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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRGV9 Gene

protein-coding   GIFtS: 24
GCID: GC07M038356

T cell receptor gamma variable 9


(Previous symbol: TCRGV9)
 Explore 5 diseases affiliated with
TRGV9 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRGV9    

Aliases
for TRGV9 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
T Cell Receptor Gamma Variable 91 2
TCRGV91 2
V21 2
TRGC12

External Ids:    HGNC: 122951   Entrez Gene: 69832   Ensembl: ENSG000002116957   UniProtKB: Q996034   UniProtKB: Q996044   

Export aliases for TRGV9 gene to outside databases

Previous GC identifers: GC07M038002 GC07M038062 GC07M038096 GC07M038054 GC07M038131 GC07M038245 GC07M038324 GC07M038298 GC07M038396


Summaries
for TRGV9 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Gene Wiki entry for TRGV9


Genomic Views
for TRGV9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TRGV9
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRGV9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p14

TRGV9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRGV9 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M038356:  view genomic region     (about GC identifiers)

Start:
 38,356,618 bp from pter      End:
 38,358,462 bp from pter
Size:
 1,845 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 38,394,300-38,394,775     

Proteins
for TRGV9 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/TrEMBL: Q99603 (See protein sequence)
Recommended Name: TRGV9 protein  
Size: 122 amino acids; 13414 Da

UniProtKB/TrEMBL: Q99604 (See protein sequence)

Recommended Name: TRGV9 protein  
Size: 122 amino acids; 13441 Da

TRGV9 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).


ENSEMBL proteins: 
 ENSP00000391561  

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Protein Domains /
Families
for TRGV9 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
TRGV9 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR007110 Ig-like_dom
 IPR003596 Ig_V-set_subgr
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry Q99603
Graphical View of Domain Structure for InterPro Entry Q99604

ProtoNet protein and cluster: Q99603

2 Blocks protein families:
IPB003596 Immunoglobulin V-type
IPB013106 Immunoglobulin V-set



Function
for TRGV9 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
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Inhib. RNA
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Gene Editing
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In Situ Assay
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Pathways & Interactions
for TRGV9 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRGV9

Drugs & Compounds
for TRGV9 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRGV9
Search CenterWatch for drugs/clinical trials and news about TRGV9 

Transcripts
for TRGV9 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000444775

miRNA
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Inhib. RNA
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Browse OriGene siRNA
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Clone
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Primer
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24/359 AceView cDNA sequences (see all 359):

BX281781 AW575113 R33649 NM_001003806 NM_001003799 CR605178 BQ002856 BM478583 
AV715641 AI823897 BF674593 AI768834 BF109398 AV714756 BV205007 BX504327 
BC030554 AI961098 BC062761 BM544213 BM922364 BQ934484 CA449324 BV205008 

GeneLoc Exon Structure


Expression
for TRGV9 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRGV9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image
See TRGV9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRGV9
    SABiosciences Custom PCR Arrays for TRGV9
Primer
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In Situ
Assay Products: 
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Orthologs
for TRGV9 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
   --

ENSEMBL Gene Tree for TRGV9 (if available)
TreeFam Gene Tree for TRGV9 (if available) 

Paralogs
for TRGV9 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TRGV9 gene
TRGV102  TRGV112  
18/58 SIMAP similar genes for TRGV9 using alignment to 2 protein entries:     Q99603_HUMAN (see all proteins) (see all similar genes):
LOC402482    BV18S1J1.5    DKFZp686E23209    TRGV11    DKFZp686H20196    IgH
TCRBV6S5A2    VHCH1    VH3    HEL180    IGLV    IGLV4-69
V4-3    IGLV4-60    TCRBV18S1    VH    DKFZp686M08189    IGHV

TRGV9 for paralogs           About GeneDecksing



Genomic Variants
for TRGV9 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRGV9
DNA2.0 Custom Variant and Variant Library Synthesis for TRGV9

Disorders / Diseases
for TRGV9 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
TRGV9 for disorders           About GeneDecksing

5 diseases for TRGV9:    About MalaCards
plasmodium falciparum malaria    colon carcinoma    malaria    carcinoma
prostatitis


Export disorders for TRGV9 gene to outside databases

Publications
for TRGV9 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TRGV9 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with TRGV9)		    Utopia: connect your pdf to the dynamic
world of online information

  1. The promoter regions of the T-cell receptor V9 gamma (TRGV9) and V2 delta (TRDV2) genes display short direct repeats but no TATA box. (PubMed id 2806544)1, 3 Dariavach P. and Lefranc M.P. (1989)
  2. Variable region genes in the human T-cell rearranging gamma (TRG) locus: V-J junction and homology with the mouse genes. (PubMed id 2969332)1, 3 Huck S....Lefranc M.P. (1988)
  3. Functional and structural similarity of V gamma 9V delta 2 T cells in humans and Aotus monkeys, a primate infection model for Plasmodium falciparum malaria. (PubMed id 11714808)1, 9 Daubenberger C.A....Pluschke G. (2001)
  4. Large scale expansion of Vgamma9Vdelta2 T lymphocytes from human peripheral blood mononuclear cells after a positive selection using MACS 'TCR gamma/delta+ T cell isolation kit'. (PubMed id 19465023)1 Salot S....Sicard H. (2009)
  5. Reduced expression of the mevalonate pathway enzyme f arnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vde lta2 T cells. (PubMed id 19494338)1 Li J....Herrmann T. (2009)
  6. V gamma 9V delta 2 T cell response to colon carcinoma cells. (PubMed id 16210656)1 Corvaisier M....Jotereau F. (2005)
  7. The T cell receptor gamma chain alternate reading frame protein (TARP), a prostate-specific protein localized in mitochondria. (PubMed id 15150260)1 Maeda H....Pastan I. (2004)
  8. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (2003)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  10. High expression of a specific T-cell receptor gamma transcript in epithelial cells of the prostate. (PubMed id 10430935)1 Essand M....Pastan I. (1999)

External Searches for TRGV9 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing TRGV9 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 6983 HGNC: 12295 AceView: TRG_ Ensembl:ENSG00000211695 euGenes: HUgn6983
ECgene: TRGV9 H-InvDB: TRGV9

Other Databases showing TRGV9 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing TRGV9 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TRGV9 Pharmacogenomics, SNPs, Pathways
IMGT entry for TRGV9 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for TRGV9 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TRGV9 gene:
Search GeneIP for patents involving TRGV9

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for TRGV9 gene

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In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 
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