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Aliases for TRGV9 Gene

Aliases for TRGV9 Gene

  • T-Cell Receptor Gamma Variable 9 2 5
  • T-Cell Receptor, Gamma, Variable Region V9 2 3
  • T Cell Receptor Gamma Variable 9 2 3
  • TCRGV9 3
  • TRGC1 3
  • V2 3

External Ids for TRGV9 Gene

Previous HGNC Symbols for TRGV9 Gene

  • TCRGV9

Previous GeneCards Identifiers for TRGV9 Gene

  • GC07M038002
  • GC07M038062
  • GC07M038096
  • GC07M038054
  • GC07M038131
  • GC07M038245
  • GC07M038324
  • GC07M038298
  • GC07M038356
  • GC07M038447

Summaries for TRGV9 Gene

GeneCards Summary for TRGV9 Gene

TRGV9 (T-Cell Receptor Gamma Variable 9) is a Protein Coding gene. GO annotations related to this gene include peptide antigen binding and MHC protein binding. An important paralog of this gene is TRGV10.

Gene Wiki entry for TRGV9 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRGV9 Gene

Genomics for TRGV9 Gene

Regulatory Elements for TRGV9 Gene

Enhancers for TRGV9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G038307 1.5 FANTOM5 ENCODE dbSUPER 5.5 +9.0 9044 4.4 HDGF ATF1 CREB3L1 YY1 GLIS2 ZNF143 KDM4B ZNF263 SP3 ZNF592 TRGV9 STARD3NL TRGV5 TARP LOC103689914
GH07G038315 1.3 Ensembl ENCODE dbSUPER 6.1 +0.7 669 5.3 CTCF RB1 TEAD4 MAX NFXL1 EBF1 RAD21 CTBP1 ZBTB48 EGR1 STARD3NL ENSG00000272908 TRGV9 TRGV4 PIR35489
GH07G038301 1 dbSUPER 7 +16.7 16728 1.0 HDGF ATF1 PKNOX1 CREB3L1 ARNT KLF13 ZNF263 JUNB NCOA1 REST STARD3NL TRGV9 TRGV4 TRGV10 TARP
GH07G038303 1 ENCODE dbSUPER 4.8 +13.2 13229 3.4 CTCF NFXL1 ZNF384 ZBTB40 RAD21 TCF12 ZNF366 ZBTB48 EGR1 EED ENSG00000272908 TRGV5P TRGV4 TRGV5 TRGV9 TRGV3 TARP TRGV10
GH07G038312 0.7 ENCODE dbSUPER 5.4 +5.3 5331 2.2 IKZF1 IRF1 TRGC2 TRGV9 GC07P038314 PIR35489
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRGV9 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRGV9 Gene

Chromosome:
7
Start:
38,317,017 bp from pter
End:
38,318,861 bp from pter
Size:
1,845 bases
Orientation:
Minus strand

Genomic View for TRGV9 Gene

Genes around TRGV9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRGV9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRGV9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRGV9 Gene

Proteins for TRGV9 Gene

  • Protein details for TRGV9 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q99603
    Recommended name:
    T-cell receptor gamma variable 9
    Protein Accession:
    Q99603

    Protein attributes for TRGV9 Gene

    Size:
    122 amino acids
    Molecular mass:
    13414 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRGV9 Gene

Post-translational modifications for TRGV9 Gene

No Post-translational modifications

Other Protein References for TRGV9 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRGV9 Gene

Domains & Families for TRGV9 Gene

Gene Families for TRGV9 Gene

Protein Domains for TRGV9 Gene

Suggested Antigen Peptide Sequences for TRGV9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRGV9: view

No data available for UniProtKB/Swiss-Prot for TRGV9 Gene

Function for TRGV9 Gene

Gene Ontology (GO) - Molecular Function for TRGV9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042287 MHC protein binding NAS --
GO:0042605 peptide antigen binding NAS --
genes like me logo Genes that share ontologies with TRGV9: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRGV9 Gene

Localization for TRGV9 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRGV9 Gene

Pathways & Interactions for TRGV9 Gene

SuperPathways for TRGV9 Gene

No Data Available

Interacting Proteins for TRGV9 Gene

Gene Ontology (GO) - Biological Process for TRGV9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRGV9 Gene

Transcripts for TRGV9 Gene

mRNA/cDNA for TRGV9 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRGV9 Gene

No ASD Table

Relevant External Links for TRGV9 Gene

GeneLoc Exon Structure for
TRGV9
ECgene alternative splicing isoforms for
TRGV9

Expression for TRGV9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRGV9 Gene

mRNA differential expression in normal tissues according to GTEx for TRGV9 Gene

This gene is overexpressed in Whole Blood (x20.4), Prostate (x8.5), and Spleen (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of TRGV9 Gene:

TRGV9
genes like me logo Genes that share expression patterns with TRGV9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRGV9 Gene

Orthologs for TRGV9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRGV9 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia TRGV9 35
  • 36 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 28 (a)
ManyToMany
Species where no ortholog for TRGV9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRGV9 Gene

ENSEMBL:
Gene Tree for TRGV9 (if available)
TreeFam:
Gene Tree for TRGV9 (if available)

Paralogs for TRGV9 Gene

Variants for TRGV9 Gene

Relevant External Links for TRGV9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRGV9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRGV9 Gene

Disorders for TRGV9 Gene

Relevant External Links for TRGV9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRGV9

No disorders were found for TRGV9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRGV9 Gene

Publications for TRGV9 Gene

  1. Functional and structural similarity of V gamma 9V delta 2 T cells in humans and Aotus monkeys, a primate infection model for Plasmodium falciparum malaria. (PMID: 11714808) Daubenberger C.A. … Pluschke G. (J. Immunol. 2001) 3 22 64
  2. The promoter regions of the T-cell receptor V9 gamma (TRGV9) and V2 delta (TRDV2) genes display short direct repeats but no TATA box. (PMID: 2806544) Dariavach P. … Lefranc M.P. (FEBS Lett. 1989) 2 3 64
  3. Variable region genes in the human T-cell rearranging gamma (TRG) locus: V-J junction and homology with the mouse genes. (PMID: 2969332) Huck S. … Lefranc M.P. (EMBO J. 1988) 2 3 64
  4. Large scale expansion of Vgamma9Vdelta2 T lymphocytes from human peripheral blood mononuclear cells after a positive selection using MACS "TCR gamma/delta+ T cell isolation kit". (PMID: 19465023) Salot S. … Sicard H. (J. Immunol. Methods 2009) 3 64
  5. Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. (PMID: 19494338) Li J. … Herrmann T. (J. Immunol. 2009) 3 64

Products for TRGV9 Gene

Sources for TRGV9 Gene

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