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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRH Gene

protein-coding GIFtS: 56
GCID: GC03P129693

thyrotropin-releasing hormone

Explore 96 diseases affiliated with
TRH via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Thyrotropin-Releasing Hormone¹ ²
Prothyroliberin¹

External Ids:	HGNC: 12298¹	Entrez Gene: 7200²	Ensembl: ENSG00000170893⁷	OMIM: 613879⁵	UniProtKB: P20396³

Export aliases for TRH gene to outside databases

Previous GC identifers: GC03M126462 GC03P130327 GC03P130975 GC03P131014 GC03P131176 GC03P127076

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRH:

This hormone is responsible for the regulation and release of thyroid-stimulating hormone, as well as prolactin.

Deficiency of this hormone has been associated with hypothalamic hypothyroidism. (provided by RefSeq, Sep 2010)

UniProtKB/Swiss-Prot: TRH_HUMAN, P20396

Function: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a

neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation,

prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase

proliferation and inhibited apoptosis of hair matrix keratinocytes

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRH gene promoter:
FOXF2 NRSF form 1 Pax-2 Pax-2a NRSF form 2 GATA-1 FOXJ2 (long isoform) STAT3 FOXJ2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRH promoter sequence

Search SABiosciences Chromatin IP Primers for TRH

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRH

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.3-q21 Ensembl cytogenetic band: 3q22.1 HGNC cytogenetic band: 3q13.3-q21

TRH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRH gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P129693: view genomic region (about GC identifiers)

Start:	129,693,114 bp from pter	End:	129,696,781 bp from pter
Size:	3,668 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRH_HUMAN, P20396 (See protein sequence)

Recommended Name: Prothyroliberin precursor

Size: 242 amino acids; 27404 Da

Subcellular location: Secreted

Secondary accessions: B2R8R1 Q2TB83

Explore the universe of human proteins at neXtProt for TRH: NX_P20396

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P20396

TRH Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_009048.1

ENSEMBL proteins:

ENSP00000303452 ENSP00000426522

Reactome Protein details: P20396
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals TRH Protein Novus Biologicals TRH Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for TRH
	Uscn Proteins for TRH

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005625	soluble fraction	--	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	--	--
GO:0005886	plasma membrane	IEA	--

TRH for ontologies About GeneDecksing

TRH Antibody Products:

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	Uscn Antibodies for TRH
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Assay Products for TRH:

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	Uscn ELISAs and CLIAs for TRH

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TRH for domains About GeneDecksing

1 InterPro domain/family:

IPR008857 TRH

Graphical View of Domain Structure for InterPro Entry P20396

ProtoNet protein and cluster: P20396

1 Blocks protein family: IPB008857 Thyrotropin-releasing hormone

UniProtKB/Swiss-Prot: TRH_HUMAN, P20396

Similarity: Belongs to the TRH family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TRH_HUMAN, P20396

Function: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a

neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation,

prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase

proliferation and inhibited apoptosis of hair matrix keratinocytes

Genatlas biochemistry entry for TRH:

thyrotropin releasing hormone,precursor with 6 TRH repetitive sequences

miRNA Products:		OriGene 3'-UTR Clone: TRH Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRH
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TRH
		SwitchGear 3'UTR luciferase reporter plasmid: TRH 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRH (see all 7) OriGene shRNA RFP: TRH OriGene siRNA: TRH
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRH

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TRH

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRH (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRH OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TRH (NM_007117)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRH
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRH

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TRH
		Search LifeMap BioReagents cell lines for TRH

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRH

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005184	neuropeptide hormone activity	IEA	--
GO:0005515	protein binding	--	--
GO:0008437	thyrotropin-releasing hormone activity	IEA	--

TRH for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for TRH:

Cell cycle / mitosis defect

Increased cell number in G1, s

Animal Models:
Mouse knock-out Trh^tm1Mmt for TRH
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Trh):

endocrine/exocrine gland

growth/size

homeostasis/metabolism

nervous system

TRH for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Development_CNTF receptor signaling

Development_Leptin signaling via JAK/STAT and MAPK cascades

0.25

Development Leptin signaling via JAK/STAT and MAPK cascades

0.25

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TRH

Development Leptin signaling via JAK/STAT and MAPK cascades

1 GeneGo (Thomson Reuters) Pathway for TRH

Development Leptin signaling via JAK/STAT and MAPK cascades

5/8 Reactome Pathways for TRH (see all 8)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

TRH for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TRH

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/125 Interacting proteins for TRH (P20396³ ENSP00000303452⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 125)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CPE	P16870³, ENSP00000386104⁴	I2D: score=1 STRING: ENSP00000386104
TRHR	P34981³, ENSP00000309818⁴	I2D: score=1 STRING: ENSP00000309818
ARRB2	P32121³, ENSP00000269260⁴	I2D: score=1 STRING: ENSP00000269260
ADRA1B	ENSP00000306662⁴	STRING: ENSP00000306662
ADRBK1	ENSP00000312262⁴	STRING: ENSP00000312262

