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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRHDE Gene

protein-coding   GIFtS: 54
GCID: GC12P072453

Thyrotropin-Releasing Hormone Degrading Enzyme

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Thyrotropin-Releasing Hormone Degrading Enzyme1 2     PGPEP22
TRH-Specific Aminopeptidase1 2 3     thyroliberinase2
Pyroglutamyl-Peptidase II1 2 3     Thyrotropin-Releasing Hormone Degrading Ectoenzyme2
Pyroglutamyl Aminopeptidase II1 2     Thyrotropin-Releasing Hormone-Degrading Ectoenzyme2
PAP-II2 3     EC 3.4.19.63
TRH-DE2 3     Thyroliberinase3
TRH-Degrading Ectoenzyme2 3     

External Ids:    HGNC: 307481   Entrez Gene: 299532   Ensembl: ENSG000000726577   OMIM: 6069505   UniProtKB: Q9UKU63   

Export aliases for TRHDE gene to outside databases

Previous GC identifers: GC12P072618 GC12P070952 GC12P069714


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRHDE Gene:
This gene encodes a member of the peptidase M1 family. The encoded protein is an extracellular peptidase that
specifically cleaves and inactivates the neuropeptide thyrotropin-releasing hormone.(provided by RefSeq, Dec
2008)

GeneCards Summary for TRHDE Gene: 
TRHDE (thyrotropin-releasing hormone degrading enzyme) is a protein-coding gene. Diseases associated with TRHDE include good syndrome, and adenohypophysitis. GO annotations related to this gene include aminopeptidase activity and metalloendopeptidase activity. An important paralog of this gene is LNPEP.

UniProtKB/Swiss-Prot: TRHDE_HUMAN, Q9UKU6
Function: Specific inactivation of TRH after its release




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRHDE gene promoter:
         USF1   AML1a   USF2   CUTL1   USF-1:USF-2   HNF-1A   Gfi-1   USF-1   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRHDE promoter sequence
   Search SABiosciences Chromatin IP Primers for TRHDE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRHDE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15-q21   Ensembl cytogenetic band:  12q21.1   HGNC cytogenetic band: 12q15-q21

TRHDE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRHDE gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P072453:  view genomic region     (about GC identifiers)

Start:
72,481,046 bp from pter      End:
73,059,422 bp from pter
Size:
578,377 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRHDE_HUMAN, Q9UKU6 (See protein sequence)
Recommended Name: Thyrotropin-releasing hormone-degrading ectoenzyme  
Size: 1024 amino acids; 117000 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Homodimer; disulfide-linked (By similarity)
Subcellular location: Membrane; Single-pass type II membrane protein
Secondary accessions: A5PL19 Q6UWJ4

Explore the universe of human proteins at neXtProt for TRHDE: NX_Q9UKU6

Explore proteomics data for TRHDE at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UKU6

  • TRHDE Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRHDE Protein Expression
    REFSEQ proteins: NP_037513.1  
    ENSEMBL proteins: 
     ENSP00000261180   ENSP00000447822  

    Human Recombinant Protein Products for TRHDE: 
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    Novus Biologicals TRHDE Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRHDE 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS10491199

    TRHDE for ontologies           About GeneDecksing



    TRHDE Antibody Products: 
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    Assay Products for TRHDE: 
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    Cloud-Clone Corp. CLIAs for TRHDE


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: TRH-specific aminopeptidase 
    Aminopeptidases

    4 InterPro protein domains:
     IPR014782 Peptidase_M1_N
     IPR024571 DUF3358
     IPR001930 Peptidase_M1
     IPR015570 Peptidase_M1_TRH-DE

    Graphical View of Domain Structure for InterPro Entry Q9UKU6

    ProtoNet protein and cluster: Q9UKU6

    1 Blocks protein domain: IPB001930 Membrane alanyl dipeptidase (M1) family signature

    UniProtKB/Swiss-Prot: TRHDE_HUMAN, Q9UKU6
    Similarity: Belongs to the peptidase M1 family


    TRHDE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRHDE_HUMAN, Q9UKU6
    Function: Specific inactivation of TRH after its release
    Catalytic activity: Release of the N-terminal pyroglutamyl group from pGlu- -His-Xaa tripeptides and pGlu-
    -His-Xaa-Gly tetrapeptides

         Genatlas biochemistry entry for TRHDE:
    TRH (thyrotropin releasing hormone) degrading ectoenzyme specific neuropeptidase,restrictively expressed in tissue
    with highest expression in brain

