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TRH Gene

protein-coding   GIFtS: 56
GCID: GC03P129693

Thyrotropin-Releasing Hormone

  See TRH-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thyrotropin-Releasing Hormone1 2     protirelin2
prothyroliberin1 2     Thyrotropin Releasing Hormone2
Pro-TRH2 3     Thyrotropin-Releasing Factor2
TRF2     TSH-Releasing Factor2
Pro-Thyrotropin-Releasing Hormone2     Prothyroliberin3

External Ids:    HGNC: 122981   Entrez Gene: 72002   Ensembl: ENSG000001708937   OMIM: 6138795   UniProtKB: P203963   

Export aliases for TRH gene to outside databases

Previous GC identifers: GC03M126462 GC03P130327 GC03P130975 GC03P131014 GC03P131176 GC03P127076


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRH Gene:
This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein
releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human
proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in
the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has
been associated with hypothalamic hypothyroidism. (provided by RefSeq, May 2013)

GeneCards Summary for TRH Gene:
TRH (thyrotropin-releasing hormone) is a protein-coding gene. Diseases associated with TRH include thyrotropin-releasing hormone deficiency, and central hypothyroidism and testicular enlargement. GO annotations related to this gene include neuropeptide hormone activity and thyrotropin-releasing hormone activity.

UniProtKB/Swiss-Prot: TRH_HUMAN, P20396
Function: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a
neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft
elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also
increase proliferation and inhibited apoptosis of hair matrix keratinocytes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TRH gene promoter:
         FOXF2   NRSF form 1   Pax-2   Pax-2a   NRSF form 2   GATA-1   FOXJ2 (long isoform)   STAT3   FOXJ2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRH promoter sequence
   Search Chromatin IP Primers for TRH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.3-q21   Ensembl cytogenetic band:  3q22.1   HGNC cytogenetic band: 3q13.3-q21

TRH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRH gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P129693:  view genomic region     (about GC identifiers)

Start:
129,693,114 bp from pter      End:
129,696,781 bp from pter
Size:
3,668 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TRH_HUMAN, P20396 (See protein sequence)
Recommended Name: Pro-thyrotropin-releasing hormone precursor  
Size: 242 amino acids; 27404 Da
Secondary accessions: B2R8R1 Q2TB83

Explore the universe of human proteins at neXtProt for TRH: NX_P20396

Explore proteomics data for TRH at MOPED


See TRH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_009048.1  
ENSEMBL proteins: 
 ENSP00000303452   ENSP00000426522  
Reactome Protein details: P20396

TRH Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for TRH

 
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antibodies-online proteins for TRH (73 products) 

 
antibodies-online peptides for TRH

TRH Antibody Products:

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antibodies-online antibodies for TRH (131 products) 

TRH Assay Products:

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antibodies-online kits for TRH (105 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands

1 InterPro protein domain:
 IPR008857 TRH

Graphical View of Domain Structure for InterPro Entry P20396

ProtoNet protein and cluster: P20396

1 Blocks protein domain: IPB008857 Thyrotropin-releasing hormone

UniProtKB/Swiss-Prot: TRH_HUMAN, P20396
Similarity: Belongs to the TRH family


Find genes that share domains with TRH           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TRH_HUMAN, P20396
Function: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a
neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft
elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also
increase proliferation and inhibited apoptosis of hair matrix keratinocytes

     Genatlas biochemistry entry for TRH:
thyrotropin releasing hormone,precursor with 6 TRH repetitive sequences

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005184neuropeptide hormone activity IEA--
GO:0005515protein binding ----
GO:0008437thyrotropin-releasing hormone activity IEA--
     
Find genes that share ontologies with TRH           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for TRH:
 Cell cycle / mitosis defect  Increased cell number in G1, s 

     4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Trh):
 endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  nervous system 

Find genes that share phenotypes with TRH           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Trhtm1Mmt for TRH

   genOway: Develop your customized and physiologically relevant rodent model for TRH

