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Aliases for TRHDE Gene

Aliases for TRHDE Gene

  • Thyrotropin-Releasing Hormone Degrading Enzyme 2 3
  • TRH-Specific Aminopeptidase 2 3 4
  • Pyroglutamyl-Peptidase II 2 3 4
  • Pyroglutamyl Aminopeptidase II 2 3
  • TRH-Degrading Ectoenzyme 3 4
  • Thyroliberinase 3 4
  • PAP-II 3 4
  • TRH-DE 3 4
  • Thyrotropin-Releasing Hormone Degrading Ectoenzyme 3
  • EC 4
  • PGPEP2 3

External Ids for TRHDE Gene

Previous GeneCards Identifiers for TRHDE Gene

  • GC12P072453
  • GC12P072618
  • GC12P070952
  • GC12P069714

Summaries for TRHDE Gene

Entrez Gene Summary for TRHDE Gene

  • This gene encodes a member of the peptidase M1 family. The encoded protein is an extracellular peptidase that specifically cleaves and inactivates the neuropeptide thyrotropin-releasing hormone.[provided by RefSeq, Dec 2008]

GeneCards Summary for TRHDE Gene

TRHDE (Thyrotropin-Releasing Hormone Degrading Enzyme) is a Protein Coding gene. Diseases associated with TRHDE include endocervicitis. GO annotations related to this gene include metallopeptidase activity and aminopeptidase activity. An important paralog of this gene is ERAP1.

UniProtKB/Swiss-Prot for TRHDE Gene

  • Specific inactivation of TRH after its release

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRHDE Gene

Genomics for TRHDE Gene

Regulatory Elements for TRHDE Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRHDE Gene

72,087,266 bp from pter
72,670,757 bp from pter
583,492 bases
Plus strand

Genomic View for TRHDE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for TRHDE Gene

Proteins for TRHDE Gene

  • Protein details for TRHDE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thyrotropin-releasing hormone-degrading ectoenzyme
    Protein Accession:
    Secondary Accessions:
    • A5PL19
    • Q6UWJ4

    Protein attributes for TRHDE Gene

    1024 amino acids
    Molecular mass:
    117000 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Homodimer; disulfide-linked.

neXtProt entry for TRHDE Gene

Proteomics data for TRHDE Gene at MOPED

Post-translational modifications for TRHDE Gene

  • Glycosylation at Asn 89, Asn 160, Asn 175, Asn 222, Asn 338, Asn 605, Asn 634, Asn 649, Asn 663, Asn 684, Asn 800, and Asn 906
  • Modification sites at PhosphoSitePlus

Other Protein References for TRHDE Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TRHDE (TRH-degrading Ectoenzyme/TRHDE)

No data available for DME Specific Peptides for TRHDE Gene

Domains & Families for TRHDE Gene

Gene Families for TRHDE Gene

Suggested Antigen Peptide Sequences for TRHDE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M1 family.
  • Belongs to the peptidase M1 family.
genes like me logo Genes that share domains with TRHDE: view

Function for TRHDE Gene

Molecular function for TRHDE Gene

GENATLAS Biochemistry:
TRH (thyrotropin releasing hormone) degrading ectoenzyme specific neuropeptidase,restrictively expressed in tissue with highest expression in brain
UniProtKB/Swiss-Prot CatalyticActivity:
Release of the N-terminal pyroglutamyl group from pGlu- -His-Xaa tripeptides and pGlu- -His-Xaa-Gly tetrapeptides
UniProtKB/Swiss-Prot Function:
Specific inactivation of TRH after its release

Enzyme Numbers (IUBMB) for TRHDE Gene

Gene Ontology (GO) - Molecular Function for TRHDE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity TAS 10491199
GO:0008237 metallopeptidase activity --
GO:0008270 zinc ion binding IBA --
GO:0042277 peptide binding IBA --
GO:0070006 metalloaminopeptidase activity IBA --
genes like me logo Genes that share ontologies with TRHDE: view

Phenotypes for TRHDE Gene

MGI mutant phenotypes for TRHDE:
inferred from 1 alleles
GenomeRNAi human phenotypes for TRHDE:
genes like me logo Genes that share phenotypes with TRHDE: view

