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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRGC2 Gene

protein-coding   GIFtS: 25
GCID: GC07M038246

T Cell Receptor Gamma Constant 2


(Previous symbol: TCRGC2)
  Search for TRGC2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
T Cell Receptor Gamma Constant 21 2     T-Cell Receptor1
TCRGC21 2 3     TRGC2(2X)2
Constant Region C21     TRGC2(3X)2
gamma1     T-Cell Receptor Gamma Chain C Region PT-Gamma-1/23

External Ids:    HGNC: 122761   Entrez Gene: 69672   Ensembl: ENSG000002271917   OMIM: 6154505   UniProtKB: P039863   

Export aliases for TRGC2 gene to outside databases

Previous GC identifers: GC07U990099 GC07M037986 GC07M038023 GC07M038024 GC07M038052 GC07M038163


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TRGC2 Gene: 
TRGC2 (T cell receptor gamma constant 2) is a protein-coding gene. GO annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is TRGC1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TRGC2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRGC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p14

TRGC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRGC2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M038246:  view genomic region     (about GC identifiers)

Start:
38,279,181 bp from pter      End:
38,289,173 bp from pter
Size:
9,993 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 38,317,305-38,326,857     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRGC2_HUMAN, P03986 (See protein sequence)
Recommended Name: T-cell receptor gamma-2 chain C region  
Size: 189 amino acids; 21554 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
1 PDB 3D structure from and Proteopedia for TRGC2:
1HXM (3D)    

Explore the universe of human proteins at neXtProt for TRGC2: NX_P03986

Explore proteomics data for TRGC2 at MOPED 

TRGC2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TRGC2 Protein Expression

ENSEMBL proteins: 
 ENSP00000413437  

Human Recombinant Protein Products for TRGC2: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005887integral to plasma membrane NAS3458221

TRGC2 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
TRG: T cell receptors / TRG locus

3 InterPro protein domains:
 IPR007110 Ig-like_dom
 IPR013783 Ig-like_fold
 IPR003597 Ig_C1-set

Graphical View of Domain Structure for InterPro Entry P03986

ProtoNet protein and cluster: P03986

1 Blocks protein domain: IPB003597 Immunoglobulin C-type

UniProtKB/Swiss-Prot: TRGC2_HUMAN, P03986
Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


TRGC2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004888transmembrane signaling receptor activity NAS3458221
GO:0005515protein binding ----
     
TRGC2 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRGC2

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response NAS3458221

TRGC2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for TRGC2

Search CenterWatch for drugs/clinical trials and news about TRGC2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000436911(uc003tfu.3 uc022aby.1 uc003tfv.3)
miRNA
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24/359 AceView cDNA sequences (see all 359):

BQ002856 R33649 CR605178 BM478583 BX281781 AW575113 NM_001003806 NM_001003799 
BF679325 CA449324 BC062761 BV205029 AV714756 AI637495 BV205017 AI758378 
BE974171 AI961098 AJ583014 AV714189 AV716204 AI718234 AI972955 AK056843 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRGC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TRGC2 Expression
About this image


See TRGC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRGC2
    SABiosciences Custom PCR Arrays for TRGC2
Primer
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TRGC2 gene from 2/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tcrg-C25 T cell receptor gamma constant 2   --   13 (6.89 cM) 19305060 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
13(a)
1 → many
2(49671235-49698316)


ENSEMBL Gene Tree for TRGC2 (if available)
TreeFam Gene Tree for TRGC2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TRGC2 gene
TRGC12  
2 SIMAP similar genes for TRGC2 using alignment to 1 protein entry:     TRGC2_HUMAN:
TRGC1    TARP

TRGC2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing TRGC2
DNA2.0 Custom Variant and Variant Library Synthesis for TRGC2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRGC2 for disorders           About MalaCards
OMIM gene information: 615450    OMIM disorders: --


TRGC2 for disorders           About GeneDecksing


Export disorders for TRGC2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TRGC2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRGC2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and sequence analysis of complementary DNA encoding an aberrantly rearranged human T-cell gamma chain. (PubMed id 3458221)1, 2, 3 Dialynas D.P.... Strominger J.L. (1986)
  2. Structure of a human gammadelta T-cell antigen receptor. (PubMed id 11459064)1, 2 Allison T.J....Garboczi D.N. (2001)
  3. Genetic polymorphism and exon changes of the constant regions of the human T-cell rearranging gene gamma. (PubMed id 2879283)1, 2 Lefranc M.P.... Rabbitts T.H. (1986)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  5. The human T-cell receptor gamma (TRG) genes. (PubMed id 2527426)1 Lefranc M.P. and Rabbitts T.H. (1989)
  6. Exon duplication and triplication in the human T-cell receptor gamma constant region genes and RFLP in French, Lebanese, Tunisian, and black African populations. (PubMed id 2564370)1 Buresi C....Lefranc M.P. (1989)
  7. Molecular diversity of the human T-gamma constant region genes. (PubMed id 3112943)1 Pelicci P.G....Littman D.R. (1987)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 6967 HGNC: 12276 AceView: TRG_ Ensembl:ENSG00000227191 euGenes: HUgn6967
ECgene: TRGC2 H-InvDB: TRGC2

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TRGC2 Pharmacogenomics, SNPs, Pathways
IMGT entry for TRGC2 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+TRGC2&species=Homo+sapiens

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TRGC2 gene:
Search GeneIP for patents involving TRGC2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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