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat TRH using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate TRH
SwitchGear 3'UTR luciferase reporter plasmidTRH 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for TRH
Predesigned siRNA for gene silencing in human, mouse, rat TRH

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for TRH

Clone
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OriGene clones in human, mouse for TRH (see all 6)
OriGene ORF clones in mouse, rat for TRH
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TRH (NM_007117)
Sino Biological Human cDNA Clone for TRH
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRH
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRH
Addgene plasmids for TRH 

Cell Line
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In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRH


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TRH_HUMAN, P20396: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
nucleus3
cytosol2
endoplasmic reticulum2
golgi apparatus2
plasma membrane2
cytoskeleton1
lysosome1
mitochondrion1

Gene Ontology (GO): 5 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005634nucleus IEA--
GO:0005737cytoplasm ----
GO:0005886plasma membrane IEA--
GO:0030141secretory granule IEA--

Find genes that share ontologies with TRH           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TRH About    
See pathways by source

SuperPathContained pathways About
1Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90
2Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
3Gastrin-CREB signalling pathway via PKC and MAPK
Gastrin-CREB signalling pathway via PKC and MAPK0.90
G alpha (q) signalling events0.90
4Thyroxine (Thyroid Hormone) Production
Thyroxine (Thyroid Hormone) Production
5Development Leptin signaling via JAK STAT and MAPK cascades
Development Leptin signaling via JAK STAT and MAPK cascades


Find genes that share SuperPaths with TRH           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 GeneGo (Thomson Reuters) Pathway for TRH
    Development Leptin signaling via JAK/STAT and MAPK cascades

1 BioSystems Pathway for TRH
    Thyroxine (Thyroid Hormone) Production


2 Reactome Pathways for TRH
    Peptide ligand-binding receptors
G alpha (q) signalling events


    Pathway & Disease-focused RT2 Profiler PCR Array including TRH: 
          Obesity in human mouse rat

Interactions:

    GeneGlobe Interaction Network for TRH

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for TRH (P203963 ENSP000003034524) via UniProtKB, MINT, STRING, and/or I2D (see all 126)
InteractantInteraction Details
GeneCardExternal ID(s)
CPEP168703, ENSP000003861044I2D: score=1 STRING: ENSP00000386104
TRHRP349813, ENSP000003098184I2D: score=1 STRING: ENSP00000309818
ARRB2P321213, ENSP000002692604I2D: score=1 STRING: ENSP00000269260
ADRBK1ENSP000003122624STRING: ENSP00000312262
AGTR1ENSP000002734304STRING: ENSP00000273430
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Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001666response to hypoxia IEA--
GO:0001692histamine metabolic process IEA--
GO:0007165signal transduction TAS2126343
GO:0007267cell-cell signaling TAS2126343
GO:0007628adult walking behavior IEA--

Find genes that share ontologies with TRH           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TRH

Selected Novoseek inferred chemical compound relationships for TRH gene (see all 70)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
thyroxine 71.9 44 8035765 (2), 2119375 (2), 2124532 (2), 9611055 (2) (see all 17)
triiodothyronine 71.2 36 9827656 (3), 2124532 (2), 7816186 (2), 1425022 (1) (see all 15)
ghrp 67.2 27 9768668 (5), 8175966 (5), 7903313 (2), 8370708 (2)
gnrh 65.8 64 7554311 (4), 1333052 (4), 1740485 (3), 8745537 (3) (see all 35)
metoclopramide 61 35 9061507 (4), 7690312 (3), 7889183 (3), 2114023 (3) (see all 12)
pyridostigmine 59.7 17 7581970 (5), 11194708 (2), 1902484 (2), 9440477 (2) (see all 6)
tripeptide 59.6 17 2104988 (1), 1356509 (1), 2109339 (1), 10866938 (1) (see all 11)
acth 58.3 20 8305125 (5), 1333997 (2), 7581945 (2), 1662031 (1) (see all 14)
bromocriptine 56.1 29 11832659 (6), 8127416 (3), 8055814 (3), 1903236 (1) (see all 10)
chlordiazepoxide 40.2 5 8584022 (3), 7816190 (1)