         Enzyme Number (IUBMB): EC 3.4.19.61

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IEA--
    GO:0008237metallopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    TRHDE for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Trhde):
     no phenotypic analysis 

    TRHDE for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Trhdetm1Lex for TRHDE

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRHDE 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRHDE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRHDE 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRHDE 

    miRNA
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    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate TRHDE (see all 62):
    hsa-miR-302d hsa-miR-520e hsa-miR-4307 hsa-let-7d hsa-miR-200a hsa-let-7a-2* hsa-miR-219-5p hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidTRHDE 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TRHDE (see all 7)
    OriGene ORF clones in mouse, rat for TRHDE
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                         Customized lentivirus expression plasmids for stable overexpression of TRHDE 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRHDE


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRHDE

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for TRHDE (Q9UKU63 ENSP000002611804) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    REG3AQ061413, ENSP000003043114I2D: score=1 STRING: ENSP00000304311
    SCHIP1Q9P0W53I2D: score=1 
    AKT1ENSP000002702024STRING: ENSP00000270202
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0007165signal transduction TAS10491199
    GO:0007267cell-cell signaling TAS10491199

    TRHDE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRHDE for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRHDE

    4 Novoseek inferred chemical compound relationships for TRHDE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tripeptide 49.8 1 7714073 (1)
    1,10-phenanthroline 48.4 1 15305021 (1)
    sphingosine 47.7 1 1979029 (1)
    12-o-tetradecanoylphorbol 13-acetate 41.2 3 1672274 (2)

    Search CenterWatch for drugs/clinical trials and news about TRHDE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRHDE gene: 
    NM_013381.2  

    Unigene Cluster for TRHDE:

    Thyrotropin-releasing hormone degrading enzyme
    Hs.199814  [show with all ESTs]
    Unigene Representative Sequence: AF126372
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000548156 ENST00000261180(uc001sxa.3) ENST00000547300 ENST00000552503
    ENST00000549138 ENST00000549401 ENST00000549922
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRHDE
    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate TRHDE (see all 62):
    hsa-miR-302d hsa-miR-520e hsa-miR-4307 hsa-let-7d hsa-miR-200a hsa-let-7a-2* hsa-miR-219-5p hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidTRHDE 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRHDE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRHDE
    Clone
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    OriGene clones in human, mouse for TRHDE (see all 7)
    OriGene ORF clones in mouse, rat for TRHDE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRHDE (NM_013381)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRHDE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRHDE
    Sirion Biotech Customized lentivirus for stable overexpression of TRHDE 
                         Customized lentivirus expression plasmids for stable overexpression of TRHDE 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TRHDE
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRHDE
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRHDE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRHDE

    Additional mRNA sequence: 

    AF126372.1 AK026034.1 AY358765.1 BC023230.1 BC142706.1 BC150181.1 

    3 DOTS entries:

    DT.407501  DT.95365405  DT.91997188 

    24/40 AceView cDNA sequences (see all 40):

    AL700556 AA555212 AK026034 BX283191 BU193089 AI002990 AY358765 T16331 
    BC023230 BI826481 AI631882 CD624938 NM_013381 BP349248 BF790534 CD624923 
    CD624921 AL706544 CD624929 CD624934 AF126372 CD624933 CD624931 CD624937 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRHDE expression in normal human tissues (normalized intensities)      TRHDE embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGATGAATA
    TRHDE Expression
    About this image


    TRHDE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Placenta (Extraembryonic Tissues)
             Decidua-derived mesenchymal cells
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)
     
     Mesenchymal Stem Cells (Muscoskeletal System)
             Decidua-derived mesenchymal cells
     
     Brain (Nervous System)
             prefrontal cortex   

    See TRHDE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRHDE

    SOURCE GeneReport for Unigene cluster: Hs.199814

    UniProtKB/Swiss-Prot: TRHDE_HUMAN, Q9UKU6
    Tissue specificity: Predominantly expressed in brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRHDE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TRHDE gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trhde1 , 5 TRH-degrading enzyme1, 5 90.14(n)1
    95.9(a)1
      10 (61.59 cM)5
    2375531  NM_146241.21  NP_666353.11 
     1143988235 
    chicken
    (Gallus gallus)
    Aves TRHDE1 thyrotropin-releasing hormone degrading enzyme 83.81(n)
    90.21(a)
      427868  XM_425442.2  XP_425442.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    81(a)
    66(a)
    1 ↔ many
    1 ↔ many
    5(38803957-39133264)
    5(38803505-38815575)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5624091 thyrotropin-releasing hormone-degrading ectoenzyme-like 67.44(n)
    67.98(a)
      562409  XM_685797.4  XP_690889.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG119513 membrane alanyl aminopeptidase 34(a)
    (best of 11)
      99A4   --