Animal Model Products

miRNA for TRHDE Gene

miRTarBase miRNAs that target TRHDE

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRHDE

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TRHDE Gene

Localization for TRHDE Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRHDE Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for TRHDE Gene COMPARTMENTS Subcellular localization image for TRHDE gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 1

Gene Ontology (GO) - Cellular Components for TRHDE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005887 integral component of plasma membrane TAS 10491199
GO:0016020 membrane --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TRHDE: view

Pathways & Interactions for TRHDE Gene

SuperPathways for TRHDE Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRHDE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA --
GO:0007165 signal transduction TAS 10491199
GO:0007267 cell-cell signaling TAS 10491199
GO:0008217 regulation of blood pressure IBA --
GO:0043171 peptide catabolic process IBA --
genes like me logo Genes that share ontologies with TRHDE: view

No data available for Pathways by source and SIGNOR curated interactions for TRHDE Gene

Drugs & Compounds for TRHDE Gene

(2) Drugs for TRHDE Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1,10-phenanthroline Experimental Pharma 0
Sphingosine Experimental Pharma 0

(2) Additional Compounds for TRHDE Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
12-O-Tetradecanoylphorbol 13-acetate
genes like me logo Genes that share compounds with TRHDE: view

Transcripts for TRHDE Gene

Unigene Clusters for TRHDE Gene

Thyrotropin-releasing hormone degrading enzyme:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRHDE

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRHDE Gene

No ASD Table

Relevant External Links for TRHDE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRHDE Gene

mRNA expression in normal human tissues for TRHDE Gene

mRNA differential expression in normal tissues according to GTEx for TRHDE Gene

This gene is overexpressed in Pancreas (x4.9).

Protein differential expression in normal tissues from HIPED for TRHDE Gene

This gene is overexpressed in Urine (64.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRHDE Gene

SOURCE GeneReport for Unigene cluster for TRHDE Gene Hs.199814

mRNA Expression by UniProt/SwissProt for TRHDE Gene

Tissue specificity: Predominantly expressed in brain
genes like me logo Genes that share expression patterns with TRHDE: view

Protein tissue co-expression partners for TRHDE Gene

Primer Products

In Situ Assay Products

Orthologs for TRHDE Gene

This gene was present in the common ancestor of animals.

Orthologs for TRHDE Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRHDE 35
  • 92.7 (n)
  • 95.89 (a)
  • 96 (a)
(Canis familiaris)
Mammalia TRHDE 35
  • 90.6 (n)
  • 93.86 (a)
  • 98 (a)
(Mus musculus)
Mammalia Trhde 35
  • 90.14 (n)
  • 95.9 (a)
Trhde 16
Trhde 36
  • 96 (a)
(Pan troglodytes)
Mammalia TRHDE 35
  • 98.83 (n)
  • 98.76 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Trhde 35
  • 90.2 (n)
  • 95.8 (a)
(Monodelphis domestica)
Mammalia TRHDE 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia TRHDE 36
  • 91 (a)
(Gallus gallus)
Aves TRHDE 35
  • 83.97 (n)
  • 90.33 (a)
  • 90 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
-- 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trhde 35
  • 74.01 (n)
  • 78.78 (a)
(Danio rerio)
Actinopterygii LOC562409 35
  • 67.61 (n)
  • 68.02 (a)
TRHDE (1 of 2) 36
  • 68 (a)
TRHDE (2 of 2) 36
  • 67 (a)
fruit fly
(Drosophila melanogaster)
Insecta BG:DS00365.1 37
  • 27 (a)
CG11951 37
  • 34 (a)
CG14516 37
  • 32 (a)
CG2111 37
  • 29 (a)
CG3502 37
  • 27 (a)
CG4467 37
  • 25 (a)
CG5849 37
  • 27 (a)
CG6071 37
  • 24 (a)
CG9806 37
  • 27 (a)
sda 37
  • 29 (a)
SP1029 37
  • 30 (a)
CG4467 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea AC3.5 37
  • 22 (a)
R03G8.4 37
  • 28 (a)
R03G8.6 37
  • 27 (a)
T07F10.1 37
  • 29 (a)
T16G12.1 37
  • 26 (a)
Y42A5A.1 37
  • 26 (a)
Y67D8C.9 37
  • 33 (a)
F49B2.6 36
  • 25 (a)
Species with no ortholog for TRHDE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRHDE Gene