Find genes that share compounds with TRH           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TRH gene: 
NM_007117.4  

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000302649(uc003enc.3) ENST00000507066
miRNA
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SwitchGear 3'UTR luciferase reporter plasmidTRH 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat TRH
Clone
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GenScript: all cDNA clones in your preferred vector: TRH (NM_007117)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRH
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRH
Addgene plasmids for TRH 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for TRH
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRH
  QuantiTect SYBR Green Assays in human, mouse, rat TRH
  QuantiFast Probe-based Assays in human, mouse, rat TRH

Selected AceView cDNA sequences (see all 29):

BM704260 AI703326 BE220630 AW205952 BM715652 T08633 AW339227 BC074889 
NM_007117 BE670731 BC074888 BC069375 AJ714458 BM706926 BE669758 BX106131 
BU728248 T15465 BF058555 AA069640 BM929579 AA205192 BM704171 AI797041 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TRH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGTAAACTTC
TRH Expression
About this image


TRH expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Brain (Nervous System)    fully expand to see all 7 entries
         Thalamus
 
 Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
         Epiblast Stem Cell line 5
 
 Inner Cell Mass (Early Embryonic Tissues)
         Blimp1- mVenus and stella-ECFP genetically modified stem cells
 
 Placenta (Extraembryonic Tissues)
TRH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TRH Protein Expression

UniProtKB/Swiss-Prot: TRH_HUMAN, P20396
Tissue specificity: Hypothalamus. Expressed in the hair follicle epithelium (at protein level)

    Pathway & Disease-focused RT2 Profiler PCR Array including TRH: 
          Obesity in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for TRH
OriGene qSTAR qPCR primer pairs in human, mouse for TRH
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRH
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QuantiFast Probe-based Assays in human, mouse, rat TRH
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRH

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TRH gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Trh1 , 5 thyrotropin releasing hormone1, 5 66.81(n)1
57.21(a)1
  6 (41.03 cM)5
220441  NM_009426.31  NP_033452.21 
 922420615 
chicken
(Gallus gallus)
Aves TRH6
Gallus gallus thyrotropin-releasing hormone (TRH),...
32(a)
1 ↔ 1
12(19683399-19697944)
lizard
(Anolis carolinensis)
Reptilia TRH6
thyrotropin-releasing hormone
37(a)
1 ↔ 1
2(170899393-170906412)
zebrafish
(Danio rerio)
Actinopterygii trh6
thyrotropin-releasing hormone
39(a)
1 ↔ 1
8(56091251-56094016) ENSDARG00000006868


ENSEMBL Gene Tree for TRH (if available)
TreeFam Gene Tree for TRH (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TRH (see all 155)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs716200721,2
C--127076412(+) CTCTC-/CT/CT 
 CT
/TCTT
TCTCT
1 -- us2k11NA 2
rs1891627721,2
--129674932(+) AACAAA/GAACAA 1 -- us2k10--------
rs1418618911,2
C--129674946(+) TCTAGA/CCTGGT 1 -- us2k10--------
rs1929955371,2
--129675053(+) TTGTGC/TTGCTG 1 -- us2k10--------
rs1460595871,2
--129675067(+) TCCAAC/GCTGGG 1 -- us2k10--------
rs1839358001,2
--129675225(+) GAGTGC/GATATG 1 -- us2k10--------
rs752539861,2
F--129675238(+) ACTGCC/TTTATT 1 -- us2k11Minor allele frequency- T:0.07NA 120
rs1173225741,2
C,F--129675324(+) GACATC/GCAGGC 1 -- us2k11Minor allele frequency- G:0.06EA 120
rs1401841551,2
--129675372(+) GAATAA/CCCTGA 1 -- us2k10--------
rs1890542801,2
--129675425(+) GAATTC/GTGAAA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for TRH (129693114 - 129696781 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for TRH:    About this table    
Variant IDTypeSubtypePubMed ID
nsv460853CNV Loss19166990
dgv1495e1CNV Complex17122850

