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Aliases for TRH Gene

Aliases for TRH Gene

  • Thyrotropin-Releasing Hormone 2 3
  • Prothyroliberin 2 3 4
  • Pro-TRH 3 4
  • Pro-Thyrotropin-Releasing Hormone 3
  • Thyrotropin Releasing Hormone 3
  • Thyrotropin-Releasing Factor 3
  • TSH-Releasing Factor 3
  • Protirelin 3
  • TRF 3

External Ids for TRH Gene

Previous GeneCards Identifiers for TRH Gene

  • GC03M126462
  • GC03P130327
  • GC03P130975
  • GC03P131014
  • GC03P131176
  • GC03P129693
  • GC03P127076

Summaries for TRH Gene

Entrez Gene Summary for TRH Gene

  • This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]

GeneCards Summary for TRH Gene

TRH (Thyrotropin-Releasing Hormone) is a Protein Coding gene. Diseases associated with TRH include thyrotropin-releasing hormone deficiency and isolated thyrotropin-releasing hormone deficiency. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include neuropeptide hormone activity and thyrotropin-releasing hormone activity.

UniProtKB/Swiss-Prot for TRH Gene

  • Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRH Gene

Genomics for TRH Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRH Gene

Start:
129,974,305 bp from pter
End:
129,977,938 bp from pter
Size:
3,634 bases
Orientation:
Plus strand

Genomic View for TRH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRH Gene

Proteins for TRH Gene

  • Protein details for TRH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20396-TRH_HUMAN
    Recommended name:
    Pro-thyrotropin-releasing hormone
    Protein Accession:
    P20396
    Secondary Accessions:
    • B2R8R1
    • Q2TB83

    Protein attributes for TRH Gene

    Size:
    242 amino acids
    Molecular mass:
    27404 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRH Gene

Proteomics data for TRH Gene at MOPED

Post-translational modifications for TRH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRH Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TRH Gene

Domains for TRH Gene

Gene Families for TRH Gene

HGNC:

Protein Domains for TRH Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TRH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20396

UniProtKB/Swiss-Prot:

TRH_HUMAN :
  • P20396
Family:
  • Belongs to the TRH family.
genes like me logo Genes that share domains with TRH: view

Function for TRH Gene

Molecular function for TRH Gene

GENATLAS Biochemistry: thyrotropin releasing hormone,precursor with 6 TRH repetitive sequences
UniProtKB/Swiss-Prot Function: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes.

Gene Ontology (GO) - Molecular Function for TRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005184 neuropeptide hormone activity IEA --
GO:0005515 protein binding --
GO:0008437 thyrotropin-releasing hormone activity IEA --
genes like me logo Genes that share ontologies with TRH: view
genes like me logo Genes that share phenotypes with TRH: view

Animal Models for TRH Gene

MGI Knock Outs for TRH:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRH

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TRH Gene

Localization for TRH Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRH Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRH Gene COMPARTMENTS Subcellular localization image for TRH gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2
endoplasmic reticulum 2
golgi apparatus 2
plasma membrane 2
cytoskeleton 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005886 plasma membrane IEA --
GO:0030141 secretory granule IEA --
genes like me logo Genes that share ontologies with TRH: view

Pathways for TRH Gene

genes like me logo Genes that share pathways with TRH: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001692 histamine metabolic process IEA --
GO:0007165 signal transduction TAS 2126343
GO:0007267 cell-cell signaling TAS 2126343
GO:0007628 adult walking behavior IEA --
genes like me logo Genes that share ontologies with TRH: view

Compounds for TRH Gene

(70) Novoseek inferred chemical compound relationships for TRH Gene

Compound -log(P) Hits PubMed IDs
thyroxine 71.9 22
triiodothyronine 71.2 19
ghrp 67.2 14
gnrh 65.8 52
metoclopramide 61 26
genes like me logo Genes that share compounds with TRH: view

Transcripts for TRH Gene

mRNA/cDNA for TRH Gene

Unigene Clusters for TRH Gene

Thyrotropin-releasing hormone:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRH

