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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRH Gene

protein-coding   GIFtS: 61
GCID: GC03P129693

Thyrotropin-Releasing Hormone

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Thyrotropin-Releasing Hormone1 2     protirelin2
prothyroliberin1 2     Thyrotropin Releasing Hormone2
Pro-TRH2 3     Thyrotropin-Releasing Factor2
TRF2     TSH-Releasing Factor2
Pro-Thyrotropin-Releasing Hormone2     Prothyroliberin3

External Ids:    HGNC: 122981   Entrez Gene: 72002   Ensembl: ENSG000001708937   OMIM: 6138795   UniProtKB: P203963   

Export aliases for TRH gene to outside databases

Previous GC identifers: GC03M126462 GC03P130327 GC03P130975 GC03P131014 GC03P131176 GC03P127076


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRH Gene:
This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein
releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human
proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in
the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has
been associated with hypothalamic hypothyroidism. (provided by RefSeq, May 2013)

GeneCards Summary for TRH Gene: 
TRH (thyrotropin-releasing hormone) is a protein-coding gene. Diseases associated with TRH include isolated thyrotropin-releasing hormone deficiency, and generalized resistance to thyroid hormone, and among its related super-pathways are Signaling by GPCR and GPCR ligand binding. GO annotations related to this gene include neuropeptide hormone activity and thyrotropin-releasing hormone activity.

UniProtKB/Swiss-Prot: TRH_HUMAN, P20396
Function: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a
neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft
elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also
increase proliferation and inhibited apoptosis of hair matrix keratinocytes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRH gene promoter:
         FOXF2   NRSF form 1   Pax-2   Pax-2a   NRSF form 2   GATA-1   FOXJ2 (long isoform)   STAT3   FOXJ2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRH promoter sequence
   Search SABiosciences Chromatin IP Primers for TRH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.3-q21   Ensembl cytogenetic band:  3q22.1   HGNC cytogenetic band: 3q13.3-q21

TRH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRH gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P129693:  view genomic region     (about GC identifiers)

Start:
129,693,114 bp from pter      End:
129,696,781 bp from pter
Size:
3,668 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRH_HUMAN, P20396 (See protein sequence)
Recommended Name: Pro-thyrotropin-releasing hormone precursor  
Size: 242 amino acids; 27404 Da
Subcellular location: Secreted
Secondary accessions: B2R8R1 Q2TB83

Explore the universe of human proteins at neXtProt for TRH: NX_P20396

Explore proteomics data for TRH at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20396

  • TRH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRH Protein Expression
    REFSEQ proteins: NP_009048.1  
    ENSEMBL proteins: 
     ENSP00000303452   ENSP00000426522  
    Reactome Protein details: P20396
    Human Recombinant Protein Products for TRH: 
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    OriGene Protein Over-expression Lysate for TRH
    OriGene MassSpec for TRH 
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    GenScript Custom Purified and Recombinant Proteins Services for TRH
    Novus Biologicals TRH Protein
    Novus Biologicals TRH Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TRH
    Cloud-Clone Corp. Proteins for TRH 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IEA--
    GO:0030141secretory granule IEA--

    TRH for ontologies           About GeneDecksing



    TRH Antibody Products: 
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    Novus Biologicals TRH Antibodies
    Abcam antibodies for TRH
    Cloud-Clone Corp. Antibodies for TRH 
    ThermoFisher Antibodies for TRH
    LSBio Antibodies in human, mouse, rat for TRH 

    Assay Products for TRH: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for TRH


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    1 InterPro protein domain:
     IPR008857 TRH

    Graphical View of Domain Structure for InterPro Entry P20396

    ProtoNet protein and cluster: P20396

    1 Blocks protein domain: IPB008857 Thyrotropin-releasing hormone

    UniProtKB/Swiss-Prot: TRH_HUMAN, P20396
    Similarity: Belongs to the TRH family


    TRH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRH_HUMAN, P20396
    Function: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a
    neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft
    elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also
    increase proliferation and inhibited apoptosis of hair matrix keratinocytes

         Genatlas biochemistry entry for TRH:
    thyrotropin releasing hormone,precursor with 6 TRH repetitive sequences

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005184neuropeptide hormone activity IEA--
    GO:0005515protein binding ----
    GO:0008437thyrotropin-releasing hormone activity IEA--
         
    TRH for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRH:
     Cell cycle / mitosis defect  Increased cell number in G1, s 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Trh):
     endocrine/exocrine gland  growth/size  homeostasis/metabolism  nervous system 

    TRH for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Trhtm1Mmt for TRH

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRH 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRH 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRH 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRH
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TRH
    SwitchGear 3'UTR luciferase reporter plasmidTRH 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: TRH (NM_007117)
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                         Customized lentivirus expression plasmids for stable overexpression of TRH 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRH


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRH About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    3G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Development Leptin signaling via JAK/STAT and MAPK cascades
    Development Leptin signaling via JAK/STAT and MAPK cascades1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TRH
        Development Leptin signaling via JAK/STAT and MAPK cascades


