TRH-degrading ectoenzyme cDNA cloning, functional expression, genomic structure and chromosomal assignment. (PubMed id 10491199)1, 2, 3, 9 Schomburg L....Bauer K. (Eur. J. Biochem. 1999)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    3. Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility loci. (PubMed id 21452313)1, 4 Freudenberg J....Bae S.C. (Arthritis Rheum. 2011)
    4. Chemerin, a novel adipokine in the regulation of angiogenesis. (PubMed id 20237162)1, 4 Bozaoglu K....Jowett J.B. (J. Clin. Endocrinol. Metab. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. (PubMed id 23934736)1 Yu B....Boerwinkle E. (Genet. Epidemiol. 2013)
    8. Genome-wide association study identifies genetic loci associated with body mass index and high density lipoprotein-cholesterol levels during psychopharmacological treatment - a cross-sectional naturalistic study. (PubMed id 22417934)4 Athanasiu L....Djurovic S. (Psychiatry Res 2012)
    9. Vimentin is a novel AKT1 target mediating motility and invasion. (PubMed id 20856200)1 Zhu Q.S....Lev D. (Oncogene 2011)
    10. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 29953 HGNC: 30748 AceView: TRHDE Ensembl:ENSG00000072657 euGenes: HUgn29953
    ECgene: TRHDE H-InvDB: TRHDE

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TRHDE Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TRHDE gene:
    Search GeneIP for patents involving TRHDE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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