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRH Gene

No ASD Table

Relevant External Links for TRH Gene

GeneLoc Exon Structure for
TRH
ECgene alternative splicing isoforms for
TRH

Expression for TRH Gene

mRNA expression in normal human tissues for TRH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRH Gene

This gene is overexpressed in Brain - Hypothalamus (29.1) and Cervix - Endocervix (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TRH Gene

SOURCE GeneReport for Unigene cluster for TRH Gene Hs.732877

mRNA Expression by UniProt/SwissProt for TRH Gene

P20396-TRH_HUMAN
Tissue specificity: Hypothalamus. Expressed in the hair follicle epithelium (at protein level).
genes like me logo Genes that share expressions with TRH: view

In Situ Assay Products

Orthologs for TRH Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRH 35
  • 97.64 (n)
  • 97.5 (a)
TRH 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRH 35
  • 79.58 (n)
  • 72.08 (a)
TRH 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRH 35
  • 81.17 (n)
  • 78.66 (a)
TRH 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trh 35
  • 66.81 (n)
  • 57.21 (a)
Trh 16
Trh 36
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRH 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRH 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trh 35
  • 66.96 (n)
  • 57.02 (a)
chicken
(Gallus gallus)
Aves TRH 36
  • 32 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRH 36
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii trh 36
  • 39 (a)
OneToOne
Species with no ortholog for TRH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRH Gene

ENSEMBL:
Gene Tree for TRH (if available)
TreeFam:
Gene Tree for TRH (if available)

Paralogs for TRH Gene

No data available for Paralogs for TRH Gene

Variants for TRH Gene

Sequence variations from dbSNP and Humsavar for TRH Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs5655 -- 129,974,726(+) GGCAG(C/G)CGCCC utr-variant-5-prime
rs5656 -- 129,974,796(+) CCGGA(C/G)CCATC utr-variant-5-prime
rs5657 -- 129,975,816(+) GCCGC(A/G)ATGCC utr-variant-5-prime
rs5658 - 129,975,838(-) AGCGA(C/G)CAGCA reference, missense
rs5659 -- 129,975,876(+) GTCCC(C/G)GGCGG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TRH Gene

Variant ID Type Subtype PubMed ID
dgv1495e1 CNV Complex 17122850
nsv460853 CNV Loss 19166990

Relevant External Links for TRH Gene

HapMap Linkage Disequilibrium report
TRH
Human Gene Mutation Database (HGMD)
TRH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRH Gene

Disorders for TRH Gene

(1) OMIM Diseases for TRH Gene (613879)

(44) Novoseek inferred disease relationships for TRH Gene

Disease -log(P) Hits PubMed IDs
hypothyroidism primary 70 7
acromegaly 65.5 17
hyperprolactinemia 64.4 10
prolactinoma 62.2 3
thyroid hormone resistance 61.6 3

Genatlas disease for TRH Gene

thyrotropin releasing hormone deficiency

Relevant External Links for TRH

Genetic Association Database (GAD)
TRH
Human Genome Epidemiology (HuGE) Navigator
TRH
genes like me logo Genes that share disorders with TRH: view

No data available for UniProtKB/Swiss-Prot for TRH Gene

Publications for TRH Gene

  1. Cloning and structure of human genomic DNA and hypothalamic cDNA encoding human prepro thyrotropin-releasing hormone. (PMID: 2126343) Yamada M. … Wilber J.F. (Mol. Endocrinol. 1990) 2 3 4
  2. Assignment of human preprothyrotropin-releasing hormone (TRH) gene to chromosome 3. (PMID: 1900134) Yamada M. … Wilber J.F. (Somat. Cell Mol. Genet. 1991) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. (PMID: 17137217) Kokubo Y. … Miyata T. (Hypertens. Res. 2006) 3 48
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48

Products for TRH Gene

  • Addgene plasmids for TRH

Sources for TRH Gene

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