    1 GeneGo (Thomson Reuters) Pathway for TRH
        Development Leptin signaling via JAK/STAT and MAPK cascades


    5/8        Reactome Pathways for TRH (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding



    TRH for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/125 Interacting proteins for TRH (P203963 ENSP000003034524) via UniProtKB, MINT, STRING, and/or I2D (see all 125)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPEP168703, ENSP000003861044I2D: score=1 STRING: ENSP00000386104
    TRHRP349813, ENSP000003098184I2D: score=1 STRING: ENSP00000309818
    ARRB2P321213, ENSP000002692604I2D: score=1 STRING: ENSP00000269260
    ADRA1BENSP000003066624STRING: ENSP00000306662
    ADRBK1ENSP000003122624STRING: ENSP00000312262
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0007165signal transduction TAS2126343
    GO:0007267cell-cell signaling TAS2126343
    GO:0007628adult walking behavior IEA--
    GO:0009409response to cold IEA--

    TRH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRH

    10/70 Novoseek inferred chemical compound relationships for TRH gene (see all 70)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroxine 71.9 44 8035765 (2), 2119375 (2), 2124532 (2), 9611055 (2) (see all 17)
    triiodothyronine 71.2 36 9827656 (3), 2124532 (2), 7816186 (2), 1425022 (1) (see all 15)
    ghrp 67.2 27 9768668 (5), 8175966 (5), 7903313 (2), 8370708 (2)
    gnrh 65.8 64 7554311 (4), 1333052 (4), 1740485 (3), 8745537 (3) (see all 35)
    metoclopramide 61 35 9061507 (4), 7690312 (3), 7889183 (3), 2114023 (3) (see all 12)
    pyridostigmine 59.7 17 7581970 (5), 11194708 (2), 1902484 (2), 9440477 (2) (see all 6)
    tripeptide 59.6 17 2104988 (1), 1356509 (1), 2109339 (1), 10866938 (1) (see all 11)
    acth 58.3 20 8305125 (5), 1333997 (2), 7581945 (2), 1662031 (1) (see all 14)
    bromocriptine 56.1 29 11832659 (6), 8127416 (3), 8055814 (3), 1903236 (1) (see all 10)
    chlordiazepoxide 40.2 5 8584022 (3), 7816190 (1)

    Search CenterWatch for drugs/clinical trials and news about TRH

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRH gene: 
    NM_007117.4  

    Unigene Cluster for TRH:

    Thyrotropin-releasing hormone
    Hs.732877  [show with all ESTs]
    Unigene Representative Sequence: NM_007117
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302649(uc003enc.3) ENST00000507066

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TRH
    SwitchGear 3'UTR luciferase reporter plasmidTRH 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRH
    Clone
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    GenScript: all cDNA clones in your preferred vector: TRH (NM_007117)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRH
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                         Customized lentivirus expression plasmids for stable overexpression of TRH 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRH

    Additional mRNA sequence: 

    AK313473.1 BC069375.1 BC074888.2 BC074889.2 BC110515.2 BC110516.2 

    1 DOTS entry:

    DT.106377 

    24/29 AceView cDNA sequences (see all 29):

    BM715652 T08633 AW205952 BM704260 AI703326 BE220630 BC074889 AJ714458 
    BC074888 BE669758 BU728248 BX106131 NM_007117 BM706926 BE670731 AW339227 
    BC069375 BF058555 AA069640 T15465 AA205192 BM929579 BM704171 BF058557 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRH expression in normal human tissues (normalized intensities)      TRH embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAAACTTC
    TRH Expression
    About this image


    TRH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Thalamus
             Septum   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Sox17-GFP genetically modified stem cells
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Stem Cell line 5
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Ventral Horn   
     
     Bone (Muscoskeletal System)
             Normal Human osteoblasts (NHOST)   

    See TRH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRH

    SOURCE GeneReport for Unigene cluster: Hs.732877

    UniProtKB/Swiss-Prot: TRH_HUMAN, P20396
    Tissue specificity: Hypothalamus. Expressed in the hair follicle epithelium (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Array including TRH: 
              Obesity in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TRH gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trh1 , 5 thyrotropin releasing hormone1, 5 70.61(n)1
    62.28(a)1
      6 (41.03 cM)5
    220441  NM_009426.21  NP_033452.21 
     922420615 
    chicken
    (Gallus gallus)
    Aves TRH1 thyrotropin-releasing hormone 49.42(n)
    38.16(a)
      414344  NM_001030383.1  NP_001025554.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRH6
    thyrotropin-releasing hormone
    36(a)
    1 ↔ 1
    2(170899393-170906412)
    zebrafish
    (Danio rerio)
    Actinopterygii trh1 thyrotropin-releasing hormone 53.94(n)
    48.48(a)
      266721  NM_001012365.2  NP_001012365.2 