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TRH
DNA2.0 Custom Variant and Variant Library Synthesis for TRH

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 613879   
OMIM disorders: 275120  
15 diseases for TRH:    
About MalaCards
thyrotropin-releasing hormone deficiency    central hypothyroidism and testicular enlargement    generalized resistance to thyroid hormone    adenohypophysitis
isolated acth deficiency    empty sella syndrome    melancholia    pituitary apoplexy
exophthalmos    nodular goiter    euthyroid sick syndrome    hyperthyroxinemia
endogenous depression    myelomeningocele    acth deficiency

Selected diseases from the University of Copenhagen DISEASES database for TRH (see all 29):
Hypothyroidism     Hyperthyroidism     Hyperprolactinemia     Acromegaly
Goiter     Pituitary adenoma     Thyrotoxicosis     Adenoma
Hypopituitarism     Endogenous depression     Amenorrhea     Thyroiditis
Hypoglycemia     Neuroendocrine tumor     Hypersensitivity reaction type II disease     Cushing's syndrome
Hypogonadism     Diabetes insipidus     Hyperthyroxinemia     Pituitary apoplexy

Find genes that share disorders with TRH           About GenesLikeMe

Selected Novoseek inferred disease relationships for TRH gene (see all 44)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
hypothyroidism primary 70 9 2114023 (2), 8035765 (1), 2110573 (1), 7524634 (1) (see all 6)
acromegaly 65.5 25 1957553 (3), 8127416 (2), 8055814 (2), 8370708 (2) (see all 12)
hyperprolactinemia 64.4 10 12735420 (4), 2114023 (3), 1740485 (1), 7971809 (1) (see all 5)
prolactinoma 62.2 3 15251697 (1), 12735420 (1), 1974264 (1)
thyroid hormone resistance 61.6 4 9827656 (2), 9430820 (1)
hypothyroidism 61.2 18 10999119 (3), 1906072 (2), 11508826 (1), 1425022 (1) (see all 14)
pituitary adenoma 58 10 15251697 (3), 1699960 (1), 2291627 (1), 1974264 (1) (see all 7)
pituitary adenoma nonfunctioning 52.7 2 15251697 (1), 7690365 (1)
adenoma 47.2 37 8175966 (4), 15251697 (3), 1974264 (3), 9109848 (2) (see all 14)
hyperthyroidism 46.3 9 2108823 (2), 9405894 (1), 16876577 (1), 7682562 (1) (see all 7)

Genatlas disease: TRH
thyrotropin releasing hormone deficiency

Genetic Association Database (GAD): TRH
Human Genome Epidemiology (HuGE) Navigator: TRH (13 documents)

Export disorders for TRH gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TRH gene, integrated from 10 sources (see all 410):
(articles sorted by number of sources associating them with TRH)
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  1. Cloning and structure of human genomic DNA and hypothalamic cDNA encoding human prepro thyrotropin-releasing hormone. (PubMed id 2126343)1, 2, 3 Yamada M....Wilber J.F. (Mol. Endocrinol. 1990)
  2. Thyrotropin releasing hormone (TRH): a new player in human hair- growth control. (PubMed id 19825978)1, 2 Gaspar E.... Paus R. (FASEB J. 2010)
  3. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
  4. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
  7. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
  8. Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. (PubMed id 17137217)1, 4 Kokubo Y....Miyata T. (Hypertens. Res. 2006)
  9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  10. Assignment of human preprothyrotropin-releasing hormone (TRH) gene to chromosome 3. (PubMed id 1900134)1, 3 Yamada M....Wilber J.F. (Somat. Cell Mol. Genet. 1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7200 HGNC: 12298 AceView: TRH Ensembl:ENSG00000170893 euGenes: HUgn7200
ECgene: TRH H-InvDB: TRH

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TRH Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/Thyrotropin-releasing_hormone

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TRH gene:
Search GeneIP for patents involving TRH

GeneCards and IP:
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