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IEA	--
GO:0007165	signal transduction	TAS	2126343
GO:0007267	cell-cell signaling	TAS	2126343
GO:0007628	adult walking behavior	IEA	--
GO:0009409	response to cold	IEA	--

TRH for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TRH for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRH
10/70 Novoseek chemical compound relationships for TRH gene (see all 70) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
thyroxine	71.9	44	8035765 (2), 2119375 (2), 2124532 (2), 9611055 (2) (see all 17)
triiodothyronine	71.2	36	9827656 (3), 2124532 (2), 7816186 (2), 1425022 (1) (see all 15)
ghrp	67.2	27	9768668 (5), 8175966 (5), 7903313 (2), 8370708 (2)
gnrh	65.8	64	7554311 (4), 1333052 (4), 1740485 (3), 8745537 (3) (see all 35)
metoclopramide	61	35	9061507 (4), 7690312 (3), 7889183 (3), 2114023 (3) (see all 12)
pyridostigmine	59.7	17	7581970 (5), 11194708 (2), 1902484 (2), 9440477 (2) (see all 6)
tripeptide	59.6	17	2104988 (1), 1356509 (1), 2109339 (1), 10866938 (1) (see all 11)
acth	58.3	20	8305125 (5), 1333997 (2), 7581945 (2), 1662031 (1) (see all 14)
bromocriptine	56.1	29	11832659 (6), 8127416 (3), 8055814 (3), 1903236 (1) (see all 10)
chlordiazepoxide	40.2	5	8584022 (3), 7816190 (1)

Search CenterWatch for drugs/clinical trials and news about TRH

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRH gene:

NM_007117.3

Unigene Cluster for TRH:

Thyrotropin-releasing hormone

Hs.732877 [show with all ESTs]

Unigene Representative Sequence: NM_007117

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000302649(uc003enc.3) ENST00000507066

miRNA Products:		OriGene 3'-UTR Clone: TRH Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRH
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TRH
		SwitchGear 3'UTR luciferase reporter plasmid: TRH 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRH (see all 7) OriGene shRNA RFP: TRH OriGene siRNA: TRH
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRH

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRH (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRH OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TRH (NM_007117)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRH
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRH

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRH Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TRH
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRH
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRH

Additional cDNA sequence:

AK313473.1 BC069375.1 BC074888.2 BC074889.2 BC110515.2 BC110516.2

1 DOTS entry:

DT.106377

24/29 AceView cDNA sequences (see all 29):

BM704260 AW205952 T08633 BE220630 AI703326 BM715652 AW339227 BC069375

AJ714458 BM706926 BE669758 BE670731 NM_007117 BU728248 BC074889 BC074888

BX106131 AA069640 T15465 BF058555 AA205192 AI797041 BF058557 BM929579

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTAAACTTC

About this image

TRH expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Hypothalamus

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See TRH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRH

SOURCE GeneReport for Unigene cluster: Hs.732877

UniProtKB/Swiss-Prot: TRH_HUMAN, P20396

Tissue specificity: Hypothalamus. Expressed in the hair follicle epithelium (at protein level)

SABiosciences Expression via Pathway-Focused PCR Array including TRH:

Obesity in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRH

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRH

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TRH gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Trh^{1 , 5}	thyrotropin releasing hormone^{1, 5}	70.61(n)¹ 62.28(a)¹	6 (41.03 cM)⁵ 22044¹ NM_009426.2¹ NP_033452.2¹ 92242061⁵
chicken (Gallus gallus)	Aves	TRH¹	thyrotropin-releasing hormone	49.42(n) 38.16(a)	414344 NM_001030383.1 NP_001025554.1
zebrafish (Danio rerio)	Actinopterygii	trh¹	thyrotropin-releasing hormone	53.94(n) 48.48(a)	266721 NM_001012365.2 NP_001012365.2

ENSEMBL Gene Tree for TRH (if available)
TreeFam Gene Tree for TRH (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75253986^1,2	F,	--	127074843(+)	`ACTGCC/TTTATT`	1	--	us2k¹		1		NA	120
rs72982544^1,2	C,	--	127075783(+)	`TAGAGT/CTGGGT`	1	--	us2k¹		2		WA	120
rs1708214^1,2	C,	--	127076435(-)	`AGAGCA/GAGAGA`	1	--	us2k¹ trp³		0	--	--	--	--
rs7627653^1,2	C,A	--	127076442(+)	`ctcttG/Tctcta`	1	--	ut5¹		0	--	--	--	--
rs76082690^1,2		--	127076678(+)	`GACCCC/TGCGCC`	1	--	ut5¹		0	--	--	--	--
rs9860093^1,2	C,	--	127076724(+)	`GGCTCC/TGGTCC`	1	--	ut5¹		3		NA WA	122
rs5655^1,2	F	--	127076897(+)	`GGCAGG/CCGCCC`	1	--	ut5¹ ese³		2		MN	264
rs5656^1,2	C,F,	--	127076967(+)	`CCGGAC/GCCATC`	1	--	ut5¹ ese³		6		MN NA	514
rs13306056^1,2	C,	--	127077862(+)	`GTGGTC/TCTGCT`	1	--	int¹		0	--	--	--	--
rs13076557^1,2	H	--	127078581(+)	`tactgT/Gtatta`	1	--	int¹		2		NS	214