    ENSEMBL Gene Tree for TRH (if available)
    TreeFam Gene Tree for TRH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/155 SNPs in TRH are shown (see all 155)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs716200721,2
    C--127076412(+) CTCTC-/CT/CT 
     CT
    /TCTT
    TCTCT
    1 -- us2k11NA 2
    rs1891627721,2
    --129674932(+) AACAAA/GAACAA 1 -- us2k10--------
    rs1418618911,2
    C--129674946(+) TCTAGA/CCTGGT 1 -- us2k10--------
    rs1929955371,2
    --129675053(+) TTGTGC/TTGCTG 1 -- us2k10--------
    rs1460595871,2
    --129675067(+) TCCAAC/GCTGGG 1 -- us2k10--------
    rs1839358001,2
    --129675225(+) GAGTGC/GATATG 1 -- us2k10--------
    rs752539861,2
    F--129675238(+) ACTGCC/TTTATT 1 -- us2k11Minor allele frequency- T:0.07NA 120
    rs1173225741,2
    C,F--129675324(+) GACATC/GCAGGC 1 -- us2k11Minor allele frequency- G:0.06EA 120
    rs1401841551,2
    --129675372(+) GAATAA/CCCTGA 1 -- us2k10--------
    rs1890542801,2
    --129675425(+) GAATTC/GTGAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRH (129693114 - 129696781 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TRH:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv460853CNV Loss19166990
    dgv1495e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613879    OMIM disorders: --

    20/90 diseases for TRH (see all 90):    About MalaCards
    isolated thyrotropin-releasing hormone deficiency    generalized resistance to thyroid hormone    prolactin producing pituitary tumor    empty sella syndrome
    isolated acth deficiency    endemic goiter    neonatal thyrotoxicosis    nontoxic goiter
    newborn respiratory distress syndrome    pituitary apoplexy    melancholia    nodular goiter
    reactive arthritis    endogenous depression    hyperthyroxinemia    euthyroid sick syndrome
    myelomeningocele    thyrotoxicosis    pseudohypoparathyroidism    acth deficiency

    20/29 diseases from the University of Copenhagen DISEASES database for TRH (see all 29):
    Hypothyroidism     Hyperthyroidism     Hyperprolactinemia     Acromegaly
    Goiter     Pituitary adenoma     Thyrotoxicosis     Adenoma
    Hypopituitarism     Endogenous depression     Amenorrhea     Thyroiditis
    Hypoglycemia     Neuroendocrine tumor     Hypersensitivity reaction type II disease     Cushing's syndrome
    Hypogonadism     Diabetes insipidus     Hyperthyroxinemia     Pituitary apoplexy

    TRH for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/44 Novoseek inferred disease relationships for TRH gene (see all 44)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypothyroidism primary 70 9 2114023 (2), 8035765 (1), 2110573 (1), 7524634 (1) (see all 6)
    acromegaly 65.5 25 1957553 (3), 8127416 (2), 8055814 (2), 8370708 (2) (see all 12)
    hyperprolactinemia 64.4 10 12735420 (4), 2114023 (3), 1740485 (1), 7971809 (1) (see all 5)
    prolactinoma 62.2 3 15251697 (1), 12735420 (1), 1974264 (1)
    thyroid hormone resistance 61.6 4 9827656 (2), 9430820 (1)
    hypothyroidism 61.2 18 10999119 (3), 1906072 (2), 11508826 (1), 1425022 (1) (see all 14)
    pituitary adenoma 58 10 15251697 (3), 1699960 (1), 2291627 (1), 1974264 (1) (see all 7)
    pituitary adenoma nonfunctioning 52.7 2 15251697 (1), 7690365 (1)
    adenoma 47.2 37 8175966 (4), 15251697 (3), 1974264 (3), 9109848 (2) (see all 14)
    hyperthyroidism 46.3 9 2108823 (2), 9405894 (1), 16876577 (1), 7682562 (1) (see all 7)

    Genatlas disease: TRH
    thyrotropin releasing hormone deficiency

    Genetic Association Database (GAD): TRH
    Human Genome Epidemiology (HuGE) Navigator: TRH (13 documents)

    Export disorders for TRH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRH gene, integrated from 9 sources (see all 409):
    (articles sorted by number of sources associating them with TRH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and structure of human genomic DNA and hypothalamic cDNA encoding human prepro thyrotropin-releasing hormone. (PubMed id 2126343)1, 2, 3 Yamada M....Wilber J.F. (1990)
    2. Thyrotropin releasing hormone (TRH): a new player in human hair-growth control. (PubMed id 19825978)1, 2 GA!spA!r E....Paus R. (2010)
    3. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    4. Comprehensive copy number variant (CNV) analysis of n euronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    7. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    8. Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. (PubMed id 17137217)1, 4 Kokubo Y....Miyata T. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Assignment of human preprothyrotropin-releasing hormone (TRH) gene to chromosome 3. (PubMed id 1900134)1, 3 Yamada M....Wilber J.F. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7200 HGNC: 12298 AceView: TRH Ensembl:ENSG00000170893 euGenes: HUgn7200
    ECgene: TRH H-InvDB: TRH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRH Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Thyrotropin-releasing_hormone

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRH gene:
    Search GeneIP for patents involving TRH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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