    ENSEMBL Gene Tree for TRHDE (if available)
    TreeFam Gene Tree for TRHDE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRHDE gene
    LNPEP2  ENPEP2  ANPEP2  ERAP12  AQPEP2  NPEPPS2  ERAP22  
    11 SIMAP similar genes for TRHDE using alignment to 2 protein entries:     TRHDE_HUMAN (see all proteins):
    CD13    TBC1D3    NPEPPSL1    LNPEP    AQPEP    FLJ90650
    ERAP2    NPEPPS    ANPEP    ENPEP    ERAP1

    TRHDE for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6811 SNPs in TRHDE are shown (see all 6811)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs589123451,2
    C--69942873(+) TTTTT-/T/TT  
            
    AAGTT
    1 -- int11NA 2
    rs343638321,2
    C--72587128(+) CCTTT-/TAGTTTG 1 -- int10--------
    rs124246441,2
    C,F,H--72669295(+) ATACGG/AGGGAA 1 -- int1 trp313Minor allele frequency- A:0.05NS EA NA 1678
    rs1503988041,2
    --72669305(+) AAGGCA/CTAGAA 1 -- int10--------
    rs107849601,2
    C,F,A,H--72669426(+) AAAAAC/TCCTGT 1 -- int115Minor allele frequency- T:0.28NS EA NA WA CSA 792
    rs1856690311,2
    --72669478(+) GTTTTG/TGTCAA 1 -- int10--------
    rs79793781,2
    C,F,A,H--72669533(+) CTTGAA/GCCGTA 1 -- int126Minor allele frequency- G:0.18NA NS EA WA CSA 2493
    rs1381668331,2
    C--72669562(+) TAGTGC/TGTATT 1 -- int10--------
    rs731373401,2
    C--72669774(+) TTATTA/GGAGTA 1 -- int10--------
    rs1145484631,2
    F--72670199(+) GTGCAG/ATCCAC 1 -- int11Minor allele frequency- A:0.09WA 118

    HapMap Linkage Disequilibrium report for TRHDE (72481046 - 72731046 bp, first 250kb of TRHDE)

    Structural Variations
         Database of Genomic Variants (DGV) 10/31 variations for TRHDE (see all 31):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1942657CNV Deletion18987734
    esv2746054CNV Deletion23290073
    esv1226093CNV Deletion17803354
    esv3786CNV Deletion18987735
    esv2746055CNV Deletion23290073
    esv2746056CNV Deletion23290073
    esv2746057CNV Deletion23290073
    esv2666571CNV Deletion23128226
    esv987864CNV Deletion20482838
    esv2746052CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606950    OMIM disorders: --

    13 diseases for TRHDE:    About MalaCards
    good syndrome    adenohypophysitis    acromegaly    retinoblastoma
    pituitary adenoma    adenoma    cervical cancer    pneumonia
    cervicitis    rheumatoid arthritis    arthritis    thyroiditis
    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for TRHDE:
    Good syndrome     Cervical cancer

    TRHDE for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TRHDE gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 33.3 3 1672274 (2), 1979029 (1)

    Genetic Association Database (GAD): TRHDE
    Human Genome Epidemiology (HuGE) Navigator: TRHDE (6 documents)

    Export disorders for TRHDE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRHDE gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with TRHDE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human TRH-degrading ectoenzyme cDNA cloning, functional expression, genomic structure and chromosomal assignment. (PubMed id 10491199)1, 2, 3, 9 Schomburg L....Bauer K. (1999)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
    3. Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European suscepti bility loci. (PubMed id 21452313)1, 4 Freudenberg J....Bae S.C. (2011)
    4. Chemerin, a novel adipokine in the regulation of angi ogenesis. (PubMed id 20237162)1, 4 Bozaoglu K....Jowett J.B. (2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Genome-wide association study identifies genetic loci associated with body mass index and high density lipoprotein-cholesterol levels during psychopharmacological treatment - a cross-sectional naturalistic study. (PubMed id 22417934)4 Athanasiu L....Djurovic S. (2012)
    8. Vimentin is a novel AKT1 target mediating motility an d invasion. (PubMed id 20856200)1 Zhu Q.S....Lev D. (2011)
    9. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29953 HGNC: 30748 AceView: TRHDE Ensembl:ENSG00000072657 euGenes: HUgn29953
    ECgene: TRHDE H-InvDB: TRHDE

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRHDE Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRHDE gene:
    Search GeneIP for patents involving TRHDE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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