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Aliases for TRGC2 Gene

Aliases for TRGC2 Gene

  • T Cell Receptor Gamma Constant 2 2 3 5
  • T-Cell Receptor, Gamma, Constant Region C2 2 3
  • TCRGC2 3 4
  • T-Cell Receptor Gamma Chain C Region PT-Gamma-1/2 4
  • TRGC2(2X) 3
  • TRGC2(3X) 3

External Ids for TRGC2 Gene

Previous HGNC Symbols for TRGC2 Gene

  • TCRGC2

Previous GeneCards Identifiers for TRGC2 Gene

  • GC07U990099
  • GC07M037986
  • GC07M038023
  • GC07M038024
  • GC07M038052
  • GC07M038246

Summaries for TRGC2 Gene

GeneCards Summary for TRGC2 Gene

TRGC2 (T Cell Receptor Gamma Constant 2) is a Protein Coding gene. GO annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is TRGC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRGC2 Gene

Genomics for TRGC2 Gene

Regulatory Elements for TRGC2 Gene

Enhancers for TRGC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F038231 1.4 FANTOM5 Ensembl ENCODE 16.9 +15.8 15811 4.8 BCOR CTCF WRNIP1 MAX ZMYM3 GATA3 ADNP CHD2 MTA2 TRIM22 TRGC2 STARD3NL TARP
GH07F038255 1 Ensembl ENCODE 19.6 -7.4 -7384 2.0 MTA2 NR4A1 TRIM22 CEBPB ZBTB40 TBX21 RAD51 IKZF1 TARDBP ZNF207 TRGC2 TRGC1 TRGJP2 GC07P038264
GH07F038215 1.1 Ensembl ENCODE 16.9 +30.3 30256 8.2 ELF3 ATF1 PKNOX1 CBX3 ZBTB40 RAD21 ZNF143 ETV6 ZNF654 CEBPB STARD3NL TRGC2 SFRP4
GH07F038242 1.2 FANTOM5 Ensembl ENCODE 14.6 +6.4 6423 1.7 IRF9 FOSL1 ZNF316 PBX2 MAFG CEBPB EMSY TRGC2 STARD3NL TRGC1
GH07F038195 1 Ensembl ENCODE 16.8 +52.2 52172 3.2 NFIA CHD1 REST ZNF316 SMARCA4 ZBTB48 ZNF366 POLR2A ZNF512 HMBOX1 TRGC2 STARD3NL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRGC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRGC2 Gene

Chromosome:
7
Start:
38,239,580 bp from pter
End:
38,249,572 bp from pter
Size:
9,993 bases
Orientation:
Minus strand

Genomic View for TRGC2 Gene

Genes around TRGC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRGC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRGC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRGC2 Gene

Proteins for TRGC2 Gene

  • Protein details for TRGC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P03986-TRGC2_HUMAN
    Recommended name:
    T-cell receptor gamma-2 chain C region
    Protein Accession:
    P03986

    Protein attributes for TRGC2 Gene

    Size:
    189 amino acids
    Molecular mass:
    21554 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TRGC2 Gene

neXtProt entry for TRGC2 Gene

Post-translational modifications for TRGC2 Gene

  • Glycosylation at Asn 66, Asn 136, Asn 142, and Asn 151

Other Protein References for TRGC2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRGC2 Gene

Domains & Families for TRGC2 Gene

Gene Families for TRGC2 Gene

Protein Domains for TRGC2 Gene

Suggested Antigen Peptide Sequences for TRGC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P03986

UniProtKB/Swiss-Prot:

TRGC2_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with TRGC2: view

Function for TRGC2 Gene

Gene Ontology (GO) - Molecular Function for TRGC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity NAS 3458221
genes like me logo Genes that share ontologies with TRGC2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRGC2 Gene

Localization for TRGC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRGC2 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TRGC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane NAS 3458221
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TRGC2: view

No data available for Subcellular locations from COMPARTMENTS for TRGC2 Gene

Pathways & Interactions for TRGC2 Gene

SuperPathways for TRGC2 Gene

No Data Available

Interacting Proteins for TRGC2 Gene

Selected Interacting proteins: P03986-TRGC2_HUMAN for TRGC2 Gene via IID

Gene Ontology (GO) - Biological Process for TRGC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 3458221
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with TRGC2: view

No data available for Pathways by source and SIGNOR curated interactions for TRGC2 Gene

Transcripts for TRGC2 Gene

mRNA/cDNA for TRGC2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRGC2 Gene

No ASD Table

Relevant External Links for TRGC2 Gene

GeneLoc Exon Structure for
TRGC2
ECgene alternative splicing isoforms for
TRGC2

Expression for TRGC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRGC2 Gene

mRNA differential expression in normal tissues according to GTEx for TRGC2 Gene

This gene is overexpressed in Whole Blood (x17.4), Prostate (x5.2), and Spleen (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of TRGC2 Gene:

TRGC2
genes like me logo Genes that share expression patterns with TRGC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRGC2 Gene

Orthologs for TRGC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRGC2 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Tcrg-C1 35
  • 69 (a)
ManyToMany
Tcrg-C3 35
  • 69 (a)
ManyToMany
Tcrg-C2 35
  • 68 (a)
ManyToMany
Tcrg-C4 35
  • 48 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 55 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 52 (a)
ManyToMany
-- 35
  • 49 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 31 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 30 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 13 (a)
OneToMany
Species where no ortholog for TRGC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRGC2 Gene

ENSEMBL:
Gene Tree for TRGC2 (if available)
TreeFam:
Gene Tree for TRGC2 (if available)

Paralogs for TRGC2 Gene

Paralogs for TRGC2 Gene

(2) SIMAP similar genes for TRGC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRGC2: view

Variants for TRGC2 Gene

Relevant External Links for TRGC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRGC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRGC2 Gene

Disorders for TRGC2 Gene

Relevant External Links for TRGC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRGC2

No disorders were found for TRGC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRGC2 Gene

Publications for TRGC2 Gene

  1. Cloning and sequence analysis of complementary DNA encoding an aberrantly rearranged human T-cell gamma chain. (PMID: 3458221) Dialynas D.P. … Strominger J.L. (Proc. Natl. Acad. Sci. U.S.A. 1986) 2 3 4 64
  2. Structure of a human gammadelta T-cell antigen receptor. (PMID: 11459064) Allison T.J. … Garboczi D.N. (Nature 2001) 3 4 64
  3. Genetic polymorphism and exon changes of the constant regions of the human T-cell rearranging gene gamma. (PMID: 2879283) Lefranc M.P. … Rabbitts T.H. (Proc. Natl. Acad. Sci. U.S.A. 1986) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  5. The human T-cell receptor gamma (TRG) genes. (PMID: 2527426) Lefranc M.P. … Rabbitts T.H. (Trends Biochem. Sci. 1989) 3 64

Products for TRGC2 Gene

Sources for TRGC2 Gene

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