Gene Tree for TRHDE (if available)
Gene Tree for TRHDE (if available)

Paralogs for TRHDE Gene

Paralogs for TRHDE Gene

(11) SIMAP similar genes for TRHDE Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TRHDE: view

Variants for TRHDE Gene

Sequence variations from dbSNP and Humsavar for TRHDE Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs177616 -- 72,613,800(+) TTTCT(C/G)TGTGC intron-variant
rs184916 -- 72,629,678(+) TTGTA(A/C)TAAGA intron-variant
rs186253 -- 72,617,482(-) AAGTG(C/G)ACAGG intron-variant
rs191028 -- 72,612,960(+) GAGAA(A/G)AAATG intron-variant
rs192782 -- 72,617,454(-) TTCAT(C/T)TTCGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRHDE Gene

Variant ID Type Subtype PubMed ID
esv2422452 CNV Duplication 17116639
nsv899257 CNV Loss 21882294
nsv832452 CNV Gain 17160897
nsv899258 CNV Gain 21882294
nsv469465 CNV Gain 19166990
nsv771 CNV Insertion 18451855
esv269831 CNV Insertion 20981092
esv274378 CNV Insertion 20981092
esv2746052 CNV Deletion 23290073
esv2166520 CNV Deletion 18987734
esv2666571 CNV Deletion 23128226
esv2746054 CNV Deletion 23290073
esv1226093 CNV Deletion 17803354
esv23503 CNV Loss 19812545
esv1942657 CNV Deletion 18987734
esv2746055 CNV Deletion 23290073
nsv832453 CNV Gain+Loss 17160897
nsv772 CNV Loss 18451855
esv2676770 CNV Deletion 23128226
nsv521839 CNV Loss 19592680
nsv469466 CNV Loss 19166990
nsv818925 CNV Loss 17921354
nsv899259 CNV Loss 21882294
nsv899260 CNV Loss 21882294
nsv832454 CNV Gain 17160897
esv2746056 CNV Deletion 23290073
esv3786 CNV Deletion 18987735
esv987864 CNV Deletion 20482838
esv2661304 CNV Deletion 23128226
esv2746057 CNV Deletion 23290073
dgv520e1 CNV Complex 17122850

Variation tolerance for TRHDE Gene

Residual Variation Intolerance Score: 2.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRHDE Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRHDE Gene

Disorders for TRHDE Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRHDE Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • endocervicitis unspecified
- elite association
Search TRHDE in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRHDE

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRHDE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRHDE Gene

Publications for TRHDE Gene

  1. Human TRH-degrading ectoenzyme cDNA cloning, functional expression, genomic structure and chromosomal assignment. (PMID: 10491199) Schomburg L. … Bauer K. (Eur. J. Biochem. 1999) 2 23 67
  2. Anterior pituitary pyroglutamyl peptidase II activity controls TRH-induced prolactin release. (PMID: 18703099) Cruz R. … Charli J.L. (Peptides 2008) 23 67
  3. Synthesis of the phosphinic analogue of thyrotropin releasing hormone. (PMID: 18826326) Matziari M. … Yiotakis A. (J. Org. Chem. 2008) 23 67
  4. Endothelin-3 growth factor levels decreased in cervical cancer compared with normal cervical epithelial cells. (PMID: 17445867) Sun d.e. .J. … Deisseroth A. (Hum. Pathol. 2007) 23 67
  5. Homology modeling and site-directed mutagenesis of pyroglutamyl peptidase II. Insights into omega-versus aminopeptidase specificity in the M1 family. (PMID: 16611635) ChA!vez-GutiAcrrez L. … Charli J.L. (J. Biol. Chem. 2006) 23 67

Products for TRHDE Gene

Sources for TRHDE Gene

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