HapMap Linkage Disequilibrium report for TRH (129693114 - 129696781 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TRH
1 CNV: 3448

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRH

DNA2.0 Custom Variant and Variant Library Synthesis for TRH

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRH for disorders           About GeneDecksing

OMIM gene information: 613879    OMIM disorders: --

20/96 diseases for TRH (see all 96):    About MalaCards

thyrotropin-releasing hormone deficiency hypothyroidism prolactin producing pituitary tumor thyroiditis

newborn respiratory distress syndrome obsessive-compulsive disorder empty sella syndrome langerhans-cell histiocytosis

hypersensitivity reaction type ii disease pseudohypoparathyroidism type ia isolated acth deficiency nontoxic goiter

mccune albright syndrome prader-willi syndrome euthyroid sick syndrome endemic goiter

acth deficiency generalized resistance to thyroid hormone goiter pituitary apoplexy

10/44 Novoseek disease relationships for TRH gene (see all 44) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hypothyroidism primary	70	9	2114023 (2), 8035765 (1), 2110573 (1), 7524634 (1) (see all 6)
acromegaly	65.5	25	1957553 (3), 8127416 (2), 8055814 (2), 8370708 (2) (see all 12)
hyperprolactinemia	64.4	10	12735420 (4), 2114023 (3), 1740485 (1), 7971809 (1) (see all 5)
prolactinoma	62.2	3	15251697 (1), 12735420 (1), 1974264 (1)
thyroid hormone resistance	61.6	4	9827656 (2), 9430820 (1)
hypothyroidism	61.2	18	10999119 (3), 1906072 (2), 11508826 (1), 1425022 (1) (see all 14)
pituitary adenoma	58	10	15251697 (3), 1699960 (1), 2291627 (1), 1974264 (1) (see all 7)
pituitary adenoma nonfunctioning	52.7	2	15251697 (1), 7690365 (1)
adenoma	47.2	37	8175966 (4), 15251697 (3), 1974264 (3), 9109848 (2) (see all 14)
hyperthyroidism	46.3	9	2108823 (2), 9405894 (1), 16876577 (1), 7682562 (1) (see all 7)

Genatlas disease: TRH

thyrotropin releasing hormone deficiency

Human Genome Epidemiology (HuGE) Navigator: TRH (13 documents)

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TRH gene, integrated from 9 sources (see all 396):
(articles sorted by number of sources associating them with TRH)

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Cloning and structure of human genomic DNA and hypothalamic cDNA encoding human prepro thyrotropin-releasing hormone. (PubMed id 2126343)^{1, 2, 3} Yamada M....Wilber J.F. (1990)
Thyrotropin releasing hormone (TRH): a new player in human hair-growth control. (PubMed id 19825978)^{1, 2} GA!spA!r E....Paus R. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Assignment of human preprothyrotropin-releasing hormone (TRH) gene to chromosome 3. (PubMed id 1900134)^{1, 3} Yamada M....Wilber J.F. (1991)
Expression of thyrotropin-releasing hormone by human melanoma and nevi. (PubMed id 15328193)^{1, 9} Ellerhorst J.A....Grimm E.A. (2004)
TRH synthesis in 'mute' thyrotropinomas: cause-effect or coincidence? (PubMed id 12067454)^{1, 9} Badiu C....Coculescu M. (2001)
Identification of thyrotropin-releasing hormone receptor in the rat testis. (PubMed id 7816190)^{1, 9} Satoh T....Wilber J.F. (1994)
Thyrotropin-releasing hormone (TRH) inhibits melanin-c oncentrating hormone neurons: implications for TRH-mediated anorexic and arousal actions. (PubMed id 22378876)¹ Zhang X. and van den Pol A.N. (2012)
Thyrotropin-releasing hormone selectively stimulates human hair follicle pigmentation. (PubMed id 21956127)¹ GA!spA!r E....Paus R. (2011)
Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)¹ Pinheiro A.P....Woodside D.B. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7200	HGNC: 12298	AceView: TRH	Ensembl:ENSG00000170893	euGenes: HUgn7200
ECgene: TRH	H-InvDB: TRH

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TRH	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Thyrotropin-releasing_hormone

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TRH Gene

thyrotropin-releasing hormone

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