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TRGC2 Gene

protein-coding   GIFtS: 27
GCID: GC07M038246

T Cell Receptor Gamma Constant 2


(Previous symbol: TCRGC2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
T Cell Receptor Gamma Constant 21 2     T-Cell Receptor1
TCRGC21 2 3     TRGC2(2X)2
Constant Region C21     TRGC2(3X)2
gamma1     T-Cell Receptor Gamma Chain C Region PT-Gamma-1/23

External Ids:    HGNC: 122761   Entrez Gene: 69672   Ensembl: ENSG000002271917   OMIM: 6154505   UniProtKB: P039863   

Export aliases for TRGC2 gene to outside databases

Previous GC identifers: GC07U990099 GC07M037986 GC07M038023 GC07M038024 GC07M038052 GC07M038163


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRGC2 Gene:
TRGC2 (T cell receptor gamma constant 2) is a protein-coding gene. GO annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is TRGC1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for TRGC2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TRGC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRGC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p14

TRGC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRGC2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M038246:  view genomic region     (about GC identifiers)

Start:
38,279,181 bp from pter      End:
38,289,173 bp from pter
Size:
9,993 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 38,317,305-38,326,857     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRGC2_HUMAN, P03986 (See protein sequence)
Recommended Name: T-cell receptor gamma-2 chain C region  
Size: 189 amino acids; 21554 Da
1 PDB 3D structure from and Proteopedia for TRGC2:
1HXM (3D)    

Explore the universe of human proteins at neXtProt for TRGC2: NX_P03986

Explore proteomics data for TRGC2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn66, Asn136, Asn142, Asn151

  • See TRGC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000413437  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRG: T cell receptors / TRG locus

    3 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set

    Graphical View of Domain Structure for InterPro Entry P03986

    ProtoNet protein and cluster: P03986

    1 Blocks protein domain: IPB003597 Immunoglobulin C-type

    UniProtKB/Swiss-Prot: TRGC2_HUMAN, P03986
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


    Find genes that share domains with TRGC2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity NAS3458221
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TRGC2           About GenesLikeMe


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRGC2_HUMAN, P03986: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane NAS3458221

    Find genes that share ontologies with TRGC2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRGC2
    Interactions:

        Search GeneGlobe Interaction Network for TRGC2

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS3458221
    GO:0007165signal transduction NAS3458221

    Find genes that share ontologies with TRGC2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TRGC2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000436911(uc003tfu.3 uc022aby.1 uc003tfv.3)
    miRNA
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    Selected AceView cDNA sequences (see all 359):

    BX281781 NM_001003799 BM478583 R33649 NM_001003806 CR605178 AW575113 BQ002856 
    BC062761 AV714756 BE326754 BM544213 BC072396 AI768834 BV205008 AV714189 
    BQ934484 AI961098 CA449324 AL559196 BV205007 BF674593 BC072387 BF109398 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRGC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TRGC2 Expression
    About this image

    TRGC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRGC2 Protein Expression
        Custom PCR Arrays for TRGC2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRGC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TRGC2 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tcrg-C25 T cell receptor gamma constant 2   --   13 (6.89 cM) 19305060 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    13(a)
    1 → many
    2(49671235-49698316)


    ENSEMBL Gene Tree for TRGC2 (if available)
    TreeFam Gene Tree for TRGC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRGC2 gene
    TRGC12  
    2 SIMAP similar genes for TRGC2 using alignment to 1 protein entry:     TRGC2_HUMAN:
    TRGC1    TARP

    Find genes that share paralogs with TRGC2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TRGC2
    DNA2.0 Custom Variant and Variant Library Synthesis for TRGC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615450    OMIM disorders: --


    Find genes that share disorders with TRGC2           About GenesLikeMe


    Export disorders for TRGC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRGC2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TRGC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequence analysis of complementary DNA encoding an aberrantly rearranged human T-cell gamma chain. (PubMed id 3458221)1, 2, 3 Dialynas D.P.... Strominger J.L. (Proc. Natl. Acad. Sci. U.S.A. 1986)
    2. Structure of a human gammadelta T-cell antigen receptor. (PubMed id 11459064)1, 2 Allison T.J....Garboczi D.N. (Nature 2001)
    3. Genetic polymorphism and exon changes of the constant regions of the human T-cell rearranging gene gamma. (PubMed id 2879283)1, 2 Lefranc M.P.... Rabbitts T.H. (Proc. Natl. Acad. Sci. U.S.A. 1986)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. The human T-cell receptor gamma (TRG) genes. (PubMed id 2527426)1 Lefranc M.P. and Rabbitts T.H. (Trends Biochem. Sci. 1989)
    6. Exon duplication and triplication in the human T-cell receptor gamma constant region genes and RFLP in French, Lebanese, Tunisian, and black African populations. (PubMed id 2564370)1 Buresi C....Lefranc M.P. (Immunogenetics 1989)
    7. Molecular diversity of the human T-gamma constant region genes. (PubMed id 3112943)1 Pelicci P.G....Littman D.R. (Science 1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6967 HGNC: 12276 AceView: TRG_ Ensembl:ENSG00000227191 euGenes: HUgn6967
    ECgene: TRGC2 H-InvDB: TRGC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRGC2 Pharmacogenomics, SNPs, Pathways
    IMGT entry for TRGC2 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
    IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+TRGC2&species=Homo+sapiens

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRGC2 gene:
    Search GeneIP for patents involving TRGC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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